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https://www.readbyqxmd.com/read/29045673/age-related-changes-in-the-mitochondria-of-human-mural-granulosa-cells
#1
Yifan Liu, Ming Han, Xiaoshuang Li, Hui Wang, Minyue Ma, Shihui Zhang, Yifan Guo, Shuling Wang, Yuanfen Wang, N Duan, Bing Xu, Jingwen Yin, Yuanqing Yao
STUDY QUESTION: What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? SUMMARY ANSWER: The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. WHAT IS KNOWN ALREADY: Mitochondria play an important role in the dialogue between the mGCs and oocytes. However, the underlying mechanism of mitochondrial dysfunction in mGCs in aging is still poorly understood...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29044536/effect-of-matrix-metalloproteinase-inhibitor-on-disrupted-e-cadherin-after-acid-exposure-in-the-human-nasal-epithelium
#2
Byoungjae Kim, Hyun-Ji Lee, Nu-Ri Im, Doh Young Lee, Cha Young Kang, Il-Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung-Kuk Baek, Tae Hoon Kim
OBJECTIVE: Laryngopharyngeal reflux disease (LPRD) is one of potential factors in recalcitrant chronic rhinosinusitis with or without polyps. An increase in junctional permeability in the nasal mucosa in LPRD may be due to disrupted protein bridge formation with cell-to-cell adhesion molecules such as E-cadherin. Despite the relationship between nasal mucosal inflammation and LPRD, the clear mechanism by which acid reflux affects the nasal epithelium remains unclear. METHODS: The expression levels and distribution patterns of E-cadherin in primary culture of nasal epithelial cells after acid exposure with or without dexamethasone and matrix metalloproteinase (MMP) inhibitor were determined using Western blot and immunocytochemistry...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29044524/effects-of-loss-of-occlusal-contact-on-the-expression-of-matrix-metalloproteinase-2-membrane-type-1-mmp-tissue-inhibitor-of-the-mmp-2-eruption-rate-organization-and-resistance-of-collagen-fibers-of-the-rat-incisor-periodontal-ligament
#3
N F Omar, J R Gomes, J S Neves, P D Novaes
BACKGROUND AND OBJECTIVE: This study investigated the effect of occlusal contact loss (induced by tooth shortening), on matrix metalloproteinase (MMP)-2, membrane type 1-MMP (MT1-MMP) and tissue inhibitor of the MMP-2 (TIMP-2) expressions in the periodontal ligament of the rat incisor, as well as eruption rate, resistance and collagen organization. MATERIAL AND METHODS: Male Wistar rats were distributed into a control group, denominated normofunctional group, whose lower teeth underwent a normal eruption process; and a hypofunctional group, whose lower left incisor teeth were shortened every 2 days during 14 days...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29043698/gene-polymorphism-of-matrix-metalloproteinase-9-in-asthenozoospermic-male-subjects
#4
Sina Mohagheghi, Iraj Khodadadi, Manoochehr Karami, Iraj Amiri, Heidar Tavilani
Background: Matrix metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T MMP-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aim to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. MATERIALS AND METHODS: A total of 400 subjects, including 200 fertile and 200 infertile men, were recruited for this casecontrol study...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29043533/corneal-cross-linking-has-no-effect-on-matrix-metalloproteinase-9-and-13-levels-during-fungal-keratitis-on-the-early-stage
#5
Ayse Kalkanci, Kamil Bilgihan, Huseyin Baran Ozdemir, Atiye Seda Yar Saglam, Funda Karakurt, Merve Erdogan
The aim of our study was to investigate matrix metalloproteinases, MMP-9 and MMP-13 levels, in the rabbit model of Fusarium and Candida keratitis treated by corneal cross-linking (PACK-CXL). Rabbit corneas were inoculated with fungal inoculum for keratitis. Each group divided into four subgroups, including un-treated group, PACK-CXL group, voriconazole group and PACK-CXL plus voriconazole group. PACK-CXL was applied with 0.25% riboflavin in accelerated Dresden protocol, and 0.1% voriconazole drops were administered...
October 17, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29043215/inhibitory-effect-of-hizikia-fusiformis-solvent-partitioned-fractions-on-invasion-and-mmp-activity-of-ht1080-human-fibrosarcoma-cells
#6
Seul-Gi Lee, Fatih Karadeniz, Jung Hwan Oh, Ga Hyun Yu, Chang-Suk Kong
Matrix metalloproteinases (MMPs) are endopeptidases that take significant roles in extracellular matrix degradation and therefore linked to several complications such as metastasis of cancer progression, oxidative stress, and hepatic fibrosis. Hizikia fusiformis, a brown algae, was reported to possess bioactivities, including but not limited to, antiviral, antimicrobial, and anti-inflammatory partly due to bioactive polysaccharide contents. In this study, the potential of H. fusiformis against cancer cell invasion was evaluated through the MMP inhibitory effect in HT1080 fibrosarcoma cells in vitro...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042973/the-efficacy-of-microsurgery-in-the-treatment-of-cerebral-aneurysm-rupture-and-its-effect-on-nf-%C3%AE%C2%BAb-mcp-1-and-mmp-9
#7
Xintong Zhang, Lei Chen, Feng Zheng, Yanli Du
The clinical efficacy of microsurgical neck clipping for the treatment of cerebral aneurysm rupture and its effect on serum nuclear factor κ-light-chain-enhancer of activated β cells (NF-κB), monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-9 (MMP-9) levels were investigated. A total of 56 patients with first occurrence of cerebral aneurysm rupture were enrolled from June 2015 to June 2016. These patients were divided into control (25 patients) and observation groups (31 patients) according to treatment received...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042587/mir-302b-suppresses-osteosarcoma-cell-migration-and-invasion-by-targeting-runx2
#8
Yuanlong Xie, Wenchao Sun, Zhouming Deng, Xiaobin Zhu, Chao Hu, Lin Cai
Osteosarcoma patients with lung metastasis and local invasion remain challenging to treat despite the significant contribution of the combination of surgery and neo-adjuvant chemotherapy. Our previous microarray study demonstrated that miR-302b had significantly lower expression in osteosarcoma cell lines than in osteoblast cell lines. In the present study, we further elucidated the role of miR-302b in regulating the migration and invasiveness of osteosarcoma. MiR-302b expression was markedly down-regulated in osteosarcoma cell lines and clinical tumour tissues...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042458/exenatide-modulates-tumor-endothelial-cell-interactions-in-human-ovarian-cancer-cells
#9
Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Klych-Ratuszny, Mohammad Reza F Aghdam, Michal Wozniak, Andrzej Witek, Agnieszka Wroblewska-Czech, Anna Cygal, Jerzy Wojnar, Tomasz Francuz
Diabetes and cancer are prevalent diseases whose incidence is increasing globally. Diabetic women have a moderate risk increase of ovarian cancer which have associated worse prognosis, reduced survival and shorter relapse-free survival. Incretin drugs such as Exenatide, a synthetic analogue of Exendin-4, and Liraglutide are used as therapy for the type 2 diabetes (T2D). We studied the effects of GLP-1 and Exendin-4 on migration, apoptosis and metalloproteinase production in two human ovarian cancer cells (SKOV-3 and CAOV-3)...
October 17, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29041375/automatic-fringe-enhancement-with-novel-bidimensional-sinusoids-assisted-empirical-mode-decomposition
#10
Chenxing Wang, Qian Kemao, Feipeng Da
Fringe-based optical measurement techniques require reliable fringe analysis methods, where empirical mode decomposition (EMD) is an outstanding one due to its ability of analyzing complex signals and the merit of being data-driven. However, two challenging issues hinder the application of EMD in practical measurement. One is the tricky mode mixing problem (MMP), making the decomposed intrinsic mode functions (IMFs) have equivocal physical meaning; the other is the automatic and accurate extraction of the sinusoidal fringe from the IMFs when unpredictable and unavoidable background and noise exist in real measurements...
October 2, 2017: Optics Express
https://www.readbyqxmd.com/read/29040909/treatment-with-fenofibrate-plus-a-low-dose-of-benznidazole-attenuates-cardiac-dysfunction-in-experimental-chagas-disease
#11
Ágata C Cevey, Gerardo A Mirkin, Martín Donato, María J Rada, Federico N Penas, Ricardo J Gelpi, Nora B Goren
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution of Chagas disease. Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation. In this study we investigated whether a PPAR-α agonist, Fenofibrate, improves cardiac function and inflammatory parameters in a murine model of T. cruzi infection. BALB/c mice were sequentially infected with two T...
October 7, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29040664/coumestrol-induces-mitochondrial-dysfunction-by-stimulating-ros-production-and-calcium-ion-influx-into-mitochondria-in-human-placental-choriocarcinoma-cells
#12
Whasun Lim, Changwon Yang, Muhah Jeong, Fuller W Bazer, Gwonhwa Song
STUDY QUESTION: Does coumestrol inhibit proliferation of human placental choriocarcinoma cells? SUMMARY ANSWER: Coumestrol promotes cell death in the choriocarcinoma cells by regulating ERK1/2 MAPK and JNK MAPK signaling pathways and through disruption of Ca2+ and ROS homeostasis. WHAT IS KNOWN ALREADY: A number of patients who suffer from choriocarcinomas fail to survive due to delayed diagnosis or a recurrent tumor and resistance to traditional chemotherapy using platinum-based agents and methotrexate...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040407/genetic-reduction-of-matrix-metalloproteinase-9-promotes-formation-of-perineuronal-nets-around-parvalbumin-expressing-interneurons-and-normalizes-auditory-cortex-responses-in-developing-fmr1-knock-out-mice
#13
Teresa H Wen, Sonia Afroz, Sarah M Reinhard, Arnold R Palacios, Kendal Tapia, Devin K Binder, Khaleel A Razak, Iryna M Ethell
Abnormal sensory responses associated with Fragile X Syndrome (FXS) and autism spectrum disorders include hypersensitivity and impaired habituation to repeated stimuli. Similar sensory deficits are also observed in adult Fmr1 knock-out (KO) mice and are reversed by genetic deletion of Matrix Metalloproteinase-9 (MMP-9) through yet unknown mechanisms. Here we present new evidence that impaired development of parvalbumin (PV)-expressing inhibitory interneurons may underlie hyper-responsiveness in auditory cortex of Fmr1 KO mice via MMP-9-dependent regulation of perineuronal nets (PNNs)...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040313/premature-aortic-smooth-muscle-cell-differentiation-contributes-to-matrix-dysregulation-in-marfan-syndrome
#14
Matthew Dale, Matthew P Fitzgerald, Zhibo Liu, Trevor Meisinger, Andrew Karpisek, Laura N Purcell, Jeffrey S Carson, Paul Harding, Haili Lang, Panagiotis Koutakis, Rishi Batra, Constance J Mietus, George Casale, Iraklis Pipinos, B Timothy Baxter, Wanfen Xiong
Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies of human and mouse aortic samples from late stage MFS demonstrate increased TGF-β activation/signaling and diffuse matrix changes. However, the role of the aortic smooth muscle cell (SMC) phenotype in early aneurysm formation in MFS has yet to be fully elucidated. As our objective, we investigated whether an altered aortic SMC phenotype plays a role in aneurysm formation in MFS. We describe previously unrecognized concordant findings in the aortas of a murine model of MFS, mgR, during a critical and dynamic phase of early development...
2017: PloS One
https://www.readbyqxmd.com/read/29040281/impaired-anti-fibrotic-effect-of-bone-marrow-derived-mesenchymal-stem-cell-in-a-mouse-model-of-pulmonary-paracoccidioidomycosis
#15
Julián Camilo Arango, Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Lina María Salazar-Peláez, Mauricio Rojas, Ángel González
Bone marrow-derived mesenchymal stem cells (BMMSCs) have been consider as a promising therapy in fibrotic diseases. Experimental models suggest that BMMSCs may be used as an alternative therapy to treat chemical- or physical-induced pulmonary fibrosis. We investigated the anti-fibrotic potential of BMMSCs in an experimental model of lung fibrosis by infection with Paracoccidioides brasiliensis. BMMSCs were isolated and purified from BALB/c mice using standardized methods. BALB/c male mice were inoculated by intranasal infection of 1...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29040228/analytical-pitfalls-of-therapeutic-drug-monitoring-of-thiopurines-in-inflammatory-bowel-disease-patients
#16
Melek Simsek, Berrie Meijer, Chris Jj Mulder, Adriaan A van Bodegraven, Nanne Kh de Boer
The use of thiopurines in the treatment of inflammatory bowel disease (IBD) can be optimized by application of therapeutic drug monitoring (TDM). In this procedure, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP) metabolites are monitored and related to therapeutic response and adverse events, respectively. Therapeutic drug monitoring of thiopurines, however, is hampered by several analytical limitations resulting in an impaired translation of metabolite levels to clinical outcome in IBD...
October 14, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#17
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29039608/livin-promotes-the-progression-and-metastasis-of-breast-cancer-through-the-regulation-of-epithelial%C3%A2-mesenchymal-transition-via-the-p38-gsk3%C3%AE-pathway
#18
Yanchun Han, Li Zhang, Wei Wang, Jia Li, Min Song
Epithelial-mesenchymal transition (EMT) plays a pivotal role in the invasion and metastasis of breast cancer. Livin is a recently identified member of the inhibitors of the apoptosis protein family, which has been revealed to facilitate the progression of several types of cancer. However, the role of Livin in EMT and metastasis of breast cancer and its underlying mechanisms are not fully elucidated. In the present study, the levels of Livin mRNA and protein expression were found to be elevated in breast cancer tissues and cell lines...
October 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039582/curcumol-inhibits-the-proliferation-of-gastric-adenocarcinoma-mgc-803-cells-via-downregulation-of-idh1
#19
Shilei Zang, Qiling Tang, Fangrui Dong, Huan Liu, Lili Li, Fang Guo, Xuediao Pan, Haorong Lin, Weibin Zeng, Zhaoxu Cai, Qibin Zhong, Ning Zang, Linquan Zang
Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its anticancer activity in GC are still unclear. In this study, the antitumor efficacy of curcumol was ascertained in human gastric adenocarcinoma MGC-803 cells. An MTT assay was used to assess the viability of the MGC-803 cells treated by curcumol. The results of the Annexin V/propidium iodide (PI) staining followed by fluorescence activated cell sorting (FACS) analysis demonstrated that the cell cycle was arrested in the G2/M phase by curcumol...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039573/antitumor-effects-of-baicalin-on-ovarian-cancer-cells-through-induction-of-cell-apoptosis-and-inhibition-of-cell-migration-in%C3%A2-vitro
#20
Chen Gao, Yinglu Zhou, Huatao Li, Xia Cong, Zhongling Jiang, Xin Wang, Rongfeng Cao, Wenru Tian
Baicalin, an active flavone isolated from Scutellaria baicalensis Georgi, has been demonstrated to induce various beneficial biochemical effects such as anti‑inflammatory, anti‑viral, and antitumor effects. However, the antitumor mechanism of baicalin is not well understood. In the present study, baicalin was demonstrated to inhibit the viability and migration of a widely used ovarian cancer cell line, A2780, in a dose‑dependent manner. MTT assays revealed that cell viability significantly decreased in ovarian cancer cells treated with baicalin compared with untreated cells, without effect on normal ovarian cells...
October 10, 2017: Molecular Medicine Reports
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