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https://www.readbyqxmd.com/read/28087765/synapsin-ii-regulation-of-gabaergic-synaptic-transmission-is-dependent-on-interneuron-subtype
#1
Pedro Feliciano, Heidi Matos, Rodrigo Andrade, Maria Bykhovskaia
: Synapsins are epilepsy susceptibility genes that encode phosphoproteins reversibly associated with synaptic vesicles. Synapsin II (SynII) gene deletion produces a deficit in inhibitory synaptic transmission, and this defect is thought to cause epileptic activity. We systematically investigated how SynII affects synchronous and asynchronous release components of inhibitory transmission in the CA1 region of the mouse hippocampus. We found that the asynchronous GABAergic release component is diminished in SynII deleted (SynII(-)) slices...
January 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28071723/hcn1-channels-reduce-the-rate-of-exocytosis-from-a-subset-of-cortical-synaptic-terminals
#2
Zhuo Huang, Gengyu Li, Carolina Aguado, Rafael Lujan, Mala M Shah
The hyperpolarization-activated cyclic nucleotide-gated (HCN1) channels are predominantly located in pyramidal cell dendrites within the cortex. Recent evidence suggests these channels also exist pre-synaptically in a subset of synaptic terminals within the mature entorhinal cortex (EC). Inhibition of pre-synaptic HCN channels enhances miniature excitatory post-synaptic currents (mEPSCs) onto EC layer III pyramidal neurons, suggesting that these channels decrease the release of the neurotransmitter, glutamate...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065934/brain-cannabinoid-receptor-2-expression-function-and-modulation
#3
REVIEW
De-Jie Chen, Ming Gao, Fen-Fei Gao, Quan-Xi Su, Jie Wu
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid receptor (CBR) subtypes. The prevailing view is that CB1Rs are mainly expressed in the central neurons, whereas CB2Rs are predominantly expressed in peripheral immune cells...
January 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28065605/early-commissural-diencephalic-neurons-control-habenular-axon-extension-and-targeting
#4
Carlo A Beretta, Nicolas Dross, Luca Guglielmi, Peter Bankhead, Marina Soulika, Jose A Gutierrez-Triana, Alessio Paolini, Lucia Poggi, Julien Falk, Soojin Ryu, Marika Kapsimali, Ulrike Engel, Matthias Carl
Most neuronal populations form on both the left and right sides of the brain. Their efferent axons appear to grow synchronously along similar pathways on each side, although the neurons or their environment often differ between the two hemispheres [1-4]. How this coordination is controlled has received little attention. Frequently, neurons establish interhemispheric connections, which can function to integrate information between brain hemispheres (e.g., [5]). Such commissures form very early, suggesting their potential developmental role in coordinating ipsilateral axon navigation during embryonic development [4]...
December 29, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28063948/cytokine-il-10-activators-of-pi3-kinase-agonists-of-%C3%AE-2-adrenoreceptor-and-antioxidants-prevent-ischemia-induced-cell-death-in-rat-hippocampal-cultures
#5
Egor A Turovsky, Maria V Turovskaya, Sergei G Gaidin, Valery P Zinchenko
In the present work we compared the protective effect of anti-inflammatory cytokine IL-10 with the action of a PI3-kinase selective activator 740 Y-P, selective agonists of alpha-2 adrenoreceptor, guanfacine and UK-14,304, and compounds having antioxidant effect: recombinant human peroxiredoxin 6 and B27, in hippocampal cell culture during OGD (ischemia-like conditions). It has been shown that the response of cells to OGD in the control includes two phases. The first phase was accompanied by an increase in the frequency of spontaneous synchronous Ca(2+)-oscillations (SSCO) in neurons and Ca(2+)-pulse in astrocytes...
January 4, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28055918/stability-of-rotor-hopfield-neural-networks-with-synchronous-mode
#6
Masaki Kobayashi
A complex-valued Hopfield neural network (CHNN) is a model of a Hopfield neural network using multistate neurons. The stability conditions of CHNNs have been widely studied. A CHNN with a synchronous mode will converge to a fixed point or a cycle of length 2. A rotor Hopfield neural network (RHNN) is also a model of a multistate Hopfield neural network. RHNNs have much higher storage capacity and noise tolerance than CHNNs. We extend the theories regarding the stability of CHNNs to RHNNs. In addition, we investigate the stability of RHNNs with the projection rule...
December 29, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28054545/temporal-coherence-structure-rapidly-shapes-neuronal-interactions
#7
Kai Lu, Yanbo Xu, Pingbo Yin, Andrew J Oxenham, Jonathan B Fritz, Shihab A Shamma
Perception of segregated sources is essential in navigating cluttered acoustic environments. A basic mechanism to implement this process is the temporal coherence principle. It postulates that a signal is perceived as emitted from a single source only when all of its features are temporally modulated coherently, causing them to bind perceptually. Here we report on neural correlates of this process as rapidly reshaped interactions in primary auditory cortex, measured in three different ways: as changes in response rates, as adaptations of spectrotemporal receptive fields following stimulation by temporally coherent and incoherent tone sequences, and as changes in spiking correlations during the tone sequences...
January 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28052448/the-can-in-network-a-biologically-inspired-model-for-self-sustained-theta-oscillations-and-memory-maintenance-in-the-hippocampus
#8
Francesco Giovannini, Beate Knauer, Motoharu Yoshida, Laure Buhry
During working memory tasks, the hippocampus exhibits synchronous theta-band activity, which is thought to be correlated with the short-term memory maintenance of salient stimuli. Recent studies indicate that the hippocampus contains the necessary circuitry allowing it to generate and sustain theta oscillations without the need of extrinsic drive. However, the cellular and network mechanisms supporting synchronous rhythmic activity are far from being fully understood. Based on electrophysiological recordings from hippocampal pyramidal CA1 cells, we present a possible mechanism for the maintenance of such rhythmic theta-band activity in the isolated hippocampus...
January 3, 2017: Hippocampus
https://www.readbyqxmd.com/read/28049647/regulating-the-suprachiasmatic-nucleus-scn-circadian-clockwork-interplay-between-cell-autonomous-and-circuit-level-mechanisms
#9
REVIEW
Erik D Herzog, Tracey Hermanstyne, Nicola J Smyllie, Michael H Hastings
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous transcription-based clockwork but, in turn, circuit-level interactions synchronize the 20,000 or so SCN neurons into a robust and coherent daily timer. Synchronization requires neuropeptide signaling, regulated by a reciprocal interdependence between the molecular clockwork and rhythmic electrical activity, which in turn depends on a daytime Na(+) drive and nighttime K(+) drag...
January 3, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28043892/genetic-influences-on-functional-connectivity-associated-with-feedback-processing-and-prediction-error-phase-coupling-of-theta-band-oscillations-in-twins
#10
Şükrü Barış Demiral, Simon Golosheykin, Andrey P Anokhin
Detection and evaluation of the mismatch between the intended and actually obtained result of an action (reward prediction error) is an integral component of adaptive self-regulation of behavior. Extensive human and animal research has shown that evaluation of action outcome is supported by a distributed network of brain regions in which the anterior cingulate cortex (ACC) plays a central role, and the integration of distant brain regions into a unified feedback-processing network is enabled by long-range phase synchronization of cortical oscillations in the theta band...
December 30, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28042984/transcranial-direct-current-stimulation-modulates-offline-visual-oscillatory-activity-a-magnetoencephalography-study
#11
Elizabeth Heinrichs-Graham, Timothy J McDermott, Mackenzie S Mills, Nathan M Coolidge, Tony W Wilson
Transcranial direct-current stimulation (tDCS) is a noninvasive neuromodulatory method that involves delivering low amplitude, direct current to specific regions of the brain. While a wealth of literature shows changes in behavior and cognition following tDCS administration, the underlying neuronal mechanisms remain largely unknown. Neuroimaging studies have generally used fMRI and shown only limited consensus to date, while the few electrophysiological studies have reported mostly null or counterintuitive findings...
December 7, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28011391/pathophysiology-of-status-epilepticus
#12
REVIEW
Matthew C Walker
Status epilepticus (SE) is the maximal expression of epilepsy with a high morbidity and mortality. It occurs due to the failure of mechanisms that terminate seizures. Both human and animal data indicate that the longer a seizure lasts, the less likely it is to stop. Recent evidence suggests that there is a critical transition from an ictal to a post-ictal state, associated with a transition from a spatio-temporally desynchronized state to a highly synchronized state, respectively. As SE continues, it becomes progressively resistant to drugs, in particular benzodiazepines due partly to NMDA receptor-dependent internalization of GABA(A) receptors...
December 20, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28003411/dorsal-versus-ventral-differences-in-fast-up-state-associated-oscillations-in-the-medial-prefrontal-cortex-mpfc-of-the-urethane-anaesthetised-rat
#13
Sabine Gretenkord, Adrian Rees, Miles A Whittington, Sarah E Gartside, Fiona E N LeBeau
Cortical slow oscillations (0.1 - 1 Hz), which may play a role in memory consolidation, are a hallmark of non-rapid eye movement (NREM) sleep and also occur under anaesthesia. During slow oscillations the neuronal network generates faster oscillations on the active Up-states and these nested oscillations are particularly prominent in the PFC. In rodents the mPFC consists of several subregions: anterior cingulate cortex (ACC), prelimbic (PrL), infralimbic (IL) and dorsal peduncular cortices (DP). Although each region has a distinct anatomy and function, it is not known whether slow or fast network oscillations differ between subregions in vivo...
December 21, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28003407/muscarinic-acetylcholine-receptors-control-baseline-activity-and-hebbian-stimulus-timing-dependent-plasticity-in-fusiform-cells-of-the-dorsal-cochlear-nucleus
#14
Roxana A Stefanescu, Susan E Shore
Cholinergic modulation contributes to adaptive sensory processing by controlling spontaneous and stimulus-evoked neural activity and long term synaptic plasticity. In the dorsal cochlear nucleus, in vitro activation of muscarinic acetylcholine receptors (mAChRs) alters the spontaneous activity of DCN neurons and interacts with NMDA (N-methyl-D-aspartate) and endocannabinoid receptors to modulate the plasticity of parallel fiber synapses onto fusiform cells by converting Hebbian LTP to anti-Hebbian LTD. Because noise exposure and tinnitus are known to increase spontaneous activity in fusiform cells as well as alter stimulus-timing dependent plasticity (StTDP), it is important to understand the contribution of mAChRs to in vivo spontaneous activity and plasticity in fusiform cells...
December 21, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28000256/reliability-of-graph-metrics-derived-from-resting-state-human-eeg
#15
Karl Kuntzelman, Vladimir Miskovic
It is increasingly appreciated that a complete description of brain functioning will necessarily involve the characterization of large-scale interregional temporal synchronization of neuronal assemblies. The need to capture the dynamic formation of such large-scale networks has yielded a renewed interest in the human EEG in combination with a suite of methods for estimating functional connectivity along with the graph theoretical approaches for characterizing network structure. While initial work has established generally good reproducibility for a limited selection of these graph theoretical measures, there remains an obvious need to document the reproducibility of a more extensive array of commonly used graph metrics...
January 2017: Psychophysiology
https://www.readbyqxmd.com/read/27999185/early-and-progressive-deficit-of-neuronal-activity-patterns-in-a-model-of-local-amyloid-pathology-in-mouse-prefrontal-cortex
#16
Fani Koukouli, Marie Rooy, Uwe Maskos
Alzheimer's Disease (AD) is the most common form of dementia. The condition predominantly affects the cerebral cortex and hippocampus and is characterized by the spread of amyloid plaques and neurofibrillary tangles (NFTs). But soluble amyloid-β (Aβ) oligomers have also been identified to accumulate in the brains of AD patients and correlate with cognitive dysfunction more than the extent of plaque deposition. Here, we developed an adeno-associated viral vector expressing the human mutated amyloid precursor protein (AAV-hAPP)...
December 20, 2016: Aging
https://www.readbyqxmd.com/read/27993673/propofol-attenuates-low-frequency-fluctuations-of-resting-state-fmri-bold-signal-in-the-anterior-frontal-cortex-upon-loss-of-consciousness
#17
Xiaolin Liu, Kathryn K Lauer, B Douglas Ward, Christopher Roberts, Suyan Liu, Suneeta Gollapudy, Robert Rohloff, William Gross, Guangyu Chen, Zhan Xu, Jeffrey R Binder, Shi-Jiang Li, Anthony G Hudetz
Recent studies indicate that spontaneous low-frequency fluctuations (LFFs) of resting-state functional magnetic resonance imaging (rs-fMRI) blood oxygen level-dependent (BOLD) signals are driven by the slow (<0.1Hz) modulation of ongoing neuronal activity synchronized locally and across remote brain regions. How regional LFFs of the BOLD fMRI signal are altered during anesthetic-induced alteration of consciousness is not well understood. Using rs-fMRI in 15 healthy participants, we show that during administration of propofol to achieve loss of behavioral responsiveness indexing unconsciousness, the fractional amplitude of LFF (fALFF index) was reduced in comparison to wakeful baseline in the anterior frontal regions, temporal pole, hippocampus, parahippocampal gyrus, and amygdala...
December 16, 2016: NeuroImage
https://www.readbyqxmd.com/read/27990109/timing-intervals-using-population-synchrony-and-spike-timing-dependent-plasticity
#18
Wei Xu, Stuart N Baker
We present a computational model by which ensembles of regularly spiking neurons can encode different time intervals through synchronous firing. We show that a neuron responding to a large population of convergent inputs has the potential to learn to produce an appropriately-timed output via spike-time dependent plasticity. We explain why temporal variability of this population synchrony increases with increasing time intervals. We also show that the scalar property of timing and its violation at short intervals can be explained by the spike-wise accumulation of jitter in the inter-spike intervals of timing neurons...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27990034/a-dynamic-bayesian-model-for-characterizing-cross-neuronal-interactions-during-decision-making
#19
Bo Zhou, David E Moorman, Sam Behseta, Hernando Ombao, Babak Shahbaba
The goal of this paper is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision making. For an individual to successfully complete the task of decision-making, a number of temporally-organized events must occur: stimuli must be detected, potential outcomes must be evaluated, behaviors must be executed or inhibited, and outcomes (such as reward or no-reward) must be experienced. Due to the complexity of this process, it is likely the case that decision-making is encoded by the temporally-precise interactions between large populations of neurons...
2016: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/27989462/bidirectional-control-of-generalized-epilepsy-networks-via-rapid-real-time-switching-of-firing-mode
#20
Jordan M Sorokin, Thomas J Davidson, Eric Frechette, Armen M Abramian, Karl Deisseroth, John R Huguenard, Jeanne T Paz
Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic spiking. Studies in brain slices have led to a model in which rhythmic synchronized spiking (phasic firing) in a population of relay neurons leads to hyper-synchronous oscillatory cortico-thalamo-cortical rhythms that result in absence seizures. This model suggests that blocking thalamocortical phasic firing would treat absence seizures. However, recent in vivo studies in anesthetized animals have questioned this simple model...
January 4, 2017: Neuron
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