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https://www.readbyqxmd.com/read/27933194/contribution-of-the-long-term-care-insurance-certificate-for-predicting-1-year-all-cause-readmission-compared-with-validated-risk-scores-in-elderly-patients-with-heart-failure
#1
Kayo Takahashi, Makoto Saito, Shinji Inaba, Toru Morofuji, Hiroe Aisu, Takumi Sumimoto, Akiyoshi Ogimoto, Shuntaro Ikeda, Jitsuo Higaki
OBJECTIVES: Readmission is a common and serious problem associated with heart failure (HF). Unfortunately, conventional risk models have limited predictive value for predicting readmission. The recipients of long-term care insurance (LTCI) are frail and have mental and physical impairments. We hypothesised that adjustment of the conventional risk score with an LTCI certificate enables a more accurate appreciation of readmission for HF. METHODS: We investigated 452 patients with HF who were followed up for 1 year to determine all-cause readmission...
2016: Open Heart
https://www.readbyqxmd.com/read/27933043/antimicrobial-susceptibility-of-flavobacterium-psychrophilum-from-chilean-salmon-farms-and-their-epidemiological-cut-off-values-using-agar-dilution-and-disk-diffusion-methods
#2
Claudio D Miranda, Peter Smith, Rodrigo Rojas, Sergio Contreras-Lynch, J M Alonso Vega
Flavobacterium psychrophilum is the most important bacterial pathogen for freshwater farmed salmonids in Chile. The aims of this study were to determine the susceptibility to antimicrobials used in fish farming of Chilean isolates and to calculate their epidemiological cut-off (COWT) values. A number of 125 Chilean isolates of F. psychrophilum were isolated from reared salmonids presenting clinical symptoms indicative of flavobacteriosis and their identities were confirmed by 16S rRNA polymerase chain reaction...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27932413/biomarkers-and-coronary-lesions-predict-outcomes-after-revascularization-in-non-st-elevation-acute-coronary-syndrome
#3
Daniel Lindholm, Stefan K James, Maria Bertilsson, Richard C Becker, Christopher P Cannon, Evangelos Giannitsis, Robert A Harrington, Anders Himmelmann, Frederic Kontny, Agneta Siegbahn, Philippe Gabriel Steg, Robert F Storey, Matthijs A Velders, W Douglas Weaver, Lars Wallentin
BACKGROUND: Risk stratification in non-ST-elevation acute coronary syndrome (NSTE-ACS) is currently mainly based on clinical characteristics. With routine invasive management, angiography findings and biomarkers are available and may improve prognostication. We aimed to assess if adding biomarkers [high-sensitivity cardiac troponin T (cTnT-hs), N-terminal probrain-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15)] and extent of coronary artery disease (CAD) might improve prognostication in revascularized patients with NSTE-ACS...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27927714/contemporary-assessment-of-left-ventricular-diastolic-function-in-older-adults-the-atherosclerosis-risk-in-communities-study
#4
Amil M Shah, Brian Claggett, Dalane Kitzman, Tor Biering-Sørensen, Jan S Jensen, Susan Cheng, Kunihiro Matsushita, Suma H Konety, Aaron R Folsom, Thomas H Mosley, Jacqueline Wright, Gerardo Heiss, Scott D Solomon
BACKGROUND: -While age-associated changes in LV diastolic function are well-recognized, limited data exist characterizing measures of diastolic function in older adults, including both reference ranges reflecting the older adult population and prognostically relevant values for incident HF, as well as their associations with circulating biomarkers of heart failure (HF) risk. METHODS: -Among 5,801 elderly participants in the Atherosclerosis Risk in Communities (ARIC) study (age range 67-90, mean age 76 ± 5, 42% male, 21% black), we determined the continuous association of diastolic measures (TDI e', E/e', and left atrial size) with concomitant NT-proBNP and subsequent HF hospitalization or death...
December 7, 2016: Circulation
https://www.readbyqxmd.com/read/27925214/acute-and-chronic-effects-of-noradrenergic-enhancement-on-transcranial-direct-current-stimulation-induced-neuroplasticity-in-humans
#5
Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo, Michael A Nitsche
KEY POINTS: Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases...
November 7, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27899297/validation-of-the-afp-model-as-a-predictor-of-hcc-recurrence-in-patients-with-viral-hepatitis-related-cirrhosis-who-had-received-a-liver-transplant-for-hcc
#6
Andrea Notarpaolo, Richard Layèse, Paolo Magistri, Maria Gambato, Michele Colledan, Giulia Magini, Lucia Miglioresi, Alessandro Vitale, Giovanni Vennarecci, Cecilia D Ambrosio, Patrizia Burra, Fabrizio Di Benedetto, Stefano Fagiuoli, Marco Colasanti, Giuseppe Maria Ettorre, Arnoldo Andreoli, Umberto Cillo, Alexis Laurent, Sandrine Katsahian, Etienne Audureau, Françoise Roudot-Thoraval, Christophe Duvoux
BACKGROUND AND AIMS: The AFP model was shown superior to Milan criteria for prediction of HCC recurrence after liver transplantation in a French population. Our aim was to test the AFP model in a non French, post-hepatitic cirrhosis-based population of HCC candidates. METHODS: 574 patients transplanted for HCC in 4 Italian centres were studied. AFP score was assessed at last evaluation before LT. Probabilities of recurrence and survival were estimated by the log rank test or competing risk analysis and compared according to the AFP model...
November 26, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27893697/morbidity-and-mortality-predictivity-of-nutritional-assessment-tools-in-the-postoperative-care-unit
#7
Şule Özbilgin, Volkan Hanc, Dilek Ömür, Mücahit Özbilgin, Mine Tosun, Serhan Yurtlu, Semih Küçükgüçlü, Atalay Arkan
The aim was to evaluate the nutritional situation of patients admitted to the Postoperative Acute Care Unit using classic methods of objective anthropometry, systemic evaluation methods, and Nutrition Risk in Critically Ill (NUTRIC) score, and to compare them as a predictor of morbidity and mortality.At admission to the postoperative care unit, patients undergoing various surgeries were assessed for the following items: Subjective Global Assessment (SGA), Nutritional Risk Index (NRI), Nutritional Risk Screening (NRS)-2002, Mini Nutritional Assessment (MNA), Charlson comorbidity index (CCI), and NUTRIC score, anthropometric measurements, serum total protein, serum albumin, and lymphocyte count...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27892887/cardiorespiratory-fitness-and-nonfatalcardiovascular-events-a-population-based-follow-up-study
#8
Hassan Khan, Nabil Jaffar, Rainer Rauramaa, Sudhir Kurl, Kai Savonen, Jari A Laukkanen
BACKGROUND: To examine the prognostic value of cardiorespiratory fitness (CRF) with risk of first major nonfatal myocardial infarction (MI), stroke, and heart failure (HF) events. METHODS: Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed at baseline in a prospective cohort of 2,089 men aged 42 to 61years. RESULTS: During a mean (SD) follow-up of 19.1(8.4) years, 522 nonfatal acute MI events, 198 acute all-cause nonfatal stroke events, and 221 nonfatal HF events were recorded...
November 2, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27867511/is-tapentadol-different-from-classical-opioids-a-review-of-the-evidence
#9
Richard M Langford, Roger Knaggs, Paul Farquhar-Smith, Anthony H Dickenson
Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradrenaline re-uptake inhibition. From these, one may predict that tapentadol would be applicable across a broad spectrum of pain from nociceptive to neuropathic. The evidence in animal models suggests that norepinephrine re-uptake inhibition (NRI) is a key mechanism and may even predominate over opioid actions in chronic (and especially neuropathic) pain states, reinforcing that tapentadol is different to classical opioids and may, therefore, be an a priori choice for the treatment of neuropathic and mixed pain...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27863481/association-of-nutritional-status-related-indices-and-chemotherapy-induced-adverse-events-in-gastric-cancer-patients
#10
Seung Hee Seo, Sung-Eun Kim, Yoon-Koo Kang, Baek-Yeol Ryoo, Min-Hee Ryu, Jae Ho Jeong, Shin Sook Kang, Mihi Yang, Jung Eun Lee, Mi-Kyung Sung
BACKGROUND: Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemotherapy. METHODS: Medical records of 234 gastrectomized patients under adjuvant tegafur/gimeracil/oteracil chemotherapy with extended lymph node dissection were analyzed...
November 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27859688/normalized-resistance-interpretation-the-nri-method-review-of-nri-disc-test-applications-and-guide-to-calculations
#11
REVIEW
Göran Kronvall, Peter Smith
The normalized resistance interpretation (NRI) method was developed in response to a call for a method to calibrate disc diffusion test results making inter-laboratory comparisons possible. The main use of NRI so far has been in individual laboratories, in medical and veterinary medicine and in the field of marine microbiology. The applications of NRI for disc diffusion tests are reviewed and, in addition, a detailed description of the calculation procedure is presented. NRI provides a fully objective method for ECOFF calculations of disc diffusion antimicrobial susceptibility test results...
December 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27855108/diagnostic-rules-and-algorithms-for-the-diagnosis-of-non-acute-heart-failure-in-patients-80%C3%A2-years-of-age-and-older-a-diagnostic-accuracy-and-validation-study
#12
Miek Smeets, Jan Degryse, Stefan Janssens, Catharina Matheï, Pierre Wallemacq, Jean-Louis Vanoverschelde, Bert Aertgeerts, Bert Vaes
OBJECTIVES: Different diagnostic algorithms for non-acute heart failure (HF) exist. Our aim was to compare the ability of these algorithms to identify HF in symptomatic patients aged 80 years and older and identify those patients at highest risk for mortality. DESIGN: Diagnostic accuracy and validation study. SETTING: General practice, Belgium. PARTICIPANTS: 365 patients with HF symptoms aged 80 years and older (BELFRAIL cohort)...
October 6, 2016: BMJ Open
https://www.readbyqxmd.com/read/27851788/dietary-information-improves-model-performance-and-predictive-ability-of-a-noninvasive-type-2-diabetes-risk-model
#13
Tianshu Han, Shuang Tian, Li Wang, Xi Liang, Hongli Cui, Shanshan Du, Guanqiong Na, Lixin Na, Changhao Sun
There is no diabetes risk model that includes dietary predictors in Asia. We sought to develop a diet-containing noninvasive diabetes risk model in Northern China and to evaluate whether dietary predictors can improve model performance and predictive ability. Cross-sectional data for 9,734 adults aged 20-74 years old were used as the derivation data, and results obtained for a cohort of 4,515 adults with 4.2 years of follow-up were used as the validation data. We used a logistic regression model to develop a diet-containing noninvasive risk model...
2016: PloS One
https://www.readbyqxmd.com/read/27844133/gait-speed-and-one-leg-standing-time-each-add-to-the-predictive-ability-of-frax
#14
H Lundin, M Sääf, L-E Strender, S Nyren, S-E Johansson, H Salminen
: Gait speed or one-leg standing time (OLST) as additional predictors in FRAX. Population 351 elderly women followed 10 years. Both could improve predictions. The area under curve (AUC) for FRAX is 0.59, OLST is 0.69 and gait speed is 0.71. The net reclassification index (NRI) for classification to highest risk quartile or lowest three quartiles was 0.24 for gait speed and non-significant for OLST. INTRODUCTION: The risk of falls and bone strength are two main determinants of hip fracture risk...
November 14, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27832125/cluster-individuals-based-on-phenotype-and-determine-the-risk-for-atrial-fibrillation-in-the-prevend-and-framingham-heart-study-populations
#15
Michiel Rienstra, Bastiaan Geelhoed, Xiaoyan Yin, Joylene E Siland, Rob A Vermond, Bart A Mulder, Pim Van Der Harst, Hans L Hillege, Emelia J Benjamin, Isabelle C Van Gelder
BACKGROUND: Risk prediction of atrial fibrillation (AF) is of importance to improve the early diagnosis and treatment of AF. Latent class analysis takes into account the possible existence of classes of individuals each with shared risk factors, and maybe a better method of incorporating the phenotypic heterogeneity underlying AF. METHODS AND FINDINGS: Two prospective community-based cohort studies from Netherlands and United States were used. Prevention of Renal and Vascular End-stage Disease (PREVEND) study, started in 1997, and the Framingham Heart Study (FHS) Offspring cohort started in 1971, both with 10-years follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27815493/net-reclassification-index-nri-and-integrated-discrimination-index-idi-are-not-appropriate-for-testing-whether-a-biomarker-improves-predictive-performance
#16
Peter M Burch, Warren E Glaab, Daniel J Holder, Jonathan A Phillips, John-Michael Sauer, Elizabeth G Walker
One of the goals of the Critical Path Institute's Predictive Safety Testing Consortium (PSTC) is to promote best practices for evaluating novel markers of drug induced injury. This includes the use of sound statistical methods. For rat studies, these practices have centered around comparing the area under the receiver-operator characteristic (ROC) curve for each novel injury biomarker to those for the standard markers. In addition, the PSTC has previously used the net reclassification index (NRI) and integrated discrimination index (IDI) to assess the increased certainty provided by each novel injury biomarker when added to the information already provided by the standard markers...
November 4, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27812517/a-study-on-the-dietary-intake-and-the-nutritional-status-among-the-pancreatic-cancer-surgical-patients
#17
Jimin Kang, Joon Seong Park, Dong Sup Yoon, Woo Jeong Kim, Hae-Yun Chung, Song Mi Lee, Namsoo Chang
The adequate dietary intake is important to maintain the nutritional status of the patients after pancreatic cancer surgery. This prospective study was designed to investigate the dietary intake and the nutritional status of the patients who had pancreatic cancer surgery. Thirty-one patients (15 men, 16 women) were enrolled and measured body weight, body mass index (BMI), nutritional risk index (NRI), and Malnutrition Universal Screening Tool (MUST). Actual oral intake with nutritional impact symptoms recorded on the clinical research foam at every meal and medical information were collected from electronic medical charts...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27809713/improved-predictive-value-of-grace-risk-score-combined-with-platelet-reactivity-for-1-year-cardiovascular-risk-in-patients-with-acute-coronary-syndrome-who-underwent-coronary-stent-implantation
#18
Shan Li, Hongbin Liu, Jianfeng Liu, Haijun Wang
Both high platelet reactivity (HPR) and Global Registry of Acute Coronary Events (GRACE) risk score have moderate predictive value for major adverse cardiovascular disease (CVD) events in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI), whereas the prognostic significance of GRACE risk score combined with platelet function testing remains unclear. A total of 596 patients with non-ST elevation ACS who underwent PCI were enrolled. The P2Y12 reaction unit (PRU) value was measured by VerifyNow P2Y12 assay and GRACE score was calculated by GRACE risk 2...
November 2016: Platelets
https://www.readbyqxmd.com/read/27802302/a-predictive-model-for-assessing-surgery-related-acute-kidney-injury-risk-in-hypertensive-patients-a-retrospective-cohort-study
#19
Xing Liu, Yongkai Ye, Qi Mi, Wei Huang, Ting He, Pin Huang, Nana Xu, Qiaoyu Wu, Anli Wang, Ying Li, Hong Yuan
BACKGROUND: Acute kidney injury (AKI) is a serious post-surgery complication; however, few preoperative risk models for AKI have been developed for hypertensive patients undergoing general surgery. Thus, in this study involving a large Chinese cohort, we developed and validated a risk model for surgery-related AKI using preoperative risk factors. METHODS AND FINDINGS: This retrospective cohort study included 24,451 hypertensive patients aged ≥18 years who underwent general surgery between 2007 and 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27792652/incremental-value-of-speckle-tracking-echocardiography-to-predict-cardiac-resynchronization-therapy-crt-responders
#20
Yoshihiro Seo, Tomoko Ishizu, Tomoko Machino-Ohtsuka, Masayoshi Yamamoto, Takeshi Machino, Kenji Kuroki, Hiro Yamasaki, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma
BACKGROUND: Speckle tracking echocardiography (STE) is reported as a useful method to predict cardiac resynchronization therapy (CRT) responders. This study aimed to identify the incremental value of a STE parameter to predict CRT responders. METHODS AND RESULTS: We enrolled 171 patients from the Speckle Tracking imaging for the Assessment of cardiac Resynchronization Therapy (START) study. CRT responders were defined as patients with ≥15% reduction of left ventricular (LV) end-systolic volume at 6 months post-CRT...
October 19, 2016: Journal of the American Heart Association
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