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https://www.readbyqxmd.com/read/28743131/the-spatial-extent-of-epiretinal-electrical-stimulation-in-the-healthy-mouse-retina
#1
Zohreh Hosseinazdeh, Archana Jalligampala, Eberhart Zrenner, Daniel Lleweylln Rathbun
BACKGROUND/AIMS: Retinal prostheses use electrical stimulation to restore functional vision to patients blinded by retinitis pigmentosa. A key detail is the spatial pattern of ganglion cells activated by stimulation. Therefore, we characterized the spatial extent of network-mediated electrical activation of retinal ganglion cells (RGCs) in the epiretinal monopolar electrode configuration. METHODS: Healthy mouse RGC activities were recorded with a micro-electrode array (MEA)...
July 26, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/28743033/analysis-of-the-genetic-structure-of-the-malay-population-ancestry-informative-marker-snps-in-the-malay-of-peninsular-malaysia
#2
Padillah Yahya, Sarina Sulong, Azian Harun, Hatin Wan Isa, Nur-Shafawati Ab Rajab, Pongsakorn Wangkumhang, Alisa Wilantho, Chumpol Ngamphiw, Sissades Tongsima, Zilfalil Alwi
Malay, the main ethnic group in Peninsular Malaysia, is represented by various sub-ethnic groups such as Melayu Banjar, Melayu Bugis, Melayu Champa, Melayu Java, Melayu Kedah Melayu Kelantan, Melayu Minang and Melayu Patani. Using data retrieved from the MyHVP (Malaysian Human Variome Project) database, a total of 135 individuals from these sub-ethnic groups were profiled using the Affymetrix GeneChip Mapping Xba 50-K single nucleotide polymorphism (SNP) array to identify SNPs that were ancestry-informative markers (AIMs) for Malays of Peninsular Malaysia...
July 14, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28742980/disease-relevant-modifications-of-the-methylome-and-transcriptome-by-particulate-matter-pm2-5-from-biomass-combustion
#3
Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort, Matjaz Humar
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated with CpG islands...
July 25, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28742649/thoracoscopic-implantation-of-an-array-electrode-in-the-pericardium-transverse-sinus-to-reduce-defibrillation-threshold
#4
Antonio Curnis, Claudio Muneretto, Gianluigi Bisleri, Manuel Cerini, Lorenza Inama, Francesca Salghetti, Raffaella De Vito, Laura Giroletti, Fabrizio Rosati, Daniele Giacopelli, Francesca Vassanelli, Luca Bontempi
Among the implantable cardioverter defibrillator recipients, there is still a subgroup of patients in whom the defibrillation threshold is too high and the maximal shock output of the implantable cardioverter defibrillator can fail to terminate a ventricular arrhythmia. We report a new thoracoscopic minimally invasive approach to place a standard array electrode in the transverse pericardial sinus of a patient implanted with a cardiac resynchronization and defibrillation therapy device with persistent high defibrillation threshold...
July 25, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28742317/disposable-microfluidic-immunoarray-device-for-sensitive-breast-cancer-biomarker-detection
#5
Ricardo A G de Oliveira, Elsa María Materón, Matias Eliseo Melendez, Andre L Carvalho, Ronaldo C Faria
Breast cancer is the most common cancer in women worldwide. The detection of biomarkers has played a significant role in the early diagnosis and prognosis of breast cancer. Herein, we describe the construction of a disposable microfluidic immunoarray device (DµID) for rapid and low-cost detection of CA15-3 a protein biomarker for breast cancer. The DµID was constructed using a simple and rapid prototyping technique and was applied to detect CA15-3 in cancer patients. The DµID construction was based on a use of double-sided adhesive card with the microfluidic channel and a screen-printed array with 8 electrodes...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28742308/nonaccidental-injury-in-pediatric-patients-detection-evaluation-and-treatment-digest
#6
Gunjan Tiyyagura, Meghan Beucher, Kirsten Bechtel, Kathryn H Pade
Emergency clinicians are likely to encounter physical abuse in children, and they must be prepared to recognize its many manifestations and take swift action. Pediatric nonaccidental injury causes considerable morbidity and mortality that can often be prevented by early recognition. Nonaccidental injuries present with a wide array of symptoms that may appear to be medically inconsequential (such as bruising in a premobile infant), but are actually sentinel injuries indicative of child abuse. This issue provides guidance regarding factors that contribute to abuse in children, key findings on history and physical examination that should trigger an evaluation for physical abuse, and laboratory and radiologic tests to perform when child abuse is suspected...
July 21, 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28742278/agenesis-of-the-corpus-callosum-developmental-delay-autism-spectrum-disorder-facial-dysmorphism-and-posterior-polymorphous-corneal-dystrophy-associated-with-zeb1-gene-deletion
#7
Ayeshah Chaudhry, Brian H Chung, Dimitri J Stavropoulos, Marcela P Araya, Asim Ali, Elise Heon, David Chitayat
We report on a girl diagnosed prenatally with agenesis of the corpus callosum (ACC) on fetal ultrasound and MRI. On postnatal follow-up she was noted to have developmental delay, facial dysmorphism, autism spectrum disorder, and posterior polymorphous corneal dystrophy (PPD). Array-comparative genomic hybridization analysis (Array-CGH) showed a 2.05 Mb de novo interstitial deletion at 10p11.23p11.22. The deleted region overlaps 1 OMIM Morbid Map gene, ZEB1 (the zinc finger E-box binding homeobox transcription factor 1), previously associated with posterior polymorphous corneal dystrophy type 3 (PPCD3)...
July 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28742222/disruption-of-the-atp-adenosine-balance-in-cd39-mice-is-associated-with-handling-induced-seizures
#8
Amanda J Lanser, Rafael M Rezende, Stephen Rubino, Paul J Lorello, Dustin J Donnelly, Huixin Xu, Lauren A Lau, Chris G Dulla, Barbara J Caldarone, Simon C Robson, Howard L Weiner
Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurologic disease. Herein, we report handling-induced and spontaneous seizures in mice deficient of CD39, a cell-surface ATPase highly expressed on microglial cells. CD39(-/-) mice with handling-induced seizures had normal input-output curves and paired-pulse ratio measured from hippocampal slices and lacked microgliosis, astrogliosis or overt cell loss in the hippocampus and cortex...
July 25, 2017: Immunology
https://www.readbyqxmd.com/read/28742044/multipolar-field-shaping-in-a-suprachoroidal-visual-prosthesis
#9
Calvin D Eiber, Socrates Dokos, Nigel H Lovell, Gregg J Suaning
Visual prostheses are now an available mobility aid for patients blinded by degenerative retinal diseases. However, the spatial resolution of existing devices is still insufficient to deliver normal levels of mobility vision without stimulation strategies which enable existing devices to deliver several different percepts per stimulation site. A stimulation strategy in which field shaping is achieved by incorporating multipolar (bipolar and tripolar) stimulation could convey additional information to a user of a visual prosthesis, as compared to monopolar stimulation, is investigated...
July 24, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28742043/mixed-modality-stimulation-to-evoke-two-modalities-simultaneously-in-one-channel-for-electrocutaneous-sensory-feedback
#10
Kyunghwan Choi, Pyungkang Kim, Kyung-Soo Kim, Soohyun Kim
One of the long-standing challenges in upper limb prosthetics is restoring the sensory feedback that is missing due to amputation. Two approaches have previously been presented to provide various types of sensory information to users, namely, multi-modality sensory feedback and using an array of singlemodality stimulators. However, the feedback systems used in these approaches were too bulky to be embedded in prosthesis sockets. In this paper, we propose an electrocutaneous sensory feedback method that is capable of conveying two modalities simultaneously with only one electrode...
July 24, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28741932/tailor-made-luminescent-polymers-through-unusual-metallophilic-interaction-arrays-au%C3%A2-%C3%A2-%C3%A2-au%C3%A2-%C3%A2-%C3%A2-ag%C3%A2-%C3%A2-%C3%A2-ag
#11
María Gil-Moles, M Concepción Gimeno, José M López-de-Luzuriaga, Miguel Monge, M Elena Olmos, David Pascual
A novel and efficient strategy for the synthesis of luminescent polymers bearing metallophilic interactions with unprecedented charge sequences has been designed. For this end suitable basic gold units such as [AuR2](-), bearing perhalophenyl derivatives, and dinuclear acid silver terpyridine species, [Ag2(terpy)2](CF3SO3)2, have been chosen. Their combination originates the polymeric derivatives [{AuR2}2Ag2(terpy)2]n (R = C6F5, C6Cl2F3) or [{Au(C6Cl5)2}Ag(terpy)]n. The change of the perhalophenyl group in the gold complex modulates the strength in the metallophilic contacts and, consequently, the polymer arrays and luminescent properties...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28741898/development-of-a-new-structural-class-of-broadly-acting-hcv-non-nucleoside-inhibitors-leading-to-the-discovery-of-mk-8876
#12
Casey C McComas, Anandan Palani, Wei Chang, M Katharine Holloway, Charles A Lesburg, Peng Li, Nigel Liverton, Peter T Meinke, David B Olsen, Xuanjia Peng, Richard M Soll, Ajay Ummat, Jie Wu, Jin Wu, Nicolas Zorn, Steven W Ludmerer
Studies directed at developing a broadly acting non-nucleoside inhibitor of HCV NS5B led to the discovery of a novel structural class of 5-aryl benzofurans that simultaneously interact with both the palm I and palm II binding regions. An initial candidate was potent in vitro against HCV GT1a and GT1b replicons, and induced multi-log reductions in HCV viral load when orally dosed to chronic GT1 infected chimpanzees. However, in vitro potency losses against clinically relevant GT1a variants prompted a further effort to develop compounds with sustained potency across a broader array of HCV genotypes and mutants...
July 25, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28741705/house-dust-mites-as-potential-carriers-for-ige-sensitisation-to-bacterial-antigens
#13
Sheron Dzoro, Irene Mittermann, Yvonne Resch, Susanne Vrtala, Marion Nehr, Alexander M Hirschl, Gustav Wikberg, Lena Lundeberg, Catharina Johansson, Annika Scheynius, Rudolf Valenta
BACKGROUND: IgE-reactivity to antigens from gram-positive and negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitisation are not fully understood. The analysis of the genome, transcriptome and microbiome of house dust mites (HDM) has shown that S. aureus and E. coli species are abundant bacteria within the HDM microbiome. Therefore, our aim was to investigate if HDM are carriers of bacterial antigens leading to IgE sensitisation in patients suffering from atopic dermatitis...
July 25, 2017: Allergy
https://www.readbyqxmd.com/read/28741462/development-of-a-solid-phase-array-assay-for-the-screening-of-galactose-oxidase-activity-and-for-fast-identification-of-inhibitors
#14
Martin J Weissenborn, Damien P Debecker, Bruno Linclau, Nicolas J Turner, Sabine Flitsch
Galactose oxidase catalyses the highly selective oxidation of terminal galactosides on a wide range of natural glycoconjugates and has found wide applications in biotechnology, particularly in biocatalysis. Here we show that the enzyme is able to oxidise solid gold-SAM surfaces functionalised with galactose. This array platform allows for the fast identification of galactose oxidase substrates and inhibitors from a library of deoxy-fluorinated sugars using MALDI-Tof spectrometry as a label -free read-out method...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28741429/rapid-systemic-delivery-of-zolmitriptan-using-an-adhesive-dermally-applied-microarray
#15
Donald J Kellerman, Mahmoud Ameri, Stewart J Tepper
Adhesive Dermally-Applied Microarray (ADAM) is a device for intracutaneous drug administration consisting of a 3 cm(2) disposable array of drug-coated titanium microprojections on an adhesive backing. It is applied using a low cost, reusable, handheld applicator. Microprojections penetrate the stratum corneum, delivering drug proximal to capillaries with limited likelihood of pain. The pharmacokinetics of zolmitriptan delivery using ADAM was evaluated in 20 healthy volunteers. Median tmax was <20 min, comparable to subcutaneous sumatriptan...
July 25, 2017: Pain Management
https://www.readbyqxmd.com/read/28741350/3d-printed-and-microcontrolled-the-one-hundred-dollars-scanning-electrochemical-microscope
#16
Gabriel Negrão Meloni
The design and fabrication of a versatile and low-cost Electrochemical Scanning Probe Microscope (EC-SPM) is presented. The proposed equipment relies on the use of modern prototyping tools such as 3D printers and microcontroller boards and only a few "off-the-shelf" parts to deliver a simple yet powerful EC-SPM equipment capable of performing simple space resolved electrochemical measurements. The equipment was able to perform space resolved electrochemical measurements using a Platinum ultramicroelectrode (UME) as the working electrode on a Scanning Electrochemical Microscope (SECM) configuration and was used to record approach curves, line scans and array scans over an insulating substrate...
July 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28741142/proteomic-expression-changes-in-large-cerebral-arteries-after-experimental-subarachnoid-hemorrhage-in-rat-are-regulated-by-the-mek-erk1-2-pathway
#17
Anne H Müller, Alistair V G Edwards, Martin R Larsen, Janne Nielsen, Karin Warfvinge, Gro K Povlsen, Lars Edvinsson
Subarachnoid hemorrhage (SAH) is a serious clinical condition where leakage of blood into the subarachnoid space causes an acute rise in intracranial pressure and reduces cerebral blood flow, which may lead to delayed cerebral ischemia and poor outcome. In experimental SAH, we have previously shown that the outcome can be significantly improved by early inhibition of the MAPK/ERK kinase/extracellular signal-regulated kinase (MEK/ERK1/2) pathway. The aim of this study was to apply mass spectrometry to investigate the overall late effects of experimental SAH on cerebrovascular protein expression...
July 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28741107/development-and-optimization-of-a-novel-sample-preparation-method-cored-on-functionalized-nanofibers-mat-solid-phase-extraction-for-the-simultaneous-efficient-extraction-of-illegal-anionic-and-cationic-dyes-in-foods
#18
Feifei Qi, Ningge Jian, Liangliang Qian, Weixin Cao, Qian Xu, Jian Li
A simple and efficient three-step sample preparation method was developed and optimized for the simultaneous analysis of illegal anionic and cationic dyes (acid orange 7, metanil yellow, auramine-O, and chrysoidine) in food samples. A novel solid-phase extraction (SPE) procedure based on nanofibers mat (NFsM) was proposed after solvent extraction and freeze-salting out purification. The preferred SPE sorbent was selected from five functionalized NFsMs by orthogonal experimental design, and the optimization of SPE parameters was achieved through response surface methodology (RSM) based on the Box-Behnken design (BBD)...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28740818/disrupted-latent-inhibition-in-individuals-at-ultra-high-risk-for-developing-psychosis
#19
Michael Kraus, Attilio Rapisarda, Max Lam, Jamie Y J Thong, Jimmy Lee, Mythily Subramaniam, Simon L Collinson, Siow Ann Chong, Richard S E Keefe
The addition of off-the-shelf cognitive measures to established prodromal criteria has resulted in limited improvement in the prediction of conversion to psychosis. Tests that assess cognitive processes central to schizophrenia might better identify those at highest risk. The latent inhibition paradigm assesses a subject's tendency to ignore irrelevant stimuli, a process integral to healthy perceptual and cognitive function that has been hypothesized to be a key deficit underlying the development of schizophrenia...
December 2016: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740757/using-electroretinograms-and-multi-model-inference-to-identify-spectral-classes-of-photoreceptors-and-relative-opsin-expression-levels
#20
Nicolas Lessios
Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question. Existing methods that model the absorption of visual pigments use templates which correspond closely to data from thin cross-sections of photoreceptor cells. However, few modeling approaches use a single framework to incorporate physical parameters of real photoreceptors, which can be fused, and can form vertical tiers...
2017: PeerJ
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