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https://www.readbyqxmd.com/read/28337409/network-degeneration-and-dysfunction-in-presymptomatic-c9orf72-expansion-carriers
#1
Suzee E Lee, Ana C Sias, Maria Luisa Mandelli, Jesse A Brown, Alainna B Brown, Anna M Khazenzon, Anna A Vidovszky, Theodore P Zanto, Anna M Karydas, Mochtar Pribadi, Deepika Dokuru, Giovanni Coppola, Dan H Geschwind, Rosa Rademakers, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seeley
Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dementia, but it remains unknown how early in the lifespan these and other changes in brain structure and function arise...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28317947/parietal-operculum-and-motor-cortex-activities-predict-motor-recovery-in-moderate-to-severe-stroke
#2
Firdaus Fabrice Hannanu, Thomas A Zeffiro, Laurent Lamalle, Olivier Heck, Félix Renard, Antoine Thuriot, Alexandre Krainik, Marc Hommel, Olivier Detante, Assia Jaillard
While motor recovery following mild stroke has been extensively studied with neuroimaging, mechanisms of recovery after moderate to severe strokes of the types that are often the focus for novel restorative therapies remain obscure. We used fMRI to: 1) characterize reorganization occurring after moderate to severe subacute stroke, 2) identify brain regions associated with motor recovery and 3) to test whether brain activity associated with passive movement measured in the subacute period could predict motor outcome six months later...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28294478/the-predictive-value-of-dorsal-cingulate-activity-and-fractional-anisotropy-on-long-term-ptsd-symptom-severity
#3
Mitzy Kennis PhD, Sanne J H van Rooij PhD, Alieke Reijnen MSc, Elbert Geuze PhD
BACKGROUND: Posttraumatic stress disorder (PTSD) can be treated with trauma-focused therapy, although only about 50% of the patients recover on the short-term. In order to improve response rates it is important to identify who will and will not recover from trauma-focused therapy. Although previous studies reported dorsal anterior cingulate cortex (ACC) activity, as well as dorsal cingulum bundle white matter microstructure integrity as markers for the persistence of PTSD symptoms on the short-term, it remains unclear whether these markers also predict long-term PTSD symptom severity...
March 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28292689/white-matter-crossing-fiber-microstructure-in-adolescents-prenatally-exposed-to-cocaine
#4
Kristen P Morie, Sarah W Yip, Zu Wei Zhai, Jiansong Xu, Kristen R Hamilton, Rajita Sinha, Linda C Mayes, Marc N Potenza
BACKGROUND: Prenatal cocaine exposure (PCE) is associated with risk-taking behaviors, including increased initiation of substance use in adolescence. The neurobiological underpinnings of these behaviors in adolescents with PCE are not well understood. The goal of this study was to compare diffusion-weighted imaging data between adolescents with and without PCE using crossing-fiber models, which may provide more comprehensive estimates of white-matter microstructure within regions of multiple (e...
February 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28289940/the-effect-of-hippocampal-function-volume-and-connectivity-on-posterior-cingulate-cortex-functioning-during-episodic-memory-fmri-in-mild-cognitive-impairment
#5
Janne M Papma, Marion Smits, Marius de Groot, Francesco U Mattace Raso, Aad van der Lugt, Henri A Vrooman, Wiro J Niessen, Peter J Koudstaal, John C van Swieten, Frederik M van der Veen, Niels D Prins
OBJECTIVES: Diminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer's disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI). METHOD: MCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28268523/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#6
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28241047/hippocampal-ca3-activation-alleviates-fmri-bold-responses-in-the-rat-prefrontal-cortex-induced-by-electrical-vta-stimulation
#7
Thomas Scherf, Frank Angenstein
Functional magnetic resonance imaging (fMRI) was used to identify brain- wide networks that are activated by electrical stimulation of either the ventral tegmental area (VTA) or hippocampal CA3 region. Stimulation of either one of these regions caused significant BOLD responses in common structures, such as the septum and left and right hippocampus, but also in unique structures, such as the medial prefrontal cortex region/anterior cingulum region (mPFC/ACC) and striatum, which were only activated during VTA stimulation...
2017: PloS One
https://www.readbyqxmd.com/read/28239946/a-voxel-based-diffusion-tensor-imaging-study-in-unipolar-and-bipolar-depression
#8
Jonathan Repple, Susanne Meinert, Dominik Grotegerd, Harald Kugel, Ronny Redlich, Katharina Dohm, Dario Zaremba, Nils Opel, Christian Buerger, Katharina Förster, Theresa Nick, Volker Arolt, Walter Heindel, Michael Deppe, Udo Dannlowski
OBJECTIVE: The absence of neurobiological diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We investigated if changes in fractional anisotropy (FA) could help to differentiate BD from UD in the state of depression. METHODS: Using diffusion tensor imaging (DTI) we employed a voxel-based analysis approach to examine fractional anisotropy (FA) in 86 patients experiencing an acute major depressive episode according to DSM-IV (N=39 BD, mean age 39...
February 27, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28239791/mri-study-for-the-features-of-brain-conduction-pathways-in-patients-with-an-ultra-high-risk-of-endogenous-psychoses
#9
A S Tomyshev, I S Lebedeva, T A Akhadov, M A Omel'chenko, M V Ublinskii, N A Semenova, V G Kaleda
Diffusion parameters of brain tracts (n=18) were studied in 27 men with ultra-high risk of endogenous attack-like psychoses and 27 mentally healthy men of the same age group (fractional anisotropy; and average, radial, and axial diffusion). Correlation analysis was performed between these parameters and severity of mental disorders (SOPS scale). The indexes of radial diffusion and axial diffusion were shown to change in the left anterior thalamic radiation and right posterior cingulum bundle, respectively. Our results are consistent with published data that disturbances in the frontal and temporal lobes play an important role in the pathogenesis of schizophrenia...
February 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28238188/microglia-activation-and-phagocytosis-relationship-with-aging-and-cognitive-impairment-in-the-rhesus-monkey
#10
Eli Shobin, Michael P Bowley, Larissa I Estrada, Nadine C Heyworth, Mary E Orczykowski, Sherri A Eldridge, Samantha M Calderazzo, Farzad Mortazavi, Tara L Moore, Douglas L Rosene
While cognitive decline is observed in the normal aging monkey, neurons are not lost with age. Instead, frontal white matter is lost as myelin degenerates and both correlate with age-related cognitive decline. As age-related myelin damage increases, there should be an increase in clearance of damaged myelin by microglial phagocytosis. In this study, brains of behaviorally tested rhesus monkeys were assessed using unbiased stereology to quantify the density of activated microglia (LN3 antibody positive) and phagocytic microglia (galectin-3 (Gal-3) antibody positive) in three white matter regions: the corpus callosum, cingulum bundle (CGB), and frontal white matter (FWM)...
February 25, 2017: Geroscience
https://www.readbyqxmd.com/read/28228732/c-terminus-methionene-specifically-involved-in-binding-corn-odorants-to-odorant-binding-protein4-in-macrocentrus-cingulum
#11
Tofael Ahmed, Tiantao Zhang, Zhenying Wang, Kanglai He, Shuxiong Bai
The soluble carrier proteins, OBPs carry odor components through sensilium lymph to specific receptors within the antennal sensilla to trigger behavioral responses. Herein, McinOBP4 was characterized from the Macrocentrus cingulum, which is the specialist parasitic insect of Ostrinia furnacalis for better understanding of olfactory recognition mechanism of this wasp. The classical odorant binding protein McinOBP4 showed good binding affinity to corn green leaf volatiles. RT-qPCR results showed that the McinOBP4 was primarily expressed in male and female wasp antennae, with transcripts levels differing by sex...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28226697/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#12
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Farzaneh Rahmani, Atefeh Pooyan, Mina Ansari, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219492/microstructural-white-matter-alterations-in-the-corpus-callosum-of-girls-with-conduct-disorder
#13
Willeke Martine Menks, Reto Furger, Claudia Lenz, Lynn Valérie Fehlbaum, Christina Stadler, Nora Maria Raschle
OBJECTIVE: Diffusion tensor imaging (DTI) studies in adolescent conduct disorder (CD) have demonstrated white matter alterations of tracts connecting functionally distinct fronto-limbic regions, but only in boys or mixed-gender samples. So far, no study has investigated white matter integrity in girls with CD on a whole-brain level. Therefore, our aim was to investigate white matter alterations in adolescent girls with CD. METHOD: We collected high-resolution DTI data from 24 girls with CD and 20 typically developing control girls using a 3T magnetic resonance imaging system...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28216430/white-matter-alterations-to-cingulum-and-fornix-following-very-preterm-birth-and-their-relationship-with-cognitive-functions
#14
Chiara Caldinelli, Sean Froudist-Walsh, Vyacheslav Karolis, Chieh-En Tseng, Matthew P Allin, Muriel Walshe, Marion Cuddy, Robin M Murray, Chiara Nosarti
Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between structural connectivity in memory-related tracts and various aspects of memory in VPT adults (mean age 19) who sustained differing degrees of perinatal brain injury (PBI), as assessed by neonatal cerebral ultrasound. We showed that the neurodevelopmental consequences of VPT birth persist into young adulthood and are associated with neonatal cranial ultrasound classification...
February 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28210542/dynamic-association-between-perfusion-and-white-matter-integrity-across-time-since-injury-in-veterans-with-history-of-tbi
#15
Alexandra L Clark, Katherine J Bangen, Scott F Sorg, Dawn M Schiehser, Nicole D Evangelista, Benjamin McKenna, Thomas T Liu, Lisa Delano-Wood
OBJECTIVE: Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Although both CBF and white matter microstructural alterations have been observed within the context of traumatic brain injury (TBI), the degree to which these pathological changes relate to one another and whether this association is altered by time since injury have not been examined. The current study therefore sought to clarify associations between resting CBF and white matter microstructure post-TBI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28209179/the-social-brain-network-in-22q11-2-deletion-syndrome-a-diffusion-tensor-imaging-study
#16
Amy K Olszewski, Zora Kikinis, Christie S Gonzalez, Ioana L Coman, Nikolaos Makris, Xue Gong, Yogesh Rathi, Anni Zhu, Kevin M Antshel, Wanda Fremont, Marek R Kubicki, Sylvain Bouix, Martha E Shenton, Wendy R Kates
BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Both individuals with 22q11.2DS and those with schizophrenia present with social cognitive deficits, which are putatively subserved by a network of brain regions that are involved in the processing of social cognitive information. This study used two-tensor tractography to examine the white matter tracts believed to underlie the social brain network in a group of 57 young adults with 22q11...
February 16, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28203528/persistent-amygdala-novelty-response-is-associated-with-less-anterior-cingulum-integrity-in-trauma-exposed-women
#17
Seungyeon A Yoon, Mariann R Weierich
OBJECTIVES: We investigated the potential role of cingulum and uncinate fasciculus integrity in trauma-related neural hypervigilance, indexed by less discrimination between amygdala activation to novel and familiar affective images. PARTICIPANTS: 22 women (mean age 21.7 ± 3.9 years) with a history of trauma, and 20 no-trauma controls (mean age 21.9 ± 4.8 years). MEASURES: Trauma exposure and trauma-related symptoms were assessed during structured clinical interview...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180079/white-matter-tract-abnormalities-and-antisocial-behavior-a-systematic-review-of-diffusion-tensor-imaging-studies-across-development
#18
REVIEW
Rebecca Waller, Hailey L Dotterer, Laura Murray, Andrea M Maxwell, Luke W Hyde
Antisocial behavior (AB), including aggression, violence, and theft, is thought be underpinned by abnormal functioning in networks of the brain critical to emotion processing, behavioral control, and reward-related learning. To better understand the abnormal functioning of these networks, research has begun to investigate the structural connections between brain regions implicated in AB using diffusion tensor imaging (DTI), which assesses white-matter tract microstructure. This systematic review integrates findings from 22 studies that examined the relationship between white-matter microstructure and AB across development...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28173729/structural-and-functional-abnormalities-in-children-with-attention-deficit-hyperactivity-disorder-a-focus-on-subgenual-anterior-cingulate-cortex
#19
Chenyang Zhan, Yuhong Liu, Kai Wu, Yu Gao, Xiaobo Li
Attention-deficit/hyperactivity disorder (ADHD), characterized by developmentally inappropriate inattention, hyperactivity/impulsivity, or a combination of both, is a major public health problem. Neuroimaging studies have revealed associations of these cognitive impairments with structural and functional deficits all over the brain. Existing findings are not fully consistent because of the heterogeneity of study samples and diversity of research techniques. In this study, we propose to utilize a multimodal magnetic resonance imaging (MRI) approach to study the structural and functional brain networks in children with ADHD-combined type (ADHD-C) with a focus on the subgenual anterior cingulate cortex (sgACC)...
March 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28168521/does-apolipoprotein-a1-predict-microstructural-changes-in-subgenual-cingulum-in-early-parkinson
#20
Farzaneh Rahmani, Mohammad Hadi Aarabi
Higher plasma cholesterol levels are associated with lower Parkinson's disease (PD) risk. Apolipoprotein A-1 (ApoA-1) is a surface marker of brain HDL-like particles associated with the time of PD onset. Clinical correlates of serum Apolipoprotein A1 levels with structural brain connectivity in PD-related disorders remains unclear. Here, we applied a novel diffusion-weighted imaging approach [Diffusion Magnetic Resonance Imaging (MRI) Connectometry] to explore the association between ApoA-1 and structural brain connectivity in PD...
February 6, 2017: Journal of Neurology
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