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https://www.readbyqxmd.com/read/29749392/corrigendum-association-of-vav2-and-vav3-polymorphisms-with-cardiovascular-risk-factors
#1
Nuria Perretta-Tejedor, Javier Fernández-Mateos, Luis García-Ortiz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, Cristina Agudo-Conde, Emiliano Rodriguez-Sánchez, Ana I Morales, Francisco J López-Hernández, José M López-Novoa, Rogelio González-Sarmiento, Carlos Martínez-Salgado
This corrects the article DOI: 10.1038/srep41875.
May 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29656095/a-protocol-of-human-animal-interaction-to-habituate-young-sheep-and-goats-for-behavioural-studies
#2
P G González-Pech, C G Marín-Tun, D A Valladares-González, J Ventura-Cordero, G I Ortiz-Ocampo, R Cámara-Sarmiento, C Sandoval-Castro, J F J Torres-Acosta
Animal habituation is key to obtain reliable data on behavioural studies but detailed procedures to achieve it are scarce. This study designed a set of actions to habituate sheep and goats to human observers. Pelibuey sheep (n = 15) and Criollo goats (n = 10) were classified as (a) avoider, flight from human interaction, or (b) follower, seek human interaction. Habituation was measured by the reduction of flight distance by avoiders, or number of followers in the presence of observers. The habituation protocol consisted of a gradually increased series of five manoeuvres, either challenge (for avoiders) or evasion (for seekers), performed first inside a pen and subsequently in a grass paddock...
April 12, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29589192/utilization-of-mucuna-pruriens-whole-pods-to-feed-lactating-hair-ewes
#3
Irina Nadieska Peniche-Gonzalez, Luis Armando Sarmiento-Franco, Ronald Herve Santos-Ricalde
Twenty nine Pelibuey × Katahdin hair ewes rearing single lamb were used during 42 days of lactation to evaluate the effect of including the Mucuna pruriens whole pods in the diets of lactating ewes on milk production and offspring performance. Animals were distributed at random into three experimental diets: a control diet without Mucuna (M0), and two more diets with the inclusion of 13 (M13) and 26% (M26), of milled pods of Mucuna pruriens, respectively. Dry matter intake, was not significantly different (P > 0...
March 27, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29566963/analysis-of-the-relationship-between-interleukin-polymorphisms-within-mirna-binding-regions-and-alcoholic-liver-disease
#4
I Novo-Veleiro, C Cieza-Borrella, I Pastor, Rogelio González-Sarmiento, F-J Laso, M Marcos
INTRODUCTION: Alcohol consumption promotes inflammation through the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway, leading to organic damage. Some micro-RNA (miRNA) molecules modulate this inflammatory response by downregulating TLR4/NF-κB pathway mediators, like interleukins (ILs). Thus, polymorphisms within IL genes located near miRNA binding sites could modify the risk of ethanol-induced damage. The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms...
March 19, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29479337/successful-treatment-of-a-drug-resistant-epilepsy-by-long-term-transcranial-direct-current-stimulation-a-case-report
#5
Daniel San-Juan, Carlos Ignacio Sarmiento, Katia Márquez González, José Manuel Orenday Barraza
Transcranial direct current stimulation (tDCS) is a reemerged noninvasive cerebral therapy used to treat patients with epilepsy, including focal cortical dysplasia, with controversial results. We present a case of a 28-year-old female with left frontal cortical dysplasia refractory to antiepileptic drugs, characterized by 10-15 daily right tonic hemi-body seizures. The patient received a total of seven sessions of cathodal tDCS (2 mA, 30 min). The first three sessions were applied over three consecutive days, and the remaining four sessions of tDCS were given each at 2-week intervals...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29384528/comment-on-distinct-clinical-outcomes-of-two-cimp-positive-colorectal-cancer-subtypes-based-on-a-revised-cimp-classification-system
#6
Sandra Tapial, Daniel Rueda, María Arriba, Juan Luis García, Lorena Brandáriz, Jessica Pérez, Yolanda Rodríguez, Damián García-Olmo, Rogelio González-Sarmiento, Miguel Urioste, José Perea
No abstract text is available yet for this article.
February 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29373110/gorlin-syndrome
#7
I Palacios-Álvarez, R González-Sarmiento, E Fernández-López
Gorlin syndrome is a rare autosomal dominant disease caused by mutations in the sonic hedgehog signaling pathway. Of particular importance is the PTCH1 gene. The disease is characterized by the development of multiple basal cell carcinomas at young ages. These tumors may present with other skin manifestations such as palmoplantar pits and with extracutaneous manifestations such as odontogenic keratocysts and medulloblastoma. Although the dermatologist may be key for recognizing clinical suspicion of the syndrome, a multidisciplinary team is usually necessary for diagnosis, treatment, and follow-up...
April 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29275168/molecular-analysis-of-thyroglobulin-mutations-found-in-patients-with-goiter-and-hypothyroidism
#8
Sofia Siffo, Ezequiela Adrover, Cintia E Citterio, Mirta B Miras, Viviana A Balbi, Ana Chiesa, Jacques Weill, Gabriela Sobrero, Verónica G González, Patricia Papendieck, Elena Bueno Martinez, Rogelio Gonzalez-Sarmiento, Carina M Rivolta, Héctor M Targovnik
Thyroid dyshormonogenesis due to thyroglobulin (TG) gene mutations have an estimated incidence of approximately 1 in 100,000 newborns. The clinical spectrum ranges from euthyroid to mild or severe hypothyroidism. Up to now, one hundred seventeen deleterious mutations in the TG gene have been identified and characterized. The purpose of the present study was to identify and characterize new mutations in the TG gene. We report eight patients from seven unrelated families with goiter, hypothyroidism and low levels of serum TG...
December 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29233635/therapeutic-benefit-of-environmental-enrichment-on-optic-neuritis
#9
Marcos L Aranda, María F González Fleitas, Hernán H Dieguez, Georgia A Milne, Julián D Devouassoux, María I Keller Sarmiento, Mónica Chianelli, Pablo H Sande, Damián Dorfman, Ruth E Rosenstein
Optic neuritis (ON) is an inflammatory, demyelinating, neurodegenerative, and presently untreatable condition of the optic nerve which might induce blindness. We analyzed the effect of environmental enrichment (EE) on visual pathway damage provoked by experimental ON induced by a microinjection of bacterial lipopolysaccharide (LPS) into the optic nerve. For this purpose, LPS was microinjected into the optic nerve from male Wistar rats. After injection, one group of animals was submitted to EE, and another group remained in standard environment (SE) for 21 days...
December 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29214116/compassionate-use-of-ruxolitinib-in-acute-and-chronic-graft-versus-host-disease-refractory-both-to-corticosteroids-and-extracorporeal-photopheresis
#10
Mauricio Sarmiento Maldonado, Pablo Ramírez Villanueva, Pablo Bertín Cortes-Monroy, Veronica Jara Arias, Katherine Soto Donoso, Pablo Uribe Gonzalez, Mauricio Ocqueteau Tachini, Jose Antonio Perez-Simón
Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation: In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29170203/identification-of-a-novel-locus-on-chromosome-2q13-which-predisposes-to-clinical-vertebral-fractures-independently-of-bone-density
#11
Nerea Alonso, Karol Estrada, Omar M E Albagha, Lizbeth Herrera, Sjur Reppe, Ole K Olstad, Kaare M Gautvik, Niamh M Ryan, Kathryn L Evans, Carrie M Nielson, Yi-Hsiang Hsu, Douglas P Kiel, George Markozannes, Evangelia E Ntzani, Evangelos Evangelou, Bjarke Feenstra, Xueping Liu, Mads Melbye, Laura Masi, Maria Luisa Brandi, Philip Riches, Anna Daroszewska, José Manuel Olmos, Carmen Valero, Jesús Castillo, José A Riancho, Lise B Husted, Bente L Langdahl, Matthew A Brown, Emma L Duncan, Stephen Kaptoge, Kay-Tee Khaw, Ricardo Usategui-Martín, Javier Del Pino-Montes, Rogelio González-Sarmiento, Joshua R Lewis, Richard L Prince, Patrizia D'Amelio, Natalia García-Giralt, Xavier Nogués, Simona Mencej-Bedrac, Janja Marc, Orit Wolstein, John A Eisman, Ling Oei, Carolina Medina-Gómez, Katharina E Schraut, Pau Navarro, James F Wilson, Gail Davies, John Starr, Ian Deary, Toshiko Tanaka, Luigi Ferrucci, Fernando Gianfrancesco, Luigi Gennari, Gavin Lucas, Roberto Elosua, André G Uitterlinden, Fernando Rivadeneira, Stuart H Ralston
OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression quantitative trait loci (eQTL) data from transiliac bone biopsies and bioinformatic studies...
March 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29066246/changes-on-serum-and-hepatic-lipidome-after-a-chronic-cadmium-exposure-in-wistar-rats
#12
Victor Enrique Sarmiento-Ortega, Samuel Treviño, José Ángel Flores-Hernández, Patricia Aguilar-Alonso, Diana Moroni-González, Violeta Aburto-Luna, Alfonso Diaz, Eduardo Brambila
No abstract text is available yet for this article.
December 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29045705/outbreak-and-eradication-of-tropical-rat-mite-acari-macronyssidae-in-a-european-animal-facility
#13
Yeray Brito-Casillas, Mercedes Díaz-Sarmiento, Moisés García-Arencibia, Cristina Carranza, Antonio Castrillo, Leandro Fernández-Pérez, Manuel Zumbado-Peña, Jorge F González, Ana M Wägner
A zoonotic, opportunistic out-break of tropical rat mite Ornithonyssus bacoti [Acari: Macronyssidae; Ornithonyssus bacoti (Hirst)] in an animal facility, is described. Immunocompetent mice [Mus musculus (Linnaeus)] and rat [Rattus norvegicus (Berkenhout)] strains in a conventional health status facility suffered from scratching and allopecia and staff members suffered from pruritic, erythemato-papular lesions, presumed to be allergic in origin. O. bacoti was identified and treatment with a 0.1% ivermectin solution led to its complete erradication...
February 28, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28971901/molecular-and-clinical-profile-of-von-willebrand-disease-in-spain-pcm-evw-es-comprehensive-genetic-analysis-by-next-generation-sequencing-of-480-patients
#14
Nina Borràs, Javier Batlle, Almudena Pérez-Rodríguez, María Fernanda López-Fernández, Ángela Rodríguez-Trillo, Esther Lourés, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, Rafael Parra, María Eva Mingot-Castellano, Ignacia Balda, Carme Altisent, Rocío Pérez-Montes, Rosa María Fisac, Gemma Iruín, Sonia Herrero, Inmaculada Soto, Beatriz de Rueda, Víctor Jiménez-Yuste, Nieves Alonso, Dolores Vilariño, Olga Arija, Rosa Campos, María José Paloma, Nuria Bermejo, Rubén Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Lizheidy Sarmiento, Belén Iñigo, María Del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Jesús María César, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Rosa Cornudella, Carlos Aguilar, Francisco Vidal, Irene Corrales
Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses. The need for molecular and clinical characterization of von Willebrand disease in Spain prompted the creation of a multicenter project (PCM-EVW-ES) that resulted in the largest prospective cohort study of patients with all types of von Willebrand disease. Molecular analysis of relevant regions of the VWF , including intronic and promoter regions, was achieved in the 556 individuals recruited via the development of a simple, innovative, relatively low-cost protocol based on microfluidic technology and next-generation sequencing...
December 2017: Haematologica
https://www.readbyqxmd.com/read/28966800/parity-history-determines-a-systemic-inflammatory-response-to-spread-of-ovarian-cancer-in-naturally-aged-mice
#15
Ulises Urzua, Carlos Chacon, Luis Lizama, Sebastián Sarmiento, Pía Villalobos, Belén Kroxato, Katherine Marcelain, María-Julieta Gonzalez
Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and parity on the systemic inflammation markers that are particularly relevant to OC initiation and progression at menopause remain largely unknown. Herein, we profiled a panel of circulating cytokines in multiparous versus virgin C57BL/6 female mice at peri-estropausal age and investigated how cytokine levels were modulated by intraperitoneal tumor induction in a syngeneic immunocompetent OC mouse model...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28761177/analysis-of-autophagy-gene-polymorphisms-in-spanish-patients-with-head-and-neck-squamous-cell-carcinoma
#16
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira Del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733979/novel-clinical-and-molecular-findings-in-spanish-patients-with-naevoid-basal-cell-carcinoma-syndrome
#17
N Alonso, J Cañueto, S Ciria, E Bueno, I Palacios-Alvarez, M Alegre, C Badenas, A Barreiro, L Pena, C Maldonado, M V Nespeira-Jato, C Peña-Penabad, A Azon, M Gavrilova, I Ferrer, O Sanmartin, L Robles, A Hernandez-Martin, M Urioste, S Puig, L Puig, R Gonzalez-Sarmiento
BACKGROUND: Naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental alterations and multiple basal cell carcinomas. Mutations in PTCH1, which encodes a membrane receptor for Sonic Hedgehog, are associated with the development of the disease. Most of them produce a truncated protein, which is unable to suppress Smoothened protein and continuously activates the downstream pathway. OBJECTIVES: We aimed to characterize 22 unrelated Spanish patients with NBCCS, the largest cohort with Gorlin syndrome reported to date in Spain...
January 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/28627087/familial-seborrhoeic-keratosis-associated-with-multiple-pure-reticulated-acanthomas-and-infundibulocystic-basal-cell-carcinomas
#18
J Agustí Martínez, R Bella-Navarro, A B García-García, E Bueno, R González-Sarmiento, L Navarro, B Sanchez-Sendra, A Revert, E Jordá, C Monteagudo
BACKGROUND: A variety of genodermatoses with multiple cutaneous tumours and germline genetic alterations, such as PTCH1 mutations, have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis. OBJECTIVES: To describe the clinical, dermoscopic and histopathological features of multiple cutaneous lesions, mostly infundibulocystic basal cell carcinomas (ICBCCs) and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis...
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28614433/diagnostic-labels-of-nanda-i-in-a-southern-region-of-spain
#19
Rafael González-Rodríguez, María de Los Ángeles Martelo-Baro, Pilar Bas-Sarmiento
Objective: to determine the incidence of NANDA-I diagnostic labels (North American Nursing Diagnosis Association-International) and to establish the distribution of cases of assistance and the associated labels, according to sociodemographic variables (age and sex). Method: descriptive, cross-sectional epidemiological study of labels of NANDA-I, under ecological design. The distribution of labels was analyzed according to sex and age; the corresponding frequencies were calculated and for each label the incidence were calculated rates with aggregate data from the attended cases...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28609280/the-history-behind-successful-uterine-transplantation-in-humans
#20
Luis Arturo Ruvalcaba Castellón, Martha Isolina García Amador, Roberto Enrique Díaz González, Montoya Sarmiento Jorge Eduardo, César Díaz-García, Niclas Kvarnström, Mats Bränström
This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003...
June 1, 2017: JBRA Assisted Reproduction
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