keyword
MENU ▼
Read by QxMD icon Read
search

Cortical representation of pain

keyword
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#1
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28390217/painful-engrams-oscillatory-correlates-of-working-memory-for-phasic-nociceptive-laser-stimuli
#2
Elia Valentini, Valentina Nicolardi, Salvatore Maria Aglioti
Research suggests that working memory (WM) is impaired in chronic pain. Yet, information on how potentially noxious stimuli are maintained in memory is limited in patients as well as in healthy people. We recorded electroencephalography (EEG) in healthy volunteers during a modified delayed match-to-sample task where maintenance in memory of relevant attributes of nociceptive laser stimuli was essential for subsequent cued-discrimination. Participants performed in high and low load conditions (i.e. three vs...
April 5, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28340134/primary-motor-cortex-organization-is-altered-in-persistent-patellofemoral-pain
#3
Maxine Te, Abrahão F Baptista, Lucy S Chipchase, Siobhan M Schabrun
Objective.:  Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls. Design.:  Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28284238/applying-current-concepts-in-pain-related-brain-science-to-dance-rehabilitation
#4
Sarah B Wallwork, Valeria Bellan, G Lorimer Moseley
Dance involves exemplary sensory-motor control, which is subserved by sophisticated neural processing at the spinal cord and brain level. Such neural processing is altered in the presence of nociception and pain, and the adaptations within the central nervous system that are known to occur with persistent nociception or pain have clear implications for movement and, indeed, risk of further injury. Recent rapid advances in our understanding of the brain's representation of the body and the role of cortical representations, or "neurotags," in bodily protection and regulation have given rise to new strategies that are gaining traction in sports medicine...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28237612/effects-of-chondroitin-sulfate-on-brain-response-to-painful-stimulation-in-knee-osteoarthritis-patients-a-randomized-double-blind-placebo-controlled-functional-magnetic-resonance-imaging-study
#5
Jordi Monfort, Jesús Pujol, Oren Contreras-Rodríguez, Jone Llorente-Onaindia, Marina López-Solà, Laura Blanco-Hinojo, Josep Vergés, Marta Herrero, Laura Sánchez, Hector Ortiz, Francisco Montañés, Joan Deus, Pere Benito
INTRODUCTION: Knee osteoarthritis is causing pain and functional disability. One of the inherent problems with efficacy assessment of pain medication was the lack of objective pain measurements, but functional magnetic resonance imaging (fMRI) has emerged as a useful means to objectify brain response to painful stimulation. We have investigated the effect of chondroitin sulfate (CS) on brain response to knee painful stimulation in patients with knee osteoarthritis using fMRI. METHODS: Twenty-two patients received CS (800mg/day) and 27 patients placebo, and were assessed at baseline and after 4 months of treatment...
February 22, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27452295/temporal-summation-of-the-nociceptive-withdrawal-reflex-involves-deactivation-of-posterior-cingulate-cortex
#6
A Perrotta, P Chiacchiaretta, M G Anastasio, L Pavone, G Grillea, M Bartolo, E Siravo, C Colonnese, R De Icco, M Serrao, G Sandrini, F Pierelli, A Ferretti
BACKGROUND: Temporal summation of pain sensation is pivotal both in physiological and pathological nociception. In humans, it develops in parallel with temporal summation of the nociceptive withdrawal reflex (NWR) of the lower limb, an objective representation of the temporal processing of nociceptive signals into the spinal cord. METHODS: To study the contribution of cortical and subcortical structures in temporal summation of pain reflex responses, we compared the fMRI signal changes related to the temporal summation threshold (TST) of the NWR with that related to the single NWR response...
July 25, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27244113/reorganization-in-secondary-somatosensory-cortex-in-chronic-low-back-pain-patients
#7
Sabina Hotz-Boendermaker, Valentine L Marcar, Michael L Meier, Bart Boendermaker, Barry K Humphreys
STUDY DESIGN: A cross-sectional comparative study between chronic low back pain (CLBP) patients and healthy control subjects. OBJECTIVE: The aim of this study was to investigate reorganization in the sensory cortex by comparing cortical activity due to mechanosensory stimulation of the lumbar spine in CLBP patients versus a control group by using functional magnetic resonance imaging (fMRI). SUMMARY OF BACKGROUND DATA: LBP is now the number 1 condition across the world in terms of years living with a disability...
June 2016: Spine
https://www.readbyqxmd.com/read/27084886/functional-interictal-changes-of-pain-processing-in-migraine-with-ictal-cutaneous-allodynia
#8
Antonio Russo, Fabrizio Esposito, Francesca Conte, Michele Fratello, Giuseppina Caiazzo, Laura Marcuccio, Alfonso Giordano, Gioacchino Tedeschi, Alessandro Tessitore
Objective A prospective clinical imaging study has been conducted to investigate pain processing functional pathways during trigeminal heat stimulation (THS) in patients with migraine without aura experiencing ictal cutaneous allodynia (CA) (MwoA CA+). Methods Using whole-brain BOLD-fMRI, functional response to THS at three different intensities (41°, 51° and 53℃) was investigated interictally in 20 adult MwoA CA+ patients compared with 20 MwoA patients without ictal CA (MwoA CA-) and 20 healthy controls (HCs)...
April 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/26980192/the-hand-motor-hotspot-is-not-always-located-in-the-hand-knob-a-neuronavigated-transcranial-magnetic-stimulation-study
#9
Rechdi Ahdab, Samar S Ayache, Pierre Brugières, Wassim H Farhat, Jean-Pascal Lefaucheur
The hand motor hot spot (hMHS) is one of the most salient parameters in transcranial magnetic stimulation (TMS) practice, notably used for targeting. It is commonly accepted that the hMHS corresponds to the hand representation within the primary motor cortex (M1). Anatomical and imaging studies locate this representation in a region of the central sulcus called the "hand knob". The aim of this study was to determine if the hMHS location corresponds to its expected location at the hand knob. Twelve healthy volunteers and eleven patients with chronic neuropathic pain of various origins, but not related to a brain lesion, were enrolled...
July 2016: Brain Topography
https://www.readbyqxmd.com/read/26871462/altered-function-of-intracortical-networks-in-chronic-lateral-epicondylalgia
#10
E Burns, L S Chipchase, S M Schabrun
BACKGROUND: Lateral epicondylalgia (LE) is a musculotendinous condition characterized by persistent pain, sensorimotor dysfunction and motor cortex reorganization. Although there is evidence linking cortical reorganization with clinical symptoms in LE, the mechanisms underpinning these changes are unknown. Here we investigated activity in motor cortical (M1) intracortical inhibitory and facilitatory networks in individuals with chronic LE and healthy controls. METHODS: Surface electromyography was recorded bilaterally from the extensor carpi radialis brevis (ECRB) muscle of 14 LE (4 men, 41...
August 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/26869915/pain-related-cortical-oscillations-methodological-advances-and-potential-applications
#11
REVIEW
Weiwei Peng, Dandan Tang
Alongside the time-locked event-related potentials (ERPs), nociceptive somatosensory inputs can induce modulations of ongoing oscillations, appeared as event-related synchronization or desynchronization (ERS/ERD) in different frequency bands. These ERD/ERS activities are suggested to reflect various aspects of pain perception, including the representation, encoding, assessment, and integration of the nociceptive sensory inputs, as well as behavioral responses to pain, even the precise details of their roles remain unclear...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/26854561/primary-motor-cortex-changes-after-amputation-correlate-with-phantom-limb-pain-and-the-ability-to-move-the-phantom-limb
#12
Estelle Raffin, Nathalie Richard, Pascal Giraux, Karen T Reilly
A substantial body of evidence documents massive reorganization of primary sensory and motor cortices following hand amputation, the extent of which is correlated with phantom limb pain. Many therapies for phantom limb pain are based upon the idea that plastic changes after amputation are maladaptive and attempt to normalize representations of cortical areas adjacent to the hand area. Recent data suggest, however, that higher levels of phantom pain are associated with stronger local activity and more structural integrity in the missing hand area rather than with reorganization of neighbouring body parts...
April 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/26846218/high-hypnotizability-impairs-the-cerebellar-control-of-pain
#13
Tommaso Bocci, Davide Barloscio, Laura Parenti, Ferdinando Sartucci, Giancarlo Carli, Enrica L Santarcangelo
In the general population, transcranial anodal direct current stimulation of the cerebellum (ctDCS) reduces pain intensity and the amplitude of nociceptive laser evoked potentials (LEPs), whereas cathodal ctDCS elicits opposite effects. Since behavioral findings suggest that the cerebellar activity of highly hypnotizable individuals (highs) differs from the general population, we investigated whether hypnotizability-related differences occur in the modulation of pain by ctDCS. Sixteen healthy highs (according to the Stanford Hypnotic Susceptibility Scale, form A) and 16 participants not selected according to hypnotizability (controls) volunteered to undergo laser nociceptive stimulation of the dorsum of the left hand before and after anodal or cathodal ctDCS...
February 2017: Cerebellum
https://www.readbyqxmd.com/read/26800319/motor-imagery-in-spinal-cord-injured-people-is-modulated-by-somatotopic-coding-perspective-taking-and-post-lesional-chronic-pain
#14
Michele Scandola, Salvatore M Aglioti, Polona Pozeg, Renato Avesani, Valentina Moro
Motor imagery (MI) allows one to mentally represent an action without necessarily performing it. Importantly, however, MI is profoundly influenced by the ability to actually execute actions, as demonstrated by the impairment of this ability as a consequence of lesions in motor cortices, limb amputations, movement limiting chronic pain, and spinal cord injury. Understanding MI and its deficits in patients with motor limitations is fundamentally important as development of some brain-computer interfaces and daily life strategies for coping with motor disorders are based on this ability...
January 22, 2016: Journal of Neuropsychology
https://www.readbyqxmd.com/read/26682866/neural-representations-and-the-cortical-body-matrix-implications-for-sports-medicine-and-future-directions
#15
REVIEW
Sarah B Wallwork, Valeria Bellan, Mark J Catley, G Lorimer Moseley
Neural representations, or neurotags, refer to the idea that networks of brain cells, distributed across multiple brain areas, work in synergy to produce outputs. The brain can be considered then, a complex array of neurotags, each influencing and being influenced by each other. The output of some neurotags act on other systems, for example, movement, or on consciousness, for example, pain. This concept of neurotags has sparked a new body of research into pain and rehabilitation. We draw on this research and the concept of a cortical body matrix-a network of representations that subserves the regulation and protection of the body and the space around it-to suggest important implications for rehabilitation of sports injury and for sports performance...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26621512/organisation-and-function-of-the-primary-motor-cortex-in-chronic-pain-protocol-for-a-systematic-review-and-meta-analysis
#16
Wei-Ju Chang, Neil E O'Connell, Emma Burns, Lucy S Chipchase, Matthew B Liston, Siobhan M Schabrun
INTRODUCTION: Primary motor cortical (M1) adaptation in the form of altered organisation and function is hypothesised to underpin motor dysfunction observed in chronic pain. The aim of this review is to assess the evidence for altered M1 organisation and function in chronic pain. METHODS AND ANALYSIS: Systematic review and meta-analysis. We will search electronic databases with predetermined search terms to identify relevant studies and evaluate the studies for inclusion and risks of bias...
2015: BMJ Open
https://www.readbyqxmd.com/read/26588697/a-longitudinal-study-of-pain-personality-and-brain-plasticity-following-peripheral-nerve-injury
#17
Ruma Goswami, Dimitri J Anastakis, Joel Katz, Karen D Davis
We do not know precisely why pain develops and becomes chronic after peripheral nerve injury (PNI), but it is likely due to biological and psychological factors. Here, we tested the hypotheses that (1) high Pain Catastrophizing Scale (PCS) scores at the time of injury and repair are associated with pain and cold sensitivity after 1-year recovery and (2) insula gray matter changes reflect the course of injury and improvements over time. Ten patients with complete median and/or ulnar nerve transections and surgical repair were tested ∼3 weeks after surgical nerve repair (time 1) and ∼1 year later for 6 of the 10 patients (time 2)...
March 2016: Pain
https://www.readbyqxmd.com/read/26587289/the-plasticity-of-brain-gray-matter-and-white-matter-following-lower-limb-amputation
#18
Guangyao Jiang, Xuntao Yin, Chuanming Li, Lei Li, Lu Zhao, Alan C Evans, Tianzi Jiang, Jixiang Wu, Jian Wang
Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC)...
2015: Neural Plasticity
https://www.readbyqxmd.com/read/26376409/cortical-representation-of-afferent-bodily-signals-in-borderline-personality-disorder-neural-correlates-and-relationship-to-emotional-dysregulation
#19
Laura E Müller, André Schulz, Martin Andermann, Andrea Gäbel, Dorothee Maria Gescher, Angelika Spohn, Sabine C Herpertz, Katja Bertsch
IMPORTANCE: The ability to perceive and regulate one's own emotions has been tightly linked to the processing of afferent bodily signals (interoception). Thus, disturbed interoception might contribute to the core feature of emotional dysregulation in borderline personality disorder (BPD), as increased levels of depersonalization, body image disturbances, and reduced sensitivity to physical pain suggest poor body awareness in BPD. OBJECTIVE: To determine neural correlates of disturbed body awareness in BPD and its associations with emotional dysregulation and to explore improvements in body awareness with BPD symptom remission...
November 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/26198686/laterality-judgments-in-people-with-low-back-pain-a-cross-sectional-observational-and-test-retest-reliability-study
#20
COMPARATIVE STUDY
Martin Linder, Peter Michaelson, Ulrik Röijezon
BACKGROUND: Disruption of cortical representation, or body schema, has been indicated as a factor in the persistence and recurrence of low back pain (LBP). This has been observed through impaired laterality judgment ability and it has been suggested that this ability is affected in a spatial rather than anatomical manner. OBJECTIVES: We compared laterality judgment performance of foot and trunk movements between people with LBP with or without leg pain and healthy controls, and investigated associations between test performance and pain...
February 2016: Manual Therapy
keyword
keyword
30893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"