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https://www.readbyqxmd.com/read/28917559/predictors-and-outcomes-of-cardiac-resynchronization-therapy-extended-to-the-second-generator
#1
Xuping Li, Dachun Yang, Fred Kusumoto, Win-Guang Shen, Siva Mulpuru, Shenghua Zhou, Jinjun Liang, Gang Wu, Mei Yang, Jin-Qu Liu, Paul A Friedman, Yong-Mei Cha
BACKGROUND: A proportion of patients who receive cardiac resynchronization therapy (CRT) with defibrillator (CRT-D) live to receive a second generator. Controversy exists on whether an implantable cardioverter-defibrillator (ICD) should be offered to patients who have normalized or near normalized left ventricular ejection fraction (LVEF) at the time of generator replacement (GR). OBJECTIVE: To evaluate incidence of appropriate ICD therapy after CRT-D GR. METHODS: This series involved 1,026 consecutive patients who underwent CRT-D implant between January 2002 and December 2012...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28893549/continuous-optimization-of-cardiac-resynchronization-therapy-reduces-atrial-fibrillation-in-heart-failure-patients-results-of-the-adaptive-cardiac-resynchronization-therapy-trial
#2
David Birnie, Harrison Hudnall, Bernd Lemke, Kazutaka Aonuma, Kathy Lai-Fun Lee, Maurizio Gasparini, John Gorcsan, Jeffrey Cerkvenik, David O Martin
BACKGROUND: Data from randomized trials have suggested a modest or no effect of conventional cardiac resynchronization therapy (convCRT) on the incidence of atrial fibrillation (AF). AdaptivCRT (aCRT, Medtronic, Mounds View, MN) is a recently described algorithm for synchronized left ventricular (LV) pacing and continuous optimization of cardiac resynchronization therapy (CRT). OBJECTIVE: We compared the long-term effects of aCRT with convCRT pacing on the incidence of AF...
September 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28862407/an-handbook-for-the-clinical-cardiologist-about-crt-icd-a-pratical-guide-about-how-to-survive-during-an-on-call-shift
#3
Fabiana Lucà, Emilia Biscottini, Laura Cipolletta, Marco Marini, Giorgio Caretta, Alberto Lavorgna, Fabio Vagnarelli, Stefania A DI Fusco, Vincenza Procaccini, Letizia Riva, Gabriele Vianello, Renata DE Maria, Achille Giardina, Michele M Gulizia
INTRODUCTION: Cardiac Resynchronization Therapies (CRTs) have been demonstrated to improve the clinical management and prognosis of selected patients with heart failure. EVIDENCE ACQUISITION: CRT devices include both CRT Pacemakers (CRT-P) and CRT defibrillators (CRT-D), with the latter being used to treat life-threatening ventricular arrhythmias. EVIDENCE SYNTHESIS: A significant advantage of CRTs is the ability to monitor several vital parameters which, thanks to advanced technology, may be remotely assessed...
August 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28859784/outcomes-of-cardiac-resynchronization-therapy-with-or-without-defibrillation-in-patients-with-nonischemic-cardiomyopathy
#4
MULTICENTER STUDY
Francisco Leyva, Abbasin Zegard, Edmund Acquaye, Christopher Gubran, Robin Taylor, Paul W X Foley, Fraz Umar, Kiran Patel, Jonathan Panting, Howard Marshall, Tian Qiu
BACKGROUND: Recent studies have cast doubt on the benefit of cardiac resynchronization therapy (CRT) with defibrillation (CRT-D) versus pacing (CRT-P) for patients with nonischemic cardiomyopathy (NICM). Left ventricular myocardial scar portends poor clinical outcomes. OBJECTIVES: The aim of this study was to determine whether CRT-D is superior to CRT-P in patients with NICM either with (+) or without (-) left ventricular midwall fibrosis (MWF), detected by cardiac magnetic resonance...
September 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28846805/an-exploration-of-the-association-between-ischemic-etiology-and-the-likelihood-of-heart-failure-hospitalization-following-cardiac-resynchronization-therapy
#5
Adam C Powell, Teresa L Rogstad, Uday U Deshmukh, Stephen E Price, Jeffrey D Simmons
BACKGROUND: Myocardial scarring resulting from cardiomyopathy with ischemic etiology may interfere with effective lead placement during implantation of multi-lead cardioverter-defibrillators for cardiac resynchronization therapy (CRT-D). Extensive scarring is known to be associated with poorer physiological and survival outcomes in patients who undergo CRT-D. HYPOTHESIS: Ischemic CRT-D recipients respond as well as nonischemic recipients, using hospital admission for heart failure (HF) as a measure of response...
August 28, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28846144/impact-of-icd-lead-on-the-system-durability-predictors-of-long-term-survival-following-icd-system-extraction
#6
Wojciech Jacheć, Andrzej Tomasik, Anna Polewczyk, Andrzej Kutarski
BACKGROUND: ICD and CRT-D systems are considered as having higher risk of complication and shorter durability but reasons of this multifactorial phenomenon remain unclear. We aimed to analyze this problem in population of patients with ICD leads referred for lead extraction (TLE). METHODS: We have compared TLE indications, procedural results and defined the long-term outcomes of TLE in patients with ICD / CRTD devices (n = 482, ICD(+)) with lead extractions in patients with standard pacemakers (n = 1402, ICD(-))...
August 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28780194/scar-characterization-to-predict-life-threatening-arrhythmic-events-and%C3%A2-sudden-cardiac-death-in-patients-with-cardiac-resynchronization-therapy-the-gaudi-crt-study
#7
Juan Acosta, Juan Fernández-Armenta, Roger Borràs, Ignasi Anguera, Felipe Bisbal, Julio Martí-Almor, Jose M Tolosana, Diego Penela, David Andreu, David Soto-Iglesias, Reinder Evertz, María Matiello, Concepción Alonso, Roger Villuendas, Teresa M de Caralt, Rosario J Perea, Jose T Ortiz, Xavier Bosch, Luis Serra, Xavier Planes, Andreas Greiser, Okan Ekinci, Luis Lasalvia, Lluis Mont, Antonio Berruezo
OBJECTIVES: The aim of this study was to analyze whether scar characterization could improve the risk stratification for life-threatening ventricular arrhythmias and sudden cardiac death (SCD). BACKGROUND: Among patients with a cardiac resynchronization therapy (CRT) indication, appropriate defibrillator (CRT-D) therapy rates are low. METHODS: Primary prevention patients with a class I indication for CRT were prospectively enrolled and assigned to CRT-D or CRT pacemaker according to physician's criteria...
July 28, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28724879/infectious-complications-in-patients-with-cardiac-implantable-electronic-devices-risk-factors-prevention-and-prognosis
#8
Anna Polewczyk, Wojciech Jacheć, Aneta Maria Polewczyk, Andrzej Tomasik, Marianna Janion, Andrzej Kutarski
INTRODUCTION    Cardiac device infections (CDI) are still a significant problem. The knowledge of risk factors for CDI is crucial both for preventing infections and reducing mortality. OBJECTIVES    The assesment of the risk factors and long term survival of patients with CDI. PATIENTS AND METHODS    The clinical data of 1837 patients (40.9% CDI) undergoing transvenous leads extraction (TLE) at a single institution from 2006 to 2015 was analyzed. We compared the clinical and procedure-related factors for all types of CDI: isolated pocket infection (IPI), isolated lead-related infective endocarditis (ILRIE) and PI+LRIE...
July 19, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28716973/incremental-benefit-of-cardiac-resynchronisation-therapy-with-versus-without-a-defibrillator
#9
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Dieter Nuyens, Hugo Van Herendael, Maximo Rivero-Ayerza, Wilson H Tang, Wilfried Mullens
OBJECTIVE: To determine the incremental value of implantable cardioverter defibrillators (ICD) in contemporary optimally treated patients with heart failure (HF) undergoing cardiac resynchronisation therapy (CRT). METHODS: Consecutive patients with HF undergoing CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) implantation in a single tertiary care centre between October 2008 and August 2015 were retrospectively evaluated. For patients with a primary prevention indication of the CRT-D, no benefit of the ICD was defined as absence of appropriate therapy (device analysis) or lethal ventricular tachyarrhythmias (mode of death analysis) during follow-up...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28708197/risk-stratification-personalised-model-for-prediction-of-life-threatening-ventricular-tachyarrhythmias-in-patients-with-chronic-heart-failure
#10
Alexander Vladimirovich Frolov, Tatjana Gennadjevna Vaikhanskaya, Olga Petrovna Melnikova, Anatoly Pavlovich Vorobiev, Ludmila Michajlovna Guel
BACKGROUND: The development of prognostic factors of life-threatening ventricular tachyarrhythmias (VTA) and sudden cardiac death (SCD) continues to maintain its priority and relevance in cardiology. The development of a method of personalised prognosis based on multifactorial analysis of the risk factors associated with life-threatening heart rhythm disturbances is considered a key research and clinical task. AIM: To design a prognostic and mathematical model to define personalised risk for life-threatening VTA in patients with chronic heart failure (CHF)...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28688704/long-term-survival-of-patients-with-left-bundle-branch-block-who-are-hypo-responders-to-cardiac-resynchronization-therapy
#11
RANDOMIZED CONTROLLED TRIAL
Himabindu Vidula, Valentina Kutyifa, Scott McNitt, Ilan Goldenberg, Scott D Solomon, Arthur J Moss, Wojciech Zareba
Guidelines support cardiac resynchronization therapy with a defibrillator (CRT-D) in mild heart failure (HF) patients with left bundle branch block (LBBB). However, not all patients demonstrate echocardiographic or clinical response to CRT-D. We aimed to evaluate the long-term outcomes of echocardiographic hypo-responders and clinical hypo-responders to CRT-D with LBBB in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy. Five-hundred thirty-four patients with LBBB in the CRT-D arm were followed for 5...
September 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28679168/risk-stratification-of-cardiovascular-and-heart-failure-hospitalizations-using-integrated-device-diagnostics-in-patients-with-a-cardiac-resynchronization-therapy-defibrillator
#12
Haran Burri, Antoine da Costa, Aurelio Quesada, Renato Pietro Ricci, Stefano Favale, Nicolas Clementy, Gabriele Boscolo, Federico Segura Villalobos, Lorenza Mangoni di S Stefano, Vinod Sharma, Giuseppe Boriani
Aims: Cardiac resynchronization therapy defibrillators (CRT-D) are able to monitor various parameters that may be combined by an automatic algorithm to provide a heart failure risk status (HFRS). We sought to validate the HFRS for stratifying patient risk, evaluate its association with heart failure (HF) symptoms, and investigate its utility for triage of automatic alerts. Methods and results: Data from 722 patients included in the MORE-CARE trial were analysed in a post hoc analysis...
June 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28666319/cause-of-death-analysis-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-a-systematic-review-and-proportional-meta-analysis
#13
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, David Begley, Andrew Grace, Kumar Narayanan, Anthony Tang, Eloi Marijon, Sharad Agarwal
Aims: The additional benefit of a defibrillator in cardiac resynchronization therapy (CRT) patients is a matter of debate. Cause-of-death analysis in a CRT population has been recently proposed as a useful approach to gain insight into this problem. We performed a systematic review and meta-analysis looking at cause of death in studies involving CRT subjects with (CRT-D) or without (CRT-P) a defibrillator. Methods and results: Literature search performed from inception to 31 March 2016 for relevant studies...
June 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28653315/effectiveness-of-medtronic-carelink-express-system-in-identifying-patients-with-high-energy-electrotherapy-devices-requiring-clinically-significant-intervention
#14
Marcin Grabowski, Sabina Sadecka, Andrzej Cacko, Marcin Michalak, Leszek Blicharz, Paweł Balsam, Grzegorz Opolski
BACKGROUND: The number of patients with implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy and defibrillator (CRT-D) is growing. This results in high workloads for centers performing standard controls (SC) of these systems. Medtronic CareLink Express (MCLE) is a solution enabling remote controls (RC) of implantable devices. In cases of detecting arrhythmias or device malfunctioning, it automatically generates alarms transmitted to the controlling physician...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28653309/refined-heart-failure-detection-algorithm-for-improved-clinical-reliability-of-optivol-alerts-in-crt-d-recipients
#15
Mate Vamos, Noemi Nyolczas, Zsolt Bari, Peter Bogyi, Balazs Muk, Barna Szabo, Bettina Ancsin, Robert G Kiss, Gabor Z Duray
BACKGROUND: The reliability of intrathoracic impedance monitoring for prediction of heart failure (HF) by implantable cardiac devices is controversial. Despite using additional device-based parameters described in the PARTNERS HF study, such as new onset of arrhythmias, abnormal autonomics, low biventricular pacing rate or patient activity level, the predictive power of device diagnostic algorithm is still in doubt. The objective of this study was to compare the device diagnostic algorithm described in the PARTNERS HF study to a newly developed algorithm applying refined diagnostic criteria...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28626201/survival-and-heart-failure-hospitalization-in-patients-with-cardiac-resynchronization-therapy-with-or-without-a-defibrillator-for-primary-prevention-in-japan%C3%A3-analysis-of-the-japan-cardiac-device-treatment-registry-database
#16
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
BACKGROUND: Randomized control trials comparing the effectiveness of cardiac resynchronization therapy devices, with (CRT-D) or without (CRT-P) a defibrillator, are scarce in heart failure patients with no prior sustained ventricular tachyarrhythmias.Methods and Results:The Japan Cardiac Device Treatment Registry (JCDTR) has data for 2714 CRT-D and 555 CRT-P recipients for primary prevention with an implantation date between January 2011 and August 2015. Of these patients, follow-up data were available for 717...
June 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28599667/multipolar-pacing-by-cardiac-resynchronization-therapy-with-a-defibrillators-treatment-in-type-2-diabetes-mellitus-failing-heart-patients-impact-on-responders-rate-and-clinical-outcomes
#17
Celestino Sardu, Michelangela Barbieri, Matteo Santamaria, Valerio Giordano, Cosimo Sacra, Pasquale Paolisso, Alessandro Spirito, Raffaele Marfella, Giuseppe Paolisso, Maria Rosaria Rizzo
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multi factorial disease, affecting clinical outcomes in failing heart patients treated by cardiac resynchronization therapy with a defibrillator (CRT-d). METHODS: One hundred and ninety-five T2DM patients received a CRT-d treatment. Randomly the study population received a CRT-d via multipolar left ventricle (LV) lead pacing (n 99, multipolar group), vs a CRT-d via bipolar LV pacing (n 96, bipolar group). These patients were followed by clinical, and instrumental assessment, and telemetric device control at follow up...
June 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28597793/the-effectiveness-of-crt-on-improvement-of-survival-of-heart-failure-patients-in-real-life-clinical-settings
#18
Marek Hudak, Michal Kerekanic, Silvia Misikova, Erika Komanova, Alexander Boho, Branislav Stancak
Objectives Prolongation of QRS (≥ 120 ms) in patients with heart failure (HF) is associated with higher all-cause mortality than in those with narrow QRS. The aim of our study was to compare the survival of patients with HF and wide QRS after cardiac resynchronization therapy (CRT) with survival of HF patients with narrow QRS and to assess factors predictive of non-response to CRT. Methods We enrolled 680 patients with advanced HF and optimal pharmacologic therapy. All patients were assigned according to duration of QRS complex and implanted device...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28595339/cardiac-resynchronization-therapy-and-electrical-storm-results-of-the-observational-registry-on-long-term-outcome-of-icd-patients-observo-icd
#19
Federico Guerra, Pietro Palmisano, Gabriele Dell'Era, Matteo Ziacchi, Ernesto Ammendola, Giulia Pongetti, Paolo Bonelli, Francesca Patani, Chiara Devecchi, Michele Accogli, Eraldo Occhetta, Gerardo Nigro, Mauro Biffi, Giuseppe Boriani, Alessandro Capucci
Aims: Electrical storm (ES) is a condition defined as three or more episodes of ventricular fibrillation (VF) or ventricular tachycardia (VT) within 24 h, and usually coexist with advanced heart failure in patients with structural heart disease. The aim of the present study is to test whether cardiac resynchronization therapy (CRT) can be associated with a lower incidence of ES. Methods and results: The OBSERVO-ICD (NCT02735811) is a multicentre, retrospective registry, enrolling all consecutive patients undergoing ICD or CRT-D implantation from 2010 to 2012 in five Italian high-volume arrhythmia centres...
June 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28553663/does-the-implantable-cardioverter-defibrillator-benefit-vary-with-the-estimated-proportional-risk-of-sudden-death-in-heart-failure-patients
#20
Wayne C Levy, Yanhong Li, Shelby D Reed, Michael R Zile, Ramin Shadman, Todd Dardas, David J Whellan, Kevin A Schulman, Stephen J Ellis, Matthew Neilson, Christopher M O'Connor
BACKGROUND: Prediction of which heart failure patients are most likely to die of sudden death vs. non-sudden death is an important factor in determining who will benefit the most from an ICD. OBJECTIVE: We developed the Seattle Proportional Risk Model (SPRM) to estimate the proportion of total mortality due to sudden death. We prospectively validated the model in HF-ACTION and tested whether the ICD benefit varied with the SPRM. METHODS: Among 2331 patients enrolled, 1947 patients were retained for analysis over a median follow-up of 2...
March 2017: JACC. Clinical Electrophysiology
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