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Hypersomnia

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https://www.readbyqxmd.com/read/29340766/wanted-a%C3%A2-better-cut-off-value-for-the-epworth-sleepiness-scale
#1
Karin Trimmel, Magdalena Żebrowska, Marion Böck, Andrijana Stefanic, Daniel Mayer, Gerhard Klösch, Eduard Auff, Stefan Seidel
BACKGROUND: Excessive daytime sleepiness (EDS) is the main complaint in many neurological sleep disorders, such as idiopathic hypersomnia, narcolepsy, or obstructive sleep apnea/hypopnea syndrome (OSAS). The validity of the Epworth Sleepiness Scale (ESS) as a screening tool for EDS remains controversial. We therefore investigated (1) the interrelation of the ESS total score and the mean sleep latency (MSL) during the multiple sleep latency test (MSLT) and (2) the diagnostic accuracy of the ESS total score to detect EDS in patients with the chief complaint of subjective EDS...
January 16, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29332107/the-sleep-architecture-of-saudi-arabian-patients-with-kleine-levin-syndrome
#2
Saad M Al Shareef, Aljohara S Almeneessier, Omeima Hammad, Richard M Smith, Ahmed S BaHammam
To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. Methods: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29323727/alternative-diagnostic-criteria-for-idiopathic-hypersomnia-a-32-hour-protocol
#3
Elisa Evangelista, Régis Lopez, Lucie Barateau, Sofiene Chenini, Adriana Bosco, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: To assess the diagnostic value of extended sleep duration on a controlled 32-hour bed-rest protocol in idiopathic hypersomnia (IH). METHODS: 116 patients with high suspicion of IH (37 clear-cut-IH according to multiple sleep latency test criteria and 79 probable-IH), 32 with hypersomnolence associated with a comorbid disorder (non-IH) and 21 controls underwent a polysomnography, modified-sleep latency tests and a 32-h bed-rest protocol. Receiver operating characteristic curves were used to find optimal total sleep time (TST) cut-off values on various periods that discriminate patients to controls...
January 11, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29289963/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-ii-diagnosis-and-treatment
#4
REVIEW
Adam Wichniak, Konrad S Jankowski, Michał Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
AIM: Circadian rhythm sleep-wake disorders (CRSWD) are a group of disorders, in which the timing of sleep and wakefulness significantly differs from a patient's expectations or socially acceptable times. The aimof the article is to present the current principles for the diagnosis and treatment of CRSWD in adults and children. METHOD: Guidelines proposed as CRSWD treatment standard are based on the recommendations from the scientific societies involved in the sleep research and medicine...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29276000/a-standardized-test-to-document-cataplexy
#5
Stefano Vandi, Fabio Pizza, Elena Antelmi, Giulia Neccia, Martina Iloti, Alice Mazzoni, Patrizia Avoni, Giuseppe Plazzi
OBJECTIVE/BACKGROUND: Cataplexy is the pathognomonic symptom of narcolepsy type 1 (NT1). Since it is considered difficult to be directly observed or documented by clinicians, its diagnosis relies mainly on history taking. Our study aimed at testing the feasibility of a standardized video recording procedure under emotional stimulation to document cataplexy in the diagnostic work-up of suspected hypersomnia of central origin. PATIENTS/METHODS: Two-hundred-eight consecutive patients underwent the diagnostic work-up and reached the final diagnosis of NT1 (n = 133), idiopathic hypersomnia or narcolepsy type 2 (IH/NT2 group, n = 33), or subjective excessive daytime sleepiness (sEDS group, n = 42)...
October 9, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29262477/-clinical-analysis-of-four-cases-of-anti-gq1b-syndrome
#6
X Y Yang, T L Han, W H Zhang, S Zhang, F Fang
Objective: To investigate the clinical manifestations, laboratory findings, treatment and outcome of anti-GQ1b antibody syndrome. Method: The clinical manifestations, laboratory examination, diagnosis, treatment and prognosis of (4 patients 4 male patients, from 4 to 12 years) with anti-GQ1b syndrome in Beijing Children's Hospital affiliated to Capital Medical University from 2015 to 2016 were retrospectively analyzed. Result: All 4 children presented with ataxia. Case 1 showed impaired speech, ptosis and weakness of arms; case 2 and 3 had external ophthalmoplegia, weakness of limbs; case 4 presented hypersomnia, irritability and hallucinations...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29250981/update-on-treatment-for-idiopathic-hypersomnia
#7
Elisa Evangelista, Régis Lopez, Yves Dauvilliers
Idiopathic hypersomnia (IH) is a poorly characterized orphan central disorder of hypersomnolence responsible for excessive daytime sleepiness (EDS), prolonged nighttime sleep and sleep inertia that often require long-term symptomatic stimulant medication. To date, no drug has currently the authorization for the treatment of IH patients worldwide. Areas covered: The authors reviewed data on pharmacological treatment of IH obtained from published literature (Medline/PubMed/Web of Science) and Clinicaltrial.gov database from 1997 to 2017...
January 3, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29249902/test-retest-reliability-of-two-consecutive-mean-sleep-latency-tests-in-patients-with-hypersomnia
#8
Younghoon Kwon, Louis Kazaglis, Yeilim Cho, Michael J Howell, Mark W Mahowald
Reliability of mean sleep latency testing (MSLT) over consecutive days in patients with hypersomnia is unknown. We reviewed MSLTs of patients with hypersomnia without cataplexy who underwent our two consecutive MSLT protocol (N=29). Average MSLs were 10.9 and 10.9 minutes for days 1 and 2, respectively. Agreement for pathological hypersomnia (defined as MSL≤8 minutes) between MSLT days showed k=0.85 for all (N=29) and k=0.76 for those without sleep apnea (N=20). In patients with subjective complaints of hypersomnia, a single MSLT is sufficient (vs...
October 2017: Sleep and Biological Rhythms
https://www.readbyqxmd.com/read/29198301/the-mslt-is-repeatable-in-narcolepsy-type-1-but-not-narcolepsy-type-2-a-retrospective-patient-study
#9
Chad Ruoff, Fabio Pizza, Lynn Marie Trotti, Karel Sonka, Stefano Vandi, Joseph Cheung, Swaroop Pinto, Mali Einen, Narong Simakajornboon, Fang Han, Paul Peppard, Sona Nevsimalova, Giuseppe Plazzi, David Rye, Emmanuel Mignot
STUDY OBJECTIVES: To examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) according to the criteria of the International Classification of Sleep Disorders, Third Edition (ICSD-3). METHODS: Repeatability of the MSLT was retrospectively evaluated in NT1 (n = 60) and NT2 (n = 54) cases, and controls (n = 15). All subjects had documented HLA-DQB1*06:02 status and/or hypocretin-1 levels from cerebrospinal fluid...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29163018/brain-networks-implicated-in-seasonal-affective-disorder-a-neuroimaging-pet-study-of-the-serotonin-transporter
#10
Martin Nørgaard, Melanie Ganz, Claus Svarer, Patrick M Fisher, Nathan W Churchill, Vincent Beliveau, Cheryl Grady, Stephen C Strother, Gitte M Knudsen
Background: Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder characterized by seasonally occurring depression that often presents with atypical vegetative symptoms such as hypersomnia and carbohydrate craving. It has recently been shown that unlike healthy people, patients with SAD fail to globally downregulate their cerebral serotonin transporter (5-HTT) in winter, and that this effect seemed to be particularly pronounced in female S-carriers of the 5-HTTLPR genotype. The purpose of this study was to identify a 5-HTT brain network that accounts for the adaption to the environmental stressor of winter in females with the short 5-HTTLPR genotype, a specific subgroup previously reported to be at increased risk for developing SAD...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29117891/recurrent-hypersomnia-and-autonomic-dysregulation-in-posttraumatic-stress-disorder
#11
Madhulika A Gupta
No abstract text is available yet for this article.
November 1, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29116485/prevalence-risk-factors-and-response-to-treatment-for-hypersomnia-of-central-origin-in-survivors-of-childhood-brain-tumors
#12
Raja B Khan, Thomas E Merchant, Zsila S Sadighi, Mercedes S Bello, Zhaohua Lu, April Sykes, Merrill S Wise, Valerie M Crabtree, Jennifer Zabrowski, Andrea Simmons, Mary E Clark, Belinda N Mandrell
Daytime sleepiness is recognized in childhood brain tumor survivors. Our objective was to determine prevalence, risk factors for PSG/MLST proven hypersomnia/narcolepsy, and response to stimulants in childhood brain tumor survivors. Standard PSG/MSLT criteria were used to diagnose hypersomnia/narcolepsy. Medical records of brain tumor survivors having undergone a PSG/MSLT were reviewed for the diagnostic code of hypersomnia/narcolepsy. Survivors with hypersomnia/narcolepsy were matched with 2-3 survivors without reported hypersomnia/narcolepsy by age at tumor diagnosis, gender, and time from tumor diagnosis...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29100757/an-uplc-ms-ms-method-for-quantifying-tetrandrine-and-its-metabolite-berbamine-in-human-blood-application-to-a-human-pharmacokinetic-study
#13
Guangyi Yang, Chenning Zhang, Pei Hu, Meiling Zhu, Ming Hu, Song Gao
Tetrandrine (TET) was approved by the China Food and Drug Administration (CFDA) for the treatment of silicosis. However, patients can't use this effective drug chronically due to side effects such as hypersomnia, asthenia, etc. The purpose of this study is to develop an UPLC-MS/MS method to quantify TET and its major metabolite and apply the method in a single dose human pharmacokinetic study. A Restek UItra BiPh column (100×2.1mm, 5μm) was used with acetonitrile and 0.1% formic acid in water as the mobile phases...
October 26, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29099966/test-retest-reliability-of-the-multiple-sleep-latency-test-in-central-disorders-of-hypersomnolence
#14
Régis Lopez, Anis Doukkali, Lucie Barateau, Elisa Evangelista, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers
Study objectives: To assess the test-retest reliability of the polysomnography-multiple sleep latency test (PSG-MSLT) diagnostic classification and measures, and to study the determinants of its variability in patients with narcolepsy type 1 (NT1) or with non-cataplectic central disorders of hypersomnolence (NCHS): type 2 (NT2), idiopathic hypersomnia (IH) and unspecified hypersomnolence (UnsEDS). Methods: PSG-MSLT in drug-free conditions was administered twice (median interval of 1...
November 1, 2017: Sleep
https://www.readbyqxmd.com/read/29047171/effectiveness-and-side-effect-profile-of-stimulant-therapy-as-monotherapy-and-in-combination-in-the-central-hypersomnias-in-clinical-practice
#15
Chiraag Thakrar, Kishankumar Patel, Grainne D'ancona, Brian D Kent, Alexander Nesbitt, Hugh Selsick, Joerg Steier, Ivana Rosenzweig, Adrian J Williams, Guy D Leschziner, Panagis Drakatos
Effectiveness and side-effect profile data on pharmacotherapy for daytime sleepiness in central hypersomnias are based largely upon randomized controlled trials. Evidence regarding the use of combination therapy is scant. The aim of this study was to examine the effectiveness and occurrence of drug-related side effects of these drugs in routine clinical practice. Adult patients diagnosed with a central hypersomnia during a 54-month period at a tertiary sleep disorders centre were identified retrospectively...
October 19, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29033570/atypical-depression-current-perspectives
#16
REVIEW
Dorota Łojko, Janusz K Rybakowski
The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29026774/atypical-kleine-levin-syndrome-an-elusive-entity
#17
Swarndeep Singh, Saurabh Kumar, Rohit Verma, Nand Kumar
Kleine-Levin syndrome (KLS) is a rare disorder (around 1.5 cases per million population), often presenting with triad of recurrent episodes of hypersomnia, hyperphagia, and hypersexuality. However, cases of atypical KLS with features opposite to that being commonly reported are often misdiagnosed as psychosis and present as a diagnostic challenge for the physicians, psychiatrists, and neurologists. We describe a case of atypical KLS which was misdiagnosed as unspecified nonorganic psychosis previously, highlighting the various points which would be helpful in identifying and diagnosing cases of atypical KLS in future...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026583/a-case-of-hypersomnia-due-to-bilateral-thalamic-stroke
#18
Mohammed Osman, Ahmed Abdalla, Mohammed Al-Qasmi, Ghassan Bachuwa
Bilateral thalamic infarction (BTI) can present as sleep-like coma without focal neurological signs which can lead to delay in the diagnosis. Due to the diagnostic challenge, treatment is often delayed. The early use of DWI-MRI in suspected cases can help in the early diagnosis and treatment.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28993975/mood-disorders-are-highly-prevalent-in-patients-investigated-with-a-multiple-sleep-latency-test
#19
Eve J Denton, Maree Barnes, Tom Churchward, Melinda Jackson, Allison Collins, Matthew T Naughton, Eli Dabscheck
PURPOSE: Excessive daytime sleepiness (EDS) is a debilitating symptom which occurs commonly in both primary sleep and mood disorders. The prevalence of mood disorders in patients with EDS, evaluated objectively with a mean sleep latency test (MSLT), has not been reported. We hypothesize that mood disorders are highly prevalent in patients being investigated for EDS. This study aims to report the prevalence of mood disorder in the MSLT population and investigate the association between mood disorder and objective and subjective scores of sleepiness...
October 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28972930/insomnia-and-hypersomnia-in-major-depressive-episode-prevalence-sociodemographic-characteristics-and-psychiatric-comorbidity-in-a-population-based-study
#20
Pierre A Geoffroy, Nicolas Hoertel, Bruno Etain, Frank Bellivier, Richard Delorme, Frédéric Limosin, Hugo Peyre
OBJECTIVES: To examine (i) the frequency of different sleep complaints (early wake-up, trouble falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic characteristics and psychiatric comorbidity associated with each type of sleep profiles. METHODS: Data were drawn from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative survey of the US adult population (wave 1, 2001-2002; wave 2, 2004-2005)...
January 15, 2018: Journal of Affective Disorders
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