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Spondyloarthropathy

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https://www.readbyqxmd.com/read/28103205/is-the-use-of-agile-patency-capsule-prior-to-videocapsule-endoscopy-useful-in-all-patients-with-spondyloarthritis
#1
Andrada Gheorghe, Denise Carmen Mihaela Zahiu, Theodor Alexandru Voiosu, Bogdan Radu Mateescu, Mihail Radu Voiosu, Mihai Rimbaş
BACKGROUND AND AIMS: As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis. MATERIAL AND METHODS: 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28068970/quadriplegia-caused-by-an-epidural-abscess-occurring-at-the-same-level-of-cervical-destructive-spondyloarthropathy-a-case-report
#2
Jun-Seok Lee, Ji-Hyun Ryu, Jong-Tae Park, Ki-Won Kim
BACKGROUND: Destructive spondyloarthropathy (DSA) is one of the major complications in patients undergoing long-term hemodialysis. To the best of our knowledge, an epidural abscess occurring at the level of preexisting cervical DSA has not been well described in the literature. We report a unique case of quadriplegia caused by an epidural abscess occurring at the same level of preexisting cervical DSA. CASE PRESENTATION: A 49-year-old woman was transferred to our emergency department with 5 days of sepsis, drowsy mental status, and quadriplegia below the C5 level...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28065978/spontaneous-bilateral-quadriceps-rupture-in-a-patient-with-ankylosing-spondylitis-a-case-report
#3
Azib Shahid, Hafiz Shahid Mushtaq, Syed Muhammad Azfar
Ankylosing spondylitis is a prototype rheumatoid factor-negative spondyloarthropathy that causes the vertebrae to fuse making the spine less flexible, resulting in a hunched-forward posture. A 47-year-old male who was a known case of ankylosing spondylitis presented with left quadriceps rupture after raising his right foot to lightly hit a football. He was fitted with a knee immobilizer as an emergency measure. The extent of the rupture was not yet established when patient requested leave to go home. The right quadriceps was ruptured as well when he took his immobilizer off to go the bathroom...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28028958/the-effectiveness-of-exergames-in-patients-with-ankylosing-spondylitis-a-randomized-controlled-trial
#4
Ali Yavuz Karahan, Fatih Tok, Pelin Yildirim, Banu Ordahan, Gozde Turkoglu, Nilay Sahin
BACKGROUND: Exergames are a well-known type of game based on a virtual avatar's body movements. This hightech approach promotes an active lifestyle. OBJECTIVES: The aim of this randomized controlled trial was to evaluate the effects of exergames on pain, disease activity, functional capacity and quality of life in patients with ankylosing spondylitis (AS). MATERIAL AND METHODS: The study involved 60 patients, who were randomized into either the exergame group (EG) or the control group (CG)...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28027828/prognosis-and-adjacent-segment-disease-after-lumbar-spinal-fusion-surgery-for-destructive-spondyloarthropathy-in-long-term-hemodialysis-patients
#5
Keishi Maruo, Tokuhide Moriyama, Toshiya Tachibana, Shinichi Inoue, Fumihiro Arizumi, Kazuki Kusuyama, Shinichi Yoshiya
BACKGROUND: Lumbar destructive spondyloarthropathy (DSA) is a serious complication in long-term hemodialysis patients. There have not been many reports regarding the surgical management for lumbar DSA. In addition, the adjacent segment pathology after lumbar fusion surgery for DSA is unclear. The objective of this study was to assess the clinical outcome and occurrence of adjacent segmental disease (ASD) after lumbar instrumented fusion surgery for DSA in long-term hemodialysis patients...
December 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27998507/fatigue-and-psychosocial-variables-in-autoimmune-rheumatic-disease-and-chronic-fatigue-syndrome-a-cross-sectional-comparison
#6
Sheila Ali, Faith Matcham, Katherine Irving, Trudie Chalder
OBJECTIVE: Fatigue is common in autoimmune rheumatic diseases (ARD). This study compared symptom-related cognitions, beliefs, behaviours, quality of sleep, lack of acceptance and distress in participants with ARD such as rheumatoid arthritis (RA), seronegative spondyloarthropathy (SpA), and connective tissue disease (CTD), and participants with chronic fatigue syndrome (CFS). METHODS: 303 participants with RA, SpA, CTD and CFS completed questionnaire measures of fatigue, social adjustment, cognitive-behavioural responses, lack of acceptance, distress and quality of sleep...
January 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27998042/ultrasound-features-of-the-posterior-tibialis-tendon-and-peroneus-brevis-tendon-entheses-a-comparison-study-between-healthy-adults-and-inflammatory-arthritis
#7
Ian M Ward, Eugene Kissin, Gurjit Kaeley, Joshua N Scott, Michelle Newkirk, Bernard A Hildebrand, Josh Lospinoso, Minna J Kohler, Jay B Higgs
OBJECTIVES: Limited literature exists on the sonographic appearance of the posterior tibialis (PTT) and the peroneus brevis (PBT) tendon entheses. We determined the anatomic features and best imaging techniques of normal PTT and PBT using musculoskeletal ultrasound and compared these findings to subjects with inflammatory arthritis. METHODS: Adult subjects were enrolled as: healthy controls (HC), rheumatoid arthritis (RA), and spondyloarthropathy (SpA). Bilateral PTT and PBT entheses were imaged longitudinally, comparing two angles of insonation: perpendicular to the skin surface and 45˚ cephalad...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27988789/systematic-review-of-rheumatic-disease-phenotypes-and-outcomes-in-the-indigenous-populations-of-canada-the-usa-australia-and-new-zealand
#8
REVIEW
Kelle Hurd, Cheryl Barnabe
We performed a systematic review designed to characterize clinical phenotypes and outcomes in Indigenous populations with rheumatic disease to enhance the understanding of how rheumatic disease presents in Indigenous populations and allow for better projection of the healthcare needs of the communities affected. A systematic search was performed in medical (Medline, EMBASE, CINAHL), Indigenous and conference abstract databases (to June 2015). Search terms for Indigenous populations were combined with terms for inflammatory arthritis conditions, connective tissue disorders, crystal arthritis and osteoarthritis...
December 17, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27984714/il-17-blockade-in-psoriasis
#9
Patrick R Burkett, Vijay K Kuchroo
IL-17A both directly induces and synergizes with other cytokines to promote autoimmune tissue inflammation. Secukinumab and ixekizumab are monoclonal antibodies (mAb) that inhibit interleukin-17A. These two agents were recently approved for treatment of psoriasis, and secukinumab is also approved for treatment of two spondyloarthropathies, psoriatic arthritis and ankylosing spondylitis.
December 15, 2016: Cell
https://www.readbyqxmd.com/read/27966293/beh%C3%A3-et-syndrome-the-vascular-cluster
#10
Hasan Yazıcı, Emire Seyahi
Although skin-mucosa lesions are common in almost all patients with Behçet syndrome (BS), clinical properties may differ from one patient to another. Within BS, there are subsets with different organ involvement and hence probably different pathological pathways. These subsets can be described as a) solo skin-mucosa disease with no major organ involvement, b) eye disease, c) seronegative spondyloarthropathy-like disease (arthritis, enthesopathy, and folliculitis), d) Crohn-like disease, and finally the topic of this chapter: e) vascular disease...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27964794/the-role-of-the-gastrointestinal-tract-in-the-pathogenesis-of-rheumatic-diseases
#11
REVIEW
Francesco Ciccia, Angelo Ferrante, Giuliana Guggino, Giovanni Triolo
Dysregulation of the intestinal epithelial barrier in genetically susceptible individuals may lead to both intestinal and extraintestinal autoimmune disorders. There is emerging literature on the role of microbiota changes in the pathogenesis of systemic rheumatic diseases such as rheumatoid arthritis, spondyloarthropathies, and connective tissue diseases. Although the role of the gastrointestinal tract in the pathogenesis of spondyloartropathies is well defined and many studies underline the importance of gastrointestinal inflammation in modulating local and systemic inflammation, the data are inconclusive regarding the effect of dysbiosis on rheumatoid arthritis and connective tissue diseases...
October 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27940584/interleukin-22-drives-the-proliferation-migration-and-osteogenic-differentiation-of-mesenchymal-stem-cells-a-novel-cytokine-that-could-contribute-to-new-bone-formation-in-spondyloarthropathies
#12
Ahmed A El-Zayadi, Elena A Jones, Sarah M Churchman, Thomas G Baboolal, Richard J Cuthbert, Jehan J El-Jawhari, Ahmed M Badawy, Adewonuola A Alase, Yasser M El-Sherbiny, Dennis McGonagle
OBJECTIVES: The SpAs are genetically and therapeutically linked to IL-23, which in turn regulates IL-22, a cytokine that has been implicated in the regulation of new bone formation in experimental models. We hypothesize that IL-22, a master regulator of stem cells in other niches, might also regulate human mesenchymal stem cell (MSC) osteogenesis. METHODS: The effects of IL-22 on in vitro MSC proliferation, migration and osteogenic differentiation were evaluated in the presence or absence of IFN-γ and TNF (to ascertain IL-22 activity in pro-inflammatory environments)...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27936930/different-contributions-of-cdkal1-kif21b-and-lrrk2-muc19-polymorphisms-to-sapho-syndrome-rheumatoid-arthritis-ankylosing-spondylitis-and-seronegative-spondyloarthropathy
#13
Nan Li, Junfen Ma, Kai Li, Changlong Guo, Liang Ming
OBJECTIVES: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and seronegative spondyloarthropathy (SPA) are autoimmune diseases of unknown etiology, which share some clinical manifestations in common. Previous family-based investigations support genetic contributions to the susceptibility of these diseases. The current study evaluated whether three previously reported AS-associated single-nucleotide polymorphisms (SNPs), rs6908425 T>C in CDKAL1, rs11584383 T>C near KIF21B, and rs11175593 C>T near LRRK2/MUC19, have any genetic overlap across multiple autoimmune diseases including SAPHO syndrome, RA, AS, and SPA...
December 12, 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27919196/the-prevalence-of-spondyloarthropathy-in-fibromyalgia-patients
#14
Derya Kaşkari, Ahmet Eftal Yücel, Muhteşem Ağildere
OBJECTIVE: To document the prevalence of Spondyloarthropathy (SpA) with an evaluation of patients previously diagnosed with fibromyalgia syndrome (FMS). METHODS: The patients diagnosed with FMS before telephoned and asked three questions to determine for inflammatory back pain. American College of Rheumatology (ACR) Fibromyalgia criteria 1990 and ACR 2010 and for diagnosing patients with SpA; criteria from the European Spondyloarthropathy Study Group (ESSG), and Amor were applied...
December 23, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27914688/systematic-review-of-rheumatic-disease-epidemiology-in-the-indigenous-populations-of-canada-the-united-states-australia-and-new-zealand
#15
REVIEW
Cairistin McDougall, Kelle Hurd, Cheryl Barnabe
OBJECTIVE: Past publications have highlighted an excess rheumatic disease incidence and prevalence in indigenous populations of Canada (First Nations, Inuit, and Métis), and the United States of America (Alaska Native and American Indian). We have updated these reviews and expanded the scope to include New Zealand (Maori) and Australia (Aborigine) indigenous populations. METHODS: We performed a broad search using medical literature databases, indigenous specific online indexes, and government websites to identify publications reporting the incidence and/or prevalence of arthritis conditions (rheumatoid arthritis, spondyloarthropathies, gout, osteoarthritis, systemic autoimmune rheumatic diseases, and juvenile idiopathic arthritis) in the indigenous populations of Canada, America, New Zealand, and Australia...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27861762/gut-microbiome-in-children-with-enthesitis-related-arthritis-in-a-developing-country-and-the-effect-of-probiotic-administration
#16
A Aggarwal, A N Sarangi, P Gaur, A Shukla, Rakesh Aggarwal
In Asia, enthesitis-related arthritis (ERA) is the most frequent category of juvenile idiopathic arthritis. ERA has a strong association with human leucocyte antigen (HLA)-B27 and subclinical gut inflammation. In an HLA-B27 transgenic rat model, the presence of Bacteroides bacteria in the gut appears to cause spondyloarthropathy (SpA). Thus, we studied gut microbiota in children with ERA. Stool specimens from 33 patients with ERA and 14 age-matched healthy controls were studied; none had any gastrointestinal symptom, or had received a drug known to affect gut motility or microbiota in the preceding 6 weeks...
November 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27834119/correlation-of-periodontal-disease-with-inflammatory-arthritis-in-the-time-before-modern-medical-intervention
#17
Bruce Rothschild
BACKGROUND: Controversy exists as to possible correlation of periodontal disease with rheumatoid arthritis and ankylosing spondylitis. Confounding factors may relate to stringency of inflammatory disease diagnosis and to effect on periodontal disease of therapeutic intervention for rheumatoid arthritis. These were investigated. METHODS: Forty-five individuals with documented rheumatoid arthritis, spondyloarthropathy and calcium pyrophosphate deposition disease were examined from the Hamann-Todd collection of human skeletons compiled between 1912 and 1938, in addition to fifteen individuals contemporarily incorporated in the collection were examined for tooth loss, cavity occurrence, average and maximum lingual and buccal depth of the space between tooth and bone, periosteal reaction, serpentine bone resorption, abscess formation and root penetration of bone surface and analyzed by analysis of variance (ANOVA)...
November 11, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27833598/alteration-of-fecal-microbiota-profiles-in-juvenile-idiopathic-arthritis-associations-with-hla-b27-allele-and-disease-status
#18
Monica Di Paola, Duccio Cavalieri, Davide Albanese, Maddalena Sordo, Massimo Pindo, Claudio Donati, Ilaria Pagnini, Teresa Giani, Gabriele Simonini, Alessia Paladini, Paolo Lionetti, Carlotta De Filippo, Rolando Cimaz
Alteration of gut microbiota is involved in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, and gut microbial "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may be involved in spondyloarthropathies and in a subset of patients affected by Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of childhood. We compared the fecal microbiota composition of JIA patients with healthy subjects (HS), evaluating differences in microbial profiles between sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related arthritis (JIA-nERA)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27785317/facing-terminal-ileitis-going-beyond-crohn-s-disease
#19
REVIEW
Ricardo de Alvares Goulart, Sandra Maria Barbalho, Rodrigo Galhardi Gasparini, Antonely de Cassio Alves de Carvalho
Terminal ileitis (TI) is an inflammatory condition of the terminal portion of the ileum that may occur acutely with right lower quadrant pain followed or not by diarrhea, or exhibit chronic obstructive symptoms and bleeding and normally it is associated to Crohn's disease (CD) although it may be associated to other different conditions. This review intended to contribute to a better understanding of TI in order to help in the diagnosis, medical approach and patient care. This work was performed on a survey of articles collected in different databases and a retrospective search was carried out to identify relevant studies in the field...
February 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27771479/surgical-management-for-destructive-atlantoaxial-spondyloarthropathy-in-long-term-hemodialysis-patients
#20
Je Hoon Jeong, Hee Kyung Kim, Soo Bin Im
BACKGROUND: Atlantoaxial spondyloarthropathy most often results from rheumatoid arthritis, cancer metastasis, or basilar invagination. Dialysis-related spondyloarthropathy is a rare cause of spinal deformity and cervical myelopathy at the atlantoaxial joint. We report 2 patients on long-term hemodialysis who presented with atlantoaxial spondyloarthropathy. CASE DESCRIPTION: Two patients with end-stage renal failure presented with a history of progressively worsening neck pain, motion limitation, and gait disturbance...
October 19, 2016: World Neurosurgery
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