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https://www.readbyqxmd.com/read/29471506/a-translational-silencing-function-of-mcpip1-regnase-1-specified-by-the-target-site-context
#1
Gesine Behrens, Reinhard Winzen, Nina Rehage, Anneke Dörrie, Monika Barsch, Anne Hoffmann, Jörg Hackermüller, Christopher Tiedje, Vigo Heissmeyer, Helmut Holtmann
The expression of proteins during inflammatory and immune reactions is coordinated by post-transcriptional mechanisms. A particularly strong suppression of protein expression is exerted by a conserved translational silencing element (TSE) identified in the 3' UTR of NFKBIZ mRNA, which is among the targets of the RNA-binding proteins Roquin-1/2 and MCPIP1/Regnase-1. We present evidence that in the context of the TSE MCPIP1, so far known for its endonuclease activity toward mRNAs specified by distinct stem-loop (SL) structures, also suppresses translation...
February 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471387/heavy-cannabis-use-associated-with-reduction-in-activated-and-inflammatory-immune-cell-frequencies-in-antiretroviral-therapy-treated-human-immunodeficiency-virus-infected-individuals
#2
Jennifer A Manuzak, Toni M Gott, Jay S Kirkwood, Ernesto Coronado, Tiffany Hensley-McBain, Charlene Miller, Ryan K Cheu, Ann C Collier, Nicholas T Funderburg, Jeffery N Martin, Michael C Wu, Nina Isoherranen, Peter W Hunt, Nichole R Klatt
Background: Cannabis is a widely used drug in the United States, and the frequency of cannabis use in the human immunodeficiency virus (HIV)-infected population is disproportionately high. Previous human and macaque studies suggest that cannabis may have an impact on plasma viral load; however, the relationship between cannabis use and HIV-associated systemic inflammation and immune activation has not been well defined. Methods: The impact of cannabis use on peripheral immune cell frequency, activation, and function was assessed in 198 HIV-infected, antiretroviral-treated individuals by flow cytometry...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29470920/long-term-microevolution-of-pseudomonas-aeruginosa-differs-between-mildly-and-severely-affected-cystic-fibrosis-lungs
#3
Jens Klockgether, Nina Cramer, Sebastian Fischer, Lutz Wiehlmann, Burkhard Tümmler
RATIONALE: The chronic airway infections with Pseudomonas aeruginosa determine morbidity in most individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs which provides the rare opportunity to study the long-term within-host evolution of a bacterial airway pathogen. OBJECTIVES: To resolve the genetic adaptation of P. aeruginosa in CF lungs from the onset of colonization until the patient's death or permanent replacement by another P...
February 22, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29469932/high-control-rates-of-proton-and-carbon-ion-beam-treatment-with-intensity-modulated-active-raster-scanning-in-101-patients-with-skull-base-chondrosarcoma-at-the-heidelberg-ion-beam-therapy-center
#4
Matthias Mattke, Kira Vogt, Nina Bougatf, Thomas Welzel, Jan Oelmann-Avendano, Henrik Hauswald, Alexandra Jensen, Malte Ellerbrock, Oliver Jäkel, Thomas Haberer, Klaus Herfarth, Jürgen Debus, Matthias Uhl
BACKGROUND: The current study compares the results of irradiation with protons and irradiation with carbon ions via a raster scan technique in patients with G1 and G2 skull base chondrosarcomas. METHODS: Between 2009 and 2014, a total of 101 patients (40 men and 61 women) with a median age of 44 years (range, 19-77 years) were irradiated with carbon ions (79 patients) or protons (22 patients) via a raster scan technique at the Heidelberg Ion Beam Therapy Center...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29469014/effect-of-mineral-status-and-glucocorticoid-use-on-bone-mineral-density-in-patients-with-crohn-s-disease
#5
Nayane R Pierote, Amanda F Braz, Susy L Barros, José M Moita Neto, José Miguel L Parente, Maria da Cruz M Silva, Mayara S Beserra, Nina Rosa M Soares, Dilina N Marreiro, Nadir do Noscimento Nogueira
OBJECTIVES: Crohn's disease (CD) is a condition that is characterized by chronic inflammation. The presence of multifactorial pathogenesis that results from inflammation is associated with low micronutrient consumption and glucocorticoid use, which may be related to bone health. This study aimed to evaluate the relationship between dietary mineral intake and glucocorticoid use in bone mineral density (BMD) in patients with CD. METHODS: A cross-sectional study of 62 patients with CD ages 20 y to 40 y measured their macro- and micronutrient intake with a 3-d food record...
November 27, 2017: Nutrition
https://www.readbyqxmd.com/read/29468942/perceptions-of-determinants-of-condom-use-behaviors-among-male-clients-of-female-sex-workers-in-indonesia-a-qualitative-inquiry
#6
Nelsensius Klau Fauk, Christina Yeni Kustanti, Debora Shinta Liana, Nina Indriyawati, Rik Crutzen, Lillian Mwanri
This study aimed to explore perceived determinants of condom use behaviors among male clients of female commercial sex workers (FCSWs) in Belu and Malaka districts, Indonesia. One-on-one in-depth interviews guided by the Health Belief Model (HBM) were used to collect the data from participants ( n = 42). The Framework analysis for qualitative data was employed to analyze the data. Results demonstrated several factors associated with lack of and inconsistent condom use among the participants. They included self-perceived risk of contracting HIV infection, knowledge of the severity of HIV illness and its impacts, and condom use: its benefits and its influencing factors...
February 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29468631/high-dose-melphalan-based-sequential-conditioning-chemotherapy-followed-by-allogeneic-haematopoietic-stem-cell-transplantation-in-adult-patients-with-relapsed-or-refractory-acute-myeloid-leukaemia
#7
Nina K Steckel, Christoph Groth, Jan-Henrik Mikesch, Rudolf Trenschel, Hellmut Ottinger, Lambros Kordelas, Carsten Mueller-Tidow, Christoph Schliemann, Christian Reicherts, Joern C Albring, Gerda Silling, Eva Schmidt, Wolfgang E Berdel, Georg Lenz, Markus Ditschkowski, Dietrich W Beelen, Matthias Stelljes
Considering the unsatisfactory results of salvage therapies for patients with relapsed/refractory acute myeloid leukaemia (R/R-AML), their value before allogeneic haematopoietic stem cell transplantation (HSCT) remains questionable. However, direct allogeneic HSCT following established conditioning regimens applied in patients with R/R-AML during active disease has been equally disappointing. In this retrospective observational study, high-dose melphalan, as part of a sequential preparative regimen, followed by a total body irradiation (4 × 2 Gy)-based or a treosulfan-based dose-adapted conditioning therapy for allogeneic HSCT was administered to 292 adult patients (median age 56 years, range 17-74) with primary refractory (144 patients), secondary refractory (97 patients) or relapsed AML (51 patients)...
February 21, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29467518/is-umbilical-coiling-genetically-determined
#8
Nina K Ayala, Linda M Ernst, Emily S Miller
OBJECTIVE: Abnormal umbilical cord coiling is associated with adverse perinatal outcomes; however, the etiology of the umbilical coiling pattern is poorly understood. STUDY DESIGN: Retrospective cohort of all twin deliveries >20 weeks in 2014. Pregnancies were dichotomized by chorionicity and the umbilical coiling index (UCI) and placental cord insertion location were compared. In cases with one or both cords hypercoiled, the direction and pattern of coiling were compared by chorionicity...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467373/deep-learning-based-tissue-analysis-predicts-outcome-in-colorectal-cancer
#9
Dmitrii Bychkov, Nina Linder, Riku Turkki, Stig Nordling, Panu E Kovanen, Clare Verrill, Margarita Walliander, Mikael Lundin, Caj Haglund, Johan Lundin
Image-based machine learning and deep learning in particular has recently shown expert-level accuracy in medical image classification. In this study, we combine convolutional and recurrent architectures to train a deep network to predict colorectal cancer outcome based on images of tumour tissue samples. The novelty of our approach is that we directly predict patient outcome, without any intermediate tissue classification. We evaluate a set of digitized haematoxylin-eosin-stained tumour tissue microarray (TMA) samples from 420 colorectal cancer patients with clinicopathological and outcome data available...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467341/retraction-nucleophagy-in-human-disease-beyond-the-physiological-role-tohoku-j-exp-med-2018-244-1-75-81-doi-10-1620-tjem-244-75-review
#10
Ming Zhou, Hongwen Ji, Nian Fu, Linxi Chen, Yong Xia
Retracted Review article: Nucleophagy in Human Disease: Beyond the Physiological Role. [Tohoku J. Exp. Med., 2018, 244 (1), 75-81. doi: 10.1620/tjem.244.75.]The above Review article was published online on January 27, 2018. Soon after its publication (on February 1, 2018), Dr. Nian Fu and Prof. Linxi Chen informed the Editor-in-Chief, The Tohoku Journal of Experimental Medicine (TJEM), about serious violation of publication ethics. Indeed, Dr. Nian Fu and Prof. Linxi Chen were astonished to find their names as coauthors of this Review article, because they were not involved in the submission process of this Review article and they do not know any of other coauthors...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29466858/release-of-terminal-alkynes-via-tandem-photodeprotection-decarboxylation-of-o-nitrobenzyl-arylpropiolates-in-a-flow-microchannel-reactor
#11
Behabitu Ergette Tebikachew, Karl Börjesson, Nina Kann, Kasper Moth-Poulsen
Photocleavable protecting groups (PPGs) offer a complementary protection paradigm compared to traditional protection groups. Herein, o-nitrobenzyl (NB) PPG was employed to protect a variety of arylpropiolic acids. Upon a cascade of light-triggered photodeprotection in a microchannel reactor (residence time 100-500 s), followed by Cu-catalyzed decarboxylation at 60 °C, the NB-protected arylpropiolic acid afforded a terminal alkyne. This terminal alkyne was further reacted in situ with an azide via click chemistry to yield a 1,2,3-triazole in a one-pot reaction...
February 21, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29466686/divergent-effects-of-cold-water-immersion-versus-active-recovery-on-skeletal-muscle-fiber-type-and-angiogenesis-in-young-men
#12
Randall F D'Souza, Nina Zeng, James F Markworth, Vandre Casagrande Figueiredo, Llion Arwyn Roberts, Truls Raastad, Jeff S Coombes, Jonathan M Peake, David Cameron-Smith, Cameron J Mitchell
Resistance training (RT) increases muscle fiber size and induces angiogenesis to maintain capillary density. Cold water immersion (CWI), a common post-exercise recovery modality may improve acute recovery, but it attenuates muscle hypertrophy compared with active recovery (ACT). It is unknown if CWI following RT alters muscle fiber type expression or angiogenesis. Twenty-one men strength trained for 12 weeks, with either 10 min of CWI (n=11) or ACT (n=10) performed following each session. Vastus lateralis biopsies were collected at rest before and after training...
February 21, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29466460/high-intra-specific-variation-in-avian-body-condition-responses-to-climate-limits-generalisation-across-species
#13
Nina McLean, Henk P van der Jeugd, Martijn van de Pol
It is generally assumed that populations of a species will have similar responses to climate change, and thereby that a single value of sensitivity will reflect species-specific responses. However, this assumption is rarely systematically tested. High intraspecific variation will have consequences for identifying species- or population-level traits that can predict differences in sensitivity, which in turn can affect the reliability of projections of future climate change impacts. We investigate avian body condition responses to changes in six climatic variables and how consistent and generalisable these responses are both across and within species, using 21 years of data from 46 common passerines across 80 Dutch sites...
2018: PloS One
https://www.readbyqxmd.com/read/29466429/population-nutrikinetics-of-green-tea-extract
#14
Catharina Scholl, Anna Lepper, Thorsten Lehr, Nina Hanke, Katharina Luise Schneider, Jürgen Brockmöller, Thomas Seufferlein, Julia Carolin Stingl
Green tea polyphenols may contribute to the prevention of cancer and other diseases. To learn more about the pharmacokinetics and interindividual variation of green tea polyphenols after oral intake in humans we performed a population nutrikinetic study of standardized green tea extract. 84 healthy participants took green tea extract capsules standardized to 150 mg epigallocatechin-gallate (EGCG) twice a day for 5 days. On day 5 catechin plasma concentrations were analyzed using non-compartmental and population pharmacokinetic methods...
2018: PloS One
https://www.readbyqxmd.com/read/29465286/genetic-association-of-single-nucleotide-polymorphisms-of-fzd4-and-bdnf-genes-with-retinopathy-of-prematurity
#15
Zora Lasabova, Andrea Stanclova, Marian Grendar, Silvia Mikolajcikova, Andrea Calkovska, Nina Lenhartova, Peter Ziak, Katarina Matasova, Martin Caprnda, Peter Kruzliak, Mirko Zibolen
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial disease occurring in preterm neonates, caused by incorrect development of retinal blood vessels. It has been suggested that, in addition to gestational age, weight, and oxygen supplementation, genetic factors can play a role in the pathogenesis of ROP. METHODS: In the present prospective study, 97 neonates were enrolled based on the gestational age and weight, and genomic DNA from patients diagnosed with ROP and premature newborns without ROP was collected...
February 21, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29464298/correction-to-catheter-retention-as-a-consequence-rather-than-a-cause-of-unfavorable-outcome-in-candidemia
#16
Lauro Damonti, Véronique Erard, Jorge Garbino, Jacques Schrenzel, Stefan Zimmerli, Konrad Mühlethaler, Alexander Imhof, Reinhard Zbinden, Jan Fehr, Katia Boggian, Thomas Bruderer, Ursula Flückiger, Reno Frei, Christina Orasch, Anna Conen, Nina Khanna, Thomas Bregenzer, Jacques Bille, Frédéric Lamoth, Oscar Marchetti, Pierre-Yves Bochud
In the original publication the members of the FUNGINOS network were provided in such a way that they could not be indexed as collaborators on PubMed.
February 20, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29464050/assessing-tumor-molecular-profiling-to-guide-treatments-for-patients-with-advanced-female-genital-tract-malignancy
#17
Philip Carter, Costi Alifrangis, Biancastella Cereser, Pramodh Chandrasinghe, Lisa Del Bel Belluz, Christina Fotopoulou, Andreja Frilling, Thomas Herzog, Nina Moderau, Neha Tabassum, Jonathan Krell, Justin Stebbing
Tumor molecular profiling has enabled selection of targeted therapies in a host of solid tumors. Here we used a retrospective clinical cohort, to evaluate the benefit of tailoring treatments for female genital tract malignancy, using tumor molecular profiles. Clinical outcome data for 112 patients was retrospectively separated into two groups. These either followed a matched treatment plan that incorporated at least one drug recommended according to their tumor profile and none that were expected to have no benefit (64 patients), or was unmatched with suggested treatments and received at least one drug that was anticipated to lack benefit for that tumor (48 patients)...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463660/novel-segment-and-host-specific-patterns-of-enteroaggregative-escherichia-coli-adherence-to-human-intestinal-enteroids
#18
Anubama Rajan, Lucy Vela, Xi-Lei Zeng, Xiaomin Yu, Noah Shroyer, Sarah E Blutt, Nina M Poole, Lily G Carlin, James P Nataro, Mary K Estes, Pablo C Okhuysen, Anthony W Maresso
Enteroaggregative Escherichia coli (EAEC) is an important diarrheal pathogen and a cause of both acute and chronic diarrhea. It is a common cause of pediatric bacterial diarrhea in developing countries. Despite its discovery in 1987, the intestinal tropism of the pathogen remains unknown. Cell lines used to study EAEC adherence include the HEp-2, T-84, and Caco-2 lines, but they exhibit abnormal metabolism and large variations in gene expression. Animal models either do not faithfully manifest human clinical symptoms or are cumbersome and expensive...
February 20, 2018: MBio
https://www.readbyqxmd.com/read/29463214/genome-mining-for-peptidases-in-heat-tolerant-and-mesophilic-fungi-and-putative-adaptations-for-thermostability
#19
Tássio Brito de Oliveira, Cene Gostinčar, Nina Gunde-Cimerman, Andre Rodrigues
BACKGROUND: Peptidases (EC 3.4) consist of a large group of hydrolytic enzymes that catalyze the hydrolysis of proteins accounting for approximately 65% of the total worldwide enzyme production. Peptidases from thermophilic fungi have adaptations to high temperature that makes them adequate for biotechnological application. In the present study, we profiled the genomes of heat-tolerant fungi and phylogenetically related mesophilic species for genes encoding for peptidases and their putative adaptations for thermostability...
February 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29462974/inadequate-iodine-intake-in-population-groups-defined-by-age-life-stage-and-vegetarian-dietary-practice-in-a-norwegian-convenience-sample
#20
Anne Lise Brantsæter, Helle Katrine Knutsen, Nina Cathrine Johansen, Kristine Aastad Nyheim, Iris Erlund, Helle Margrete Meltzer, Sigrun Henjum
Inadequate iodine intake has been identified in populations considered iodine replete for decades. The objective of the current study is to evaluate urinary iodine concentration (UIC) and the probability of adequate iodine intake in subgroups of the Norwegian population defined by age, life stage and vegetarian dietary practice. In a cross-sectional survey, we assessed the probability of adequate iodine intake by two 24-h food diaries and UIC from two fasting morning spot urine samples in 276 participants. The participants included children ( n = 47), adolescents ( n = 46), adults ( n = 71), the elderly ( n = 23), pregnant women ( n = 45), ovo-lacto vegetarians ( n = 25), and vegans ( n = 19)...
February 17, 2018: Nutrients
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