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https://www.readbyqxmd.com/read/28724198/direct-and-topoisomerase-ii-mediated-dna-damage-by-bis-3-chloropiperidines-the-importance-of-being-an-earnest-g
#1
Alice Sosic, Ivonne Zuravka, Nina-Katharina Schmitt, Angelica Miola, Richard Göttlich, Dan Fabris, Barbara Gatto
Bis-3-chloropiperidines are a new class of DNA-active compounds capable of alkylating nucleobases and inducing strand cleavage. In this report, we investigated the reactivity of these mustard-based agents with both single- and double-stranded DNA constructs. Polyacrylamide gel electrophoresis (PAGE) and electrospray ionization mass spectrometry (ESI-MS) were employed to obtain valuable insights into their mechanism at the molecular level and to investigate their time- and concentration-dependence. The results revealed the preferential formation of mono- and bifunctional adducts at nucleophilic guanine sites...
July 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28723172/periodically-patterned-au-tio2-heterostructures-for-photoelectrochemical-sensor
#2
Limin Guo, Zhao Li, Kyle Marcus, Steven Navarro, Kun Liang, Le Zhou, Prabhu Doss Mani, Stephen J Florczyk, Kevin R Coffey, Nina Orlovskaya, Yong-Ho Sohn, Yang Yang
Periodically patterned Au nanorods in TiO2 nanocavities (Au NRs@TiO2) were fabricated via magnetron sputtering followed by a thermal dewetting process. This innovative Au NRs@TiO2 heterostructure was used as a plasmonic sensing platform for photoelectrochemical detection of glucose and lactose. This Au NRs@TiO2 patterned heterostructure possesses superior sensing properties to other Au nanoparticle-based sensors because (i) localized surface plasmon resonance (LSPR) generated at Au/TiO2 interfaces enhanced sensitivity of glucose (lactose) amperometric detection; (ii) periodic Au nanocrystals in TiO2 nanocavities accelerated charge separation and transfer rate, especially under monochromatic blue light irradiation; (iii) discrete planar architectures comprising Au NRs immobilized on TiO2 substrates significantly improved stability and reusability of the sensors...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722340/a-novel-small-molecule-inhibitor-of-prion-replication-and-mutant-prion-protein-toxicity
#3
Tania Massignan, Valeria Sangiovanni, Silvia Biggi, Claudia Stincardini, Saioa R Elezgarai, Giulia Maietta, Ivan A Andreev, Nina K Ratmanova, Dmitry S Belov, Evgeny R Lukyanenko, Grigory M Belov, Maria Letizia Barreca, Andrea Altieri, Alexander V Kurkin, Emiliano Biasini
Prion diseases are a class of neurodegenerative disorders characterized by the accumulation in the brain of a self-replicating, misfolded isoform (PrPSc) of the cellular prion protein (PrPC), a cell-surface glycoprotein of uncertain function. Emerging evidence suggests that PrPC may passively serve as a substrate for the replication of PrPSc, and actively transduce its toxic effects to neuronal cells. The vast majority of previous drug screening campaigns have only targeted PrPSc replication, with largely unsuccessful results...
July 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28722152/pilot-of-the-boost-a%C3%A2-an-online-transition-planning-program-for-adolescents-with-autism
#4
Megan Hatfield, Nina Murray, Marina Ciccarelli, Torbjörn Falkmer, Marita Falkmer
BACKGROUND: Many adolescents with autism face difficulties with the transition from high school into post-school activities. The Better OutcOmes & Successful Transitions for Autism (BOOST-A™) is an online transition planning program which supports adolescents on the autism spectrum to prepare for leaving school. This study describes the development of the BOOST-A™ and aimed to determine the feasibility and viability of the program. METHODS: Two pilot studies were conducted...
July 19, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28720669/muc1-mediated-metabolic-alterations-regulate-response-to-radiotherapy-in-pancreatic-cancer
#5
Venugopal Gunda, Joshua J Souchek, Jaime Abrego, Surendra K Shukla, Gennifer D Goode, Enza Vernucci, Aneesha Dasgupta, Nina CHaika, Ryan J King, Sicong Li, Shuo Wang, Fang Yu, Tadayoshi Bessho, Chi Lin, Pankaj K Singh
Purpose: MUC1, an oncogene overexpressed in multiple solid tumors including pancreatic cancer, reduces overall survival and imparts resistance to radiation and chemotherapies. We previously identified that MUC1 facilitates growth promoting metabolic alterations in pancreatic cancer cells. The present study investigates the role of MUC1-mediated metabolism in radiation resistance of pancreatic cancer by utilizing cell lines and in vivo models. <p>Experimental design: We used MUC1 knockdown and overexpressed cell line models for evaluating the role of MUC1-mediated metabolism in radiation resistance through in vitro cytotoxicity, clonogenicity, DNA damage response and metabolomic evaluations...
July 18, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28720148/multifocal-gastric-adenocarcinoma-in-a-patient-with-lrba-deficiency
#6
Nina Bratanič, Jernej Kovač, Katka Pohar, Katarina Trebušak Podkrajšek, Alojz Ihan, Tadej Battelino, Magdalena Avbelj Stefanija
BACKGROUND: Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency is characterized by primary immunodeficiency and autoimmunity. Cancer may present another feature of LRBA deficiency. We describe a case history of a young adult with LRBA deficiency and two independent malignancies. METHODS: Family-trio whole exome sequencing with unbiased phenotype ontology approach was used for identification of causative mutations of a primary immune deficiency disorder...
July 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28719544/postoperative-pyoderma-gangrenosum-in-children-the-case-report-of-a-13-year-old-boy-with-pyoderma-gangrenosum-after-hip-reconstruction-surgery-and-a-review-of-the-literature
#7
Nina Berger, Michael Ebenhoch, Maya Salzmann
BACKGROUND: Postoperative pyoderma gangrenosum (PG) is a neutrophilic dermatosis and pathergic reaction at surgical sites. Reports of children with postoperative PG are rare in the literature. METHODS: We report the case of a 13-year-old boy without any known preexisting illnesses, who developed severe systemic response and wound deterioration after elective hip reconstruction surgery. The working diagnosis of necrotizing fasciitis was later determined to be postoperative PG...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28719278/evaluation-of-the-field-performance-of-immunocard-stat-%C3%A2-rapid-diagnostic-test-for-rotavirus-in-dadaab-refugee-camp-and-at-the-kenya-somalia-border
#8
Maurice Ope, Raymond Nyoka, Ahmed Unshur, Fredrick O Oyier, Shafe A Mowlid, Brian Owino, Steve B Ochieng, Charles I Okello, Joel M Montgomery, Burton Wagacha, Aleksandar Galev, Abdikadir Abdow, Mathew D Esona, Jacqueline Tate, David Fitter, Susan T Cookson, Balajee Arunmozhi, Nina Marano
AbstractRotavirus commonly causes diarrhea in children, leading to hospitalization and even death. Rapid diagnostic tests are feasible alternatives for determining rotavirus outbreaks in refugee camps that have inadequate laboratory capacity. We evaluated the field performance of ImmunoCard STAT!(®) Rotavirus (ICS-RV) in Dadaab Refugee Camp and at the Kenya-Somalia border. From May to December 2014, we prospectively enrolled children aged < 5 years hospitalized with acute diarrhea, defined as ≥ 3 episodes of loose stool in 24 hours for < 7 days...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718870/-motivational-goals-and-couple-relationship-quality-in-a-sample-of-individuals-with-infertility
#9
Misa Yamanaka-Altenstein, Emanuel Henrich, Nina Heinrichs
3,5-16,6% of couples worldwide with childwish suffer from infertility, and about 20% thereof show clinically relevant psychological symptoms. Until now it remained unclear, up to which extent motivational factors are associated with psychological distress when suffering from infertility. The goal of this study was to assess individual motivational factors in a sample of infertile people, and to explore their effect on psychological distress. Additionally, the role of couple relationship quality as a dyadic predictor was to be examined...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718868/-implicit-associations-with-death-first-validation-of-the-german-version-of-the-suicide-implicit-association-test-suicide-iat
#10
Dajana Rath, Nina Hallensleben, Heide Glaesmer, Lena Spangenberg, Maria Strauss, Anette Kersting, Tobias Teismann, Thomas Forkmann
Nock, Park, Finn, et al. 1 developed an implicit association test for suicide (suicide IAT) measuring the implicit association between 'death' and 'self'. They demonstrated that psychiatric patients, who already attempted suicide, showed stronger implicit associations with 'death' than with 'life' compared to patients without suicide attempt history. The present study had 2 aims: (1) to present a new German version of the suicide IAT and provide its first validation and (2) to investigate how implicit associations (suicide IAT) relate to suicidal ideation and behaviour, well-known risk factors such as depressiveness and hopelessness, and central concepts of the Interpersonal Theory of Suicide 2, Thwarted Belongingness and Perceived Burdensomeness...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718320/oral-prednisolone-for-4-days-does-not-increase-exercise-tolerance-in-men-with-copd
#11
S L Karlsson, V Backer, Nina Skavlan Godtfredsen
One of the primary objectives in management of chronic obstructive pulmonary disease (COPD) is preventing decrease in lung function and reducing the annual number of acute exacerbations of COPD (AECOPD). An oral course of systemic corticosteroids is a commonly used treatment in AECOPD. We hypothesize that this treatment also increases exercise performance and decreases muscle fatigue. In a randomized double-blinded, parallel, placebo-controlled trial, we investigated 14 men (8 on prednisolone 37.5 mg vs. 6 on placebo) with severe and very severe COPD...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28717889/combined-arthroscopically-assisted-coraco-and-acromioclavicular-stabilization-of-acute-high-grade-acromioclavicular-joint-separations
#12
Carmen Hann, Natascha Kraus, Marvin Minkus, Nina Maziak, Markus Scheibel
PURPOSE AND HYPOTHESIS: Due to high rate of persisting dynamic posterior translation (DPT) following isolated coracoclavicular double-button technique for reconstruction of the acromioclavicular (AC) joint reported in the literature, an additional acromioclavicular cerclage was added to the procedure. The aim of this study was to evaluate the clinical and radiological results of patients with high-grade AC-joint instability treated with a double TightRope technique with an additional percutaneous acromioclavicular cerclage...
July 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28717854/pharmaceutically-treated-anxiety-but-not-depression-prior-to-cancer-diagnosis-predicts-the-onset-of-cardiovascular-disease-among-breast-cancer-survivors
#13
Dounya Schoormans, Lonneke van de Poll-Franse, Pauline Vissers, Myrthe P P van Herk-Sukel, Susanne S Pedersen, Nina Rottmann, Trine Horsbøl, Susanne Dalton, Johan Denollet
PURPOSE: To examine the associations between pharmaceutically treated anxiety and depression present in the year prior to breast cancer diagnosis and the risk of incident cardiovascular disease (CVD), while controlling for traditional cardiovascular risk factors and clinical characteristics in a population-based observational study. METHODS: Adult 1-year breast cancer survivors (n = 7227), diagnosed between 01-01-1999 and 12-31-2010, with no history of CVD, were selected from the Netherlands Cancer Registry...
July 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28717231/a-connection-from-stratospheric-ozone-to-el-ni%C3%A3-o-southern-oscillation
#14
Desmond Manatsa, Geoffrey Mukwada
We use reanalysis and observational data to link the lower stratospheric ozone regulation of the ultraviolet radiation (UV-B) component of solar energy to ENSO modulation. Results indicate that during ENSO extremes, the Walker Circulation (WC) and Brewer Dobson Circulation are related to lower stratospheric ozone alterations east of the date line over the Pacific. These in turn are linked to upper tropospheric anomalous dipole temperature patterns on either side of the equator. The ensuing changes in geopotential height values do not only drive equatorial zonal wind anomalies in the upper troposphere that are reversed at the equatorial surface, but also impact on the intensity of the South Pacific High circulation...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717132/fiber-cavities-with-integrated-mode-matching-optics
#15
Gurpreet Kaur Gulati, Hiroki Takahashi, Nina Podoliak, Peter Horak, Matthias Keller
In fiber based Fabry-Pérot Cavities (FFPCs), limited spatial mode matching between the cavity mode and input/output modes has been the main hindrance for many applications. We have demonstrated a versatile mode matching method for FFPCs. Our novel design employs an assembly of a graded-index and large core multimode fiber directly spliced to a single mode fiber. This all-fiber assembly transforms the propagating mode of the single mode fiber to match with the mode of a FFPC. As a result, we have measured a mode matching of 90% for a cavity length of ~400 μm...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716066/erratum-to-more-complications-in-uncemented-compared-to-cemented-hemiarthroplasty-for-displaced-femoral-neck-fractures-a-randomized-controlled-trial-of-201-patients-with-one-year-follow-up
#16
Sophie Moerman, Nina M C Mathijssen, Dieu D Niesten, Roeland Riedijk, Willard J Rijnberg, Sander Koëter, Keetie Kremers van de Hei, Wim E Tuinebreijer, Tim L Molenaar, Rob G H H Nelissen, Anne J H Vochteloo
No abstract text is available yet for this article.
July 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28715499/helicobacter-pylori-modulates-host-cell-responses-by-cagt4ss-dependent-translocation-of-an-intermediate-metabolite-of-lps-inner-core-heptose-biosynthesis
#17
Saskia C Stein, Eugenia Faber, Simon H Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells. Responsible in part for this signaling is the cag pathogenicity island (cagPAI) that codetermines the risk for pathological sequelae of an H. pylori infection such as gastric cancer. The Cag type IV secretion system (CagT4SS), encoded on the cagPAI, can translocate various molecules into cells, the effector protein CagA, peptidoglycan metabolites and DNA...
July 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28714926/a-protein-diet-score-including-plant-and-animal-protein-investigating-the-association-with-hba1c-and-egfr-the-preview-project
#18
Grith Møller, Diewertje Sluik, Christian Ritz, Vera Mikkilä, Olli T Raitakari, Nina Hutri-Kähönen, Lars O Dragsted, Thomas M Larsen, Sally D Poppitt, Marta P Silvestre, Edith J M Feskens, Jennie Brand-Miller, Anne Raben
Higher-protein diets have been advocated for body-weight regulation for the past few decades. However, the potential health risks of these diets are still uncertain. We aimed to develop a protein score based on the quantity and source of protein, and to examine the association of the score with glycated haemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR). Analyses were based on three population studies included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World): NQplus, Lifelines, and the Young Finns Study...
July 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28714517/overexpression-of-the-erythropoietin-receptor-in-rama-37-breast-cancer-cells-alters-cell-growth-and-sensitivity-to-tamoxifen
#19
Lenka Ilkovičová, Nina Trošt, Erika Szentpéteriová, Peter Solár, Radovan Komel, Nataša Debeljak
Erythropoietin (EPO) is the main regulator of erythropoiesis, and its receptor (EPOR) is expressed in various tissues, including tumors. Expression of EPOR in breast cancer tissue has been shown to correlate with expression of the estrogen receptor (ER). However, EPOR promotes proliferation in an EPO-independent manner. In patients with breast cancer, EPOR is associated with impaired tamoxifen response in ER-positive tumors, but not in ER-negative tumors. Furthermore, a positive correlation between EPOR/ER status and increased local cancer recurrence has been demonstrated, and EPOR expression is associated with G-protein coupled ER (GPER)...
August 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713448/survival-of-node-negative-breast-cancer-patients-treated-at-the-university-medical-centre-maribor-in-the-period-2000-2009
#20
Nina Fokter Dovnik, Darja Arko, Nina Čas Sikošek, Iztok Takač
INTRODUCTION: Breast cancer is increasingly diagnosed in the early stages without regional nodal involvement. The aim of the present study was to determine the 5-year overall (OS) and breast cancer specific survival (BCSS) for patients with node-negative breast cancer treated at the University Medical Centre Maribor, and compare it with survival at the national level. METHODS: Medical records were searched for information on patients with lymph node-negative invasive breast cancer who received primary treatment at the University Medical Centre Maribor in the period 2000-2009...
September 2017: Zdravstveno Varstvo
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