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https://www.readbyqxmd.com/read/28809988/methods-for-imputing-missing-efficacy-data-in-clinical-trials-of-biologic-psoriasis-therapies-implications-for-interpretations-of-trial-results
#1
Richard G B Langley, Kristian Reich, Charis Papavassilis, Todd Fox, Yankun Gong, Achim Gu Ttner
<p>BACKGROUND: An issue in long-term clinical trials of biologics in psoriasis is how to handle missing efficacy data. This methodological challenge may not be understood by clinicians, yet can have a significant effect on the interpretation of clinical trials.</p> <p>OBJECTIVE Evaluate the effects of different data imputation methods on apparent secukinumab response rates.</p> <p>METHODS: Post hoc analyses were conducted on efficacy data from 2 phase III, multicenter, randomized, double-blind trials (FIXTURE and ERASURE) of secukinumab in moderate to severe plaque psoriasis...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28808554/arthropod-communities-on-hybrid-and-parental-cottonwoods-are-phylogenetically-structured-by-tree-type-implications-for-conservation-of-biodiversity-in-plant-hybrid-zones
#2
Karl J Jarvis, Gerard J Allan, Ashley J Craig, Rebecca K Beresic-Perrins, Gina Wimp, Catherine A Gehring, Thomas G Whitham
Although hybridization in plants has been recognized as an important pathway in plant speciation, it may also affect the ecology and evolution of associated communities. Cottonwood species (Populus angustifolia and P. fremontii) and their naturally occurring hybrids are known to support different plant, animal, and microbial communities, but no studies have examined community structure within the context of phylogenetic history. Using a community composed of 199 arthropod species, we tested for differences in arthropod phylogenetic patterns within and among hybrid and parental tree types in a common garden...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28808041/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#3
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loïc Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazards model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28799620/long-term-bleeding-risk-prediction-in-real-world-patients-with-atrial-fibrillation-comparison-of-the-has-bled-and-abc-bleeding-risk-scores-the-murcia-atrial-fibrillation-project
#4
María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan, Vicente Vicente, Mariano Valdés, Francisco Marín, Gregory Y H Lip
Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better than HAS-BLED score in a clinical trial cohort but has not been externally validated. It was the aim of this study to compare the predictive performance of the ABC-Bleeding score compared to HAS-BLED score in an independent "real-world" anticoagulated AF patients with long-term follow-up...
August 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28789846/additive-value-of-the-crusade-score-to-the-grace-score-for-mortality-risk-prediction-in-patients-with-acute-coronary-syndromes
#5
Alberto Cordero, Moisés Rodriguez-Manero, Jose M García-Acuña, Ramón López-Palop, Belen Cid, Pilar Carrillo, Rosa Agra-Bermejo, Violeta González-Salvado, Diego Iglesias-Alvarez, Vicente Bertomeu-Martínez, Jose R González-Juanatey
INTRODUCTION: Acute coronary syndrome (ACS) treatments increase bleeding complications that also impair prognosis. Bleeding risk scores reclassification of actual mortality risk estimated by the GRACE score might improve overall estimation. METHODS: Observational and prospective study of all ACS patients admitted in two hospitals. Mortality risk was assessed by the GRACE score and bleeding risk by the CRUSADE score. We analyzed the net reclassification improvement (NRI) of adding the CRUSADE score to the GRACE score...
August 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28782750/homocysteine-enhances-the-predictive-value-of-the-grace-risk-score-in-patients-with-st-elevation-myocardial-infarction
#6
Yan Fan, Jianjun Wang, Sumei Zhang, Zhaofei Wan, Dong Zhou, Yanhong Ding, Qinli He, Ping Xie
OBJECTIVE: The present study aims to investigate whether the addition of homocysteine level to the Global Registry of Acute Coronary Events (GRACE) risk score enhances its predictive value for clinical outcomes in ST-elevation myocardial infarction (STEMI). METHODS: A total of 1143 consecutive patients with STEMI were included in this prospective cohort study. Homocysteine was detected, and the GRACE score was calculated. The predictive power of the GRACE score alone or combined with homocysteine was assessed by the receiver operating characteristic (ROC) analysis, methods of net reclassification improvement (NRI) and integrated discrimination improvement (IDI)...
August 4, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28774268/prognostic-value-of-short-term-follow-up-bnp-in-hospitalized-patients-with-heart-failure
#7
Sayma Sabrina Khanam, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Junghan Yoon, Seung-Hwan Lee, Jang-Young Kim, Sung Gyun Ahn, Min-Soo Ahn, Byung-Su Yoo
BACKGROUND: B-type natriuretic peptide (BNP) has prognostic significance in heart failure (HF), and reductions in BNP may predict clinical improvement. However, there are limited data regarding the prognostic value of BNP during short-term follow-up. The aim of this study was to evaluate the relationship between short-term follow-up BNP and mortality after discharge in patients with HF. METHODS: We analyzed 427 patients hospitalized with HF from the Wonju Severance Christian Hospital Heart Failure Registry from April 2011 to December 2013, with a planned follow-up period through February 2016...
August 3, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28773951/a-new-compact-double-negative-miniaturized-metamaterial-for-wideband-operation
#8
Md Mehedi Hasan, Mohammad Rashed Iqbal Faruque, Sikder Sunbeam Islam, Mohammad Tariqul Islam
The aim of this paper is to introduce a compact double-negative (DNG) metamaterial that exhibits a negative refractive index (NRI) bandwidth of more than 3.6 GHz considering the frequency from 2 to 14 GHz. In this framework, two arms of the designed unit cell are split in a way that forms a Modified-Z-shape structure of the FR-4 substrate material. The finite integration technique (FIT)-based Computer Simulation Technology (CST) Microwave Studio is applied for computation, and the experimental setup for measuring the performance is performed inside two waveguide ports...
October 13, 2016: Materials
https://www.readbyqxmd.com/read/28771550/gdf-15-predicts-cardiovascular-events-in-acute-chest-pain-patients
#9
Stergios Tzikas, Lars Palapies, Constantinos Bakogiannis, Tanja Zeller, Christoph Sinning, Stephan Baldus, Christoph Bickel, Vassilios Vassilikos, Karl J Lackner, Andreas Zeiher, Thomas Münzel, Stefan Blankenberg, Till Keller
BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI. METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI...
2017: PloS One
https://www.readbyqxmd.com/read/28761677/comparison-of-the-chronic-kidney-disease-epidemiology-collaboration-the-modification-of-diet-in-renal-disease-study-and-the-cockcroft-gault-equation-in-patients-with-heart-failure
#10
Karolina Szummer, Marie Evans, Juan Jesus Carrero, Urban Alehagen, Ulf Dahlström, Lina Benson, Lars H Lund
BACKGROUND: It is unknown how the creatinine-based renal function estimations differ for dose adjustment cut-offs and risk prediction in patients with heart failure. METHOD AND RESULTS: The renal function was similar with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (median 59 mL/min/1.73 m(2), IQR 42 to 77) and Modification of Diet in Renal Disease Study (MDRD) (59 mL/min/1.73 m(2), IQR 43 to 75) and slightly lower with the Cockcroft-Gault (CG) equation (57 mL/min, IQR 39 to 82)...
2017: Open Heart
https://www.readbyqxmd.com/read/28754641/improving-the-prognostic-value-of-disease-specific-graded-prognostic-assessment-ds-gpa-model-for-renal-cell-carcinoma-by-incorporation-of-cumulative-intracranial-tumor-volume-citv
#11
Mir Amaan Ali, Brian R Hirshman, Bayard Wilson, Alexander J Schupper, Rushikesh Joshi, James A Proudfoot, Steven J Goetsch, John F Alksne, Kenneth Ott, Hitoshi Aiyama, Osamu Nagano, Bob S Carter, Veronica Chiang, Toru Serizawa, Masaaki Yamamoto, Clark C Chen
BACKGROUND: We tested the prognostic value of cumulative intracranial tumor volume (CITV) in the context of ds-GPA model for renal cell carcinoma (RCC) patients with brain metastasis (BM) treated with stereotactic radiosurgery (SRS). METHODS: Patient and tumor characteristics were collected from RCC cohorts with newly BM who underwent SRS. Univariable and multivariable logistic regression model was used to test the prognostic value of CITV, Karnofsky Performance Score (KPS), and the number of BM...
July 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28750645/comparative-effects-of-microvascular-and-macrovascular-disease-on-the-risk-of-major-outcomes-in-patients-with-type-2-diabetes
#12
Kamel Mohammedi, Mark Woodward, Michel Marre, Stephen Colagiuri, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers
BACKGROUND: Microvascular disease is associated with a high risk of macrovascular events in patients with type 2 diabetes, but the impact of macrovascular disease on the risk of microvascular events remains unknown. We sought to evaluate the respective effects of prior microvascular and macrovascular disease on the risk of major outcomes, including microvascular events, in these patients. METHODS: Participants in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) trial (n = 11,140) and the ADVANCE-ON post-trial study (n = 8494) were categorized into 4 groups at baseline: dual absence of microvascular or macrovascular disease (n = 6789), presence of microvascular disease alone (n = 761), macrovascular disease alone (n = 3196), and both (n = 394)...
July 27, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28738057/the-fatty-liver-index-as-a-predictor-of-incident-chronic-kidney-disease-in-a-10-year-prospective-cohort-study
#13
Ji Hye Huh, Jang Young Kim, Eunhee Choi, Jae Seok Kim, Yoosoo Chang, Ki-Chul Sung
BACKGROUND: Although non-alcoholic fatty liver disease (NAFLD) is considered to be associated with chronic kidney disease (CKD), long-term follow up data is lacking. We investigated whether NAFLD, as determined by the fatty liver index (FLI), could predict incident CKD in 10-year prospective cohort study. We also assessed the clinical utility of FLI to predict the development of CKD. METHODS: 6,238 adults aged 40 to 69 years without baseline CKD from the Ansan-Ansung cohort were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28729865/a-novel-and-validated-protocol-for-performing-mic-tests-to-determine-the-susceptibility-of-piscirickettsia-salmonis-isolates-to-florfenicol-and-oxytetracycline
#14
Sergio Contreras-Lynch, Peter Smith, Paola Olmos, María E Loy, William Finnegan, Claudio D Miranda
This paper presents a validated protocol, using a novel, specifically formulated medium, to perform broth microdilution antimicrobial susceptibility assays of the salmonid bacterial pathogen Piscirickettsia salmonis. The minimum inhibitory concentrations (MIC) for florfenicol and oxytetracycline against 58 P. salmonis isolates recovered from various outbreaks occurred in Chilean salmonid farms were determined using this protocol. Normalized resistance interpretation (NRI) analysis was applied to these data to calculate appropriate protocol-specific epidemiological cut-off values...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28729251/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#15
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loic Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazard model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28719899/the-relationship-between-mmp-2-1306c-t-and-mmp-9-1562c-t-polymorphisms-and-the-risk-and-prognosis-of-t-cell-acute-lymphoblastic-leukemia-in-a-chinese-population-a-case-control-study
#16
Cong-Meng Lin, Yan-Ling Zeng, Min Xiao, Xu-Qiao Mei, Lv-Ying Shen, Meng-Xian Guo, Zhe-Yao Lin, Qi-Fa Liu, Tin Yang
BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease and is often accompanied by a variety of genetic abnormalities. Hence, our study aims to investigate the relationship between MMP-2 -1306C>T and MMP-9 -1562C>T polymorphisms and the risk and prognosis of T-ALL. METHODS: From April 2009 to February 2011, a total of 376 T-ALL patients were chosen as the case group. Meanwhile, 352 healthy people who passed routine health examinations were selected as the control group...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28688158/determination-of-hepatocellular-carcinoma-grade-by-needle-biopsy-is-unreliable-for-liver-transplant-candidate-selection
#17
Colin M Court, Michael P Harlander-Locke, Daniela Markovic, Samuel W French, Bita V Naini, David S Lu, Steven S Raman, Fady M Kaldas, Ali Zarrinpar, Douglas G Farmer, Richard S Finn, Saeed Sadeghi, James S Tomlinson, Ronald W Busuttil, Vatche G Agopian
OBJECTIVE: To evaluate the utility of preoperative needle biopsy (PNB) grading of hepatocellular carcinoma (HCC) as a biomarker for liver transplant (LT) candidate selection. BACKGROUND: Given the prognostic significance of HCC tumor grade, PNB grading has been proposed as a biomarker for LT candidate selection. METHODS: Clinicopathologic characteristics of HCC LT recipients (1989-2014) with a PNB were analyzed, and concordance of PNB grade to explant grade and vascular invasion was assessed to determine whether incorporation of PNB grade to accepted transplant criteria improved candidate selection...
July 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28686352/the-ratio-of-visceral-to-subcutaneous-fat-area-predicts-cardiovascular-events-in-patients-with-type-2-diabetes
#18
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes. MATERIALS AND METHODS: 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% female) were enrolled. VFA (cm(2) ) and SFA (cm(2) ) were assessed by dual bioelectrical impedance analyzer (BIA). The patients were divided into four groups according to the quartiles of V/S ratio...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28684396/cardiac-stress-and-inflammatory-markers-as-predictors-of-heart-failure-in-patients-with-type-2-diabetes-the-advance-trial
#19
Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers
OBJECTIVE: This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A nested case-cohort study was conducted in 3,098 participants with type 2 diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial...
July 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hgf-and-plgf-predict-mortality-in-a-general-population-a-prospective-cohort-study
#20
Kristiina Santalahti, Aki Havulinna, Mikael Maksimow, Tanja Zeller, Stefan Blankenberg, Aki Vehtari, Heikki Joensuu, Sirpa Jalkanen, Veikko Salomaa, Marko Salmi
BACKGROUND: Circulating levels of growth factors involved in leukocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N=8444, aged 25-74; 2002 Replication cohort, N=2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
July 6, 2017: Journal of Internal Medicine
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