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https://www.readbyqxmd.com/read/29913441/chondroprotective-effects-of-hyaluronic-acid-chitosan-nanoparticles-containing-plasmid-dna-encoding-cytokine-response-modifier-a-in-a-rat-knee-osteoarthritis-model
#1
Pang-Hu Zhou, Bo Qiu, Rong-Hui Deng, Hua-Jie Li, Xiong-Feng Xu, Xi-Fu Shang
BACKGROUND/AIMS: Interleukin (IL)-1β plays an essential role in the pathophysiology of osteoarthritis (OA). Cytokine response modifier A (CrmA) can prevent the generation of active IL-1β. This study aimed to explore the chondroprotective effects of hyaluronic acid-chitosan nanoparticles containing plasmid DNA encoding CrmA (HA/CS-CrmA) in a rat OA model. METHODS: HA/CS-CrmA nanoparticles were synthesized through the complex coacervation of cationic polymers. The characteristics, toxicity, and transfection of the nanoparticles were investigated...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913390/orexin-a-prevents-degradation-of-the-articular-matrixes-in-human-primary-chondrocyte-culture
#2
Dong Wang, Hui Ren, Chunlong Li, Fanghe Liu, Guangzhi Wang, Fengjun Shi, Yuanxin Sun
Excessive production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) plays a key role in the pathophysiological development of osteoarthritis (OA). Orexin A is an important peptide of hypothalamic origin, which has displayed its multiple biological functions in several chronic diseases via activation of its specific G-protein coupled receptors, orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R). In this study, we aimed to characterize the protective effects of orexin A against IL-1β-induced degradation of articular cartilage matrixes in human chondrocytes...
June 15, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29913136/mmp-2-and-mmp-9-contribute-to-the-angiogenic-effect-produced-by-hypoxia-15-hete-in-pulmonary-endothelial-cells
#3
Ying Liu, Hongyue Zhang, Lixin Yan, Wei Du, Min Zhang, He Chen, Lixin Zhang, Guangqun Li, Jijin Li, Yinchu Dong, Daling Zhu
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are the predominant gelatinases in the developing lung. Studies have shown that the expression of MMP-2 and MMP-9 is upregulated in hypoxic fibroblasts, 15-hydroxyeicosatetraenoic acid (15-HETE) regulated fibroblasts migration via modulating MMP-2 or MMP-9, and that hypoxia/15-HETE is a predominant contributor to the development of pulmonary arterial hypertension (PAH) through increased angiogenesis. However, the roles of MMP-2 and MMP-9 in pulmonary arterial endothelial cells (PAECs) angiogenesis as well as the molecular mechanism of hypoxia-regulated MMP-2 and MMP-9 expression have not been identified...
June 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29912729/in-vitro-effects-of-the-fs50-protein-from-salivary-glands-of-xenopsylla-cheopis-on-voltage-gated-sodium-channel-activity-and-motility-of-mda-mb-231-human-breast-cancer-cells
#4
Bei Zhang, Zhenghui Deng, Baishuang Zeng, Shilong Yang, Xin Chen, Xueqing Xu, Jiguo Wu
Voltage-gated sodium channel activity enhances the motility and oncogene expression of metastasic cancer cells that express a neonatal alternatively spliced form of the NaV1.5 isoform. We reported previously that FS50, a salivary protein from Xenopsylla cheopis, showed inhibitory activity against the NaV1.5 channel when assayed in HEK 293T cells and antiarrhythmia effects on rats and monkeys after induction of arrhythmia by BaCl2. This study aims to identify the effect of FS50 on voltage-gated sodium channel activity and the motility of MDA-MB-231 human breast cancer cells in vitro...
June 16, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29911998/hif2%C3%AE-in-the-uterine-stroma-permits-embryo-invasion-and-luminal-epithelium-detachment
#5
Leona Matsumoto, Yasushi Hirota, Tomoko Saito-Fujita, Norihiko Takeda, Tomoki Tanaka, Takehiro Hiraoka, Shun Akaeda, Hidetoshi Fujita, Ryoko Shimizu-Hirota, Shota Igaue, Mitsunori Matsuo, Hirofumi Haraguchi, Mayuko Saito-Kanatani, Tomoyuki Fujii, Yutaka Osuga
Although it has been reported that hypoxia inducible factor 2 α (Hif2a), a major transcriptional factor inducible by low oxygen tension, is expressed in the mouse uterus during embryo implantation, its role in pregnancy outcomes remains unclear. This study aimed to clarify functions of uterine HIF using transgenic mouse models. Mice with deletion of Hif2a in the whole uterus (Hif2a-uKO mice) showed infertility due to implantation failure. Supplementation with progesterone (P4) and leukemia inhibitory factor (LIF) restored decidual growth arrest and aberrant position of implantation sites in Hif2a-uKO mice, respectively, but did not rescue pregnancy failure...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29910616/inhibitory-effect-of-au-pt-nss-on-proliferation-migration-and-invasion-of-ej-bladder-carcinoma-cells-involvement-of-cell-cycle-regulators-signaling-pathways-and-transcription-factor-mediated-mmp-9-expression
#6
Seung-Shick Shin, Dae-Hwa Noh, Byungdoo Hwang, Jo-Won Lee, Sung Lyea Park, Sung-Soo Park, Bokyung Moon, Wun-Jae Kim, Sung-Kwon Moon
Background: Although the diverse biological properties of nanoparticles have been studied intensively, research into their mechanism of action is relatively rare. In this study, we investigated the molecular mechanisms of the anticancer activity of heterometallic Au@Pt-nanoseeds (NSs) against bladder cancers. Materials and methods: Mode of action of Au@Pt-NSs was investigated through MTT assay, flow cytometry analysis, Western immunoblots, real-time qPCR, wound-healing migration and invasion assays, zymography, and electrophoretic mobility shift assay (EMSA)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29910615/preparation-characterizations-and-anti-pollutant-activity-of-7-3-4-trihydroxyisoflavone-nanoparticles-in-particulate-matter-induced-hacat-keratinocytes
#7
Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee, Feng-Lin Yen
Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29910491/a-randomised-comparative-study-on-customised-versus-fixed-sized-pillow-for-tracheal-intubation-in-the-sniffing-position-by-macintosh-laryngoscopy
#8
Mridul Dhar, Habib Md Reazaul Karim, Narayanan Rajaram, Avinash Prakash, Sarasa K Sahoo, Anilkumar Narayan
Background and Aims: The sniffing position has been most commonly used for positioning of the head and neck to facilitate tracheal intubation. However, the optimum degree of head elevation for the optimal laryngeal view is not well studied, especially in non-Western countries. The present study was aimed to compare the use of a fixed height pillow versus a customised pillow (CP) height for head elevation, in terms of glottis visualisation and time required for tracheal intubation. Methods: With research and ethics committee approval from the institute, this randomised study was conducted among patients of both sexes aged 16 years or more and American Society of Anesthesiologists physical Status I to IV...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910348/the-validity-of-external-internal-training-load-ratios-in-rested-and-fatigued-soccer-players
#9
Ibrahim Akubat, Steve Barrett, Manuel Lapuente Sagarra, Grant Abt
PURPOSE: To examine the relationship of external:internal training load ratios with fitness and assess the impact of fatigue. METHOD: Ten soccer players performed a lactate threshold test followed by two soccer simulations (BEAST90mod ) 48 h apart. Recovery (TQR) and muscle soreness (DOMS) was measured before each trial. Internal Training load (TL) (iTRIMP) and external load total distance (TD), high intensity distance (HID), PlayerLoad™ (PL) mean metabolic power (MMP) high metabolic power distance (HP) were collected for each trial and external:internal ratios produced...
May 19, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29909038/engineered-stem-cell-mimics-to-enhance-stroke-recovery
#10
Paul M George, Byeongtaek Oh, Ruby Dewi, Thuy Hua, Lei Cai, Alexa Levinson, Xibin Liang, Brad A Krajina, Tonya M Bliss, Sarah C Heilshorn, Gary K Steinberg
Currently, no medical therapies exist to augment stroke recovery. Stem cells are an intriguing treatment option being evaluated, but cell-based therapies have several challenges including developing a stable cell product with long term reproducibility. Since much of the improvement observed from cellular therapeutics is believed to result from trophic factors the stem cells release over time, biomaterials are well-positioned to deliver these important molecules in a similar fashion. Here we show that essential trophic factors secreted from stem cells can be effectively released from a multi-component hydrogel system into the post-stroke environment...
June 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29908885/microrna-188-5p-regulates-contribution-of-bone-marrow-derived-cells-to-choroidal-neovascularization-development-by-targeting-mmp-2-13
#11
Huiyuan Hou, Fan Gao, Hongliang Liang, Yang Lv, Manhong Li, Libo Yao, Jian Zhang, Guorui Dou, Yusheng Wang
Our previous investigations have shown that bone marrow-derived cells (BMCs), including mesenchymal stem cells (MSCs), contribute to the development of choroidal neovascularization (CNV) as sources of cells and angiogenic factors. Two main steps for circulating BMCs to integrate into CNV lesions are extracellular matrix remodeling and consequential cell migration. MicroRNAs (miRNAs) were found to be involved in CNV development; however, little is known about whether miRNAs regulate the contribution of BMCs to CNV...
June 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29908794/liquiritigenin-and-liquiritin-alleviated-mct-induced-hsos-by-activating-nrf2-antioxidative-defense-system
#12
Zhenlin Huang, Yuchen Sheng, Minwei Chen, Zhanxia Hao, Feifei Hu, Lili Ji
Hepatic sinusoidal obstruction syndrome (HSOS) is a serious and life-threatening liver disease. Liquiritigenin (LG) and liquiritin (LQ) are natural flavonoids distributed in Glycyrrhizae Radix et Rhizoma (Gan-cao). This study aims to investigate the protective effect and mechanism of LG and LQ against monocrotaline (MCT)-induced HSOS. Results of serum alanine/aspartate aminotransferases (ALT/AST) activities, liver histological evaluation and scanning electron microscope observation, and hepatic metalloproteinase-9 (MMP-9) expression demonstrated that LG and LQ both alleviated HSOS induced by MCT in rats...
June 14, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29908722/ferulic-acid-a-dietary-polyphenol-suppresses-osteoclast-differentiation-and-bone-erosion-via-the-inhibition-of-rankl-dependent-nf-%C3%AE%C2%BAb-signalling-pathway
#13
Hari Madhuri Doss, Snigdha Samarpita, Ramamoorthi Ganesan, Mahaboobkhan Rasool
AIMS: Bone erosion induced by enhanced osteoclast formation is a debilitating pathological phenomenon in rheumatoid arthritis (RA). Recent finding has revealed that ferulic acid is associated with reduced osteoclast differentiation and bone erosion. However, the underlying mechanism through which ferulic acid inhibited osteoclast differentiation and bone erosion still remains to be elucidated. This study assessed the therapeutic effects of ferulic acid on osteoclast differentiation and bone erosion by targeting RANKL dependent NF-κB pathway...
June 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29908344/nitroxide-radical-containing-nanoparticles-attenuate-tumorigenic-potential-of-triple-negative-breast-cancer
#14
Babita Shashni, Yukio Nagasaki
The critical importance of reactive oxygen species (ROS) as oncogene activators and essential secondary messengers in cancer cell survival have been widely reported. Since oxidative stress has been implicated as being pivotal in various cancers, antioxidant therapy seems an apt strategy to abrogate ROS-mediated cellular processes to attenuate cancers. We therefore synthesized ROS scavenging nitroxide radical-containing nanoparticles (RNPs); pH insensitive RNPO and pH sensitive RNPN , to impede the proliferative and metastatic characteristics of the triple negative breast cancer cell line, MDA-MB-231, both in vitro and in vivo...
May 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/29908226/visfatin-alters-the-cytokine-and-matrix-degrading-enzyme-profile-during-osteogenic-and-adipogenic-msc-differentiation
#15
Lali Tsiklauri, Janina Werner, Marian Kampschulte, Klaus W Frommer, Lucija Berninger, Martina Irrgang, Kristina Glenske, Dirk Hose, Thaqif El Khassawna, Jörn Pons-Kühnemann, Stefan Rehart, Sabine Wenisch, Ulf Müller-Ladner, Elena Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g. visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis. Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and RNA were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 13, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29908163/matrix-metalloproteinases-are-regulated-by-microrna-320-in-macrophages-and-are-associated-with-aortic-dissection
#16
Mingfang Liao, Sili Zou, Yan Bao, Jie Jin, Junlin Yang, Yandong Liu, Mark Green, Futang Yang, Lefeng Qu
Aortic dissection (AD) is the circumferential or transversal tear of the aorta wall that allows blood to infiltrate the layers. MicroRNA (miR) analyses have demonstrated a correlation between miR-320 family and AD. The underlying mechanism is yet unclear. The matrix metalloproteinases (MMPs) are a group of proteolytic enzymes that could catalyze the degeneration of the extracellular matrix and the destruction of the vasculature. In this study, we investigated whether miR-320 presented a role in regulating the production of MMPs in aortic dissection...
June 13, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29908007/cocl-2-a-mimic-of-hypoxia-enhances-bone-marrow-mesenchymal-stem-cells-migration-and-osteogenic-differentiation-via-stat3-signaling-pathway
#17
Xin Yu, Qilong Wan, Gu Cheng, Xin Cheng, Jing Zhang, Janak L Pathak, Zubing Li
Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in fracture site induces bone marrow mesenchymal stem cells (BMSCs) migration, but its mechanism remains unclear. Our previous study and studies by other groups have reported the involvement of signal transducer and activator of transcription 3 (STAT3) pathway in cell migration. However, the role of STAT3 pathway in hypoxia-induced cell migration is still unknown. In this study, we investigated the role of STAT3 signaling in hypoxia-induced BMSCs migration and osteogenic differentiation...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29908000/serpin-a1-and-the-modulation-of-type-i-collagen-turnover-effect-of-the-c-terminal-peptide-409-418-sa1-iii-in-human-dermal-fibroblasts
#18
Caterina Cipriani, Simona Pascarella, Fosca Errante, Beatrice Menicacci, Lucia Magnelli, Alessandra Mocali, Paolo Rovero, Lisa Giovannelli
The pharmacological modulation of collagen turnover is a strategy potentially useful in different skin conditions. The serine protease inhibitor Serpin A1 and portions of its C-terminal region have been investigated as collagen modulators. To clarify the mechanisms by which the C-terminal 409-418 peptide SA1-III increases extracellular type I collagen levels, to compare its activities range with that of the originator molecule Serpin A1, and to evaluate its efficacy in primary cultures from adult and aged human subjects...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29906745/long-noncoding-rna-linc00460-targets-mir-539-mmp-9-to-promote-meningioma-progression-and-metastasis
#19
Hongshun Xing, Shilei Wang, Quancai Li, Yongqian Ma, Peng Sun
Emerging evidence reveal that long noncoding RNAs (lncRNAs) participates in the epigenetic regulation of pathophysiological process. However, the deepgoing role of lncRNAs on meningioma is still unclear. In present study, we investigate the roles of lncRNA LINC00460 in meningeoma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningeoma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906536/mahuang-decoction-mitigates-airway-inflammation-and-regulates-il-21-stat3-signaling-pathway-in-rat-asthma-model
#20
Yu He, Xiaohui Lou, Zhan Jin, Li Yu, Ling Deng, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma...
June 12, 2018: Journal of Ethnopharmacology
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