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Salidroside

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https://www.readbyqxmd.com/read/28931916/salidroside-ameliorates-sepsis-induced-acute-lung-injury-and-mortality-via-downregulating-nf-%C3%AE%C2%BAb-and-hmgb1-pathways-through-the-upregulation-of-sirt1
#1
Kuo-Cheng Lan, Sung-Chuan Chao, Hsiao-Yi Wu, Chia-Lien Chiang, Ching-Chia Wang, Shing-Hwa Liu, Te-I Weng
Sepsis is a life-threatening medical condition. Salidroside, a substance isolated from Rhodiola rosea, possesses antioxidant and anti-inflammatory properties. The effect and mechanism of salidroside on sepsis-induced acute lung injury still remains to be well clarified. Here, we investigated the effect and mechanism of salidroside on septic mouse models and explored the role of salidroside-upregulated SIRT1. Salidroside inhibited the inflammatory responses and HMGB1 productions in bacterial lipopolysaccharide (LPS)-treated macrophages and mice...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905500/salidroside-suppressing-lps-induced-myocardial-injury-by-inhibiting-ros-mediated-pi3k-akt-mtor-pathway-in-vitro-and-in-vivo
#2
Lvyi Chen, Peng Liu, Xin Feng, Chunhua Ma
The purpose of the present study was to investigate the effect of salidroside (Sal) on myocardial injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg/kg), LPS plus dexamethasone (2 mg/kg), LPS plus Sal groups with different Sal doses (20, 40 mg/kg). Hemodynamic measurement and haematoxylin and eosin staining were performed. Serum levels of creatine kinase (CK), lactate dehydrogenase, the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-px), glutathione, tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) were measured after the rats were killed...
September 14, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28901519/salidroside-a-scavenger-of-ros-enhances-the-radioprotective-effect-of-ex-rad%C3%A2-via-a-p53-dependent-apoptotic-pathway
#3
Tian Feng, Libin Wang, Nan Zhou, Chang Liu, Jiahui Cui, Rangxin Wu, Juan Jing, Shengyong Zhang, Hui Chen, Siwang Wang
Salidroside (Sal), the predominant component of a Chinese medicinal herb, Rhodiola rosea L., has become an attractive bioagent due to its significant anti-radiation, antioxidant and immune adjustment effects. We explored the radioprotective effect of Sal to ascertain whether it could enhance the anti-radiation effect of ON 01210.Na (Ex-RAD®) in vivo and in vitro, and elucidate its underlying mechanism. Our data demonstrated that Sal inhibited radiation-induced apoptosis, scavenged reactive oxygen species (ROS), and decreased the DNA damage of human umbilical vein endothelial cells (HUVECs)...
September 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28889522/salidroside-a-chemopreventive-glycoside-diminishes-cytotoxic-effect-of-cisplatin-in-vitro
#4
Martina Zduriencikova, Dana Cholujova, Jozef Duraj, Maria Mastihubova, Vladimir Mastihuba, Elena Karnisova Potocka, Eliska Galova, Andrea Sevcovicova, Martina Klapakova, Eva Horvathova
Natural products represent the source or the inspiration for the majority of the active ingredients of medicines because of their structural diversity and a wide range of biological effects. Our aims in this study were (i) to synthesize enzymatically salidroside (SAL), the most effective phenylethanoid glycoside in Rhodiola species; (ii) to examine its antioxidant capacity using cell-free assays (reducing power, DPPH radicals scavenging and Fe(2+) -chelating assays); (iii) to assess its DNA-protective potential on plasmid DNA (DNA topology assay) and in HepG2 cells (comet assay) damaged by Fe(2+) ions and hydrogen peroxide, respectively; and (iv) to investigate the effects of SAL, cisplatin (CDDP) and combined treatments of SAL + CDDP on cell viability (MTT test), level of DNA damage (comet assay), proliferation, cell cycle (flow cytometry) and the expression of signalling molecules associated with cell growth and apoptotic pathways (western immunoblotting)...
September 10, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28872612/fructus-ligustri-lucidi-in-osteoporosis-a-review-of-its-pharmacology-phytochemistry-pharmacokinetics-and-safety
#5
REVIEW
Beibei Chen, Lili Wang, Lin Li, Ruyuan Zhu, Haixia Liu, Chenyue Liu, Rufeng Ma, Qiangqiang Jia, Dandan Zhao, Jianzhao Niu, Min Fu, Sihua Gao, Dongwei Zhang
Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28855701/degradation-of-phenylethanoid-glycosides-in-osmanthus-fragrans-lour-flowers-and-its-effect-on-anti-hypoxia-activity
#6
Fei Zhou, Yajing Zhao, Maiquan Li, Tao Xu, Liuquan Zhang, Baiyi Lu, Xiaodan Wu, Zhiwei Ge
This study was aimed at investigating the chemical stability (the thermal, light and pH stability) of phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers, identifying the degradation products of acteoside and salidroside (major PhGs in O. fragrans flowers) by UPLC-QTOF-MS and studying the anti-hypoxia activity of PhGs after degradation. The degradation of PhGs followed first-order reaction kinetics, and the rate constant of acteoside (4.3 to 203.4 × 10(-3) day(-1)) was higher than that of salidroside (3...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831032/salidroside-reduces-high-glucose-induced-podocyte-apoptosis-and-oxidative-stress-via-upregulating-heme-oxygenase-1-ho-1-expression
#7
Hua Lu, Ying Li, Tao Zhang, Maodong Liu, Yanqing Chi, Shuxia Liu, Yonghong Shi
BACKGROUND Hyperglycemia is one of the most dangerous factors causing diabetic nephropathy. Salidroside is considered to have the effects of reducing oxidative stress damage and improving cell viability. This study was performed to investigate whether and how salidroside reduces high-glucose (HG)-induced apoptosis in mouse podocytes. MATERIAL AND METHODS We examined whether salidroside could decrease HG-induced podocyte oxidative stress and podocyte apoptosis in vitro. The potential signaling pathways were also investigated...
August 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28803422/salidroside-improved-cerebrovascular-vasodilation-in-streptozotocin-induced-diabetic-rats-through-restoring-the-function-of-bkca-channel-in-smooth-muscle-cells
#8
Yu-Guang Ma, Jun-Wei Wang, Yin-Bin Zhang, Bao-Feng Wang, Zhi-Jun Dai, Man-Jiang Xie, Hua-Feng Kang
Vessel disease is a kind of severe complication in diabetic patients. However, few pharmacologic agents can directly recover diabetic vascular function. Salidroside (SAL), a major ingredient from Rhodiola rosea, has been found to have an obvious hypoglycemic effect and a beneficial protection on vascular function in diabetes. However, whether SAL is a suitable treatment for diabetes has not so far been evaluated and the underlying mechanisms remain unknown. The present work aims to (1) investigate the potential effects of SAL on cerebrovascular relaxation in streptozotocin-induced diabetic rats or when exposed to acute hyperglycemia condition and (2) examine whether function of the BKCa channel is involved in SAL treatment for diabetic vascular relaxation...
August 12, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28798798/the-protective-effect-of-salidroside-on-hypoxia-induced-corpus-cavernosum-smooth-muscle-cell-phenotypic-transformation
#9
Xiang Zhang, Jian-Feng Zhao, Fan Zhao, Jun-Feng Yan, Fan Yang, Xiao-Jun Huang, Gang Chen, Hui-Ying Fu, Bo-Dong Lv
Salidroside, a major active ingredient isolated from Rhodiola rosea, has a long application in Chinese medical history. It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28747920/unraveling-key-metabolomic-alterations-in-wheat-embryos-derived-from-freshly-harvested-and-water-imbibed-seeds-of-two-wheat-cultivars-with-contrasting-dormancy-status
#10
Aayudh Das, Dea-Wook Kim, Pramod Khadka, Randeep Rakwal, Jai S Rohila
Untimely rains in wheat fields during harvest season can cause pre-harvest sprouting (PHS), which deteriorates the yield and quality of wheat crop. Metabolic homeostasis of the embryo plays a role in seed dormancy, determining the status of the maturing grains either as dormant (PHS-tolerant) or non-dormant (PHS-susceptible). Very little is known for direct measurements of global metabolites in embryonic tissues of dormant and non-dormant wheat seeds. In this study, physiologically matured and freshly harvested wheat seeds of PHS-tolerant (cv...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28741143/salidroside-ameliorates-diabetic-neuropathic-pain-in-rats-by-inhibiting-neuroinflammation
#11
Gui-Lian Ni, Rong Cui, Ai-Min Shao, Zhong-Min Wu
More than half of diabetic patients suffer from intractable neuropathic pain. As inflammation plays an important role in diabetic neuropathic pain, anti-inflammatory drugs might have therapeutic potentials for neuropathic pain. Salidroside (SAL), a phenylpropanoid glucoside, modulates a variety of cell functions, including inflammation. Here, we explored anti-nociceptive and anti-inflammatory effects of SAL on Zucker diabetic fatty rats with type 2 diabetes (DM rats). DM rats were tested for mechanical and thermal hyperalgesia using von Frey filament and plantar hot box test, respectively...
July 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28721018/salidroside-pretreatment-attenuates-apoptosis-and-autophagy-during-hepatic-ischemia-reperfusion-injury-by-inhibiting-the-mitogen-activated-protein-kinase-pathway-in-mice
#12
Jiao Feng, Qinghui Zhang, Wenhui Mo, Liwei Wu, Sainan Li, Jingjing Li, Tong Liu, Shizan Xu, Xiaoming Fan, Chuanyong Guo
Ischemia-reperfusion injury (IRI) contributes to liver damage in many clinical situations, such as liver resection and liver transplantation. In the present study, we investigated the effects of the antioxidant, anti-inflammatory, and anticancer agent salidroside (Sal) on hepatic IRI in mice. The mice were randomly divided into six groups: normal control, Sham, Sal (20 mg/kg), IRI, IRI + Sal (10 mg/kg), and IRI + Sal (20 mg/kg). We measured liver enzymes, proinflammatory cytokines, TNF-α and interleukin-6, and apoptosis- and autophagy-related marker proteins at 2, 8, and 24 hours after reperfusion...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28714019/salidroside-protects-pc12-cells-from-a%C3%AE-1%C3%A2-40%C3%A2-induced-cytotoxicity-by-regulating-the-nicotinamide-phosphoribosyltransferase-signaling-pathway
#13
Xujiao Huang, Sanli Xing, Chuan Chen, Zhihua Yu, Jiulin Chen
Alzheimer's disease (AD) is the most common type of senile dementia, which often develops in elderly or presenile individuals. As one of the pathological features of AD, amyloid β‑protein (Aβ) causes energy dysmetabolism, thereby inducing cellular damage and apoptosis. Salidroside is the main active component of the traditional Chinese medicine Rhodiola. Previous studies have demonstrated that salidroside exerts a regulatory role in energy metabolism. However, the role and the mechanism of action of salidroside in AD remain unclear...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28680451/the-proliferation-enhancing-effects-of-salidroside-on-schwann-cells-in-vitro
#14
Hui Liu, Peizhen Lv, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng, Jinmin Zhao
Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects. Recent studies show that salidroside has neurotrophic and neuroprotective effects. However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied. In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28680327/different-effects-of-feeding-pregnant-and-lactating-mice-rhodiola-kirilowii-aqueous-and-hydro-alcoholic-extracts-on-their-serum-angiogenic-activity-and-content-of-selected-polyphenols
#15
Robert Zdanowski, Ewa Skopińska-Różewska, Jacek Wilczak, Anna Borecka, Aneta Lewicka, Sławomir Lewicki
Angiogenesis plays an important role in many physiological processes, among them the formation of tissues and organs during embryogenesis. A lot of medicinal plants exhibit angiomodulatory properties. This creates the need for a thorough check of whether the plant extracts that we would like to give to pregnant women in order to increase their resistance to bacterial or viral infection will have negative effects on angiogenesis, and consequently on fetal development. This paper seeks to investigate the effect of serum of pregnant and nursing Balb/c mice that received aqueous (RKW) or hydro-alcoholic (RKW-A) R...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28672961/salidroside-inhibits-high-glucose-induced-proliferation-of-vascular-smooth-muscle-cells-via-inhibiting-mitochondrial-fission-and-oxidative-stress
#16
Xinyu Zhuang, Alimujiang Maimaitijiang, Yong Li, Haiming Shi, Xiaofei Jiang
The mitochondria are highly dynamic organelles, carefully maintaining network homeostasis by regulating mitochondrial fusion and fission. Mitochondrial dynamics are involved in the regulation of a variety of pathophysiological processes, including cell proliferation. Oxidative stress serves an important role in the remodeling of arterial vascular tissue in diabetic patients by affecting the proliferation of vascular smooth muscle cells (VSMCs). Salidroside is the primary active component of Rhodiola rosea and has been demonstrated to be an antioxidant with cardio- and vascular-protective effects, in addition to improving glucose metabolism...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28638921/-protective-effect-of-synthetic-salidroside-on-acute-lung-injury-in-rats
#17
Qian Huang, Yan-Chun Cai, Xiao-Li Wei, Jin-Long Wu, Ru-Huan Mei, Xiao-Lan Hu
To study the protective effect and mechanism of synthetic salidroside on acute lung injury (ALI) induced by lipopolysaccharide (LPS), male Sprague-Dawley (SD) rats were randomly divided into saline control group, 3 mg/kg LPS model group, different doses of salidroside groups (5, 20 and 80 mg/kg), and 5 mg/kg dexamethasone group. Intratracheal LPS instillation was used to establish the ALI model 0.5 h after intraperitoneal injection of salidroside or dexamethasone, and the rats were sacrificed 6 h later. Lung wet/dry weight ratio (W/D) was calculated...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28566694/production-of-three-phenylethanoids-tyrosol-hydroxytyrosol-and-salidroside-using-plant-genes-expressing-in-escherichia-coli
#18
Daeun Chung, So Yeon Kim, Joong-Hoon Ahn
Polyphenols, which include phenolic acids, flavonoids, stilbenes, and phenylethanoids, are generally known as useful antioxidants. Tyrosol, hydroxytyrosol, and salidroside are typical phenylethanoids. Phenylethanoids are found in plants such as olive, green tea, and Rhodiola and have various biological activities, including the prevention of cardiovascular diseases, cancer, and brain damage. We used Escherichia coli to synthesize three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside. To synthesize tyrosol, the aromatic aldehyde synthase (AAS) was expressed in E...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539713/content-determination-of-phenylpropanoids-and-enhancing-exercise-ability-of-effective-fractions-in-pedicularis-densispica
#19
Hongbiao Chu, Zhihua Zhang, Dong Chen, Xi Wang, Qilong Tu
BACKGROUND: Most researches were focused on chemical constituents and bioactivities of Pedicularis. However, there were a few reports on simultaneous determination of the series phenylpropanoids compounds in Pedicularis by High Performance Liquid Chromatography (HPLC). OBJECTIVE: To establish an HPLC method for simultaneous determination of salidroside, verbascoside, iso-verbascoside, leucoseptoside A, jionoside D and martynoside in Pedicularis densispica (PD), and to assess the enhancing exercise ability of effective fractions of phenylpropanoids (EFP)...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28526985/salidroside-attenuates-lps-induced-acute-lung-injury-in-rats
#20
Liu Jingyan, Guo Yujuan, Yang Yiming, Zhu Lingpeng, Yan Tianhua, Miao Mingxing
The purpose of the present study was to investigate the effects of salidroside (Sal) on lung injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg kg(-1)), LPS plus dexamethasone (2 mg kg(-1)), and LPS plus Sal groups with different Sal doses (20 mg kg(-1), 40 mg kg(-1)). Wet-to-dry weight (W/D) ratio was performed. Hematoxylin-eosin (HE) staining of lung was performed. Lung level of myeloperoxidase (MPO) was measured...
May 19, 2017: Inflammation
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