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Risk Reclassification

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https://www.readbyqxmd.com/read/28738057/the-fatty-liver-index-as-a-predictor-of-incident-chronic-kidney-disease-in-a-10-year-prospective-cohort-study
#1
Ji Hye Huh, Jang Young Kim, Eunhee Choi, Jae Seok Kim, Yoosoo Chang, Ki-Chul Sung
BACKGROUND: Although non-alcoholic fatty liver disease (NAFLD) is considered to be associated with chronic kidney disease (CKD), long-term follow up data is lacking. We investigated whether NAFLD, as determined by the fatty liver index (FLI), could predict incident CKD in 10-year prospective cohort study. We also assessed the clinical utility of FLI to predict the development of CKD. METHODS: 6,238 adults aged 40 to 69 years without baseline CKD from the Ansan-Ansung cohort were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28735781/the-future-of-fracture-risk-assessment-in-the-management-of-osteoporosis
#2
Sanford Baim
There have been many advances in the field of osteoporosis that add to a greater understanding of skeletal integrity and the adverse effects menopause and aging have on bone. The World Health Organization, the International Osteoporosis Foundation, and numerous additional governmental and privately sponsored organizations, societies, and their respective task forces have provided guidance for the use of appropriate fracture assessment methodologies and fracture risk assessment tools, and for the prevention and management of osteoporosis...
July 20, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28733174/lipoprotein-insulin-resistance-score-and-risk-of-incident-diabetes-during-extended-follow-up-of-20%C3%A2-years-the-women-s-health-study
#3
Paulo H N Harada, Olga V Demler, Sagar B Dugani, Akintunde O Akinkuolie, Manickavasagar V Moorthy, Paul M Ridker, Nancy R Cook, Aruna D Pradhan, Samia Mora
BACKGROUND: Type II diabetes (T2D) is preceded by prolonged insulin resistance and relative insulin deficiency incompletely captured by glucose metabolism parameters, high-density lipoprotein (HDL) cholesterol and triglycerides. OBJECTIVE: Whether lipoprotein insulin resistance (LPIR) score, a metabolomic marker, is associated with incident diabetes and improves risk reclassification over traditional markers on extended follow-up. METHODS: Among 25,925 nondiabetic women aged 45 years or older, LPIR was measured by nuclear magnetic resonance spectroscopy as a weighted score of very low density lipoprotein, low-density lipoprotein, and HDL particle sizes, and their subsets concentrations...
June 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28729407/long-term-stroke-risk-prediction-in-patients-with-atrial-fibrillation-comparison-of-the-abc-stroke-and-cha2ds2-vasc-scores
#4
José Miguel Rivera-Caravaca, Vanessa Roldán, María Asunción Esteve-Pastor, Mariano Valdés, Vicente Vicente, Gregory Y H Lip, Francisco Marín
BACKGROUND: The ABC-stroke score (age, biomarkers [N-terminal fragment B-type natriuretic peptide, high-sensitivity troponin], and clinical history [prior stroke/transient ischemic attack]) was proposed to predict stroke in atrial fibrillation (AF). This score was derived/validated in 2 clinical trial cohorts in which patients with AF were highly selected and carefully followed-up. However, the median follow-up was 1.9 years in the trial cohort; therefore, its long-term predictive performance remains uncertain...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28729345/recent-advances-in-understanding-and-managing-body-dysmorphic-disorder
#5
REVIEW
Georgina Krebs, Lorena Fernández de la Cruz, David Mataix-Cols
Body dysmorphic disorder (BDD) is a relatively common and disabling psychiatric disorder characterised by excessive and persistent preoccupation with perceived defects or flaws in one's appearance, which are unnoticeable to others, and associated repetitive behaviours (eg, mirror checking). The disorder generally starts in adolescence, but often goes unnoticed and is severely underdiagnosed. Left untreated, BDD typically persists and causes marked functional impairment in multiple domains. This clinical review considers recent advances in the epidemiology and classification of BDD, including its reclassification in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders under the new 'Obsessive-Compulsive and Related Disorders' chapter...
July 20, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28729251/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#6
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loic Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazard model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28728851/predictors-of-incident-heart-failure-in-patients-after-an-acute-coronary-syndrome-the-lipid-heart-failure-risk-prediction-model
#7
Andrea Driscoll, Elizabeth H Barnes, Stefan Blankenberg, David M Colquhoun, David Hunt, Paul J Nestel, Ralph A Stewart, Malcolm J West, Harvey D White, John Simes, Andrew Tonkin
BACKGROUND: Coronary heart disease is a major cause of heart failure. Availability of risk-prediction models that include both clinical parameters and biomarkers is limited. We aimed to develop such a model for prediction of incident heart failure. METHODS: A multivariable risk-factor model was developed for prediction of first occurrence of heart failure death or hospitalization. A simplified risk score was derived that enabled subjects to be grouped into categories of 5-year risk varying from <5% to >20%...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28724664/biochemical-molecular-and-clinical-characterization-of-succinate-dehydrogenase-subunit-a-variants-of-unknown-significance
#8
Amber E Bannon, Jason D Kent, Isaac Forquer, Ajia Town, Lillian R Klug, Kelly E McCann, Carol Beadling, Olivier Harismendy, Jason K Sicklick, Christopher L Corless, Ujwal Shinde, Michael C Heinrich
Patients who inherit a pathogenic loss-of-function genetic variant involving one of the four succinate dehydrogenase (SDH) subunit genes have up to an 86% chance of developing one or more cancers by the age of 50. If tumors are identified and removed early in these high-risk patients, they have a higher potential for cure.  Unfortunately, many alterations identified in these genes are variants of unknown significance (VUS), confounding the identification of high-risk patients. If we could identify misclassified SDH VUS as benign or pathogenic SDH mutations, we could better select patients for cancer screening procedures and remove tumors at earlier stages...
July 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28719899/the-relationship-between-mmp-2-1306c-t-and-mmp-9-1562c-t-polymorphisms-and-the-risk-and-prognosis-of-t-cell-acute-lymphoblastic-leukemia-in-a-chinese-population-a-case-control-study
#9
Cong-Meng Lin, Yan-Ling Zeng, Min Xiao, Xu-Qiao Mei, Lv-Ying Shen, Meng-Xian Guo, Zhe-Yao Lin, Qi-Fa Liu, Tin Yang
BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease and is often accompanied by a variety of genetic abnormalities. Hence, our study aims to investigate the relationship between MMP-2 -1306C>T and MMP-9 -1562C>T polymorphisms and the risk and prognosis of T-ALL. METHODS: From April 2009 to February 2011, a total of 376 T-ALL patients were chosen as the case group. Meanwhile, 352 healthy people who passed routine health examinations were selected as the control group...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28710901/baseline-and-longitudinal-plasma-caveolin-1-level-as-a-biomarker-in-active-surveillance-for-early-stage-prostate-cancer
#10
Spyridon P Basourakos, John W Davis, Brian F Chapin, John F Ward, Curtis A Pettaway, Louis L Pisters, Neema Navai, Mary F Achim, Xuemei Wang, Hsiang-Chun Chen, Seungtaek Choi, Deborah Kuban, Patricia Troncoso, Sam Hanash, Timothy C Thompson, Jeri Kim
OBJECTIVES: To evaluate the role of caveolin-1 as a predictor of disease reclassification in men with early prostate cancer undergoing active surveillance. PATIENTS AND METHODS: We analyzed archived plasma samples prospectively collected from men with early prostate cancer in a single-institution active surveillance study. Of 825 patients enrolled, 542 had 1 or more years of follow-up. Baseline and longitudinal plasma caveolin-1 levels were measured using an enzyme-linked immunosorbent assay...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28708570/serum-omentin-1-is-a-novel-biomarker-for-predicting-the-functional-outcome-of-acute-ischemic-stroke-patients
#11
Tian Xu, Peng Zuo, Yuqin Wang, Zhiwei Gao, Kaifu Ke
BACKGROUND: Recent studies have suggested that omentin-1 plays a critical role in the development of cardiovascular disease. However, reported findings are inconsistent, and no study has evaluated the association between omentin-1 levels and a poor functional outcome after ischemic stroke onset. METHODS: A total of 266 acute ischemic stroke patients were included in this study. All patients were prospectively followed up for 3 months after acute ischemic stroke onset and a poor functional outcome was defined as a major disability or death occurring during the follow-up period...
July 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28704383/predicting-in-hospital-death-during-acute-presentation-with-pulmonary-embolism-to-facilitate-early-discharge-and-outpatient-management
#12
Jerrett K Lau, Vincent Chow, Alex Brown, Leonard Kritharides, Austin C C Ng
BACKGROUND: Pulmonary embolism continues to be a significant cause of death. The aim was to derive and validate a risk prediction model for in-hospital death after acute pulmonary embolism to identify low risk patients suitable for outpatient management. METHODS: A confirmed acute pulmonary embolism database of 1,426 consecutive patients admitted to a tertiary-center (2000-2012) was analyzed, with odd and even years as derivation and validation cohorts respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28699974/cardiovascular-risk-stratification-and-statin-eligibility-based-on-the-brazilian-vs-north-american-guidelines-on-blood-cholesterol-management
#13
Fernando Henpin Yue Cesena, Antonio Gabriele Laurinavicius, Viviane A Valente, Raquel D Conceição, Raul D Santos, Marcio S Bittencourt
Background: The best way to select individuals for lipid-lowering treatment in the population is controversial. Objective: In healthy individuals in primary prevention: to assess the relationship between cardiovascular risk categorized according to the V Brazilian Guideline on Dyslipidemia and the risk calculated by the pooled cohort equations (PCE); to compare the proportion of individuals eligible for statins, according to different criteria. Methods: In individuals aged 40-75 years consecutively submitted to routine health assessment at one single center, four criteria of eligibility for statin were defined: BR-1, BR-2 (LDL-c above or at least 30 mg/dL above the goal recommended by the Brazilian Guideline, respectively), USA-1 and USA-2 (10-year risk estimated by the PCE ≥ 5...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28698269/urinary-matrix-metalloproteinase-7-predicts-severe-aki-and-poor-outcomes-after-cardiac-surgery
#14
Xiaobing Yang, Chunbo Chen, Siyuan Teng, Xiaorui Fu, Yan Zha, Huafeng Liu, Li Wang, Jianwei Tian, Xiangyan Zhang, Youhua Liu, Jing Nie, Fan Fan Hou
Urinary matrix metalloproteinase-7 (uMMP-7) levels consistently reflect the activity of intrarenal Wnt/β-catenin, which is activated in AKI models. To test the hypothesis that uMMP-7 is a predictor for severe AKI in patients after cardiac surgery, we performed a prospective, multicenter, two-stage cohort study in 721 patients undergoing cardiac surgery. In stage 1, we enrolled 323 children from three academic medical centers. In stage 2, we enrolled 398 adults at six centers. We analyzed levels of uMMP-7 and other injury biomarkers during the perioperative period...
July 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28688158/determination-of-hepatocellular-carcinoma-grade-by-needle-biopsy-is-unreliable-for-liver-transplant-candidate-selection
#15
Colin M Court, Michael P Harlander-Locke, Daniela Markovic, Samuel W French, Bita V Naini, David S Lu, Steven S Raman, Fady M Kaldas, Ali Zarrinpar, Douglas G Farmer, Richard S Finn, Saeed Sadeghi, James S Tomlinson, Ronald W Busuttil, Vatche G Agopian
OBJECTIVE: To evaluate the utility of preoperative needle biopsy (PNB) grading of hepatocellular carcinoma (HCC) as a biomarker for liver transplant (LT) candidate selection. BACKGROUND: Given the prognostic significance of HCC tumor grade, PNB grading has been proposed as a biomarker for LT candidate selection. METHODS: Clinicopathologic characteristics of HCC LT recipients (1989-2014) with a PNB were analyzed, and concordance of PNB grade to explant grade and vascular invasion was assessed to determine whether incorporation of PNB grade to accepted transplant criteria improved candidate selection...
July 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28684396/cardiac-stress-and-inflammatory-markers-as-predictors-of-heart-failure-in-patients-with-type-2-diabetes-the-advance-trial
#16
Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers
OBJECTIVE: This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A nested case-cohort study was conducted in 3,098 participants with type 2 diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial...
July 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28683900/derivation-and-validation-of-a-novel-prediction-model-to-identify-low-risk-patients-with-acute-pulmonary-embolism
#17
Muthiah Subramanian, Sowmya Gopalan, Srinivasan Ramadurai, Preetam Arthur, Mukund A Prabhu, Rajesh Thachathodiyl, Kumaraswamy Natarajan
Accurate identification of low-risk patients with acute pulmonary embolism (PE) who may be eligible for outpatient treatment or early discharge can have substantial cost-saving benefit. The purpose of this study was to derive and validate a prediction model to effectively identify patients with PE at low risk of short-term mortality, right ventricular dysfunction, and other nonfatal outcomes. This study analyzed data from 400 consecutive patients with acute PE. We derived and internally validated our prediction rule based on clinically significant variables that are routinely available at initial examination and that were categorized and weighted using coefficients in the multivariate logistic regression...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hgf-and-plgf-predict-mortality-in-a-general-population-a-prospective-cohort-study
#18
Kristiina Santalahti, Aki Havulinna, Mikael Maksimow, Tanja Zeller, Stefan Blankenberg, Aki Vehtari, Heikki Joensuu, Sirpa Jalkanen, Veikko Salomaa, Marko Salmi
BACKGROUND: Circulating levels of growth factors involved in leukocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N=8444, aged 25-74; 2002 Replication cohort, N=2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
July 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28680124/refining-long-term-prediction-of-cardiovascular-risk-in-diabetes-the-vildia-score
#19
Georg Goliasch, Günther Silbernagel, Marcus E Kleber, Tanja B Grammer, Stefan Pilz, Andreas Tomaschitz, Philipp E Bartko, Gerald Maurer, Wolfgang Koenig, Alexander Niessner, Winfried März
Cardiovascular risk assessment in patients with diabetes relies on traditional risk factors. However, numerous novel biomarkers have been found to be independent predictors of cardiovascular disease, which might significantly improve risk prediction in diabetic patients. We aimed to improve prediction of cardiovascular risk in diabetic patients by investigating 135 evolving biomarkers. Based on selected biomarkers a clinically applicable prediction algorithm for long-term cardiovascular mortality was designed...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674420/improved-risk-stratification-in-prevention-by-use-of-a-panel-of-selected-circulating-micrornas
#20
Till Keller, Jes-Niels Boeckel, Stefan Groß, Jens Klotsche, Lars Palapies, David Leistner, Lars Pieper, Günnter K Stalla, Hendrik Lehnert, Sigmund Silber, David Pittrow, Winfried Maerz, Marcus Dörr, Hans-Ulrich Wittchen, Sebastian E Baumeister, Uwe Völker, Stephan B Felix, Stefanie Dimmeler, Andreas M Zeiher
Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 and miR-133 were determined from peripheral blood by qPCR and combined to a risk panel. As derivation cohort, 178 individuals of the DETECT study, and as validation cohort, 129 individuals of the SHIP study were used in a case-control approach...
July 3, 2017: Scientific Reports
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