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https://www.readbyqxmd.com/read/28926209/on-the-nature-of-isomeric-nonfluorescent-chlorophyll-catabolites-in-leaves-and-fruit-a-study-with-a-ubiquitous-phylloleucobilin-and-its-main-isomerization-product
#1
Simone Moser, Gerhard Scherzer, Bernhard Kräutler
The typical main products of chlorophyll (Chl) breakdown in higher plants are non-fluorescent, colorless phyllobilins, named phylloleucobilins. These long elusive Chl-catabolites are linear tetrapyrroles, whose structure elucidation has required thorough spectroscopic analyses. Interestingly, in recent LC/MS studies of leaf extracts, isomeric forms of phylloleucobilins were detected. The existence of isomeric phyllobilins may suggest incomplete stereo-selectivity of catabolic processes, or isomerization processes in plant cells or in the analytes...
September 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28919490/alcohol-exposure-induces-chick-craniofacial-bone-defects-by-negatively-affecting-cranial-neural-crest-development
#2
Ping Zhang, Guang Wang, Zhuangling Lin, Yushi Wu, Jing Zhang, Meng Liu, Kenneth Ka Ho Lee, Manli Chuai, Xuesong Yang
Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus...
September 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28919310/cadherin-11-promotes-neural-crest-cell-spreading-by-reducing-intracellular-tension-mapping-adhesion-and-mechanics-in-neural-crest-explants-by-atomic-force-microscopy
#3
REVIEW
Carina Blaue, Jubin Kashef, Clemens M Franz
During development cranial neural crest cells (NCCs) display a striking transition from collective to single-cell migration, but the mechanisms enabling individual NCCs to separate from the neural crest tissue are still incompletely understood. In this study we have employed atomic force microscopy (AFM) to investigate potential adhesive and mechanical changes associated with the dissociation of individual cells from cohesive Xenopus NCC explants at early stages of migration. AFM-based single-cell force spectroscopy (SCFS) revealed a uniform distribution of cell-cell adhesion forces within NCC explants, including semi-detached leader cells in the process of delaminating from the explant edge...
September 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28917920/one-step-hydrothermal-synthesis-of-fluorescent-nanocrystalline-cellulose-carbon-dot-hydrogels
#4
Wei Li, Sichun Wang, Ying Li, Chunhui Ma, Zhanhua Huang, Chunsheng Wang, Jian Li, Zhijun Chen, Shouxin Liu
Fluorescent nanocrystalline cellulose/carbon dots (NCC/CDs) hydrogels were successfully prepared by a facile one-step green hydrothermal carbonization process. The properties of NCC/CDs hydrogels prepared at different temperatures were investigated by fluorescence spectroscopy, transmission electron microscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction, and thermogravimetric analysis. NCC/CDs hydrogels with high crystallinity, high thermal stability, and excellent fluorescence properties can be obtained by controlling the hydrothermal treatment temperature...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917867/nanocrystalline-cellulose-isolated-from-discarded-cigarette-filters
#5
Segun A Ogundare, Vashen Moodley, Werner E van Zyl
We report the isolation of nanocrystalline cellulose (NCC) produced from discarded cigarette filters (DCF). The DCF were processed into cellulose via ethanolic extraction, hypochlorite bleaching, alkaline deacetylation, and then converted into NCC by sulfuric acid hydrolysis. The morphological structures of the isolated NCC established with TEM showed that the nanocrystals were needle-like with a mean length of 143nm. FEGSEM showed the morphological transition of the micro-sized DCF to self-assembled NCC while EDX revealed the presence of Ti (as TiO2) in DCF, which was retained in the NCC...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28910094/hemicellulosic-polysaccharides-mimics-synthesis-of-tailored-bottlebrush-like-xyloglucan-oligosaccharide-glycopolymers-as-binders-of-nanocrystalline-cellulose
#6
Jing Chen, Christophe Travelet, Redouane Borsali, Sami Halila
We report in this contribution that while low molecular weight hemicellulosic building blocks are known not to interact with cellulosic materials, their multivalent presentation on a polymeric scaffold significantly enhanced the binding interactions that are remarkably in the same range as those usually observed for lectin-carbohydrate interactions. We developed a poly(propargyl methacrylate) scaffold on which we conjugated, by "post-click" reaction, a variety of azide reducing-end functionalized xyloglucan oligosaccharides with controlled enzymatic-mediated rate of degalactosylation...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28898419/a-block-matching-based-approach-with-multiple-simultaneous-templates-for-the-real-time-2d-ultrasound-tracking-of-liver-vessels
#7
Andrew J Shepard, Bo Wang, Thomas K F Foo, Bryan P Bednarz
PURPOSE: The implementation of motion management techniques in radiation therapy can aid in mitigating uncertainties and reducing margins. For motion management to be effective, it is necessary to track key structures both accurately and at a real-time speed. Therefore, the focus of this work was to develop a 2D algorithm for the real-time tracking of ultrasound features to aid in radiation therapy motion management. MATERIALS AND METHODS: The developed algorithm utilized a similarity measure-based block matching algorithm incorporating training methods and multiple simultaneous templates...
September 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28882721/clinical-presentation-of-neurocysticercosis-related-epilepsy
#8
REVIEW
Kevin R Duque, Jorge G Burneo
Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system and a major risk factor for seizures and epilepsy. Seizure types in NCC vary largely across studies and seizure semiology is poorly understood. We discuss here the studies regarding seizure types and seizure semiology in NCC, and examine the clinical presentation in patients with NCC and drug-resistant epilepsy. We also provide evidence of the role of MRI and EEG in the diagnosis of NCC-related epilepsy. Focal seizures are reported in 60-90% of patients with NCC-related epilepsy, and around 90% of all seizures registered prospectively are focal not evolving to bilateral tonic-clonic seizures...
September 4, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28882404/health-related-quality-of-life-following-radical-cystectomy-comparative-analysis-from-the-medicare-health-outcomes-study
#9
Brian R Winters, Jonathan L Wright, Sarah K Holt, Atreya Dash, John L Gore, George R Schade
PURPOSE: Health related quality of life (HRQOL) after radical cystectomy (RC) and ileal conduit is not well quantified at the population level. We evaluated HRQOL in patients with bladder cancer (BC) compared with non-cancer controls (NCC) and colorectal cancer (CRC) patients using SEER-Medicare Health Outcomes Survey (MHOS) data. MATERIALS AND METHODS: SEER-MHOS data (1998-2013) was used to identify patients with BC and CRC undergoing extirpative surgery with ileal conduit or colostomy creation...
September 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28877879/uninephrectomy-and-apical-fluid-shear-stress-decrease-enac-abundance-in-collecting-duct-principal-cells
#10
Thomas Ernandez, Khalil Udwan, Alexandra Chassot, Pierre-Yves Martin, Eric Feraille
Acute nephron reduction such as after living kidney donation may increase the risk of hypertension. Uninephrectomy induces major hemodynamic changes in the remaining kidney resulting in rapid increase of single nephron GFR and fluid delivery in the distal nephron. Decreased sodium (Na) fractional reabsorption after the distal tubule has been reported after uninephrectomy in animals preserving volume homeostasis. In the present study, we thought to specifically explore the effect of unilateral nephrectomy on ENaC subunits expression in mice...
September 6, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28877076/disruption-of-the-with-no-lysine-kinase-ste20-proline-alanine-rich-kinase-pathway-reduces-the-hypertension-induced-by-angiotensin-ii
#11
Luz G Cervantes-Perez, Maria Castaneda-Bueno, Jose V Jimenez, Norma Vazquez, Lorena Rojas-Vega, Dario R Alessi, Norma A Bobadilla, Gerardo Gamba
OBJECTIVE: The hypertensive effect of angiotensin II (AngII), a peptide hormone, is dependent on its intrarenal actions and the activation of the renal Na-Cl cotransporter (NCC), by AngII requires integrity of the with no lysine kinase/STE20-proline alanine-rich kinase (WNK/SPAK) signaling pathway. Here, we analyzed if the integrity of the WNK/SPAK pathway is required for AngII infusion to induce arterial hypertension. METHODS: We tested the effect of AngII or aldosterone administration on the blood pressure and on pNCC/NCC ratio in SPAK knock-in mice in which the kinase and thus NCC cannot be activated by WNK kinases...
September 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28870047/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-gitelman-syndrome
#12
(no author information available yet)
Gitelman syndrome (GS) is an autosomal recessive, salt-losing tubulopathy caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is characterized by hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. GS is one of the most common inherited renal tubulopathy with a prevalence estimated at about one to ten per 40 000 people. The prevalence of GS is even higher in Asia than other countries. The majority of GS patients present mild and nonspecific symptoms during adolescence or adulthood...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28855510/mining-novel-starch-converting-glycoside-hydrolase-70-enzymes-from-the-nestl%C3%A3-culture-collection-genome-database-the-lactobacillus-reuteri-ncc-2613-gtfb
#13
Joana Gangoiti, Sander S van Leeuwen, Xiangfeng Meng, Stéphane Duboux, Christina Vafiadi, Tjaard Pijning, Lubbert Dijkhuizen
The Glycoside hydrolase (GH) family 70 originally was established for glucansucrases of lactic acid bacteria (LAB) converting sucrose into α-glucan polymers. In recent years we have identified 3 subfamilies of GH70 enzymes (designated GtfB, GtfC and GtfD) as 4,6-α-glucanotransferases, cleaving (α1 → 4)-linkages in maltodextrins/starch and synthesizing new (α1 → 6)-linkages. In this work, 106 putative GtfBs were identified in the Nestlé Culture Collection genome database with ~2700 genomes, and the L...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840072/treatment-of-racemose-neurocysticercosis
#14
Samuel G McClugage, Rachael A Lee, Bernard C Camins, Juan J Mercado-Acosta, Martin Rodriguez, Kristen O Riley
BACKGROUND: Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system, caused by the tapeworm Taenia solium. It is endemic to certain parts of the world, including Central America, South America, Asia, and Africa. The racemose form, characterized by extraparenchymal location, increased morbidity and mortality, and large loculated cystic lesions, is rarely seen in industrialized countries, such as the United States. The management of racemose neurocysticercosis (RNCC) differs from that of the typical parenchymal variant...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28838876/ventriculoscopic-approach-for-intraventricular-neurocysticercosis-a-single-neurosurgical-center-s-experience
#15
Li Zhenye, Li Chuzhong, Zong Xuyi, Gui Songbai, Zhao Peng, Bai Jiwei, Cao Lei, Wang Xinsheng
OBJECT: The object of this study was to retrospectively analyze the patients with intraventricular neurocysticercosis (NCC) who underwent ventriculoscopic approach at a single neurosurgical center, and assessed the efficacy of this treatment in patients with intraventricular NCC. METHODS: Intraventricular NCC patients who underwent ventriculoscopic approach between January 2008 and March 2014 at Beijing Tiantan Hospital were analyzed. RESULTS: A total of 21 intraventricular NCC patients, including 15 men and 6 women were enrolled in the study (38...
August 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28838172/national-regional-and-global-certification-bodies-for-polio-eradication-a-framework-for-verifying-measles-elimination
#16
S Deblina Datta, Rudolf H Tangermann, Susan Reef, W William Schluter, Anthony Adams
The Global Certification Commission (GCC), Regional Certification Commissions (RCCs), and National Certification Committees (NCCs) provide a framework of independent bodies to assist the Global Polio Eradication Initiative (GPEI) in certifying and maintaining polio eradication in a standardized, ongoing, and credible manner. Their members meet regularly to comprehensively review population immunity, surveillance, laboratory, and other data to assess polio status in the country (NCC), World Health Organization (WHO) region (RCC), or globally (GCC)...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28836363/improving-pharmacotherapy-outcomes-in-patients-with-hepatitis-c-virus-infection-treated-with-direct-acting-antivirals-the-gruvic-project
#17
Esther Chamorro-de-Vega, Carmen Guadalupe Rodriguez-Gonzalez, Alvaro Gimenez-Manzorro, Ana de Lorenzo-Pinto, Irene Iglesias-Peinado, Ana Herranz, Maria Sanjurjo
BACKGROUND/OBJECTIVE: Pharmaceutical care is needed in hepatitis C virus (HCV)-infected patients treated with direct-acting antivirals (DAA). We describe the implementation of a comprehensive pharmaceutical care programme (CPCP) for HCV-infected patients treated with DAA in a tertiary-care hospital and provide data about health outcomes and costs. METHODS: Quasi-experimental study between 1 April 2015 and 30 June 2016. A group of hospital pharmacists collaborating on HCV infection implemented interventional measures for validation of drug prescriptions, detection of clinically relevant drug-drug interactions and adverse drug events (ADEs), and patient education...
August 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28833556/over-expression-of-p53-explains-isotretinoin-s-teratogenicity
#18
Bodo C Melnik
The precise molecular basis of retinoid embryopathy is yet unknown. This hypothesis predicts that isotretinoin (13-cis retinoic acid), the prodrug of all-trans retinoic acid (ATRA), exaggerates neural crest cell (NCC) apoptosis via upregulation of the pro-apoptotic transcription factor p53, the guardian of the genome. Increased p53 signaling is associated with Treacher Collins-, CHARGE-, and fetal alcohol syndrome, which exhibit dysmorphic craniofacial features resembling retinoid embryopathy. In addition, developmental studies of NCC homeostasis in the zebrafish support the pivotal role of p53...
August 20, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28821422/adhesion-molecules-chemokines-and-matrix-metallo-proteinases-response-after-albendazole-and-albendazole-plus-steroid-therapy-in-swine-neurocysticercosis
#19
Satyendra K Singh, Kashi N Prasad, Aloukick K Singh, Kamlesh K Gupta, Amrita Singh, Mukesh Tripathi, Rakesh K Gupta
The treatment of neurocysticercosis (NCC) varies with location, number and stage of the Taenia solium cysticerci (cysts). Albendazole (ABZ) effectively kills cysticerci, and subsequently induces neuro-inflammation facilitated by leukocyte infiltration. We hypothesize that immune response varies around drug responder (degenerating/dying) and non-responder (viable) cysts after ABZ and ABZ plus steroid (ABZS) therapy, which may determine the disease pathogenesis. Twenty cysticercotic swine were treated with ABZ (n = 10; group1) and ABZS (n = 10; group2)...
August 15, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28820689/reliability-of-diagnostic-criteria-for-neurocysticercosis-for-patients-with-ventricular-cystic-lesions-or-granulomas-a-systematic-review
#20
Javier A Bustos, Hector H García, Oscar H Del Brutto
Intraventricular neurocysticercosis (NCC) is a severe form of NCC requiring prompt diagnosis and treatment. We aimed to assess the reliability of the most recent version of diagnostic criteria for this form of NCC. Two systematic literature reviews were performed; one included case reports of patients with intraventricular cysticercosis and the other included case reports of patients with intraventricular cystic lesions or granulomas caused by infections other than NCC. All assessed cases were categorized according to the last revision of the long-standing Del Brutto's set of diagnostic criteria to determine its sensitivity, specificity, and predictive value for this form of NCC...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
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