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Risk Reclassification

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https://www.readbyqxmd.com/read/29688131/taxonomic-repositioning-of-xanthomonas-campestris-pv-viticola-nayudu-1972-dye-1978-as-xanthomonas-citri-pv-viticola-nayudu-1972-dye-1978-comb-nov-and-emendation-of-the-description-of-xanthomonas-citri-pv-anacardii-to-include-pigmented-isolates-pathogenic-to
#1
Marco Aurélio Siqueira Gama, Rosa Ramos Mariano, Wilson José Silva Júnior, Antônio Roberto Gomes Farias, Maria Angélica Guimarães Barbosa, Marisa A S V Ferreira, César Raimundo Lima Costa Júnior, Liliana A Santos, Elineide B Souza
Grapevine bacterial canker, which is caused by Xanthomonas campestris pv. viticola, is one of the most important grapevine diseases in the northeastern region of Brazil. This disease causes severe damage and represents a high potential risk to the development of Brazilian viticulture. In turn, pigmented isolates pathogenic to cashew plant, making cashew fruit unfit for sale, also have been detected in Northeastern Brazil. Given that the taxonomic position of these bacteria is unclear, the multilocus sequence analysis (MLSA) technique, average nucleotide identity (ANI) values and tetranucleotide frequency correlation coefficients (TETRA) were used to analyze their phylogenetic relationship in relation to other Xanthomonas species...
April 24, 2018: Phytopathology
https://www.readbyqxmd.com/read/29685497/plasma-biomarkers-are-associated-with-renal-outcomes-in-individuals-with-apol1-risk-variants
#2
Girish N Nadkarni, Kinsuk Chauhan, Divya A Verghese, Chirag R Parikh, Ron Do, Carol R Horowitz, Erwin P Bottinger, Steven G Coca
G1/G2 variants in the Apolipoprotein L1 (APOL1) gene are associated with end-stage renal disease (ESRD) in people with African ancestry. Plasma biomarkers may have utility for risk stratification in APOL1 high-risk individuals of African ancestry. To evaluate this, we measured tumor necrosis factor receptor 1/2 (TNFR1/2) and kidney injury molecule-1 (KIM1) in baseline plasma specimens from individuals of African ancestry with high-risk APOL1 genotype. Biomarker association with a composite renal outcome of ESRD or 40% sustained decline in estimated glomerular filtration rate (eGFR) was then determined and then assessed as improvement in area under curve...
April 20, 2018: Kidney International
https://www.readbyqxmd.com/read/29681522/epidemiologic-observations-guiding-clinical-application-of-a-urinary-peptidomic-marker-of-diastolic-left-ventricular-dysfunction
#3
Zhen-Yu Zhang, Esther Nkuipou-Kenfack, Wen-Yi Yang, Fang-Fei Wei, Nicholas Cauwenberghs, Lutgarde Thijs, Qi-Fang Huang, Ying-Mei Feng, Joost P Schanstra, Tatiana Kuznetsova, Jens-Uwe Voigt, Peter Verhamme, Harald Mischak, Jan A Staessen
Hypertension, obesity, and old age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools for people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, can predict over a 5-year time span mildly impaired diastolic LV function as assessed by echocardiography. In 645 white Flemish (50.5% women; 50.9 years [mean]), we measured HF1 by capillary electrophoresis coupled with mass spectrometry in 2005-2010. We measured early (E) and late (A) peak velocities of the transmitral blood flow and early (e') and late (a') mitral annular peak velocities and their ratios in 2009-2013...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29680338/a-comparison-of-the-updated-diamond-forrester-cad-consortium-and-confirm-history-based-risk-scores-for-predicting-obstructive-coronary-artery-disease-in-patients-with-stable-chest-pain-the-scot-heart-coronary-cta-cohort
#4
Lohendran Baskaran, Ibrahim Danad, Heidi Gransar, Bríain Ó Hartaigh, Joshua Schulman-Marcus, Fay Y Lin, Jessica M Peña, Amanda Hunter, David E Newby, Philip D Adamson, James K Min
OBJECTIVES: This study sought to compare the performance of history-based risk scores in predicting obstructive coronary artery disease (CAD) among patients with stable chest pain from the SCOT-HEART study. BACKGROUND: Risk scores for estimating pre-test probability of CAD are derived from referral-based populations with a high prevalence of disease. The generalizability of these scores to lower prevalence populations in the initial patient encounter for chest pain is uncertain...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#5
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29668649/examining-parental-medication-adherence-as-a-predictor-of-child-medication-adherence-in-pediatric-anxiety-disorders
#6
Greta A Bushnell, M Alan Brookhart, Bradley N Gaynes, Scott N Compton, Stacie B Dusetzina, Til Stürmer
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the recommended first-line pharmacotherapy for pediatric anxiety disorders but adherence remains difficult to predict. OBJECTIVES: To estimate SSRI adherence in children with anxiety disorders and determine if prior parental medication adherence is predictive of child high SSRI adherence. METHODS: We identified children (3-17 y) initiating SSRI treatment after an anxiety disorder diagnosis in a commercial claims database (2005-2014)...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29667200/treatment-in-a-preventive-cardiology-clinic-utilizing-advanced-practice-providers-apps-effectively-closes-atherosclerotic-cardiovascular-disease-ascvd-risk-management-gaps-amongst-a-primary-prevention-population-compared-with-a-propensity-matched-primary-care
#7
Emilio Fentanes, Anthony G Vande Hei, R Scott Holuby, Norma Suarez, Yousif Slim, Jennifer N Slim, Ahmad M Slim, Dustin Thomas
BACKGROUND: Advanced Practice Providers (APPs) can fill access to care gaps created by physician shortages and improve adherence/compliance with preventive atherosclerotic cardiovascular disease (ASCVD) interventions. METHODS: We retrospectively reviewed data on 595 patients enrolled in a preventive cardiology clinic (PCC) utilizing APPs compared with a propensity-matched cohort (PMC) of 595 patients enrolled in primary care clinics alone. PCC patients were risk stratified using Framingham risk scoring (FRS) and coronary artery calcium scoring (CACS) and treated based on published guideline-based algorithms...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29666065/predicting-30-day-hospital-readmissions-in-acute-myocardial-infarction-the-ami-readmits-renal-function-elevated-brain-natriuretic-peptide-age-diabetes-mellitus-nonmale-sex-intervention-with-timely-percutaneous-coronary-intervention-and-low-systolic-blood-pressure
#8
Oanh Kieu Nguyen, Anil N Makam, Christopher Clark, Song Zhang, Sandeep R Das, Ethan A Halm
BACKGROUND: Readmissions after hospitalization for acute myocardial infarction (AMI) are common. However, the few currently available AMI readmission risk prediction models have poor-to-modest predictive ability and are not readily actionable in real time. We sought to develop an actionable and accurate AMI readmission risk prediction model to identify high-risk patients as early as possible during hospitalization. METHODS AND RESULTS: We used electronic health record data from consecutive AMI hospitalizations from 6 hospitals in north Texas from 2009 to 2010 to derive and validate models predicting all-cause nonelective 30-day readmissions, using stepwise backward selection and 5-fold cross-validation...
April 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29660351/association-of-low-hemoglobin-with-symptomatic-venous-thromboembolism-in-acutely-ill-hospitalized-medical-patients-an-apex-trial-substudy
#9
Gerald Chi, C Michael Gibson, Adrian F Hernandez, Russell D Hull, Syed Hassan A Kazmi, Ahmed Younes, Sargun S Walia, Anmol Pitliya, Amandeep Singh, Farima Kahe, Arzu Kalayci, Tarek Nafee, Mathieu Kerneis, Fahad AlKhalfan, Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber
BACKGROUND: Anemia is a common finding and independent predictor for adverse outcomes in hospitalized patients with medical illness. It remains unclear whether anemia is a risk factor for venous thromboembolism and whether the presence of anemia can refine risk assessment for prediction of venous thromboembolism, thereby adding incremental utility to a validated model. METHODS: In the APEX trial, 7,513 hospitalized medical patients were randomized to receive either betrixaban or standard-of-care enoxaparin for thromboprophylaxis...
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29659657/prognostic-value-of-electrocardiographic-left-ventricular-hypertrophy-on-cardiovascular-risk-in-a-non-hypertensive-community-based-population
#10
Kentaro Tanaka, Fumitaka Tanaka, Toshiyuki Onoda, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Shinichi Omama, Kuniaki Ogasawara, Yasuhiro Ishibashi, Kazuyoshi Itai, Toru Kuribayashi, Akira Okayama, Motoyuki Nakamura
BACKGROUND: The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals. METHODS: A total of 4,927 non-hypertensive individuals ≥ 40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP)...
April 6, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29657049/prognostic-implication-of-thermodilution-coronary-flow-reserve-in-patients-with-indeterminate-pressure-bounded-coronary-flow-reserve
#11
Joo Myung Lee, Tae-Min Rhee, Doyeon Hwang, Jonghanne Park, Chee Hae Kim, Ki Hong Choi, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bon-Kwon Koo
BACKGROUND: Recently, the concept of pressure-bounded coronary flow reserve (PB-CFR) has been introduced. However, using pressure-only data, a substantial proportion of patients could not be classified into high or low PB-CFR and remained as indeterminate PB-CFR. The current study evaluated the prognostic implication of thermodilution-based CFR (thermo-CFR) in patients with indeterminate PB-CFR. METHODS: Among 199 patients (211 lesions) with indeterminate PB-CFR, 170 patients (179 lesions) with deferral of revascularization were analyzed for the current study...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29656784/combined-contribution-of-reduced-functional-mobility-muscle-weakness-and-low-serum-albumin-in-prediction-of-all-cause-mortality-in-hemodialysis-patients-a-retrospective-cohort-study
#12
Takahiro Shimoda, Ryota Matsuzawa, Kei Yoneki, Manae Harada, Takaaki Watanabe, Atsushi Yoshida, Yasuo Takeuchi, Atsuhiko Matsunaga
OBJECTIVES: The combined effects of reduced functional mobility, muscle weakness, and low serum albumin on mortality in hemodialysis patients have not been clarified. Here, we examined the associations of reduced functional mobility, muscle weakness, and low serum albumin-both alone and in combination-with all-cause mortality in hemodialysis patients. METHODS: A total of 490 patients treated between July 2010 and October 2016 were enrolled retrospectively in this study...
April 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29655951/acef-score-adapted-to-st-elevation-myocardial-infarction-patients-the-acef-stemi-score
#13
Martin Reindl, Sebastian Johannes Reinstadler, Christina Tiller, Markus Kofler, Markus Theurl, Nora Klier, Katherina Fleischmann, Agnes Mayr, Benjamin Henninger, Gert Klug, Bernhard Metzler
BACKGROUND: The age, creatinine and ejection fraction (ACEF) score has originally been developed for risk stratification of patients undergoing elective cardiac surgery. In patients with stable coronary artery disease treated by percutaneous coronary intervention (PCI), the prognostic accuracy of ACEF could be further improved by modifying the original scoring system (called "modified ACEF" or "ACEF-MDRD"). We aimed to specifically adapt the ACEF score for risk assessment of ST-elevation myocardial infarction (STEMI) patients...
April 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29650121/prediction-of-abnormal-myocardial-relaxation-from-signal-processed-surface-ecg
#14
Partho P Sengupta, Hemant Kulkarni, Jagat Narula
BACKGROUND: Myocardial relaxation is impaired in almost all cases with left ventricular diastolic dysfunction (LVDD) and is a strong predictor of cardiovascular and all-cause mortality. OBJECTIVES: This study investigated the feasibility of signal-processed surface electrocardiography (spECG) as a diagnostic tool for predicting the presence of abnormal cardiac muscle relaxation. METHODS: A total of 188 outpatients referred for coronary computed tomography (CT) angiography underwent an echocardiogram for assessment of LVDD...
April 17, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29644515/predictive-ability-of-perioperative-atrial-fibrillation-risk-indices-in-cardiac-surgery-patients-a-retrospective-cohort-study
#15
Nathan H Waldron, Mary Cooter, Jonathan P Piccini, Kevin J Anstrom, Rebecca Y Klinger, Miklos D Kertai, Mihai V Podgoreanu, Mark Stafford-Smith, Mark F Newman, Joseph P Mathew
PURPOSE: The Multicenter Study of Perioperative Ischemia (McSPI) AFRisk index predicts postoperative atrial fibrillation (POAF) after cardiac surgery, but requires pre-, intra-, and postoperative data. Other more abbreviated risk indices exist, but there is no consensus on which risk index is optimal. We compared the discriminatory capacity of the McSPI AFRisk index with three indices containing only preoperative data (the CHA2 DS2 Vasc score, POAF score, and Kolek clinical risk prediction model), hypothesizing that the McSPI AFRisk index would have superior predictive capacity...
April 11, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29622424/two-dimensional-global-longitudinal-strain-is-superior-to-left-ventricular-ejection-fraction-in-prediction-of-outcome-in-patients-with-left-sided-infective-endocarditis
#16
Trine Kiilerich Lauridsen, Christina Alhede, Anna Lisa Crowley, Joseph Kisslo, Lars L Sørensen, Thomas Fritz Hansen, Niels Risum, Carsten Toftager Larsen, Christian Hassager, Peter Søgaard, Anders Dahl, Niels Eske Bruun
BACKGROUND: Impaired cardiac function is the main predictor of poor outcome in infective endocarditis (IE). Global longitudinal strain (GLS) derived from two-dimensional strain echocardiography has proven superior in prediction of long-term outcome as compared to left ventricular ejection fraction (LVEF) in valvular disease and heart failure in general. Whether measurements of cardiac deformation can predict survival in patients with IE has not previously been investigated. METHODS: The study included consecutive patients with Duke definite IE who underwent transthoracic and transesophageal echocardiography within 7 days...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29604170/developing-and-validating-a-new-precise-risk-prediction-model-for-new-onset-hypertension-the-jichi-genki-hypertension-prediction-model-jg-model
#17
Hiroshi Kanegae, Takamitsu Oikawa, Kenji Suzuki, Yukie Okawara, Kazuomi Kario
No integrated risk assessment tools that include lifestyle factors and uric acid have been developed. In accordance with the Industrial Safety and Health Law in Japan, a follow-up examination of 63 495 normotensive individuals (mean age 42.8 years) who underwent a health checkup in 2010 was conducted every year for 5 years. The primary endpoint was new-onset hypertension (systolic blood pressure [SBP]/diastolic blood pressure [DBP] ≥ 140/90 mm Hg and/or the initiation of antihypertensive medications with self-reported hypertension)...
March 31, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29594025/active-surveillance-a-review-of-risk-based-dynamic-monitoring
#18
REVIEW
Daan Nieboer, Anirudh Tomer, Dimitris Rizopoulos, Monique J Roobol, Ewout W Steyerberg
Active surveillance (AS) is an important treatment modality aiming to reduce the overtreatment of patients with prostate cancer (PCa) who have a low risk of disease reclassification. After enrolling in AS patients are actively monitored using different diagnostic tests (e.g., prostate specific-antigen, digital rectal exams (DREs), medical imaging, and prostate biopsies). Biopsy is the most burdensome test. We aimed to review schedules for monitoring men on AS. We compare fixed versus risk based dynamic monitoring, where biopsies are scheduled during follow-up based on dynamic risk predictions...
February 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29594024/can-active-surveillance-really-reduce-the-harms-of-overdiagnosing-prostate-cancer-a-reflection-of-real-life-clinical-practice-in-the-prias-study
#19
Frank-Jan H Drost, Antti Rannikko, Riccardo Valdagni, Tom Pickles, Yoshiyuki Kakehi, Sebastiaan Remmers, Henk G van der Poel, Chris H Bangma, Monique J Roobol
Background: Active surveillance (AS) for low-risk prostate cancer (PCa) appears to provide excellent long-term PCa-specific and overall survival. The choice for AS as initial treatment is mainly based on avoiding side effects from invasive treatment; but AS entails regular check-ups and the possibility of still having to switch or deciding to switch to invasive treatment. Here, we assessed the long-term follow-up data from AS in real life clinical practices. Methods: Data from the first 500 men, enrolled in PRIAS before July 2008 by 30 centers across 8 countries, were analyzed to provide long-term follow-up results...
February 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29590199/the-urine-albumin-creatinine-ratio-is-a-predictor-for-incident-long-term-care-in-a-general-population
#20
Shuko Takahashi, Fumitaka Tanaka, Yuki Yonekura, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Akira Okayama, Motoyuki Nakamura
BACKGROUND: Several types of cardiovascular diseases (CVDs) impair the physical and mental status. The purpose of this study was to assess the predictive ability of several cardiovascular biomarkers for identifying the incidence of disability as future recipients of public long-term care (LTC) service. METHODS: The subjects of this study were community-dwelling elderly individuals ≥ 65 years of age without a history of CVD (n = 5,755; mean age, 71 years). The endpoint of this study was official certification as a recipient of LTC...
2018: PloS One
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