Jelle Huysentruyt, Wolf Steels, Mario Ruiz Perez, Bruno Verstraeten, Mike Vadi, Tatyana Divert, Kayleigh Flies, Nozomi Takahashi, Bart N Lambrecht, Wim Declercq, Tom Vanden Berghe, Jonathan Maelfait, Peter Vandenabeele, Peter Tougaard
The T cell population size is stringently controlled before, during, and after immune responses, as improper cell death regulation can result in autoimmunity and immunodeficiency. RIPK1 is an important regulator of peripheral T cell survival and homeostasis. However, whether different peripheral T cell subsets show a differential requirement for RIPK1 and which programmed cell death pathway they engage in vivo remains unclear. In this study, we demonstrate that conditional ablation of Ripk1 in conventional T cells (Ripk1ΔCD4 ) causes peripheral T cell lymphopenia, as witnessed by a profound loss of naive CD4+ , naive CD8+ , and FoxP3+ regulatory T cells...
May 11, 2024: Cell Death and Differentiation