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Ankylosing spondylitis

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https://www.readbyqxmd.com/read/28803733/corrigendum-to-characteristics-of-cervical-spine-trauma-in-patients-with-ankylosing-spondylitis-and-ossification-of-the-posterior-longitudinal-ligament-world-neurosurgery-96-2016-202-208
#1
Chang Kyu Lee, Do Heum Yoon, Keung Nyun Kim, Seong Yi, Dong Ah Shin, Byeongwoo Kim, Nam Lee, Yoon Ha
No abstract text is available yet for this article.
August 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28803431/sb2-an-infliximab-biosimilar
#2
Yvette N Lamb, Lesley J Scott, Emma D Deeks
SB2 is a biosimilar of the reference anti-TNF-α antibody infliximab. In May 2015, it was approved in the EU for use in all indications for which reference infliximab is approved, including rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriatic arthritis and psoriasis. It is also approved in these indications in several other countries, including Korea, the USA and Australia. Characterization of SB2 in preclinical studies showed that it is similar to reference infliximab...
August 12, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28800602/mefv-m694v-mutation-has-a-role-in-susceptibility-to-ankylosing-spondylitis-a-meta-analysis
#3
Linqing Zhong, Hongmei Song, Wei Wang, Ji Li, Mingsheng Ma
OBJECTIVE: The aim of the current study was to determine the contributions of several common mutations in the Mediterranean fever (MEFV) gene, namely, E148Q, M680I, M694V and V726A, to ankylosing spondylitis (AS) susceptibility. METHODS: Two investigators independently searched the literature regarding the association of MEFV with AS in the PubMed, EMBASE, Web of Science, and Scopus databases. They independently selected eligible articles and then extracted data from the included studies...
2017: PloS One
https://www.readbyqxmd.com/read/28797160/ileocolonoscopic-findings-in-patients-with-ankylosing-spondylitis-a-single-center-retrospective-study
#4
Soo Min Ahn, Yong-Gil Kim, Seung-Hyeon Bae, Doo-Ho Lim, Seokchan Hong, Sang Hyoung Park, Chang-Keun Lee, Bin Yoo
Background/Aims: In some Western countries, up to 50% of patients with ankylosing spondylitis (AS) have subclinical gut inflammation. This study was conducted to evaluate the prevalence and severity of gut inflammation and to determine clinical factors associated with colonic inflammation in Korean AS patients who performed ileocolonoscopy without evidence of established inf lammatory bowel diseases before. Methods: One hundred and eight AS patients who underwent ileocolonoscopy were included in this study...
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28796721/mechanisms-predisposing-factors-and-prognosis-of-intraoperative-vertebral-subluxation-during-pedicle-subtraction-osteotomy-in-surgical-correction-of-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis
#5
Bang-Ping Qian, Sai-Hu Mao, Jun Jiang, Bin Wang, Yong Qiu
STUDY DESIGN: A retrospective study. OBJECTIVE: To analyze the mechanisms, predisposing factors, and prognosis of the intraoperative vertebral subluxation (VS) during pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: VS is one of the most daunting challenges that surgeons encounter during PSO closure, especially in patients with AS with ankylosed and mostly osteoporotic spine...
August 15, 2017: Spine
https://www.readbyqxmd.com/read/28794504/promoter-hypermethylation-of-bcl11b-gene-correlates-with-downregulation-of-gene-transcription-in-ankylosing-spondylitis-patients
#6
J Karami, M Mahmoudi, A Amirzargar, M Gharshasbi, A Jamshidi, S Aslani, M H Nicknam
Methylation of DNA is one of the important regulatory mechanisms of gene transcription. B-cell chronic lymphocytic leukemia/lymphoma 11B (BCL11B) plays a key role in the development, proliferation, differentiation, and survival of T cells. The aim of this study was to evaluate promoter methylation of BCL11B gene and its mRNA level in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis (AS) patients in relation to healthy controls and evaluate their correlation with diseases clinical indices...
August 10, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28790811/retrospective-analysis-to-describe-associations-between-tumor-necrosis-factor-alpha-inhibitors-and-copd-related-hospitalizations
#7
Neil A Accortt, James B Chung, Machaon Bonafede, Brendan L Limone, David M Mannino
BACKGROUND: Limited information exists on the impact of tumor necrosis factor inhibition on COPD exacerbations. This retrospective study characterized this impact among COPD patients with underlying autoimmune conditions, exposed to tumor necrosis factor inhibitors (TNFi) and/or non-biologic disease-modifying antirheumatic drugs (DMARDs). PATIENTS AND METHODS: Adult COPD patients with ≥1 diagnosis for rheumatoid arthritis (RA), psoriasis (PsO), psoriatic arthritis (PsA), or ankylosing spondylitis (AS) before or within 6 months following the index COPD diagnosis were identified from the Truven Health MarketScan(®) databases...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28790550/paradoxical-side-effect-related-with-anti-tumor-necrosis-factor-alpha-treatment
#8
Ayhan Aşkın, Ece Güvendi, Aliye Tosun, Ümit Seçil Demirdal
INTRODUCTION: Anti-tumor necrosis factor (anti-TNF) treatments are effective in controlling disease activity in many immune-mediated diseases such as psoriasis and ankylosing spondylitis (AS). Although side effects such as infection and skin reactions are predictable in anti-TNF treatment; susceptibility to psoriasis is considered as a paradoxical side effect. CASE REPORT: We report a case of forty-year-old male patient with 7 years of AS was taking anti-TNF therapy...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28790485/bone-wasn-t-built-in-a-day-destruction-and-formation-of-bone-in-the-rheumatic-diseases
#9
Ellen M Gravallese
The hallmark of rheumatoid arthritis is synovitis, or inflammation of synovial tissues lining joints. Synovitis in rheumatoid arthritis promotes destruction of articular bone by inducing the differentiation and function of osteoclasts, leading to significant patient morbidity. The cell types and pathways mediating articular bone destruction have now been elucidated and the critical role of receptor activator of nuclear factor-kappa B ligand has been recognized, leading to the identification of new targets for the protection of articular bone...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28783399/outcome-measures-of-disease-activity-in-inflammatory-arthritis
#10
Geraint A Brown, Alice Cotton, Jesusa Guinto, Arti Sharma, Coziana Ciurtin
The most common types of chronic inflammatory arthritis are rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. In order to assess the activity of these diseases and tailor therapy, several outcome measures have been developed. They include composite scores based on clinical findings, biochemical markers and patient questionnaires. This article discusses the most commonly used outcome measures and looks at their limitations in quantifying the complex clinical features of different types of inflammatory arthritis, focusing in particular on rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis...
August 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28780639/ethnicity-and-disease-severity-in-ankylosing-spondylitis-a-cross-sectional-analysis-of-three-ethnic-groups
#11
Farokh Jamalyaria, Michael M Ward, Shervin Assassi, Thomas J Learch, MinJae Lee, Lianne S Gensler, Matthew A Brown, Laura Diekman, Amirali Tahanan, Mohammad H Rahbar, Michael H Weisman, John D Reveille
The purpose of this study is to compare disease severity in ankylosing spondylitis (AS) in three ethnic groups. We assessed 925 AS patients (57 Blacks, 805 Whites, 63 Latinos) enrolled in the longitudinal Prospective Study of Outcomes in AS (PSOAS) for functional impairment, disease activity, and radiographic severity. Comparisons of clinical characteristics and HLA-B27 frequency for each group were performed, in two multivariable regression models, we compared the baseline Bath Ankylosing Spondylitis Radiographic Index (BASRI) and modified Stokes Ankylosing Spondylitis Spine Score (mSASSS) by ethnicity, adjusting for covariates...
August 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28774657/prevalence-of-rheumatic-diseases-in-adult-population-in-spain-episer-2016-study-aims-and-methodology
#12
Daniel Seoane-Mato, Carlos Sánchez-Piedra, Lucía Silva-Fernández, Francisca Sivera, Francisco J Blanco, Fernando Pérez Ruiz, Antonio Juan-Mas, José M Pego-Reigosa, Javier Narváez, Neus Quilis Martí, Raúl Cortés Verdú, Fred Antón-Pagés, Víctor Quevedo Vila, Gustavo Añez Sturchio, Fermín Medina Varo, María Del Mar Ruiz Tudela, Antonio Romero Pérez, Javier Ballina, Anahy Brandy García, Dolores Fábregas Canales, Teresa Font Gayá, Carolina Bordoy Ferrer, Beatriz González Álvarez, Laura Casas Hernández, Fátima Álvarez Reyes, Mónica Delgado Sánchez, Cristina Martínez Dubois, Simón Ángel Sánchez-Fernández, Luisa Marena Rojas Vargas, Paula Virginia García Morales, Alejandro Olivé, Paula Rubio Muñoz, Marta Larrosa, Noemí Navarro Ricos, Eduard Graell Martín, Eugenio Chamizo, Lara Chaves Chaparro, Sara Rojas Herrera, Jordi Pons Dolset, Miguel Ángel Polo Ostariz, Susana Ruiz-Alejos Garrido, Cristina Macía Villa, Ana Cruz Valenciano, María Luisa González Gómez, Mercedes Morcillo Valle, Deseada Palma Sánchez, María José Moreno Martínez, Marta Mayor González, Joana Atxotegi Sáenz de Buruaga, Irati Urionagüena Onaindia, Boris Anthony Blanco Cáceres, Federico Díaz-González, Sagrario Bustabad
AIMS: To describe the methodology of the EPISER 2016 (study of the prevalence of rheumatic diseases in adult population in Spain), as well its strengths and limitations. The aim of this study is to estimate the prevalence of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), osteoarthritis (knee, hip, hands, and cervical and lumbar spine), fibromyalgia, gout and clinical osteoporotic fracture...
July 31, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28774456/conventional-radiology-in-spondyloarthritis
#13
REVIEW
Alberto Bazzocchi, Maria Pilar Aparisi Gómez, Giuseppe Guglielmi
Spondyloarthritides are of a group of inflammatory rheumatic diseases, with negative rheumatoid factor, associated with the HLA-B27 gene. They comprise ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic-related spondylitis. The presence of sacroiliitis represents the most characteristic feature of these disorders and is an important criterion in diagnosis. Nonradiographic axial spondyloarthritis is a new classification concept. Conventional radiography is recommended as the first imaging method to diagnose sacroiliitis and different entities and to monitor established structural changes...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28770712/two-year-retention-rate-of-golimumab-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis-data-from-the-lorhen-registry
#14
Maria Manara, Roberto Caporali, Ennio G Favalli, Vittorio Grosso, Fabiola Atzeni, Piercarlo Sarzi Puttini, Roberto Gorla, Chiara Bazzani, Enrico Fusaro, Raffaele Pellerito, Pier Andrea Rocchetta, Luigi Sinigaglia
OBJECTIVES: We aimed to provide data on golimumab real-life use in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) from a multicentre observational registry of Northern Italy. METHODS: We extracted data of patients who started treatment with golimumab from October 2010, and who had at least one follow-up visit. Data were analysed until a maximum follow-up of 24 months. The two-year retention rate in the three diseases was assessed with Kaplan-Meier estimators...
July 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28767437/rs2841277-pld4-is-associated-with-susceptibility-and-rs4672495-is-associated-with-disease-activity-in-rheumatoid-arthritis
#15
Wei-Chiao Chen, Wen-Chang Wang, Hsing-Fang Lu, Yukinori Okada, Wei-Pin Chang, Yii-Her Chou, Hui-Hua Chang, Jin-Ding Huang, Der-Yuan Chen, Wei-Chiao Chang
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, can lead to long-term joint damage, chronic pain, and loss of motor function in the hands, and may share some common genetic factors with other autoimmune disorders, such as ankylosing spondylitis (AS). Many single-nucleotide polymorphisms (SNPs) were reported by genome-wide association studies (GWASs) of RA, but some of them have not been examined in the Taiwanese population. In this study, for 15 SNPs reported in previous RA and AS GWASs, we investigated their association with RA in a Taiwanese population...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766758/comparisons-of-neutrophil-monocyte-eosinophil-and-basophil-lymphocyte-ratios-among-various-systemic-autoimmune-rheumatic-diseases
#16
Zaixing Yang, Zhiyu Zhang, Feng Lin, Yingpeng Ren, Donghong Liu, Renqian Zhong, Yan Liang
This study was aimed to evaluate levels of neutrophil- (NLR), monocyte- (MLR), eosinophil- (ELR), and basophil-lymphocyte ratio (BLR) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total of 1139 SARD patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted. NLR and MLR were significantly increased, but BLR decreased in most SARD patients (p < 0.05). ELR were significantly decreased in systemic lupus erythematosus (SLE) patients, but increased in those with other SARDs (p < 0...
August 2, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28765802/clinical-gait-analysis-on-a-patient-undergoing-surgical-correction-of-kyphosis-from-severe-ankylosing-spondylitis
#17
Ram Haddas, Theodore Belanger
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton, including the sacroiliac joints, costovertebral joints, and the spine. Patients with AS found to have an alter gait pattern. The purpose of this study was to investigate biomechanical alterations in gait after surgical correction in a patient with severe kyphosis from AS. METHODS: A case report in controlled laboratory study, a pretest-posttest design...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765244/five-potentially-modifiable-factors-predict-poor-quality-of-life-in-ankylosing-spondylitis-results-from-the-scotland-registry-for-ankylosing-spondylitis
#18
Linda E Dean, Gary J Macfarlane, Gareth T Jones
OBJECTIVE: A chronic inflammatory condition manifesting in young adulthood, ankylosing spondylitis (AS) affects both physical and emotional quality of life (QOL). To inform future intervention strategies, this study aimed to (1) assess the QOL of patients with AS, and (2) identify potentially modifiable factors associated with reporting poor QOL. METHODS: The Scotland Registry for Ankylosing Spondylitis collects clinical and patient-reported data on clinically diagnosed patients with AS across Scotland...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28764693/the-relationship-between-demographic-and-disease-related-variables-and-health-related-quality-of-life-in-patients-with-axial-spondyloarthritis
#19
Gudrun Rohde, Kari Hansen Berg, Anne Prøven, Glenn Haugeberg
BACKGROUND: Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this chronic disease can reduce the quality of life. We aimed to explore the relationship between demographic- and disease-related variables and health-related quality of life (HRQoL) in patients with ax-SpA. METHODS: Demographic- and disease-related, HRQoL-related and treatment data were collected...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28761997/determinants-of-satisfaction-following-total-hip-arthroplasty-in-patients-with-ankylosing-spondylitis
#20
Lu Ding, Yu-Hang Gao, Ye-Ran Li, Jan-Guo Liu, Shu-Qiang Li, Xin Qi
BACKGROUND: The aim was to explore the factors contributing to a high degree of satisfaction following total hip arthroplasty in patients with ankylosing spondylitis and hip joint fusion. METHODS: From January 2001 to June 2015, 43 patients with ankylosing spondylitis were treated with total hip arthroplasty. The patients were divided into two groups, including 20 patients in non-fusion groups, with 25 cases of hip non-fusion, and 23 patients in fusion groups, with 40 cases of hip fusion...
July 31, 2017: International Orthopaedics
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