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https://www.readbyqxmd.com/read/29684681/quantitative-proteomics-identify-an-association-between-extracellular-matrix-degradation-and-immunopathology-of-genotype-vii-newcastle-disease-virus-in-the-spleen-in-chickens
#1
Zenglei Hu, Han Gu, Jiao Hu, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Xinan Jiao, Xiufan Liu
Pathogenesis of genotype VII Newcastle disease virus (NDV) is characterized with remarkable immunopathology in the spleen in chickens. However, the mechanism for this unique pathological phenotype is not fully understood. Previous transcriptomics data showed that genotype VII NDV JS5/05 caused a greater downregulation of extracellular matrix (ECM) genes than genotype IV virus Herts/33 in the spleen. In this study, the role of ECM in pathology of genotype VII NDV was investigated using quantitative proteomics...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684479/impairment-of-the-gn%C3%AE-11-controlled-expression-of-claudin-1-and-mmp-9-and-collective-migration-of-human-breast-cancer-mcf-7-cells-by-dheas
#2
Neha Upmanyu, Ahmed Bulldan, Dimitrios Papadopoulos, Raimund Dietze, Viveka Nand Malviya, Georgios Scheiner-Bobis
Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. We address here DHEAS effects on the estrogen receptor-positive metastatic human breast cancer cell line MCF-7. We focus on DHEAS-mediated signaling that might influence expression of claudin-1 and matrix metalloproteinase-9 (MMP-9), both known to be critical factors for migration and invasiveness of various cancers, including breast cancer cells. Physiological concentrations of DHEAS trigger persistent phosphorylation of Erk1/2 in MCF-7 cells...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29683731/bronchiolitis-obliterans-murine-model-induced-by-nitric-acid-aerosol-inhalation-an-economical-and-reproducible-model
#3
Jianing Yin, Xiaobo Ma, Fei Huang, Yucong Ma, Yanan Li
PURPOSE: Bronchiolitis obliterans (BO) is a highly debilitative and fatal syndrome associated with a series of severe lower airway disorders. The pathogenesis of BO is complicated and not entirely understood. An appropriate animal model of BO may aid research into its pathogenesis. Here, we establish a mouse model of BO to provide insight into this disease. MATERIALS AND METHODS: 6-8 week old BABL/c mice were exposed to 5% nitric acid (NA) aerosol through a nebulizer for 3 hours, and controls were exposed to distilled water instead...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29683683/sequentially-responsive-therapeutic-peptide-assembling-nanoparticles-for-dual-targeted-cancer-immunotherapy
#4
Keman Cheng, Yanping Ding, Ying Zhao, Shefang Ye, Xiao Zhao, Yinlong Zhang, Tianjiao Ji, Huanhuan Wu, Bin Wang, Gregory J Anderson, Lei Ren, Guangjun Nie
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential for steady co-delivery of various drugs, especially small molecules, therapeutic peptides, and nucleic acids, thereby realizing controllable drug release, increase of drug bioavailability and reduction of adverse effects. Herein, a therapeutic peptide assembling nanoparticle that can sequentially respond to dual stimuli in the tumor extracellular matrix was designed for tumor-targeted delivery and on-demand release of a short D-peptide antagonist of programmed cell death-ligand 1 (D PPA-1) and an inhibitor of idoleamine 2, 3-dioxygenase (NLG919)...
April 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29683364/inflammatory-biomarkers-in-saliva-and-serum-of-patients-with-rheumatoid-arthritis-with-respect-to-periodontal-status
#5
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Leena Laasonen, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. METHODS: 53 early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug...
April 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29682689/effect-evaluation-of-methylprednisolone-plus-mitochondrial-division-inhibitor-1-on-spinal-cord-injury-rats
#6
Xu-Gui Chen, Li-Hua Chen, Ru-Xiang Xu, Hong-Tian Zhang
PURPOSE: To investigate the combination effect of methylprednisolone (MP) and mitochondrial division inhibitor-1 (Mdivi-1) on the neurological function recovery of rat spinal cord injury (SCI) model. METHODS: The weight-drop method was used to establish the rat SCI model; then, rats were randomized into sham group, SCI group, MP group, Mdivi-1 group and MP+Mdivi-1 group. Motor function scores were quantified to evaluate locomotor ability; HE staining was used to assess spinal cord histopathology; tissue water content, oxidative stress, tissue mitochondrial function, neurons apoptosis, and apoptosis-related protein expression were detected...
April 23, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29682576/effects-of-pravastatin-on-type-1-diabetic-rat-heart-with-or-without-blood-glycemic-control
#7
Jeong Jin Min, Byung-Seop Shin, Jong-Hwan Lee, Yunseok Jeon, Dae Kyun Ryu, Sojin Kim, Young Hee Shin
Although statins have been suggested to attenuate the progression of diabetic cardiomyopathy, its effect without glycemic control remains unclear. Therefore, we evaluated the effect of pravastatin on diabetic rat hearts according to glycemic control. Rats were randomly divided into five groups: control (C), diabetes (D), diabetes with insulin (I), diabetes with pravastatin (P), and diabetes with insulin and pravastatin (IP). Eight weeks after allocated treatments, the heart was extracted and analyzed following echocardiography...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682561/anti-inflammatory-effect-of-geniposide-on-osteoarthritis-by-suppressing-the-activation-of-p38-mapk-signaling-pathway
#8
Yuan Chen, Kangquan Shou, Chunlong Gong, Huarui Yang, Yi Yang, Tongzhu Bao
It has been suggested that the activation of the p38 mitogen activated protein kinases (MAPKs) signaling pathway plays a significant role in the progression of OA by leading to the overexpression of proinflammatory cytokines, chemokines, and signaling enzymes in human osteoarthritis chondrocytes. However, most p38 MAPK inhibitors applied for OA have been thought to be limited due to their potential long-term toxicities. Geniposide (GE), an iridoid glycoside purified from the fruit of the herb, has been widely used in traditional medicine for the treatment of a variety of chronic inflammatory diseases...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682558/dream-is-involved-in-the-genesis-of-inflammation-induced-prolabour-mediators-in-human-myometrial-and-amnion-cells
#9
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor- κ B (NF- κ B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF- κ B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682182/anti-cancerous-effect-of-cis-khellactone-from-angelica-amurensis-through-the-induction-of-three-programmed-cell-deaths
#10
Samil Jung, Hyung-In Moon, Beom Suk Lee, Subeen Kim, Nguyen Thi Ngoc Quynh, Jimin Yu, Dan-Diem Thi Le, Zolzaya Sandag, Hyegyeong Lee, Hyojeong Lee, Nguyen Hai Anh, Young Yang, Jong-Seok Lim, Keun-Il Kim, Myeong-Sok Lee
Angelica amurensis has traditionally been used to treat various medical problems. In this report, we introduce cis-khellactone as a new anti-cancer agent, which was isolated from the chloroform soluble fraction of the rhizomes of Angelica amurensis . Its anti-cancerous effect was at first tested in MCF7 and MDA-MB-231 breast cell lines, in which MCF7 is well known to be resistant to many anti-cancer drugs; MCF10A normal breast cell line was used as a control. In vitro experiments showed that cis-khellactone suppressed cell growth and proliferation at a relatively low concentrations (<5 μg/ml) and decreased cell viability at high concentrations (>10 μg/ml) in both cancer cell lines in a time- and concentration-dependent manner...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29682175/alcam-shedding-at-the-invasive-front-of-the-tumor-is-a-marker-of-myometrial-infiltration-and-promotes-invasion-in-endometrioid-endometrial-cancer
#11
Laura Devis, Elena Martinez-Garcia, Cristian P Moiola, Maria Teresa Quiles, Maria Antonia Arbos, Tomita Vasilica Stirbat, Françoise Brochard-Wyart, Ángel García, Lorena Alonso-Alconada, Miguel Abal, Berta Diaz-Feijoo, William Thomas, Sylvie Dufour, Gemma Mancebo, Francesc Alameda, Jaume Reventos, Antonio Gil-Moreno, Eva Colas
Endometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and mortality. In this study, ALCAM, a previously described marker of EC recurrence, was studied by immunohistochemistry at the superficial and the invasive tumor areas from 116 EC patients with different degree of myometrial invasion and related to a set of relevant epithelial and mesenchymal markers. ALCAM expression presented a heterogeneous functionality depending on its localization, it correlated with epithelial markers (E-cadherin/β-catenin) at the superficial area, and with mesenchymal markers at the invasive front (COX-2, SNAIL, ETV5, and MMP-9)...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29682112/cytokine-profile-of-human-abdominal-aortic-aneurysm-involvement-of-jak-stat-pathway
#12
Tomokazu Ohno, Hiroki Aoki, Satoko Ohno, Michihide Nishihara, Aya Furusho, Shinichi Hiromatsu, Hidetoshi Akashi, Yoshihiro Fukumoto, Hiroyuki Tanaka
Objective : Abdominal aortic aneurysm (AAA) is characterized by inflammation and destruction of normal tissue architecture. The present study aimed to evaluate the inflammatory signaling cascade by analyzing the cytokines of AAA tissue. Materials and Methods : We analyzed the comprehensive cytokine secretion profiles of 52 cytokines from human AAA in four patients with AAA using fluorescent beads-based multiplex assay. Further, the effect of janus kinase (JAK) inhibition by pyridone 6 on cytokine profiles was also evaluated...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681903/inflammatory-mediator-profiles-differ-in-sepsis-patients-with-and-without-bacteremia
#13
Knut Anders Mosevoll, Steinar Skrede, Dagfinn Lunde Markussen, Hans Rune Fanebust, Hans Kristian Flaatten, Jörg Aßmus, Håkon Reikvam, Øystein Bruserud
Systemic levels of cytokines are altered during infection and sepsis. This prospective observational study aimed to investigate whether plasma levels of multiple inflammatory mediators differed between sepsis patients with and those without bacteremia during the initial phase of hospitalization. A total of 80 sepsis patients with proven bacterial infection and no immunosuppression were included in the study. Plasma samples were collected within 24 h of hospitalization, and Luminex® analysis was performed on 35 mediators: 16 cytokines, six growth factors, four adhesion molecules, and nine matrix metalloproteases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29680963/anti-inflammatory-and-anti-angiogenic-activities-in-vitro-of-eight-diterpenes-from-daphne-genkwa-based-on-hierarchical-cluster-and-principal-component-analysis
#14
Ling Wang, Xin-Yi Lan, Jun Ji, Chun-Feng Zhang, Fei Li, Chong-Zhi Wang, Chun-Su Yuan
Rheumatoid arthritis (RA) is one of the most prevalent chronic inflammatory and angiogenic diseases. The aim of this study was to evaluate the anti-inflammatory and anti-angiogenic activities in vitro of eight diterpenoids isolated from Daphne genkwa. LC-MS was used to identify diterpenes isolated from D. genkwa. The anti-inflammatory and anti-angiogenic activities of eight diterpenoids were evaluated on LPS-induced macrophage RAW264.7 cells and TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) using hierarchical cluster analysis (HCA) and principal component analysis (PCA)...
April 21, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29680691/from-the-lung-to-the-knee-joint-toxicity-evaluation-of-carbon-black-nanoparticles-on-macrophages-and-chondrocytes
#15
Juan Ma, Anyi Guo, Shunhao Wang, Siliang Man, Yunjian Zhang, Sijin Liu, Yajun Liu
Carbon black (CB), a core elemental carbon component of airborne particles, has been used as a model material to study environmental safety and health impacts of airborne particles. Although potential adverse effects of CB have been reported, limited knowledge is available regarding CB-induced metabolic disorders and secondary effects distant from primary target organs, such as the effects on joints. The knee cavity is a relatively closed space along the peripheral circulation route with a slow rate of interchange of nutrition with blood...
April 13, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29680481/mycobacterium-avium-lysate-induces-matrix-metalloproteinase-1-in-intestinal-tissue-and-peripheral-blood-observations-from-selected-hospital-based-zambian-adults
#16
Gershom Chongwe, Charles Michelo, Edford Sinkala, Violet Kayamba, Jean-Baptiste Nzayisenga, Francis Drobniewski, Paul Kelly
OBJECTIVES: Environmental enteropathy is prevalent in low-income countries, although its aetiology is unknown. We investigated if Mycobacterium avium antigens, which are commonly found in the environment, could contribute to its pathogenesis in a population known to have widespread environmental enteropathy. METHODS: Routine endoscopy patients at the University Teaching Hospital, Lusaka whose endoscopy results were normal submitted duodenal biopsies and whole blood samples...
April 19, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29679944/epigallocatechin-3-gallate-attenuates-microcystin-lr-induced-apoptosis-in-human-umbilical-vein-endothelial-cells-through-activation-of-the-nrf2-ho-1-pathway
#17
Jun Shi, Min Zhang, Libin Zhang, Huipin Deng
Our previous study showed that the tea extract, epigallocatechin-3-gallate (EGCG), protects against microcystin-LR (MC-LR) -mediated apoptosis of human umbilical vein endothelial cells (HUVECs); however, the mechanism underlying MC-LR-induced HUVEC apoptosis remains incompletely understood. In this study, we investigated whether the nuclear factor erythroid-like 2 (NRF2)/heme oxygenase-1 (HO-1) pathway, which regulates antioxidant transcriptional regulation of oxidative stress and apoptosis, is involved in this process...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679755/long-non-coding-rna-xist-sponges-mir-34a-to-promotes-colon-cancer-progression-via-wnt-%C3%AE-catenin-signaling-pathway
#18
Ningning Sun, Guozun Zhang, Yingying Liu
Little is known about the role of long non-coding RNA XIST in the development of colon cancer. The aim of the present study was to investigate the levels of XIST in colon cancer, and explore its underlying mechanism. In this study, we found XIST expression level was upregulated in colon cancer tissues and cell lines. In addition, the growth rate of cells transfected with si-XIST was significantly decreased compared to that with si-NC, which was reversed by miR-34a targeted with 3'-UTR. Moreover, miR-34a suppressed the expression of WNT1 by binding with the 3'-UTR, which interact with WNT1 to inhibit the proliferation of cells...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679319/multifunctional-self-assembling-peptide-based-nanostructures-for-targeted-intracellular-delivery-design-physicochemical-characterization-and-biological-assessment
#19
Yejiao Shi, Ran Lin, Honggang Cui, Helena S Azevedo
Peptide amphiphiles (PAs), consisting of a hydrophobic alkyl chain covalently bound to a hydrophilic peptide sequence, possess a versatile molecular design due to their combined self-assembling features of amphiphile surfactants and biological functionalities of peptides. Through rational design, PAs can self-assemble into a variety of nanostructures with controlled shape, size, and biological functionality to deliver therapeutic and imaging agents to target cells. Here, we describe principles to design multifunctional PAs for self-assembly into micellar nanostructures and targeted intracellular delivery...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679218/targeting-matrix-metalloproteinases-with-novel-diazepine-substituted-cinnamic-acid-derivatives-design-synthesis-in-vitro-and-in-silico-studies
#20
Dharmender Rathee, Viney Lather, Ajmer Singh Grewal, Harish Dureja
Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogenesis, which suggests that creating potent MMP-2 and -9 inhibitors, should be an important goal in lung cancer therapy. In the present study, an effort has been made to develop new anti-metastatic and anti-invasive agents, wherein a series of novel diazepine substituted cinnamic acid derivatives were designed, synthesized and assayed for their inhibitory activities on MMP-2 and MMP-9...
April 20, 2018: Chemistry Central Journal
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