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https://www.readbyqxmd.com/read/29238798/association-between-hypercoagulable-conditions-and-calciphylaxis-in-patients-with-renal-disease-a-case-control-study
#1
Allison S Dobry, Lauren N Ko, Jessica St John, J Mark Sloan, Sagar Nigwekar, Daniela Kroshinsky
Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis. Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD...
December 13, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29233832/exome-wide-association-study-identifies-four-novel-loci-for-systemic-lupus-erythematosus-in-han-chinese-population
#2
Leilei Wen, Caihong Zhu, Zhengwei Zhu, Chao Yang, Xiaodong Zheng, Lu Liu, Xianbo Zuo, Yujun Sheng, Huayang Tang, Bo Liang, Yi Zhou, Pan Li, Jun Zhu, Yantao Ding, Gang Chen, Jinping Gao, Lili Tang, Yuyan Cheng, Jingying Sun, Tamilselvi Elango, Anjana Kafle, Ruixing Yu, Ke Xue, Yaohua Zhang, Feng Li, Zhanguo Li, Jianping Guo, Xuan Zhang, Chen Zhou, Yuanjia Tang, Nan Shen, Meng Wang, Xueqing Yu, Shengxiu Liu, Xing Fan, Min Gao, Fengli Xiao, Peiguang Wang, Zaixing Wang, Anping Zhang, Fusheng Zhou, Liangdan Sun, Sen Yang, Jinhua Xu, Xianyong Yin, Yong Cui, Xuejun Zhang
OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of considerable genetic predisposition. Genome-wide association studies have identified tens of common variants for SLE. However, the majority of them reside in non-coding sequences. The contributions of coding variants have not yet been systematically evaluated. METHODS: We performed a large-scale exome-wide study in 5004 SLE cases and 8179 healthy controls in a Han Chinese population using a custom exome array, and then genotyped 32 variants with suggestive evidence in an independent cohort of 13 246 samples...
December 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29233038/juvenile-systemic-lupus-erythematosus-in-turkey-demographic-clinical-and-laboratory-features-with-disease-activity-and-outcome
#3
S Sahin, A Adrovic, K Barut, N Canpolat, Y Ozluk, I Kilicaslan, S Caliskan, L Sever, O Kasapcopur
Objectives This paper aims to assess in a retrospective fashion the clinical and laboratory features, severity and outcome of juvenile systemic lupus erythematosus (jSLE) from a referral center in Turkey. Methods We have included all jSLE patients ( n = 92) diagnosed according to the revised American College of Rheumatology 1997 criteria between January 2004 and January 2017. Results The most prevalent clinical feature in our cohort was mucocutaneous manifestations (97.8%), followed by constitutional (81...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29230954/association-between-vitamin-d-receptor-polymorphisms-and-systemic-lupus-erythematosus-in-an-indian-cohort
#4
Harishankar Mahto, Rina Tripathy, Bidyut K Das, Aditya K Panda
AIM: Systemic lupus erythematosus (SLE) is an autoimmune disorder with various clinical manifestations. Susceptibility to development of SLE has been linked to several factors, such as genetic, environmental and hormonal. Vitamin D appears to have a regulatory role on disease manifestation and activity. Vitamin D exerts its effect through vitamin D receptors (VDR). Several studies have demonstrated an association between VDR polymorphisms and susceptibility to SLE in different populations, although the results are still inconclusive...
December 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29214035/cardiovascular-risk-profiles-in-a-lupus-cohort-what-do-different-calculators-tell-us
#5
Daniel Boulos, Rachel L Koelmeyer, Eric F Morand, Alberta Y Hoi
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and this risk is increased in patients with SLE who may not conform to traditional cardiovascular risk profiles. Aims: To determine the prevalence of high CVD risk among patients with SLE calculated using different risk calculators, and to characterise those identified as high risk. Methods: A cross-sectional analysis to estimate CVD risk using the Framingham Risk Equation (Framingham score) and an SLE-specific CVD risk equation (SLE score) was undertaken using data from a single centre cohort...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29212518/effect-of-low-and-high-hdl-c-levels-on-the-prognosis-of-lupus-nephritis-patients-a-prospective-cohort-study
#6
Peiran Yin, Ying Zhou, Bin Li, Lingyao Hong, Wei Chen, Xueqing Yu
BACKGROUND: Few data has been available on the effect of serum HDL-C levels on the prognosis of lupus nephritis (LN) patients. The present study therefore aimed to explore the effect of serum HDL-C levels on LN patients. METHODS: We included 775 patients with follow-up information registered in an LN database between 1 January 2006 and 31 December 2011. The patients were divided into groups with low, intermediate and high HDL-C, according to NCEP ATPIII criteria...
December 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29210313/pain-predicts-poorer-health-related-quality-of-life-in-childhood-onset-systemic-lupus-erythematosus-a-cohort-study
#7
Ji Li, Jordan T Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I Brunner
Objectives To investigate the predictive value of pain on health-related quality of life (HRQoL) among patients with childhood-onset systemic lupus erythematous (cSLE), as increased adverse psychosocial events are reported in patients with cSLE, but the predictive impact of psychological events on HRQoL remains unclear. Methods This cohort study recruited patients with cSLE from the Cincinnati Children's Hospital Medical Centre rheumatology clinic. Data regarding pain due to lupus in past week, and HRQoL, were collected during a baseline and 6-month follow-up visit...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29204758/antiphospholipid-antibodies-steroid-dose-arterial-hypertension-relapses-and-late-onset-predict-organ-damage-in-a-population-of-colombian-patients-with-systemic-lupus-erythematosus
#8
Luis F Pinto-Peñaranda, C Muñoz-Grajales, A F Echeverri Garcia, C J Velásquez-Franco, M A Mesa-Navas, M Zuluaga Quintero, S Herrera-Uribe, J D Márquez-Hernández
Organ damage predicts mortality, increased accrual of detriment, and poor quality of life in systemic lupus erythematosus patients. The objective of this study is to determine the damage-free survival and its predictive factors in a population of Colombian subjects. The method used in this study is the retrospective follow-up of a cohort; damage was measured with SLICC/ACR index. Predictors of impairment were assessed by logistic regression and survival analysis. One hundred sixty-one individuals were included; 28...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29196292/gut-microbiota-in-human-sle-and-a-mouse-model-of-lupus
#9
Xin M Luo, Michael R Edwards, Qinghui Mu, Yang Yu, Miranda D Vieson, Christopher M Reilly, S Ansar Ahmed, Adegbenga A Bankole
Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role of gut microbiota in systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by persistent inflammation in multiple organs of the body, remains elusive. Here we report the dynamics of gut microbiota in a murine lupus model, NZB/W F1, as well as intestinal dysbiosis in a small group of SLE patients with active disease. The composition of gut microbiota changed markedly before and after the onset of lupus disease in NZB/W F1 mice, with higher diversity and increased representation of several bacterial species as lupus progressed from pre-disease to the diseased stage...
December 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29194681/a-population-based-study-of-perinatal-infection-risk-in-women-with-and-without-systemic-lupus-erythematosus-and-their-infants
#10
Rachel A Bender Ignacio, Amy T Madison, Ata Moshiri, Noel S Weiss, Beth A Mueller
BACKGROUND: Increased risk of adverse birth outcomes is well described in women with systemic lupus erythematosus (SLE), but risk of maternal or infant infection in the peripartum period has not been well studied. We conducted a population-based cohort study of infection risk in women with and without SLE and their infants. METHODS: Linked birth-hospital discharge data identified 1297 deliveries to women with SLE and a 4:1 comparison cohort of deliveries to women without SLE in Washington State, 1987-2013...
December 1, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29193893/sex-differences-in-healthcare-utilization-end-stage-renal-disease-and-mortality-among-medicaid-beneficiaries-with-incident-lupus-nephritis
#11
Candace H Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H Costenbader
OBJECTIVE: While systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect females, prior studies suggest that males may experience poorer outcomes. We investigated sex differences in healthcare utilization, end-stage renal disease (ESRD) and mortality among patients with LN receiving Medicaid, public insurance for low-income individuals. METHODS: Within Medicaid Analytic eXtract (MAX) from 29 states (2000-2010), we used billing claims to identify individuals 5-65 years with incident LN (PPV 80%)...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29193883/economic-evaluation-of-lupus-nephritis-in-the-systemic-lupus-international-collaborating-clinics-inception-cohort-using-a-multistate-model-approach
#12
Megan R W Barber, John G Hanly, Li Su, Murray B Urowitz, Yvan St Pierre, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Michelle Petri, Ian N Bruce, Paul R Fortin, Dafna D Gladman, Jorge Sanchez-Guerrero, Rosalind Ramsey-Goldman, Munther A Khamashta, Cynthia Aranow, Meggan Mackay, Graciela S Alarcón, Susan Manzi, Ola Nived, Andreas Jönsen, Asad A Zoma, Ronald F van Vollenhoven, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S Sam Lim, Kenneth C Kalunian, Murat Inanc, Diane L Kamen, Christine A Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Vernon Farewell, Ann E Clarke
OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). These were compared between patients with and without LN based on multistate modelling. METHODS: Patients from 32 centres in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria...
November 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29184911/kidney-transplant-recipients-with-primary-membranous-glomerulonephritis-have-a-higher-risk-of-acute-rejection-compared-with-other-primary-glomerulonephritides
#13
Tripti Singh, Brad Astor, Weixiong Zhong, Didier Mandelbrot, Arjang Djamali, Sarah Panzer
Background: Despite being the leading cause of graft failure, there is a lack of published data about the rates of rejection in kidney transplant patients with glomerulonephritis as the cause of end-stage renal disease. Methods: We examined all consecutive adult (>18 years) renal transplant recipients with biopsy-proven native renal glomerular disease who underwent kidney transplant between 1994 and 2013. Glomerulonephritis groups included were IgA nephropathy (IgAN) (N = 306), focal segmental glomerulosclerosis (FSGS) (N = 298), membranous nephropathy (MN) (N = 81), and lupus nephritis (LN) (N = 177)...
November 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29184082/identification-of-a-histone-family-gene-signature-for-predicting-the-prognosis-of-cervical-cancer-patients
#14
Xiaofang Li, Run Tian, Hugh Gao, Yongkang Yang, Bryan R G Williams, Michael P Gantier, Nigel A J McMillan, Dakang Xu, Yiqun Hu, Yan'e Gao
Heterogeneity in terms of tumor characteristics, prognosis, and survival among cancer patients is an unsolved issue. Here, we systematically analyzed the aberrant expression patterns of cervical cancer using RNA-Seq data from The Cancer Genome Atlas (TCGA). We incorporated gene profiling, molecular signatures, functional and pathway information with gene set enrichment and protein-protein interaction (PPI) network analysis, to identify sub-networks of genes. Those identified genes relating to DNA replication and DNA repair-mediated signaling pathways associated with systemic lupus erythematosus (SLE)...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183859/risk-of-autism-spectrum-disorder-in-children-born-to-mothers-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis-in-taiwan
#15
Ping-Han Tsai, Kuang-Hui Yu, I-Jun Chou, Shue-Fen Luo, Wen-Yi Tseng, Lu-Hsiang Huang, Chang-Fu Kuo
OBJECTIVES: To determine whether offspring of Taiwanese mothers with systemic lupus erythematosus or rheumatoid arthritis have a higher risk of autism spectrum disorder. METHODS: Using the National Health Insurance database and National Birth Registry, we identified a cohort of all live-births in Taiwan between 2001 and 2012. Children born to mothers with systemic lupus erythematosus or rheumatoid arthritis were identified and matched with up to 8 controls by maternal age, 1-minute Apgar score, 5-minute Apgar score, mode of delivery, sex of the child, gestational age, birth weight and place of residence...
November 25, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29177435/de-novo-mutations-implicate-novel-genes-in-systemic-lupus-erythematosus
#16
Venu Pullabhatla, Amy L Roberts, Myles J Lewis, Daniele Mauro, David L Morris, Christopher A Odhams, Philip Tombleson, Ulrika Liljedahl, Simon Vyse, Michael A Simpson, Sascha Sauer, Emanuele de Rinaldis, Ann-Christine Syvänen, Timothy J Vyse
The omnigenic model of complex disease stipulates that the majority of the heritability will be explained by the effects of common variation on genes in the periphery of core disease pathways. Rare variant associations, expected to explain far less of the heritability, may be enriched in core disease genes and thus will be instrumental in the understanding of complex disease pathogenesis and their potential therapeutic targets. Here, using complementary whole-exome sequencing, high-density imputation, and in vitro cellular assays, we identify candidate core genes in the pathogenesis of Systemic Lupus Erythematosus (SLE)...
November 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29177060/predictors-of-incident-proteinuria-among-patients-with-sle
#17
Alí Duarte-García, Erik Barr, Laurence S Magder, Michelle Petri
Objective: To identify fixed and time-varying predictors of incident proteinuria. Methods: This analysis was based on patients who did not have a history of diabetes and who did not have a prior episode of renal involvement. We defined an incident case of proteinuria as two or more measures of urine protein to creatinine ratio (or 24-hour protein measure) greater than 0.5 in two visits separated by more than 30 days and less than 180 days. We estimated rates of incident proteinuria in subgroups of patients with lupus defined by time-invariant and time-varying predictors...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29173190/migraine-in-systemic-autoimmune-diseases
#18
Cavestro Cinzia, Ferrero Marcella
BACKGROUND AND OBJECTIVE: Migraine and systemic autoimmune diseases are 2-3-fold more common in women and various studies have reported an association between the two pathologies. METHODS: This review takes into account epidemiological studies involving migraine and systemic lupus erythematosus, antiphospholipid syndrome, Sjogren's syndrome, and other diffuse connective tissue diseases. This scientific literature analysis consists of the main articles found in Medline with a search up to April 2017...
November 24, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29166915/serum-connective-tissue-growth-factor-is-a-highly-discriminatory-biomarker-for-the-diagnosis-of-rheumatoid-arthritis
#19
Xinyu Yang, Ke Lin, Shanmin Ni, Jianmin Wang, Qingqing Tian, Huaijun Chen, Matthew A Brown, Kaidi Zheng, Weitao Zhai, Li Sun, Shengwei Jin, Jianguang Wang
BACKGROUND: Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a biomarker of RA. METHOD: Serum and synovial fluid CTGF was detected using a direct high sensitivity sandwich ELISA kit. Serum CTGF levels were tested for discriminatory capacity and optimal assay cutoffs determined in a training cohort of 98 cases of RA with 103 healthy controls...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29165607/an-evidence-based-approach-to-pre-pregnancy-counselling-for-patients-with-systemic-lupus-erythematosus
#20
Y K Onno Teng, Edwin O W Bredewold, Ton J Rabelink, Tom W J Huizinga, H C Jeroen Eikenboom, Maarten Limper, Ruth D E Fritsch-Stork, Kitty W M Bloemenkamp, Marieke Sueters
Patients with SLE are often young females of childbearing age and a pregnancy wish in this patient group is common. However, SLE patients are at high risk for adverse pregnancy outcomes that require adequate guidance. It is widely acknowledged that pre-pregnancy counselling is the pivotal first step in the management of SLE patients with a wish to become pregnant. Next, management of these patients is usually multidisciplinary and often requires specific expertise from the different physicians involved. Very recently a EULAR recommendation was published emphasizing the need for adequate preconception counselling and risk stratification...
November 20, 2017: Rheumatology
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