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https://www.readbyqxmd.com/read/27888190/tfap2-and-sox1-2-3-cooperatively-specify-ectodermal-fates-in-ascidian-embryos
#1
Kaoru S Imai, Hiroki Hikawa, Kenji Kobayashi, Yutaka Satou
Epidermis and neural tissues differentiate from the ectoderm in animal embryos. While epidermal fate is thought to be induced in vertebrate embryos, embryological evidence has indicated that no intercellular interactions during early stages are required for epidermal fate in ascidian embryos. To test this hypothesis, we determined the gene regulatory circuits for epidermal and neural specification in the ascidian embryo. These circuits started with Tfap2-r.b and Sox1/2/3, which are expressed in the ectodermal lineage immediately after zygotic genome activation...
November 25, 2016: Development
https://www.readbyqxmd.com/read/27811935/integrated-computational-approach-to-the-analysis-of-rna-seq-data-reveals-new-transcriptional-regulators-of-psoriasis
#2
Alena Zolotarenko, Evgeny Chekalin, Alexandre Mesentsev, Ludmila Kiseleva, Elena Gribanova, Rohini Mehta, Ancha Baranova, Tatiana V Tatarinova, Eleonora S Piruzian, Sergey Bruskin
Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis of 14 pairs of skin samples collected from patients with psoriasis. Subsequent pathway analysis and extraction of the transcriptional regulators governing psoriasis-associated pathways was executed using a combination of the MetaCore Interactome enrichment tool and the cisExpress algorithm, followed by comparison to a set of previously described psoriasis response elements...
November 4, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27259519/loss-of-ap-2delta-reduces-retinal-ganglion-cell-numbers-and-axonal-projections-to-the-superior-colliculus
#3
Xiaodong Li, Frédéric Gaillard, Elizabeth A Monckton, Darryl D Glubrecht, Amit R L Persad, Markus Moser, Yves Sauvé, Roseline Godbout
BACKGROUND: AP-2δ is the most divergent member of the Activating Protein-2 (TFAP2) family of transcription factors. AP-2δ is restricted to specific regions of the CNS, including a subset of ganglion cells in the retina. Retinal ganglion cells (RGCs), the only output neurons of the retina, are responsible for transmitting the visual signal to the brain. RESULTS: AP-2δ knockout results in loss of Brn3c (Pou4f3) expression in AP-2δ -positive RGCs. While AP-2δ-/- mice have morphologically normal retinas at birth, there is a significant reduction in retinal ganglion cell numbers by P21, after eye opening...
2016: Molecular Brain
https://www.readbyqxmd.com/read/26962893/identification-of-chromatin-accessibility-domains-in-human-breast-cancer-stem-cells
#4
K Hardy, F Wu, W Tu, A Zafar, T Boulding, R McCuaig, C R Sutton, A Theodoratos, S Rao
Epithelial-to-mesenchymal transition (EMT) is physiological in embryogenesis and wound healing but also associated with the formation of cancer stem cells (CSCs). Many EMT signaling pathways are implicated in CSC formation, but the precise underlying mechanisms of CSC formation remain elusive. We have previously demonstrated that PKC is critical for EMT induction and CSC formation in inducible breast EMT/CSC models. Here, we used formaldehyde-assisted isolation of regulatory elements-sequencing (FAIRE-seq) to investigate DNA accessibility changes after PKC activation and determine how they influence EMT and CSC formation...
2016: Nucleus
https://www.readbyqxmd.com/read/26822476/common-arterial-trunk-and-ventricular-non-compaction-in-lrp2-knockout-mice-indicate-a-crucial-role-of-lrp2-in-cardiac-development
#5
Maria E Baardman, Mathijs V Zwier, Lambertus J Wisse, Adriana C Gittenberger-de Groot, Wilhelmina S Kerstjens-Frederikse, Robert M W Hofstra, Angelika Jurdzinski, Beerend P Hierck, Monique R M Jongbloed, Rolf M F Berger, Torsten Plösch, Marco C DeRuiter
Lipoprotein-related receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts ofLrp2knockout (KO) mice have not yet been investigated. We studied the cardiovascular development ofLrp2KO mice between embryonic day 10.5 (E10.5) and E15.5, applying morphometry and immunohistochemistry, using antibodies against Tfap2α (neural crest cells), Nkx2.5 (second heart field), WT1 (epicardium derived cells), tropomyosin (myocardium) and LRP2...
April 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/26097884/methylation-changes-in-the-tfap2e-promoter-region-are-associated-with-braf-mutation-and-poorer-overall-disease-free-survival-in-colorectal-cancer
#6
Andrew D Beggs, Mark P Dilworth, Enric Domingo, Rachel Midgley, David Kerr, Ian P M Tomlinson, Gary W Middleton
INTRODUCTION: BRAF mutant colorectal cancer carries a poor prognosis which is thought to be related to poor response to conventional chemotherapy. BRAF mutation is associated with the serrated tumour phenotype. We hypothesised that one of the mechanisms by which BRAF mutant colorectal cancer demonstrate poor outcomes with chemotherapy is abnormal gene methylation. METHODS: The Cancer Genome Atlas (TCGA) methylation data was analysed using a linear regression model with BRAF mutation as an independent variable...
2015: Oncoscience
https://www.readbyqxmd.com/read/25964075/activating-enhancer-binding-protein-2-epsilon-ap-2%C3%AE%C2%B5-deficient-mice-exhibit-increased-matrix-metalloproteinase-13-expression-and-progressive-osteoarthritis-development
#7
Stephan Niebler, Thomas Schubert, Ernst B Hunziker, Anja K Bosserhoff
INTRODUCTION: The transcription factor activating enhancer binding protein 2 epsilon (AP-2ε) was recently shown to be expressed during chondrogenesis as well as in articular chondrocytes of humans and mice. Furthermore, expression of AP-2ε was found to be upregulated in affected cartilage of patients with osteoarthritis (OA). Despite these findings, adult mice deficient for AP-2ε (Tfap2e(-/-)) do not exhibit an obviously abnormal cartilaginous phenotype. We therefore analyzed embryogenesis of Tfap2e(-/-) mice to elucidate potential transient abnormalities that provide information on the influence of AP-2ε on skeletal development...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25810491/transcription-factor-ap2%C3%AE%C2%B5-a-potential-predictor-of-chemoresistance-in-patients-with-gastric-cancer
#8
Jingyue Sun, Nan Du, Jin Li, Jianwei Zhou, Guoquan Tao, Suan Sun, Jingdong He
Chemotherapy is a mainstay of therapy for advanced gastric cancer (GC); however, owing to drug resistances, the effectiveness of chemotherapy is not satisfactory for some patients with GC. Therefore, identification of a marker that predicts treatment response is beneficial to patients. Hypermethylation of transcription factor activating enhancer-binding protein 2∊ (TFAP2E) has been implicated in chemotherapy resistance to fluorouracil-based chemotherapy in patients with colorectal cancer, but its role in GC is still unknown...
April 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/25592042/gelatinases-stimuli-nanoparticles-encapsulating-5-fluorouridine-and-5-aza-2-deoxycytidine-enhance-the-sensitivity-of-gastric-cancer-cells-to-chemical-therapeutics
#9
Feng-lei Wu, Ru-Tian Li, Mi Yang, Guo-Feng Yue, Hui-yu Wang, Qin Liu, Fang-bo Cui, Pu-yuan Wu, Hui Ding, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Liu
Aberrant methylation of the transcription factor AP-2 epsilon (TFAP2E) has been attributed to 5-fluorouridine (5-FU) sensitivity. 5-Aza-2'-deoxycytidine (DAC), an epigenetic drug that inhibits DNA methylation, is able to cause reactive expression of TFAP2E by demethylating activity. This property might be useful in enhancing the sensitivity of cancer cells to 5-FU. However, the effect of DAC is transient because of its instability. Here, we report the use of intelligent gelatinases-stimuli nanoparticles (NPs) to coencapsulate and deliver DAC and 5-FU to gastric cancer (GC) cells...
July 10, 2015: Cancer Letters
https://www.readbyqxmd.com/read/25501033/mir-214-as-a-key-hub-that-controls-cancer-networks-small-player-multiple-functions
#10
REVIEW
Elisa Penna, Francesca Orso, Daniela Taverna
MicroRNAs are short regulatory RNAs that are able to post-transcriptionally modulate gene expression and that have crucial roles in the control of physiological and pathological processes including cancer onset, growth, and progression. miR-214, located inside the sequence of the long noncoding Dmn3os transcript, contributes to the regulation of normal and cancer cell biology, even if it operates in a context-dependent and sometimes contradictory manner. miR-214 is deregulated in several human tumors including melanoma, breast, ovarian, gastric, and hepatocellular carcinomas...
April 2015: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/25341849/tfap2e-methylation-status-and-prognosis-of-patients-with-radically-resected-colorectal-cancer
#11
Seong Joon Park, Seung-mi Kim, Yong Sang Hong, Jae-Lyun Lee, Jeong-Eun Kim, Kyu-pyo Kim, Seung-Mo Hong, Dong-Hoon Jin, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim, Tae Won Kim
OBJECTIVES: This study investigates the clinical significance of the gene encoding AP-2ε (TFAP2E) in colorectal cancer (CRC) patients undergoing curative resection. METHODS: A single-institution cohort of 248 patients who underwent curative resection of stage I/II/III CRCs between March and December 2004 was enrolled, and 193 patients whose tumors were available for the determination of the TFAP2E methylation status were included in the analysis. RESULTS: TFAP2E hypermethylation was detected in 112 patients (58%) and was significantly associated with distally located CRCs, low pathologic T stage (T1/T2), and stage I tumors...
2015: Oncology
https://www.readbyqxmd.com/read/24996990/tfap2e-hypermethylation-was-associated-with-survival-advantage-in-patients-with-colorectal-cancer
#12
Zuo-Ming Zhang, Yibaina Wang, Rong Huang, Yu-Peng Liu, Xia Li, Fu-Lan Hu, Lin Zhu, Fan Wang, Bin-Bin Cui, Xin-Shu Dong, Ya-Shuang Zhao
PURPOSE: Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. METHODS: We detected the methylation status of AP-2E in tumor and adjacent non-tumor tissues from 311 sporadic CRC patients by methylation-sensitive high-resolution melting analysis...
December 2014: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/24616412/transcription-factor-ap2-epsilon-tfap2e-regulates-neural-crest-specification-in-xenopus
#13
Chang-Soo Hong, Arun Devotta, Young-Hoon Lee, Byung-Yong Park, Jean-Pierre Saint-Jeannet
Transcription factors Pax3 and Zic1 are two important regulators of cell fate decision at the neural plate border, where they act synergistically to promote neural crest (NC) formation. To understand the role of these factors in NC development, we performed a microarray analysis to identify downstream targets of Pax3 and Zic1 in Xenopus embryos. Among the genes identified was a member of transcription factor activator protein 2 (Tfap2) family, Tfap2 epsilon (Tfap2e). Tfap2e is first expressed at early neurula stage in NC progenitors and Rohon-Beard sensory neurons, and persists in a subset of migrating cranial NC cells as they populate the pharyngeal arches...
September 2014: Developmental Neurobiology
https://www.readbyqxmd.com/read/24380799/an-essential-role-for-heat-shock-transcription-factor-binding-protein-1-hsbp1-during-early-embryonic-development
#14
Binnur Eroglu, Jin-Na Min, Yan Zhang, Edyta Szurek, Demetrius Moskophidis, Ali Eroglu, Nahid F Mivechi
Heat shock factor binding protein 1 (HSBP1) is a 76 amino acid polypeptide that contains two arrays of hydrophobic heptad repeats and was originally identified through its interaction with the oligomerization domain of heat shock factor 1 (Hsf1), suppressing Hsf1's transcriptional activity following stress. To examine the function of HSBP1 in vivo, we generated mice with targeted disruption of the hsbp1 gene and examined zebrafish embryos treated with HSBP1-specific morpholino oligonucleotides. Our results show that hsbp1 is critical for preimplantation embryonic development...
February 15, 2014: Developmental Biology
https://www.readbyqxmd.com/read/24115114/genome-wide-screening-of-aberrant-dna-methylation-which-associated-with-gene-expression-in-mouse-skin-cancers
#15
Kyoko Fujiwara, Srimoyee Ghosh, Ping Liang, Evan Morien, Masayoshi Soma, Hiroki Nagase
Epigenetic alteration of genomic DNA is a common and key process in carcinogenesis. There is considerable evidence indicating that some of the somatic alterations occurring during carcinogenesis in humans also involve the same processes as those observed in mice. Therefore, we analyzed mouse skin cancer tissues induced by the 2-stage carcinogenesis model to identify skin tumor-specific differentially methylated regions (ST-DMRs) during the multistep carcinogenesis process. We have previously identified ST-DMRs using the restriction landmark genomic scanning (RLGS) technique and reported that some of the mouse ST-DMRs were also epigenetically modified in human cancers, such as melanoma, neuroblastoma, and brain tumor...
March 2015: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/24002729/a-potential-new-therapeutic-approach-for-friedreich-ataxia-induction-of-frataxin-expression-with-tale-proteins
#16
Pierre Chapdelaine, Zoé Coulombe, Amina Chikh, Catherine Gérard, Jacques P Tremblay
TALEs targeting a promoter sequence and fused with a transcription activation domain (TAD) may be used to specifically induce the expression of a gene as a potential treatment for haploinsufficiency. This potential therapeutic approach was applied to increase the expression of frataxin in fibroblasts of Friedreich ataxia (FRDA) patients. FRDA fibroblast cells were nucleofected with a pCR3.1 expression vector coding for TALEFrat#8 fused with VP64. A twofold increase of the frataxin mRNA (detected by quantitative reverse transcription-PCR (qRT-PCR)) associated with a similar increase of the mature form of the frataxin protein was observed...
2013: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/23969311/identification-and-dissection-of-a-key-enhancer-mediating-cranial-neural-crest-specific-expression-of-transcription-factor-ets-1
#17
Meyer Barembaum, Marianne E Bronner
Neural crest cells form diverse derivatives that vary according to their level of origin along the body axis, with only cranial neural crest cells contributing to facial skeleton. Interestingly, the transcription factor Ets-1 is uniquely expressed in cranial but not trunk neural crest, where it functions as a direct input into neural crest specifier genes, Sox10 and FoxD3. We have isolated and interrogated a cis-regulatory element, conserved between birds and mammals, that drives reporter expression in a manner that recapitulates that of endogenous Ets-1 expression in the neural crest...
October 15, 2013: Developmental Biology
https://www.readbyqxmd.com/read/23667173/mir-214-coordinates-melanoma-progression-by-upregulating-alcam-through-tfap2-and-mir-148b-downmodulation
#18
Elisa Penna, Francesca Orso, Daniela Cimino, Irene Vercellino, Elena Grassi, Elena Quaglino, Emilia Turco, Daniela Taverna
Malignant melanoma is one of the most aggressive human cancers, but the mechanisms governing its metastatic dissemination are not fully understood. Upregulation of miR-214 and ALCAM and the loss of TFAP2 expression have been implicated in this process, with TFAP2 a direct target of miR-214. Here, we link miR-214 and ALCAM as well as identify a core role for miR-214 in organizing melanoma metastasis. miR-214 upregulated ALCAM, acting transcriptionally through TFAP2 and also posttranscriptionally through miR-148b (itself controlled by TFAP2), both negative regulators of ALCAM...
July 1, 2013: Cancer Research
https://www.readbyqxmd.com/read/23629956/genetic-risk-profiles-for-a-childhood-with-severe-overweight
#19
J R González, M N Estévez, P S Giralt, A Cáceres, L M L Pérez, M González-Carpio, F Ballester, J Sunyer, R Rodríguez-López
OBJECTIVE: The objective of this study was the description of a valid genetic risk score (GRS) to predict individuals with high susceptibility to childhood overweight by their genetic profiles. DESIGN AND METHODS: Case-control study including a group of children with high-risk familial predisposition to morbid obesity. Birth cohort from general population constituted the validation sample. For the discovery sample, 218 children with non-syndromic obesity and 190 control individuals were included...
August 2014: Pediatric Obesity
https://www.readbyqxmd.com/read/23408462/adipocytokines-levels-at-delivery-functional-variation-of-tfap2%C3%AE-and-maternal-and-neonatal-anthropometric-parameters
#20
Erika Comasco, Stavros I Iliadis, Anders Larsson, Matts Olovsson, Lars Oreland, Inger Sundström-Poromaa, Alkistis Skalkidou
OBJECTIVE: Adipocytokines participate in the regulation of glucose metabolism and fetal development. The transcription factor activating protein 2B (TFAP2β) has been associated with adipocytokine regulation, and gene variations with type 2 diabetes and obesity. This study investigated associations between maternal TFAP2B variation, adipocytokine levels, and maternal and neonatal anthropometric characteristics. DESIGN AND METHODS: A population-based sample of women was followed from delivery to 6 months postpartum...
October 2013: Obesity
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