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https://www.readbyqxmd.com/read/28343456/implementation-of-neurocritical-care-is-associated-with-improved-outcomes-in-traumatic-brain-injury
#1
Mypinder S Sekhon, Peter Gooderham, Brian Toyota, Navid Kherzi, Vivien Hu, Vinay K Dhingra, Morad S Hameed, Dean R Chittock, Donald E Griesdale
Background Traditionally, the delivery of dedicated neurocritical care (NCC) occurs in distinct NCC units and is associated with improved outcomes. Institution-specific logistical challenges pose barriers to the development of distinct NCC units; therefore, we developed a consultancy NCC service coupled with the implementation of invasive multimodal neuromonitoring, within a medical-surgical intensive care unit. Our objective was to evaluate the effect of a consultancy NCC program on neurologic outcomes in severe traumatic brain injury patients...
March 27, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28341239/calcineurin-inhibitors-block-sodium-chloride-cotransporter-dephosphorylation-in-response-to%C3%A2-high-potassium-intake
#2
Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Dietary potassium intake is inversely related to blood pressure and mortality. Moreover, the sodium-chloride cotransporter (NCC) plays an important role in blood pressure regulation and urinary potassium excretion in response to potassium intake. Previously, it was shown that NCC is activated by the WNK4-SPAK cascade and dephosphorylated by protein phosphatase. However, the mechanism of NCC regulation with acute potassium intake is still unclear. To identify the molecular mechanism of NCC regulation in response to potassium intake, we used adult C57BL/6 mice fed a 1...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28334780/eif4a3-deficient-human-ipscs-and-mouse-models-demonstrate-neural-crest-defects-that-underlie-richieri-costa-pereira-syndrome
#3
Emily E Miller, Gerson S Kobayashi, Camila M Musso, Miranda Allen, Felipe A A Ishiy, Luiz C de Caires Junior, Ernesto S G Guimarães, Karina Griesi-Oliveira, Roseli M Zechi-Ceide, Antonio Richieri-Costa, Debora R Bertola, Maria Rita Passos-Bueno, Debra L Silver
Biallelic loss-of-function mutations in the RNA binding protein EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS), an autosomal recessive condition mainly characterized by craniofacial and limb malformations. However, the pathogenic cellular mechanisms responsible for this syndrome are entirely unknown. Here we used two complementary approaches, patient-derived induced pluripotent stem cells (iPSCs) and conditional Eif4a3 mouse models, to demonstrate that defective Neural Crest Cell (NCC) development explains RCPS craniofacial abnormalities...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28331059/adaptive-changes-in-gfr-tubular-morphology-and-transport-in-subtotal-nephrectomized-kidneys-modeling-and-analysis
#4
Anita T Layton, Aurélie Edwards, Volker Vallon
Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevation in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the concomitant increases in filtered load and tubular transport capacity preserve homeostasis of water and salt. To accomplish that goal, we developed computational models to simulate solute transport and metabolism along nephron populations in a uninephrectomized (UNX) rat and a 5/6-nephrectomized (5/6-NX) rat...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28325349/nanocrystalline-cellulose-fullerene-novel-conjugates
#5
A Herreros-López, M Carini, T Da Ros, T Carofiglio, C Marega, V La Parola, V Rapozzi, L E Xodo, Ali A Alshatwi, C Hadad, M Prato
The covalent grafting of two amino-fullerene C60 derivatives (C60-LC-NH2 and C60-SC-NH2, LC=long chain and SC=short chain) onto the surface of TEMPO oxidized nanocrystalline cellulose (NCC-COOH) has been reported for the first time. These hybrids (NCC-LC-C60 and NCC-SC-C60) form stable colloidal suspensions at concentrations up to 0.5mg/mL and act as effective photosensitizers for singlet oxygen production as demonstrated by the oxidation of L-methionine-methyl ester to the corresponding sulphoxide. Using the same approach, in a one-pot reaction both a fluorescent target molecule (FITC-LC-NH2) and the C60-LC-NH2 derivative have been successfully attached covalently onto the NCC-COOH surface...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28325336/preparation-of-green-and-gelatin-free-nanocrystalline-cellulose-capsules
#6
Yapei Zhang, Qing Zhao, Huashan Wang, Xingyu Jiang, Ruitao Cha
The ambiguous source and uncontrolled solubility of gelatin make it crucial to develop gelatin capsule substitutes. Nanocrystalline cellulose (NCC) of excellent mechanical performance, good biocompatibility and green origin has drawn many attentions as a new class of biomaterials. In this work, NCC capsule was prepared by dipping method with PEG and glycerol as plasticizer. The effect of PEG and glycerol on the rheological property of NCC gel and the surface morphology of NCC capsule was evaluated. The disintegration time of NCC capsule meet the criteria in United States Pharmacopoeia (USP32-701)...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28316823/a-new-solvate-of-afatinib-a-specific-inhibitor-of-the-erbb-family-of-tyrosine-kinases
#7
Matthias Zeller, Gabriel Lima Barros de Araujo, Trev Parker, Amrinder Singh Rai, Stephen R Byrn
Afatinib (systematic name: N-{4-(3-chloro-4-fluoro-anilino)-7-[(tetra-hydro-furan-3-yl)-oxy]quinazolin-6-yl}-4-(di-methyl-amino)-but-2-enamide), is a specific in-hibitor of the ErbB family of tyrosine kinases. The free base form crystallizes from aceto-nitrile as a mixed water-aceto-nitrile solvent, C24H25ClFN5O3·0.25C2H3N·2H2O. It crystallizes with two independent mol-ecules (A and B) in the asymmetric unit of the chiral space group P4212, but exhibits close to perfect pseudo-inversion symmetry, emulating P4/ncc that relates the two mol-ecules to each other...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28314118/in-vitro-assay-development-and-hts-of-small-molecule-human-abad-17%C3%AE-hsd10-inhibitors-as-therapeutics-in-alzheimer-s-disease
#8
Laura Aitken, Gemma Baillie, Andrew Pannifer, Angus Morrison, Philip S Jones, Terry K Smith, Stuart P McElroy, Frank J Gunn-Moore
A major hallmark of Alzheimer's disease (AD) is the formation of neurotoxic aggregates composed of the amyloid-β peptide (Aβ). Aβ has been recognized to interact with numerous proteins, resulting in pathological changes to the metabolism of patients with AD. One such mitochondrial metabolic enzyme is amyloid-binding alcohol dehydrogenase (ABAD), where altered enzyme function caused by the Aβ-ABAD interaction is known to cause mitochondrial distress and cytotoxic effects, providing a feasible therapeutic target for AD drug development...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28289184/renal-tubular-ubiquitin-protein-ligase-nedd4-2-is-required-for-renal-adaptation-during-long-term-potassium-depletion
#9
Lama Al-Qusairi, Denis Basquin, Ankita Roy, Renuga Devi Rajaram, Marc P Maillard, Arohan R Subramanya, Olivier Staub
Adaptation of the organism to potassium (K(+)) deficiency requires precise coordination among organs involved in K(+) homeostasis, including muscle, liver, and kidney. How the latter performs functional and molecular changes to ensure K(+) retention is not well understood. Here, we investigated the role of ubiquitin-protein ligase NEDD4-2, which negatively regulates the epithelial sodium channel (ENaC), Na(+)/Cl(-) cotransporter (NCC), and with no-lysine-kinase 1 (WNK1). After dietary K(+) restriction for 2 weeks, compared with control littermates, inducible renal tubular NEDD4-2 knockout (Nedd4L(Pax8/LC1) ) mice exhibited severe hypokalemia and urinary K(+) wasting...
March 13, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28278478/abnormality-detection-in-correlated-gaussian-molecular-nano-networks-design-and-analysis
#10
Siavash Ghavami, Farshad Lahouti
A nano abnormality detection scheme (NADS) in molecular nano-networks is studied. This is motivated by the fact that early detection of diseases such as cancer play a crucial role in their successful treatment. The proposed NADS is in fact a two-tier network of sensor nano-machines (SNMs) in the first tier and a data-gathering node (DGN) at the sink. The SNMs detect the presence of competitor cells (abnormality) by variations in input and/or parameters of a nano-communications channel (NCC). The noise of SNMs as their nature suggest is considered correlated in time and space and herein assumed additive Gaussian...
March 2, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28274929/hydrochlorothiazide-treatment-increases-the-abundance-of-the-nacl-cotransporter-in-urinary-extracellular-vesicles-of-essential-hypertensive-patients
#11
Ganesh Pathare, Omar A Z Tutakhel, Mark C V D Wel, Luke M Shelton, Jaap Deinum, Jacques W Lenders, Joost G J Hoenderop, René J M Bindels
The thiazide-sensitive NaCl cotransporter (NCC), located apically in distal convoluted tubule epithelia, regulates the fine-tuning of renal sodium excretion. Three isoforms of NCC are generated through alternative splicing of the transcript, of which the third isoform has been the most extensively investigated in pathophysiological conditions. The aim of this study was to investigate the effect of different anti-hypertensive treatments on the abundance and phosphorylation of all three NCC isoforms in urinary extracellular vesicles (uEVs) of essential hypertensive patients...
March 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28267924/pathogen-induced-leaf-chlorosis-products-of-chlorophyll-breakdown-found-in-degreened-leaves-of-phytoplasma-infected-apple-malus-x-domestica-borkh-and-apricot-prunus-armeniaca-l-trees-relate-to-the-pheophorbide-a-oxygenase-phyllobilin-pathway
#12
Cecilia Mittelberger, Hacer Yalcinkaya, Christa Pichler, Johanna Gasser, Gerhard Scherzer, Theresia Erhart, Sandra Schumacher, Barbara Holzner, Katrin Janik, Peter Robatscher, Thomas Müller, Bernhard Kräutler, Michael Oberhuber
Phytoplasmoses such as Apple Proliferation (AP) and European Stone Fruit Yellows (ESFY) cause severe economic losses in fruit production. A common symptom of both phytoplasma diseases is the early yellowing or leaf chlorosis. Even though chlorosis is a well-studied symptom of biotic and abiotic stress, its biochemical pathways are hardly known. In particular, in this context, a potential role of the senescence-related pheophorbide a oxygenase/phyllobilin (PaO/PB) pathway is elusive, which degrades chlorophyll (Chl) to phyllobilins (PBs), most notably to colorless non-fluorescent Chl catabolites (NCCs)...
March 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28267746/systematic-review-and-meta-analysis-estimating-association-of-cysticercosis-and-neurocysticercosis-with-epilepsy
#13
Gabrielle Debacq, Luz M Moyano, Héctor H Garcia, Farid Boumediene, Benoit Marin, Edgard B Ngoungou, Pierre-Marie Preux
BACKGROUND: We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. METHODOLOGY: We conducted a systematic review of the literature on cysticercosis and epilepsy in the tropics, collecting data from case-control and cross-sectional studies. Exposure criteria for CC included one or more of the following: serum ELISA or EITB positivity, presence of subcutaneous cysts (both not verified and unverified by histology), histology consistent with calcified cysts, and brain CT scan consistent with NCC...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28267505/hydrophobic-kenaf-nanocrystalline-cellulose-for-the-binding-of-curcumin
#14
Norhidayu Zainuddin, Ishak Ahmad, Hanieh Kargarzadeh, Suria Ramli
Nanocrystalline cellulose (NCC) extracted from lignocellulosic materials has been actively investigated as a drug delivery excipients due to its large surface area, high aspect ratio, and biodegradability. In this study, the hydrophobically modified NCC was used as a drug delivery excipient of hydrophobic drug curcumin. The modification of NCC with a cationic surfactant, cetyl trimethylammonium bromide (CTAB) was used to modulate the loading of hydrophobic drugs that would not normally bind to NCC. The FTIR, Elemental analysis, XRD, TGA, and TEM were used to confirm the modification of NCC with CTAB...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28259696/comparison-of-strategies-for-catheter-ablation-of-focal-atrial-tachycardia-originating-near-the-his-bundle-region
#15
Evgeny Lyan, Mauro Toniolo, Alexey Tsyganov, Luca Rebellato, Alessandro Proclemer, Massimiliano Manfrin, Anatoly Nechepurenko, Alexandr Morozov, Ayan Abdrahmanov, Grigory Gromyko, Vitaly Lyashenko, Marina Yakovleva
BACKGROUND: Recent studies have suggested that para-Hisian atrial tachycardia (AT) can be successfully ablated from the right atrium (RA), left atrium (LA) or non-coronary cusp (NCC) in the aorta; however, the best approach remains unclear. OBJECTIVE: This study aimed to compare different approaches to radiofrequency catheter ablation (RFCA) of para-Hisian AT. METHODS: We retrospectively analyzed 68 consecutive patients (72% females, aged 61±13 years) treated with RFCA for this type of AT...
March 1, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28255646/mr-imaging-and-mr-cholangiopancreatography-of-cholangiocarcinoma-developing-in-printing-company-workers
#16
Koichi Koyama, Shoji Kubo, Ai Ueki, Taro Shimono, Shigekazu Takemura, Shogo Tanaka, Masahiko Kinoshita, Genya Hamano, Yukio Miki
PURPOSE: To retrospectively investigate magnetic resonance (MR) imaging findings of occupational cholangiocarcinoma (oCC) occurring among workers in printing companies in Japan, compared to those of non-occupational cholangiocarcinoma (nCC), primary sclerosing cholangitis (PSC), and age-matched normal controls (NORs). MATERIALS AND METHODS: Participants comprised 27 consecutive patients (oCC, n = 5; nCC, n = 8; PSC, n = 6; NOR, n = 8) who underwent MR imaging between May 2009 and October 2012...
March 2, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28247859/identification-of-major-dietary-patterns-in-korean-adults-and-their-association-with-cancer-risk-in-the-cancer-screening-examination-cohort
#17
G-A Wie, Y-A Cho, H-H Kang, K A Ryu, M-K Yoo, J Kim, S Shin, O K Chun, H Joung
BACKGROUND/OBJECTIVES: Cancer is the primary cause of disease-related death in Korea. The purposes of this study were to confirm the major dietary patterns and to evaluate whether there were associations between these identified dietary patterns and the risk of cancer based on data from the Cancer Screening Examination Cohort (CSEC) 2004-2008 of the National Cancer Center (NCC) of Korea. SUBJECTS/METHODS: This study included 8 024 subjects who completed a written survey on demographics and lifestyles, as well as a 3-day dietary record...
March 1, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28236577/epilepsy-surgery-and-neurocysticercosis-assessing-the-role-of-the-cysticercotic-lesion-in-medically-refractory-epilepsy
#18
REVIEW
Alejandro L Escalaya, Jorge G Burneo
There is increasing evidence of the existence of refractoriness to treatment with antiepileptic medications in those with NCC-related epilepsy. We performed a systematic review with the objective to determine the role of a cysticercotic lesion in this group of patients. We sought those manuscripts, including case reports, describing patients with NCC-related medically-intractable epilepsy who underwent epilepsy surgery and were seizure-free a year after. Only 10 manuscripts fulfilled inclusion and exclusion criteria...
February 21, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28226078/experimental-neurocysticercosis-absence-of-il-4-induces-lower-encephalitis
#19
Hidelberto Matos Silva, Marina Clare Vinaud, Ruy de Souza Lino
Methods: BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results: The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema...
February 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28224888/spherical-nanocrystalline-cellulose-ncc-from-oil-palm-empty-fruit-bunch-pulp-via-ultrasound-assisted-hydrolysis
#20
Z A Zianor Azrina, M Dalour H Beg, M Y Rosli, Ridzuan Ramli, Norhafzan Junadi, A K M Moshiul Alam
Nanocrystalline cellulose (NCC) was isolated from oil palm empty fruit bunch pulp (EFBP) using ultrasound assisted acid hydrolysis. The obtained NCC was analysed using FESEM, XRD, FTIR, and TGA, and compared with raw empty fruit bunch fibre (REFB), empty fruit bunch pulp (EFBP), and treated empty fruit bunch pulp (TEFBP). Based on FESEM analysis, it was found that NCC has a spherical shaped after acid hydrolysis with the assistance of ultrasound. This situation was different compared to previous studies that obtained rod-like shaped of NCC...
April 15, 2017: Carbohydrate Polymers
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