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https://www.readbyqxmd.com/read/28522734/voluntary-control-of-epileptiform-spike-wave-discharges-in-awake-rats
#1
Jeremy A Taylor, Krista M Rodgers, Florencia M Bercum, Carmen J Booth, F Edward Dudek, Daniel S Barth
Genetically inherited absence epilepsy in humans is typically characterized by brief (seconds) spontaneous seizures, which involve spike-wave discharges (SWDs) in the EEG and interruption of consciousness and ongoing behavior. Genetic (inbred) models of this disorder in rats have been used to examine mechanisms, comorbidities and anti-absence drugs. SWDs have also been proposed as models of complex partial seizures (CPSs) following traumatic brain injury (post-traumatic epilepsy; PTE). However, the ictal characteristics of these rat models, including SWDs and associated immobility, are also prevalent in healthy outbred laboratory rats...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28522201/adsorption-of-p-nitrophenols-pnp-on-microalgal-biochar-analysis-of-high-adsorption-capacity-and-mechanism
#2
Heshan Zheng, Wanqian Guo, Shuo Li, Yidi Chen, Qinglian Wu, Xiaochi Feng, Renli Yin, Shih-Hsin Ho, Nanqi Ren, Jo-Shu Chang
Biochars derived from three microalgal strains (namely, Chlorella sp. Cha-01, Chlamydomonas sp. Tai-03 and Coelastrum sp. Pte-15) were evaluated for their capacity to adsorb p-nitrophenols (PNP) using raw microalgal biomass and powdered activated carbon (PAC) as the control. The results show that BC-Cha-01 (biochar from Chlorella sp. Cha-01) exhibited a high PNP adsorption capacity of 204.8mgg(-1), which is 250% and 140% higher than that of its raw biomass and PAC, respectively. The adsorption kinetics and equilibrium are well described with pseudo-second-order equation and Freundlich model, respectively...
May 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28522083/relationships-between-potentially-traumatic-events-sleep-disturbances-and-symptoms-of-ptsd-and-alcohol-use-disorder-in-a-young-adult-sample
#3
Mackenzie J Lind, Allison Baylor, Cassie M Overstreet, Sage E Hawn, Bruce D Rybarczyk, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: Traumatic events, particularly those that are interpersonal in nature, are associated with increased risk for co-occurring sequelae, including sleep disturbances, posttraumatic stress disorder (PTSD), and alcohol use disorder (AUD). However, the associations between these phenotypes have not been explored among college students. METHODS: We examined relationships between type of potentially traumatic event (PTE) exposure (pre-college) and sleep disturbances, as well as mediating effects of lifetime PTSD and AUD symptoms on these relationships, in a large undergraduate sample (N = 1599, 64...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28502408/combined-effect-of-low-back-muscle-fatigue-and-passive-tissue-elongation-on-the-flexion-relaxation-response
#4
Sangeun Jin, Gary A Mirka
Previous literature has documented the alterations in the flexion-relaxation response of the lumbar extensor musculature to passive tissue elongation (PTE) and muscle fatigue (MF). There is no study, however, that has explored this response as a function of the combined effect of both PTE and MF, which is often seen in occupational settings. Twelve participants performed three experimental protocols on three different days to achieve (1) PTE, (2) MF and (3) PTE&MF (combined). Trunk kinematics and muscle activities were monitored to assess the effects of these protocols on the peak lumbar flexion angle and the lumbar angle of the flexion-relaxation of the trunk extensor muscles...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28484717/recent-progress-in-research-on-the-pathogenesis-of-pulmonary-thromboembolism-an-old-story-with-new-perspectives
#5
REVIEW
Chao Yan, Xiaohua Wang, Hua Su, Kejing Ying
Pulmonary thromboembolism (PTE) is part of a larger clinicopathological entity, venous thromboembolism. It is also a complex, multifactorial disorder divided into four major disease processes including venous thrombosis, thrombus in transit, acute pulmonary embolism, and pulmonary circulation reconstruction. Even when treated, some patients develop chronic thromboembolic pulmonary hypertension. PTE is also a common fatal type of pulmonary vascular disease worldwide, but earlier studies primarily focused on the pathological changes in the blood component of the disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28481835/patients-perceived-treatment-effectiveness-in-dry-eye-disease
#6
Ahmad Kheirkhah, Alja Crnej, Ai Ren, Andrew Mullins, Vannarut Satitpitakul, Pedram Hamrah, Debra Schaumberg, Reza Dana
PURPOSE: Patients' perceptions of the effectiveness of a treatment, or perceived treatment effectiveness (PTE), play an important role in medicine. This study aimed to evaluate patients' PTE in dry eye disease (DED) and investigate factors contributing to these patients' perceptions. METHODS: This cross-sectional study included 66 patients with DED. At enrollment, all patients had comprehensive ophthalmic assessment. In addition, to evaluate the patient's PTE, they were asked to use a 10-point scale ranging from "strongly disagree (score 1)" to "strongly agree (score 10)" to score their views on whether their DED treatments had been effective...
May 3, 2017: Cornea
https://www.readbyqxmd.com/read/28480266/efficacy-and-safety-of-oritavancin-relative-to-vancomycin-for-patients-with-acute-bacterial-skin-and-skin-structure-infections-absssi-in-the-outpatient-setting-results-from-the-solo-clinical-trials
#7
Thomas P Lodise, Mark Redell, Shannon O Armstrong, Katherine A Sulham, G Ralph Corey
BACKGROUND: The objective of this analysis was to evaluate the efficacy and safety of oritavancin compared with vancomycin for patients with acute bacterial skin and skin structure infections (ABSSSIs) who received treatment in the outpatient setting in the Phase 3 SOLO clinical trials. METHODS: SOLO I and SOLO II were 2 identically designed comparative, multicenter, double-blind, randomized studies to evaluate the efficacy and safety of a single 1200-mg dose of intravenous (IV) oritavancin versus 7-10 days of twice-daily IV vancomycin for the treatment of ABSSSI...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479668/sex-differences-in-the-contribution-of-respiratory-sinus-arrhythmia-and-trauma-to-children-s-psychopathology
#8
Sarah A O Gray, Katherine Theall, Rebecca Lipschutz, Stacy Drury
Respiratory sinus arrhythmia (RSA), a marker of parasympathetic activity, has been shown to moderate the relation between adversity and child behavioral outcomes; however, this work has been conducted in primarily Caucasian samples and limited in focus to family-level adversity. The current analysis extends the previous literature to examine the co-contribution of exposure to potentially traumatic events (PTEs), baseline RSA, and RSA withdrawal to internalizing and externalizing behavior in a sample of primarily African American youth (n = 92) recruited using neighborhood mapping techniques from communities high in epidemiological indicators of adversity...
March 2017: Journal of Psychopathology and Behavioral Assessment
https://www.readbyqxmd.com/read/28476246/update-on-the-risk-stratification-of-acute-symptomatic-pulmonary-thromboembolism
#9
A Maestre Peiró, A Gonzálvez Gasch, M Monreal Bosch
Early mortality in patients with pulmonary thromboembolism (PTE) varies from 2% in normotensive patients to 30% in patients with cardiogenic shock. The current risk stratification for symptomatic PTE includes 4 patient groups, and the recommended therapeutic strategies are based on this stratification. Patients who have haemodynamic instability are considered at high risk. Fibrinolytic treatment is recommended for these patients. In normotensive patients, risk stratification helps differentiate between those of low risk, intermediate-low risk and intermediate-high risk...
May 2, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28474982/posttraumatic-epilepsy-long-term-follow-up-of-children-with-mild-traumatic-brain-injury
#10
Amit Keret, Odeya Bennett-Back, Guy Rosenthal, Tal Gilboa, Moatasim Shweiki, Yigal Shoshan, Mony Benifla
OBJECTIVE Posttraumatic epilepsy (PTE) is a known complication of traumatic brain injury (TBI). The true incidence of PTE in children is still uncertain, because most research has been based primarily on adults. This study aimed to determine the true incidence of PTE in a pediatric population with mild TBI (MTBI) and to identify risk factors for the development of epileptic events. METHODS Data were collected from electronic medical records of children 0-17 years of age, who were admitted to a single medical center between 2007 and 2009 with a diagnosis of MTBI...
May 5, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28462553/pyomyositis-complicated-by-deep-venous-thrombosis-a-unique-case-of-reverse-lemierre-s-syndrome
#11
Uthara Elsa Mathew, Animesh Ray, Manish Soneja, Surabhi Vyas, Kjdb Sanker, Neeraj Nischal, Pankaj Jorwal, S K Sharma
We report a case of a young individual who presented with fever and swelling of right upper and lower limbs for 3 weeks. Subsequently he developed shortness of breath and decreased urine output and had to be mechanically ventilated. Ultrasound screening of the lower limb had shown deep venous thrombosis (DVT) and thus the diagnosis of pulmonary thromboembolism (PTE) seemed probable. However the workup for PTE was negative and patient's fever continued and his condition deteriorated. Evaluation for an infective locus led to the diagnosis of pyomyositis and DVT appeared to have developed secondary to the muscle inflammation as a part of Reverse Lemierre's syndrome...
March 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28460762/acute-pulmonary-thromboembolism-epidemiology-predictors-and-long-term-outcome-a-single-center-experience
#12
U M Nagamalesh, V S Prakash, K C Karthik Naidu, S Sarthak, Anupama V Hegde, T Abhinay
INTRODUCTION: Acute pulmonary thromboembolism (PTE) is a life-threatening disease. Mortality in PTE still remains very high in spite of progress in diagnostic tools. Mortality rate is about 30% in patients with unrecognized acute PTE. METHODS: It is a single center observational study of 31 consecutive patients who were hospitalized in the Department of Cardiology at MS Ramaiah Memorial hospital between January 1, 2010 and June 2015. All the patients confirmed with diagnosis of acute PTE by CT scan (either HRCT or CTPA) were included in the study...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28459578/review-of-design-of-precursors-for-sustainable-chemistry-design-of-precursors-for-sustainable-chemistry-by-karl-m-kadish-university-of-houston-usa-kevin-m-smith-louisiana-state-university-usa-and-roger-guilard-university-of-bourgogne-france-world-scientific
#13
https://www.readbyqxmd.com/read/28456171/on-the-role-of-the-entorhinal-cortex-in-the-effective-connectivity-of-the-hippocampal-formation
#14
Víctor J López-Madrona, Fernanda S Matias, Ernesto Pereda, Santiago Canals, Claudio R Mirasso
Inferring effective connectivity from neurophysiological data is a challenging task. In particular, only a finite (and usually small) number of sites are simultaneously recorded, while the response of one of these sites can be influenced by other sites that are not being recorded. In the hippocampal formation, for instance, the connections between areas CA1-CA3, the dentate gyrus (DG), and the entorhinal cortex (EC) are well established. However, little is known about the relations within the EC layers, which might strongly affect the resulting effective connectivity estimations...
April 2017: Chaos
https://www.readbyqxmd.com/read/28453701/an-exploratory-analysis-of-alkaline-phosphatase-lactate-dehydrogenase-and-prostate-specific-antigen-dynamics-in-the-phase-3-alsympca-trial-with-radium-223
#15
O Sartor, R E Coleman, S Nilsson, D Heinrich, S I Helle, J M O'Sullivan, N J Vogelzang, Ø Bruland, S Kobina, S Wilhelm, L Xu, M Shan, M W Kattan, C Parker
Background: Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods: The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of baseline variables was assessed using Cox models. Percentage changes in biomarker levels from baseline were evaluated during the trial period; changes from baseline to week 12 were evaluated for association with OS and surrogacy...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28449365/duty-related-trauma-exposure-and-posttraumatic-stress-symptoms-in-professional-firefighters
#16
Junghyun H Lee, Dayoung Lee, Jiae Kim, Kyoungsun Jeon, Minyoung Sim
Firefighters commonly encounter traumatic events during duty hours. The purpose of this study was to investigate the characteristics of duty-related trauma as risk factors for posttraumatic stress disorder in professional firefighters. A sample of 212 firefighters participated in the study and completed self-reported questionnaires. Potentially traumatic events (PTE) were assessed using a list of 17 traumatic event types. The posttraumatic stress symptoms (PTSS) were measured by the Impact of Event Scale-Revised (Lim et al...
April 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28428470/effects-of-valsalva-maneuver-by-different-breath-holding-techniques-to-detect-pulmonary-thromboembolism-in-a-contrast-enhanced-computed-tomography-examination
#17
Chiaki Suzuki, Kenji Fujisaki, Yuusuke Atsumi, Miki Takemura, Kouichi Mizuno, Takeki Nagamine, Tomoyasu Amano, Hideo Yamamoto, Mamoru Takahashi
The purpose of this study is to measure the hemodynamics on the effect of Valsalva maneuver aiming at pulmonary thromboembolism (PTE) using 2-dimensional (2D) phase contrast imaging of magnetic resonance image (MRI), Philips Ingenia 3.0-tesla (T). The maximal inspiration reduced the blood flow rate in various degrees at all measurement positions, superior vena cava (SVC), inferior vena cava (IVC), pulmonary artery (PA), ascending aorta (AA), and descending aorta (DA). This result suggests that the contrast effect in the PA might become weak during general PA phase to give a substantial influence of Valsalva maneuver in the condition after maximum inspiration...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28421553/microwave-ablation-of-malignant-renal-tumours-intermediate-term-results-and-usefulness-of-renal-and-mrenal-scores-for-predicting-outcomes-and-complications
#18
Anna Maria Ierardi, Alessio Puliti, Salvatore Alessio Angileri, Mario Petrillo, Ejona Duka, Chiara Floridi, Michela Lecchi, Gianpaolo Carrafiello
The aim of this study was to evaluate intermediate-term results after microwave ablation (MWA) of renal tumours and determine the association of RENAL and modified RENAL (mRENAL) scores with oncological outcomes and complications. In May 2008-September 2014, 58 patients affected by early-stage RCC (renal cell carcinoma; T1a or T1b) were judged unsuitable for surgery and treated with percutaneous MWA. Follow-up was performed with contrast-enhanced computed tomography at 1, 3, 6, 12 and 24 months after the procedure...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28406625/large-positive-thermal-expansion-and-small-band-gap-in-double-reo3-type-compound-nasbf6
#19
C Yang, B Y Qu, S S Pan, L Zhang, R R Zhang, P Tong, R C Xiao, J C Lin, X G Guo, K Zhang, H Y Tong, W J Lu, Y Wu, S Lin, W H Song, Y P Sun
Double-ReO3-type structure compound NaSbF6 undergoes a low-temperature rhombohedral to high-temperature cubic phase between 303 and 323 K, as revealed by temperature-dependent X-ray diffractions. Although many double-ReO3-type fluorides exhibit either low thermal expansion or negative thermal expansion (NTE), NaSbF6 exhibits positive thermal expansion (PTE) with a large volumetric coefficient of thermal expansion, αv = 62 ppm/K, in its cubic phase. Raman spectroscopy reveals that the low-frequency transverse vibration of fluorine atoms is stiffened in NaSbF6, compared with the typical NTE compound CaZrF6 with the same structure...
April 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28403474/smoking-in-pregnancy-and-fetal-growth-the-case-for-more-intensive-assessment
#20
Shannon Shisler, Rina D Eiden, Danielle S Molnar, Pamela Schuetze, Marilyn Huestis, Gregory Homish
Introduction: Many studies on prenatal tobacco exposure (PTE) effects have relied on single item retrospective measures of PTE. However, it is unclear how these single item measures may relate to more intensive maternal self-reports and to biological markers of maternal use and/or fetal exposure. It is also unclear whether these measures may be more valid predictors of fetal growth (gestational age, birthweight, head circumference, and birth length). Methods: Data were obtained from 258 women during their pregnancy...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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