Fabio Pizza, Luca Vignatelli, Stefano Vandi, Corrado Zenesini, Francesco Biscarini, Christian Franceschini, Elena Antelmi, Francesca Ingravallo, Emmanuel Mignot, Oliviero Bruni, Lino Nobili, Pierangelo Veggiotti, Raffaele Ferri, Giuseppe Plazzi
BACKGROUND AND OBJECTIVES: Narcolepsy type 1 (NT1) is still largely underdiagnosed or diagnosed too late in children. Difficulties in obtaining rapid and reliable diagnostic evaluations of the condition in clinical practice partially explain this problem. Predictors of NT1 include cataplexy and sleep-onset REM periods (SOREMPs), documented during nocturnal polysomnography (N-PSG) or through the multiple sleep latency test (MSLT), although low CSF hypocretin-1 (CSF hcrt-1) is the definitive biological disease marker...
January 9, 2024: Neurology