Omer Bar Ziv, Avivit Cahn, Tallulah Jansen, Valery Istomin, Eynat Kedem, Karen Olshtain-Pops, Sarah Israel, Yonatan Oster, Efrat Orenbuch-Harroch, Maya Korem, Jacob Strahilevitz, Itzchak Levy, Rafael Valdés-Mas, Valeria Ivanova, Eran Elinav, Eduardo Shahar, Hila Elinav
Diabetes is more common among people living with HIV (PLWH), as compared with healthy individuals. In a prospective multicenter study (N = 248), we identified normoglycemic (48.7%), prediabetic (44.4%) and diabetic (6.9%) PLWH. HbA1c and fasting blood glucose (FBG) sensitivity in defining dysglycemia was 96.8%, while addition of oral glucose tolerance test led to reclassification of only 4 patients. Inclusion of 93 additional PLWH with known DM enabled identification of multiple independent predictors of dysglycemia or diabetes: older age, higher BMI, Ethiopian origin, HIV duration, lower integrase inhibitor exposure and advanced disease at diagnosis...
April 1, 2024: Journal of Infectious Diseases