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https://www.readbyqxmd.com/read/29793200/influence-of-auxochrome-group-in-disperse-dyes-bearing-azo-groups-as-chromophore-center-in-the-biotransformation-and-molecular-docking-prediction-by-reductase-enzyme-implications-and-assessment-for-environmental-toxicity-of-xenobiotics
#1
Jefferson Honorio Franco, Bianca F da Silva, Elisangela Franciscon G Dias, Alexandre A de Castro, Teodorico C Ramalho, Maria Valnice Boldrin Zanoni
Synthetic azo dyes have increasingly become a matter of great concern as a result of the genotoxic and mutagenic potential of the products derived from azo dye biotransformation. This work evaluates the manner in which reducing enzymes produced by Escherichia coli (E. coli) act on three disperse dyes bearing azo groups, namely Disperse Red 73 (DR 73), Disperse Red 78 (DR 78), and Disperse Red 167 (DR 167). UV-Vis spectrophotometry, high-performance liquid chromatography with diode array detector (HPLC-DAD), and liquid chromatography mass spectrometry (LC-MS/MS) were applied towards the identification of the main products...
May 21, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29793169/spontaneous-rise-in-open-rectangular-channels-under-gravity
#2
Vignesh Thammanna Gurumurthy, Ilia V Roisman, Cameron Tropea, Stephen Garoff
Fluid movement in microfluidic devices, porous media, and textured surfaces involves coupled flows over the faces and corners of the media. Spontaneous wetting of simple grooved surfaces provides a model system to probe these flows. This numerical study investigates the spontaneous rise of a liquid in an array of open rectangular channels under gravity, using the Volume-of-Fluid method with adaptive mesh refinement. The rise is characterized by the meniscus height at the channel center, outer face and the interior and exterior corners...
May 17, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29792967/validated-reverse-phase-hplc-diode-array-method-for-the-quantification-of-intact-bevacizumab-infliximab-and-trastuzumab-for-long-term-stability-study
#3
Antonio Martínez-Ortega, Agustín Herrera, Antonio Salmerón-García, José Cabeza, Luis Cuadros-Rodríguez, Natalia Navas
The aim of the present study was to develop suitable and reliable method for quantification three of the most worldwide used therapeutic monoclonal antibodies (mAbs) -bevazizumab (BVZ), infliximab (INF) and trastuzumab (TTZ)- to be used in long-term stability studies. Reverse phase (RP) was selected by its greater sensibility and reproducibility comparing with other chromatographic modes. Then a high performance liquid chromatography with diode array detection (RP)HPLC/DAD method was checked. Since the three mAbs represent the active ingredient in the medicines in which they are formulated, the selected method was validated for each one in accordance with the International Conference on Harmonization (ICH) guidelines for pharmaceuticals for human use...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792822/genetic-identity-in-genebanks-application-of-the-solcap-12k-snp-array-in-fingerprinting-and-diversity-analysis-in-the-global-in-trust-potato-collection
#4
David Ellis, Oswaldo Chavez, Joseph J Coombs, Julian V Soto, Rene Gomez, David S Douches, Ana Panta, Rocio Silvestre, Noelle Lynette Anglin
Breeders rely on genetic integrity of material from genebanks, however, mislabeling and errors in original data can occur. Paired samples of original material and their in vitro counterparts from 250 diverse potato landrace accessions from the International Potato Center (CIP), were fingerprinted using the Infinium 12K V2 Potato Array to confirm genetic identity and evaluate genetic diversity. Diploid, triploid, and tetraploid accessions were included representing seven cultivated potato taxa (Hawkes, 1990)...
May 24, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29792713/gan-nanowire-arrays-for-efficient-optical-read-out-and-optoelectronic-control-of-nv-centers-in-diamond
#5
Martin Hetzl, Jakob Wierzbowski, Theresa Hoffmann, Max Kraut, Verena Zuerbig, Christoph E Nebel, Kai Müller, Jonathan J Finley, Martin Stutzmann
Solid state quantum emitters embedded in a semiconductor crystal environment are potentially scalable platforms for quantum optical networks operated at room temperature. Prominent representatives are nitrogen-vacancy (NV) centers in diamond showing coherent entanglement and interference with each other. However, these emitters suffer from inefficient optical outcoupling from the diamond and from fluctuations of their charge state. Here, we demonstrate the implementation of regular n-type gallium nitride nanowire arrays on diamond as photonic waveguides to tailor the emission direction of surface-near NV centers and to electrically control their charge state in a p-i-n nano-diode...
May 24, 2018: Nano Letters
https://www.readbyqxmd.com/read/29792677/ultra-low-power-smart-electronic-nose-system-based-on-three-dimensional-tin-oxide-nanotube-arrays
#6
Jiaqi Chen, Zhuo Chen, Farid Boussaid, Daquan Zhang, Xiaofang Pan, Huijuan Zhao, Amine Bermak, Chi-Ying Tsui, Xinran Wang, Zhiyong Fan
In this work, we present a high performance smart electronic nose (E-nose) system consisting of multiplexed tin dioxide (SnO2) nanotube sensor array, read-out circuit, wireless data transmission unit, mobile phone receiver and data processing application (App). Using the proposed nanotube sensor device structure in conjunction with multiple electrode materials, high sensitivity gas detection and discrimination have been achieved at room temperature, enabling a 1,000 times reduction of sensor's power consumption as compared to a conventional device using thin film SnO2...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792668/an-out-of-plane-ionic-conductivity-measurement-configuration-for-high-throughput-experiments
#7
Ruiyun Huang, Christopher J Kucharczyk, Yangang Liang, Xiaohang Zhang, Ichiro Takeuchi, Sossina M Haile
An approach for measuring conductivity of thin-film electrolytes in an out-of-plane configuration, amenable to high-throughput experimentation, is presented. A comprehensive analysis of the geometric requirements for success is performed. Using samaria-doped ceria (Ce0.8Sm0.2O1.9, SDC) excellent agreement between bulk samples and thin films with continuous and patterned electrodes, 100-500 m in diameter, is demonstrated. Films were deposited on conductive Nb-doped SrTiO3, and conductivity measured by A.C...
May 24, 2018: ACS Combinatorial Science
https://www.readbyqxmd.com/read/29792572/galnac-sirna-conjugates-leading-the-way-for-delivery-of-rnai-therapeutics
#8
Aaron D Springer, Steven F Dowdy
Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease. However, before siRNAs can become drugs, they must overcome a billion years of evolutionary defenses designed to keep invading RNAs on the outside cells from getting to the inside of cells. Not surprisingly, significant effort has been placed in developing a wide array of delivery technologies. Foremost of these has been the development of N-acetylgalactosamine (GalNAc) siRNA conjugates for delivery to liver...
May 24, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29792182/boostme-accurately-predicts-dna-methylation-values-in-whole-genome-bisulfite-sequencing-of-multiple-human-tissues
#9
Luli S Zou, Michael R Erdos, D Leland Taylor, Peter S Chines, Arushi Varshney, Stephen C J Parker, Francis S Collins, John P Didion
BACKGROUND: Bisulfite sequencing is widely employed to study the role of DNA methylation in disease; however, the data suffer from biases due to coverage depth variability. Imputation of methylation values at low-coverage sites may mitigate these biases while also identifying important genomic features associated with predictive power. RESULTS: Here we describe BoostMe, a method for imputing low-quality DNA methylation estimates within whole-genome bisulfite sequencing (WGBS) data...
May 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29791962/nerve-entrapment-syndromes-at-the-wrist-and-elbow-by-sonography
#10
Andrea S Klauser, Tommaso Buzzegoli, Mihra S Taljanovic, Sylvia Strobl, Stefan Rauch, James Teh, Julia Wanschitz, Wolfgang Löscher, Carlo Martinoli
Nerve entrapment syndromes of the upper extremity are associated with structural abnormalities or by an intrinsic abnormality of the nerve. Nerve entrapment syndromes generally have a typical clinical presentation, and findings on physical examination and in conjunction with electrodiagnostic studies imaging is used to evaluate the cause, severity, and etiology of the entrapment. With the development of high-frequency linear array transducers (12-24 MHz), ultrasound (US) is incomparable in terms of spatial resolution to depict morphological aspects and changes in nerves...
July 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29791912/differential-expression-of-micrornas-in-breast-cancers-from-four-different-ethnicities
#11
Jennifer Pollard, Phil A Burns, Tom A Hughes, Colan Ho-Yen, J Louise Jones, Geetashree Mukherjee, Ganiat O Omoniyi-Esan, Nicholas Akinwale Titloye, Valerie Speirs, Abeer M Shaaban
INTRODUCTION: Breast cancer outcomes vary across different ethnic groups. MicroRNAs (miRs) are small non-coding RNA molecules that regulate gene expression across a range of pathologies, including breast cancer. The aim of this study was to evaluate the presence and expression of miRs in breast cancer samples from different ethnic groups. MATERIALS AND METHODS: Breast cancer tissue from 4 ethnic groups, i.e., British Caucasian, British Black, Nigerian, and Indian, were identified and matched for patients' age, tumour grade/type, and 10 × 10 µm sections taken...
May 23, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29791867/longitudinal-assessment-of-chemotherapy-induced-changes-in-brain-and-cognitive-functioning-a-systematic-review
#12
REVIEW
Mingmei Li, Karen Caeyenberghs
In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. This review followed the latest PRISMA guidelines using Embase, Medline, PsychINFO, Scopus, and Web of Science databases with date restrictions from 2012-2017...
May 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29791803/bacteria-activated-janus-particles-driven-by-chemotaxis
#13
Zihan Huang, Pengyu Chen, Guo-Long Zhu, Ye Yang, Ziyang Xu, Li-Tang Yan
In the development of biocompatible nano/micro-motors for drug and cargo delivery, motile bacteria represent an excellent energy source for biomedical applications. Despite intense research of the fabrication of bacteria-based motors, how to effectively utilize the instinctive responses of bacteria to environmental stimuli in the fabrication process, particularly, chemotaxis, remains an urgent and critical issue. Here, by developing a molecular-dynamics model of bacterial chemotaxis, we present an investigation of the transport of a bacteria-activated Janus particle driven by chemotaxis...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791750/tiled-array-based-sequencing-identifies-enrichment-of-loss-of-function-variants-in-the-highly-homologous-filaggrin-gene-in-african-american-children-with-severe-atopic-dermatitis
#14
Mary Elizabeth Mathyer, Ashley M Quiggle, X F Colin C Wong, Simon L I J Denil, Monique G Kumar, Heather M Ciliberto, Susan J Bayliss, John E Common, Cristina de Guzman Strong
Filaggrin (FLG) loss of function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD), and are often population-specific. African American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF using exome sequencing is challenging given the known difficulties for accurate short-read alignment to FLG's high homology repeat variation...
May 23, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29791406/controllable-long-focal-length-microlens-based-on-thermal-expansion
#15
Yue Hu, Ying Xiong, Xiangyu Chen, Haobo Bai, Yangchao Tian, Gang Liu
A novel method to fabricate a microlens array with a long focal length has been developed in this paper. It is based on the fabricating and heating of a microlens consisting of two materials with a great difference in coefficient of thermal expansion. A thermal expansion process leads to considerable deformation of the microlens surface and significant increase in focal length, which could be controlled by altering the processing temperature. Cylindrical polymeric microlens arrays with different focal lengths were successfully fabricated...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791396/effective-freeform-tir-lens-designed-for-leds-with-high-angular-color-uniformity
#16
Zhili Zhao, Honghai Zhang, Sheng Liu, Xinzhong Wang
Most LED luminaires face the problem of color nonuniformity in illumination fields, which seriously degrades their lighting quality. To address this issue, we proposed a freeform TIR lens, which could be applied to the most widely adopted phosphor-converted LEDs and multicolor LED arrays. Based on light pattern overlap and energy mapping, the novel TIR lens comprised the freeform panel and the collimator. Analysis of angular color uniformity (ACU), based on a phosphor-converted white LED model, proved that the normalized standard deviation (NSD) of the LED integrated with the freeform TIR lens significantly decreased from 0...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791386/single-frequency-3d-synthetic-aperture-imaging-with-dynamic-metasurface-antennas
#17
Michael Boyarsky, Timothy Sleasman, Laura Pulido-Mancera, Aaron V Diebold, Mohammadreza F Imani, David R Smith
Through aperture synthesis, an electrically small antenna can be used to form a high-resolution imaging system capable of reconstructing three-dimensional (3D) scenes. However, the large spectral bandwidth typically required in synthetic aperture radar systems to resolve objects in range often requires costly and complex RF components. We present here an alternative approach based on a hybrid imaging system that combines a dynamically reconfigurable aperture with synthetic aperture techniques, demonstrating the capability to resolve objects in three dimensions (3D), with measurements taken at a single frequency...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791370/band-optimization-of-passive-methane-gas-leak-detection-based-on-uncooled-infrared-focal-plane-array
#18
Zhang Xu, Weiqi Jin, Li Li, Xia Wang, Ji Chen, YuChao Jia
Current methane gas leak detection technology uses infrared imaging in the medium wave (MW) or long wave (LW) bands, essentially applying cooled infrared detectors. In this study, a simplified three-layer radiative transfer model is adopted based on methane gas detection theory, considering background radiation, atmospheric infrared absorption, gas absorption, and emission characteristics to analyze the contrast of methane gas thermography in different infrared bands. The analysis results suggest that under certain conditions, the 6...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791324/unimorph-mirror-for-adaptive-optics-in-space-telescopes
#19
David Alaluf, Renaud Bastaits, Kainan Wang, Mihaita Horodinca, Grégory Martic, Bilal Mokrani, André Preumont
This paper presents a unimorph deformable mirror intended to be used as secondary corrector in space telescopes. The deformable mirror consists of a single-crystal silicon wafer (76.2 mm diameter, 500 μm thickness) covered with an optical coating on the front side and an array of 25 independent piezoelectric transducer (PZT) actuators acting in d31 mode on the back side. The mirror is mounted on an isostatic support with three position linear actuators controlling the rigid-body motion. The first part of the paper presents the experimental results obtained with the manufactured prototype...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791312/african-crocus-curculigo-pilosa-and-wonderful-kola-buchholzia-coriacea-seeds-modulate-critical-enzymes-relevant-to-erectile-dysfunction-and-oxidative-stress
#20
Stephen A Adefegha, Sunday I Oyeleye, Ganiyu Oboh
Background The seeds of African crocus (AC) (Curculigo pilosa) and wonderful kola (WK) (Buchholzia coriacea) are commonly used in folklore medicine in managing erectile dysfunction (ED) without the full understanding of the possible mechanism of actions. This study investigated and compared the effects of aqueous extracts from the seeds of AC and WK on arginase and acetylcholinesterase (AChE) activities and some pro-oxidant [FeSO4 and sodium nitroprusside (SNP)]-induced lipid peroxidation in rat penile homogenate in vitro...
May 23, 2018: Journal of Complementary & Integrative Medicine
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