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https://www.readbyqxmd.com/read/29678062/taking-into-account-the-complementarity-of-contemporary-breast-cancer-guidelines-to-leverage-decision-support-in-the-desiree-project
#1
Coralie Prebet, Jacques Bouaud, Gilles Guézennec, Brigitte Seroussi
Breast cancer is one of the most common cancers in Western countries and the first cause of death among women in France. Studies have reported that the compliance of the treatment with breast cancer clinical practice guidelines (CPGs) is accompanied with a significant improvement of recurrence-free survival and overall survival rates. However, compliance of multidisciplinary tumour board decisions with CPGs remains non-satisfactory. The European project DESIREE aims at building a software package to support the guideline-based management of breast cancer patients...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29663686/-68-ga-psma-pet-ct-staging-prior-to-definitive-radiation-treatment-for-prostate-cancer
#2
George Hruby, Thomas Eade, Louise Emmett, Bao Ho, Ed Hsiao, Geoff Schembri, Linxin Guo, Carolyn Kwong, Julia Hunter, Keelan Byrne, Andrew Kneebone
AIM: To explore the utility of prostate specific membrane antigen (PSMA)-positron emission tomography (PET)/computed tomography (CT) in addition to conventional imaging prior to definitive external beam radiation treatment (EBRT) for prostate cancer. METHODS: All men undergoing PSMA-PET/CT prior to definitive EBRT for intermediate and high-risk prostate cancer were included in our ethics approved prospective database. For each patient, clinical and pathological results, in addition to scan results including site of PSMA positive disease and number of lesions, were recorded...
April 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29655620/identification-of-men-with-low-risk-biopsy-confirmed-prostate-cancer-as-candidates-for-active-surveillance
#3
Daniel W Lin, E David Crawford, Thomas Keane, Brent Evans, Julia Reid, Saradha Rajamani, Krystal Brown, Alexander Gutin, Jonathan Tward, Peter Scardino, Michael Brawer, Steven Stone, Jack Cuzick
BACKGROUND: A combined clinical cell-cycle risk (CCR) score that incorporates prognostic molecular and clinical information has been recently developed and validated to improve prostate cancer mortality (PCM) risk stratification over clinical features alone. As clinical features are currently used to select men for active surveillance (AS), we developed and validated a CCR score threshold to improve the identification of men with low-risk disease who are appropriate for AS. METHODS: The score threshold was selected based on the 90th percentile of CCR scores among men who might typically be considered for AS based on NCCN low/favorable-intermediate risk criteria (CCR = 0...
April 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29629801/modified-national-comprehensive-cancer-network-criteria-for-assessing-resectability-of-pancreatic-ductal-adenocarcinoma
#4
Yoshifumi Noda, Satoshi Goshima, Hiroshi Kawada, Nobuyuki Kawai, Toshiharu Miyoshi, Masayuki Matsuo, Kyongtae T Bae
OBJECTIVE: The objective of our study was to assess the preoperative resectability of pancreatic ductal adenocarcinoma (PDAC) using the National Comprehensive Cancer Network (NCCN) guideline, the general rules of the Japan Pancreas Society (JPS), and both of them combined. MATERIALS AND METHODS: Eighty-six consecutive patients with PDAC (50 men and 36 women; mean age ± SD, 70.8 ± 9.0 years; age range, 49-86 years) underwent dynamic contrast-enhanced CT. Following the NCCN guideline, the degree of vascular invasion was evaluated to determine the NCCN score: 0 points for absence of vascular invasion, 1 point for tumor contact ≤ 180°, and 2 points for tumor contact > 180°...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29625782/lymph-node-yield-during-radical-prostatectomy-does-not-impact-rate-of-biochemical-recurrence-in-patients-with-seminal-vesicle-invasion-and-node-negative-disease
#5
Ketan K Badani, Balaji N Reddy, Eric J Moskowitz, David J Paulucci, Alp Tuna Beksac, Alberto Martini, Michael J Whalen, Douglas W Skarecky, Linda My Huynh, Thomas E Ahlering
OBJECTIVES: Seminal vesicle invasion (SVI) is a risk factor for poor oncologic outcome in patients with prostate cancer. Modifications to the pelvic lymph node dissection (PLND) during radical prostatectomy (RP) have been reported to have a therapeutic benefit. The present study is the first to determine if lymph node yield (LNY) is associated with a lower risk of biochemical recurrence (BCR) for men with SVI. METHODS: A total of 220 patients from 2 high-volume institutions who underwent RP without adjuvant treatment between 1990 and 2015 and had prostate cancer with SVI (i...
April 3, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29607601/ldr-brachytherapy-for-the-treatment-of-localised-prostate-cancer-in-men-with-a-high-risk-of-disease-relapse
#6
Robert Laing, Jennifer Uribe, Santiago Uribe-Lewis, Julian Money-Kyrle, Carla Perna, Stylianos Chintzoglou, Sara Khaksar, Stephen E M Langley
OBJECTIVES: To report clinical outcomes of Iodine-125 Low-Dose-Rate Prostate Brachytherapy (LDR-PB) as monotherapy or in combination with androgen deprivation therapy (ADT) and/or external beam radiotherapy (EBRT) in high-risk localised prostate cancer (PCa). PATIENTS AND METHODS: Analysis of clinical outcomes from a prospective cohort of patients treated with LDR-PB alone or combination treatment in a single institution. Men with a high risk of disease relapse were identified by the National Institute for Healthcare Excellence (NICE) criteria or by the National Comprehensive Cancer Network (NCCN) criteria...
April 1, 2018: BJU International
https://www.readbyqxmd.com/read/29605260/pediatric-phyllodes-tumors-a-review-of-the-national-cancer-data-base-and-adherence-to-nccn-guidelines-for-phyllodes-tumor-treatment
#7
Harold J Leraas, Laura H Rosenberger, Yi Ren, Brian Ezekian, Uttara P Nag, Christopher R Reed, Samantha M Thomas, Eun-Sil Shelley Hwang, Elisabeth T Tracy
BACKGROUND: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, few large pediatric phyllodes tumor series exist. Current guidelines do not differentiate treatment recommendations between children and adults. We examined national guideline adherence for children and adults. METHODS: We queried the NCDB (2004-2014) for female patients with phyllodes tumor histology, excluding patients with missing age or survival data...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29599926/role-of-cooperative-groups-and-funding-source-in-clinical-trials-supporting-guidelines-for-systemic-therapy-of-breast-cancer
#8
Ariadna Tibau, Geòrgia Anguera, Fernando Andrés-Pretel, Arnoud J Templeton, Bostjan Seruga, Agustí Barnadas, Eitan Amir, Alberto Ocana
Introduction: Clinical research is conducted by academia, cooperative groups (CGs) or pharmaceutical industry. Here, we evaluate the role of CGs and funding sources in the development of guidelines for breast cancer therapies. Results: We identified 94 studies. CGs were involved in 28 (30%) studies while industry either partially or fully sponsored 64 (68%) studies. The number of industry funded studies increased over time (from 0% in 1976 to 100% in 2014; p for trend = 0...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29595634/targeted-agents-for-patients-with-advanced-metastatic-pancreatic-cancer-a-protocol-for-systematic-review-and-network-meta-analysis
#9
Baoshan Di, Bei Pan, Long Ge, Jichun Ma, Yiting Wu, Tiankang Guo
BACKGROUND: Pancreatic cancer (PC) is a devastating malignant tumor. Although surgical resection may offer a good prognosis and prolong survival, approximately 80% patients with PC are always diagnosed as unresectable tumor. National Comprehensive Cancer Network's (NCCN) recommended gemcitabine-based chemotherapy as efficient treatment. While, according to recent studies, targeted agents might be a better available option for advanced or metastatic pancreatic cancer patients. The aim of this systematic review and network meta-analysis will be to examine the differences of different targeted interventions for advanced/metastatic PC patients...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594362/single-institution-experience-with-gemcitabine-cisplatin-combination-therapy-as-a-second-line-treatment-for-patients-with-unresectable-biliary-tract-cancer-after-failure-of-gemcitabine-s-1-combination-therapy-a-prospective-feasibility-study
#10
Ryusei Matsuyama, Daisuke Morioka, Ryutaro Mori, Seigo Hiratani, Yasuhiro Yabushita, Yohei Ota, Takafumi Kumamoto, Koichi Taniguchi, Itaru Endo
BACKGROUND: NCCN and Japanese clinical guidelines for the treatment of biliary tract cancer (BTC) addressed gemcitabine-cisplatin combination (GC) as first-line chemotherapy for patients with advanced BTC ineligible for surgery in 2013. However, gemcitabine-S1 combination therapy (GS) has been widely used as first-line treatment in Japan because Japanese social insurance coverage of S-1 for BTC was approved prior to that of cisplatin. AIM: To elucidate the efficacy and tolerability of GC as second-line chemotherapy for patients with unresectable BTC after failure of GS...
March 28, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29589223/an-analysis-of-the-inclusion-of-medications-considered-potentially-inappropriate-in-older-adults-in-chemotherapy-templates-for-hematologic-malignancies-one-recommendation-for-all
#11
Amy Zhou, Holly M Holmes, Arti Hurria, Tanya M Wildes
BACKGROUND: There remains a paucity of data regarding the use of potentially inappropriate medications (PIMs) in the supportive management of older adults undergoing chemotherapy. Raising awareness among healthcare providers regarding the frequency of their use and potential toxicities may help to minimize the risks to patients. OBJECTIVE: The aim of this study was to evaluate the frequency of six specific classes of medications considered PIMs by the American Geriatrics Society Beers Criteria that are commonly included in the National Comprehensive Cancer Network (NCCN) chemotherapy order templates for hematologic malignancies...
March 27, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29589051/-chemotherapy-induced-nausea-and-vomiting-current-recommendations-for-prophylaxis
#12
REVIEW
E Storz, J E Gschwend, M Retz
The chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent side effects in cytostatic therapy and a profound challenge during the therapy of cancer patients. Therefore, standardized guideline-orientated prophylaxis is essential and a fundamental contribution for the success of treatment. This review summarizes the current recommendations for CINV of the Multinational Association of Supportive Care in Cancer (MASCC) and European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the S3-guideline Supportive Therapie of the Leitlinienprogramm Onkologie and shall facilitate its use in the daily routine...
March 27, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29587931/-management-strategies-of-pulmonary-ground-galss-nodule
#13
Qun Wang
Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. The management for pulmonary GGN remains controversial. Both Fleischner society and National Comprehensive Cancer Network (NCCN) panel updated the guideline for the management of GGN in 2017. Compared with previous versions, the indication for surgery or biopsy is stricter, and the recommended follow-up interval is prolonged. In clinical practice, the size of GGN component, the size of consolidation component, dynamic change during follow-up and computed tomography (CT) value are the four factors that help surgeons to decide the timing of surgery...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29574395/acute-myeloid-leukemia-induction-with-cladribine-outcomes-by-age-and-leukemia-risk
#14
Martin W Schoen, Susan K Woelich, James T Braun, Dhinesh V Reddy, Mark J Fesler, Paul J Petruska, Carl E Freter, Jack M Lionberger
Acute myeloid leukemia (AML) induction traditionally includes seven days of cytarabine and three days of an anthracycline (7 + 3). Because of evidence of increased efficacy of cladribine combined with this regimen, we conducted a retrospective analysis of 107 AML patients treated with idarubicin, cytarabine and cladribine (IAC) at our institution. Complete remission (CR) occurred in 71%, with overall response of 79%. One-year survival overall was 59%, with 47% (27/57) among patients ≥60 years old and 72% (36/50) in those <60 (Relative Risk [RR] 1...
March 6, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29571936/early-results-of-extreme-hypofractionation-using-stereotactic-body-radiation-therapy-for-high-risk-very-high-risk-and-node-positive-prostate-cancer
#15
V Murthy, M Gupta, G Mulye, S Maulik, M Munshi, R Krishnatry, R Phurailatpam, R Mhatre, G Prakash, G Bakshi
AIMS: Stereotactic body radiotherapy (SBRT) in low- and intermediate-risk prostate cancer has shown encouraging results. However, its use in high-risk patients is limited due to lack of data regarding adequate radiotherapy dose, need for pelvic nodal treatment and androgen deprivation therapy. Herein we report our experience of SBRT in this subgroup. MATERIALS AND METHODS: Analysis of a prospectively maintained database of 68 consecutive patients of the National Comprehensive Cancer Network (NCCN) high-risk, very high-risk and node-positive adenocarcinoma prostate treated with SBRT was undertaken...
March 20, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29569018/breast-cancer-survival-survival-disparities-and-guideline-based-treatment
#16
Deirdre A Hill, Sarah Friend, Lesley Lomo, Charles Wiggins, Marc Barry, Eric Prossnitz, Melanie Royce
PURPOSE: The role of appropriate therapy in breast cancer survival and survival disparities by race/ethnicity has not been fully elucidated. We investigated whether lack of guideline-recommended therapy contributed to survival differences overall and among Hispanics relative to non-Hispanic white (NHW) women in a case-cohort study. METHODS: The study included a 15% random sample of female invasive breast cancer patients diagnosed from 1997 to 2009 in 6 New Mexico counties and all deaths due to breast cancer-related causes...
March 22, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29566109/adoption-of-total-neoadjuvant-therapy-for-locally-advanced-rectal-cancer
#17
Andrea Cercek, Campbell S D Roxburgh, Paul Strombom, J Joshua Smith, Larissa K F Temple, Garrett M Nash, Jose G Guillem, Philip B Paty, Rona Yaeger, Zsofia K Stadler, Kenneth Seier, Mithat Gonen, Neil H Segal, Diane L Reidy, Anna Varghese, Jinru Shia, Efsevia Vakiani, Abraham J Wu, Christopher H Crane, Marc J Gollub, Julio Garcia-Aguilar, Leonard B Saltz, Martin R Weiser
Importance: Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been developed to optimize delivery of effective systemic therapy aimed at micrometastases. Objective: To compare the traditional approach of preoperative chemoradiation (chemoRT) followed by postoperative adjuvant chemotherapy with the more recent TNT approach for LARC...
March 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29553001/risk-of-surgical-site-infection-ssi-following-colorectal-resection-is-higher-in-patients-with-disseminated-cancer-an-nccn-member-cohort-study
#18
Mini Kamboj, Teresa Childers, Jessica Sugalski, Donna Antonelli, Juliane Bingener-Casey, Jamie Cannon, Karie Cluff, Kimberly A Davis, E Patchen Dellinger, Sean C Dowdy, Kim Duncan, Julie Fedderson, Robert Glasgow, Bruce Hall, Marilyn Hirsch, Matthew Hutter, Lisa Kimbro, Boris Kuvshinoff, Martin Makary, Melanie Morris, Sharon Nehring, Sonia Ramamoorthy, Rebekah Scott, Mindy Sovel, Vivian Strong, Ashley Webster, Elizabeth Wick, Julio Garcia Aguilar, Robert Carlson, Kent Sepkowitz
BACKGROUND Surgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement. OBJECTIVE To examine rates of SSI in patients with and without cancer and to identify potential predictors of SSI risk following CRS DESIGN American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data files for 2011-2013 from a sample of 12 National Comprehensive Cancer Network (NCCN) member institutions were combined...
March 19, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29551548/effects-of-perineural-invasion-on-biochemical-recurrence-and-prostate-cancer-specific-survival-in-patients-treated-with-definitive-external-beam-radiotherapy
#19
Luke C Peng, Amol K Narang, Carol Gergis, Noura A Radwan, Peijin Han, Ariel E Marciscano, Scott P Robertson, Pei He, Janson Trieu, Ashwin N Ram, Todd R McNutt, Emily Griffith, Theodore A DeWeese, Stephanie Honig, Harleen Singh, Stephen C Greco, Phuoc T Tran, Curtiland Deville, Theodore L DeWeese, Daniel Y Song
OBJECTIVES: Perineural invasion (PNI) has not yet gained universal acceptance as an independent predictor of adverse outcomes for prostate cancer treated with external beam radiotherapy (EBRT). We analyzed the prognostic influence of PNI for a large institutional cohort of prostate cancer patients who underwent EBRT with and without androgen deprivation therapy (ADT). MATERIAL AND METHODS: We, retrospectively, reviewed prostate cancer patients treated with EBRT from 1993 to 2007 at our institution...
March 15, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29545726/germline-mutations-in-hereditary-diffuse-gastric-cancer
#20
Hao Zhang, Mengmeng Feng, Yi Feng, Zhaode Bu, Ziyu Li, Shuqin Jia, Jiafu Ji
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Among which, about 1%-3% of gastric cancer patients were characterized by inherited gastric cancer predisposition syndromes, knowing as hereditary diffuse gastric cancer (HDGC). Studies reported that CDH1 germline mutations are the main cause of HDGC. With the help of rapid development of genetic testing technologies and data analysis tools, more and more researchers focus on seeking candidate susceptibility genes for hereditary cancer syndromes...
February 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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