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https://www.readbyqxmd.com/read/29235400/role-of-bevacizumab-in-the-management-of-the-patient-with-malignant-pleural-effusion-more-questions-than-answers
#1
Ralph Llewel Sabang, Deepthi Gandhiraj, Michael Fanucchi, Oleg Epelbaum
Malignant pleural effusion (MPE) is a feature of metastatic cancer that is associated with significant morbidity and healthcare costs. The typical current management of MPE involves the combination of systemic chemotherapy and mechanical intervention in the pleural space. Vascular endothelial growth factor (VEGF), an extremely potent inducer of vascular permeability, has been shown to mediate fluid formation in pleural malignancy. Therefore, bevacizumab, an inhibitor of VEGF activity, offers theoretical promise as a means of abolishing fluid formation in MPE...
December 13, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29233386/a-national-survey-on-the-current-status-of-informatics-residency-education-in-pharmacy
#2
Anthony Blash, Connie L Saltsman, Condit Steil
BACKGROUND AND PURPOSE: Upon completion of their post-graduate training, pharmacy informatics residents need to be prepared to interact with clinical and technology experts in the new healthcare environment. This study describes pharmacy informatics residency programs within the United States. EDUCATIONAL ACTIVITY AND SETTING: Preliminary information for all pharmacy informatics residency programs was accessed from program webpages. An email was sent out to programs asking them to respond to a six-item questionnaire...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233300/pharmacy-informatics-a-call-to-action-for-educators-administrators-and-residency-directors
#3
Taylor J Steckler, Michael J Brownlee, Benjamin Y Urick, Matthew J Farley
Pharmacy informatics involves the customization and application of information technology to improve medication-related processes. It is a critical function given the recent expansion of technology and prevalence of medication use throughout healthcare. Despite the necessity for pharmacy involvement, many pharmacists and student pharmacists are unaware of how to get started in informatics. Ideally, training should start early with student pharmacists being enrolled in introductory courses taught by leaders in the field...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233280/implementation-of-a-longitudinal-early-immersion-student-pharmacist-health-system-internship-program
#4
Lindsey B Amerine, John M Valgus, Joseph D Moore, Justin R Arnall, Scott W Savage
PURPOSE: The initiation, implementation, and benefits of a longitudinal early immersion student pharmacist health system internship are described. EDUCATIONAL ACTIVITY: A two-year longitudinal internship experience was implemented to provide exposure into distributional operations, direct patient care activities, and health-system pharmacy administration. The intent of the program was to create an opportunity for student pharmacists to enhance the quality of their education with practical experience by immersing them early in their careers within the healthcare system...
May 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233172/the-effects-of-austerity-measures-on-quality-of-healthcare-services-a-national-survey-of-physicians-in-the-public-and-private-sectors-in-portugal
#5
Tiago Correia, Graça Carapinheiro, Helena Carvalho, José Manuel Silva, Gilles Dussault
BACKGROUND: The European Union member countries reacted differently to the 2008 economic and financial crisis. However, few countries have monitored the outcomes of their policy responses, and there is therefore little evidence as to whether or not savings undermined the performance of health systems. We discuss the situation in Portugal, where a financial adjustment program was implemented between 2011 and 2014, and explore the views of health workers on the effects of austerity measures on quality of care delivery...
December 12, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/29232913/pharmacoeconomic-analysis-of-drugs-used-in-the-treatment-of-pneumonia-in-paediatric-population-in-a-tertiary-care-hospital-in-india-a-cost-of-illness-study
#6
Lekha Saha, Sharonjeet Kaur, Pratibha Khosla, Sweta Kumari, Alka Rani
AIMS AND OBJECTIVES: The cost of antibiotic therapy for the treatment of pneumonia in the inpatient paediatric population can have a major impact on the healthcare expenditure. We planned to assess the direct and indirect costs of diagnosis and medical treatment of paediatric patients with community acquired pneumonia who are hospitalized in a tertiary care hospital in India. METHODS: 125 children with a diagnosis of pneumonia who were admitted to the inpatient department of a paediatric hospital receiving antibiotic treatment were observed...
December 11, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29232365/monitoring-compliance-with-standards-of-care-for-chronic-diseases-using-healthcare-administrative-databases-in-italy-strengths-and-limitations
#7
Rosa Gini, Martijn J Schuemie, Alessandro Pasqua, Emanuele Carlini, Francesco Profili, Iacopo Cricelli, Patrizio Dazzi, Valentina Barletta, Paolo Francesconi, Francesco Lapi, Andrea Donatini, Giulia Dal Co, Modesta Visca, Mariadonata Bellentani, Miriam Sturkenboom, Niek Klazinga
BACKGROUND: A recent comprehensive report on healthcare quality in Italy published by the Organization of Economic Co-operation and Development (OECD) recommended that regular monitoring of quality of primary care by means of compliance with standards of care for chronic diseases is performed. A previous ecological study demonstrated that compliance with standards of care could be reliably estimated on regional level using administrative databases. This study compares estimates based on administrative data with estimates based on GP records for the same persons, to understand whether ecological fallacy played a role in the results of the previous study...
2017: PloS One
https://www.readbyqxmd.com/read/29230800/negotiating-quality-standards-for-effective-delivery-of-labor-and-childbirth-care-in-nigeria-and-uganda
#8
Olufemi T Oladapo, Meghan A Bohren, Bukola Fawole, Kidza Mugerwa, Olubunmi A Ojelade, Musibau A Titiloye, Francis E Alu, Musana O Mambya, Lawal Oyeneyin, Salim Bataale, Adesina Akintan, Olubunmi Alabi, Amos Adebayo, Ola Okike, Hadiza A Idris, Sanni Wilfred, Halima Bello, David Kyaddondo, Akinpelu O Olutayo, Josaphat Byamugisha, Joao Paulo Souza, A Metin Gülmezoglu
OBJECTIVE: "Negotiated standards" describe a level of quality of care that is acceptable and achievable within a specific health system, based on consensus between key stakeholders. This paper presents the development of negotiated standards for effective labor and childbirth care in selected hospitals and communities in Nigeria and Uganda. METHODS: A four-step development process involving different methodologies. The process included: (1) review and synthesis of internationally recognized intrapartum clinical principles and practices; (2) primary qualitative research to assess values and preferences of women and healthcare providers, and practices that align with these preferences; (3) draft contextualization of effective and ineffective behaviors to reflect values and preferences; and (4) WHO-mediated negotiations between relevant stakeholders, including community members, providers, and administrators...
December 12, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29228927/treatment-with-botulinum-toxin-a-in-a-total-population-of-children-with-cerebral-palsy-a-retrospective-cohort-registry-study
#9
Maria Franzén, Gunnar Hägglund, Ann Alriksson-Schmidt
BACKGROUND: Botulinum toxin A (BTX-A) has been used to reduce spasticity in children with cerebral palsy (CP) for decades. The purpose of this study was to analyze to what extent BTX-A treatment was used to treat spasticity in a total population of children with CP. We investigated 1) the use of BTX-A in relation to age, sex, and Gross Motor Function Classification System (GMFCS) level, 2) the most common muscle groups treated with BTX-A in relation to the same variables, and 3) changes in the proportions of children treated with BTX-A between two time points (2010 and 2015)...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29228295/assessment-of-patient-safety-culture-in-private-and-public-hospitals-in-peru
#10
Alejandro Arrieta, Gabriela Suárez, Galed Hakim
Objective: To assess the patient safety culture in Peruvian hospitals from the perspective of healthcare professionals, and to test for differences between the private and public healthcare sectors. Patient safety is defined as the avoidance and prevention of patient injuries or adverse events resulting from the processes of healthcare delivery. Design: A non-random cross-sectional study conducted online. Setting: An online survey was administered from July to August 2016, in Peru...
December 8, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29227855/a-case-report-of-successful-management-of-clostridium-difficile-colitis-with-antegrade-fidaxomicin-through-a-mucous-fistula-obviating-the-need-for-subtotal-colectomy
#11
Suzanne Arnott, Matthew Skancke, Sheena Chen, Bruce Abell
INTRODUCTION: Clostridium difficile is the most common cause of healthcare-associated infections and can have devastating morbidity and mortality. Traditional treatment algorithms involve intravenous metronidazole and enteric metronidazole or vancomycin. Fidaxomicin (DificidR) targets "switch regions" within RNA polymerases and effectively kills clostridium difficile bacteria and is typically administered orally primarily or through a naso/oro-gastric conduit. PRESENTATION OF CASE: 55-year-old with a recent elective surgical procedure was hospitalized with multifocal pneumonia and subsequently developed clostridium difficile colitis...
November 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227352/epidemiology-of-axial-spondyloarthritis-an-update
#12
Runsheng Wang, Michael M Ward
PURPOSE OF REVIEW: To provide an update of the prevalence and incidence of axial spondyloarthritis in the general population and in patients with spondyloarthritis-related conditions, environmental risk factors for ankylosing spondylitis, progression from nonradiographic axial spondyloarthritis to ankylosing spondylitis, mortality, and risks for cardiovascular events in patients with ankylosing spondylitis. RECENT FINDINGS: Increasingly, administrative healthcare data have been used to study disease frequency and outcomes...
December 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29226070/economic-burden-of-community-acquired-pneumonia-among-elderly-patients-a-japanese-perspective
#13
Keiko Konomura, Hideaki Nagai, Manabu Akazawa
Background: This study aimed to estimate the economic burden of community-acquired pneumonia (CAP) among elderly patients in Japan. In addition, the study evaluated the relationship between total treatment cost and CAP risk factors. Methods: An administrative database was searched for elderly patients (≥ 65 years old) who had pneumonia (ICD-10 code: J12-J18) and an antibiotic prescription between 1 June 2014 and 31 May 2015. The all-cause total healthcare costs of outpatient and inpatient CAP episodes were calculated...
2017: Pneumonia
https://www.readbyqxmd.com/read/29223983/ensuring-patient-safety-and-access-in-cancer-care
#14
Katy Winckworth-Prejsnar, Elizabeth A Nardi, James McCanney, F Marc Stewart, Terry Langbaum, Bruce J Gould, C Lyn Fitzgerald, Robert W Carlson
The inability to obtain the right high-quality cancer care in a timely and safe manner can have devastating results for patients. As cancer care becomes inundated with cutting edge and novel treatments, such as personalized medicine, oral chemotherapy, biosimilars, and immunotherapy, new safety challenges are emerging at increasing speed and complexity. Moreover, shifting federal healthcare policies could have significant implications for the safety and access to high-quality and effective cancer care for millions of patients with cancer...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223870/validation-of-an-algorithm-to-detect-severe-ms-relapses-in-administrative-health-databases
#15
James John Marriott, Hui Chen, Randall Fransoo, Ruth Ann Marrie
BACKGROUND: Severe relapses that required treatment were important outcomes in the sentinel trials of disease-modifying therapy (DMT). Identifying such relapses in administrative data would allow comparative-effectiveness studies of DMTs to be conducted in real-world clinical settings. METHODS: All relapsing-remitting (RRMS) and secondary-progressive (SPMS) patients living in Manitoba between 1999 and 2015 were identified using a validated case definition and linkage to the Manitoba MS Clinic database...
December 2, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29223428/enabling-social-listening-for-cardiac-safety-monitoring-proceedings-from-a-drug-information-association-cardiac-safety-research-consortium-cosponsored-think-tank
#16
REVIEW
Harry A Seifert, Raleigh E Malik, Mondira Bhattacharya, Kevin R Campbell, Sally Okun, Carrie Pierce, Jeffrey Terkowitz, J Rick Turner, Mitchell W Krucoff, Gregory E Powell
This white paper provides a summary of the presentations and discussions from a think tank on "Enabling Social Listening for Cardiac Safety Monitoring" trials that was cosponsored by the Drug Information Association and the Cardiac Safety Research Consortium, and held at the White Oak headquarters of the US Food and Drug Administration on June 3, 2016. The meeting's goals were to explore current methods of collecting and evaluating social listening data and to consider their applicability to cardiac safety surveillance...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29219908/characteristics-of-the-nursing-practice-environment-associated-with-lower-unit-level-rn-turnover
#17
Heather V Nelson-Brantley, Shin Hye Park, Sandra Bergquist-Beringer
OBJECTIVE: The aim of this study is to examine characteristics of the nursing practice environment associated with lower RN turnover. BACKGROUND: Identifying characteristics of the practice environment that contribute to lower RN turnover is important for meeting the national quality strategy priority of reducing healthcare costs. METHODS: Data from 1002 adult care units in 162 National Database of Nursing Quality Indicators participating hospitals were analyzed using multivariate linear regression...
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219901/shifting-the-paradigm-educating-nurse-administrators-to-be-full-partners
#18
Teddie Potter
In this month's CGEAN column, leaders discuss the current complexities of healthcare requiring nurses to practice competently in interprofessional partnerships. Nurse administrators and executives play a key role in leading culture change so the benefits of full partnership are realized.
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29218726/healthcare-providers-perspectives-on-labor-monitoring-in-nigeria-and-uganda-a-qualitative-study-on-challenges-and-opportunities
#19
Fan Yang, Meghan A Bohren, David Kyaddondo, Musibau A Titiloye, Akinpelu O Olutayo, Olufemi T Oladapo, João Paulo Souza, A Metin Gülmezoglu, Kidza Mugerwa, Bukola Fawole
OBJECTIVE: To explore current practices, challenges, and opportunities in relation to monitoring labor progression, from the perspectives of healthcare professionals in low-resource settings. METHODS: Thematic analysis of qualitative data (in-depth interviews [IDIs] and focus group discussions [FDGs]) obtained from a purposive sample of healthcare providers and managers in selected health facilities in Nigeria and Uganda. RESULTS: A total of 70 IDIs and 16 FGDs with doctors, midwives, and administrators are included in this analysis...
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29218719/the-communication-and-emotional-support-needs-to-improve-women-s-experience-of-childbirth-care-in-health-facilities-in-southwest-nigeria-a-qualitative-study
#20
Olubunmi A Ojelade, Musibau A Titiloye, Meghan A Bohren, Akinpelu O Olutayo, Adebimpe A Olalere, Adesina Akintan, Olufemi T Oladapo, Bukola Fawole
OBJECTIVE: To improve women's childbirth experiences in health facilities, their psychosocial and communication needs have to be met. However, what constitutes these specific needs is poorly understood, particularly in Sub-Saharan Africa. This paper explores women's needs for communication and emotional support during facility-based childbirth. METHODS: Qualitative research was conducted in a large referral maternity hospital and its catchment communities in Akure, Nigeria...
December 8, 2017: International Journal of Gynaecology and Obstetrics
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