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Salidroside

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https://www.readbyqxmd.com/read/27862112/qualitative-and-quantitative-analysis-of-major-constituents-from-dazhu-hongjingtian-capsule-by-uplc-q-tof-ms-ms-combined-with-uplc-qqq-ms-ms
#1
Guang-Da Liu, Yi-Wu Zhao, Yan-Jing Li, Xue-Jing Wang, Hai-Hong Si, Wen-Zhe Huang, Zhen-Zhong Wang, Shi-Ping Ma, Wei Xiao
In this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major bioactive constituents in Dazhu Hongjingtian capsule by liquid chromatography tandem mass spectrometry (LC-MS). A total of 32 compounds were tentatively identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS/MS). Furthermore, twelve constituents, namely gallic acid, 3,4-dihydroxybenzoic acid, salidroside, p-coumaric acid-4-O-β-D-glucopyranoside, bergeninum, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, syringate, 6''-O-galloylsalidroside, rhodiosin, rhodionin and kaempferol-7-O-α-L-rhamnoside, were simultaneously quantified by the developed ultra-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QQQ-MS/MS) method in 9 min...
November 9, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27848900/antioxidative-effects-of-rhodiola-genus-phytochemistry-and-pharmacological-mechanisms-against-the-diseases
#2
Yongmei Li, Jue Wu, Ruixiu Shi, Na Li, Zhice Xu, Miao Sun
Rhodiola as one of traditional medicines has been used for clinical treatments due to their strong antioxidant properties. Phytochemical analysis revealed the presence of flavonoids, phenylpropanoids, phenylethanol/benzyl alcohol derivatives, cyanogenic glycosides and terpenoids. The bioactive compounds had been demonstrated to be effective at scavenging reactive oxygen species (ROS). The structures contain phenolic hydroxyl groups and unsaturated bonds. This article reviews antioxidant capacities of the extracts and bioactive components derived from Rhodiola plants...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27848074/induction-of-autophagy-by-salidroside-through-the-ampk-mtor-pathway-protects-vascular-endothelial-cells-from-oxidative-stress-induced-apoptosis
#3
Xiang-Tao Zheng, Zi-Heng Wu, Ye Wei, Ju-Ji Dai, Guan-Feng Yu, FengLai Yuan, Le-Chi Ye
Vascular endothelial cells are highly sensitive to oxidative stress, and this is one of the mechanisms by which widespread endothelial dysfunction is induced in most cardiovascular diseases and disorders. However, how these cells can survive in oxidative stress environments remains unclear. Salidroside, a traditional Chinese medicine, has been shown to confer vascular protective effects. We aimed to understand the role of autophagy and its regulatory mechanisms by treating human umbilical vein endothelial cells (HUVECs) with salidroside under oxidative stress...
November 15, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27834881/salidroside-regulates-inflammatory-response-in-raw-264-7-macrophages-via-tlr4-tak1-and-ameliorates-inflammation-in-alcohol-binge-drinking-induced-liver-injury
#4
Peng Sun, Shun-Zong Song, Shuang Jiang, Xia Li, You-Li Yao, Yan-Ling Wu, Li-Hua Lian, Ji-Xing Nan
The current study was designed to investigate the anti-inflammatory effect of salidroside (SDS) and the underlying mechanism by using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro and a mouse model of binge drinking-induced liver injury in vivo. SDS downregulated protein expression of toll-like receptor 4 (TLR4) and CD14. SDS inhibited LPS-triggered phosphorylation of LPS-activated kinase 1 (TAK1), p38, c-Jun terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). Degradation of IκB-α and nuclear translocation of nuclear factor (NF)-κB were effectively blocked by SDS...
November 9, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27809414/salidroside-protects-against-homocysteine-induced-injury-in-huvecs-via-the-regulation-of-endoplasmic-reticulum-stress
#5
Lin Zhu, Fang Jia, Jiang Wei, Yang Yu, Tianhong Yu, Yanjun Wang, Jianhui Sun, Guanghua Luo
INTRODUCTION: Previous studies showed that homocysteine(Hcy) could injure vascular endothelial cells via several mechanisms, including its promotion of oxidative stress pathway and endoplasmic reticulum stress (ER-stress) pathway. Salidroside(SAL) is an active component of Rhodiola rosea with documented antioxidative properties. Emerging evidence conformed that SAL attenuated Hcy induced endothelial dysfunction by reducing oxidative stress. However, its role in ER-stress pathway remains un-clarified...
November 3, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27794583/comparative-study-on-the-protective-effects-of-salidroside-and-hypoxic-preconditioning-for-attenuating-anoxia-induced-apoptosis-in-pheochromocytoma-pc12-cells
#6
Yao Hu, Xiumei Lv, Jing Zhang, Xianli Meng
BACKGROUND Hypoxia is an important sign that can result from body injuries or a special condition such as being at a high altitude or deep water diving. In the current studies, hypoxic preconditioning (HPC) plays a key role in reducing hypoxia-induced apoptosis. We aimed to study the pharmacologic preconditioning effects of salidroside versus those of HPC in hypoxia-/anoxia-induced apoptosis in PC12 cells (pheochromocytoma). MATERIAL AND METHODS PC12 cells were treated by different experimental conditions: control condition, hypoxia condition, HPC condition, low-/middle-/high-dose condition of salidroside, cyclosporine A (CsA), and oratractyloside (ATR)...
October 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27779653/anti-inflammatory-effect-of-salidroside-on-phorbol-12-myristate-13-acetate-plus-a23187-mediated-inflammation-in-hmc-1-cells
#7
Da-Wun Yang, Ok-Hwa Kang, Young-Seob Lee, Sin-Hee Han, Sang-Won Lee, Seon-Woo Cha, Yun-Soo Seo, Su-Hyun Mun, Ryong Gong, Dong-Won Shin, Dong-Yeul Kwon
Salidroside [2-(4-hydroxyphenyl)ethyl β-D-gluco-pyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties. In this study, to ascertain the molecular mechanisms responsible for the anti-inflammatory activity of SAS, we used phorbol-12-myristate-13-acetate (PMA) plus A23187 to induce inflammation in human mast cell line-1 (HMC-1)...
October 18, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27748934/salidroside-induces-apoptosis-and-autophagy-in-human-colorectal-cancer-cells-through-inhibition-of-pi3k-akt-mtor-pathway
#8
Xiang-Jun Fan, Yao Wang, Lei Wang, Mingyan Zhu
The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative properties in human colorectal cancer cells via inducing apoptosis and autophagy. We ascertained that salidroside exerts an inhibitory effect on the proliferation of human colorectal cancer cells in a dose-dependent manner. In addition, salidroside induced cell apoptosis, accompanied by an increase of chromatin condensation and nuclear fragmentation, and a decrease of Bcl-2/Bax protein expression ratio...
September 30, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27738547/neuroprotective-effects-of-salidroside-in-the-mptp-mouse-model-of-parkinson-s-disease-involvement-of-the-pi3k-akt-gsk3%C3%AE-pathway
#9
Wei Zhang, Hong He, Hujie Song, Junjie Zhao, Tao Li, Leitao Wu, Xiaojun Zhang, Jianzong Chen
The degenerative loss through apoptosis of dopaminergic neurons in the substantia nigra pars compacta plays a primary role in the progression of Parkinson's disease (PD). Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3β pathway. The current study aims to increase our understanding of the protective mechanisms of Sal in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine- (MPTP-) induced PD mouse model...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27631782/salidroside-as-a-novel-protective-agent-to-improve-red-blood-cell-cryopreservation
#10
Noha A S Alotaibi, Nigel K H Slater, Hassan Rahmoune
Glycerol and trehalose have been widely examined as protective agents in the cryopreservation of red blood cells (RBCs). However, the effectiveness of these reagents alone on cell viability is moderate. Here, the addition of salidroside attenuated oxidative damage of sheep RBCs prior to and post cryostorage. The supplementation of salidroside to the cryopreservation media containing 10% glycerol improved RBC survival by approximately 61.1±4.8% vs 37.9±4.6%. A smaller effect was seen in RBCs cryopreserved in 300 mM trehalose where the addition of salidroside improved survival by 7...
2016: PloS One
https://www.readbyqxmd.com/read/27627465/salidroside-s-protection-against-uvb-mediated-oxidative-damage-and-apoptosis-is-associated-with-the-upregulation-of-nrf2-expression
#11
Yuan Xiao-Ying, Pang Xiao-Wen, Zhang Guo-Qiang, Guo Jian-You
BACKGROUND: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation. OBJECTIVES: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs. METHODS: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P)H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined...
September 14, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27597978/expression-of-codon-optimized-plant-glycosyltransferase-ugt72b14-in-escherichia-coli-enhances-salidroside-production
#12
Feiyan Xue, Huili Guo, Yingying Hu, Ran Liu, Lina Huang, Heshu Lv, Chunmei Liu, Mingfeng Yang, Lanqing Ma
Salidroside, a plant secondary metabolite in Rhodiola, has been demonstrated to have several adaptogenic properties as a medicinal herb. Due to the limitation of plant source, microbial production of salidroside by expression of plant uridine diphosphate glycosyltransferase (UGT) is promising. However, glycoside production usually remains hampered by poor expression of plant UGTs in microorganisms. Herein, we achieved salidroside production by expression of Rhodiola UGT72B14 in Escherichia coli (E. coli) and codon optimization was accordingly applied...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27581807/salidroside-exhibits-anti-dengue-virus-activity-by-upregulating-host-innate-immune-factors
#13
Navita Sharma, K P Mishra, Lilly Ganju
Dengue is an arboviral disease with no effective therapy available. Therefore, there is an urgent need to find a potent antiviral agent against dengue virus (DENV). In the present study, salidroside, a main bioactive compound of Rhodiola rosea, was evaluated for its antiviral potential against DENV serotype-2 infection and its effect on host innate immune factors. Antiviral effects of salidroside were examined in DENV-infected cells by western blotting, flow cytometry and real-time PCR. Its underlying mechanism involved in antiviral action was determined by evaluating expression of host innate immune factors including RIG-I, IRF-3, IRF-7, PKR, P-eIF2α and NF-κB...
December 2016: Archives of Virology
https://www.readbyqxmd.com/read/27572116/in-vitro-inhibition-of-cytochrome-p-450-activities-and-quantification-of-constituents-in-a-selection-of-commercial-rhodiola-rosea-products
#14
Ole Kristian Thu, Odd Georg Nilsen, Bent Hellum
CONTEXT: Rhodiola rosea L. (Crassulaceae) products are popular natural remedies with a worldwide distribution. Recent studies have revealed potent CYP inhibition by R. rosea extracts both in vitro and in vivo, but information on in vitro CYP inhibition by commercial products are lacking. Variations in commercial R. rosea product quality have also been published. OBJECTIVE: This study evaluates the variation of in vitro CYP inhibition potential and product quality of six commercially available R...
August 29, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27558909/protective-effect-of-salidroside-against-bone-loss-via-hypoxia-inducible-factor-1%C3%AE-pathway-induced-angiogenesis
#15
Ling Li, Ye Qu, Xin Jin, Xiao Qin Guo, Yue Wang, Lin Qi, Jing Yang, Peng Zhang, Ling Zhi Li
Hypoxia-inducible factor (HIF)-1α plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27517893/salidroside-suppresses-huvecs-cell-injury-induced-by-oxidative-stress-through-activating-the-nrf2-signaling-pathway
#16
Yao Zhu, Ya-Jie Zhang, Wei-Wei Liu, Ai-Wu Shi, Ning Gu
Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Salidroside (SAL), one of the main effective constituents of Rhodiola rosea, has been reported to suppress oxidative stress-induced cardiomyocyte injury and necrosis by promoting transcription of nuclear factor E2-related factor 2 (Nrf2)-regulated genes such as heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase (quinone1) (NQO1). However, it has not been indicated whether SAL might ameliorate endothelial injury induced by oxidative stress...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27493875/salidroside-alleviates-cachexia-symptoms-in-mouse-models-of-cancer-cachexia-via-activating-mtor-signalling
#17
Xiangzheng Chen, Yangping Wu, Tinghan Yang, Mingtian Wei, Yuxi Wang, Xiangbing Deng, Congcong Shen, Wenting Li, Hang Zhang, Weiyong Xu, Lantu Gou, Yong Zeng, Yonghui Zhang, Ziqiang Wang, Jinliang Yang
BACKGROUND: Cachexia has a devastating impact on survival and quality of life for many cancer patients and contributes to nearly one-third of all cancer deaths; also, it is associated with poor responses to chemotherapy and survival. A better understanding of the underlying mechanisms of cancer-associated cachexia (CAC), coupled with effective therapeutic approaches, will improve management of progressive functional impairment in cancer patients. Salidroside, a phenylpropanoid glycoside in Rhodiola rosea L, has been reported to possess potential anti-fatigue, anti-ageing, and anti-Alzheimer's disease properties...
May 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27357827/salidroside-protects-cortical-neurons-against-glutamate-induced-cytotoxicity-by-inhibiting-autophagy
#18
Wei-Yong Yin, Qiang Ye, Huan-Jie Huang, Nian-Ge Xia, Yan-Yan Chen, Yi Zhang, Qiu-Min Qu
Recent evidence suggests that glutamate-induced cytotoxicity contributes to autophagic neuron death and is partially mediated by increased oxidative stress. Salidroside has been demonstrated to have neuroprotective effects in glutamate-induced neuronal damage. The precise mechanism of its regulatory role in neuronal autophagy is, however, poorly understood. This study aimed to probe the effects and mechanisms of salidroside in glutamate-induced autophagy activation in cultured rat cortical neurons. Cell viability assay, Western blotting, coimmunoprecipitation, and small interfering RNA were performed to analyze autophagy activities during glutamate-evoked oxidative injury...
August 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27340444/a-selective-and-mild-glycosylation-method-of-natural-phenolic-alcohols
#19
Mária Mastihubová, Monika Poláková
Several bioactive natural p-hydroxyphenylalkyl β-D-glucopyranosides, such as vanillyl β-D-glucopyranoside, salidroside and isoconiferin, and their glycosyl analogues were prepared by a simple reaction sequence. The highly efficient synthetic approach was achieved by utilizing acetylated glycosyl bromides as well as aromatic moieties and mild glycosylation promoters. The aglycones, p-O-acetylated arylalkyl alcohols, were prepared by the reduction of the corresponding acetylated aldehydes or acids. Various stereoselective 1,2-trans-O-glycosylation methods were studied, including the DDQ-iodine or ZnO-ZnCl2 catalyst combination...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27314291/salidroside-reduces-renal-cell-carcinoma-proliferation-by-inhibiting-jak2-stat3-signaling
#20
Cai Lv, Yuan Huang, Zhen-Xiang Liu, Dan Yu, Zhi-Ming Bai
Salidroside has been reported to exhibit anticancer properties. This study aimed to investigate the effects of salidroside on renal cell carcinoma growth. Cell viability and proliferation was assessed by Cell Counting Kit-8 and colony formation assays in A498 and 786-0 cells. The effects of salidroside on in vivo tumor growth were also assessed in a mouse xenograft model of renal cell carcinoma. Flow cytometry was used to analyze cell cycle and apoptosis and protein levels were determined by western blotting...
June 7, 2016: Cancer Biomarkers: Section A of Disease Markers
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