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Yizi Xia, Ying Chen, Luming Tang, Zheng Wang, Yu Zheng
Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti-apoptotic and anti-inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment...
April 2018: Experimental and Therapeutic Medicine
Youngbeom Seo, Dong Gyu Kim, Jin Wook Kim, Jung Ho Han, Hyun-Tai Chung, Sun-Ha Paek
BACKGROUND: Gamma knife radiosurgery (GKRS) is recognized as an important treatment modality for meningioma. OBJECTIVE: To analyze the long-term outcomes in meningioma patients treated with GKRS to determine the risk factors related to treatment failure and peritumoral edema (PTE) development. METHODS: Between 1998 and 2010, 770 consecutive patients were treated with GKRS for intracranial meningioma. After the exclusion of patients with follow-up periods of less than 5 yr and those with neurofibromatosis, multiple meningiomas, nonbenign meningioma, or radiotherapy, a total of 424 patients were enrolled in this study...
March 12, 2018: Neurosurgery
Andrew N Bigley, Tamari Narindoshvili, Dao Feng Xiang, Frank M Raushel
The phosphotriesterase from Sphingobium sp. TCM1 (Sb-PTE) is notable for its ability to hydrolyze organophosphates that are not substrates for other enzymes. In an attempt to determine the catalytic properties of Sb-PTE for hydrolysis of chiral phosphotriesters we discovered that multiple phosphodiester products are formed from a single substrate. For example, Sb-PTE catalyzes the hydrolysis of the (RP)-enantiomer of methyl cyclohexyl p-nitrophenyl phosphate with exclusive formation of methyl cyclohexyl phosphate...
March 7, 2018: Biochemistry
John A Hondred, Joyce Breger, Nathan Alves, Scott A Trammell, Scott A Walper, Igor L Medintz, Jonathan C Claussen
Solution phase printing of graphene-based electrodes has recently become an attractive low-cost, scalable manufacturing technique to create in-field electrochemical biosensors. Here we report a graphene-based electrode developed via Inkjet Maskless Lithography (IML) for the direct and rapid monitoring of triple-O linked phosphonate organophosphates (OPs); these constitute the active compounds found in chemical warfare agents and pesticides that exhibit acute toxicity as well as long-term pollution to soils and waterways...
March 5, 2018: ACS Applied Materials & Interfaces
Songul Ozyurt, Savas Ozsu, Muge Erbay, Funda Oztuna, Aziz Gumus, Unal Sahin
INTRODUCTION: Syncope is infrequent in pulmonary thromboembolism (PTE) yet might be indicative of haemodynamic instability. The prognostic role of syncope in PTE has not been well documented. OBJECTIVES: In this study, the association between risk classification of the European Society of Cardiology and syncope was investigated in the normotensive PTE patients. METHODS: We retrospectively screened electronic medical records of patients who were admitted in two tertiary care hospital and diagnosis of PTE with computed tomography pulmonary angiography...
March 2, 2018: Clinical Respiratory Journal
Sunil Pandey, Krishna Hari Sharma, Amit Kumar Sharma, Yowan Nerthigan, Da-Ren Hang, Hui-Fen Wu
The present study deals with photothermal therapy of solid tumors using different forms oxygen deficient sub-stoichiometric two-dimensional (2D) molybdenum oxide nanoflakes (α-MoO3-x). Upon exfoliation of molybdenum oxide power using fine gridding followed by ultrasonication, bluish green molybdenum oxide (BG α-MoO3) was obtained. The oxygen vacancies in BG was generated by irradiating it using intense xenon lamp (600-900W, 200-1500nm) for 3-5 hours. Irradiating the BG for 3 and 5 hours, deep blue (B) and olive green (G) oxygen deficient nanoflakes were obtained respectively...
March 1, 2018: Chemistry: a European Journal
Daniel Mandell, Raymond Planinsic, Fernando Melean, Christopher Hughes, Amit D Tevar, Abhinav Humar, Benjamin J Cassidy, Richard Simmons, Andre Dewolf, Tetsuro Sakai
Tissue plasminogen activator (tPA) has been reported to treat intraoperative pulmonary thromboembolism (PTE) during liver transplantation (LT). However, tPA administration is often delayed due to fear of uncontrolled bleeding and storage in a refrigerator outside of operating rooms. Various dosages of tPA were used. We hypothesize that a policy of tPA storage and low dosage use improves patient outcomes. At a transplantation center, a multidisciplinary committee has implemented a tPA policy since April 2014, which includes the following: (1) timely administering of low-dose tPA (0...
February 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
Michael George Zaki Ghali, Jesse A Taylor, Mary Mallon, Patrick Gerety, Paul Shea, Sharon Weinberger, Jacqueline Urbine, Deepti Raybagkar
A 12-year-old boy presenting with chest pain and dyspnea was found to have bilateral pulmonary thromboembolism (PTE) secondary to left popliteal venous aneurysm (PVA) with thrombus. He improved with thrombolytics, developed recurrent PTE, then underwent surgical repair of his PVA. The pathophysiology, diagnosis, and management of PVA are discussed.
January 1, 2018: Vascular and Endovascular Surgery
Fernando Ruiz-Jasbon, Kristina Ticehurst, Jukka Ahonen, Jonny Norrby, Marie-Lois Ivarsson
Background and Objectives: The role of long-term degradable implants in reducing the risk of chronic postoperative pain after inguinal hernia repair is still unclear. A pilot study using a synthetic long-term resorbable mesh in Lichtenstein repair showed good results regarding pain and discomfort in patients with indirect inguinal hernia (IH) without recurrences, but higher recurrence rate in patients with direct inguinal hernia (DH). The purpose of this study was to assess the incidence of pain and early recurrence in patients with LIH surgically treated with the TEP technique using a long-term degradable mesh...
January 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Alexys G F Boim, Sónia M Rodrigues, Sabrina N Dos Santos-Araújo, Eduarda Pereira, Luís R F Alleoni
The anthropogenic input of potentially toxic elements (PTEs) from industry, agrochemicals, etc., into the environment are of great concern. Models derived from pedotransfer functions can provide estimates of the levels of PTEs based on soil attributes. Based on the importance of these models in studies in contaminated areas, we assessed the concentrations of the reactive contents of Ba, Cu, Cr, Ni, Pb, and Zn in soils cultivated with vegetable crops in the state of São Paulo, Brazil. We also evaluated the influence of chemical and physical soil attributes on their reactivity and availability...
February 21, 2018: Environmental Science and Pollution Research International
Sheila Adriana Mendoza-Mojica, Octavio Márquez-Mendoza, Marcela Veytia-López, Luciana Esther Ramos-Lira, Ricardo Orozco-Zavala
OBJECTIVE: Describe the occurrence of potentially traumatic events (PTE) in high-school students, measure subthreshold post-traumatic symptomatology in those who still experience PTE repercussions and associate the symptomatology with sociodemographic and PTE characteristics. MATERIALS AND METHODS: Analytic transversal study carried out in a convenience sample of one thousand students from three high schools in the State of Mexico. The Scale for Post Traumatic Stress in University Students was applied...
November 2017: Salud Pública de México
Anil Gautam, Gregory G Wiseman, Marika L Goodman, Simon Ahmedpour, Daniel Lindsay, Adele Heyer, Harry Stalewski, Robert E Norton, Andrew V White
AIM: The Townsville Hospital and Health Service is the regional referral centre for children in the north of Queensland. Aboriginal and Torres Strait Islander (ATSI) people make up 7-10% of the population. Increasing numbers of children with paediatric thoracic empyema (pTE) are being referred to Townsville Hospital and Health Service for management. This study aims to describe the incidence rates, epidemiology, microbiology and trends of this disease in North Queensland over a 10-year period...
February 14, 2018: Journal of Paediatrics and Child Health
Qian Ding, Yong Wang, Dafang Zhuang
The appropriate spatial interpolation methods must be selected to analyze the spatial distributions of Potentially Toxic Elements (PTEs), which is a precondition for evaluating PTE pollution. The accuracy and effect of different spatial interpolation methods, which include inverse distance weighting interpolation (IDW) (power = 1, 2, 3), radial basis function interpolation (RBF) (basis function: thin-plate spline (TPS), spline with tension (ST), completely regularized spline (CRS), multiquadric (MQ) and inverse multiquadric (IMQ)) and ordinary kriging interpolation (OK) (semivariogram model: spherical, exponential, gaussian and linear), were compared using 166 unevenly distributed soil PTE samples (As, Pb, Cu and Zn) in the Suxian District, Chenzhou City, Hunan Province as the study subject...
February 7, 2018: Journal of Environmental Management
Wai Yew Yang, Tracy Burrows, Lesley MacDonald-Wicks, Lauren T Williams, Clare E Collins, Winnie Siew Swee Chee
BACKGROUND AND AIMS: Given the increasing prevalence of childhood obesity in Malaysia, examination of family environmental factors is warranted. Reviews from developed countries report inconsistent findings on the relationship between parental-child feeding practices and child weight-related health outcomes. The current study aimed to examine parent-child feeding practices by familial-child characteristics in Malaysia. MATERIALS AND METHOD: The Family Diet Study was conducted with urban Malay families and included a child aged 8-12 years and their main carer(s)...
February 2, 2018: Appetite
Yuki Shigemoto, Christine Robitschek
OBJECTIVE: This study examined the inconsistent relationship found between personal growth initiative (PGI) and posttraumatic stress symptoms (PTSS) by exploring potential subgroups. In addition, after identifying the subgroups, potential predictors of these subgroups were examined. PARTICIPANTS: Participants were 534 undergraduate students who experienced a potentially traumatic event (PTE). Data collection occurred from March 2013 - December 2014. METHODS: Because this was a preliminary study, archival data was used...
February 6, 2018: Journal of American College Health: J of ACH
Savaş Sedat Özsu, Zerrin Gürel Durmuş, Mustafa Buğra Coşkuner, Yılmaz Bülbül, Funda Öztuna, Tevfik Özlü
OBJECTIVES: In the last 20 years, with the use of computed tomography (CT) angiography, the number of patients diagnosed with pulmonary thromboembolism (PTE) has increased. At the same time, data show that pulmonary embolism mortality has also reduced in this duration. MATERIAL AND METHODS: In this study, we analyzed records of patients with PTE (using ICD's) in the hospital automation system from 2001 to 2013. Data regarding age, sex, date of diagnosis, diagnosis of cancer, hemodynamic status, initial and maintenance treatment, hospital length of stay, and hospital mortality were recorded...
July 2017: Turkish Thoracic Journal
Milton J Micallef
Pulmonary thrombo-embolism (PTE) is a common cause of death but is frequently undetected by clinicians in spite of advanced diagnostic techniques. The autopsy has traditionally been used to identify the rate of PTE in hospital patients, but the decline in autopsy rates - especially in hospitals - has led to insufficient recent data from which to comment with confidence on the true rate of death from latent PTE. Widespread prophylactic anticoagulation regimens against venous thrombosis may induce complacency amongst clinicians...
February 5, 2018: Forensic Science, Medicine, and Pathology
Mònica Iglesias, Eva Marguí, Francesc Camps, Manuela Hidalgo
Sewage sludge is used as a fertilizer replacement in agricultural soils for its chemical properties, such as organic matter content, and for its capability to improve physical soil characteristics like porosity. This is also an appealing disposal option for residue whose production is increasing worldwide. However, there is some concern about the presence of potentially toxic elements (PTEs) that can accumulate in soils and become available for crops. In this work, a study was conducted to evaluate the extractability and crops transfer of thirteen PTEs from soils that had been amended with biosolids each year for 15 years as a regular agricultural practice...
January 22, 2018: Waste Management
Fernanda Junqueira Salles, Ana Paula Sayuri Sato, Maciel Santos Luz, Déborah Inês Teixeira Fávaro, Francisco Jorge Ferreira, Wanderley da Silva Paganini, Kelly Polido Kaneshiro Olympio
The outsourcing informal home practices adopted in jewelry and fashion jewelry chain can cause toxic substance elimination in the effluents and raise a concern for its environmental impact. This study evaluates if this informal work alters the concentration of potentially toxic elements (PTEs: As, Cd, Cr total and Cr-VI, Cu, Hg, Ni, Pb, Sn, and Zn) in the sewage network. The sanitary sewage samples (n = 540) were collected in 15 manholes during two campaigns in three different areas of Limeira-SP, Brazil (industrial area, with informal work and without known industrial/informal activity)...
February 1, 2018: Environmental Science and Pollution Research International
Carisa De Anda, Steven Anuskiewicz, Philippe Prokocimer, Jose Vazquez
BACKGROUND: Acute bacterial skin and skin structure infections (ABSSSI) are a frequent cause of hospital admissions in the United States. Safe and effective outpatient treatments may lower ABSSSI-associated health care costs by reducing unnecessary hospital admissions. Using data from 2 phase 3 trials (ESTABLISH-1, NCT01170221; ESTABLISH-2, NCT01421511), this post-hoc analysis explored the efficacy and safety of tedizolid in an outpatient setting. METHODS: Subgroup analysis was performed on US outpatients (defined as patients who were not in hospital at the time of treatment initiation) with ABSSSI caused by presumed or proven gram-positive pathogens...
December 2017: Medicine (Baltimore)
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