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https://www.readbyqxmd.com/read/28724375/bilateral-idiopathic-retinal-vasculitis-following-coxsackievirus-a4-infection-a-case-report
#1
Izumi Mine, Manzo Taguchi, Yutaka Sakurai, Masaru Takeuchi
BACKGROUND: Coxsackieviruses are members of a group of viruses called the enteroviruses, which may cause respiratory and gastrointestinal symptoms, erythema, meningoencephalitis, myocarditis, pericarditis, and myositis. Unilateral acute idiopathic maculopathy caused by coxsackievirus A16 has been associated with hand, foot, and mouth disease, but only a few reports describe retinitis associated with coxsackievirus serotype B3 or B4. We report a case of bilateral multifocal obstructive retinal vasculitis that developed after coxsackievirus A4 infection...
July 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28719027/marker-of-coxsackievirus-b4-infection-in-saliva-of-patients-with-type-1-diabetes
#2
F Badia-Boungou, F Sane, E K Alidjinou, M Ternois, P A Opoko, J Haddad, C Stukens, C Lefevre, I Gueorguieva, M Hamze, M Ismail, J Weill, H G Monabéka, E Bouenizabila, D Moukassa, A A Abena, D Hober
BACKGROUND: Coxsackieviruses B (CV-B) are enteroviruses that have been reported to play a role in the pathogenesis of type 1 diabetes. Enteroviral RNA was detected in the gut mucosa of patients. The mucosal immunity is an interconnected network, therefore the response to enteroviruses possibly present in the gastrointestinal mucosa can be reflected by specific antibodies in the saliva. In the present study the anti-CV-B neutralizing activity of saliva samples from patients with type 1 diabetes was investigated...
July 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28711987/getting-genetic-access-to-natural-adenovirus-genomes-to-explore-vector-diversity
#3
REVIEW
Wenli Zhang, Anja Ehrhardt
Recombinant vectors based on the human adenovirus type 5 (HAdV5) have been developed and extensively used in preclinical and clinical studies for over 30 years. However, certain restrictions of HAdV5-based vectors have limited their clinical applications because they are rather inefficient in specifically transducing cells of therapeutic interest that lack the coxsackievirus and adenovirus receptor (CAR). Moreover, enhanced vector-associated toxicity and widespread preexisting immunity have been shown to significantly hamper the effectiveness of HAdV-5-mediated gene transfer...
July 15, 2017: Virus Genes
https://www.readbyqxmd.com/read/28710474/persistent-circulation-of-coxsackievirus-a6-of-genotype-d3-in-mainland-of-china-between-2008-and-2015
#4
Yang Song, Yong Zhang, Tianjiao Ji, Xinrui Gu, Qian Yang, Shuangli Zhu, Wen Xu, Yi Xu, Yong Shi, Xueyong Huang, Qi Li, Hong Deng, Xianjun Wang, Dongmei Yan, Wei Yu, Shuang Wang, Deshan Yu, Wenbo Xu
A total of 807 entire VP1 sequences of Coxsackievirus A6 (CV-A6) from mainland of China from 1992 to 2015, including 520 in this study and 287 from the GenBank database, were analysed to provide a basic framework of molecular epidemiological characteristics of CV-A6 in China. Sixty-five VP1 sequences including 46 representative CV-A6 isolates from 807 Chinese strains and 19 international strains from GenBank were used for describing the genotypes and sub-genotypes. The results revealed that CV-A6 strains can be categorised into 4 genotypes designated as A, B, C, and D according to previous data and can be further subdivided into B1-B2, C1-C2, and D1-D3 sub-genotypes...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692654/estimating-the-basic-reproduction-rate-of-hfmd-using-the-time-series-sir-model-in-guangdong-china
#5
Zhicheng Du, Wangjian Zhang, Dingmei Zhang, Shicheng Yu, Yuantao Hao
Hand, foot, and mouth disease (HFMD) has caused a substantial burden of disease in China, especially in Guangdong Province. Based on notifiable cases, we use the time series Susceptible-Infected-Recovered model to estimate the basic reproduction rate (R0) and the herd immunity threshold, understanding the transmission and persistence of HFMD more completely for efficient intervention in this province. The standardized difference between the reported and fitted time series of HFMD was 0.009 (<0.2). The median basic reproduction rate of total, enterovirus 71, and coxsackievirus 16 cases in Guangdong were 4...
2017: PloS One
https://www.readbyqxmd.com/read/28691129/preponderance-of-enterovirus-c-in-rd-l20b-cell-culture-negative-stool-samples-from-children-diagnosed-with-acute-flaccid-paralysis-in-nigeria
#6
J A Adeniji, A O Oragwa, U E George, U I Ibok, T O C Faleye, M O Adewumi
Recently, a reverse transcriptase semi-nested polymerase chain reaction (RT-snPCR) assay was recommended by the WHO for direct detection of enteroviruses in clinical specimens. In this study, we use this assay and a modification thereof to screen acute flaccid paralysis (AFP) samples that had previously tested negative for enteroviruses by the RD-L20B algorithm. Thirty paired stool suspensions collected in 2015 as part of the national AFP surveillance program in different states of Nigeria were analyzed in this study...
July 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28681725/a-mild-phenotype-of-hand-foot-and-mouth-disease-caused-by-coxsackievirus-a6
#7
Mai Hattori, Akira Shimizu, Hiroyuki Tsukagoshi, Nobuhiro Saruki, Kyoichi Kaira, Tsukasa Ohkawa, Osamu Ishikawa
No abstract text is available yet for this article.
July 5, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28670500/peculiar-clinical-presentation-of-coxsackievirus-b4-infection-neonatal-restrictive-cardiomyopathy
#8
Pauline Le Van Quyen, Philippe Desprez, Angelo Livolsi, Véronique Lindner, Samira Fafi-Kremer, Pauline Helms, Maria Cristina Antal
Introduction  Restrictive cardiomyopathy in fetuses and neonates is extremely rare and has a poor outcome. Its etiology in neonates is elusive: metabolic diseases (e.g., Gaucher, Hurler syndrome), neuromuscular disorders (e.g., muscular dystrophies, myofibrillar myopathies), or rare presentation of genetic syndromes (e.g., Coffin-Lowry syndrome) account for a minority of the cases, the majority remaining idiopathic. Case Study  We report the case of a 17-day-old male infant presenting cardiogenic shock following a restrictive dysfunction of the left ventricle...
April 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28663145/type-1-diabetes-and-type-1-interferonopathies-localization-of-a-type-1-common-thread-of-virus-infection-in-the-pancreas
#9
REVIEW
Virginie S E Jean-Baptiste, Chang-Qing Xia, Michael J Clare-Salzler, Marc S Horwitz
Type 1 diabetes (T1D) has been associated with both genetic and environmental factors. Increasing incidence of T1D worldwide is prompting researchers to adopt different approaches to explain the biology of T1D, beyond the presence and activity of autoreactive lymphocytes. In this review, we propose inflammatory pathways as triggers for T1D. Within the scope of those inflammatory pathways and in understanding the pathogenesis of disease, we suggest that viruses, in particular Coxsackieviruses, act by causing a type 1 interferonopathy within the pancreas and the microenvironment of the islet...
June 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28662914/development-of-single-step-multiplex-real-time-rt-pcr-assays-for-rapid-diagnosis-of-enterovirus-71-coxsackievirus-a6-and-a16-in-patients-with-hand-foot-and-mouth-disease
#10
Jiratchaya Puenpa, Kamol Suwannakarn, Jira Chansaenroj, Sompong Vongpunsawad, Yong Poovorawan
Real-time reverse-transcription polymerase chain reaction (rRT-PCR) to detect enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) has facilitated the rapid and accurate identification of the two most common etiological agents underlying hand, foot, and mouth disease (HFMD). However, the worldwide emergence of CV-A6 infection in HFMD necessitates development of an improved multiplex rRT-PCR method. To rapidly determine the etiology of HFMD, two rRT-PCR assays using TaqMan probes were developed to differentiate among three selected common enteroviruses (EV-A71, CV-A16 and CV-A6) and to enable broad detection of enteroviruses (pan-enterovirus assay)...
June 27, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28659474/phylogeography-of-coxsackievirus-a16-reveals-global-transmission-pathways-and-recent-emergence-and-spread-of-a-recombinant-genogroup
#11
Chervin Hassel, Audrey Mirand, Agnes Farkas, Sabine Diedrich, Hartwig P Huemer, Hélène Peigue-Lafeuille, Christine Archimbaud, Cécile Henquell, Jean-Luc Bailly
Coxsackievirus A16 (CV-A16; Picornaviridae) is an enterovirus (EV) type associated with hand-foot-and-mouth disease (HFMD) in children. To investigate the spatial spread of CV-A16, we used viral sequence data sampled during a prospective sentinel surveillance of HFMD in France (2010--2014) and phylogenetic reconstruction. A dataset of 168 VP1 sequences was assembled with 416 publicly available sequences of various geographic origins. The CV-A16 sequences reported were assigned to two clades, genogroup B and a previously uncharacterized clade D...
June 28, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28656176/a-three-dimensional-cell-culture-system-to-model-rna-virus-infections-at-the-blood-brain-barrier
#12
John C Bramley, Coyne G Drummond, Nicholas J Lennemann, Charles A Good, Kwang Sik Kim, Carolyn B Coyne
The blood-brain barrier (BBB) comprises the foremost protective barrier in the brain and is composed in part of a layer of microvascular endothelial cells that line the capillaries surrounding the brain. Here, we describe a human three-dimensional (3-D) cell-based model of the BBB microvascular endothelium that recapitulates properties of these cells in vivo, including physiologically relevant transcriptional profiles, the capacity to induce potent antimicrobial innate immune signaling, and the ability to resist infection by diverse RNA viruses, including members of the enterovirus (coxsackievirus B, echovirus 11, enterovirus 71, poliovirus) and flavivirus (dengue virus, Zika virus [ZIKV]) families...
May 2017: MSphere
https://www.readbyqxmd.com/read/28644868/electrophysiological-alterations-in-a-murine-model-of-chronic-coxsackievirus-b3-myocarditis
#13
Sven Kaese, Robert Larbig, Matthias Rohrbeck, Gerrit Frommeyer, Dirk Dechering, Jan Olligs, Sabine Schönhofer-Merl, Rainer Wessely, Karin Klingel, Guiscard Seebohm, Lars Eckardt
INTRODUCTION: Coxsackievirus B3 (CVB3) is known to induce acute and chronic myocarditis. Most infections are clinically unapparent but some patients suffer from ventricular arrhythmias (VA) and sudden cardiac death (SCD). Studies showed that acute CVB3 infection may cause impaired function of cardiac ion channels, creating a proarrhythmic substrate. However, it is unknown whether low level CVB3+ expression in myocytes may cause altered cardiac electrophysiology leading to VA. METHODS: Cellular electrophysiology was used to analyze cellular action potentials (APs) and occurrence of afterdepolarizations from isolated cardiomyocytes of wildtype (WT) and transgenic CVB3ΔVP0 (CVB3+) mice...
2017: PloS One
https://www.readbyqxmd.com/read/28642849/aim2-co-immunization-with-vp1-is-associated-with-increased-memory-cd8-t-cells-and-mounts-long-lasting-protection-against-coxsackievirus-b3-challenge
#14
Liang Yin, Dafei Chai, Yan Yue, Chunsheng Dong, Sidong Xiong
The recurrent Coxsackievirus B3 (CVB3) infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection against CVB3 infection. In this study, absent in melanoma 2 (AIM2) was used as an adjuvant to enhance the induction of memory CD8 T cells elicited by VP1 (viral capsid protein 1) vaccine. Mice were intramuscularly injected with 50 μg AIM2 plasmid and equal amount of VP1 plasmid (pAIM2/pVP1) vaccine 4 times at 2 week-intervals...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28640379/comparative-and-correlative-assessments-of-cytokine-complement-and-antibody-patterns-in-pediatric-type-1-diabetes
#15
M Abdel-Latif, A A Abdel-Moneim, M H El-Hefnawy, R G Khalil
One of the most widespread and effective environmental factors is the infection with enteroviruses (EVs) which accelerate β - cell destruction in type 1 diabetes (T1D). This study represented a comparison between diabetic EV(+) and EV- children as well as correlation analysis between autoantibodies, T1D markers, cytokines, complement activation products and anti- coxsackievirus (CV) IgG. EV RNA was detected in Egyptian children with T1D (26.2%) and healthy controls (0%). Detection of anti - CV IgG in T1D - EV(+) resulted in 64% positivity...
June 22, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28633417/polypyrimidine-tract-binding-protein-ptb-and-ptb-associated-splicing-factor-in-cvb3-infection-an-itaf-for-an-itaf
#16
Pratik Dave, Biju George, Divya Khandige Sharma, Saumitra Das
The 5΄ UTR of Coxsackievirus B3 (CVB3) contains internal ribosome entry site (IRES), which allows cap-independent translation of the viral RNA and a 5΄-terminal cloverleaf structure that regulates viral replication, translation and stability. Here, we demonstrate that host protein PSF (PTB associated splicing factor) interacts with the cloverleaf RNA as well as the IRES element. PSF was found to be an important IRES trans acting factor (ITAF) for efficient translation of CVB3 RNA. Interestingly, cytoplasmic abundance of PSF protein increased during CVB3 infection and this is regulated by phosphorylation status at two different amino acid positions...
June 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28631594/human-picornaviruses-associated-with-neurological-diseases-and-their-neutralization-by-antibodies
#17
REVIEW
Maria Anastasina, Aušra Domanska, Kaia Palm, Sarah Butcher
Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s...
June 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28630462/identification-and-molecular-characterization-of-non-polio-enteroviruses-from-children-with-acute-flaccid-paralysis-in-west-africa-2013-2014
#18
Maria D Fernandez-Garcia, Ousmane Kebe, Aichatou D Fall, Kader Ndiaye
Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625478/a-neonatal-mouse-model-of-coxsackievirus-a10-infection-for-anti-viral-evaluation
#19
Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Longfa Xu, Yangtao Wu, Wei Wang, Chunye Chen, Junkai Wan, Xiangzhong Ye, Zhenglun Liang, Qunying Mao, Tong Cheng, Ningshao Xia
Epidemiological data indicate that coxsackievirus A10 (CVA10) has become one of the main causative agents of hand, foot and mouth disease (HFMD) and in recent years has often been found to co-circulate with other enteroviruses, which poses a challenge for the prevention and control of HFMD. Although most CVA10-associated HFMD cases present mild symptoms, severe manifestations and even death can also occur. However, the study of the pathogenesis and the development of drugs and vaccines for CVA10 infection are still far from complete...
June 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28610823/pre-vaccination-evolution-of-antibodies-among-infants-0-3-and-6months-of-age-a-longitudinal-analysis-of-measles-enterovirus-71-and-coxsackievirus-16
#20
Chuanxi Fu, Jichuan Shen, Long Lu, Yajing Li, Yimin Cao, Ming Wang, Sen Pei, Zhicong Yang, Qing Guo, Jeffrey Shaman
BACKGROUND: Due to waning levels of maternal antibodies (measles; enterovirus 71, EV71; and coxsackievirus A16, CoxA16), some infants may lose protection against infection prior to vaccination. Using a longitudinal design, we examine how maternal antibody levels evolve over time in infants prior to vaccination. METHODS: In 2013-2014, we collected sera at ages 0, 3 and 6months from infants. We assayed for levels of measles IgG antibody (717, 233 and 75 sample sera tested at months 0, 3 and 6, respectively), and neutralizing antibodies for EV71 and CoxA16 (225, 217, and 72)...
June 10, 2017: Vaccine
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