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https://www.readbyqxmd.com/read/28655169/hospital-at-home-integrated-care-programme-for-the-management-of-disabling-health-crises-in-older-patients-comparison-with-bed-based-intermediate-care
#1
Miquel À Mas, Marco Inzitari, Sergi Sabaté, Sebastià J Santaeugènia, Ramón Miralles
Objective: to analyse the clinical impact of a home-based Intermediate Care model in the Catalan health system, comparing it with usual bed-based care. Design: quasi-experimental longitudinal study. Setting: hospital Municipal de Badalona and El Carme Intermediate Care Hospital, Badalona, Catalonia, Spain. Participants: we included older patients with medical and orthopaedic disabling health crises in need of Comprehensive Geriatric Assessment (CGA) and rehabilitation...
June 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28655092/-evaluation-of-clinical-characteristics-myd88-l265p-mutation-cxcr4-whim-mutation-and-prognosis-in-waldenstr%C3%A3-m-macroglobulinemia-a-single-center-retrospective-study-of-93-patients
#2
X X Cao, Q Meng, H Cai, Y Y Mao, M H Duan, T N Zhu, W Zhang, B Han, J L Zhuang, H C Cai, M Chen, J Feng, X Han, Y Zhang, C Yang, L Zhang, D B Zhou, J Li
Objective: To evaluate the clinical characteristics, MYD88(L265P) mutation, CXCR4(W)HIM mutation and prognosis in patients with Waldenström macroglobulinemia (WM). Methods: The clinical characteristics, International Prognostic Scoring System for symptomatic WM (WPSS) , and overall survival (OS) were retrospectively assayed in 93 patients with newly diagnosed WM at Peking Union Medical College Hospital during January 2000 to August 2016. The MYD88(L265P) mutation and CXCR4(W)HIM mutation were tested among 34 patients...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28655082/-impact-of-the-2016-new-definition-and-classification-system-of-pancreatic-fistula-on-the-evaluation-of-pancreatic-fistula-after-pancreatic-surgery
#3
X L Han, J Xu, W M Wu, M H Dai, T P Zhang, Q Liao, G Chen, J C Guo, W B Wang, L Cong, Y P Zhao
Objective: To discuss the impact of updated definition and classification system of pancreatic fistula published in 2016 on the postoperative classification of pancreatic fistula. Methods: Retrospective analysis was made on patients who underwent pancreatic surgery at ward 1 in Department of General Surgery, Peking Union Medical College Hospital from January 2015 to December 2016.A total of 408 patients were included in this retrospective study, male/female was 184/224, aged from 9 to 81 years with mean age of 51...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28655067/fatal-ulcerative-enteritis-of-the-small-intestine-in-a-patient-with-ulcerative-colitis-treated-with-vedolizumab
#4
Carmen Monasterio, Annette Schmitt-Gräff, Matthias Pohl, Thomas Truschel, Klaus Warnatz, Wolfgang Kreisel, Robert Thimme, Peter Hasselblatt
Vedolizumab (VDZ) inhibits α4β7 integrins and is used to target intestinal immune responses in patients with inflammatory bowel disease, which is considered to be relatively safe. Here we report on a fatal complication following VDZ administration. A 64-year-old female patient with ulcerative colitis (UC) refractory to tumor necrosis factor inhibitors was treated with VDZ. One week after the second VDZ infusion, she was admitted to hospital with severe diarrhea and systemic inflammatory response syndrome (SIRS)...
June 27, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28655032/age-related-macular-degeneration-in-patients-with-chronic-myeloproliferative-neoplasms
#5
Marie Bak, Torben Lykke Sørensen, Esben Meulengracht Flachs, Ann-Dorthe Zwisler, Knud Juel, Henrik Frederiksen, Hans Carl Hasselbalch
Importance: It has been suggested that systemic inflammation increases the risk of age-related macular degeneration (AMD). Given that chronic immune modulation is present in patients with myeloproliferative neoplasms (MPNs), the risk of AMD in these patients may be increased. Objective: To compare the risk of AMD in patients with MPNs with the risk of AMD in matched controls from the general population. Design, Setting, and Participants: A nationwide population-based cohort study using Danish registers was conducted of all patients in Denmark who received a diagnosis between January 1, 1994, and December 31, 2013, of essential thrombocythemia, polycythemia vera, myelofibrosis, or unclassifiable MPNs...
June 22, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28654972/effect-of-electronic-reminders-financial-incentives-and-social-support-on-outcomes-after-myocardial-infarction-the-heartstrong-randomized-clinical-trial
#6
Kevin G Volpp, Andrea B Troxel, Shivan J Mehta, Laurie Norton, Jingsan Zhu, Raymond Lim, Wenli Wang, Noora Marcus, Christian Terwiesch, Kristen Caldarella, Tova Levin, Mike Relish, Nathan Negin, Aaron Smith-McLallen, Richard Snyder, Claire M Spettell, Brian Drachman, Daniel Kolansky, David A Asch
Importance: Adherence to medications prescribed after acute myocardial infarction (AMI) is low. Wireless technology and behavioral economic approaches have shown promise in improving health behaviors. Objective: To determine whether a system of medication reminders using financial incentives and social support delays subsequent vascular events in patients following AMI compared with usual care. Design, Setting, and Participants: Two-arm, randomized clinical trial with a 12-month intervention conducted from 2013 through 2016...
June 26, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28654765/a-traffic-light-grading-system-of-hip-dysplasia-to-predict-the-success-of-arthroscopic-hip-surgery
#7
George Grammatopoulos, Owain L I Davies, Ahmed El-Bakoury, Harinderjit S Gill, Tom C B Pollard, Antonio J Andrade
BACKGROUND: The role of hip arthroscopic surgery in dysplasia is controversial. PURPOSE: To determine the 7-year joint preservation rate after hip arthroscopic surgery in hip dysplasia and identify anatomic and intraoperative features that predict the success of hip preservation with arthroscopic surgery, allowing the formulation of an evidence-based classification system. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Between 2008 and 2013, 111 hips with dysplastic features (acetabular index [AI] >10° and/or lateral center-edge angle [LCEA] <25°) that underwent arthroscopic surgery were identified...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28654692/heart-rate-variability-as-predictor-of-mortality-in-sepsis-a-prospective-cohort-study
#8
Fábio M de Castilho, Antonio Luiz P Ribeiro, José Luiz P da Silva, Vandack Nobre, Marcos R de Sousa
BACKGROUND: Sepsis is a serious medical condition with increasing prevalence and high mortality. The role of the autonomic nervous system in pathophysiology of sepsis has been increasingly researched. The objective of this study is to evaluate the Heart rate variability (HRV) as a predictor of mortality in septic patients. METHODS: This was a prospective cohort of patients diagnosed with sepsis. Patient recruitment was carried out at ICU in tertiary university hospital between March 2012 and February 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28654675/estimating-the-disease-burden-of-methicillin-resistant-staphylococcus-aureus-in-japan-retrospective-database-study-of-japanese-hospitals
#9
Hironori Uematsu, Kazuto Yamashita, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
OBJECTIVES: The nationwide impact of antimicrobial-resistant infections on healthcare facilities throughout Japan has yet to be examined. This study aimed to estimate the disease burden of methicillin-resistant Staphylococcus aureus (MRSA) infections in Japanese hospitals. DESIGN: Retrospective analysis of inpatients comparing outcomes between subjects with and without MRSA infection. DATA SOURCE: A nationwide administrative claims database...
2017: PloS One
https://www.readbyqxmd.com/read/28654543/extended-versus-narrow-spectrum-antibiotics-in-the-management-of-uncomplicated-appendicitis-in-children-a-propensity-matched-comparative-effectiveness-study
#10
Danielle B Cameron, Patrice Melvin, Dionne A Graham, Charity C Glass, Stephanie K Serres, Matthew P Kronman, Jacqueline M Saito, Shawn J Rangel
OBJECTIVE: The aim of this study was to compare the effectiveness of extended versus narrow spectrum antibiotics in preventing surgical site infections (SSIs) and hospital revisits in children with uncomplicated appendicitis. SUMMARY OF BACKGROUND DATA: There is a paucity of high-quality evidence in the pediatric literature comparing the effectiveness of extended versus narrow-spectrum antibiotics in the prevention of SSIs associated with uncomplicated appendicitis...
June 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28654441/multidisciplinary-assessment-of-100-athletes-with-groin-pain-using-the-doha-agreement-high-prevalence-of-adductor-related-groin-pain-in-conjunction-with-multiple-causes
#11
Rachel Taylor, Zarko Vuckovic, Andrea Mosler, Rintje Agricola, Roald Otten, Philipp Jacobsen, Per Holmich, Adam Weir
OBJECTIVE: To examine the prevalence of different causes of groin pain in athletes using the recent Doha consensus classification of terminology and definitions of groin pain in athletes. DESIGN: Descriptive epidemiological study. SETTING: Multidisciplinary sports groin pain clinic at Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar. PATIENTS: The clinical records of 100 consecutive athletes with complaints of groin pain who attended the multidisciplinary sports groin pain clinic between January and December 2014 were analyzed...
June 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28654005/an-integrated-approach-for-the-environmental-characterization-of-a-wide-potentially-contaminated-area-in-southern-italy
#12
Daniela Ducci, Stefano Albanese, Lorenzo Boccia, Egidio Celentano, Elena Cervelli, Alfonso Corniello, Anna Crispo, Benedetto De Vivo, Paolo Iodice, Carmela Langella, Annamaria Lima, Maurizio Manno, Mario Palladino, Stefania Pindozzi, Marina Rigillo, Nunzio Romano, Mariangela Sellerino, Adolfo Senatore, Giuseppe Speranza, Nunzio Fiorentino, Massimo Fagnano
This paper deals with the environmental characterization of a large and densely populated area, with a poor reputation for contamination, considering the contribution of environmental features (air, soil, soil hydraulic and groundwater) and the potential effects on human health. The use of Geographic Information System (GIS) has made possible a georeferenced inventory and, by overlaying environmental information, an operational synthesis of comprehensive environmental conditions. The cumulative effects on environmental features were evaluated, taking into account superposition effects, by means of the Spatial MultiCriteria Decision Analysis (S-MCDA)...
June 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28653945/microbiological-outcomes-and-antibiotic-overuse-in-emergency-department-patients-with-suspected-sepsis
#13
T C Minderhoud, C Spruyt, S Huisman, E Oskam, S C E Schuit, M D Levin
OBJECTIVE: To study the presence of bacterial disease and antibiotic use in patients in the emergency department (ED) included in the local sepsis protocol. METHODS: An observational retrospective cohort study. Adults aged > 18 years, presenting to the ED of a large teaching hospital, from 1 January to 1 June 2011, with more than two SIRS criteria and a clinical suspicion of sepsis were included. RESULTS: Bacterial disease was suspected or confirmed in only 71% of all the patients with suspected sepsis (2008 definition) and consequently treated with antibiotics...
June 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28653876/nuclear-ubiquitin-c-terminal-hydrolase-l5-expression-associates-with-increased-patient-survival-in-pancreatic-ductal-adenocarcinoma
#14
Leena Arpalahti, Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Carina I Holmberg
Pancreatic ductal adenocarcinoma is a lethal disease with an overall 5-year survival of less than 5%. Prognosis among surgically treated patients is difficult and identification of new biomarkers is essential for accurate prediction of patient outcome. As part of one of the major cellular protein degradation systems, the proteasome plays a fundamental role in both physiological and pathophysiological conditions including cancer. The proteasome-associated deubiquitinating enzyme ubiquitin C-terminal hydrolase L5 (UCHL5)/Uch37 is a modulator of proteasome activity with cancer prognostic marker potential...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653787/antibacterial-resistance-and-the-success-of-tailored-triple-therapy-in-helicobacter-pylori-strains-isolated-from-slovenian-children
#15
Tita Butenko, Samo Jeverica, Rok Orel, Matjaž Homan
BACKGROUND: Primary Helicobacter pylori (H. pylori) infection occurs predominantly in childhood. Antimicrobial resistance is the leading cause for H. pylori eradication failure. The aims of this study were (i) to establish for the first time the antimicrobial resistance of H. pylori strains in infected Slovenian children not previously treated for H. pylori infection and (ii) to evaluate the effectiveness of tailored triple therapy, assuming that eradication rate with tailored triple therapy will be >90%...
June 27, 2017: Helicobacter
https://www.readbyqxmd.com/read/28653562/mcgill-thyroid-nodule-score-in-differentiating-benign-and-malignant-pediatric-thyroid-nodules-a-pilot-study
#16
Michael Canfarotta, Douglas Moote, Christine Finck, Rebecca Riba-Wolman, Shefali Thaker, Trudy J Lerer, Richard J Payne, Valerie Cote
Objective The McGill Thyroid Nodule Score (MTNS) is a preoperative tool used to predict the risk for well-differentiated thyroid cancer given a specific nodule in adults. We evaluated the clinical utility of a modified pediatric MTNS with children and adolescents. Study Design Case series with chart review. Setting Tertiary care children's hospital. Subjects and Methods This is a retrospective chart review of 46 patients ≤18 years of age presenting with a solitary or dominant thyroid nodule treated with surgical resection between September 2008 and December 2015...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28653347/preliminary-evaluation-of-pleurotus-ostreatus-for-the-removal-of-selected-pharmaceuticals-from-hospital-wastewater
#17
Laura Palli, Francesc Castellet-Rovira, Miriam Pérez-Trujillo, Donatella Caniani, Montserrat Sarrà-Adroguer, Riccardo Gori
The fungus Pleurotus ostreatus was investigated to assess its ability to remove diclofenac, ketoprofen and atenolol spiked at 10 mg/L each one in hospital wastewater. The degradation test was carried out in a fluidized bed bioreactor testing both the batch and the continuous mode (hydraulic retention time in the range 1.63-3 d). In batch mode, diclofenac disappeared in less than 24 h, ketoprofen was degraded up to almost 50% in 5 d while atenolol was not removed. In continuous mode, diclofenac and ketoprofen removals were about 100% and 70% respectively; atenolol degradation was negligible during the first 20 d but it increased up to 60% after a peak of laccase production and notable biomass growth...
June 27, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28653327/are-severely-injured-trauma-victims-in-norway-offered-advanced-pre-hospital-care-national-retrospective-observational-cohort
#18
T Wisborg, E N Ellensen, I Svege, T Dehli
BACKGROUND: Studies of severely injured patients suggest that advanced pre-hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the greatest need. Norway has 19 Emergency Helicopters (HEMS) staffed by anaesthesiologists on duty 24/7/365. National regulations describe indications for their use, and the use of the national emergency medical dispatch guideline is recommended. We assessed whether severely injured patients had been treated or transported by advanced resources on a national scale...
June 26, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28653264/survival-analysis-of-patients-with-systemic-lupus-erythematosus-in-a-tertiary-hospital-in-southern-brazil
#19
Jordana Vaz Hendler, Lucian de Souza, Daniele Corrêa de Freitas Zernow, Juliano Guimarães, Thiago Bertotto, Carla Forgiarini Saldanha, João Carlos Tavares Brenol, Odirlei André Monticielo
Systemic lupus erythematosus (SLE) treatments progress over the years. However, the mortality remains higher than in the general population. Few studies have examined SLE patients' survival in Brazil. This study aims to identify the main characteristics and risk factors to predict mortality and recognize the main causes of death in Brazilian patients with SLE. We retrospectively assessed clinical, demographic, and serological characteristics from 600 patients followed since 2001 in SLE outpatient clinic from Hospital de Clínicas de Porto Alegre...
June 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28652957/a-retrospective-study-of-acute-renal-failure-in-children-its-incidence-etiology-complications-and-prognosis
#20
Kadar Ismail Hassan, Jama Hodan M, Chunfu Li
BACKGROUND: Acute renal failure (ARF) developed due to various causes and may lead to significant morbidity and mortality among pediatric patients. OBJECTIVES: The study was conducted to determine the incidence, etiology, outcome of treatment and clinical presentation of ARF in pediatric patients in Somalia. METHODS: Comprehensive case history of 39 pediatric patients below 12 years of age, admitted with renal diseases in four tertiary care hospitals in Hargeisa and Borama cities in Somalia during December 2015 to November 2016...
May 25, 2017: Curēus
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