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Spondyloarthropathy

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https://www.readbyqxmd.com/read/28821532/cross-phenotype-association-mapping-of-the-mhc-identifies-genetic-variants-that-differentiate-psoriatic-arthritis-from-psoriasis
#1
John Bowes, James Ashcroft, Nick Dand, Farideh Jalali-Najafabadi, Eftychia Bellou, Pauline Ho, Helena Marzo-Ortega, Philip S Helliwell, Marie Feletar, Anthony W Ryan, David J Kane, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Ross McManus, Matthew A Brown, Catherine H Smith, Jonathan N Barker, Neil McHugh, Oliver FitzGerald, Richard B Warren, Anne Barton
OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility complex (MHC) that differentiate patients with PsA from patients with cutaneous psoriasis alone (PsC). METHODS: 2808 patients with PsC, 1945 patients with PsA and 8920 population controls were genotyped. We imputed SNPs, amino acids and classical HLA alleles across the MHC and tested for association with PsA compared to population controls and the PsC patient group...
August 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28814815/spondyloarthropathies-ruminococcus-on-the-horizon-in-arthritic-disease
#2
Lars Vereecke, Dirk Elewaut
No abstract text is available yet for this article.
August 17, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28798229/role-of-technetium-99m-methylene-diphosphonate-spect-ct-in-the-detection-of-sacroiliitis-in-patients-with-spondyloarthropathy-comparison-with-clinical-markers-and-mri
#3
Rahul V Parghane, Baljinder Singh, Aman Sharma, Harmandeep Singh, Paramjit Singh, Anish Bhattacharya
Rationale: To evaluate the role of (99m)Tc-MDP SPECT/CT for the detection of sacroiliitis in spondyloarthopathies (SpA) and comparison with clinical markers and MRI. Methods: A total of 155 diagnosed patients (83M : 72 F; mean age 35.80±12.40 years; range 18-60 years ) with SpA as per the European Spondyloarthropathy Study Group criteria (ESSG) criteria were prospectively included All the patients were subjected to clinical evaluation (using BASDAI scoring), ESR, CRP levels, planar (99m)Tc MDP bone scintigraphy, hybrid SPECT/CT and MRI of the pelvic region...
August 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28749173/assessment-of-sacroiliitis-for-the-diagnosis-of-spondyloarthropathy-fat-saturated-t2-weighted-imaging-with-stir-versus-fat-saturated-contrast-enhanced-t1-weighted-imaging
#4
Siyoun Sung, Hyun Su Kim, Jong Won Kwon
OBJECTIVES: To evaluate whether there is significant differences between contrastenhanced fat-saturated T1-weighted imaging and non-enhanced fat-suppression imaging for diagnosing sacroiliitis in patients with inflammatory back pain. METHODS: Ninety-two patients, consisting of 46 men and 46 women (mean age: 34 years; range: 15-63 years), who met at least four out of five Assessment in SpondyloArthritis international Society (ASAS) criteria for inflammatory low back pain were enrolled in this study...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28748512/cross-cultural-adaptation-and-validation-of-the-chinese-version-of-the-health-assessment-questionnaire-for-the-spondyloarthropathies-haq-s
#5
DeLin Liu, Chen Zhang, Chen Wang, Jiao Liu, DaHe Li, Jia Li, Weidong Xu
The Health Assessment Questionnaire for Spondyloarthropathies (HAQ-S) is a commonly used questionnaire to evaluate function and health status of patients with ankylosing spondylitis (AS). The objective of this study was to cross-culturally adapt the HAQ-S into Chinese and then to evaluate its reliability and validity. The Chinese version of the HAQ-S was obtained with a five-step procedure of translation and cross-cultural adaptation. All invited patients met the New York criteria for AS, and a total of 103 patients finally participated in this study...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28742241/cervical-epidural-injection-in-management-of-refractory-pain-and-stiffness-in-spondyloarthropathy-a-case-report-series
#6
Semih Gungor, Rohit Aiyer, Doruk Erkan
In this case report series, we present the management of three patients with cervical epidural steroid injection, who presented with neck pain and stiffness secondary to spondyloarthropathy refractory to conservative management. This article is protected by copyright. All rights reserved.
July 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28739431/protocol-optimization-of-sacroiliac-joint-mr-imaging-at-3-tesla-impact-of-coil-design-and-motion-resistant-sequences-on-image-quality
#7
P A Gondim Teixeira, M Bravetti, G Hossu, S Lecocq, D Petit, D Loeuille, A Blum
PURPOSE: To evaluate the impact of coil design and motion-resistant sequences on the quality of sacroiliac magnetic resonance imaging (MRI) examination in patients with spondyloarthropathy. PATIENTS AND METHODS: One hundred and twenty-one patients with suspected sacroiliitis and referred for MRI of the sacroiliac joints were retrospectively evaluated with MRI at 3-Tesla. There were 78 women and 43 men with a mean age of 36.7±11.5 (SD) years (range: 15.8-78.4 years)...
July 21, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28686523/clinical-utility-of-therapeutic-drug-monitoring-in-biological-disease-modifying-anti-rheumatic-drug-treatment-of-rheumatic-disorders-a-systematic-narrative-review
#8
REVIEW
Noortje Van Herwaarden, Bart J F Van Den Bemt, Maike H M Wientjes, Cornelis Kramers, Alfons A Den Broeder
Biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) have improved the treatment outcomes of inflammatory rheumatic diseases including Rheumatoid Arthritis and spondyloarthropathies. Inter-individual variation exists in (maintenance of) response to bDMARDs. Therapeutic Drug Monitoring (TDM) of bDMARDs could potentially help in optimizing treatment for the individual patient. Areas covered: Evidence of clinical utility of TDM in bDMARD treatment is reviewed. Different clinical scenarios will be discussed, including: prediction of response after start of treatment, prediction of response to a next bDMARD in case of treatment failure of the first, prediction of successful dose reduction or discontinuation in case of low disease activity, prediction of response to dose-escalation in case of active disease and prediction of response to bDMARD in case of flare in disease activity...
August 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28681364/treatment-of-a-case-of-ulcerative-colitis-with-sacroiliitis-using-granulocyte-and-monocyte-adsorption-apheresis
#9
Hitoshi Ichikawa, Jin Imai, Hajime Mizukami, Takayuki Shirai, Norihito Watanabe
In Japan, sacroiliitis is a very rare extraintestinal manifestation in patients with ulcerative colitis (UC), and it typically presents with intestinal symptoms. Radiography is used for diagnosis, and reveals erosions, sclerosis, and ankylosis, but magnetic resonance imaging is more useful for early detection. The treatment of spondyloarthropathy such as sacroiliitis and spondylitis includes physiotherapy, nonsteroidal anti-inflammatory drugs, sulfasalazine, and immunomodulators. In patients intolerant or cases refractory to these treatments, anti-tumor necrosis factor agents are recommended...
July 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28666464/animal-models-of-rheumatoid-pain-experimental-systems-and-insights
#10
REVIEW
Bradford D Fischer, Adeshina Adeyemo, Michael E O'Leary, Andrea Bottaro
Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of the neuroadaptive mechanisms acting in nociceptors and in the central nervous system in the establishment of chronic and neuropathic pain are still poorly understood, representing an area of intense study and translational priority...
June 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28662824/matrix-metalloproteinases-and-synovial-joint-pathology
#11
Charles J Malemud
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropathies. MMP gene expression is upregulated in these synovial joint pathologies in response to elevated levels of proinflammatory cytokines and soluble mediators such as tumor necrosis factor-α, interleukin-1 (IL-1), IL-6, IL-17, and interferon-γ. These molecules are capable of activating the mitogen-activated protein kinase and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways by binding the cytokine to their respective receptors on immune cells, macrophages, chondrocytes, synoviocytes, and osteocytes leading to increased synthesis of MMPs...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28660909/spondyloarthropathies-mif-drives-inflammation-and-bone-formation-in-as
#12
Sarah Onuora
No abstract text is available yet for this article.
August 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthropathy
#13
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, Jim Rosenbaum
Objective HLA-B27 associated spondyloarthropathies are associated with an altered intestinal microbiota and bowel inflammation. Therefore, we sought to identify B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2m rat and whether microbiota-derived metabolites could impact disease in this major model of spondyloarthropathy. Methods Cecal contents were collected from 6wk (pre-diseased) and 16wk (diseased) Fischer 344 HLA-B27/β2m transgenic rats and WT controls. Metabolomic profiling was performed by high-throughput gas- and liquid-chromatography-based mass spectrometry...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28592895/spondyloarthropathies-targeting-il-17-in-refractory-psa
#14
Jessica McHugh
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569265/spondyloarthropathies-gut-bone-crosstalk-in-hla-b27-rats
#15
Joanna Collison
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28556529/a-multicenter-cross-sectional-study-for-bone-articular-lesions-associated-with-dialysis-related-amyloidosis-in-japan
#16
Shinichi Nishi, Junichi Hoshino, Suguru Yamamoto, Shunsuke Goto, Hideki Fuji, Yoshifumi Ubara, Yoshihiro Motomiya, Hiroyuki Morita, Kenmei Takaichi, Kunihiro Yamagata, Takashi Shigematsu, Mitsuharu Ueda, Yukio Ando
AIM: Dialysis-related amyloidosis (DRA) exhibits multiple bone-articular lesions, such as carpal tunnel syndrome (CTS), trigger finger (TF), spinal canal stenosis (SCS), destructive spondyloarthropathy (DSA), bone cysts, and joint pains. DRA leads to a decrease in activities of daily living (ADL). We investigated the initiation of CTS and TF, and evaluated the relationship between walking disturbances and bone-articular lesions or joint pains. METHODS: A multicenter cross-sectional study was performed...
May 26, 2017: Nephrology
https://www.readbyqxmd.com/read/28551170/switching-tumor-necrosis-factor-inhibitors-in-the-treatment-of-axial-spondyloarthritis
#17
REVIEW
Atul Deodhar, David Yu
OBJECTIVE: To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA). METHODS: PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, drug survival, and TNF/tumor necrosis factor to identify published articles with data on outcomes related to switching biologic therapies in patients with axSpA...
April 25, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28546762/cardiovascular-magnetic-resonance-imaging-clinical-implications-in-the-evaluation-of-connective-tissue-diseases
#18
REVIEW
Sophie Mavrogeni, George Markousis-Mavrogenis, Loukia Koutsogeorgopoulou, Genovefa Kolovou
Cardiovascular magnetic resonance imaging is a recently developed noninvasive, nonradiating, operator-independent technique that has been successfully used for the evaluation of congenital heart disease, valvular and pericardial diseases, iron overload, cardiomyopathies, great and coronary vessel diseases, cardiac inflammation, stress-rest myocardial perfusion, and fibrosis. Rheumatoid arthritis and other spondyloarthropathies, systemic lupus erythematosus, inflammatory myopathies, mixed connective tissue diseases (CTDs), systemic sclerosis, vasculitis, and sarcoidosis are among CTDs with serious cardiovascular involvement; this is due to multiple causative factors such as myopericarditis, micro/macrovascular disease, coronary artery disease, myocardial fibrosis, pulmonary hypertension, and finally heart failure...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28541295/spondyloarthropathies-abatacept-treatment-for-psa
#19
Dario Ummarino
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28537523/the-pattern-of-uveitis-in-sri-lanka
#20
Jay Siak, Mirna Kumaradas, Soon-Phaik Chee
PURPOSE: To describe the pattern of uveitis at a tertiary uveitis referral clinic in Sri Lanka. METHODS: Consecutive charts identified from a registry between January 2010 and December 2014 at the Mediclinic Hospital, Colombo were retrospectively reviewed. RESULTS: Among 750 patients, anterior uveitis (AU) was the most common (285, 38%), followed by posterior uveitis (187, 25%), intermediate uveitis (150, 20%), and panuveitis (128, 17%). 485 (65%) were idiopathic...
May 24, 2017: Ocular Immunology and Inflammation
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