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https://www.readbyqxmd.com/read/29773236/mortality-and-adequacy-of-therapeutic-effort-in-a-tertiary-pediatric-intensive-care-department-an-11-year-review
#1
I Leoz Gordillo, A García-Salido, C Niño Taravilla, G de Lama Caro-Patón, M I Iglesias Bouzas, A Serrano González
No abstract text is available yet for this article.
May 14, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29771812/a-method-for-functional-task-alignment-analysis-of-an-arthrocentesis-simulator
#2
Reid A Adams, Gregory E Gilbert, Lisa A Buckley, Rodolfo Nino Fong, I Carmen Fuentealba, Erika L Little
INTRODUCTION: During simulation-based education, simulators are subjected to procedures composed of a variety of tasks and processes. Simulators should functionally represent a patient in response to the physical action of these tasks. The aim of this work was to describe a method for determining whether a simulator does or does not have sufficient functional task alignment (FTA) to be used in a simulation. METHODS: Potential performance checklist items were gathered from published arthrocentesis guidelines and aggregated into a performance checklist using Lawshe's method...
May 16, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29769741/tropical-meridional-overturning-circulation-observed-by-subsurface-moorings-in-the-western-pacific
#3
Lina Song, Yuanlong Li, Jianing Wang, Fan Wang, Shijian Hu, Chuanyu Liu, Xinyuan Diao, Cong Guan
Meridional ocean current in the northwestern Pacific was documented by seven subsurface moorings deployed at 142°E during August 2014-October 2015. A sandwich structure of the tropical meridional overturning circulation (TMOC) was revealed between 0-6°N that consists of a surface northward flow (0-80 m), a thermocline southward flow (80-260 m; 22.6-26.5 σ θ ), and a subthermocline northward flow (260-500 m; 26.5-26.9 σ θ ). Based on mooring data, along with satellite and reanalysis data, prominent seasonal-to-interannual variations were observed in all three layers, and the equatorial zonal winds were found to be a dominant cause of the variations...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29761134/mild-cognitive-impairment-in-republic-of-georgia
#4
Marina Janelidze, Nina Mikeladze, Nazibrola Bochorishvili, Ann Dzagnidze, Mariam Kapianidze, Nino Mikava, Irene Khatiashvili, Ekaterina Mirvelashvili, Nino Shiukashvili, John Lynch, Zurab Nadareishvili
Objective: The goal of this study was to estimate the prevalence of mild cognitive impairment (MCI) in Georgia. Method: A population-based study was conducted using Georgian version of the Montreal Cognitive Assessment (MoCA) and its cognitive domain index score. Results: Of the initial cohort of 1,000 subjects, 851 met inclusion criteria. The prevalence of MCI was 13.3%, and it was associated with age >65 years (odds ratio [OR] = 4.51, 95% confidence interval [CI] = [3.00, 6.75]), urban residence (OR = 0...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29761039/fine-grained-compositional-analysis-of-port-everglades-inlet-microbiome-using-high-throughput-dna-sequencing
#5
Lauren O'Connell, Song Gao, Donald McCorquodale, Jay Fleisher, Jose V Lopez
Background: Similar to natural rivers, manmade inlets connect inland runoff to the ocean. Port Everglades Inlet (PEI) is a busy cargo and cruise ship port in South Florida, which can act as a source of pollution to surrounding beaches and offshore coral reefs. Understanding the composition and fluctuations of bacterioplankton communities ("microbiomes") in major port inlets is important due to potential impacts on surrounding environments. We hypothesize seasonal microbial fluctuations, which were profiled by high throughput 16S rRNA amplicon sequencing and analysis...
2018: PeerJ
https://www.readbyqxmd.com/read/29760117/inter-decadal-variability-of-phytoplankton-biomass-along-the-coastal-west-antarctic-peninsula
#6
Hyewon Kim, Hugh W Ducklow, Doris Abele, Eduardo M Ruiz Barlett, Anita G J Buma, Michael P Meredith, Patrick D Rozema, Oscar M Schofield, Hugh J Venables, Irene R Schloss
The West Antarctic Peninsula (WAP) is a climatically sensitive region where periods of strong warming have caused significant changes in the marine ecosystem and food-web processes. Tight coupling between phytoplankton and higher trophic levels implies that the coastal WAP is a bottom-up controlled system, where changes in phytoplankton dynamics may largely impact other food-web components. Here, we analysed the inter-decadal time series of year-round chlorophyll- a (Chl) collected from three stations along the coastal WAP: Carlini Station at Potter Cove (PC) on King George Island, Palmer Station on Anvers Island and Rothera Station on Adelaide Island...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760109/shelf-ocean-exchange-and-hydrography-west-of-the-antarctic-peninsula-a-review
#7
REVIEW
C Moffat, M Meredith
The West Antarctic Peninsula (WAP) is a highly productive marine ecosystem where extended periods of change have been observed in the form of glacier retreat, reduction of sea-ice cover and shifts in marine populations, among others. The physical environment on the shelf is known to be strongly influenced by the Antarctic Circumpolar Current flowing along the shelf slope and carrying warm, nutrient-rich water, by cold waters flooding into the northern Bransfield Strait from the Weddell Sea, by an extensive network of glaciers and ice shelves, and by strong seasonal to inter-annual variability in sea-ice formation and air-sea interactions, with significant modulation by climate modes like El Niño-Southern Oscillation and the Southern Annular Mode...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29759309/efficacy-of-stem-cells-in-maxillary-sinus-floor-augmentation-systematic-review-and-meta-analysis
#8
REVIEW
T C Niño-Sandoval, B C Vasconcelos, S L D Moraes, C A A Lemos, E P Pellizzer
The aim of this review was to test the hypothesis of no difference in the efficacy of bone regeneration when using stem cells in maxillary sinus floor augmentation surgery in comparison to other grafts. Nine randomized clinical trials and one follow-up study involving human subjects were identified through a search of the PubMed/MEDLINE, Scopus, Cochrane, and Web of Science databases, supplemented by a hand search. No significant difference between groups was found for the implant survival rate, increase in bone height, marginal bone loss following implant placement, or new bone formation...
May 11, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29758509/potential-health-risks-via-consumption-of-six-edible-shellfish-species-collected-from-piura-peru
#9
I Loaiza, M De Troch, G De Boeck
Scallops and their potential predators were collected in Sechura Bay and in front of the Illescas Reserved Zone (north Peru), during El Niño-Southern Oscillation (ENSO) 2016, and analyzed for the metals chromium (Cr), manganese (Mn), iron (Fe), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), cadmium (Cd) and lead (Pb). This study showed that ~20% of the molluscs exceeded the maximum residual levels (MRLs) for human consumption in inorganic As, while ~30% of the crustaceans did. For Cd, around 10% and 40% of the molluscs and the crustaceans were above the MRLs, respectively...
May 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29756070/reducing-severe-hypoglycaemia-in-hospitalised-patients-with-diabetes-early-outcomes-of-standardised-reporting-and-management
#10
Katherine A Araque, Deepak K Kadayakkara, Nino Gigauri, Diane Sheehan, Sachin Majumdar, Gregory Buller, Clare A Flannery
Background: Severe hypoglycaemic events (HGEs) in hospitalised patients are associated with poor outcomes and prolonged hospitalization. Systematic, coordinated care is required for acute management and prevention of HGEs; however, studies evaluating quality control efforts are scarce. Objective: To investigate the effectiveness of system-based interventions to improve management response to HGEs. Methods: System-based interventions were designed and implemented following a root cause analysis of HGE in adult patients with diabetes from two general medical wards with the highest incidence of HGE...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29751838/association-between-air-pollution-and-suicide-a-time-series-analysis-in-four-colombian-cities
#11
Julián Alfredo Fernández-Niño, Claudia Iveth Astudillo-García, Laura Andrea Rodríguez-Villamizar, Víctor Alfonso Florez-Garcia
BACKGROUND: Recent epidemiological studies have suggested that air pollution could be associated with suicide. However, other studies have criticized these results for being analytically weak and not taking into account potential confounding factors. As such, further studies examining the relationship under diverse contexts are necessary to help clarify this issue. This study explored the association between specific air pollutants (NO2 , SO2 , PM10 , PM2.5 , CO and O3 ) and suicide incidence in four Colombian cities after adjusting for climatic variables and holidays...
May 12, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29749943/experience-with-wearable-cardioverter-defibrillators-at-2-academic-medical-centers
#12
Jordan S Leyton-Mange, William J Hucker, Nino Mihatov, Matthew Reynolds, Christine Albert, Steven A Lubitz, David J Milan
OBJECTIVES: This study sought to characterize the experience in a cohort of patients prescribed a wearable cardioverter-defibrillator (WCD) over a 2-year interval at 2 academic medical centers. BACKGROUND: The WCD is available for patients felt to be at high risk of sudden cardiac death. However, there is a lack of randomized data to guide its use and prescribing patterns vary. METHODS: We retrospectively reviewed indications and therapies of all WCD prescriptions over a 2-year period from 2 large academic medical centers...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29735423/association-of-positive-well-being-with-reduced-cardiac-repolarization-abnormalities-in-the-first-national-health-and-nutrition-examination-survey
#13
Nino Isakadze, Elsayed Z Soliman, Viola Vaccarino, William Whang, Rachel Lampert, J Douglas Bremner, Amit J Shah
BACKGROUND: The mechanisms by which psychological factors may influence possibly arrhythmia risk are not known. We hypothesized that psychological wellness, measured by the General Well-Being Schedule (GBWS), is associated with less repolarization heterogeneity as measured by T-axis. We also explored whether T-axis was a mediator in the relationship of GWBS with adverse cardiac outcomes. METHODS: We studied 5533 adults aged 25-74 years without a history of CVD from NHANES I (National Health and Nutrition Examination Survey) (1971-75)...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29733056/asociaci%C3%A3-n-de-leptina-con-factores-cardiometab%C3%A3-licos-en-escolares-y-adolescentes-con-hiperplasia-suprarrenal-cong%C3%A3-nita
#14
Jessie Nallely Zurita-Cruz, Miguel Ángel Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Rosalba Ferrusca-Ceja, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña
Introducción: En la hiperplasia suprarrenal congénita (HSC), la obesidad, la hiperinsulinemia y los niveles de leptina se encuentran incrementados. Objetivo: Identificar la frecuencia de los factores de riesgo cardiometabólico (FRC) en niños y adolescentes con HSC y explorar la relación con los niveles de leptina. Método: Estudio transversal de 40 pacientes a quienes se realizó somatometría y evaluación de glucosa, insulina, triglicéridos, 17-hidroxiprogesterona, leptina, colesterol HDL y LDL en ayuno...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29731736/coagulation-factor-xii-levels-and-intrinsic-thrombin-generation-in-multiple-sclerosis
#15
Nicole Ziliotto, Marcello Baroni, Sofia Straudi, Fabio Manfredini, Rosella Mari, Erica Menegatti, Rebecca Voltan, Paola Secchiero, Paolo Zamboni, Nino Basaglia, Giovanna Marchetti, Francesco Bernardi
Background: Factor XII (FXII) activation initiates the intrinsic (contact) coagulation pathway. It has been recently suggested that FXII could act as an autoimmunity mediator in multiple sclerosis (MS). FXII depositions nearby dentritic cells were detected in the central nervous system of MS patients and increased FXII activity has been reported in plasma of relapsing remitting and secondary progressive MS patients. FXII inhibition has been proposed to treat MS. Objective: To investigate in MS patients multiple FXII-related variables, including the circulating amount of protein, its pro-coagulant function, and their variation over time...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29731111/kidney-targeted-inhibition-of-protein-kinase-c-%C3%AE-ameliorates-nephrotoxic-nephritis-with-restoration-of-mitochondrial-dysfunction
#16
Nino Kvirkvelia, Malgorzata McMenamin, Marie Warren, Ravirajsinh N Jadeja, Sai Karthik Kodeboyina, Ashok Sharma, Wenbo Zhi, Paul M O'Connor, Raghavan Raju, Rudolf Lucas, Michael P Madaio
To investigate the role of protein kinase C-α (PKC-α) in glomerulonephritis, the capacity of PKC-α inhibition to reverse the course of established nephrotoxic nephritis (NTN) was evaluated. Nephritis was induced by a single injection of nephrotoxic serum and after its onset, a PKC-α inhibitor was administered either systemically or by targeted glomerular delivery. By day seven, all mice with NTN had severe nephritis, whereas mice that received PKC-α inhibitors in either form had minimal evidence of disease...
May 4, 2018: Kidney International
https://www.readbyqxmd.com/read/29727034/physical-activity-during-pregnancy-and-offspring-neurodevelopment-a-systematic-review
#17
REVIEW
Gloria Isabel Niño Cruz, Andrea Ramirez Varela, Inácio Crochemore M da Silva, Pedro Curi Hallal, Iná S Santos
BACKGROUND: Maternal physical activity (PA) during pregnancy could affect offspring's neurodevelopment. However, studies in humans in early childhood are scarce and show inconsistent results. We aimed to review the literature on the association between physical activity during pregnancy and offspring neurodevelopment. METHODS: LILACS, MEDLINE and Web of Science were searched for studies published since 1977. Original studies conducted in humans, without language, country, or study type restriction, were eligible...
May 4, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29723915/causes-of-reduced-leaf-level-photosynthesis-during-strong-el-ni%C3%A3-o-drought-in-a-central-amazon-forest
#18
Victor Alexandre Hardt Ferreira Dos Santos, Marciel José Ferreira, João Victor Figueiredo Cardoso Rodrigues, Maquelle Neves Garcia, João Vitor Barbosa Ceron, Bruce Walker Nelson, Scott Reid Saleska
Sustained drought and concomitant high temperature may reduce photosynthesis and cause tree mortality. Possible causes of reduced photosynthesis include stomatal closure and biochemical inhibition, but their relative roles are unknown in Amazon trees during strong drought events. We assessed the effects of the recent (2015) strong El Niño drought on leaf-level photosynthesis of Central Amazon trees via these two mechanisms. Through four seasons of 2015, we measured leaf gas exchange, chlorophyll a fluorescence parameters, chlorophyll concentration and nutrient content in leaves of 57 upper canopy and understory trees of a lowland terra firme forest on well-drained infertile oxisol...
May 3, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29723436/insights-from-computations-on-the-mechanism-of-reduction-by-ascorbic-acid-of-pt-iv-prodrugs-with-asplatin-and-its-chlorido-and-bromido-analogues-as-model-systems
#19
Emilia Sicilia, Fortuna Ponte, Nino Russo
The elucidation of the mechanism by which the reduction of coordinatively saturated Pt(IV) prodrugs occurs, leading to the release of the two axial ligands, is of foremost importance being the key step for the activation of these anticancer compounds and addressing their synthetic strategies. A systematic DFT computational analysis of the reduction process by small biomolecules, which is supposed to occur by inner- or outer-sphere electron transfer mechanisms, has been undertaken using the recently synthesized Asplatin Pt(IV) complex, c,c,t-[PtCl2(NH3)2(OH)(aspirin)], as model system and L-ascorbic acid as reducing agent...
May 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29720617/modulation-of-the-relationship-between-spring-ao-and-the-subsequent-winter-enso-by-the-preceding-november-ao
#20
Shangfeng Chen, Wen Chen, Bin Yu
Previous studies indicated that the spring Arctic Oscillation (AO) exerts significant influences on the subsequent winter El Niño-Southern Oscillation (ENSO). This analysis suggests that the spring AO-ENSO linkage is highly modulated by its preceding November AO. When November and the subsequent spring AO indices are in phase, the spring AO has a pronounced influence on ENSO. However, when the November and spring AO indices are out of phase, the spring AO-ENSO connection disappears. Modulation of the November AO on the spring AO-ENSO connection is mainly through the constructive and destructive superposition of the November and spring AO associated sea surface temperature (SST) anomalies in the tropical central-eastern Pacific in spring and summer, as well as the SST anomalies developed further in the tropical Pacific via the positive air-sea feedback...
May 2, 2018: Scientific Reports
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