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Clizia Guccione, Maria Camilla Bergonzi, Khaled M Awada, Vieri Piazzini, Anna Rita Bilia
The aim of this study was the development and characterization of lipid nanocarriers using food grade components for oral delivery of Serenoa repens CO2 extract, namely microemulsions (MEs) and self-microemulsifying drug delivery systems (SMEDDSs) to improve the oral absorption. A commercial blend (CB) containing 320 of S. repens CO2 extract plus the aqueous soluble extracts of nettle root and pineapple stem was formulated in two MEs and two SMEDDSs. The optimized ME loaded with the CB (CBM2) had a very low content of water (only 17...
March 15, 2018: Planta Medica
Huihui Sun, Naijun Wan, Xinli Wang, Liang Chang, Dazhi Cheng
18p deletion syndrome is a rare chromosomal disease caused by deletion of the short arm of chromosome 18. By using cytogenetic and SNP array analysis, we identified a girl with 18p deletion syndrome exhibiting craniofacial anomalies, intellectual disability, and short stature. G-banding analysis of metaphase cells revealed an abnormal karyotype 46,XX,del(18)(p10). Further, SNP array detected a 15.3-Mb deletion at 18p11.21p11.32 (chr18:12842-15375878) including 61 OMIM genes. Genotype-phenotype correlation analysis showed that clinical manifestations of the patient were correlated with LAMA1, TWSG1, and GNAL deletions...
March 16, 2018: Cytogenetic and Genome Research
Akihiro Suzuki, Takashi Morie, Hakaru Tamukoh
This paper proposes a shared synapse architecture for autoencoders (AEs), and implements an AE with the proposed architecture as a digital circuit on a field-programmable gate array (FPGA). In the proposed architecture, the values of the synapse weights are shared between the synapses of an input and a hidden layer, and between the synapses of a hidden and an output layer. This architecture utilizes less of the limited resources of an FPGA than an architecture which does not share the synapse weights, and reduces the amount of synapse modules used by half...
2018: PloS One
Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
We used the Luminex Bead Array Multiplex Immunoassay to measure cytokines, chemokines and growth factors responses to the same antigens used for RD1-based Interferon γ Release Assay (IGRA) test. Seventy-nine individuals, 27 active TB, 32 latent infection subsets, 20 individuals derivative purified protein (PPD) negative (subjects that do not have any indurative cutaneous reaction after 72 hrs of intradermal injection of PPD) and with other pulmonary disease were retrospectively studied. Forty-eight analytes were evaluated by Luminex Assay in plasma obtained from whole blood stimulated cells...
2018: PloS One
Dasa Cizkova, Veronika Cubinkova, Tomas Smolek, Adriana-Natalia Murgoci, Jan Danko, Katarina Vdoviakova, Filip Humenik, Milan Cizek, Jusal Quanico, Isabelle Fournier, Michel Salzet
It was recently shown that the conditioned medium (CM) of mesenchymal stem cells can enhance viability of neural and glial cell populations. In the present study, we have investigated a cell-free approach via CM from rat bone marrow stromal cells (MScCM) applied intrathecally (IT) for spinal cord injury (SCI) recovery in adult rats. Functional in vitro test on dorsal root ganglion (DRG) primary cultures confirmed biological properties of collected MScCM for production of neurosphere-like structures and axon outgrowth...
March 15, 2018: International Journal of Molecular Sciences
Md Nahid Pervez, Faizan Shafiq, Zahid Sarwar, Muhammad Munib Jilani, Yingjie Cai
In this study, the influence and optimization of the factors of a non-formaldehyde resin finishing process on cotton fabric using a Taguchi-based grey relational analysis were experimentally investigated. An L27 orthogonal array was selected for five parameters and three levels by applying Taguchi's design of experiments. The Taguchi technique was coupled with a grey relational analysis to obtain a grey relational grade for evaluating multiple responses, i.e., crease recovery angle (CRA), tearing strength (TE), and whiteness index (WI)...
March 15, 2018: Materials
Mohammed Saji Salahudeen, Prasad S Nishtala
OBJECTIVE: To summarize studies that used the international Resident Assessment home care instrument (interRAI HC) to examine study outcomes for older people. METHODS: A comprehensive systematic search was performed to identify relevant studies, using five databases from 1990 until October 2016. The Cochrane Risk-Bias assessment tool and Newcastle-Ottawa Scale was used to assess the quality of RCTs and non-RCTs, respectively. RESULTS: Based on the full-text analysis, 40 studies met the inclusion criteria out of 506 total records...
March 2, 2018: Clinical Gerontologist
Miguel A Marioni, Marcos Penedo, Mirko Baćani, Johannes Schwenk, Hans Josef Hug
Mallinson's idea that some spin textures in planar magnetic structures could produce an enhancement of the magnetic flux on one side of the plane at the expense of the other gave rise to permanent magnet configurations known as Halbach magnet arrays. Applications range from wiggler magnets in particle accelerators and free electron lasers, to motors, to magnetic levitation trains, but exploiting Halbach arrays in micro- or nanoscale spintronics devices requires solving the problem of fabrication and field metrology below 100 μm size...
March 15, 2018: Nano Letters
Yuwei Hao, Hongliang Liu, Guannan Li, Haijun Cui, Lei Jiang, Shutao Wang
To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface - poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays - by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing efficiencies of cancer cell capture and release. These enhanced efficiencies of cancer cell capture and release probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units...
March 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Tomoko Kubori, Tomoe Kitao, Hiroki Ando, Hiroki Nagai
The intracellular bacterial pathogen Legionella pneumophila establishes the replicative niche as a result of the actions of a large array of effector proteins delivered via the Legionella type IV secretion system (T4SS). Many effector proteins are expected to be involved in biogenesis and regulation of the Legionella-containing vacuole (LCV) that is highly decorated with ubiquitin. Here, we identified a Legionella deubiquitinase (DUB), designated LotA, by carrying out a genome analysis to find proteins resembling the eukaryotic ovarian tumor (OTU) superfamily of cysteine proteases...
March 15, 2018: Cellular Microbiology
Xiao Ming Zhang, Qiang Zhang, Shang Jie Zeng, Zhen Zhen Liu, Jun-Jun Xiao
High-index dielectric nanoantennas have become an emerging branch of optical nanoantennas, essentially due to their low loss. These types of nanoantennas can achieve both forward and backward unidirectional scattering, enabled by electric dipole and magnetic dipole interaction. Here, we show that the scattering directionality can be further enhanced if higher-order moments are properly balanced and reach the generalized Kerker condition at two different wavelengths in an all-dielectric hollow nanodisk. Moreover, putting the nanodisks in an array of transverse configuration can enhance the unidirectionality to be needle-like, with the main lobe angular beam width α<15°...
March 15, 2018: Optics Letters
Jacob W P Potuijt, Martijn Baas, Rivka Sukenik-Halevy, Hannie Douben, Picard Nguyen, Deon J Venter, Renée Gallagher, Sigrid M Swagemakers, Steven E R Hovius, Christianne A van Nieuwenhoven, Robert-Jan H Galjaard, Peter J van der Spek, Nadav Ahituv, Annelies de Klein
PurposeThe zone of polarizing activity regulatory sequence (ZRS) is an enhancer that regulates sonic hedgehog during embryonic limb development. Recently, mutations in a noncoding evolutionary conserved sequence 500 bp upstream of the ZRS, termed the pre-ZRS (pZRS), have been associated with polydactyly in dogs and humans. Here, we report the first case of triphalangeal thumb-polysyndactyly syndrome (TPT-PS) to be associated with mutations in this region and show via mouse enhancer assays how this mutation leads to ectopic expression throughout the developing limb bud...
March 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Y Wang, S Subhankar, P Bienias, M Łącki, T-C Tsui, M A Baranov, A V Gorshkov, P Zoller, J V Porto, S L Rolston
We report on the experimental realization of a conservative optical lattice for cold atoms with a subwavelength spatial structure. The potential is based on the nonlinear optical response of three-level atoms in laser-dressed dark states, which is not constrained by the diffraction limit of the light generating the potential. The lattice consists of a one-dimensional array of ultranarrow barriers with widths less than 10 nm, well below the wavelength of the lattice light, physically realizing a Kronig-Penney potential...
February 23, 2018: Physical Review Letters
M B Agranat, O V Chefonov, A V Ovchinnikov, S I Ashitkov, V E Fortov, P S Kondratenko
We report on the experimental observation of high-power terahertz-radiation-induced damage in a thin aluminum film with a thickness less than a terahertz skin depth. Damage in a thin metal film produced by a single terahertz pulse is observed for the first time. The damage mechanism induced by a single terahertz pulse could be attributed to thermal expansion of the film causing debonding of the film from the substrate, film cracking, and ablation. The damage pattern induced by multiple terahertz pulses at fluences below the damage threshold is quite different from that observed in single-pulse experiments...
February 23, 2018: Physical Review Letters
C Lin, N Avidor, G Corem, O Godsi, G Alexandrowicz, G R Darling, A Hodgson
Highly corrugated, stepped surfaces present regular 1D arrays of binding sites, creating a complex, heterogeneous environment to water. Rather than decorating the hydrophilic step sites to form 1D chains, water on stepped Cu(511) forms an extended 2D network that binds strongly to the steps but bridges across the intervening hydrophobic Cu(100) terraces. The hydrogen-bonded network contains pentamer, hexamer, and octomer water rings that leave a third of the stable Cu step sites unoccupied in order to bind water H down close to the step dipole and complete three hydrogen bonds per molecule...
February 16, 2018: Physical Review Letters
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, I Al Samarai, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, C Argüelles, J Auffenberg, S Axani, H Bagherpour, X Bai, J P Barron, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, D Berley, E Bernardini, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Bourbeau, F Bradascio, J Braun, L Brayeur, M Brenzke, H-P Bretz, S Bron, J Brostean-Kaiser, A Burgman, T Carver, J Casey, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, J J DeLaunay, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, P A Evenson, S Fahey, A R Fazely, J Felde, K Filimonov, C Finley, S Flis, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, T Glauch, T Glüsenkamp, A Goldschmidt, J G Gonzalez, D Grant, Z Griffith, C Haack, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, B Hokanson-Fasig, K Hoshina, F Huang, M Huber, K Hultqvist, M Hünnefeld, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, P Kalaczynski, W Kang, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, A Kheirandish, J Kim, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, L Köpke, C Kopper, S Kopper, J P Koschinsky, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, A Kyriacou, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, Q R Liu, L Lu, J Lünemann, W Luszczak, J Madsen, G Maggi, K B M Mahn, S Mancina, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, T Menne, G Merino, T Meures, S Miarecki, J Micallef, G Momenté, T Montaruli, R W Moore, M Moulai, R Nahnhauer, P Nakarmi, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, P Peiffer, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, M Plum, P B Price, G T Przybylski, C Raab, L Rädel, M Rameez, K Rawlins, I C Rea, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, T Sälzer, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, S Sarkar, K Satalecka, P Schlunder, T Schmidt, A Schneider, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, J Soedingrekso, D Soldin, M Song, G M Spiczak, C Spiering, J Stachurska, M Stamatikos, T Stanev, A Stasik, J Stettner, A Steuer, T Stezelberger, R G Stokstad, A Stößl, N L Strotjohann, G W Sullivan, M Sutherland, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, C F Tung, A Turcati, C F Turley, B Ty, E Unger, M Usner, J Vandenbroucke, W Van Driessche, N van Eijndhoven, S Vanheule, J van Santen, M Vehring, E Vogel, M Vraeghe, C Walck, A Wallace, M Wallraff, F D Wandler, N Wandkowsky, A Waza, C Weaver, M J Weiss, C Wendt, J Werthebach, S Westerhoff, B J Whelan, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, J Wood, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, T Yuan, M Zoll
We present a measurement of the atmospheric neutrino oscillation parameters using three years of data from the IceCube Neutrino Observatory. The DeepCore infill array in the center of IceCube enables the detection and reconstruction of neutrinos produced by the interaction of cosmic rays in Earth's atmosphere at energies as low as ∼5  GeV. That energy threshold permits measurements of muon neutrino disappearance, over a range of baselines up to the diameter of the Earth, probing the same range of L/E_{ν} as long-baseline experiments but with substantially higher-energy neutrinos...
February 16, 2018: Physical Review Letters
M Fujihala, T Sugimoto, T Tohyama, S Mitsuda, R A Mole, D H Yu, S Yano, Y Inagaki, H Morodomi, T Kawae, H Sagayama, R Kumai, Y Murakami, K Tomiyasu, A Matsuo, K Kindo
Fedotovite K_{2}Cu_{3}O(SO_{4})_{3} is a candidate of new quantum spin systems, in which the edge-shared tetrahedral (EST) spin clusters consisting of Cu^{2+} are connected by weak intercluster couplings forming a one-dimensional array. Comprehensive experimental studies by magnetic susceptibility, magnetization, heat capacity, and inelastic neutron scattering measurements reveal the presence of an effective S=1 Haldane state below T≅4  K. Rigorous theoretical studies provide an insight into the magnetic state of K_{2}Cu_{3}O(SO_{4})_{3}: an EST cluster makes a triplet in the ground state and a one-dimensional chain of the EST induces a cluster-based Haldane state...
February 16, 2018: Physical Review Letters
N Fayard, A Goetschy, R Pierrat, R Carminati
We study theoretically the mutual information between reflected and transmitted speckle patterns produced by wave scattering from disordered media. The mutual information between the two speckle images recorded on an array of N detection points (pixels) takes the form of long-range intensity correlation loops that we evaluate explicitly as a function of the disorder strength and the Thouless number g. Our analysis, supported by extensive numerical simulations, reveals a competing effect of cross-sample and surface spatial correlations...
February 16, 2018: Physical Review Letters
David J Schunter, Martin Brandenbourger, Sophia Perriseau, Douglas P Holmes
Confinement of a slender body into a granular array induces stress localization in the geometrically nonlinear structure, and jamming, reordering, and vertical dislodging of the surrounding granular medium. By varying the initial packing density of grains and the length of a confined elastica, we identify the critical length necessary to induce jamming, and demonstrate how folds couple with the granular medium to localize along grain boundaries. Above the jamming threshold, the characteristic length of elastica deformation is shown to diverge in a manner that is coupled with the motion and rearrangement of the grains, suggesting the ordering of the granular array governs the deformation of the slender structure...
February 16, 2018: Physical Review Letters
Pratibha Ramarao, Neha Bhagwani Topnani, Prutha N
Periodic orientation patterns occurring in nematic gels revealed by optical and scanning electron microscopy are found to be formed by spontaneous self assembly of fibrous aggregates of a low-molecular weight organogelator in an aligned thermotropic liquid crystal (LC). The self organization into the periodic structure is also reflected in a calorimetric study which shows the occurrence of three thermoreversible states viz. isotropic liquid, nematic and nematic gel. The segregation and self assembly of the fibrous aggregates leading to the pattern formation is attributed to the highly polar LC and the hydrogen bonding between gelator molecules as shown by x-ray diffraction and vibrational spectroscopy...
March 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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