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https://www.readbyqxmd.com/read/28927261/hdac11-inhibits-myoblast-differentiation-through-repression-of-myod-dependent-transcription
#1
Sang Kyung Byun, Tae Hyeon An, Min Jeong Son, Da Som Lee, Hyun Sup Kang, Eun-Woo Lee, Baek Soo Han, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh, Sang Chul Lee
Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that regulate muscle differentiation will be useful in the treatment and prevention of these conditions. Protein lysine acetylation and methylation are major post-translational modification mechanisms that regulate key cellular processes. In this study, to elucidate the relationship between myogenic differentiation and protein lysine acetylation/methylation, we performed a PCR array of enzymes related to protein lysine acetylation/ methylation during C2C12 myoblast differentiation...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28927127/vascular-endothelial-growth-factor-and-protein-level-in-pleural-effusion-for-differentiating-malignant-from-benign-pleural-effusion
#2
Da-Wei Wu, Wei-An Chang, Kuan-Ting Liu, Meng-Chi Yen, Po-Lin Kuo
Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#3
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926978/fabrication-of-magnetic-nanofibers-by-needleless-electrospinning-from-a-self-assembling-polymer-ferrofluid-cone-array
#4
Weilong Huang, Bin Liu, Zhipeng Chen, Hongjian Wang, Lei Ren, Jiaming Jiao, Lin Zhuang, Jie Luo, Lelun Jiang
Magnetic nanofiber has been widely applied in biomedical fields due to its distinctive size, morphology, and properties. We proposed a novel needleless electrospinning method to prepare magnetic nanofibers from the self-assembling "Taylor cones" of poly(vinyl pyrrolidone) (PVP)/Fe₃O₄ ferrofluid (PFF) under the coincident magnetic and electric fields. The results demonstrated that a static PFF Rosensweig instability with a conical protrusion could be obtained under the magnetic field. The tip of the protrusion emitted an electrospinning jet under the coincident magnetic and electric fields...
September 17, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28926972/juvenile-moyamoya-and-craniosynostosis-in-a-child-with-deletion-1p32p31-expanding-the-clinical-spectrum-of-1p32p31-deletion-syndrome-and-a-review-of-the-literature
#5
Paolo Prontera, Daniela Rogaia, Amedea Mencarelli, Valentina Ottaviani, Ester Sallicandro, Giorgio Guercini, Susanna Esposito, Anna Bersano, Giuseppe Merla, Gabriela Stangoni
Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterised by the progressive occlusion of the internal carotid artery. Its aetiology is uncertain, but a genetic background seems likely, given the high MA familial rate. To investigate the aetiology of craniosynostosis and juvenile moyamoya in a 14-year-old male patient, we performed an array-comparative genomic hybridisation revealing a de novo interstitial deletion of 8.5 Mb in chromosome region 1p32p31. The deletion involved 34 protein coding genes, including NF1A, whose haploinsufficiency is indicated as being mainly responsible for the 1p32-p31 chromosome deletion syndrome phenotype (OMIM 613735)...
September 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926938/integrin-activation-contributes-to-lower-cisplatin-sensitivity-in-mv3-melanoma-cells-by-inducing-the-wnt-signalling-pathway
#6
Maria B R Piva, Bastian Jakubzig, Gerd Bendas
BACKGROUND: integrins have been associated with the development of chemotherapy resistant tumour cells, mostly those of hematopoietic origin, by mediating the binding to the extracellular matrix. The relevance for solid tumour cells and the underlying mechanisms remain elusive. METHODS: using MTT assays, we detected the loss in cisplatin sensitivity of human MV3 melanoma cells upon integrin activation. Underlying cellular pathways were evaluated by flow cytometry...
September 16, 2017: Cancers
https://www.readbyqxmd.com/read/28926863/evaluation-of-cannabinoid-and-terpenoid-content-cannabis-flower-compared-to-supercritical-co2-concentrate
#7
Michelle Sexton, Kyle Shelton, Pam Haley, Mike West
A recent cannabis use survey revealed that 60% of cannabis users rely on smelling the flower to select their cannabis. Olfactory indicators in plants include volatile compounds, principally represented by the terpenoid fraction. Currently, medicinal- and adult-use cannabis is marketed in the United States with relatively little differentiation between products other than by a common name, association with a species type, and Δ-9 tetrahydrocannabinol/cannabidiol potency. Because of this practice, how terpenoid compositions may change during an extraction process is widely overlooked...
September 19, 2017: Planta Medica
https://www.readbyqxmd.com/read/28926760/laminin-%C3%AE-5-substrates-promote-survival-network-formation-and-functional-development-of-human-pluripotent-stem-cell-derived-neurons-in-vitro
#8
Anu Hyysalo, Mervi Ristola, Meeri E-L Mäkinen, Sergei Häyrynen, Matti Nykter, Susanna Narkilahti
Laminins are one of the major protein groups in the extracellular matrix (ECM) and specific laminin isoforms are crucial for neuronal functions in the central nervous system in vivo. In the present study, we compared recombinant human laminin isoforms (LN211, LN332, LN411, LN511, and LN521) and laminin isoform fragment (LN511-E8) in in vitro cultures of human pluripotent stem cell (hPSC)-derived neurons. We showed that laminin substrates containing the α5-chain are important for neuronal attachment, viability and network formation, as detected by phase contrast imaging, viability staining, and immunocytochemistry...
September 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28926708/molecular-nuances-governing-the-self-assembly-of-1-3-2-4-dibenzylidene-d-sorbitol
#9
Andrew Singh, France-Isabelle Auzanneau, Maria G Corradini, Girishma Grover, Richard G Weiss, Michael A Rogers
1,3:2,4 Dibenzylidene-D-sorbitol (DBS) is the gold-standard for low-molecular-weight organogelators (LMOGs). DBS gelates a wide array of solvents, as illustrated by the large Hansen sphere representing gels (2d = 33.5, p = 7.5, and h = 8.7 MPa1/2; radius = 11.2 MPa1/2). Derivatives of DBS have been synthesised to isolate and determine molecular features essential for organogelation. Herein, π-π stacking and hydrogen-bonding are the major non-covalent interactions examined. The importance of π-π stacking was studied using 1,3:2,4 dicyclohexanecarboxylidene-D-sorbitol (DCHS), which eliminates possible π-π stacking, while still conserving the other structural aspects of DBS...
September 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28926688/covalent-triazine-frameworks-via-a-low-temperature-polycondensation-approach
#10
Kewei Wang, Liming Yang, Xi Wang, Liping Guo, Guang Cheng, Chun Zhang, Shangbin Jin, Bien Tan, Andrew Cooper
Covalent triazine frameworks (CTFs) are normally synthesized by ionothermal methods. The harsh synthetic conditions and associated limited structural diversity do not benefit for further development and practical large-scale synthesis of CTFs. Herein we report a new strategy to construct CTFs (CTF-HUSTs) via a polycondensation approach, which allows the synthesis of CTFs under mild conditions from a wide array of building blocks. Interestingly, these CTFs display a layered structure. The CTFs synthesized were also readily scaled up to gram quantities...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28926408/serum-glycan-binding-igg-antibodies-in-hiv-1-infection-and-during-the-development-of-broadly-neutralizing-responses
#11
Cathrine Scheepers, Sudipa Chowdhury, W Shea Wright, Christopher T Campbell, Nigel J Garrett, Quarraisha Abdool Karim, Salim S Abdool Karim, Penny L Moore, Jeffrey C Gildersleeve, Lynn Morris
BACKGROUND: The HIV-1 envelope is covered with glycans that provide structural integrity and protect conserved regions from host antibody responses. However, these glycans are often the target of broadly neutralizing antibodies (bNAbs) that emerge in some HIV infected individuals. We aimed to determine whether anti-glycan IgG antibodies are a general response to HIV-1 infection or specific to individuals who develop bNAbs. METHODS: IgG binding to glycans was assessed using arrays that contained 245 unique components including N-linked carbohydrates, glycolipids and Tn-peptides...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28926278/planar-optical-nano-antennas-resolve-cholesterol-dependent-nanoscale-heterogeneities-in-the-plasma-membrane-of-living-cells
#12
Raju Regmi, Pamina Martina Winkler, Valentin Flauraud, Kyra Borgman, Carlo Manzo, Juergen Brugger, Herve Rigneault, Jerome Wenger, Maria F Garcia-Parajo
Optical nano-antennas can efficiently confine light into nanoscopic hotspots enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual biomolecules in living cell membranes and their partitioning into cholesterol-dependent lipid nanodomains. Here, we present optical nano-antenna arrays with accessible surface hotspots to study the characteristic diffusion dynamics of phosphoethanolamine (PE) and sphingomyelin (SM) in the plasma membrane of living cells at the nanoscale...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28926229/in-situ-derived-nixfe1-xooh-nife-nixfe1-xooh-nanotube-arrays-from-nife-alloys-as-efficient-electrocatalysts-for-oxygen-evolution
#13
An-Liang Wang, Yu-Tao Dong, Mei Li, Chaolun Liang, Gao-Ren Li
Herein, NixFe1-xOOH/NiFe/NixFe1-xOOH sandwich-structured nanotube arrays (SNTAs) supported on carbon fiber cloth (CFC) (NixFe1-xOOH/NiFe/NixFe1-xOOH SNTAs-CFC) have been developed as flexible high-performance OER catalysts by a facile in-situ electrochemical oxidation of NiFe metallic alloy nanotube arrays (ANTAs) during oxygen evolution process. Benefiting from the advantages of high conductivity, hollow nanotube array and porous strucuture, NixFe1-xOOH/NiFe/NixFe1-xOOH SNTAs-CFC exhibited a low overpotential of ~220 mV at the current density of 10 mA cm-2 and a small Tafel slope of 52 mV dec-1 in alkaline solution, which both are smaller than those of most OER electrocatalysts...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926203/qualitative-and-quantitative-analysis-of-chemical-constituents-in-ardisiae-japonicae-herba
#14
Ke-Yun Yu, Wen Gao, Shang-Zhen Li, Wei Wu, Pei Li, Li-Li Dou, Yuan-Zhong Wang, E-Hu Liu
Ardisiae Japonicae Herba is a well-known traditional Chinese medicine for the treatment of bronchitis conjunctivitis, pneumonia and trauma. In this work, a high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was firstly established for the separation and structural identification of the chemical constituents in Ardisiae Japonicae Herba. A total of 15 compounds including coumarins, flavonoid glycosides, and catechins were identified or tentatively characterized based on their chromatographic behaviors and mass spectral fragmentation and by comparisons with the reference standards...
September 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28926134/early-genetic-aberrations-in-patients-with-sporadic-colorectal-cancer
#15
Brooke R Druliner, Xiaoyang Ruan, Hugues Sicotte, Daniel O'Brien, Hongfang Liu, Jean-Pierre A Kocher, Lisa Boardman
Chromosome instability (CIN) is widely observed in both sporadic and hereditary colorectal cancer (CRC). Defects in APC and WNT signaling are primarily associated with CIN in hereditary CRC, but the genetic causes for CIN in sporadic CRC remain elusive. Using high-density SNP array and exome data from The Cancer Genome Atlas, we characterized loss of heterozygosity (LOH) and copy number variation (CNV) in the peripheral blood, normal colon and corresponding tumor tissue in 15 CRC patients with proficient mismatch repair (MMR) and 24 CRC patients with deficient MMR...
September 19, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28926078/an-expedient-synthesis-of-flexible-nucleosides-via-a-regiocontrolled-enzymatic-glycosylation-of-functionalized-imidazoles
#16
S Vichier-Guerre, L Dugué, F Bonhomme, S Pochet
A versatile two-step synthesis of C4- and C5-arylated 2'-deoxyribosylimidazoles was elaborated using enzymatic N-transglycosylation followed by microwave-assisted Pd-catalysed arylation reactions. We report herein the reaction conditions that permit managing regioselectivity (N3 versus N1-isomers) in the enzymatic glycosylation of 4-iodoimidazole using the nucleoside N-deoxyribosyltransferase from L. leichmannii. Regiocontrolled glycosylation was also observed among several other imidazole derivatives studied, providing simple access to isomers not readily accessible by chemical routes...
September 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28925965/studying-the-structural-significance-of-galectin-design-by-playing-a-modular-puzzle-homodimer-generation-from-human-tandem-repeat-type-heterodimeric-galectin-8-by-domain-shuffling
#17
Anna-Kristin Ludwig, Malwina Michalak, Nadya Shilova, Sabine André, Herbert Kaltner, Nicolai V Bovin, Jürgen Kopitz, Hans-Joachim Gabius
Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching partners. Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to understand the inherent specificity of the functional pairing. We here illustrate its practical implementation in the case of human tandem-repeat-type galectin-8 (Gal-8)...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925948/a-direct-coarray-interpolation-approach-for-direction-finding
#18
Tao Chen, Muran Guo, Limin Guo
Sparse arrays have gained considerable attention in recent years because they can resolve more sources than the number of sensors. The coprime array can resolve O ( M N ) sources with only O ( M + N ) sensors, and is a popular sparse array structure due to its closed-form expressions for array configuration and the reduction of the mutual coupling effect. However, because of the existence of holes in its coarray, the performance of subspace-based direction of arrival (DOA) estimation algorithms such as MUSIC and ESPRIT is limited...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925939/process-and-pitfalls-of-sperm-cryopreservation
#19
REVIEW
Hamoun Rozati, Thomas Handley, Channa Jayasena
Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in men undergoing cancer therapy and allow conception for infertile couples. This article provides a concise and up-to-date review of the literature and covers the latest advances in sperm cryopreservation and its array of clinical indications. Over recent years, the scope of clinical indications used for sperm cryopreservation has expanded widely. Consequently, more patient groups are eligible for sperm freezing, requiring specialist resources and higher running costs...
September 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28925690/fiber-alignment-and-liquid-crystal-orientation-of-cellulose-nanocrystals-in-the-electrospun-nanofibrous-mats
#20
Weiguang Song, Dagang Liu, Nana Prempeh, Renjie Song
Sulfate cellulose nanocrystal (CNC) dispersions always present specific self-assembled cholesteric mesophases which is easily affected by the inherent properties of particle size, surface charge and repulsion or affinity interaction, and external field force generated from ionic potential of added electrolytes, magnetic, electric, and/or mechanical shearing or stretching. Aiming at understanding the liquid crystal orientation and fiber alignment under high-voltage electric field, randomly distributed, uniform-aligned, or core-sheath nanofibrous mats involving PVA and charged CNCs were electrospun; and amongst them, specific straight arrayed fine nanofibers wi...
September 19, 2017: Biomacromolecules
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