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https://www.readbyqxmd.com/read/29045914/suicide-exposures-and-bereavement-among-american-adults-evidence-from-the-2016-general-social-survey
#1
William Feigelman, Julie Cerel, John L McIntosh, David Brent, Nina Gutin
BACKGROUND: We investigated lifetime suicide exposures and bereavement among a representative sample of American adults from the 2016 General Social Survey. METHODS: Questions on lifetime suicide exposures, bereavement and mental health status were administered to 1432 respondents. Suicide exposed and bereaved respondents were compared to non-exposed respondents on three different measures of mental health functioning with cross tabulations and means comparison tests...
October 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29045908/long-term-exposure-to-residential-railway-and-road-traffic-noise-and-risk-for-diabetes-in-a-danish-cohort
#2
Nina Roswall, Ole Raaschou-Nielsen, Steen Solvang Jensen, Anne Tjønneland, Mette Sørensen
BACKGROUND: Road traffic noise exposure has been found associated with diabetes incidence. Evidence for an association between railway noise exposure is less clear, as large studies with detailed railway noise modelling are lacking. PURPOSE: To investigate the association between residential railway noise and diabetes incidence, and to repeat previous analyses on road traffic noise and diabetes with longer follow-up time. METHODS: Among 50,534 middle-aged Danes enrolled into the Diet, Cancer and Health cohort from 1993 to 97, we identified 5062 cases of incident diabetes during a median follow-up of 15...
October 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/29045905/transcriptional-reprogramming-during-effector-to-memory-transition-renders-cd4-t-cells-permissive-for-latent-hiv-1-infection
#3
Liang Shan, Kai Deng, Hongbo Gao, Sifei Xing, Adam A Capoferri, Christine M Durand, S Alireza Rabi, Gregory M Laird, Michelle Kim, Nina N Hosmane, Hung-Chih Yang, Hao Zhang, Joseph B Margolick, Linghua Li, Weiping Cai, Ruian Ke, Richard A Flavell, Janet D Siliciano, Robert F Siliciano
The latent reservoir for HIV-1 in resting memory CD4(+) T cells is the major barrier to curing HIV-1 infection. Studies of HIV-1 latency have focused on regulation of viral gene expression in cells in which latent infection is established. However, it remains unclear how infection initially becomes latent. Here we described a unique set of properties of CD4(+) T cells undergoing effector-to-memory transition including temporary upregulation of CCR5 expression and rapid downregulation of cellular gene transcription...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045322/longitudinal-associations-between-physical-activity-and-educational-outcomes
#4
Jaana T Kari, Jaakko Pehkonen, Nina Hutri-Kähönen, Olli T Raitakari, Tuija H Tammelin
PURPOSE: This longitudinal study examined the role of leisure-time physical activity in academic achievement at the end of compulsory basic education and educational attainment in adulthood. METHODS: The data were drawn from the ongoing longitudinal Cardiovascular Risk in Young Finns Study, which was combined with register-based data from Statistics Finland. The study consisted of children who were 12 yr (n = 1723, 49% boys) and 15 yr (n = 2445, 48% boys) of age at the time when physical activity was measured...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#5
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29043478/the-compensatory-enlargement-of-the-remaining-thyroid-lobe-following-hemithyroidectomy-is-small-and-without-impact-on-symptom-relief
#6
Frederik Schultz Pustelnik, Casper Gronbek, Helle Døssing, Nina Nguyen, Steen Joop Bonnema, Laszlo Hegedüs, Christian Godballe, Jesper Roed Sorensen
According to previous studies, hemithyroidectomy results in growth of the remaining thyroid lobe by up to 30% in first 12 months after surgery. However, this estimate is based on imprecise methods, high inter- and intra-observer variability, and lack of blinding of the measurements. Furthermore, it is unknown whether enlargement of the remaining hemi-thyroid interferes with the improvement in symptoms after surgery for goiter. We aimed to assess the impact of postoperative thyroid growth on goiter symptom relief following hemithyroidectomy in patients with benign nodular goiter...
October 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29042516/across-the-tree-of-life-radiation-resistance-is-governed-by-antioxidant-mn-2-gauged-by-paramagnetic-resonance
#7
Ajay Sharma, Elena K Gaidamakova, Olga Grichenko, Vera Y Matrosova, Veronika Hoeke, Polina Klimenkova, Isabel H Conze, Robert P Volpe, Rok Tkavc, Cene Gostinčar, Nina Gunde-Cimerman, Jocelyne DiRuggiero, Igor Shuryak, Andrew Ozarowski, Brian M Hoffman, Michael J Daly
Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi and human cells...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29042061/analysis-of-selected-aspects-of-inflammasome-function-in-the-monocytes-from-neonates-born-extremely-and-very-prematurely
#8
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Nina Mól, Ola Czyz, Maciej Siedlar, Przemko Kwinta
BACKGROUND: Inflammasomes regulate activation of caspase-1, which cleaves and activates interleukin (IL)-1β and IL-18, the cytokines that trigger pro-inflammatory and antimicrobial responses. There is very little known about inflammasome function in the subsets of monocytes (MO) isolated from preterm neonates born extremely and very prematurely. METHODS: A group of 76 very low birth weight patients without early-onset sepsis was divided into extremely preterm (<28 gestational week) or very preterm (28-32 gestational week) neonates...
October 5, 2017: Immunobiology
https://www.readbyqxmd.com/read/29040798/assessment-of-cognition-and-personality-as-potential-endophenotypes-in-the-western-australian-family-study-of-schizophrenia
#9
Nina S McCarthy, Johanna C Badcock, Melanie L Clark, Emma E M Knowles, Gemma Cadby, Phillip E Melton, Vera A Morgan, John Blangero, Eric K Moses, David C Glahn, Assen Jablensky
Phenotypic heterogeneity is a major barrier to understanding the genetic architecture underlying schizophrenia. Incorporating endophenotypes is one way to reduce heterogeneity and facilitate more powerful genetic analysis. Candidate endophenotypes require systematic assessment against endophenotype criteria, and a ranking of their potential utility for genetic analysis. In this study we assess 20 cognitive and personality measures in a sample of 127 families with at least 2 cases of schizophrenia per family (n = 535) plus a set of 30 control families (n = 121) against 4 endophenotype criteria: (a) be associated with the illness but not be a part of its diagnosis, (b) be heritable, (c) co-segregate with the illness in families, and (d) be found in unaffected relatives at a higher rate than in the general population...
October 12, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29040773/treatment-outcomes-of-a-randomized-trial-of-unruptured-brain-arteriovenous-malformation-eligible-unruptured-brain-arteriovenous-malformation-patients
#10
Min Lang, Nina Z Moore, Peter A Rasmussen, Mark D Bain
BACKGROUND: The guideline for treating unruptured brain arteriovenous malformations (ubAVMs) remains controversial. A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) reported lower risk of stroke or death with conservative management compared to interventional treatment. There were numerous limitations to the study, including short follow-up period and disproportionate number of patients treated with surgery and embolization. OBJECTIVE: To evaluate whether treatment of ARUBA-eligible patients have acceptable outcomes at our institution...
October 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29040631/longevity-fertility-and-fecundity-of-adult-blow-flies-diptera-calliphoridae-held-at-varying-densities-implications-for-use-in-bioconversion-of-waste
#11
Nina Jennifer Parry, Elsje Pieterse, Christopher William Weldon
Large numbers of flies are needed to produce the quantity of larvae required for insect bioconversion of waste. However, this 'mass-rearing' may negatively affect adult survival and reproductive output. This study assessed the suitability for mass-rearing of four blow fly species, Chrysomya chloropyga, Chrysomya chloropyga (Wiedemann), Chrysomya megacephala (F.), Chrysomya putoria (Wiedemann) and Lucilia sericata (Meigen). Flies were kept at densities of 20, 50, 100, 250, 500, and 1,000 flies per 30 × 30 × 30 cm cage with an even sex ratio...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040303/continuing-professional-development-for-medical-nursing-and-midwifery-cadres-in-malawi-tanzania-and-south-africa-a-qualitative-evaluation
#12
Caryl Feldacker, Jillian Pintye, Sheena Jacob, Michael H Chung, Lyn Middleton, Jill Iliffe, H Nina Kim
BACKGROUND: As innovations in the prevention and treatment of HIV and TB advance, continuing professional development (CPD) of health care workers (HCWs) remains a high priority, particularly in sub-Saharan Africa where dual TB/HIV epidemics are compounded by severe HCW shortages. There is further need to examine CPD programs to identify challenges and effective solutions to strengthen HIV/TB-related CPD. METHODS: Qualitative evaluations in Malawi, Tanzania and South Africa (RSA) were conducted using key informant interviews (KIIs) and focus group discussions (FGDs) in each country to identify barriers and enablers of effective HIV/TB-related CPD...
2017: PloS One
https://www.readbyqxmd.com/read/29040231/continuous-infraclavicular-brachial-block-versus-single-shot-nerve-block-for-distal-radius-surgery-a-prospective-randomized-control-trial
#13
Abhishek Ganta, David Ding, Nina Fisher, Jessica Lavery, Sudheer Jain, Nirmal Tejwani
OBJECTIVES: To compare the efficacy of an infraclaviclar single shot nerve block to a continuous infusion through an On Q infusion pump for rebound pain (between 12 to 24 hours post-operatively) and post operative narcotic analgesia requirements in distal radius fractures. DESIGN: Prospective Randomized Control Trial SETTINGS:: Performed at two hospitals affiliated with a large urban academic medical center PATIENTS:: Fifty patients undergoing operative fixation of distal radius fractures (OTA/AO type 23B/C) INTERVENTION:: Patients were randomized to receive either an infraclavicular block as a single shot (SSB group) or a continuous infusion through an On Q pump (On Q group) MAIN OUTCOME MEASURES:: Visual analog scale (0-10) pain levels and amount of pain medication taken RESULTS:: At all time points after discharge, mean post-operative pain scores were lower in the On Q group vs the SSB group but did not reach statistical significance...
September 1, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29040191/incidence-patterns-and-survival-of-gynecological-sarcoma-in-germany-analysis-of-population-based-cancer-registry-data-on-1066-women
#14
Klaus Pietzner, Nina Buttmann-Schweiger, Jalid Sehouli, Klaus Kraywinkel
OBJECTIVE: Sarcomas of the female genital tract are rare tumors. They are described to be associated with a poor prognosis when compared with gynecogical carcinoma. The aim of this study was to report incidence patterns and survival rates for gynecological sarcoma (GS) in Germany. METHODS/MATERIALS: Clinical data and survival rates for patients with GS diagnosed in Germany between 2009 and 2013 were extracted from the German national center for population-based cancer registry data...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29040045/being-a-grateful-leader
#15
Nina Fekaris
No abstract text is available yet for this article.
November 2017: NASN School Nurse
https://www.readbyqxmd.com/read/29039652/insights-into-co-translational-membrane-protein-insertion-by-combined-lilbid-mass-spectrometry-and-nmr-spectroscopy
#16
Oliver Peetz, Erik Henrich, Aisha Laguerre, Frank Lőhr, Christopher Hein, Volker Dötsch, Frank Bernhard, Nina Morgner
Co-translational insertion of membrane proteins into defined nanoparticle membranes has been developed as an efficient process to produce highly soluble samples in native-like environments and to study lipid dependent effects on protein structure and function. Numerous examples of structural and functional characterization of transporters, ion channels or G-protein coupled receptors in co-translationally formed nanodisc complexes demonstrate the versatility of this approach, although the basic underlying mechanisms of membrane insertion are mainly unknown...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29039532/puerarin-attenuates-the-daunorubicin-induced-apoptosis-of-h9c2-cells-by-activating-the-pi3k-akt-signaling-pathway-via-the-inhibition-of-ca2-influx
#17
Weihua Li, Min Lu, Yanhong Zhang, Danqin Xia, Zebin Chen, Linhua Wang, Nina Yin, Zhigang Wang
Puerarin extracted from Radix Puerariae is well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. In this study, we aimed to investigate the effects of puerarin on the daunorubicin (DNR)-induced apoptosis of H9c2 cells and to elucidate the potential mechanisms involved. MTT assay and flow cytometry were performed to evaluate cell cytotoxicity and apoptosis, respectively. Western blot analysis was used to assess changes in the expression levels of proteins, including caspase-3, Akt and phosphorylated Akt (p-Akt)...
October 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038778/ophthalmological-abnormalities-in-wild-european-hedgehogs-erinaceus-europaeus-a-survey-of-300-animals
#18
David Williams, Nina Adeyeye, Erni Visser
In this study we aimed to examine wild European hedgehogs (Erinaceus europaeus) in rescue centres and to determine ocular abnormalities in this animal population. Three hundred animals varying in age from 2 months to 5 years were examined, 147 being male and 153 female. All animals were evaluated with direct and indirect ophthalmoscopy and slit lamp biomicroscopy in animals where lesions were detected. Tonometry using the Tonovet rebound tonometer was undertaken in selected animals as was assessment of tear production using the Schirmer I tear test...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29038561/vitamin-d-and-cognitive-function-a-mendelian-randomisation-study
#19
Jane Maddock, Ang Zhou, Alana Cavadino, Elżbieta Kuźma, Yanchun Bao, Melissa C Smart, Kai-Uwe Saum, Ben Schöttker, Jorgen Engmann, Marie Kjærgaard, Ville Karhunen, Yiqiang Zhan, Terho Lehtimäki, Suvi P Rovio, Liisa Byberg, Jari Lahti, Pedro Marques-Vidal, Abhijit Sen, Laura Perna, Henrik Schirmer, Archana Singh-Manoux, Juha Auvinen, Nina Hutri-Kähönen, Mika Kähönen, Lena Kilander, Katri Räikkönen, Håkan Melhus, Erik Ingelsson, Idris Guessous, Katja E Petrovic, Helena Schmidt, Reinhold Schmidt, Peter Vollenweider, Lars Lind, Johan G Eriksson, Karl Michaëlsson, Olli T Raitakari, Sara Hägg, Nancy L Pedersen, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Juha Veijola, Mika Kivimaki, Rolf Jorde, Hermann Brenner, Meena Kumari, Chris Power, David J Llewellyn, Elina Hyppönen
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038314/physical-activity-reduces-risk-of-premature-mortality-in-patients-with-type-1-diabetes-with-and-without-kidney-disease
#20
Heidi Tikkanen-Dolenc, Johan Wadén, Carol Forsblom, Valma Harjutsalo, Lena M Thorn, Markku Saraheimo, Nina Elonen, Heikki O Tikkanen, Per-Henrik Groop
OBJECTIVE: The aims of the study were to assess how baseline leisure-time physical activity (LTPA) and its exercise components intensity, duration, and frequency are associated with all-cause and cardiovascular mortality in patients with type 1 diabetes 1) overall, 2) stratified by presence or absence of chronic kidney disease (CKD), and 3) stratified by sex. RESEARCH DESIGN AND METHODS: The study design was prospective and observational and included 2,639 patients with type 1 diabetes from the ongoing nationwide multicenter Finnish Diabetic Nephropathy (FinnDiane) Study...
October 16, 2017: Diabetes Care
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