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Cortical representation of pain

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https://www.readbyqxmd.com/read/27452295/temporal-summation-of-the-nociceptive-withdrawal-reflex-involves-deactivation-of-posterior-cingulate-cortex
#1
A Perrotta, P Chiacchiaretta, M G Anastasio, L Pavone, G Grillea, M Bartolo, E Siravo, C Colonnese, R De Icco, M Serrao, G Sandrini, F Pierelli, A Ferretti
BACKGROUND: Temporal summation of pain sensation is pivotal both in physiological and pathological nociception. In humans, it develops in parallel with temporal summation of the nociceptive withdrawal reflex (NWR) of the lower limb, an objective representation of the temporal processing of nociceptive signals into the spinal cord. METHODS: To study the contribution of cortical and subcortical structures in temporal summation of pain reflex responses, we compared the fMRI signal changes related to the temporal summation threshold (TST) of the NWR with that related to the single NWR response...
July 25, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27244113/reorganization-in-secondary-somatosensory-cortex-in-chronic-low-back-pain-patients
#2
Sabina Hotz-Boendermaker, Valentine L Marcar, Michael L Meier, Bart Boendermaker, Barry K Humphreys
STUDY DESIGN: A cross-sectional comparative study between chronic low back pain (CLBP) patients and healthy control subjects. OBJECTIVE: The aim of this study was to investigate reorganization in the sensory cortex by comparing cortical activity due to mechanosensory stimulation of the lumbar spine in CLBP patients versus a control group by using functional magnetic resonance imaging (fMRI). SUMMARY OF BACKGROUND DATA: LBP is now the number 1 condition across the world in terms of years living with a disability...
June 2016: Spine
https://www.readbyqxmd.com/read/27084886/functional-interictal-changes-of-pain-processing-in-migraine-with-ictal-cutaneous-allodynia
#3
Antonio Russo, Fabrizio Esposito, Francesca Conte, Michele Fratello, Giuseppina Caiazzo, Laura Marcuccio, Alfonso Giordano, Gioacchino Tedeschi, Alessandro Tessitore
OBJECTIVE: A prospective clinical imaging study has been conducted to investigate pain processing functional pathways during trigeminal heat stimulation (THS) in patients with migraine without aura experiencing ictal cutaneous allodynia (CA) (MwoA CA+). METHODS: Using whole-brain BOLD-fMRI, functional response to THS at three different intensities (41°, 51° and 53℃) was investigated interictally in 20 adult MwoA CA+ patients compared with 20 MwoA patients without ictal CA (MwoA CA-) and 20 healthy controls (HCs)...
April 15, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/26980192/the-hand-motor-hotspot-is-not-always-located-in-the-hand-knob-a-neuronavigated-transcranial-magnetic-stimulation-study
#4
Rechdi Ahdab, Samar S Ayache, Pierre Brugières, Wassim H Farhat, Jean-Pascal Lefaucheur
The hand motor hot spot (hMHS) is one of the most salient parameters in transcranial magnetic stimulation (TMS) practice, notably used for targeting. It is commonly accepted that the hMHS corresponds to the hand representation within the primary motor cortex (M1). Anatomical and imaging studies locate this representation in a region of the central sulcus called the "hand knob". The aim of this study was to determine if the hMHS location corresponds to its expected location at the hand knob. Twelve healthy volunteers and eleven patients with chronic neuropathic pain of various origins, but not related to a brain lesion, were enrolled...
July 2016: Brain Topography
https://www.readbyqxmd.com/read/26871462/altered-function-of-intracortical-networks-in-chronic-lateral-epicondylalgia
#5
E Burns, L S Chipchase, S M Schabrun
BACKGROUND: Lateral epicondylalgia (LE) is a musculotendinous condition characterized by persistent pain, sensorimotor dysfunction and motor cortex reorganization. Although there is evidence linking cortical reorganization with clinical symptoms in LE, the mechanisms underpinning these changes are unknown. Here we investigated activity in motor cortical (M1) intracortical inhibitory and facilitatory networks in individuals with chronic LE and healthy controls. METHODS: Surface electromyography was recorded bilaterally from the extensor carpi radialis brevis (ECRB) muscle of 14 LE (4 men, 41...
August 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/26869915/pain-related-cortical-oscillations-methodological-advances-and-potential-applications
#6
REVIEW
Weiwei Peng, Dandan Tang
Alongside the time-locked event-related potentials (ERPs), nociceptive somatosensory inputs can induce modulations of ongoing oscillations, appeared as event-related synchronization or desynchronization (ERS/ERD) in different frequency bands. These ERD/ERS activities are suggested to reflect various aspects of pain perception, including the representation, encoding, assessment, and integration of the nociceptive sensory inputs, as well as behavioral responses to pain, even the precise details of their roles remain unclear...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/26854561/primary-motor-cortex-changes-after-amputation-correlate-with-phantom-limb-pain-and-the-ability-to-move-the-phantom-limb
#7
Estelle Raffin, Nathalie Richard, Pascal Giraux, Karen T Reilly
A substantial body of evidence documents massive reorganization of primary sensory and motor cortices following hand amputation, the extent of which is correlated with phantom limb pain. Many therapies for phantom limb pain are based upon the idea that plastic changes after amputation are maladaptive and attempt to normalize representations of cortical areas adjacent to the hand area. Recent data suggest, however, that higher levels of phantom pain are associated with stronger local activity and more structural integrity in the missing hand area rather than with reorganization of neighbouring body parts...
April 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/26846218/high-hypnotizability-impairs-the-cerebellar-control-of-pain
#8
Tommaso Bocci, Davide Barloscio, Laura Parenti, Ferdinando Sartucci, Giancarlo Carli, Enrica L Santarcangelo
In the general population, transcranial anodal direct current stimulation of the cerebellum (ctDCS) reduces pain intensity and the amplitude of nociceptive laser evoked potentials (LEPs), whereas cathodal ctDCS elicits opposite effects. Since behavioral findings suggest that the cerebellar activity of highly hypnotizable individuals (highs) differs from the general population, we investigated whether hypnotizability-related differences occur in the modulation of pain by ctDCS. Sixteen healthy highs (according to the Stanford Hypnotic Susceptibility Scale, form A) and 16 participants not selected according to hypnotizability (controls) volunteered to undergo laser nociceptive stimulation of the dorsum of the left hand before and after anodal or cathodal ctDCS...
February 5, 2016: Cerebellum
https://www.readbyqxmd.com/read/26800319/motor-imagery-in-spinal-cord-injured-people-is-modulated-by-somatotopic-coding-perspective-taking-and-post-lesional-chronic-pain
#9
Michele Scandola, Salvatore M Aglioti, Polona Pozeg, Renato Avesani, Valentina Moro
Motor imagery (MI) allows one to mentally represent an action without necessarily performing it. Importantly, however, MI is profoundly influenced by the ability to actually execute actions, as demonstrated by the impairment of this ability as a consequence of lesions in motor cortices, limb amputations, movement limiting chronic pain, and spinal cord injury. Understanding MI and its deficits in patients with motor limitations is fundamentally important as development of some brain-computer interfaces and daily life strategies for coping with motor disorders are based on this ability...
January 22, 2016: Journal of Neuropsychology
https://www.readbyqxmd.com/read/26682866/neural-representations-and-the-cortical-body-matrix-implications-for-sports-medicine-and-future-directions
#10
REVIEW
Sarah B Wallwork, Valeria Bellan, Mark J Catley, G Lorimer Moseley
Neural representations, or neurotags, refer to the idea that networks of brain cells, distributed across multiple brain areas, work in synergy to produce outputs. The brain can be considered then, a complex array of neurotags, each influencing and being influenced by each other. The output of some neurotags act on other systems, for example, movement, or on consciousness, for example, pain. This concept of neurotags has sparked a new body of research into pain and rehabilitation. We draw on this research and the concept of a cortical body matrix-a network of representations that subserves the regulation and protection of the body and the space around it-to suggest important implications for rehabilitation of sports injury and for sports performance...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26621512/organisation-and-function-of-the-primary-motor-cortex-in-chronic-pain-protocol-for-a-systematic-review-and-meta-analysis
#11
Wei-Ju Chang, Neil E O'Connell, Emma Burns, Lucy S Chipchase, Matthew B Liston, Siobhan M Schabrun
INTRODUCTION: Primary motor cortical (M1) adaptation in the form of altered organisation and function is hypothesised to underpin motor dysfunction observed in chronic pain. The aim of this review is to assess the evidence for altered M1 organisation and function in chronic pain. METHODS AND ANALYSIS: Systematic review and meta-analysis. We will search electronic databases with predetermined search terms to identify relevant studies and evaluate the studies for inclusion and risks of bias...
2015: BMJ Open
https://www.readbyqxmd.com/read/26588697/a-longitudinal-study-of-pain-personality-and-brain-plasticity-following-peripheral-nerve-injury
#12
Ruma Goswami, Dimitri J Anastakis, Joel Katz, Karen D Davis
We do not know precisely why pain develops and becomes chronic after peripheral nerve injury (PNI), but it is likely due to biological and psychological factors. Here, we tested the hypotheses that (1) high Pain Catastrophizing Scale (PCS) scores at the time of injury and repair are associated with pain and cold sensitivity after 1-year recovery and (2) insula gray matter changes reflect the course of injury and improvements over time. Ten patients with complete median and/or ulnar nerve transections and surgical repair were tested ∼3 weeks after surgical nerve repair (time 1) and ∼1 year later for 6 of the 10 patients (time 2)...
March 2016: Pain
https://www.readbyqxmd.com/read/26587289/the-plasticity-of-brain-gray-matter-and-white-matter-following-lower-limb-amputation
#13
Guangyao Jiang, Xuntao Yin, Chuanming Li, Lei Li, Lu Zhao, Alan C Evans, Tianzi Jiang, Jixiang Wu, Jian Wang
Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC)...
2015: Neural Plasticity
https://www.readbyqxmd.com/read/26376409/cortical-representation-of-afferent-bodily-signals-in-borderline-personality-disorder-neural-correlates-and-relationship-to-emotional-dysregulation
#14
Laura E Müller, André Schulz, Martin Andermann, Andrea Gäbel, Dorothee Maria Gescher, Angelika Spohn, Sabine C Herpertz, Katja Bertsch
IMPORTANCE: The ability to perceive and regulate one's own emotions has been tightly linked to the processing of afferent bodily signals (interoception). Thus, disturbed interoception might contribute to the core feature of emotional dysregulation in borderline personality disorder (BPD), as increased levels of depersonalization, body image disturbances, and reduced sensitivity to physical pain suggest poor body awareness in BPD. OBJECTIVE: To determine neural correlates of disturbed body awareness in BPD and its associations with emotional dysregulation and to explore improvements in body awareness with BPD symptom remission...
November 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/26198686/laterality-judgments-in-people-with-low-back-pain-a-cross-sectional-observational-and-test-retest-reliability-study
#15
Martin Linder, Peter Michaelson, Ulrik Röijezon
BACKGROUND: Disruption of cortical representation, or body schema, has been indicated as a factor in the persistence and recurrence of low back pain (LBP). This has been observed through impaired laterality judgment ability and it has been suggested that this ability is affected in a spatial rather than anatomical manner. OBJECTIVES: We compared laterality judgment performance of foot and trunk movements between people with LBP with or without leg pain and healthy controls, and investigated associations between test performance and pain...
February 2016: Manual Therapy
https://www.readbyqxmd.com/read/26188186/mortality-salience-modulates-cortical-responses-to-painful-somatosensory-stimulation-evidence-from-slow-wave-and-delta-band-activity
#16
Elia Valentini, Katharina Koch, Valentina Nicolardi, Salvatore Maria Aglioti
Social psychology studies show that awareness of one's eventual death profoundly influences human cognition and behaviour by inducing defensive reactions against end-of-life-related anxiety. Much less is known about the impact of reminders of mortality on brain activity. Here we tested whether reminders of mortality can induce a modulation of the slow electroencephalographic activity triggered by somatosensory nociceptive or auditory threatening stimulation and if this modulation is related to mood and anxiety as well as personality traits...
October 15, 2015: NeuroImage
https://www.readbyqxmd.com/read/26115372/effects-of-transcranial-direct-current-stimulation-tdcs-on-pain-distress-tolerance-a-preliminary-study
#17
Timothy Y Mariano, Mascha van't Wout, Benjamin L Jacobson, Sarah L Garnaat, Jason L Kirschner, Steven A Rasmussen, Benjamin D Greenberg
OBJECTIVE: Pain remains a critical medical challenge. Current treatments target nociception without addressing affective symptoms. Medically intractable pain is sometimes treated with cingulotomy or deep brain stimulation to increase tolerance of pain-related distress. Transcranial direct current stimulation (tDCS) may noninvasively modulate cortical areas related to sensation and pain representations. The present study aimed to test the hypothesis that cathodal ("inhibitory") stimulation targeting left dorsal anterior cingulate cortex (dACC) would increase tolerance to distress from acute painful stimuli vs anodal stimulation...
August 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26113822/social-and-cultural-elements-associated-with-neurocognitive-dysfunctions-in-spinocerebellar-ataxia-type-2-patients
#18
Roberto Emmanuele Mercadillo, Víctor Galvez, Rosalinda Díaz, Lorena Paredes, Javier Velázquez-Moctezuma, Carlos R Hernandez-Castillo, Juan Fernandez-Ruiz
Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico...
2015: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/26098873/a-sensitive-and-specific-neural-signature-for-picture-induced-negative-affect
#19
Luke J Chang, Peter J Gianaros, Stephen B Manuck, Anjali Krishnan, Tor D Wager
Neuroimaging has identified many correlates of emotion but has not yet yielded brain representations predictive of the intensity of emotional experiences in individuals. We used machine learning to identify a sensitive and specific signature of emotional responses to aversive images. This signature predicted the intensity of negative emotion in individual participants in cross validation (n =121) and test (n = 61) samples (high-low emotion = 93.5% accuracy). It was unresponsive to physical pain (emotion-pain = 92% discriminative accuracy), demonstrating that it is not a representation of generalized arousal or salience...
June 2015: PLoS Biology
https://www.readbyqxmd.com/read/26072517/reassessing-cortical-reorganization-in-the-primary-sensorimotor-cortex-following-arm-amputation
#20
Tamar R Makin, Jan Scholz, David Henderson Slater, Heidi Johansen-Berg, Irene Tracey
The role of cortical activity in generating and abolishing chronic pain is increasingly emphasized in the clinical community. Perhaps the most striking example of this is the maladaptive plasticity theory, according to which phantom pain arises from remapping of cortically neighbouring representations (lower face) into the territory of the missing hand following amputation. This theory has been extended to a wide range of chronic pain conditions, such as complex regional pain syndrome. Yet, despite its growing popularity, the evidence to support the maladaptive plasticity theory is largely based on correlations between pain ratings and oftentimes crude measurements of cortical reorganization, with little consideration of potential contributions of other clinical factors, such as adaptive behaviour, in driving the identified brain plasticity...
August 2015: Brain: a Journal of Neurology
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