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JOURNAL ARTICLE
Philipp K Zuber, Nelly Said, Tarek Hilal, Bing Wang, Bernhard Loll, Jorge González-Higueras, César A Ramírez-Sarmiento, Georgiy A Belogurov, Irina Artsimovitch, Markus C Wahl, Stefan H Knauer
RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the RNAP-binding site. Upon recruitment to RNAP paused at an ops site, KOW is released and refolds into a β-barrel, which binds the ribosome. Here, we report structures of ops-paused transcription elongation complexes alone and bound to the autoinhibited and activated RfaH, which reveal swiveled, pre-translocated pause states stabilized by an ops hairpin in the non-template DNA...
April 8, 2024: Nature Communications
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JOURNAL ARTICLE
Beatriz León-Salas, Amaia Bilbao-González, Ana María de Pascual Y Medina, Magdalena Esteva, Ana Toledo-Chávarri, Claudio Fuentes-Sánchez, Uriel Bohn-Sarmiento, Pilar Padrón-Peña, Sonia González-Sánchez, Rafael Valcárcel-López, María Del Mar Trujillo-Martín
PURPOSE: The aim of this study was to translate, culturally adapt, and evaluate the psychometric properties of the Spanish Long-Term Quality of Life (LTQL) questionnaire. METHODS: The LTQL was initially translated into Spanish and cross-culturally adapted based on established guidelines. The Spanish LTQL was administered to patients with breast cancer who had completed their initial treatment 5 years earlier, along with other self-report measures: Quality of Life in Adult Cancer Survivors (QLACS), Hospital Anxiety and Depression Scale (HADS) and EORT-QLQ-BR23...
2024: Frontiers in Oncology
#3
JOURNAL ARTICLE
Virginia McKay, Yichen Chen, Kim Prewitt, Sara Malone, Maria Puerto-Torres, Carlos Acuña-Aguirre, Yvania Alfonso-Carreras, Shilel Y Alvarez-Arellano, Leticia A Andrade-Sarmiento, Daniela Arce-Cabrera, Deiby Argüello-Vargas, Mariuxy D C Barragán-García, Rosario Batista-Del-Cid, Erika E Blasco-Arriaga, Maria D C Cach-Castaneda, Gloria I Ceballo-Batista, Mayra Chávez-Rios, Maria E Costa, Maria E Cuencio-Rodriguez, Rosdali Diaz-Coronado, Ever A Fing-Soto, Teresa D J García-Sarmiento, Wendy C Gómez-García, Cinthia J Hernández-González, Yajaira V Jimenez-Antolinez, Maria S Juarez-Tobias, Esmeralda M León-López, Norma A Lopez-Facundo, Ruth A Martínez Soria, Scheybi T Miralda-Méndez, Erika Montalvo, Carlos M Pérez-Alvarado, Clara K Perez-Fermin, Monica L Quijano-Lievano, Beatriz Salas-Mendoza, Edwin E Sanchez-Fuentes, Marcia X Serrano-Landivar, Veronica Soto-Chavez, Isidoro Tejocote-Romero, Sergio Valle, Elizabeth A Vasquez-Roman, Juliana Texeira Costa, Adolfo Cardenas-Aguirre, Meenakshi Devidas, Douglas A Luke, Asya Agulnik
Clinical capacity for sustainability, or the clinical resources needed to sustain an evidence-based practice, represent proximal determinants that contribute to intervention sustainment. We examine the relationship between clinical capacity for sustainability and sustainment of PEWS, an evidence-based intervention to improve outcomes for pediatric oncology patients in resource-variable hospitals. We conducted a cross-sectional survey among Latin American pediatric oncology centers participating in Proyecto Escala de Valoración de Alerta Temprana (EVAT), an improvement collaborative to implement Pediatric Early Warning Systems (PEWS)...
March 2024: Glob Implement Res Appl
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JOURNAL ARTICLE
Alondra Concepción-González, J Manuel Sarmiento, Christina C Rymond, Chinenye Ezeh, Rishi Sinha, Hannah Lin, Kevin Lu, Afrain Z Boby, Prakash Gorroochurn, A Noelle Larson, Benjamin D Roye, Brice Ilharreborde, Michael G Vitale
PURPOSE: In 2018, Best Practice Guidelines (BPGs) were published for preventing wrong-level surgery in pediatric spinal deformity, but successful implementation has not been established. The purpose of this study was to evaluate BPG compliance 5 years after publication. We hypothesized higher compliance among BPG authors and among surgeons with more experience, higher caseload, and awareness of the BPGs. METHODS: We queried North American and European surgeons, authors and nonauthors, and members of pediatric spinal study groups on adherence to BPGs using an anonymous survey consisting of 18 Likert scale questions...
March 21, 2024: Spine Deformity
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JOURNAL ARTICLE
José Perea, Juan Luis García, Luis A Corchete, Marc Martí, Sergio Hernández-Villafranca, José A Alcázar, Edurne Álvaro, Elena Hurtado, Marta Jiménez-Toscano, Francesc Balaguer, Araceli Ballestero, Irene López-Rojo, Fernando Jiménez, Gonzalo Sanz, Sirio Melone, Lorena Brandáriz, Alfredo Vivas, Alicia Alvarellos, Rogelio González-Sarmiento
No abstract text is available yet for this article.
March 2, 2024: British Journal of Surgery
#6
JOURNAL ARTICLE
Diana Sarmiento Quintana, Inmaculada Morales Fariña, Jéssica González Pérez, José Raduan Jaber, Juan Alberto Corbera
This study investigated the prevalence of pigmentary keratitis (PK) in Pug-breed dogs and described the ocular surface characteristics associated with this disease. A total of 219 eyes from 110 dogs were examined, with 94.5% of them affected by PK. Age, previous ocular diseases, corneal vascularization, and corneal sensitivity were significantly associated with the presence of PF and the severity of corneal pigmentation. The study also found that low tear production and blinks incomplete with tear signs, as well as reduced corneal sensitivity, were linked to more severe forms of corneal pigmentation...
February 9, 2024: Animals: An Open Access Journal From MDPI
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JOURNAL ARTICLE
Pablo Díaz-Calvillo, Carmen Gómez-Jiménez, Doriane Sabushimike, Rogelio González-Sarmiento, Mónica Roncero-Riesco, Ángel Santos-Briz
No abstract text is available yet for this article.
March 1, 2024: American Journal of Dermatopathology
#8
JOURNAL ARTICLE
María Inés Sarmiento-Medina, Miryam Puerto de Amaya, Licet Villamizar-Gómez, Andrea Carolina González-Coba, Laura Guzmán-Barajas
Cervical cancer, primarily caused by Human Papillomavirus (HPV) transmission through sexual contact, necessitates comprehensive strategies to combat its impact on women's health. Yet, certain underserved populations, such as low socioeconomic and ethnic minority groups, encounter barriers in accessing timely interventions and early diagnosis. This cross-sectional study was conducted with the aim of assessing HPV prevalence, genotype distribution, and co-infections among 280 adult women residing in a Colombian Indigenous Reserve within the Amazon region...
2024: PloS One
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JOURNAL ARTICLE
Graciela Cárdenas, María Chávez-Canales, Ana María Espinosa, Antonio Jordán-Ríos, Daniel Anica Malagon, Manlio Fabio Márquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos, Rosa María Wong-Chew, Luis Esteban Ramirez González, Karent Ibet Cresencio, Enrique García Velázquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernández-Ruiz, María Luisa Hernández-Medel, Mireya León-Hernández, Karen Medina Quero, Anahí Sánchez Monciváis, Eduardo Beltrán Sarmiento, Rafael Ignacio Aguilar Reynoso, Daniela Murillo Reyes, Luis Rodrigo Del Río Ambriz, Juan Salvador García Hernández, Jocelyn Cruz, Sergio Iván Valdés Ferrer, Leonor Huerta, Nora Alma Fierro, Marisela Hernández, Mayra Pérez-Tapia, Gabriela Meneses, Gabriela Rosas, Juan Alberto Hernández-Aceves, Jaquelynne Cervantes-Torres, Ricardo A Valdez, Anai Fuentes Rodríguez, Erick Espíndola-Arriaga, Mauricio Ortiz, Evelyn Alvarez Salazar, Carlos Castellanos Barba, Hugo Besedovsky, Marta C Romano, Helgi Jung, Raúl J Bobes, Gloria Soldevila, Juan C López-Alvarenga, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto
BACKGROUND: SARS-CoV2 induces flu-like symptoms that can rapidly progress to severe acute lung injury and even death. The virus also invades the central nervous system (CNS), causing neuroinflammation and death from central failure. Intravenous (IV) or oral dexamethasone (DXM) reduced 28 d mortality in patients who required supplemental oxygen compared to those who received conventional care alone. Through these routes, DMX fails to reach therapeutic levels in the CNS. In contrast, the intranasal (IN) route produces therapeutic levels of DXM in the CNS, even at low doses, with similar systemic bioavailability...
January 29, 2024: Archives of Medical Research
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REVIEW
Juan Luis Sánchez-González, Juan Luis Sánchez-Rodríguez, Sergio Varela-Rodríguez, Rogelio González-Sarmiento, Cristina Rivera-Picón, Raúl Juárez-Vela, Clara Isabel Tejada-Garrido, Javier Martín-Vallejo, Víctor Navarro-López
BACKGROUND: Physical exercise is one of the main nonpharmacological treatments for most pathologies. In addition, physical exercise is beneficial in the prevention of various diseases. The impact of physical exercise has been widely studied; however, existing meta-analyses have included diverse and heterogeneous samples. Therefore, to our knowledge, this is the first meta-analysis to evaluate the impact of different physical exercise modalities on telomere length in healthy populations...
January 9, 2024: JMIR Public Health and Surveillance
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JOURNAL ARTICLE
Diego A Sánchez Cruz, Manuel Mosquera, Luciano A Rossi, Paul Patiño, Roberto Yukio Ikemoto, Jorge Rengifo Miguel, Fernando S Valero-González, Pablo Vargas C, Christian M Lozano, Paulo J Llinas H, Byron Torres, Daniel Slullitel, Diego Albertengo, Diego Rivera Sarmiento, Fabio Restrepo, Fernando Alcides, Fernando Barclay, Gustavo Hernandez, Hernando Canal, Jairo Villa, Marcela Piña, Marcio Cohen, Mauricio Largacha, Sergio Echeverry
OBJECTIVES: To implement the Formal Consensus Method among a group of experts in shoulder surgery in Latin America, in order to establish appropriate indications for the surgical treatment of a massive and irreparable rotator cuff injuries. METHODS: The Formal Consensus Method was used to develop surgical treatment recommendations for a massive and irreparable rotator cuff tears (MIRCT). Three independent groups of experts in shoulder surgery were conformed. The steering group conducted a systematic literature review and constructed a voting matrix consisting of 348 clinical scenarios...
January 4, 2024: Journal of ISAKOS
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JOURNAL ARTICLE
Ayelet I Rubenstein, Sheila K Pierson, Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Michael V Gonzalez, Ira D Milller, Joshua D Brandstadter, Melanie D Mumau, David C Fajgenbaum
Idiopathic multicentric Castleman disease (iMCD) is a rare haematological disorder characterized by generalized lymphadenopathy with atypical histopathological features and systemic inflammation caused by a cytokine storm involving interleukin-6 (IL-6). Three clinical subtypes are recognized: thrombocytopenia, anasarca, fever, renal dysfunction, organomegaly (iMCD-TAFRO); idiopathic plasmacytic lymphadenopathy (iMCD-IPL), involving thrombocytosis and hypergammaglobulinaemia; and iMCD-not otherwise specified (iMCD-NOS), which includes patients who do not meet criteria for the other subtypes...
March 2024: British Journal of Haematology
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JOURNAL ARTICLE
Jaime Fernández-Sarmiento, Marco Fidel Sierra-Zuñiga, María Paula Salazar González, Natalia Lucena, Vanessa Soares Lanziotti, Sergio Agudelo
BACKGROUND: Sepsis is one of the main causes of morbidity and mortality worldwide. Fluid resuscitation is among the most common interventions and is associated with fluid overload (FO) in some patients. The objective of this systematic review and meta-analysis was to summarise the available evidence on the association between FO and morbimortality in children with sepsis. METHODS: A systematic search was carried out in PubMed/Medline, Embase, Cochrane and Google Scholar up to December 2022 (PROSPERO 408148), including studies in children with sepsis which reported more than 10% FO 24 hours after admission to intensive care...
November 2023: BMJ Paediatrics Open
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JOURNAL ARTICLE
Diana Moroni-González, Victor Enrique Sarmiento-Ortega, Alfonso Diaz, Eduardo Brambila, Samuel Treviño
Cadmium, a hazardous environmental contaminant, is associated with metabolic disease development. The dose with the lowest observable adverse effect level (LOAEL) has not been studied, focusing on its effect on the pancreas. We aimed to evaluate the pancreatic redox balance and heat shock protein (HSP) expression in islets of Langerhans of male Wistar rats chronically exposed to Cd LOAEL doses, linked to their survival. Male Wistar rats were separated into control and cadmium groups (drinking water with 32...
November 13, 2023: Biological Trace Element Research
#15
JOURNAL ARTICLE
Silvia A González, Deepti Adlakha, Santiago Cabas, Sharon C Sánchez-Franco, Maria A Rubio, Natalia Ossa, Paola A Martínez, Nathally Espinosa, Olga L Sarmiento
The community restrictions during the coronavirus disease 2019 pandemic adversely impacted older adults' physical activity levels. This convergent mixed-method study assessed the adaptation of the Recreovía, a community-based physical activity program in Bogotá, and characterized physical activity levels among older adult participants. Our results showed how the Recreovía adapted during the pandemic to continue promoting physical activity, through indoor and outdoor strategies, including virtual physical activity sessions and safety protocols...
October 26, 2023: Journal of Aging and Physical Activity
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REVIEW
Yasna K Palmeiro-Silva, Marisol Yglesias-González, Luciana Blanco-Villafuerte, Katya Canal-Solis, Ricardo Castillo Neyra, Daniel Fernández-Guzmán, Juliana Helo Sarmiento, Romina Lavarello, Andrés G Lescano, Oscar Melo, Valerie A Paz Soldán, David Rojas-Rueda, Marina Romanello, María Fernanda Salas, Bruno Takahashi, Ariana Valcárcel, Daniel Buss, Stella Hartinger
South America is experiencing the effects of climate change, including extreme weather events and changes in temperature and precipitation patterns. These effects interact with existing social vulnerabilities, exacerbating their impact on the health and wellbeing of populations. This viewpoint highlights four main messages from the series, which presented key gaps from five different perspectives of health and climate. First, there is an overall need for local analyses of priority topics to inform public policy, which include national and sub-national evidence to adequately strengthen responses and preparedness for climate change hazards and address relevant social vulnerabilities in South American countries...
October 2023: Lancet Reg Health Am
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JOURNAL ARTICLE
Adriana Yock-Corrales, Jan Hau Lee, Jesús Ángel Domínguez-Rojas, Paula Caporal, Juan D Roa, Jaime Fernandez-Sarmiento, Sebastián González-Dambrauskas, Yanan Zhu, Qalab Abbas, Yasser Kazzaz, Dianna Sri Dewi, Shu-Ling Chong
INTRODUCTION: We aimed to identify clinical characteristics, risk factors for diagnosis, and describe outcomes among children with AHT. METHODS: We performed an observational cohort study in tertiary care hospitals from 14 countries across Asia and Ibero-America. We included patients <5 years old who were admitted to participating pediatric intensive care units (PICUs) with moderate to severe traumatic brain injury (TBI). We performed descriptive analysis and multivariable logistic regression for risk factors of AHT...
September 30, 2023: Journal of Pediatric Surgery
#18
JOURNAL ARTICLE
Lorena Rodriguez-Martinez, Cristina García-Moreno, Eva Perez-Pampin, María J Gómara, Juan C Sarmiento-Monroy, Yolanda Lopez-Golán, José A Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro, Antonio González
BACKGROUND: Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for all RA patients, including those lacking RF and anti-CCP antibodies. Therefore, we aimed to replicate these findings. METHODS: We independently attempted replication in Santiago and Barcelona using sera from 517 and 178 RA patients and 272 and 120 healthy controls, respectively...
October 5, 2023: Arthritis Research & Therapy
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JOURNAL ARTICLE
Francisco Javier González-Eslait, Pedro Abel Blanco-Sarmiento, Kabethliz Bejarano-Domínguez, José María Barreto, Emelina Ruiz-Tejada
No abstract text is available yet for this article.
October 2, 2023: Journal of Laryngology and Otology
#20
Mónica Cano-Rosás, Joaquín de Vicente-Jiménez, José María Diosdado-Cano, David Suárez-Quintanilla, Rogelio González-Sarmiento, Daniel Curto, Adrián Curto
We present the clinical course of a 9-year-old female patient with Bloch-Sulzberger syndrome and severe neurological deficit that met the major (classic cutaneous signs) and minor (dental anomalies and retinal pathology) diagnostic criteria of Landy and Donnai. Longitudinal multidisciplinary follow-up was carried out from birth to adulthood. Neurological involvement was assessed with electroencephalographic (EEG) and neuroimaging tests at different times during the patient's life. Cranio-maxillofacial involvement was evaluated using lateral skeletal facial and cephalometric analyses...
September 4, 2023: Children
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