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https://www.readbyqxmd.com/read/28434090/a-best-practice-position-statement-on-the-role-of-the-nephrologist-in-the-prevention-and-follow-up-of-preeclampsia-the-italian-study-group-on-kidney-and-pregnancy
#1
Giorgina Barbara Piccoli, Gianfranca Cabiddu, Santina Castellino, Giuseppe Gernone, Domenico Santoro, Gabriella Moroni, Donatella Spotti, Franca Giacchino, Rossella Attini, Monica Limardo, Stefania Maxia, Antioco Fois, Linda Gammaro, Tullia Todros
Preeclampsia (PE) is a protean syndrome causing a transitory kidney disease, characterised by hypertension and proteinuria, ultimately reversible after delivery. Its prevalence is variously estimated, from 3 to 5% to 10% if all the related disorders, including also pregnancy-induced hypertension (PIH) and HELLP syndrome (haemolysis, increase in liver enzyme, low platelets) are included. Both nephrologists and obstetricians are involved in the management of the disease, according to different protocols, and the clinical management, as well as the role for each specialty, differs worldwide...
April 22, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28433221/c-reactive-protein-predicts-acute-kidney-injury-and-death-after-coronary-artery-bypass-grafting
#2
Seung Seok Han, Dong Ki Kim, Sejoong Kim, Ho Jun Chin, Dong-Wan Chae, Ki Young Na
BACKGROUND: A better prediction of postoperative acute kidney injury (AKI) is worthwhile in patients undergoing coronary artery bypass grafting (CABG) because AKI is associated with high rates of morbidity and mortality. The present study was performed to investigate whether preoperative C-reactive protein (CRP) predicted AKI and the long-term rate of mortality in CABG. METHODS: This retrospective cohort study included 1,656 patients whose high-sensitivity CRPs were measured before CABG at two tertiary referral centers from 2004 to 2010...
April 19, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28432897/hba1c-variability-in-type-2-diabetes-is-associated-with-the-occurrence-of-new-onset-albuminuria-within-three-years
#3
Sreemanee Raaj Dorajoo, Joceline Shi Ling Ng, Jessica Hui Fen Goh, Su Chi Lim, Chun Wei Yap, Alexandre Chan, Joyce Yu Chia Lee
AIMS: To evaluate the association between HbA1c coefficient of variation (HbA1c-CV) and 3-year new-onset albuminuria risk. METHODS: A retrospective cohort study involving 716 normoalbuminuric type 2 diabetes patients was conducted between 2010 and 2014. HbA1c-CV was used to categorize patients into low, moderate or high variability groups. Multivariate logistic models were constructed and validated. Integrated discrimination (IDI) and net reclassification (NRI) improvement indices were used to quantify the added predictive value of HbA1c-CV...
February 14, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28429955/matrix-metalloproteinase-8-and-tissue-inhibitor-of-matrix-metalloproteinase-1-predict-incident-cardiovascular-disease-events-and-all-cause-mortality-in-a-population-based-cohort
#4
Immi Kormi, Mikko T Nieminen, Aki S Havulinna, Tanja Zeller, Stefan Blankenberg, Taina Tervahartiala, Timo Sorsa, Veikko Salomaa, Pirkko J Pussinen
Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations. Design and methods In this prospective cohort study, we investigated the prognostic value of circulating matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-1 concentrations, the ratio of matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 and, for comparison, myeloperoxidase and C-reactive protein concentrations for incident cardiovascular disease endpoints...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28422306/development-of-a-novel-frailty-index-to-predict-mortality-in-patients-with-end-stage-liver-disease
#5
Jennifer C Lai, Kenneth E Covinsky, Jennifer L Dodge, W John Boscardin, Dorry L Segev, John P Roberts, Sandy Feng
BACKGROUND: Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the MELDNa score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in cirrhotics. METHODS: Consecutive outpatients listed for LT at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting due to sickness)...
April 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28419265/validation-of-the-sepsis-metascore-for-diagnosis-of-neonatal-sepsis
#6
Timothy E Sweeney, James L Wynn, María Cernada, Eva Serna, Hector R Wong, Henry V Baker, Máximo Vento, Purvesh Khatri
What’s Known on This Subject.: Neonates are at increased risk for developing sepsis, but this population often exhibits ambiguous clinical signs that complicate the diagnosis of infection. No biomarker has yet shown enough diagnostic accuracy to rule out sepsis at the time of clinical suspicion. What This Study Adds.: We show that a gene-expression-based signature is an accurate objective measure of the risk of sepsis in a neonate or preterm infant, and it substantially improves diagnostic accuracy over that of commonly used laboratory-based testing...
April 13, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28417980/is-active-surveillance-a-suitable-option-for-african-american-men-with-prostate-cancer-a-systemic-literature-review
#7
REVIEW
M I Gökce, D Sundi, E Schaeffer, C Pettaway
BACKGROUND: Certain patients presenting with either low or very-low-risk prostate cancer (PCa) can represent a therapeutic dilemma for physicians. The oncologic outcomes of active surveillance (AS) for men with very-low-risk PCa are overall excellent. However, there are concerns about AS related to the potential for upgrading or upstaging. The African American (AA) population is under-represented in studies evaluating AS outcomes and this is particularly important because of the unique epidemiology of PCa in AA men...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28417979/longitudinal-assessment-of-urinary-pca3-for-predicting-prostate-cancer-grade-reclassification-in-favorable-risk-men-during-active-surveillance
#8
J J Tosoian, H D Patel, M Mamawala, P Landis, S Wolf, D J Elliott, J I Epstein, H B Carter, A E Ross, L J Sokoll, C P Pavlovich
BACKGROUND: To assess the utility of urinary prostate cancer antigen 3 (PCA3) as both a one-time and longitudinal measure in men on active surveillance (AS). METHODS: The Johns Hopkins AS program monitors men with favorable-risk prostate cancer with serial PSA, digital rectal examination (DRE), prostate magnetic resonance imaging and prostate biopsy. Since 2007, post-DRE urinary specimens have also been routinely obtained. Men with multiple PCA3 measures obtained over ⩾3 years of monitoring were included...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28416200/comparison-of-qrs-duration-and-associated-cardiovascular-events-in-american-indian-men-versus-women-the-strong-heart-study
#9
Jason F Deen, Dorothy A Rhoades, Carolyn Noonan, Lyle G Best, Peter M Okin, Richard B Devereux, Jason G Umans
Electrocardiographic QRS duration at rest is associated with sudden cardiac death and death from coronary heart disease in the general population. However, its relation to cardiovascular events in American Indians, a population with persistently high cardiovascular disease mortality, is unknown. The relation of QRS duration to incident cardiovascular disease during 17.2 years of follow-up was assessed in 1,851 male and female Strong Heart Study participants aged 45 to 74 years without known cardiovascular disease at baseline...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28415034/validation-of-a-new-mortality-risk-prediction-model-for-people-65-years-and-older-in-northwest-russia-the-crystal-risk-score
#10
Anna Turusheva, Elena Frolova, Vaes Bert, Eralda Hegendoerfer, Jean-Marie Degryse
BACKGROUND: Prediction models help to make decisions about further management in clinical practice. This study aims to develop a mortality risk score based on previously identified risk predictors and to perform internal and external validations. METHODS: In a population-based prospective cohort study of 611 community-dwelling individuals aged 65+ in St. Petersburg (Russia), all-cause mortality risks over 2.5 years follow-up were determined based on the results obtained from anthropometry, medical history, physical performance tests, spirometry and laboratory tests...
March 29, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28411288/predicting-30-day-pneumonia-readmissions-using-electronic-health-record-data
#11
Anil N Makam, Oanh Kieu Nguyen, Christopher Clark, Song Zhang, Bin Xie, Mark Weinreich, Eric M Mortensen, Ethan A Halm
BACKGROUND: Readmissions after hospitalization for pneumonia are common, but the few risk-prediction models have poor to modest predictive ability. Data routinely collected in the electronic health record (EHR) may improve prediction. OBJECTIVE: To develop pneumonia-specific readmission risk-prediction models using EHR data from the first day and from the entire hospital stay ("full stay"). DESIGN: Observational cohort study using stepwise-backward selection and cross-validation...
April 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28410581/statistical-evaluation-of-adding-multiple-risk-factors-improves-framingham-stroke-risk-score
#12
Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu, Jiayin Zheng
BACKGROUND: Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual's absolute risk on stroke onset. However, several widely accepted risk factors for stroke were not included in the original Framingham model. This study proposed a new model which combines an existing risk models with new risk factors using synthesis analysis, and applied it to the longitudinal Atherosclerosis Risk in Communities (ARIC) data set. METHODS: Risk factors in original prediction models and new risk factors in proposed model had been discussed...
April 14, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28398455/systematic-evaluation-of-endothelin-1-measurement-relative-to-traditional-and-modern-biomarkers-for-clinical-assessment-and-prognosis-in-patients-with-chronic-systolic-heart-failure-serial-measurement-and-multimarker-testing
#13
Hanna K Gaggin, Quynh A Truong, Parul U Gandhi, Shweta R Motiwala, Arianna M Belcher, Rory B Weiner, Aaron L Baggish, James L Januzzi
Objectives: To define the role of single or serial measurement of endothelin 1 (ET-1) for prognostication beyond traditional and modern markers of risk in heart failure (HF). Methods: In total, 115 patients with chronic systolic HF were followed for 10 months. Clinical assessment and ET-1, N-terminal pro-B-type natriuretic peptide (NT-proBNP), highly sensitive troponin I (hsTnI), soluble ST2 (sST2), and galectin 3 were measured at each visit. Results: Elevated ET-1 was associated with worse HF, lower right ventricular function, higher pulmonary pressure, and higher left atrial volume index despite similar left ventricular function...
April 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28393349/multiple-biomarkers-improve-the-prediction-of-multiple-sclerosis-in-clinically-isolated-syndromes
#14
V Martinelli, G Dalla Costa, M J Messina, G Di Maggio, F Sangalli, L Moiola, M Rodegher, B Colombo, R Furlan, L Leocani, A Falini, G Comi
OBJECTIVES: Since its introduction, MRI had a major impact on the early and more precise diagnosis of multiple sclerosis (MS), and the 2010 diagnostic criteria even allow a diagnosis to be made just after a single attack if stringent MRI criteria are met. Several other clinical and paraclinical markers have been reported to be associated with an increased risk of MS independently of MRI in patients with clinically isolated syndromes (CIS), but the incremental usefulness of adding them to the current criteria has not been evaluated...
April 9, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28389067/prognostic-value-of-geriatric-conditions-beyond-age-after-acute-coronary-syndrome
#15
Juan Sanchis, Vicente Ruiz, Clara Bonanad, Ernesto Valero, Maria Arantzazu Ruescas-Nicolau, Yasmin Ezzatvar, Clara Sastre, Sergio García-Blas, Anna Mollar, Vicente Bertomeu-González, Gema Miñana, Julio Núñez
The aim of the present study was to investigate the prognostic value of geriatric conditions beyond age after acute coronary syndrome. This was a prospective cohort design including 342 patients (from October 1, 2010, to February 1, 2012) hospitalized for acute coronary syndrome, older than 65 years, in whom 5 geriatric conditions were evaluated at discharge: frailty (Fried and Green scales), comorbidity (Charlson and simple comorbidity indexes), cognitive impairment (Pfeiffer test), physical disability (Barthel index), and instrumental disability (Lawton-Brody scale)...
April 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28386716/importance-of-variants-in-cerebrovascular-anatomy-for-potential-retrograde-embolization-in-cryptogenic-stroke
#16
Michael Markl, Edouard Semaan, LeRoy Stromberg, James Carr, Shyam Prabhakaran, Jeremy Collins
OBJECTIVES: To test the hypothesis that variants in cerebrovascular anatomy will affect the number of patients demonstrating a plausible retrograde embolization mechanism from plaques in the descending aorta (DAo). METHODS: Thirty-five patients (aged 63 ± 17 years) with cryptogenic stroke underwent 4D flow MRI for the assessment of aortic 3D blood flow and MR angiography for the evaluation of circle of Willis, posterior circulation, and aortic arch architecture...
April 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28381400/association-of-plasma-7-ketocholesterol-with-cardiovascular-outcomes-and-total-mortality-in-patients-with-coronary-artery-disease
#17
Jiayi Song, Duan Wang, Hongen Chen, Xiuwei Huang, Yuan Zhong, Nan Jiang, Chaogang Chen, Min Xia
Rationale: 7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. Objective: We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease (CAD). Methods and Results: We measured the plasma 7-KC levels by high performance liquid chromatography in a prospective cohort study of 1016 patients (mean age 63.2 years, male 61.1%) with stable CAD who were recruited from December 2008 to December 2011, and followed up for a median of 4...
April 5, 2017: Circulation Research
https://www.readbyqxmd.com/read/28379333/comparison-of-coronary-artery-calcification-carotid-intima-media-thickness-and-ankle-brachial-index-for-predicting-10-year-incident-cardiovascular-events-in-the-general-population
#18
Marie Henrike Geisel, Marcus Bauer, Frauke Hennig, Barbara Hoffmann, Nils Lehmann, Stefan Möhlenkamp, Knut Kröger, Kaffer Kara, Tobias Müller, Susanne Moebus, Raimund Erbel, André Scherag, Karl-Heinz Jöckel, Amir A Mahabadi
Aims: To compare the predictive value of coronary artery calcification (CAC), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) in a primary prevention cohort depending on risk factor profile to determine which of the three markers improves cardiovascular (CV) risk discrimination best in which risk group. Methods and results: We quantified CAC, CIMT, and ABI in 3108 subjects (mean age 59.2 ± 7.7, 47.1% male) without prevalent CV diseases from the population-based Heinz Nixdorf Recall study...
March 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28369481/identification-of-vascular-patients-at-very-high-risk-for-recurrent-cardiovascular-events-validation-of-the-current-acc-aha-very-high-risk-criteria
#19
M Johanneke van den Berg, Deepak L Bhatt, L Jaap Kappelle, Gert J de Borst, Maarten J Cramer, Yolanda van der Graaf, Ph Gabriel Steg, Frank L J Visseren
Aims: To validate and assess performance of the current ACC/AHA very high risk criteria in patients with clinically manifest arterial disease. Methods and results: Data were used from the SMART study (n = 7216) and REACH Registry (n = 48 322), two prospective cohorts of patients with manifest atherosclerotic arterial disease. Prevalence and incidence rates of recurrent major adverse cardiovascular events (MACE) were calculated, according to the ACC/AHA VHR criteria (cardiovascular disease combined with diabetes, smoking, dyslipidaemia, and/or recent recurrent coronary events)...
March 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28369148/right-atrial-volume-by-cardiovascular-magnetic-resonance-predicts-mortality-in-patients-with-heart-failure-with-reduced-ejection-fraction
#20
Alexander Ivanov, Ambreen Mohamed, Ahmed Asfour, Jean Ho, Saadat A Khan, Onn Chen, Igor Klem, Kumudha Ramasubbu, Sorin J Brener, John F Heitner
BACKGROUND: Right Atrial Volume Index (RAVI) measured by echocardiography is an independent predictor of morbidity in patients with heart failure (HF) with reduced ejection fraction (HFrEF). The aim of this study is to evaluate the predictive value of RAVI assessed by cardiac magnetic resonance (CMR) for all-cause mortality in patients with HFrEF and to assess its additive contribution to the validated Meta-Analysis Global Group in Chronic heart failure (MAGGIC) score. METHODS AND RESULTS: We identified 243 patients (mean age 60 ± 15; 33% women) with left ventricular ejection fraction (LVEF) ≤ 35% measured by CMR...
2017: PloS One
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