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https://www.readbyqxmd.com/read/28416736/nomo-1-gene-is-deleted-in-early-onset-colorectal-cancer
#1
José Perea, Juan Luis García, Jessica Pérez, Daniel Rueda, María Arriba, Yolanda Rodríguez, Miguel Urioste, Rogelio González-Sarmiento
To characterize clinical features of a recurrent alteration in 16p13.12-p13.11 in Colorectal Cancer (CRC), mainly in Early-onset subgroup (EOCRC), and to assess the status of NOMO1, a gene located in that region, we analyzed differential clinicopathological, familial and molecular features of CRC subsets with and without alterations in the 16p13.12-p13.11, in global and EOCRC groups. We confirmed the region by fluorescence in-situ hybridization, and Quantitative Real-Time PCR analyzed the status of NOMO1 in different age-of-onset and Microsatellite Instability (MSI)-status CRC subsets...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28339363/proangiogenic-gene-polymorphisms-are-associated-with-susceptibility-to-paget-s-disease-of-bone-and-with-its-clinical-features
#2
Ismael Calero-Paniagua, Ricardo Usategui-Martín, Luís Corral-Gudino, Judit García-Aparicio, Javier Del Pino-Montes, Rogelio González-Sarmiento
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March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28256271/impact-of-locally-advanced-or-metastatic-prostate-cancer-on-the-quality-of-life
#3
I López-Calderero, L López-Fando, E Ríos-González, P Maisonobe, E Hernández-Yuste, M Sarmiento-Jordán
OBJECTIVE: The aim of this study was to assess the health-related quality of life of patients with prostate cancer in advanced phases to obtain additional information on the patients' health. The growing interest in understanding the patient's perspective and the scarcity of prospective studies of this population motivated this research study. MATERIAL AND METHODS: We present an observational study performed on 131 urology consultations, with a sample of 601 patients with locally advanced or metastatic prostate cancer, assessed during 2 visits: baseline and at 12 months...
February 27, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#4
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28185666/-effects-of-a-recreational-general-physical-activity-program-with-short-term-and-moderate-intensity-of-blood-pressure-and-other-cardiovascular-risk-factors-in-hypertensive-patients-over-50-years-old
#5
Ana Torija Archilla, Javier Pérez González, Álvaro Sarmiento Ramírez, Enrique Fernández Sánchez, Josué Rubén González Ruiz, Rafael Guisado Barrilao
OBJECTIVES: To evaluate the effects of a recreational general physical activity program with moderate intensity and short duration on blood pressure and other cardiovascular risk factors (BMI, cholesterol, Rest Heart Rate, HDL, LDL, Triglycerides) in hypertensive patients older than 50years. DESIGN: Non-randomised pre-post design, quasi-experimental study. LOCATION: Íllora, Granada, Spain. PARTICIPANTS: A total of 60 subjects aged 50-75years taking part in the Health Hypertensive Program in the Medical Centre were selected...
February 6, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28161847/study-of-gastrointestinal-parasites-in-water-buffalo-bubalus-bubalis-reared-under-mexican-humid-tropical-conditions
#6
Nadia Florencia Ojeda-Robertos, Oswaldo Margarito Torres-Chablé, Jorge Alonso Peralta-Torres, Carlos Luna-Palomera, Aguilar Aguilar-Cabrales, Alfonso Juventino Chay-Canul, Roberto González-Garduño, Carlos Machain-Williams, Ramón Cámara-Sarmiento
The objective was to determine the frequency of gastrointestinal parasites (GP) genera affecting water buffalo (Bubalus bubalis) reared under humid tropical conditions of Mexico. Three hundred eighty-three Munrah breed water buffalo were included, 251 adult females and 132 calves. Feces were directly collected form the rectum of the animals and processed by the McMaster technique. Coprocultures were made to identify the genera of the nematodes. The frequency of GP in B. bubalis was 42%, independently of their age, 60% of calves resulted parasitized...
March 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28157227/association-of-vav2-and-vav3-polymorphisms-with-cardiovascular-risk-factors
#7
Nuria Perretta-Tejedor, Javier Fernández-Mateos, Luis García-Ortiz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, Cristina Agudo-Conde, Emiliano Rodriguez-Sánchez, Ana I Morales, Francisco J López-Hernández, José M López-Novoa, Rogelio González-Sarmiento, Carlos Martínez-Salgado
Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28125715/correction-study-of-association-between-pre-senile-cataracts-and-the-polymorphisms-rs2228000-in-xpc-and-rs1042522-in-p53-in-spanish-population
#8
Gloria López Valverde, Elena Garcia Martin, José M Larrosa Povés, Vicente Polo Llorens, Javier Fernández Mateos, Luis E Pablo Júlvez, Rogelio González Sarmiento
[This corrects the article DOI: 10.1371/journal.pone.0156317.].
2017: PloS One
https://www.readbyqxmd.com/read/28070667/erratum-to-regional-citrate-anticoagulation-for-continuous-renal-replacement-therapy-in-children
#9
Mayerly Prada Rico, Jaime Fernández Sarmiento, Ana María Rojas Velasquez, Luz Stella González Chaparro, Ricardo Gastelbondo Amaya, Hernando Mulett Hoyos, Daniel Tibaduiza, Ana Maria Quintero Gómez
No abstract text is available yet for this article.
January 9, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27992614/a-single-nucleotide-polymorphism-in-the-rasgrf2-gene-is-associated-with-alcoholic-liver-cirrhosis-in-men
#10
Ignacio Novo-Veleiro, Clara Cieza-Borrella, Isabel Pastor, Antonio-Javier Chamorro, Francisco-Javier Laso, Rogelio González-Sarmiento, Miguel Marcos
BACKGROUND: Genetic polymorphisms in the RAS gene family are associated with different diseases, which may include alcohol-related disorders. Previous studies showed an association of the allelic variant rs26907 in RASGRF2 gene with higher alcohol intake. Additionally, the rs61764370 polymorphism in the KRAS gene is located in a binding site for the let-7 micro-RNA family, which is potentially involved in alcohol-induced inflammation. Therefore, this study was designed to explore the association between these two polymorphisms and susceptibility to alcoholism or alcoholic liver disease (ALD)...
2016: PloS One
https://www.readbyqxmd.com/read/27987438/unsupervised-analysis-of-array-comparative-genomic-hybridization-data-from-early-onset-colorectal-cancer-reveals-equivalence-with-molecular-classification-and-phenotypes
#11
María Arriba, Juan L García, Daniel Rueda, Jessica Pérez, Lorena Brandariz, Oana A Nutu, Laura Alonso, Yolanda Rodríguez, Miguel Urioste, Rogelio González-Sarmiento, José Perea
AIM: To investigate whether chromosomal instability (CIN) is associated with tumor phenotypes and/or with global genomic status based on MSI (microsatellite instability) and CIMP (CpG island methylator phenotype) in early-onset colorectal cancer (EOCRC). METHODS: Taking as a starting point our previous work in which tumors from 60 EOCRC cases (≤45 years at the time of diagnosis) were analyzed by array comparative genomic hybridization (aCGH), in the present study we performed an unsupervised hierarchical clustering analysis of those aCGH data in order to unveil possible associations between the CIN profile and the clinical features of the tumors...
December 14, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27960588/investigation-of-association-between-autophagy-related-gene-polymorphisms-and-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma-in-a-spanish-population
#12
Lourdes de Juan-Marcos, Francisco A Escudero-Domínguez, Emiliano Hernández-Galilea, Fernando Cruz-González, Isora Follana-Neira, Rogelio González-Sarmiento
PURPOSE: Cellular stress conditions are important mechanisms implicated in the pathogenesis of pseudoexfoliation syndrome. One of the potential cellular responses to these stress conditions is induction of autophagy. The purpose of this study was to evaluate whether genetic variants in three critical genes of autophagy (ATG16L, ATG2B, ATG5) may be involved in the development of pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) in a Spanish population. METHODS: 108 patients (64 XFS, 44XFG) and 118 healthy controls were evaluated...
December 14, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27938998/epidermal-growth-factor-receptor-egfr-pathway-polymorphisms-as-predictive-markers-of-cetuximab-toxicity-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-in-a-spanish-population
#13
J Fernández-Mateos, R Seijas-Tamayo, R Mesía, M Taberna, M Pastor Borgoñón, E Pérez-Ruiz, J C Adansa Klain, S Vázquez Fernández, E Del Barco Morillo, A Lozano, R González Sarmiento, J J Cruz-Hernández
OBJECTIVES: To examine the relationship between polymorphisms of the epidermal growth factor receptor (EGFR) pathway and toxicity in head and neck squamous cell carcinoma (HNSCC) patients treated with cetuximab. MATERIAL AND METHODS: Multicenter, retrospective, observational pilot study which included 110 patients with histologically-confirmed human papillomavirus (HPV) negative HNSCC in locally advanced stages (III-IVA-B) and who were treated with chemotherapy and radiotherapy plus cetuximab between 2003 and 2013...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27925748/role-of-the-%C3%AE-resonance-in-the-population-of-a-four-nucleon-state-in-the-56-fe%C3%A2-54-fe-reaction-at-relativistic-energies
#14
Zs Podolyák, C M Shand, N Lalović, J Gerl, D Rudolph, T Alexander, P Boutachkov, M L Cortés, M Górska, I Kojouharov, N Kurz, C Louchart, E Merchán, C Michelagnoli, R M Pérez-Vidal, S Pietri, D Ralet, M Reese, H Schaffner, Ch Stahl, H Weick, F Ameil, G de Angelis, T Arici, R Carroll, Zs Dombrádi, A Gadea, P Golubev, M Lettmann, C Lizarazo, D Mahboub, H Pai, Z Patel, N Pietralla, P H Regan, L G Sarmiento, O Wieland, E Wilson, B Birkenbach, B Bruyneel, I Burrows, L Charles, E Clément, F C L Crespi, D M Cullen, P Désesquelles, J Eberth, V González, T Habermann, L Harkness-Brennan, H Hess, D S Judson, A Jungclaus, W Korten, M Labiche, A Maj, D Mengoni, D R Napoli, A Pullia, B Quintana, G Rainovski, P Reiter, M D Salsac, E Sanchis, J J Valiente Dóbon
The ^{54}Fe nucleus was populated from a ^{56}Fe beam impinging on a Be target with an energy of E/A=500  MeV. The internal decay via γ-ray emission of the 10^{+} metastable state was observed. As the structure of this isomeric state has to involve at least four unpaired nucleons, it cannot be populated in a simple two-neutron removal reaction from the ^{56}Fe ground state. The isomeric state was produced in the low-momentum (-energy) tail of the parallel momentum (energy) distribution of ^{54}Fe, suggesting that it was populated via the decay of the Δ^{0} resonance into a proton...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27896442/regional-citrate-anticoagulation-for-continuous-renal-replacement-therapy-in-children
#15
Mayerly Prada Rico, Jaime Fernández Sarmiento, Ana María Rojas Velasquez, Luz Stella González Chaparro, Ricardo Gastelbondo Amaya, Hernando Mulett Hoyos, Daniel Tibaduiza, Ana Maria Quintero Gómez
BACKGROUND: Anticoagulation of the continuous renal replacement therapy (CRRT) circuit is an important technical aspect of this medical procedure. Most studies evaluating the efficacy and safety of citrate use have been carried out in adults, and little evidence is available for the pediatric patient population. The aim of this study was to compare regional citrate anticoagulation versus systemic heparin anticoagulation in terms of the lifetime of hemofilters in a pediatric population receiving CRRT at a pediatric center in Bogota, Colombia...
November 28, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27892735/delivery-route-determines-the-presence-of-immune-complexes-on-umbilical-cord-erythrocytes
#16
Andrés de Lima, Luis C Franco, Andrés Sarmiento, John M González
OBJECTIVE: Umbilical cord blood offers a unique opportunity to study the basal level of immunoglobulin complexes. This study aims to determine the presence of immune complexes and complement deposition on erythrocytes from umbilical cord blood from normal, full-term pregnancies. METHODS: In vitro pre-formed IgA, IgG, and IgM complexes were used as positive control for flow cytometry detection, and for C3d deposition. Blood samples (34) of umbilical cord blood taken from vaginal and cesarean deliveries were tested for the presence of immunoglobulin complexes...
November 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27858429/testing-hadronic-interactions-at-ultrahigh-energies-with-air-showers-measured-by-the-pierre-auger-observatory
#17
A Aab, P Abreu, M Aglietta, E J Ahn, I Al Samarai, I F M Albuquerque, I Allekotte, J D Allen, P Allison, A Almela, J Alvarez Castillo, J Alvarez-Muñiz, M Ambrosio, G A Anastasi, L Anchordoqui, B Andrada, S Andringa, C Aramo, F Arqueros, N Arsene, H Asorey, P Assis, J Aublin, G Avila, A M Badescu, C Baus, J J Beatty, K H Becker, J A Bellido, C Berat, M E Bertaina, X Bertou, P L Biermann, P Billoir, J Biteau, S G Blaess, A Blanco, J Blazek, C Bleve, H Blümer, M Boháčová, D Boncioli, C Bonifazi, N Borodai, A M Botti, J Brack, I Brancus, T Bretz, A Bridgeman, F L Briechle, P Buchholz, A Bueno, S Buitink, M Buscemi, K S Caballero-Mora, B Caccianiga, L Caccianiga, A Cancio, F Canfora, L Caramete, R Caruso, A Castellina, G Cataldi, L Cazon, R Cester, A G Chavez, A Chiavassa, J A Chinellato, J C Chirinos Diaz, J Chudoba, R W Clay, R Colalillo, A Coleman, L Collica, M R Coluccia, R Conceição, F Contreras, M J Cooper, S Coutu, C E Covault, J Cronin, R Dallier, S D'Amico, B Daniel, S Dasso, K Daumiller, B R Dawson, R M de Almeida, S J de Jong, G De Mauro, J R T de Mello Neto, I De Mitri, J de Oliveira, V de Souza, J Debatin, L Del Peral, O Deligny, N Dhital, C Di Giulio, A Di Matteo, M L Díaz Castro, F Diogo, C Dobrigkeit, J C D'Olivo, A Dorofeev, R C Dos Anjos, M T Dova, A Dundovic, J Ebr, R Engel, M Erdmann, M Erfani, C O Escobar, J Espadanal, A Etchegoyen, H Falcke, K Fang, G R Farrar, A C Fauth, N Fazzini, A P Ferguson, B Fick, J M Figueira, A Filevich, A Filipčič, O Fratu, M M Freire, T Fujii, A Fuster, F Gallo, B García, D Garcia-Pinto, F Gate, H Gemmeke, A Gherghel-Lascu, P L Ghia, U Giaccari, M Giammarchi, M Giller, D Głas, C Glaser, H Glass, G Golup, M Gómez Berisso, P F Gómez Vitale, N González, B Gookin, J Gordon, A Gorgi, P Gorham, P Gouffon, N Griffith, A F Grillo, T D Grubb, F Guarino, G P Guedes, M R Hampel, P Hansen, D Harari, T A Harrison, J L Harton, Q Hasankiadeh, A Haungs, T Hebbeker, D Heck, P Heimann, A E Herve, G C Hill, C Hojvat, N Hollon, E Holt, P Homola, J R Hörandel, P Horvath, M Hrabovský, T Huege, J Hulsman, A Insolia, P G Isar, I Jandt, S Jansen, C Jarne, J A Johnsen, M Josebachuili, A Kääpä, O Kambeitz, K H Kampert, P Kasper, I Katkov, B Keilhauer, E Kemp, R M Kieckhafer, H O Klages, M Kleifges, J Kleinfeller, R Krause, N Krohm, D Kuempel, G Kukec Mezek, N Kunka, A Kuotb Awad, D LaHurd, L Latronico, M Lauscher, P Lautridou, P Lebrun, R Legumina, M A Leigui de Oliveira, A Letessier-Selvon, I Lhenry-Yvon, K Link, L Lopes, R López, A López Casado, A Lucero, M Malacari, M Mallamaci, D Mandat, P Mantsch, A G Mariazzi, V Marin, I C Mariş, G Marsella, D Martello, H Martinez, O Martínez Bravo, J J Masías Meza, H J Mathes, S Mathys, J Matthews, J A J Matthews, G Matthiae, D Maurizio, E Mayotte, P O Mazur, C Medina, G Medina-Tanco, V B B Mello, D Melo, A Menshikov, S Messina, M I Micheletti, L Middendorf, I A Minaya, L Miramonti, B Mitrica, L Molina-Bueno, S Mollerach, F Montanet, C Morello, M Mostafá, C A Moura, G Müller, M A Muller, S Müller, I Naranjo, S Navas, P Necesal, L Nellen, A Nelles, J Neuser, P H Nguyen, M Niculescu-Oglinzanu, M Niechciol, L Niemietz, T Niggemann, D Nitz, D Nosek, V Novotny, H Nožka, L A Núñez, L Ochilo, F Oikonomou, A Olinto, D Pakk Selmi-Dei, M Palatka, J Pallotta, P Papenbreer, G Parente, A Parra, T Paul, M Pech, F Pedreira, J Pękala, R Pelayo, J Peña-Rodriguez, I M Pepe, L A S Pereira, L Perrone, E Petermann, C Peters, S Petrera, J Phuntsok, R Piegaia, T Pierog, P Pieroni, M Pimenta, V Pirronello, M Platino, M Plum, C Porowski, R R Prado, P Privitera, M Prouza, E J Quel, S Querchfeld, S Quinn, J Rautenberg, O Ravel, D Ravignani, B Revenu, J Ridky, M Risse, P Ristori, V Rizi, W Rodrigues de Carvalho, J Rodriguez Rojo, M D Rodríguez-Frías, D Rogozin, J Rosado, M Roth, E Roulet, A C Rovero, S J Saffi, A Saftoiu, H Salazar, A Saleh, F Salesa Greus, G Salina, J D Sanabria Gomez, F Sánchez, P Sanchez-Lucas, E M Santos, E Santos, F Sarazin, B Sarkar, R Sarmento, C Sarmiento-Cano, R Sato, C Scarso, M Schauer, V Scherini, H Schieler, D Schmidt, O Scholten, H Schoorlemmer, P Schovánek, F G Schröder, A Schulz, J Schulz, J Schumacher, S J Sciutto, A Segreto, M Settimo, A Shadkam, R C Shellard, G Sigl, O Sima, A Śmiałkowski, R Šmída, G R Snow, P Sommers, S Sonntag, J Sorokin, R Squartini, D Stanca, S Stanič, J Stapleton, J Stasielak, F Strafella, A Stutz, F Suarez, M Suarez Durán, T Sudholz, T Suomijärvi, A D Supanitsky, M S Sutherland, J Swain, Z Szadkowski, O A Taborda, A Tapia, A Tepe, V M Theodoro, C Timmermans, C J Todero Peixoto, L Tomankova, B Tomé, A Tonachini, G Torralba Elipe, D Torres Machado, P Travnicek, M Trini, R Ulrich, M Unger, M Urban, A Valbuena-Delgado, J F Valdés Galicia, I Valiño, L Valore, G van Aar, P van Bodegom, A M van den Berg, A van Vliet, E Varela, B Vargas Cárdenas, G Varner, J R Vázquez, R A Vázquez, D Veberič, V Verzi, J Vicha, M Videla, L Villaseñor, S Vorobiov, H Wahlberg, O Wainberg, D Walz, A A Watson, M Weber, A Weindl, L Wiencke, H Wilczyński, T Winchen, D Wittkowski, B Wundheiler, S Wykes, L Yang, T Yapici, D Yelos, E Zas, D Zavrtanik, M Zavrtanik, A Zepeda, B Zimmermann, M Ziolkowski, Z Zong, F Zuccarello
Ultrahigh energy cosmic ray air showers probe particle physics at energies beyond the reach of accelerators. Here we introduce a new method to test hadronic interaction models without relying on the absolute energy calibration, and apply it to events with primary energy 6-16 EeV (E_{CM}=110-170  TeV), whose longitudinal development and lateral distribution were simultaneously measured by the Pierre Auger Observatory. The average hadronic shower is 1.33±0.16 (1.61±0.21) times larger than predicted using the leading LHC-tuned models EPOS-LHC (QGSJetII-04), with a corresponding excess of muons...
November 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27848732/results-from-colombia-s-2016-report-card-on-physical-activity-for-children-and-youth
#18
Silvia A González, Maria A Castiblanco, Luis F Arias-Gómez, Andrea Martinez-Ospina, Daniel D Cohen, Gustavo A Holguin, Adriana Almanza, Diana Marina Camargo Lemos, Jorge Enrique Correa-Bautista, Iván D Escobar, Johnattan García, Rocio Gámez, Mauricio Garzon, Yaneth Herazo Beltrán, Hernan Hurtado, Oscar Lozano, Diana C Páez, Robinson Ramírez-Vélez, Nubia Ruiz, Gustavo Tovar, Olga L Sarmiento
BACKGROUND: Physical activity (PA) is vital to the holistic development of young people. Regular participation in PA is associated with substantial benefits for health, cognitive function, and social inclusion. Recognizing the potential of PA in the context of the current peace process in Colombia, the purpose of this article is to present the methodology and results of Colombia's second Report Card on PA for children and youth. METHODS: A group of experts on PA graded 14 PA indicators based on data from national surveys and policy documents...
November 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27672596/influence-of-cfh-htra1-and-arms2-polymorphisms-in-the-response-to-intravitreal-ranibizumab-treatment-for-wet-age-related-macular-degeneration-in-a-spanish-population
#19
Fernando Cruz-Gonzalez, Lucia Cabrillo-Estevez, Vanesa Rivero-Gutierrez, Ana Sanchez-Jara, Lourdes De Juan-Marcos, Rogelio Gonzalez-Sarmiento
AIM: To determine whether gene polymorphisms of the major genetic risk loci for age-related macular degeneration (AMD): ARMS2 (rs10490923), the complement factor H (CFH) (rs1410996) and HTRA1 (rs11200638) influence the response to a treatment regimen with ranibizumab for exudative AMD. METHODS: This study included 100 patients (100 eyes) with exudative AMD. Patients underwent a treatment with ranibizumab injections monthly during three months. Reinjections were made when the best corrected visual acuity (BCVA) decrease five letters (ETDRS) or central subfield retinal thickness gained 100 µm in optical coherence tomography image...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27614749/pharmacological-potential-of-phylogenetically-diverse-actinobacteria-isolated-from-deep-sea-coral-ecosystems-of-the-submarine-avil%C3%A3-s-canyon-in-the-cantabrian-sea
#20
Aida Sarmiento-Vizcaíno, Verónica González, Alfredo F Braña, Juan J Palacios, Luis Otero, Jonathan Fernández, Axayacatl Molina, Andreas Kulik, Fernando Vázquez, José L Acuña, Luis A García, Gloria Blanco
Marine Actinobacteria are emerging as an unexplored source for natural product discovery. Eighty-seven deep-sea coral reef invertebrates were collected during an oceanographic expedition at the submarine Avilés Canyon (Asturias, Spain) in a range of 1500 to 4700 m depth. From these, 18 cultivable bioactive Actinobacteria were isolated, mainly from corals, phylum Cnidaria, and some specimens of phyla Echinodermata, Porifera, Annelida, Arthropoda, Mollusca and Sipuncula. As determined by 16S rRNA sequencing and phylogenetic analyses, all isolates belong to the phylum Actinobacteria, mainly to the Streptomyces genus and also to Micromonospora, Pseudonocardia and Myceligenerans...
September 10, 2016: Microbial Ecology
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