Jianlin Han, Jorge Escorihuela, Santos Fustero, Aitor Landa, Vadim A Soloshonok, Alexander Sorochinsky
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation...
June 13, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry