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https://www.readbyqxmd.com/read/29161498/selective-isolation-of-myosin-subfragment-1-with-a-dna-polyoxovanadate-bioconjugate
#1
Qing Chen, Xue Hu, Dan-Dan Zhang, Xuwei Chen, Jian-Hua Wang
The bioconjugation of a polyoxometalate (POMs), i.e., dodecavanadate (V12O32), to DNA strands produces a functional labeled DNA primer, V12O32-DNA. The grafting of DNA primer onto streptavidin-coated magnetic nanoparticles (SVM) obtains a novel composite, V12O32-DNA@SVM. The high binding-affinity of V12O32 with the ATP binding site in myosin subfragment-1 (S1) facilitates favorable adsorption of myosin, with an efficiency of 99.4% when processing 0.1 mL myosin solution (100 μg/mL) using 0.1 mg composite. Myosin adsorption fits Langmuir model, corresponding to a theoretical adsorption capacity of 613...
November 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29161402/fit-for-surgery-perspectives-on-preoperative-exercise-testing-and-training
#2
K Richardson, D Z H Levett, S Jack, M P W Grocott
There is a consistent relationship between physical activity, physical fitness, and health across almost all clinical contexts, including the perioperative setting. Physiological measurements obtained during physical exercise may be used to infer the risk of adverse outcome after major surgery. In particular, data obtained from perioperative cardiopulmonary exercise testing have an expanding role in perioperative care. Such information may be used to inform a variety of changes in clinical practice, including interventions that may reduce the risk of perioperative adverse events...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161399/global-lessons-developing-military-trauma-care-and-lessons-for-civilian-practice
#3
T Woolley, J A Round, M Ingram
The wars in Iraq and Afghanistan have helped to shape the modern Defence Medical Services. Many lessons were learnt including the need for rapid haemorrhage control, senior decision-making and the evolution of deployed transfusion support. These changes were implemented simultaneously with a coherent, end-to-end medical plan from point of wounding through to rehabilitation. Implementation of the medical plan is harmonious with the NHS trauma pathway, and is key to ensuring effective delivery. Military anaesthetists have a long pre-deployment training pathway starting with a Certificate of Completion of Training (CCT) in anaesthesia and/or critical care, and with an emphasis on military skills related to their specific role...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161397/abdominal-aortic-aneurysm-repair-in-the-united-kingdom-an-exemplar-for-the-role-of-anaesthetists-in-perioperative-medicine
#4
S J Howell
The past two decades have seen an increasing recognition that the delivery of safe surgery with low complication rates and good long-term outcomes is a team endeavour embracing the whole patient care pathway. The key role of the anaesthetist in managing the patient through the surgical process is widely understood and has driven the emergence of perioperative medicine. In parallel with these developments there has been a sea change in the organisation of the care of patients presenting for elective abdominal aortic aneurysm (AAA) repair...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29160980/antegrade-vs-retrograde-cannulation-does-the-evidence-support-a-practice-change
#5
Lynda K Ball
No abstract text is available yet for this article.
September 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29160924/accelerated-untargeted-metabolomics-analysis-of-cutaneous-t-cell-lymphoma-reveal-metabolic-shifts-in-plasma-and-tumor-adjacent-skins-of-xenograft-mice
#6
Yunchen Le, Xiaoyan Shen, Hongyan Kang, Qizheng Wang, Kejia Li, Jie Zheng, Yunqiu Yu
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of skin-homing T-cell neoplasms. Clinical management is stage based but diagnosis and prognosis could be extremely challenging. The presented study aims to explore the metabolic profiling of CTCL by an accelerated untargeted metabolomics data analysis tool "mummichog" to facilitate the discoveries of potential biomarkers for clinical early-stage diagnosis, prognosis and treatments in CTCL. Ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) based untargeted metabolomics were conducted on the skin and plasma of CTCL mice...
November 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29160733/potential-impact-of-inorganic-nanoparticles-on-macronutrient-digestion-titanium-dioxide-nanoparticles-slightly-reduce-lipid-digestion-under-simulated-gastrointestinal-conditions
#7
Qian Li, Ti Li, Chengmei Liu, Glen DeLoid, Georgios Pyrgiotakis, Philip Demokritou, Ruojie Zhang, Hang Xiao, David Julian McClements
Titanium dioxide (TiO2) particles are used in some food products to alter their optical properties, such as whiteness or brightness. These additives typically contain a population of TiO2 nanoparticles (d < 100 nm), which has led to concern about their potential toxicity. The objective of this study was to examine the impact of TiO2 particles on the gastrointestinal fate of oil-in-water emulsions using a simulated gastrointestinal tract (GIT) that includes mouth, stomach, and small intestine phases...
November 21, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29160397/mechanical-preparation-showed-superior-shaping-ability-than-manual-technique-in-primary-molars-a-micro-computed-tomography-study
#8
Lídia Regina da Costa Hidalgo, Léa Assed Bezerra da Silva, Graziela Bianchi Leoni, Jardel Francisco Mazzi-Chaves, Emily Eduardo da Silva Carvalho, Alberto Consolaro, Manoel Damião Sousa-Neto
The aim of the study was to evaluate canal preparation in primary molars with hand files, ProTaper Next and Self-Adjusting File (SAF) by 2D and 3D micro-computed tomography (micro-CT) analysis. Canals of 24 primary molars were prepared with hand files (HF), ProTaper Next (PTN) and SAF (n=8/group). The teeth were scanned before and after root canal preparation and the pre- and postoperative micro-CT images were reconstructed. Changes in 2D (area, perimeter, roundness, minor and major diameter) and 3D [volume, surface area, structure model index (SMI)] morphological parameters, as well as canal transportation and lateral perforations were evaluated (Kruskal-Wallis and ANOVA; a=0...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160083/mechanisms-and-applications-of-redox-sensitive-gfp-based-h2o2-probes
#9
Leticia Prates Roma, Marcel Deponte, Jan Riemer, Bruce Morgan
SIGNIFICANCE: Genetically encoded H2O2 sensors, based upon fusions between thiol peroxidases and redox-sensitive green fluorescent protein 2 (roGFP2) have dramatically broadened the available 'toolbox' for monitoring cellular H2O2 changes. Recent advances: Recently developed peroxiredoxin-based probes such as roGFP2-Tsa2∆CR offer considerably improved H2O2-sensitivity compared to previously available genetically encoded sensors and now permit dynamic, real-time, monitoring of changes in endogenous H2O2 levels...
November 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29160024/a-conceptual-framework-for-understanding-the-perspectives-on-the-causes-of-the-science-practice-gap-in-ecology-and-conservation
#10
Diana Bertuol-Garcia, Carla Morsello, Charbel N El-Hani, Renata Pardini
Applying scientific knowledge to confront societal challenges is a difficult task, an issue known as the science-practice gap. In Ecology and Conservation, scientific evidence has been seldom used directly to support decision-making, despite calls for an increasing role of ecological science in developing solutions for a sustainable future. To date, multiple causes of the science-practice gap and diverse approaches to link science and practice in Ecology and Conservation have been proposed. To foster a transparent debate and broaden our understanding of the difficulties of using scientific knowledge, we reviewed the perceived causes of the science-practice gap, aiming to: (i) identify the perspectives of ecologists and conservation scientists on this problem, (ii) evaluate the predominance of these perspectives over time and across journals, and (iii) assess them in light of disciplines studying the role of science in decision-making...
November 20, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29159978/ahns-series-do-you-know-your-guidelines-guideline-recommendations-for-head-and-neck-cancer-of-unknown-primary-site
#11
Antoine Eskander, Tamer Ghanem, Amit Agrawal
This article reviews the clinical practice guidelines for head and neck oncology focusing on the management of head and neck cancers of unknown primary (CUP). The primary purpose of this series is to raise awareness of the current guidelines in head and neck oncology by reviewing the recommendations and the evidence supporting such recommendations, particularly those published by the National Comprehensive Cancer Network (NCCN). We review the importance of a thorough history and physical examination, the impact of the American Joint Committee on Cancer (AJCC) eighth edition changes and the importance of immunohistochemistry, the timing and type of imaging, the role of panendoscopy and tonsillectomy (palatine and lingual), and the role of surgery, radiation, and chemotherapy in the primary management of these tumors...
November 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/29159583/the-association-between-artificial-sweeteners-and-obesity
#12
REVIEW
Michelle Pearlman, Jon Obert, Lisa Casey
PURPOSE OF REVIEW: The purpose of this paper is to review the epidemiology of obesity and the evolution of artificial sweeteners; to examine the latest research on the effects of artificial sweeteners on the host microbiome, the gut-brain axis, glucose homeostasis, and energy consumption; and to discuss how all of these changes ultimately contribute to obesity. RECENT FINDINGS: Although artificial sweeteners were developed as a sugar substitute to help reduce insulin resistance and obesity, data in both animal models and humans suggest that the effects of artificial sweeteners may contribute to metabolic syndrome and the obesity epidemic...
November 21, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29158769/physicians-duty-to-recontact-and-update-genetic-advice
#13
Yvonne A Stevens, Grant D Senner, Gary E Marchant
This perspective addresses whether physicians have a duty to recontact former or current patients to update clinical advice based on newly discovered genomic information. Genetic information is unique compared with other medical data in that the underlying data do not appreciably change during the patients' lifetime, but the clinical significance of that information will continue to evolve. Based on relevant case law and guidelines, there is no general, established legal duty for physicians to affirmatively recontact former or current patients to update clinical advice based on newly discovered genetic information...
2017: Personalized Medicine
https://www.readbyqxmd.com/read/29158660/empowering-one-community-at-a-time-for-policy-system-and-environmental-changes-to-impact-obesity
#14
Katrina Betancourt, Andrea Ridgway, Joy Rockenbach, Sequoya Eady, Joanice Thompson, Lori Brand Bateman, Mona N Fouad, Yu-Mei M Schoenberger
Objective: This article describes Mayors Mentoring Mayors (3M), an initiative of the Arkansas Coalition for Obesity Prevention (ArCOP), which expanded to five states to become the signature community initiative of the Mid-South Transdisciplinary Collaborative Center (Mid-South TCC) for Health Disparities Research. Methods: The 3M program is an extension of the Growing Healthy Communities (GHC) program, which sought to build capacity within communities to reduce obesity by implementing policy, system and environmental (PSE) changes that support healthy living...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29158624/plant-growth-under-water-salt-stress-ros-production-antioxidants-and-significance-of-added-potassium-under-such-conditions
#15
Mohammad Abass Ahanger, Nisha Singh Tomar, Megha Tittal, Surendra Argal, R M Agarwal
Plants are confronted with a variety of environmenmtal stresses resulting in enhanced production of ROS. Plants require a threshold level of ROS for vital functions and any change in their concentration alters the entire physiology of plant. Delicate balance of ROS is maintained by an efficient functioning of intriguing indigenous defence system called antioxidant system comprising enzymatic and non enzymatic components. Down regulation of antioxidant system leads to ROS induced oxidative stress causing damage to important cellular structures and hence anomalies in metabolism...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29158427/do-emotions-related-to-alcohol-consumption-differ-by-alcohol-type-an-international-cross-sectional-survey-of-emotions-associated-with-alcohol-consumption-and-influence-on-drink-choice-in-different-settings
#16
Kathryn Ashton, Mark A Bellis, Alisha R Davies, Karen Hughes, Adam Winstock
OBJECTIVES: To examine the emotions associated with drinking different types of alcohol, explore whether these emotions differ by sociodemographics and alcohol dependency and whether the emotions associated with different drink types influence people's choice of drinks in different settings. DESIGN: International cross-sectional opportunistic survey (Global Drug Survey) using an online anonymous questionnaire in 11 languages promoted through newspapers, magazines and social media from November 2015 to January 2016...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29158228/stigma-experienced-by-children-and-adolescents-with-obesity
#17
Stephen J Pont, Rebecca Puhl, Stephen R Cook, Wendelin Slusser
The stigmatization of people with obesity is widespread and causes harm. Weight stigma is often propagated and tolerated in society because of beliefs that stigma and shame will motivate people to lose weight. However, rather than motivating positive change, this stigma contributes to behaviors such as binge eating, social isolation, avoidance of health care services, decreased physical activity, and increased weight gain, which worsen obesity and create additional barriers to healthy behavior change. Furthermore, experiences of weight stigma also dramatically impair quality of life, especially for youth...
November 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29157645/law-based-arguments-and-messages-to-advocate-for-later-school-start-time-policies-in-the-united-states
#18
REVIEW
Clark J Lee, Dennis M Nolan, Steven W Lockley, Brent Pattison
The increasing scientific evidence that early school start times are harmful to the health and safety of teenagers has generated much recent debate about changing school start times policies for adolescent students. Although efforts to promote and implement such changes have proliferated in the United States in recent years, they have rarely been supported by law-based arguments and messages that leverage the existing legal infrastructure regulating public education and child welfare in the United States. Furthermore, the legal bases to support or resist such changes have not been explored in detail to date...
December 2017: Sleep Health
https://www.readbyqxmd.com/read/29157642/engaging-the-community-in-the-process-of-changing-school-start-times-experience-of-the-cherry-creek-school-district
#19
Lisa J Meltzer, Janise McNally, Amy E Plog, Scott A Siegfried
Despite growing evidence of the positive impact of later school start times on adolescent health and academic outcomes, relatively few districts have changed start times due to concerns about transportation, child care, and athletics/extracurricular activities. This paper provides a case study of the Cherry Creek School District's (CCSD) successful efforts to change start times. The CCSD is a diverse district with an enrollment of almost 55,000 students in suburban Denver. As part of CCSD's strategic plan, a multi-disciplinary task force was formed to examine the impact of start times on student achievement, and recommend a start time schedule driven by best practices on adolescent sleep patterns, balanced with family and community needs...
December 2017: Sleep Health
https://www.readbyqxmd.com/read/29157639/the-economic-implications-of-later-school-start-times-in-the-united-states
#20
Marco Hafner, Martin Stepanek, Wendy M Troxel
Numerous studies have shown that later school start times (SST) are associated with positive student outcomes, including improvements in academic performance, mental and physical health, and public safety. While the benefits of later SST are very well documented in the literature, in practice there is opposition against delaying SST. A major argument against later SST is the claim that delaying SST will result in significant additional costs for schools due to changes in bussing strategies. However, to date, there has only been one published study that has quantified the potential economic benefits of later SST in relation to potential costs...
December 2017: Sleep Health
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