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https://www.readbyqxmd.com/read/29050884/initial-digital-vasculitis-in-a-large-multicenter-cohort-of-childhood-onset-systemic-lupus-erythematosus
#1
Ana Paula Sakamoto, Clovis Artur Silva, Marco Felipe Castro da Silva, Anandreia Simões Lopes, Gleice Clemente Souza Russo, Adriana Maluf Elias Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa Maria Rodrigues Pereira, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population. METHODS: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil. RESULTS: DV was observed in 25/852 (3%) cSLE patients. Periungual hemorrhage was diagnosed in 12 (48%), periungual infarction in 7 (28%), tip finger ulceration in 4 (16%), painful nodules in 1 (4%) and gangrene in 1 (4%)...
October 16, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29050537/hospitalizations-among-danish-sle-patients-a-prospective-study-on-incidence-causes-of-admission-and-risk-factors-in-a-population-based-cohort
#2
R W Busch, S D Kay, A Voss
Objective To determine the incidence, duration and cause of hospitalization in a cohort of Danish patients with systemic lupus erythematosus (SLE). In addition, we investigated risk factors for admission and prolonged hospital stay. Methods A total of 155 SLE patients from a population-based cohort were included in the study during a period of 70 months, from January 2007 to October 2012. Data on frequency, cause and duration of hospitalizations were obtained by review of medical charts. Data on disease manifestations, organ damage and treatment were collected prospectively...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29050534/low-copy-numbers-of-complement-c4-and-homozygous-deficiency-of-c4a-may-predispose-to-severe-disease-and-earlier-disease-onset-in-patients-with-systemic-lupus-erythematosus
#3
M Jüptner, F Flachsbart, A Caliebe, W Lieb, S Schreiber, R Zeuner, A Franke, J O Schröder
Objectives Low copy numbers and deletion of complement C4 genes are potent risk factors for systemic lupus erythematosus (SLE). However, it is not known whether this genetic association affects the clinical outcome. We investigated C4 copy number variation and its relationship to clinical and serological features in a Northern European lupus cohort. Methods We genotyped the C4 gene locus using polymerase chain reaction (PCR)-based TaqMan assays in 169 patients with SLE classified according to the 1997 revised American College of Rheumatology (ACR) criteria and in 520 matched controls...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29049933/systemic-autoimmune-diseases-are-associated-with-an-increased-risk-of-bipolar-disorder-a-nationwide-population-based-cohort-study
#4
Ling-Yi Wang, Jen-Huai Chiang, Shih-Fen Chen, Yu-Chih Shen
BACKGROUND: Studies suggested autoimmunity plays a role in the etiology of bipolar disorder (BD). This study aimed to investigate the association between systemic autoimmune diseases (SADs) and the subsequent development of BD, and examine the potential risk factors for developing BD. METHODS: Patients with SADs were identified in the Taiwan National Health Insurance Program (NHIP). A comparison cohort was created by matching patients without SADs with age. The SADs cohort consisted of 65,498 while the comparison cohort consisted of 261,992 patients...
October 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29048543/cardiac-tamponade-in-systemic-lupus-erythematosus
#5
Rudra Prosad Goswami, Geetabali Sircar, Alakendu Ghosh, Parasar Ghosh
OBJECTIVES: To describe incidence, risk factors and treatment of cardiac tamponade in a large cohort of Indian patients with systemic lupus erythematosus (SLE). METHODS: This retrospective study was conducted at the Department of Rheumatology, IPGMER, Kolkata, India from May 2014 to December 2016 on admitted patients with SLE. Lupus-related serositis was diagnosed after excluding other causes, such as infection, malignancy or heart failure. RESULTS: Of 409 patients with SLE, pericarditis was diagnosed in 25...
October 17, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29045037/autoantibodies-targeting-ficolin-2-in-systemic-lupus-erythematosus-patients-with-active-nephritis
#6
Sophie Colliard, Noémie Jourde-Chiche, Giovanna Clavarino, Françoise Sarrot-Reynauld, Evelyne Gout, Alban Deroux, Mélanie Fougere, Nathalie Bardin, Laurence Bouillet, Jean-Yves Cesbron, Nicole M Thielens, Chantal Dumestre-Pérard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease characterized by production of various autoantibodies. The aim of this study was to investigate the presence of anti-ficolin-2 antibodies in SLE patients and to evaluate the association between the levels of these autoantibodies, clinical manifestations, and disease activity. METHODS: This is a comparative study using a cohort of 165 SLE patients and 48 healthy subjects. SLE patients were further divided into two groups, with "low disease activity" (SLEDAI score ≤ 4, n = 88) and with "high disease activity" (SLEDAI score > 4, n = 77)...
October 17, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29044928/a-rare-variant-rs933717-at-fbxo31-map1lc3b-in-chinese-is-associated-with-systemic-lupus-erythematosus
#7
Yuan-Yuan Qi, Xu-Jie Zhou, Swapan K Nath, Celi Sun, Yan-Na Wang, Ping Hou, Rong Mu, Chun Li, Jian-Ping Guo, Zhan-Guo Li, Geng Wang, Hu-Ji Xu, Yan-Jie Hao, Zhuo-Li Zhang, Wei-Hua Yue, Huo-Ru Zhang, Ming-Hui Zhao, Hong Zhang
OBJECTIVE: Recent evidence from genetic, cell biology and model animal studies have suggested a pivotal role of autophagy in mediating systemic lupus erythematosus (SLE). However, the genetic basis has not yet been thoroughly examined. The aim of the present study was therefore to identify additional susceptibility variants in autophagy-related genes, and their functional significance. METHODS: First, we performed a gene family-based genetic association analysis in patients with SLE using ImmunoChip, and selected the top-associated polymorphisms for replication in additional cohorts...
October 17, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#8
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
October 18, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29032462/association-of-tnfsf4-polymorphisms-with-neuromyelitis-optica-spectrum-disorders-in-a-chinese-population
#9
Zhiyun Lian, Ju Liu, Ziyan Shi, Hongxi Chen, Qin Zhang, Huiru Feng, Qin Du, Xiaohui Miao, Hongyu Zhou
The tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene encodes a vital co-stimulatory molecule of the immune system and has been identified as a susceptibility locus for systemic lupus erythematosus, systemic sclerosis, and primary Sjögren's syndrome. However, the association of TNFSF4 polymorphisms with neuromyelitis optica spectrum disorders (NMOSD), an inflammatory, demyelinating autoimmune disease of the central nervous system, has not yet been investigated. To evaluate whether TNFSF4 polymorphisms contribute to risk of NMOSD, four single-nucleotide polymorphisms (SNPs) (rs1234315, rs2205960, rs704840, and rs844648) were selected and genotyped in a cohort of 312 patients with NMOSD and 487 healthy controls...
October 14, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29029334/effect-of-long-term-hydroxychloroquine-on-vascular-events-in-patients-with-systemic-lupus-erythematosus-a-database-prospective-cohort-study
#10
Chung-Yuan Hsu, Yu-Sheng Lin, Yu-Jih Su, Hsing-Fen Lin, Ming-Shyan Lin, Ya-Jhu Syu, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Tien-Hsing Chen
Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Methods: We designed a prospective cohort study within an SLE population based on the National Health Insurance Research Database in Taiwan. We divided participants into HCQ and control groups according to HCQ prescription during the first year...
September 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28993952/discordance-of-the-framingham-cardiovascular-risk-score-and-the-2013-american-college-of-cardiology-american-heart-association-risk-score-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#11
Kashif Jafri, Alexis Ogdie, Atif Qasim, Sarah L Patterson, Milena Gianfrancesco, Zara Izadi, Patricia Katz, Jinoos Yazdany, Gabriela Schmajuk
Despite the increasing use of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cardiovascular (CV) risk score in clinical practice, few studies have compared this score to the Framingham risk score among rheumatologic patients. We calculated Framingham and 2013 ACC/AHA risk scores in subjects with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and assessed demographic, CV, and rheumatologic characteristics associated with discordant scores (high-risk ACC/AHA scores but low-risk Framingham scores)...
October 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28992796/subcortical-gray-matter-atrophy-is-associated-with-cognitive-deficit-in-multiple-sclerosis-but-not-in-systemic-lupus-erythematosus-patients
#12
A Kalinowska-Łyszczarz, M A Pawlak, A Pietrzak, K Pawlak-Buś, P Leszczyński, M Puszczewicz, D Majewski, W Paprzycki, W Kozubski, S Michalak
Cognitive impairment is a significant clinical problem both in multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients. In MS cognitive dysfunction has been associated with brain atrophy and total demyelinating lesion volume. In SLE cognitive impairment is much less understood, and its link to structural brain damage remains to be established. The aim of this study was to identify the relationship between subcortical gray matter volume and cognitive impairment in MS and SLE. We recruited 37 MS and 38 SLE patients matched by age, disease duration and educational level...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28992184/immune-complexes-containing-serum-b-cell-activating-factor-and-immunoglobulin-g-correlate-with-disease-activity-in-systemic-lupus-erythematosus
#13
Justa Friebus-Kardash, Leonore Branco, Camillo Ribi, Carlo Chizzolini, Uyen Huynh-Do, Denise Dubler, Pascale Roux-Lombard, Sebastian Dolff, Andreas Kribben, Ute Eisenberger, Marten Trendelenburg
Background: B-cell activating factor belonging to the TNF family (BAFF) is important for the survival of autoreactive B-cells in systemic lupus erythematosus (SLE). However, the association between serum BAFF levels and SLE disease activity is controversial. Independently, autoantibodies targeting BAFF [immunoglobulin G (IgG) anti-BAFF] have also been described in SLE patients and were associated with increased disease activity. The aim of our study was to analyse the relationship between SLE disease manifestations and serum levels of BAFF, IgG anti-BAFF and BAFF-IgG complexes...
August 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28989103/antimalarial-drug-toxicities-in-patients-with-cutaneous-lupus-and-dermatomyositis-a-retrospective-cohort-study
#14
Lavanya Mittal, Lingqiao Zhang, Rui Feng, Victoria P Werth
BACKGROUND: Although existing evidence demonstrates the efficacy of antimalarials for rheumatic skin disease, the safety of these medications, and particularly quinacrine, remain debated. OBJECTIVE: We investigate the toxicity risk associated with antimalarials in patients with cutaneous lupus erythematosus (CLE) and dermatomyositis (DM). METHODS: 532 patients (Mean age=52.29 years, Female=85.15%, Male=14.85%) were selected from two databases of CLE (69...
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28988206/cigarette-smoking-and-the-risk-of-systemic-lupus-erythematosus-overall-and-by-anti-double-stranded-dna-antibody-subtype-in-the-nurses-health-study-cohorts
#15
Medha Barbhaiya, Sara K Tedeschi, Bing Lu, Susan Malspeis, David Kreps, Jeffrey A Sparks, Elizabeth W Karlson, Karen H Costenbader
OBJECTIVES: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, subtyped according to clinical manifestations and autoantibodies. Evidence concerning cigarette smoking and SLE risk has been conflicting. We investigated smoking and SLE risk, overall and by anti-double stranded DNA (dsDNA) presence, in two prospective cohort studies. METHODS: The Nurses' Health Study (NHS) enrolled 121 701 US female nurses in 1976; Nurses' Health Study II (NHSII) enrolled 116 430 in 1989...
October 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28979971/treatment-of-psychiatric-disorders-and-skin-restricted-lupus-remission-a-longitudinal-study
#16
Isabelle Jalenques, Fabien Rondepierre, Catherine Massoubre, Bruno Labeille, Jean-Luc Perrot, Aurélien Mulliez, Michel D'Incan
No abstract text is available yet for this article.
October 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28970217/lupus-low-disease-activity-state-is-associated-with-a-decrease-in-damage-progression-in-caucasian-patients-with-sle-but-overlaps-with-remission
#17
Margherita Zen, Luca Iaccarino, Mariele Gatto, Francesca Saccon, Maddalena Larosa, Anna Ghirardello, Leonardo Punzi, Andrea Doria
OBJECTIVE: To evaluate the prevalence, duration and effect on damage accrual of the 'Lupus Low Disease Activity State' (LLDAS) in a monocentric cohort of patients with systemic lupus erythematosus (SLE). METHODS: We studied 293 Caucasian patients with SLE during a 7-year follow-up period. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2K) and SELENA-SLEDAI physician global assessment (PGA), and damage by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)...
September 26, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28954590/tubular-basement-membrane-immune-complex-deposition-is-associated-with-activity-and-progression-of-lupus-nephritis-a-large-multicenter-chinese-study
#18
H Wang, J Xu, X Zhang, Y L Ren, M Cheng, Z L Guo, J C Zhang, H Cheng, G L Xing, S X Wang, F Yu, M H Zhao
Tubulointerstitial injury is found frequently in lupus nephritis. Immune complex deposits can occur in the tubular basement membranes (TBMs), although its significance in lupus nephritis patients remains unclear. This study assessed the clinical and prognostic features of lupus nephritis patients with TBM deposits in a large Chinese multicenter cohort. Complete data were collected from 195 patients with renal biopsy-proven lupus nephritis diagnosed in the Peking University First Hospital as the discovery cohort...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28952322/coexistence-of-antiphospholipid-antibodies-and-cephalalgia
#19
Md Asiful Islam, Fahmida Alam, Siew Hua Gan, Cinzia Cavestro, Kah Keng Wong
Background The occurrence of antiphospholipid antibodies (aPLs) and headache comorbidity in the presence or absence of underlying autoimmune diseases remains unclear. Aim The aim of this review was to summarize the relationship between headache and aPLs based on evidences from cohort studies and case reports, in addition to examining the treatment strategies that resolved headache in aPLs-positive individuals. Methods A comprehensive literature search was conducted through PubMed, ISI Web of Science and Google Scholar...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28950993/validation-of-the-systemic-lupus-international-collaborating-clinics-classification-criteria-in-a-cohort-of-patients-with-full-house-glomerular-deposits
#20
Emilie C Rijnink, Y K Onno Teng, Tineke Kraaij, Olaf M Dekkers, Jan A Bruijn, Ingeborg M Bajema
In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) presented a new classification for systemic lupus erythematosus (SLE). In this classification, biopsy-confirmed lupus nephritis with positive antinuclear or anti-double-stranded DNA antibodies became a stand-alone criterion. Because of the unknown diagnostic performance among patients from nephrology clinics, we aimed to test the validity of the SLICC classification, compared with the American College of Rheumatology classification, in a cohort of patients whose renal biopsies would raise the clinicopathologic suspicion of lupus nephritis...
September 23, 2017: Kidney International
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