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Salidroside

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https://www.readbyqxmd.com/read/29329019/salidroside-influences-the-cellular-cross-talk-of-human-fetal-lung-diploid-fibroblasts-a-proteomic-approach
#1
Wenmin Xing, Wenyan Gao, Huili Su, Sanying Wang, Jing Zhang, Genxiang Mao, Jing Yan
Senescence is a complex multiple factor proces, which is still poorly understood. The purpose of this study was to find the proteome of cultured human fetal lung diploid fibroblasts (2BS) of different population doubling (PD), as well as the altered proteome induced by salidroside (SAL) in 2BS cells. Proteins were identified by two-dimensional electrophoresis (2-DE) combining matrix-assisted laser desorption/ionization-time and flight mass spectrometry (MAL DI-TOF/MS). As a result, we found 16 proteins with two-fold variations in senescent cells or after SAL treatment, some being reduced such as reticulocalbin-1, heat shock protein beta-6, elongation factor 1-delta, F-actin-capping protein subunit alpha-1, and chloride intracellular channel 1...
January 5, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29289557/salidroside-attenuates-endothelial-cellular-senescence-via-decreasing-the-expression-of-inflammatory-cytokines-and-increasing-the-expression-of-sirt3
#2
Sha-Sha Xing, Jian Li, Lin Chen, Ya-Fei Yang, Ping-Lin He, Jun Li, Jin Yang
OBJECTIVE: Endothelial cellular senescence is an important contributor to the endothelial dysfunction and atherosclerosis. Our previous studies suggested that salidroside (SAL) can alleviate atherosclerosis and protect endothelial cells against oxidative stress induced damage. However, the effect and mechanism of SAL on endothelial cellular senescence is still unclear. Here, we investigated the underlying mechanisms of SAL on preventing endothelial cellular premature senescence. METHODS AND RESULTS: We established a hyperhomocysteinemia (HHcy)mouse model via high methionine diet (HMD) to explore the protective effect of SAL...
December 28, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29286130/salidroside-inhibits-steroid-induced-avascular-necrosis-of-the-femoral-head-via-the-pi3k-akt-signaling-pathway-in%C3%A2-vitro-and-in%C3%A2-vivo-studies
#3
Xing-He Xue, Zhen-Hua Feng, Zhen-Xing Li, Xiao-Yun Pan
Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid‑induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti‑apoptotic effect on neurocytes by activating the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. In the present study, primary osteoblasts were used in vitro and in rats in vivo to determine the anti-apoptotic effect of Sal on SANFH...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29277428/complete-pathway-elucidation-and-heterologous-reconstitution-of-rhodiola-salidroside-biosynthesis
#4
Michael P Torrens-Spence, Tomáš Pluskal, Fu-Shuang Li, Valentina Carballo, Jing-Ke Weng
Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their anti-fatigue and anti-anoxia roles in traditional medicine, Rhodiola total extract and salidroside have also displayed medicinal properties as anti-cardiovascular diseases and anti-cancer agents. The resulting surge in global demand of Rhodiola plants and salidroside has driven some species close to extinction. Here, we report the full elucidation of Rhodiola salidroside biosynthetic pathway utilizing the first comprehensive transcriptomics and metabolomics datasets for Rhodiola rosea...
December 19, 2017: Molecular Plant
https://www.readbyqxmd.com/read/29246220/inhibition-of-autophagy-enhances-synergistic-effects-of-salidroside-and-anti-tumor-agents-against-colorectal-cancer
#5
Hai Li, Chen Chen
BACKGROUND: Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may function as inducers of autophagy of cancer cells. In general, autophagy confers survival advantage for cells responding to stress conditions, thus representing an important mechanism for chemo-resistance. This study was aimed to investigate the effectiveness of combined use of Salidroside (Sal, a phenylpropanoid glycosides from Rhodiola rosea L) with anti-tumor agents against colorectal cancer (CRC) cells, and moreover to evaluate the potential role of autophagy in the combined therapy...
December 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29242120/osteoprotective-effects-of-salidroside-in-ovariectomized-mice-and-diabetic-mice
#6
Xiang-Fan Chen, Xiao-Li Li, Min Yang, Yan Song, Yan Zhang
Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined. This study was performed to investigate if salidroside could protect against bone injuries induced by estrogen deficiency or hyperglycemia through modulating calcium homeostasis. Ovariectomized (OVX) mice and diabetic mice were treated with salidroside (20mg/kg) for 6 weeks...
December 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29234413/salidroside-protects-against-mpp-induced-neuronal-injury-through-dj-1-nrf2-antioxidant-pathway
#7
Leitao Wu, Hang Xu, Liang Cao, Tao Li, Ruru Li, Yang Feng, Jianzong Chen, Jing Ma
Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have found that salidroside (Sal) exhibited neuroprotective effects against MPP+ toxicity. However, the molecular mechanism is not fully understood. In this study, we found that Sal significantly prevented MPP+-induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH-SY5Y cells. Moreover, silencing of Nrf2 significantly inhibited Sal-induced increase in mRNA and protein expression of GCLc, SOD1, and SOD2...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233105/salidroside-attenuates-hypoxia-induced-pulmonary-arterial-smooth-muscle-cell-proliferation-and-apoptosis-resistance-by-upregulating-autophagy-through-the-ampk-mtor-ulk1-pathway
#8
Di Gui, Zhimin Cui, Lin Zhang, Chang Yu, Dan Yao, Min Xu, Mayun Chen, Peiliang Wu, Guoping Li, Liangxing Wang, Xiaoying Huang
BACKGROUND: Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have shown that salidroside can exert protective effects against hypoxia-induced pulmonary arterial smooth muscle cell (PASMC) proliferation and apoptosis resistance through the AMPK pathway. This study aims to explore the relationship among AMPK, mTOR and ULK1 in PASMCs under hypoxic conditions and to investigate whether the protective effects of salidroside are related to the autophagic cell death pathway...
December 12, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29228603/elevating-vegf-a-and-pdgf-bb-secretion-by-salidroside-enhances-neoangiogenesis-in-diabetic-hind-limb-ischemia
#9
Agnes Dwi Ariyanti, Julita Sisjayawan, Jing Zhang, Jian-Qi Zhang, Gui-Xue Wang, Makoto Miyagishi, Shou-Rong Wu, Vivi Kasim
Hind-limb ischemia (HLI) is one of the major complication of diabetic patients. Angiogenesis potential in diabetic patients is severely disrupted, and the mechanism underlying it has not been fully elucidated, making it an obstacle for developing an efficient therapeutic angiogenesis strategy. Skeletal muscle cells, through their paracrine function, had been known to be critical for neoangiogenesis. Here we found that hyperglycemia upregulates the expression of skeletal muscle cells prolyl hydroxylase domain 3 (PHD3), which resulted in the decrease of the secretion of angiogenic factors, especially VEGF-A and PDGF-BB...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224349/identification-and-quantification-of-active-components-in-osmanthus-fragrans-fruits-by-hplc-esi-ms-ms
#10
Xiaoyan Liao, Fangli Hu, Zilin Chen
Ripe O. fragrans fruit is composed of purple peels, green pulps and light brown seeds. Since the biological effects such as antioxidative activities and platelet-aggregation inhibition are related to the phenolic compounds and flavonoids in O. fragrans fruits, these components have a great potential as functional food ingredient. In the work, active components in O. fragrans fruits extraction were investigated by HPLC-ESI-MS/MS. A total of twenty-eight compounds were identified and sixteen components were first discovered in O...
December 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29203819/author-correction-mining-of-efficient-microbial-udp-glycosyltransferases-by-motif-evolution-cross-plant-kingdom-for-application-in-biosynthesis-of-salidroside
#11
Bo Fan, Tianyi Chen, Sen Zhang, Bin Wu, Bingfang He
A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198014/inhibition-of-complement-drives-increase-in-early-growth-response-proteins-and-neuroprotection-mediated-by-salidroside-after-cerebral-ischemia
#12
Wenfang Lai, XiuLi Xie, Xiaoqin Zhang, Yingzheng Wang, Kedan Chu, John Brown, Lidian Chen, Guizhu Hong
Salidroside is neuroprotective across a wide therapeutic time-window after cerebral ischemia-reperfusion injury (IRI). Here, we investigated the role of complement in mediating effects of salidroside after cerebral IRI in rats. Rats were administrated with vehicle or salidroside 50 mg/kg, given daily for either 24 or 48 h, after middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for 1 h. Levels of proteins in ischemic brain were measured by immunofluorescence and western blotting. We observed early increases in the deposition of immunoglobulin M, mannose-binding lectin 2, and annexin IV on cerebral endothelial cells, induction of the complement components C3 and C3a, by 24 h after IRI, and a later significant increase in the complement component C1q by 48 h...
December 2, 2017: Inflammation
https://www.readbyqxmd.com/read/29179999/phytochemicals-as-inhibitors-of-nf-%C3%AE%C2%BAb-for-treatment-of-alzheimer-s-disease
#13
REVIEW
Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway...
November 24, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29148269/salidroside-attenuates-neuroinflammation-and-improves-functional-recovery-after-spinal-cord-injury-through-microglia-polarization-regulation
#14
Chenggui Wang, Qingqing Wang, Yiting Lou, Jianxiang Xu, Zhenhua Feng, Yu Chen, Qian Tang, Gang Zheng, Zengjie Zhang, Yaosen Wu, Naifeng Tian, Yifei Zhou, Huazi Xu, Xiaolei Zhang
Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI secondary injury and considered to be the therapeutic target of SCI. Salidroside (Sal) has been reported to exert anti-inflammatory effects in airway, adipose and myocardial tissue; however, the role of Sal in SCI therapeutics has not been clarified. In this study, we showed that Sal could improve the functional recovery of spinal cord in rats as revealed by increased BBB locomotor rating scale, angle of incline, and decreased cavity of spinal cord injury and apoptosis of neurons in vivo...
November 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29115447/salidroside-slows-the-progression-of-ea-hy926-cell-senescence-by-regulating-the-cell-cycle-in-an-atherosclerosis-model
#15
Lin Sun, Fangfang Dou, Jiulin Chen, Huiying Chi, Sanli Xing, Te Liu, Shenwei Sun, Chuan Chen
Aging is the major risk factor for diseases of the cardiovascular system, such as coronary atherosclerotic heart disease, but little is known about the relationship between atherosclerosis (AS) and age‑related declines in vascular structure and function. Here, we used histological analyses in combination with molecular biology techniques to show that lipid deposition in endothelial cell was accompanied by aging and growth arrest. Endothelial cell senescence is sufficient to cause AS; however, we found that salidroside reduced intracellular lipid deposition, slowed the progression of endothelial cell senescence and inhibited the expression of the senescence‑related molecules and phosphorylated the retinoblastoma (Rb) protein...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115408/salidroside-could-enhance-the-cytotoxic-effect-of-l%C3%A2-ohp-on-colorectal-cancer-cells
#16
Xiaoming Shi, Wei Zhao, Yongbin Yang, Shengchun Wu, Bonan Lv
Evidence has suggested that salidroside inhibits the proliferation and invasion of renal clear cell, lung, breast, and colon cancer. However, effect of salidroside on colorectal cancer (CRC) cells against oxaliplatin (L‑OHP) resistance remains unclear. In the present study, the CRC HT‑29 cell line and L‑OHP resistance HT‑29/L‑OHP cell line were used to evaluate the effect, and mechanism of salidroside on L‑OHP resistance. The results demonstrated that the activity of HT‑29 cells was lower compared with that of HT‑29/L‑OHP cells following L‑OHP intervention, and was accompanied with varied expression levels of drug resistant proteins...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29093682/salidroside-a-natural-antioxidant-improves-%C3%AE-cell-survival-and-function-via-activating-ampk-pathway
#17
Linjie Ju, Xiaohua Wen, Chunjun Wang, Yingjie Wei, Yunru Peng, Yongfang Ding, Liang Feng, Luan Shu
Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on β-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased β-cell mass and β-cell replication of diabetic mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29039322/antiviral-activity-of-salidroside-from-the-leaves-of-nigerian-mistletoe-loranthus-micranthus-linn-parasitic-on-hevea-brasiliensis-against-respiratory-syncytial-virus
#18
Matthias Onyebuchi Agbo, Damian Chukwu Odimegwu, Festus Basden Chiedu Okoye, Patience Ogoamaka Osadebe
Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29035891/inhibiting-ros-tfeb-dependent-autophagy-enhances-salidroside-induced-apoptosis-in-human-chondrosarcoma-cells
#19
Wei Zeng, Tao Xiao, Anlie Cai, Weiliang Cai, Huanhuan Liu, Jingling Liu, Jie Li, Miduo Tan, Li Xie, Ying Liu, Xiangcheng Yang, Yi Long
BACKGROUND/AIMS: Autophagy modulation has been considered a potential therapeutic strategy for human chondrosarcoma, and a previous study indicated that salidroside exhibits significant anti-carcinogenic activity. However, the ability of salidroside to induce autophagy and its role in human chondrosarcoma cell death remains unclear. METHODS: We exposed SW1353 cells to different concentrations of salidroside (0.5, 1 and 2 mM) for 24 h. RT-PCR, Western-blotting, Immunocytofluorescence, and Luciferase Reporter Assays were used to evaluate whether salidroside activated the TFEB-dependent autophagy...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29031534/salidroside-alleviates-high-glucose-induced-oxidative-stress-and-extracellular-matrix-accumulation-in-rat-glomerular-mesangial-cells-by-the-txnip-nlrp3-inflammasome-pathway
#20
Shiying Wang, Xinxin Zhao, Suxia Yang, Baoping Chen, Jun Shi
Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major ingredient in Rhodiola rosea and possesses beneficial effects on DN. This study aimed to evaluate the effect of SAL on high glucose (HG)-induced oxidative stress and ECM accumulation and the underlying mechanism. Rat glomerular mesangial cells HBZY-1 were induced by high glucose (HG) in the presence or absence of SAL. Cell proliferation was measured by CCK-8 assay...
October 12, 2017: Chemico-biological Interactions
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