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https://www.readbyqxmd.com/read/29240880/assessment-of-histological-remission-in-ulcerative-colitis-discrepancies-between-daily-practice-and-expert-opinion
#1
Tessa E H Römkens, Pim Kranenburg, Arjan van Tilburg, Carolien Bronkhorst, Iris D Nagtegaal, Joost P H Drenth, Frank Hoentjen
Background and aims: Histological remission (HR) is a potential treatment target in ulcerative colitis (UC). Limited 'real world ' data is available on reliability of histological scoring when assessing minimal histological inflammation. The aim of our study was to investigate the reliability of UC histological scores in colonic biopsies showing mucosal healing (MH) and limited histological inflammation, and to compare the 'daily practice' histological assessment with expert reviews by gastrointestinal (GI)-pathologists...
December 12, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29240533/investigation-of-perceptual-motor-behavior-across-the-expert-athlete-to-disabled-patient-skill-continuum-can-advance-theory-and-practical-application
#2
Sean Müller, Ann-Maree Vallence, Carolee Winstein
A framework is presented of how theoretical predictions can be tested across the expert athlete to disabled patient skill continuum. Common-coding theory is used as the exemplar to discuss sensory and motor system contributions to perceptual-motor behavior. Behavioral and neural studies investigating expert athletes and patients recovering from cerebral stroke are reviewed. They provide evidence of bi-directional contributions of visual and motor systems to perceptual-motor behavior. Majority of this research is focused on perceptual-motor performance or learning, with less on transfer...
December 14, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29240457/urinary-peptidomics-in-kidney-disease-and-drug-research
#3
Magdalena Krochmal, Joost P Schanstra, Harald Mischak
Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases...
December 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29240456/trainees-perceptions-of-feedback-validity-evidence-for-two-feedme-feedback-in-medical-education-instruments
#4
Robert Bing-You, Saradha Ramesh, Victoria Hayes, Kalli Varaklis, Denham Ward, Maria Blanco
Construct: Medical educators consider feedback a core component of the educational process. Effective feedback allows learners to acquire new skills, knowledge, and attitudes. Learners' perceptions of feedback are an important aspect to assess with valid methods in order to improve the feedback skills of educators and the feedback culture. BACKGROUND: Although guidelines for delivering effective feedback have existed for several decades, medical students and residents often indicate that they receive little feedback...
December 14, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29239850/small-bowel-capsule-endoscopy-may-we-delegate-it-to-nurses
#5
Johann Dreanic, Maximilien Barret, Marion Dhooge, Marianne Gaudric, Sarah Leblanc, Vered Abitbol, Frederic Prat, Stanislas Chaussade, Romain Coriat
AIM: Small bowel capsule endoscopy (CE) is a non-invasive and validated technique allowing the visualization of the small intestine mucosa. It generated more than 40,000 images per examination and induced a long median time of medical reading that may exceed 1 hour. In a transfer of skills' program, the CE reading might be transferred to nurses. We herein evaluate and present a feasibility study of the CE to nurses. METHODS: Nurses experienced in endoscopy were trained for small bowel CE reading, selection and interpretation of pathological images...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29239793/medical-societies-patient-education-initiatives-public-debate-and-marketing-of-unproven-stem-cell-interventions
#6
Daniel J Weiss, Leigh Turner, Aaron D Levine, Laertis Ikonomou
Businesses marketing unproven stem cell interventions proliferate within the U.S. and in the larger global marketplace. There have been global efforts by scientists, patient advocacy groups, bioethicists, and public policy experts to counteract the uncontrolled and premature commercialization of stem cell interventions. In this commentary, we posit that medical societies and associations of health care professionals have a particular responsibility to be an active partner in such efforts. We review the role medical societies can and should play in this area through patient advocacy and awareness initiatives...
November 24, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29239156/do-patients-require-escorts-or-carers-for-discharge-following-day-surgery-and-office-based-anesthesia-both-sides-of-the-debate-explored
#7
Keira P Mason, Christopher M Burkle
Over the past few years, there has been a rapid rise in office-based procedures, out of hospital and day surgery procedures, particularly as an effort to combat the escalating costs of hospital- based services. Coincident with this burgeoning demand for office based anesthesia, is the accompanying increased risk of anesthesia and sedation-related complications. In the 1990's and 2000's, the risk of mortality was higher for anesthetics and sedations performed outside of the operating theater setting. Although guidelines exist for ambulatory and office based anesthesia, they are being continuously reviewed and reconsidered...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29238478/exploring-the-challenges-of-the-iranian-parliament-about-passing-laws-for-resource-allocation-in-healthcare-a-qualitative-study
#8
Seyed Ramezan Mohsenpour, Mohammad Arab, Seyed Hasan Emami Razavi, Ali Akbari Sari
Background: Awareness about the process of law making and the factors that affect the legislative process have an important role in improving legislations that are approved by parliaments. Objective: This study aimed to explore and analyze the process of development and enactment of law in Iran's parliament, and factors that might affect the enactment of laws that are related to the allocation and distribution of health sector resources in Iran. Methods: In this case study, data were collected through review of literature and national documents, and experts' interviews...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29237652/evidence-based-recommendations-on-care-for-breast-cancer-survivors-for-primary-care-providers-a-review-of-evidence-based-breast-cancer-guidelines
#9
Inge Spronk, Joke C Korevaar, Francois G Schellevis, Tit Albreht, Jako S Burgers
OBJECTIVE: To review evidence-based (EB) recommendations on survivorship care for primary care providers (PCPs) in EB breast cancer guidelines. DESIGN AND SETTING: Guidelines were collected via experts and via literature database, guideline database and cancer agency websites searches. METHOD: EB guidelines in any language published between 2012 and 2017 were collected. EB recommendations on survivorship care relevant for PCPs were extracted and grouped into three categories (recurrence detection, long-term effects and recurrence prevention)...
December 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29237400/accuracy-of-acute-burns-diagnosis-made-using-smartphones-and-tablets-a-questionnaire-based-study-among-medical-experts
#10
Lisa Blom, Constance Boissin, Nikki Allorto, Lee Wallis, Marie Hasselberg, Lucie Laflamme
BACKGROUND: Remote assistance for burns by medical experts can support nurses and general physicians in emergency care with diagnostic and management advice. Previous studies indicate a high diagnostic accuracy based on images viewed on a computer screen, but whether image-based analysis by experts using handheld devices is accurate remains to be determined. METHOD: A review of patient data from eight emergency centres in the Western Cape, South Africa, revealed 10 typical cases of burns commonly seen in children and adults...
December 13, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29237337/key-interventions-and-quality-indicators-for-quality-improvement-of-stemi-care-a-rand-delphi-survey
#11
Daan Aeyels, Peter R Sinnaeve, Marc J Claeys, Sofie Gevaert, Danny Schoors, Walter Sermeus, Massimiliano Panella, Ellen Coeckelberghs, Luk Bruyneel, Kris Vanhaecht
OBJECTIVE: Identification, selection and validation of key interventions and quality indicators for improvement of in hospital quality of care for ST-elevated myocardial infarction (STEMI) patients. METHODS AND RESULTS: A structured literature review was followed by a RAND Delphi Survey. A purposively selected multidisciplinary expert panel of cardiologists, nurse managers and quality managers selected and validated key interventions and quality indicators prior for quality improvement for STEMI...
December 13, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29237331/autism-spectrum-disorder-consensus-guidelines-on-assessment-treatment-and-research-from-the-british-association-for-psychopharmacology
#12
Oliver D Howes, Maria Rogdaki, James L Findon, Robert H Wichers, Tony Charman, Bryan H King, Eva Loth, Gráinne M McAlonan, James T McCracken, Jeremy R Parr, Carol Povey, Paramala Santosh, Simon Wallace, Emily Simonoff, Declan G Murphy
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29237296/pharmacokinetic-evaluation-of-besifovir-for-the-treatment-of-hbv-infection
#13
Lung-Yi Mak, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
Besifovir (LB80380) is a relatively new oral acyclic nucleotide phosphonate. We reviewed the pharmacokinetic characteristics of LB80380 and discussed its role in the treatment of chronic hepatitis B infection. Areas covered: LB80380 is a prodrug of LB80331 and LB8031. It is rapidly absorbed when taken orally. Escalating doses of besifovir produce linear increase of the plasma concentration. Doses above 60mg are effective for inhibiting HBV in human. Using 60mg as an example, the maximal concentration of LB80331 in plasma is 397 ng/mL...
December 13, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29237099/calcium-channel-blockers-for-primary-and-secondary-raynaud-s-phenomenon
#14
REVIEW
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29236837/construction-and-validation-of-a-nursing-care-protocol-in-anesthesia
#15
Cassiane de Santana Lemos, Vanessa de Brito Poveda, Aparecida de Cassia Giane Peniche
OBJECTIVE: To construct and validate a nursing care protocol in anesthesia. METHOD: methodological study of face and content validation, judging clarity, relevance, pertinence and comprehensiveness of a care protocol, elaborated from the integrative review of previous literature and based on the conceptual model of assistance perioperative nursing of Castellanos and Jouclas. The protocol was evaluated by five anesthesiologists and nurses from the surgical center...
December 11, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29236593/role-of-genetic-testing-for-inherited-prostate-cancer-risk-philadelphia-prostate-cancer-consensus-conference-2017
#16
Veda N Giri, Karen E Knudsen, William K Kelly, Wassim Abida, Gerald L Andriole, Chris H Bangma, Justin E Bekelman, Mitchell C Benson, Amie Blanco, Arthur Burnett, William J Catalona, Kathleen A Cooney, Matthew Cooperberg, David E Crawford, Robert B Den, Adam P Dicker, Scott Eggener, Neil Fleshner, Matthew L Freedman, Freddie C Hamdy, Jean Hoffman-Censits, Mark D Hurwitz, Colette Hyatt, William B Isaacs, Christopher J Kane, Philip Kantoff, R Jeffrey Karnes, Lawrence I Karsh, Eric A Klein, Daniel W Lin, Kevin R Loughlin, Grace Lu-Yao, S Bruce Malkowicz, Mark J Mann, James R Mark, Peter A McCue, Martin M Miner, Todd Morgan, Judd W Moul, Ronald E Myers, Sarah M Nielsen, Elias Obeid, Christian P Pavlovich, Stephen C Peiper, David F Penson, Daniel Petrylak, Curtis A Pettaway, Robert Pilarski, Peter A Pinto, Wendy Poage, Ganesh V Raj, Timothy R Rebbeck, Mark E Robson, Matt T Rosenberg, Howard Sandler, Oliver Sartor, Edward Schaeffer, Gordon F Schwartz, Mark S Shahin, Neal D Shore, Brian Shuch, Howard R Soule, Scott A Tomlins, Edouard J Trabulsi, Robert Uzzo, Donald J Vander Griend, Patrick C Walsh, Carol J Weil, Richard Wender, Leonard G Gomella
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing...
December 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29235882/early-warning-systems-for-the-management-of-chronic-heart-failure-a-systematic-literature-review-of-cost-effectiveness-models
#17
Fernando Albuquerque de Almeida, Maiwenn Al, Ron Koymans, Kadir Caliskan, Ankie Kerstens, Johan L Severens
Introduction Describing the general and methodological characteristics of decision-analytical models used in the economic evaluation of early warning systems for the management of chronic heart failure patients and performing a quality assessment of their methodological characteristics is expected to provide concise and useful insight to inform the future development of decision-analytical models in the field of heart failure management. Areas covered The literature on decision-analytical models for the economic evaluation of early warning systems for the management of chronic heart failure patients was systematically reviewed...
December 13, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29235405/mapping-the-balint-groups-to-the-accreditation-council-for-graduate-medical-education-family-medicine-competencies
#18
Albert Lichtenstein, Jumana Antoun, Chris Rule, Katherine Knowlton, Jeffrey Sternlieb
Introduction Balint group discussions provide learning opportunities for many of the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. The current literature is mixed concerning the effect of Balint groups on communication skills and professionalism. Aim To map the content of the Balint discussion to the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. METHODOLOGY: A group who were both experts in Balint and members of the clinical competency committee of residency programs rated narratives that summarized Balint group discussions...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235402/biofilm-related-disease
#19
Jose Luis Del Pozo
Biofilm formation represents a protected mode of growth that renders bacterial cells less susceptible to antimicrobials and to killing by host immune effector mechanisms and so enables the pathogens to survive in hostile environments and also to disperse and colonize new niches. Biofilm disease includes device-related infections, chronic infections in the absence of a foreign body, and even malfunction of medical devices. Areas covered: This review puts forward a new medical entity that represents a major public health issue, which we have named "biofilm-related disease"...
December 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29235400/role-of-bevacizumab-in-the-management-of-the-patient-with-malignant-pleural-effusion-more-questions-than-answers
#20
Ralph Llewel Sabang, Deepthi Gandhiraj, Michael Fanucchi, Oleg Epelbaum
Malignant pleural effusion (MPE) is a feature of metastatic cancer that is associated with significant morbidity and healthcare costs. The typical current management of MPE involves the combination of systemic chemotherapy and mechanical intervention in the pleural space. Vascular endothelial growth factor (VEGF), an extremely potent inducer of vascular permeability, has been shown to mediate fluid formation in pleural malignancy. Therefore, bevacizumab, an inhibitor of VEGF activity, offers theoretical promise as a means of abolishing fluid formation in MPE...
December 13, 2017: Expert Review of Respiratory Medicine
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