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https://www.readbyqxmd.com/read/27910867/effects-of-annual-influenza-vaccination-on-morbidity-and-mortality-in-patients-with-systemic-lupus-erythematosus-a-nationwide-cohort-study
#1
Chi-Ching Chang, Yu-Sheng Chang, Wei-Sheng Chen, Yi-Hsuan Chen, Jin-Hua Chen
Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan's insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909085/a-negative-antinuclear-antibody-does-not-indicate-autoantibody-negativity-in-myositis-role-of-anticytoplasmic-antibody-as-a-screening-test-for-antisynthetase-syndrome
#2
Rohit Aggarwal, Namrata Dhillon, Noreen Fertig, Diane Koontz, Zengbiao Qi, Chester V Oddis
OBJECTIVE: To evaluate the utility of anticytoplasmic autoantibody (anti-CytAb) in antisynthetase antibody-positive (anti-SynAb+) patients. METHODS: Anti-SynAb+ patients were evaluated for antinuclear antibody (ANA) and anti-CytAb [cytoplasmic staining on indirect immunofluorescence (IIF)] positivity. Anti-SynAb+ patients included those possessing anti-Jo1 and other antisynthetase autoantibodies. Control groups included scleroderma, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, and healthy subjects...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27900999/evaluating-anti-smd1-amino-acid-83-119-peptide-reactivity-in-children-with-systemic-lupus-erythematosus-and-other-immunological-diseases
#3
Hai-Ou Yang, Xiao-Qing Zhang, Qi-Hua Fu
BACKGROUND: SmD1-amino-acid 83-119 peptide (SmD183-119) is the major epitope of Smith (Sm) antigen, which is specific for adult systemic lupus erythematosus (SLE). The anti-SmD183-119 antibody has exhibited higher sensitivity and specificity than anti-Sm antibody in diagnosing adult SLE. However, the utility of anti-SmD183-119antibodies remains unclear in children with SLE (cSLE). This study aimed to assess the characteristics of anti-SmD183-119antibody in the diagnosis of cSLE. METHODS: Samples from 242 children with different rheumatological and immunological disorders, including autoimmune diseases (SLE [n = 46] and ankylosing spondylitis [AS, n = 11]), nonautoimmune diseases (Henoch-Schonlein purpura [HSP, n = 60], idiopathic thrombocytopenia purpura [n = 27], hematuria [n = 59], and arthralgia [n = 39]) were collected from Shanghai Children's Medical Center from March 6, 2012 to February 27, 2014...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27899012/disease-outcomes-and-care-fragmentation-among-patients-with-systemic-lupus-erythematosus
#4
Theresa L Walunas, Kathryn L Jackson, Anh H Chung, Karen A Mancera-Cuevas, Daniel L Erickson, Rosalind Ramsey-Goldman, Abel Kho
OBJECTIVE: To examine the impact of care fragmentation across multiple healthcare institutions on disease outcomes in patients with systemic lupus erythematosus (SLE). METHODS: Using the Chicago HealthLNK Data Repository (HDR), an assembly of electronic health records from six institutions, we identified patients with SLE, using ICD-9 codes, whose care was delivered at more than one organization. We examined whether patients had severe infections or comorbidities (ICD-9 code defined) that indicate SLE-induced damage...
November 29, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27893665/is-it-relevant-to-screen-young-women-hospitalized-in-psychiatric-department-for-neuropsychiatric-systemic-lupus-erythematosus-npsle-a-prospective-study-of-100-psychiatric-inpatients
#5
Alexandra Audemard-Verger, Elizabeth Comby, Clément Nathou, Audrey Sultan, Mathieu Frémont, Aurélie Baldolli, Louis Simon Trumier, Vincent Marzloff, Brigitte Le Mauff, Jennifer Manuzak, Sonia Dollfus, Boris Bienvenu
On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients.We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27887639/prevalence-sensitivity-and-specificity-of-antibodies-against-carbamylated-proteins-in-a-monocentric-cohort-of-patients-with-rheumatoid-arthritis-and-other-autoimmune-rheumatic-diseases
#6
Arbi Pecani, Cristiano Alessandri, Francesca Romana Spinelli, Roberta Priori, Valeria Riccieri, Manuela Di Franco, Fulvia Ceccarelli, Tania Colasanti, Monica Pendolino, Riccardo Mancini, Simona Truglia, Cristiana Barbati, Marta Vomero, Danilo Sabatinelli, Francesca Morello, Guido Valesini, Fabrizio Conti
BACKGROUND: Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to anti-citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF), replicating the existing data in a large cohort of Italian patients with RA and extending the evaluation to other autoimmune rheumatic diseases (AIRDs). METHODS: Serum samples (n = 607) from 309 patients with RA, 200 disease controls and 98 normal healthy subjects (NHS) were evaluated...
November 25, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27884821/the-effect-of-different-durations-of-remission-on-damage-accrual-results-from-a-prospective-monocentric-cohort-of-caucasian-patients
#7
Margherita Zen, Luca Iaccarino, Mariele Gatto, Silvano Bettio, Francesca Saccon, Anna Ghirardello, Leonardo Punzi, Andrea Doria
AIM: To identify the shortest duration of remission associated with improved outcomes in systemic lupus erythematosus (SLE). METHODS: We studied 293 Caucasian patients with SLE during 7-year follow-up. Disease activity was assessed by SLE Disease Activity Index 2000 and damage by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We defined three remission levels: complete, clinical off-corticosteroids, clinical on-corticosteroids (prednisone 1-5 mg/day)...
November 24, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27878954/biomarkers-of-systemic-lupus-erythematosus-identified-using-mass-spectrometry-based-proteomics-a-systematic-review
#8
REVIEW
Orthodoxia Nicolaou, Andreas Kousios, Andreas Hadjisavvas, Bernard Lauwerys, Kleitos Sokratous, Kyriacos Kyriacou
Advances in mass spectrometry technologies have created new opportunities for discovering novel protein biomarkers in systemic lupus erythematosus (SLE). We performed a systematic review of published reports on proteomic biomarkers identified in SLE patients using mass spectrometry-based proteomics and highlight their potential disease association and clinical utility. Two electronic databases, MEDLINE and EMBASE, were systematically searched up to July 2015. The methodological quality of studies included in the review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27878407/low-serum-fibroblast-growth-factor-2-levels-not-accompanied-by-increased-serum-pentraxin-3-levels-in-patients-with-systemic-sclerosis
#9
Ufuk İlgen, Müçteba Enes Yayla, Nurşen Düzgün
There are scarce clinical data regarding serum pentraxin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with systemic sclerosis (SSc). Study was conducted to evaluate serum levels in our SSc cohort. Serum PTX3 and FGF2 concentrations were compared among SSc, disease control (systemic lupus erythematosus (SLE)), and healthy control groups. We also examined the association of serum levels of PTX3 and FGF2 with disease manifestations. Serum PTX3 levels were similarly distributed among SSc (n = 93) and healthy groups (n = 66) (p = 1...
November 22, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27870763/the-effect-of-psychosocial-and-neuropsychiatric-factors-on-medication-adherence-in-a-cohort-of-women-with-systemic-lupus-erythematosus
#10
Cindy Flower, Ian Hambleton, Mike Campbell
BACKGROUND: Medication adherence in systemic lupus erythematosus (SLE) reduces disease activity and the risk of flares. OBJECTIVES: We evaluated adherence in women with SLE who exhibit high morbidity and mortality. We evaluated demographic data and 2 conventional adherence predictors: self-efficacy and health literacy, along with 2 potential neuropsychiatric SLE complications: cognitive dysfunction and depression. METHODS: One hundred six women randomly selected from the Barbados National Lupus Registry completed the Self-efficacy for Appropriate Medication Use Scale, Rapid Estimate of Adult Literacy in Medicine-Short Form, Cognitive Symptom Inventory, Beck Depression Inventory II, and Morisky's Medication Adherence Questionnaire (MAQ)...
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27865435/-the-pulse-mass-index-as-a-predictor-of-cardiovascular-events-in-women-with-systemic-lupus-erythematosus
#11
Elsy Aidé García-Villegas, Horacio Márquez-González, Luis Felipe Flores-Suárez, Antonio Rafael Villa-Romero
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have 3times the risk of death compared to the rest of the population, with cardiovascular events (CVD) being one of the main causes. Índices such as waist-height (W-Ht I), waist-hip (W-Hp I) and pulse-mass (PMI) predict CVD, though the behaviour is unknown in patients with SLE. The aim of this study was to determine the prognostic value of PMI in the development of CVD in premenopausal women with SLE. METHODOLOGY: Cohort study...
November 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27855151/advances-in-the-care-of-children-with-lupus-nephritis
#12
Scott E Wenderfer, Natasha M Ruth, Hermine I Brunner
The care of children with lupus nephritis (LN) has changed dramatically over the past 50 years. The majority of patients with childhood-onset systemic lupus erythematosus (cSLE) develop LN. In the 1960's, prognosis in children was worse than in adults; therapies were limited and toxic. Nearly half of cases resulted in death within 2-years. Since this time, several diagnostic recommendations and disease-specific indices have been developed to assist physicians caring for patients with LN. Pediatric researchers are validating and adapting these indices and guidelines for the treatment of LN in cSLE...
November 17, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27852933/prolactin-levels-are-associated-with-a-pro-inflammatory-body-mass-distribution-among-women-with-systemic-lupus-erythematosus
#13
C Elera-Fitzcarrald, M F Ugarte-Gil, R V Gamboa-Cárdenas, F Zevallos, M Medina, J M Cucho-Venegas, R A Perich-Campos, J L Alfaro-Lozano, Z Rodriguez-Bellido, G S Alarcón, C A Pastor-Asurza
OBJECTIVES: The objective of this study was to determine whether prolactin levels are associated with a pro-inflammatory body mass distribution in women with systemic lupus erythematosus (SLE). METHODS: This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015. Prolactin was measured in ng/ml. Body mass distribution was measured by dual energy x-ray absorptiometry and it was divided into subtotal (whole body excluding the head), subtotal bone mineral content, lean mass index (appendicular lean mass/height(2)), subtotal trunk and leg fat percentages and trunk-to-leg fat ratio...
November 16, 2016: Lupus
https://www.readbyqxmd.com/read/27846298/damage-in-the-multiethnic-malaysian-systemic-lupus-erythematosus-sle-cohort-comparison-with-other-cohorts-worldwide
#14
Syahrul Sazliyana Shaharir, Heselynn Hussein, Sakthiswary Rajalingham, Mohd Shahrir Mohamed Said, Abdul Halim Abdul Gafor, Rozita Mohd, Ruslinda Mustafar
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and despite the improvement in the survival in the past few decades, the morbidity due to disease damage remains significant. The objectives of this study were to investigate the disease damagepattern and determine the associated factors of damage in the multi-ethnic Malaysian SLE patients. We consecutively 424SLE patients who attended a consistent follow-up at the National University of Malaysia Medical Centre and Putrajaya Hospital were recruited...
2016: PloS One
https://www.readbyqxmd.com/read/27837197/comparison-of-ethnicity-gender-age-of-onset-and-outcome-in-south-africans-with-systemic-lupus-erythematosus
#15
A Budhoo, G M Mody, T Dubula, N Patel, P G Mody
Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58.1%) Indians, 137 (33.6%) African Blacks, 17 (4.2%) Mixed ethnicity and 17 (4.2%) Whites. The most common manifestations were arthritis (80.6%), photosensitivity (67.2%), oral ulcers (50.0%), malar rash (49.0%) and renal (39.2%). The common laboratory findings were positive anti-nuclear factor (96.8%), haematological (74...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27831540/time-trend-and-risk-factors-of-avascular-bone-necrosis-in-patients-with-systemic-lupus-erythematosus
#16
Sau Mei Tse, Chi Chiu Mok
OBJECTIVES: The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). METHODS: Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database and compared with those without AVN, matched for age, sex and SLE duration. The standardized incidence ratios (SIRs) of AVN in different SLE age groups were calculated from data derived from our hospital registry and population census...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27831538/proteinuria-selectivity-index-as-a-prognostic-biomarker-in-lupus-nephritis
#17
T Hasegawa, K Suzuki, Y Kaneko, T Takeuchi
OBJECTIVES: The selectivity index has been proposed in predicting the response to immunosuppressive therapy in nephrotic syndrome and other primary kidney disorders. The aim of this study was to elucidate the predictive value of the selectivity index for the treatment response and renal outcome in patients with lupus nephritis. METHODS: Forty-four patients with lupus nephritis with selectivity index available at the time of renal biopsy were divided into two groups according to the cut-off value of the selectivity index determined by a receiver operating characteristics curve to differentiate treatment responders from non-responders...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27831535/autoantibodies-persist-in-relatives-to-systemic-lupus-erythematosus-patients-during-12-years-follow-up
#18
H Langkilde, A Voss, N Heegaard, H Laustrup
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease with presence of autoantibodies and characteristic multi-organ involvement. Relatives of SLE patients have an increased risk of autoantibody production and autoimmune diseases. METHODS: In 2001, 226 first degree relatives (FDRs) of a population-based cohort of SLE patients were examined for the prevalence of autoantibodies and self-reported health complaints. In 2013, 143 FDRs were re-investigated and deceased's medical records were examined...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27829463/frequency-and-predictors-of-the-lupus-low-disease-activity-state-in-a-multi-national-and-multi-ethnic-cohort
#19
Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Alfred Lok Lee, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V Navarra, Leonid Zamora, Yeong-Jian Wu, Laniyati Hamijoyo, Madelynn Chan, Sean O'Neill, Fiona Goldblatt, Eric Francis Morand, Mandana Nikpour
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE...
November 9, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27803306/both-prolonged-remission-and-lupus-low-disease-activity-state-are-associated-with-reduced-damage-accrual-in-systemic-lupus-erythematosus
#20
Michel W P Tsang-A-Sjoe, Irene E M Bultink, Maaike Heslinga, Alexandre E Voskuyl
OBJECTIVES: To identify predictors of organ damage and specifically the relationship between prolonged disease remission or low disease activity and damage accrual in a longitudinal cohort of SLE patients. METHODS: Data were prospectively assessed including the occurrence of minor/major flares. Once a year remission and Lupus Low Disease Activity State (LLDAS) were determined retrospectively. A prediction model for damage accrual during follow-up was constructed with backward logistic regression analyses...
November 1, 2016: Rheumatology
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