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https://www.readbyqxmd.com/read/28444949/voxel-based-morphometry-meta-analysis-of-gray-and-white-matter-finds-significant-areas-of-differences-in-bipolar-patients-from-healthy-controls
#1
REVIEW
Rossana Ganzola, Simon Duchesne
OBJECTIVE: We present a retrospective meta-analysis of voxel-based morphometry (VBM) of gray (GM) and white matter (WM) differences between patients with bipolar disorder (BD) and behaviorally healthy controls. METHODS: We used the activation likelihood estimation and Sleuth software for our meta-analysis, considering P-value maps at the cluster level inference of .05 with uncorrected P<.001. Results were visualized with the software MANGO. RESULTS: We included twenty-five articles in the analysis, and separated the comparisons where BD patients had lower GM or WM concentrations than controls (573 subjects, 21 experiments, and 117 locations/180 subjects, five experiments, and 15 locations, respectively) and the comparisons where BD patients had greater GM concentrations than controls (217 subjects, nine experiments, and 49 locations)...
April 26, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28437669/white-matter-microstructural-abnormalities-and-their-association-with-anticipatory-anhedonia-in-depression
#2
Xin-Hua Yang, Yi Wang, Dong-Fang Wang, Kai Tian, Eric F C Cheung, Guang-Rong Xie, Raymond C K Chan
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients...
April 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28422895/diffusion-tensor-tractography-for-detection-of-concomitant-traumatic-brain-injury-in-patients-with-traumatic-spinal-cord-injury
#3
Sung Ho Jang, Sang Ho Ahn, Yun Woo Cho, Ji Woon Lim, Ik Tae Cho
OBJECTIVES: We investigated concomitant traumatic brain injury in patients with traumatic spinal cord injury (TSCI) who had head trauma history, using diffusion tensor tractography (DTT). DESIGN: Retrospective survey. PARTICIPANTS: We recruited 14 consecutive patients with TSCI and coexisting head trauma history at the time of TSCI and 30 control subjects. METHODS: The corticospinal tract (CST), corticoreticulospinal tract (CRT), cingulum, and fornix were reconstructed using DTT, and DTT parameters (fractional anisotropy and fiber volume) and configuration were estimated...
January 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28419638/a-diffusion-tensor-imaging-tractography-study-in-bipolar-disorder-patients-compared-to-first-degree-relatives-and-healthy-controls
#4
Ananya Mahapatra, Sudhir Kumar Khandelwal, Pratap Sharan, Ajay Garg, N K Mishra
AIM: To compare white matter structural changes in specific tracts by diffusion tensor imaging (DTI) tractography in patients of bipolar disorder I, non-ill first degree relatives of the patients, and healthy controls. METHODS: In a cross sectional study, we studied right-handed subjects consisting of 16 euthymic bipolar disorder I patients, 15 first degree relatives and 15 healthy controls. The anterior thalamic radiation, uncinate fasciculus, corpus callosum, and cingulum bundle were reconstructed by DTI tractography...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28413981/default-mode-network-connectivity-and-related-white-matter-disruption-in-type-2-diabetes-mellitus-patients-concurrent-with-amnestic-mild-cognitive-impairment
#5
Di Qi, Ailin Wang, Yaojing Chen, Kewei Chen, Sisi Zhang, Junying Zhang, Xin Li, Lin Ai, Zhanjun Zhang
BACKGROUND: As a risk factor for Alzheimer's disease (AD), Type 2 diabetes mellitus (T2DM) itself causes cognitive impairment and has higher prevalence of mild cognitive impairment (MCI). OBJECTIVE: The aim of this study was to explore the cognition especially the episodic memory difference, the DMN functional connectivity and DMN-related white matter integrity in patients with both T2DM and amnestic MCI (T2DM-MCI) as compared to patients with T2DM only. METHOD: Focusing especially on T2DM population, we investigated the default mode network (DMN) through resting functional magnetic resonance imaging among 22 elderly T2DM-MCI patients and 24 elderly T2DM patients...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28401151/white-matter-integrity-in-genetic-high-risk-individuals-and-first-episode-schizophrenia-patients-similarities-and-disassociations
#6
Yifang Zhou, Jie Liu, Naomi Driesen, Fay Womer, Kaiyuan Chen, Ye Wang, Xiaowei Jiang, Qian Zhou, Chuan Bai, Dahai Wang, Yanqing Tang, Fei Wang
White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ). Understanding these variations may elucidate distinct markers of genetic vulnerability and conversion to psychosis. To examine the similarities and differences in WM connectivity between those at-risk for and in early stages of SZ, a cross-sectional diffusion tensor imaging study of 48 individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic individuals at a high genetic risk of SZ (GHR-SZ), and 67 healthy controls (HC) was conducted...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28397839/a-connectomic-approach-for-subcallosal-cingulate-deep-brain-stimulation-surgery-prospective-targeting-in-treatment-resistant-depression
#7
P Riva-Posse, K S Choi, P E Holtzheimer, A L Crowell, S J Garlow, J K Rajendra, C C McIntyre, R E Gross, H S Mayberg
Target identification and contact selection are known contributors to variability in efficacy across different clinical indications of deep brain stimulation surgery. A retrospective analysis of responders to subcallosal cingulate deep brain stimulation (SCC DBS) for depression demonstrated the common impact of the electrical stimulation on a stereotypic connectome of converging white matter bundles (forceps minor, uncinate fasciculus, cingulum and fronto-striatal fibers). To test the utility of a prospective connectomic approach for SCC DBS surgery, this pilot study used the four-bundle tractography 'connectome blueprint' to plan surgical targeting in 11 participants with treatment-resistant depression...
April 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28396646/regional-gray-matter-volume-is-associated-with-restrained-eating-in-healthy-chinese-young-adults-evidence-from-voxel-based-morphometry
#8
Yanhua Su, Todd Jackson, Dongtao Wei, Jiang Qiu, Hong Chen
Highlight Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Objective: Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28395413/-study-on-age-and-white-matter-neuronal-integrity-in-healthy-volunteers-based-on-automating-fiber-tract-quantification
#9
W P Li, F F Wang, X Zhang, M Li, J M Lu, S C Wu, B Zhang
Objective: To analyze age-related change in cerebral matter tract, especially fractional anisotropy, based on automating fiber-tract quantification(AFQ). Methods: A total of 64 years old normal persons and 43 young volunteers were enrolled respectively from the Affiliated Drum Tower Hospital of Nanjing University Medical School and community from January 2015 to June 2016.All of them underwent MRI scan, which included DTI and 3D T(1)WI sequence .All cases were divided into 3 groups according to their ages, the young group 20-35 years old, the middle old group 60-75 years old, the old group 76-90 years old...
April 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28389024/accuracy-of-a-digital-removable-partial-denture-fabricated-by-casting-a-rapid-prototyped-pattern-a-clinical-study
#10
Jong-Won Lee, Ji-Man Park, Eun-Jin Park, Seong-Joo Heo, Jai-Young Koak, Seong-Kyun Kim
STATEMENT OF PROBLEM: A limited number of clinical studies have evaluated the accuracy of a digitally generated removable partial denture (RPD) intraorally. An analysis of the accuracy of the digital RPD on a larger number of participants was needed. PURPOSE: The purpose of this clinical study was to analyze the accuracy of digital RPDs by using the replica technique. MATERIAL AND METHODS: The fit accuracy of digital RPDs fabricated using electronic surveying was analyzed by fabricating replicas with silicone registration material and measuring with a stereomicroscope and image program...
April 4, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28388630/effectiveness-of-diffusion-tensor-imaging-in-differentiating-early-stage-subcortical-ischemic-vascular-disease-alzheimer-s-disease-and-normal-ageing
#11
Min-Chien Tu, Chung-Ping Lo, Ching-Feng Huang, Yen-Hsuan Hsu, Wen-Hui Huang, Jie Fu Deng, Yung-Chuan Lee
OBJECTIVE: To describe and compare diffusion tensor imaging (DTI) parameters between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) diagnosed using structuralized neuropsychiatric assessments, and investigate potential neuronal substrates related to cognitive performance. METHODS: Thirty-five patients with SIVD, 40 patients with AD, and 33 cognitively normal control (NC) subjects matched by age and education level were consecutively recruited and underwent cognitive function assessments and DTI examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28384535/effects-of-abstinence-and-chronic-cigarette-smoking-on-white-matter-microstructure-in-alcohol-dependence-diffusion-tensor-imaging-at-4t
#12
Yukai Zou, Donna E Murray, Timothy C Durazzo, Thomas P Schmidt, Troy A Murray, Dieter J Meyerhoff
BACKGROUND: We previously reported widespread microstructural deficits of brain white matter in alcohol-dependent individuals (ALC) compared to light drinkers in a small 1.5T diffusion tensor imaging study employing tract-based spatial statistics. Using a larger dataset acquired at 4T, the present study is an extension that investigated the effects of alcohol consumption, abstinence from alcohol, and comorbid cigarette smoking on white matter microstructure. METHODS: Tract-based spatial statistics were performed on 20 1-week-abstinent ALC, 52 1-month-abstinent ALC, and 30 controls...
March 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28373835/no-evidence-that-short-term-cognitive-or-physical-training-programs-or-lifestyles-are-related-to-changes-in-white-matter-integrity-in-older-adults-at-risk-of-dementia
#13
Patrick Fissler, Hans-Peter Müller, Olivia C Küster, Daria Laptinskaya, Franka Thurm, Alexander Woll, Thomas Elbert, Jan Kassubek, Christine A F von Arnim, Iris-Tatjana Kolassa
Cognitive and physical activities can benefit cognition. However, knowledge about the neurobiological mechanisms underlying these activity-induced cognitive benefits is still limited, especially with regard to the role of white matter integrity (WMI), which is affected in cognitive aging and Alzheimer's disease. To address this knowledge gap, we investigated the immediate and long-term effects of cognitive or physical training on WMI, as well as the association between cognitive and physical lifestyles and changes in WMI over a 6-month period...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28369662/early-pleistocene-hominin-deciduous-teeth-from-the-homo-antecessor-gran-dolina-td6-bearing-level-sierra-de-atapuerca-spain
#14
José María Bermúdez de Castro, María Martinón-Torres, Laura Martín-Francés, Marina Martínez de Pinillos, Mario Modesto-Mata, Cecilia García-Campos, Xiujie Wu, Song Xing, Wu Liu
OBJECTIVES: During the last 13 years, the late Early Pleistocene Gran Dolina-TD6-2 level (Sierra de Atapuerca, northern Spain) has yielded an additional sample of 26 dental specimens attributed to Homo antecessor. In this report, we present a descriptive and comparative study of the six deciduous teeth. METHODS: We provide external and internal morphological descriptions following classical terminology, as well as the mesiodistal and buccolingual measurements of the teeth...
March 31, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28358656/dynamics-of-white-matter-plasticity-underlying-working-memory-training-multimodal-evidence-from-diffusion-mri-and-t2-relaxometry
#15
Claudia Metzler-Baddeley, Sonya Foley, Silvia de Santis, Cyril Charron, Adam Hampshire, Karen Caeyenberghs, Derek K Jones
Adaptive working memory (WM) training may lead to cognitive benefits that are associated with white matter plasticity in parietofrontal networks, but the underlying mechanisms remain poorly understood. We investigated white matter microstructural changes after adaptive WM training relative to a nonadaptive comparison group. Microstructural changes were studied in the superior longitudinal fasciculus, the main parietofrontal connection, and the cingulum bundle as a comparison pathway. MRI-based metrics were the myelin water fraction and longitudinal relaxation rate R1 from multicomponent T2 relaxometry (captured with the mcDESPOT approach) as proxy metrics of myelin, the restricted volume fraction from the composite hindered and restricted model of diffusion as an estimate of axon morphology, and fractional anisotropy and radial diffusivity from diffusion tensor imaging...
March 30, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28357562/in-vivo-imaging-of-oxidative-stress-and-fronto-limbic-white-matter-integrity-in-young-adults-with-mood-disorders
#16
Daniel F Hermens, Sean N Hatton, Rico S C Lee, Sharon L Naismith, Shantel L Duffy, G Paul Amminger, Manreena Kaur, Elizabeth M Scott, Jim Lagopoulos, Ian B Hickie
Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders...
March 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28342644/steeper-slope-of-age-related-changes-in-white-matter-microstructure-and-processing-speed-in-bipolar-disorder
#17
Sheena I Dev, Tanya T Nguyen, Benjamin S McKenna, Ashley N Sutherland, Hauke Bartsch, Rebecca J Theilmann, Lisa T Eyler
OBJECTIVES: Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging...
February 16, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28342092/evaluation-of-structural-connectivity-changes-in-betel-quid-chewers-using-generalized-q-sampling-mri
#18
Jun-Cheng Weng, Te-Wei Kao, Guo-Joe Huang, Yeu-Sheng Tyan, Hsien-Chun Tseng, Ming-Chou Ho
RATIONALE: Betel quid (BQ) is a common addictive substance in many Asian countries. However, few studies have focused on the influences of BQ on the brain. It remains unclear how BQ can affect structural brain abnormalities in BQ chewers. OBJECTIVES: We aimed to use generalized q-sampling imaging (GQI) to evaluate the impact of the neurological structure of white matter caused by BQ. METHODS: The study population comprised 16 BQ chewers, 15 tobacco and alcohol controls, and 17 healthy controls...
March 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28341872/childhood-adversity-associated-with-white-matter-alteration-in-the-corpus-callosum-corona-radiata-and-uncinate-fasciculus-of-psychiatrically-healthy-adults
#19
Simon McCarthy-Jones, Lena K L Oestreich, Amanda E Lyall, Zora Kikinis, Dominick T Newell, Peter Savadjiev, Martha E Shenton, Marek Kubicki, Ofer Pasternak, Thomas J Whitford
Diffusion tensor imaging studies report childhood adversity (CA) is associated with reduced fractional anisotropy (FA) in multiple white matter tracts in adults. Reduced FA may result from changes in tissue, suggesting myelin/axonal damage, and/or from increased levels of extracellular free-water, suggesting atrophy or neuroinflammation. Free-water imaging can separately identify FA in tissue (FAT) and the fractional volume of free-water (FW). We tested whether CA was associated with altered FA, FAT, and FW in seven white matter regions of interest (ROI), in which FA changes had been previously linked to CA (corona radiata, corpus callosum, fornix, cingulum bundle: hippocampal projection, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus)...
March 25, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28337409/network-degeneration-and-dysfunction-in-presymptomatic-c9orf72-expansion-carriers
#20
Suzee E Lee, Ana C Sias, Maria Luisa Mandelli, Jesse A Brown, Alainna B Brown, Anna M Khazenzon, Anna A Vidovszky, Theodore P Zanto, Anna M Karydas, Mochtar Pribadi, Deepika Dokuru, Giovanni Coppola, Dan H Geschwind, Rosa Rademakers, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seeley
Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dementia, but it remains unknown how early in the lifespan these and other changes in brain structure and function arise...
2017: NeuroImage: Clinical
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