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https://www.readbyqxmd.com/read/29132930/a-novel-algorithm-increases-the-delivery-of-effective-cardiac-resynchronization-therapy-during-atrial-fibrillation-the-crtee-randomized-cross-over-trial
#1
Christopher J Plummer, Christopher M Frank, Zsolt Bári, Yahya S Al Hebaishi, Ruth Nicholson Klepfer, Robert W Stadler, Subham Ghosh, Shufeng Liu, Suneet Mittal
BACKGROUND: Cardiac resynchronization therapy (CRT) requires a high % of ventricular pacing (%Vp) to maximize its clinical benefits. Atrial fibrillation (AF) has been shown to reduce %Vp in CRT due to competition with irregular intrinsic atrio-ventricular (AV) conduction. We report the results of a prospective randomized cross-over trial evaluating the amount of effective CRT delivered during AF with a novel algorithm (eCRTAF). OBJECTIVE: To determine whether eCRTAF increases the amount of effective CRT delivered during AF when compared to a currently available rate regularization algorithm...
November 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29110166/effect-of-battery-longevity-on-costs-and-health-outcomes-associated-with-cardiac-implantable-electronic-devices-a-markov-model-based-monte-carlo-simulation
#2
Jordana K Schmier, Edmund C Lau, Jasmine D Patel, Juergen A Klenk, Arnold J Greenspon
INTRODUCTION: The effects of device and patient characteristics on health and economic outcomes in patients with cardiac implantable electronic devices (CIEDs) are unclear. Modeling can estimate costs and outcomes for patients with CIEDs under a variety of scenarios, varying battery longevity, comorbidities, and care settings. The objective of this analysis was to compare changes in patient outcomes and payer costs attributable to increases in battery life of implantable cardiac defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-D)...
November 6, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29102348/coronary-venous-dissection-from-left-ventricular-lead-placement-during-cardiac-resynchronization-therapy-with-defibrillator-implantation-and-associated-in-hospital-adverse-events-from-the-ncdr-icd-registry
#3
Jonathan C Hsu, Paul D Varosy, Haikun Bao, Thomas A Dewland, Jeptha P Curtis, Gregory M Marcus
Coronary venous dissection is a known complication of left ventricular lead placement during implantation of a cardiac resynchronization with defibrillator (CRT-D) system. A large-scale evaluation of the prevalence of coronary venous dissection and associated in-hospital clinical outcomes has not been performed. We sought to identify predictors of coronary venous dissection and evaluate subsequent in-hospital adverse events in those with the complication. We studied 140,991 first-time CRT-D recipients in the implantable cardioverter-defibrillator (ICD) Registry implanted between 2006 and 2011...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29052236/heart-failure-severity-inappropriate-icd-therapy-and-novel-icd-programming-a-madit-rit-sub-study
#4
Usama A Daimee, Katherine Vermilye, Spencer Rosero, Claudio D Schuger, James P Daubert, Wojciech Zareba, Scott McNitt, Bronislava Polonsky, Arthur J Moss, Valentina Kutyifa
BACKGROUND: The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter-defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT-RIT. METHODS: MADIT-RIT randomized 1500 patients to three ICD programming arms: conventional (Arm A), high-rate cut-off (Arm B: ≥200 bpm), and delayed therapy (Arm C: 60-second delay for ≥170 bpm)...
October 20, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29050686/gender-differences-in-cardiac-resynchronization-therapy-device-choice-and-outcome-in-patients-%C3%A2-75-years-of-age-with-heart-failure
#5
Yanting Wang, Michael S Sharbaugh, Mohammad Bilal Munir, Evan C Adelstein, Norman C Wang, Andrew D Althouse, Samir Saba
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure and can be delivered through a CRT pacemaker (CRT-P) or a CRT defibrillator (CRT-D). CRT-P devices are smaller and less expensive, have better battery longevity, and have been subject to fewer recalls and advisories but cannot deliver high-energy shocks to terminate potentially lethal ventricular arrhythmias. As published guidelines do not distinguish between CRT-P and CRT-D indications, we examined the practice of prescribing these devices in older women and men with heart failure...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29048460/cardiovascular-magnetic-resonance-imaging-in-patients-with-cardiac-implantable-electronic-devices-a-device-dependent-imaging-strategy-for-improved-image-quality
#6
Sebastian Hilbert, Cosima Jahnke, Susanne Loebe, Sabrina Oebel, Alexander Weber, Ricardo Spampinato, Sergio Richter, Michael Doering, Andreas Bollmann, Philipp Sommer, Gerhard Hindricks, Ingo Paetsch
Aims: To prospectively determine evaluability of routine cardiovascular magnetic resonance (CMR) diagnostic modules in a referral population of implanted rhythm device all-comers, and to establish a device-dependent CMR imaging strategy to achieve optimal image quality. Methods and results: One hundred and twenty-eight patients with cardiac implantable electronic devices [insertable cardiac monitoring system, n = 14; implantable loop-recorder, n = 21; pacemaker, n = 31; implantable cardioverter-defibrillator (ICD), n = 50; and cardiac resynchronization therapy defibrillator (CRT-D), n = 12] underwent clinically indicated CMR at 1...
October 18, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29045311/cardiac-resynchronization-therapy-outcomes-in-patients-with-chronic-heart-failure-cardiac-resynchronization-therapy-with-pacemaker-versus-cardiac-resynchronization-therapy-with-defibrillator
#7
Michael Drozd, John Gierula, Judith E Lowry, Maria F Paton, Eleanor Joy, Haqeel A Jamil, Richard M Cubbon, Mark T Kearney, David A Cairns, Klaus K Witte
AIMS: Cardiac resynchronization therapy (CRT) for chronic heart failure with left ventricular systolic dysfunction (LVSD) consistently improves survival against optimal medical therapy alone. Limited data exist comparing the outcomes between CRT with pacemaker (CRT-P) and with defibrillator (CRT-D). We aimed to investigate the long-term prognosis of patients who received CRT-P or CRT-D. METHODS AND RESULTS: Data were prospectively collected from consecutive patients with standard indications for CRT, who were implanted at a single large tertiary centre between 2008 and 2012...
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29036292/association-between-implantable-cardioverter-defibrillator-therapy-and-different-lead-positions-in-patients-with-cardiac-resynchronization-therapy
#8
Mads Brix Kronborg, Jens Brock Johansen, Jens Haarbo, Sam Riahi, Berit Thornvig Philbert, Ole Dan Jørgensen, Jens Cosedis Nielsen
Aims: To evaluate the impact of different right and left ventricular lead positions (RV-LP and LV-LP) on the risk of therapy for ventricular tachycardia/ventricular fibrillation in patients with a cardiac resynchronization therapy device (CRT-D). Methods and results: We performed a large nationwide cohort study on patients in Denmark receiving a CRT-D device from 2008 to 2012 from the Danish Pacemaker and implantable cardioverter defibrillator (ICD) registry. Lead positions were registered during the implantation and categorized as anterior/lateral/posterior and basal/mid-ventricular/apical for the LV-LP, and as apical/non-apical for the RV-LP...
September 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29030709/bleeding-risk-of-submuscular-icd-implantation-with-continued-oral-anticoagulation-versus-heparin-bridging-therapy
#9
Simon Pecha, Ayhan Ayikli, Iris Wilke, Samer Hakmi, Yalin Yildirim, Nils Gosau, Hermann Reichenspurner, Stephan Willems, Muhammet Ali Aydin
Recent studies have shown that subcutaneous or subfascial pacemaker- and ICD implantation with continued oral anticoagulation therapy is associated with lower risk for bleeding complications, when compared to heparin bridging strategies. However, ICD generators are often implanted submuscularly. We therefore compared the bleeding risk with continued phenprocoumon therapy vs. heparin bridging in patients receiving submuscular ICD implantation. Between 01/2013 and 12/2013, 104 patients with need for oral anticoagulation received submuscular ICD or CRT-D implantation in our institution...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29030235/impact-of-ventricular-tachycardia-ablation-on-healthcare-utilization
#10
Jeffrey R Winterfield, Alexander R Kent, Edward Karst, Nirav Dalal, Srijoy Mahapatra, T Jared Bunch, Matthew R Reynolds, David J Wilber
BACKGROUND: Catheter ablation of ventricular tachycardia (VT) has been shown to reduce the number of recurrent shocks in patients with implantable cardioverter defibrillators (ICDs). However, it remains unclear how VT ablation affects post-procedural medical and pharmaceutical usage. OBJECTIVES: The objective of this study was to investigate changes in healthcare resource utilization (HCRU) following VT ablation. METHODS: This large-scale, real-world, retrospective study used the MarketScan databases to identify patients in the U...
October 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29028784/manufacturer-change-and-risk-of-system-related-complications-after-implantable-cardioverter-defibrillator-replacement-physicians-survey-and-data-from-the-detect-long-term-complications-after-implantable-cardioverter-defibrillator-replacement-registry
#11
Mauro Biffi, Endrj Menardi, Maria L Narducci, Ernesto Ammendola, Loredana Messano, Fabrizio Giofrè, Claudia Baiocchi, Davide Saporito, Fabio Lissoni, Matteo Bertini, Attilio Pierantozzi, Gianluca Zingarini, Maurizio Malacrida, Matteo Ziacchi
AIMS: Some barriers seem to exist in changing implantable cardioverter defibrillator (ICD) manufacturer at the time of device replacement. We sought to understand the obstacles to changing ICD manufacturer within the cohort of patients enrolled in the Detect Long-term Complications After ICD Replacement Registry. METHODS: We analyzed 784 consecutive ICD/cardiac resynchronization therapy defibrillator (CRT-D) device replacements within a 1.5-year time-frame in 36 Italian centers to evaluate potential factors associated with changing manufacturers and system-related complications...
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29016821/super-response-to-cardiac-resynchronization-therapy-reduces-appropriate-implantable-cardioverter-defibrillator-therapy
#12
Ammar M Killu, Anna Mazo, Avishay Grupper, Malini Madhavan, Tracy Webster, Kelly L Brooke, David O Hodge, Samuel J Asirvatham, Paul A Friedman, Michael Glikson, Yong-Mei Cha
Aims: To determine the frequency of implantable cardioverter defibrillator (ICD) therapy following cardiac resynchronization therapy (CRT-D) implantation in super and non-super responders and whether greater improvement in left ventricular (LV) function after CRT is associated with a reduced burden in ICD therapy. Methods and results: This is a two-centre, retrospective study between January 2002 and September 2011. Patients were classified as non-super responders and super-responders based on the post-CRT ejection fraction (EF) of < 50% and ≥50%, respectively...
August 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016784/sex-differences-in-outcomes-of-primary-prevention-implantable-cardioverter-defibrillator-therapy-combined-registry-data-from-eleven-european-countries
#13
Christian Sticherling, Barbora Arendacka, Jesper Hastrup Svendsen, Sofieke Wijers, Tim Friede, Jochem Stockinger, Michael Dommasch, Bela Merkely, Rik Willems, Andrzej Lubinski, Michael Scharfe, Frieder Braunschweig, Martin Svetlosak, Christine S Zürn, Heikki Huikuri, Panagiota Flevari, Caspar Lund-Andersen, Beat A Schaer, Anton E Tuinenburg, Leonard Bergau, Georg Schmidt, Gabor Szeplaki, Bert Vanderberk, Emilia Kowalczyk, Christian Eick, Juhani Juntilla, David Conen, Markus Zabel
Aims: Therapy with an implantable cardioverter defibrillator (ICD) is established for the prevention of sudden cardiac death (SCD) in high risk patients. We aimed to determine the effectiveness of primary prevention ICD therapy by analysing registry data from 14 centres in 11 European countries compiled between 2002 and 2014, with emphasis on outcomes in women who have been underrepresented in all trials. Methods and results: Retrospective data of 14 local registries of primary prevention ICD implantations between 2002 and 2014 were compiled in a central database...
June 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016777/long-term-impact-of-intrathoracic-impedance-findings-on-survival-and-heart-failure-hospitalizations-after-cardiac-resynchronization-therapy-in-icd-registry-patients
#14
Jason R Brown, Alvaro Alonso, Eduardo N Warman, Kenneth C Bilchick
Aims: To determine adjusted associations among OptiVol® threshold crossings, long-term survival, and hospitalizations among heart failure (HF) patients with Medicare coverage in the United States. Methods and results: A cohort with OptiVol®-enabled cardiac resynchronization therapy defibrillators (CRT-D) devices from the Implantable Cardioverter Defibrillator Registry was linked to both Medicare claims/summary data and Medtronic's CareLink® Network data. An extended multivariable Cox model was used to analyse associations among OptiVol® threshold crossings (treated as time-dependent covariates), mortality, and HF-related hospitalizations (HFH)...
August 25, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28987045/acalculous-cholecystitis-in-a-female-with-cardiac-device-related-infective-endocarditis
#15
Waldemar Elikowski, Przemysław Mitkowski, Małgorzata Małek-Elikowska, Jerzy Gizło, Lidia Chmielewska-Michalak, Stanisław Łazowski
Acute acalculous cholecystitis (AAC) is a necroinflammatory disease of the gallbladder with no gallstones present. ACC is known to be a serious, even potentially lethal complication observed mainly in patients with various severe underlying conditions including trauma, burn and sepsis. Infection of cardiac implantable electronic devices may lead to cardiac device-related infective endocarditis (CDRIE). The authors describe a case of a 55-year-old female with a history of advanced heart failure and implantation/reimplantation of biventricular pacemaker/defibrillator (CRT-D) for cardiac resynchronization therapy...
September 29, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28940909/postimplantation-ventricular-ectopic-burden-and-clinical-outcomes-in-cardiac-resynchronization-therapy-defibrillator-patients-a-madit-crt-substudy
#16
Anne-Christine Ruwald, Mehmet K Aktas, Martin H Ruwald, Valentina Kutyifa, Scott McNitt, Christian Jons, Suneet Mittal, Jonathan S Steinberg, James P Daubert, Arthur J Moss, Wojciech Zareba
BACKGROUND: Frequent ventricular ectopy on preimplantation Holter has been associated with attenuated benefit from cardiac resynchronization therapy (CRT). However, it is unclear whether ectopic burden measured post-CRT implantation can be utilized to evaluate long-term prognosis. We aimed to describe the association between post-CRT implantation ectopic burden and subsequent risk of clinical outcomes. METHODS: At the 12-month follow-up visit, 24-hour Holter recordings were performed in 698 CRT-D patients from the MADIT-CRT study...
September 20, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28917559/predictors-and-outcomes-of-cardiac-resynchronization-therapy-extended-to-the-second-generator
#17
Xuping Li, Dachun Yang, Fred Kusumoto, Win-Kuang Shen, Siva Mulpuru, Shenghua Zhou, Jinjun Liang, Gang Wu, Mei Yang, Jin-Qu Liu, Paul A Friedman, Yong-Mei Cha
BACKGROUND: A proportion of patients who receive cardiac resynchronization therapy with defibrillator (CRT-D) live to receive a second generator. Controversy exists on whether an implantable cardioverter-defibrillator (ICD) should be offered to patients who have normalized or near-normalized left ventricular ejection fraction (LVEF) at the time of generator replacement (GR). OBJECTIVE: The purpose of this study was to evaluate incidence of appropriate ICD therapy after CRT-D GR...
September 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28893549/continuous-optimization-of-cardiac-resynchronization-therapy-reduces-atrial-fibrillation-in-heart-failure-patients-results-of-the-adaptive-cardiac-resynchronization-therapy-trial
#18
David Birnie, Harrison Hudnall, Bernd Lemke, Kazutaka Aonuma, Kathy Lai-Fun Lee, Maurizio Gasparini, John Gorcsan, Jeffrey Cerkvenik, David O Martin
BACKGROUND: Data from randomized trials have suggested a modest or no effect of conventional cardiac resynchronization therapy (convCRT) on the incidence of atrial fibrillation (AF). AdaptivCRT (aCRT, Medtronic, Mounds View, MN) is a recently described algorithm for synchronized left ventricular (LV) pacing and continuous optimization of cardiac resynchronization therapy (CRT). OBJECTIVE: We compared the long-term effects of aCRT with convCRT pacing on the incidence of AF...
September 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28862407/an-handbook-for-the-clinical-cardiologist-about-crt-icd-a-pratical-guide-about-how-to-survive-during-an-on-call-shift
#19
Fabiana Lucà, Emilia Biscottini, Laura Cipolletta, Marco Marini, Giorgio Caretta, Alberto Lavorgna, Fabio Vagnarelli, Stefania A DI Fusco, Vincenza Procaccini, Letizia Riva, Gabriele Vianello, Renata DE Maria, Achille Giardina, Michele M Gulizia
INTRODUCTION: Cardiac Resynchronization Therapies (CRTs) have been demonstrated to improve the clinical management and prognosis of selected patients with heart failure. EVIDENCE ACQUISITION: CRT devices include both CRT Pacemakers (CRT-P) and CRT defibrillators (CRT-D), with the latter being used to treat life-threatening ventricular arrhythmias. EVIDENCE SYNTHESIS: A significant advantage of CRTs is the ability to monitor several vital parameters which, thanks to advanced technology, may be remotely assessed...
August 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28859784/outcomes-of-cardiac-resynchronization-therapy-with-or-without-defibrillation-in-patients-with-nonischemic-cardiomyopathy
#20
MULTICENTER STUDY
Francisco Leyva, Abbasin Zegard, Edmund Acquaye, Christopher Gubran, Robin Taylor, Paul W X Foley, Fraz Umar, Kiran Patel, Jonathan Panting, Howard Marshall, Tian Qiu
BACKGROUND: Recent studies have cast doubt on the benefit of cardiac resynchronization therapy (CRT) with defibrillation (CRT-D) versus pacing (CRT-P) for patients with nonischemic cardiomyopathy (NICM). Left ventricular myocardial scar portends poor clinical outcomes. OBJECTIVES: The aim of this study was to determine whether CRT-D is superior to CRT-P in patients with NICM either with (+) or without (-) left ventricular midwall fibrosis (MWF), detected by cardiac magnetic resonance...
September 5, 2017: Journal of the American College of Cardiology
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