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https://www.readbyqxmd.com/read/28432897/hba1c-variability-in-type-2-diabetes-is-associated-with-the-occurrence-of-new-onset-albuminuria-within-three-years
#1
Sreemanee Raaj Dorajoo, Joceline Shi Ling Ng, Jessica Hui Fen Goh, Su Chi Lim, Chun Wei Yap, Alexandre Chan, Joyce Yu Chia Lee
AIMS: To evaluate the association between HbA1c coefficient of variation (HbA1c-CV) and 3-year new-onset albuminuria risk. METHODS: A retrospective cohort study involving 716 normoalbuminuric type 2 diabetes patients was conducted between 2010 and 2014. HbA1c-CV was used to categorize patients into low, moderate or high variability groups. Multivariate logistic models were constructed and validated. Integrated discrimination (IDI) and net reclassification (NRI) improvement indices were used to quantify the added predictive value of HbA1c-CV...
February 14, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28430976/acute-and-chronic-noradrenergic-effects-on-cortical-excitability-in-healthy-humans
#2
Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo, Michael A Nitsche
Background: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation (TMS) studies suggested that acute application of selective noradrenaline reuptake inhibitors (NRI) enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged NRI treatment, which might go along with different physiological effects...
April 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28422306/development-of-a-novel-frailty-index-to-predict-mortality-in-patients-with-end-stage-liver-disease
#3
Jennifer C Lai, Kenneth E Covinsky, Jennifer L Dodge, W John Boscardin, Dorry L Segev, John P Roberts, Sandy Feng
BACKGROUND: Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the MELDNa score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in cirrhotics. METHODS: Consecutive outpatients listed for LT at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting due to sickness)...
April 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28410581/statistical-evaluation-of-adding-multiple-risk-factors-improves-framingham-stroke-risk-score
#4
Xiao-Hua Zhou, Xiaonan Wang, Ashlee Duncan, Guizhou Hu, Jiayin Zheng
BACKGROUND: Framingham Stroke Risk Score (FSRS) is the most well-regarded risk appraisal tools for evaluating an individual's absolute risk on stroke onset. However, several widely accepted risk factors for stroke were not included in the original Framingham model. This study proposed a new model which combines an existing risk models with new risk factors using synthesis analysis, and applied it to the longitudinal Atherosclerosis Risk in Communities (ARIC) data set. METHODS: Risk factors in original prediction models and new risk factors in proposed model had been discussed...
April 14, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28379333/comparison-of-coronary-artery-calcification-carotid-intima-media-thickness-and-ankle-brachial-index-for-predicting-10-year-incident-cardiovascular-events-in-the-general-population
#5
Marie Henrike Geisel, Marcus Bauer, Frauke Hennig, Barbara Hoffmann, Nils Lehmann, Stefan Möhlenkamp, Knut Kröger, Kaffer Kara, Tobias Müller, Susanne Moebus, Raimund Erbel, André Scherag, Karl-Heinz Jöckel, Amir A Mahabadi
Aims: To compare the predictive value of coronary artery calcification (CAC), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) in a primary prevention cohort depending on risk factor profile to determine which of the three markers improves cardiovascular (CV) risk discrimination best in which risk group. Methods and results: We quantified CAC, CIMT, and ABI in 3108 subjects (mean age 59.2 ± 7.7, 47.1% male) without prevalent CV diseases from the population-based Heinz Nixdorf Recall study...
March 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28368516/validation-of-the-origin-cardiovascular-biomarker-panel-and-the-value-of-adding-troponin-i-in-dysglycemic-people
#6
Hertzel C Gerstein, Guillaume Paré, Matthew J McQueen, Shun Fu Lee, Sibylle Hess
Background: Analyses of stored blood from the ORIGIN trial (Outcomes Reduction with an Initial Glargine Intervention) identified biomarkers that supplemented clinical risk factors for cardiovascular (CV) events or death. Their performance in participants with diabetes in the Heart Outcomes Prevention Evaluation (HOPE) study, and the incremental value of adding high sensitivity troponin I (hsTnI) in the ORIGIN study was assessed. Methods: Levels of the 10 ORIGIN biomarkers for the composite cardiovascular outcome of myocardial infarction, stroke or CV death were measured in 350 HOPE study participants with diabetes and stored serum that included all 77 who experienced this outcome...
March 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28365268/diagnostic-performance-of-resting-and-hyperemic-invasive-physiological-indices-to-define-myocardial-ischemia-validation-with-13-n-ammonia-positron-emission-tomography
#7
Doyeon Hwang, Ki-Hyun Jeon, Joo Myung Lee, Jonghanne Park, Chee Hae Kim, Yaliang Tong, Jinlong Zhang, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Sang-Hoon Na, Gi Jeong Cheon, Christopher M Cook, Justin E Davies, Bon-Kwon Koo
OBJECTIVES: The authors sought to compare the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and resting distal coronary artery pressure/aortic pressure (Pd/Pa) using (13)N-ammonia positron emission tomography (PET). BACKGROUND: The diagnostic performance of invasive physiological indices was reported to be different according to the reference to define the presence of myocardial ischemia. METHODS: A total of 115 consecutive patients with left anterior descending artery stenosis who underwent both (13)N-ammonia PET and invasive physiological measurement were included...
March 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28363203/improved-5-year-prediction-of-all-cause-mortality-by-coronary-ct-angiography-applying-the-confirm-score
#8
Simon Deseive, Leslee J Shaw, James K Min, Stephan Achenbach, Daniele Andreini, Mouaz H Al-Mallah, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Filippo Cademartiri, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Allison M Dunning, Gudrun Feuchtner, Philipp A Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Hugo Marques, Erica Maffei, Gianluca Pontone, Gilbert Raff, Ronin Rubinshtein, Todd C Villines, Jörg Hausleiter, Martin Hadamitzky
Aims: To investigate the long-term performance of the CONFIRM score for prediction of all-cause mortality in a large patient cohort undergoing coronary computed tomography angiography (CCTA). Methods and results: Patients with a 5-year follow-up from the international multicentre CONFIRM registry were included. The primary endpoint was all-cause mortality. The predictive value of the CONFIRM score over clinical risk scores (Morise, Framingham, and NCEP ATP III score) was studied in the entire patient population as well as in subgroups...
March 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28361468/impact-of-participation-in-the-adalimumab-humira-patient-support-program-on-rheumatoid-arthritis-treatment-course-results-from-the-passion-study
#9
Filip Van den Bosch, Andrew J K Ostor, Siegfried Wassenberg, Naijun Chen, Chen Wang, Vishvas Garg, Jasmina Kalabic
INTRODUCTION: Patients with rheumatoid arthritis (RA) who are treated with adalimumab (ADA) are offered a proprietary patient support program (PSP, AbbVie Care(®)). The main objective of this study was to examine the effectiveness of ADA on RA treatment course over time in the context of PSP utilization. METHODS: PASSION was a 78-week post-marketing observational study of RA patients with an insufficient response to ≥1 DMARD newly initiating ADA in routine clinical care that was conducted in Europe, Israel, Mexico, Puerto Rico, and Australia...
March 30, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28327369/plasma-proanp1-98-levels-are-positively-associated-with-central-obesity-a-cross-sectional-study-in-a-general-population-of-china
#10
Zhengbao Zhu, Qiu Zhang, Hao Peng, Chongke Zhong, Yan Liu, Xinfeng Huangfu, Yunfan Tian, Xiangqin Chao, Aili Wang, Jianhua Jin, Yonghong Zhang
BACKGROUND: Atrial natriuretic peptide (ANP) and its prohormone activating enzyme are associated with central obesity, suggesting there may be a potential relationship between proANP1-98 and central obesity. However, the association is still lack of population-based evidence. We explored the association in a general population of China. METHODS: We measured plasma proANP1-98, waist circumference and other traditional biomarkers in 2203 participants aged≥30y. Multivariate logistic regression models were used to determine the association between plasma proANP1-98 and central obesity, and odds ratio (OR) and 95% confidence interval (CI) were calculated...
March 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28300429/leptin-predicts-short-term-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#11
Veli-Pekka Puurunen, Antti Kiviniemi, Samuli Lepojärvi, Olli-Pekka Piira, Pirjo Hedberg, Juhani Junttila, Olavi Ukkola, Heikki Huikuri
INTRODUCTION: Leptin is an adipose tissue-derived hormone associated with cardiovascular risk factors. We examined whether leptin predicts major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. METHODS: Fasting plasma leptin levels were measured in 1327 male and 619 female CAD patients. The patients were followed up for two years. The primary endpoint (MACE) was the composite of a hospitalisation for congestive heart failure (CHF) or a cardiac death...
March 16, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28276598/clinical-utility-of-using-lumbar-spine-trabecular-bone-score-to-adjust-fracture-probability-the-manitoba-bmd-cohort
#12
Patrick Martineau, William D Leslie, Helena Johansson, Anders Oden, Eugene V McCloskey, Didier Hans, John A Kanis
Decreased lumbar spine trabecular bone score (TBS), a dual-energy X-ray absorptiometry (DXA)-derived image texture measurement, is a risk factor for major osteoporotic fracture (MOF) and hip fracture (HF) independent of 10-year fracture probability estimated using FRAX. We determined how often applying the TBS adjustment to fracture probability altered treatment qualification. Using a population-based registry containing all clinical DXA results for Manitoba, Canada, we identified 34,316 women with baseline spine and hip DXA, FRAX-based fracture probability measurements (computed with femoral neck bone mineral density), lumbar spine TBS, and minimum 5 years of observation (mean 8...
March 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28274578/comparison-of-ct-rector-and-j-cto-scores-to-predict-chronic-total-occlusion-difficulty-for-percutaneous-coronary-intervention
#13
Yahang Tan, Jia Zhou, Wei Zhang, Ying Zhou, Luoshan Du, Feng Tian, Jun Guo, Lian Chen, Feng Cao, Yundai Chen
BACKGROUND: We sought to evaluate the ability of the CT-RECTOR and J-CTO scores to predict time-efficient guidewire (GW) crossing through a chronic total occlusion (CTO) and final procedure success. METHODS: Data from 191 consecutive CTO lesions with pre-procedural coronary computed tomography angiography (CCTA) from our center were analyzed retrospectively. The difficulty of the procedure was classified as easy, intermediate, difficult, or very difficult according to CT-RECTOR and J-CTO scores...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28268509/preliminary-imaging-results-and-sar-analysis-of-a-microwave-imaging-system-for-early-breast-cancer-detection
#14
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo
Currently X-ray-based imaging systems suffer from low contrast between malignant and healthy fibrous tissues in breast. Microwave Near-field Radar Imaging (NRI) shows a higher contrast between the aforementioned tissues and therefore can enhance tumor detection and diagnosis accuracy. In this work, we present the first imaging results of our developed NRI system that is equipped with a pair of Antipodal Vivaldi Antennas. We used a metal bearing ball immersed in oil as our object of interest, to keep the first measurement configuration simple...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28248067/evaluation-of-stenosis-severity-of-coronary-calcified-lesions-using-transluminal-attenuation-gradient-clinical-application-of-320-row-volume-ct
#15
Yang Fengfeng, Dong Jie, Wang Wei, Wang Xiuting, Fu Xiaojiao, Kumar C Nanda, Zhang Tong
BACKGROUND: To evaluate the accuracy of transluminal attenuation gradient (TAG) in diagnosing the stenosis degree of lesions of difficult to accurately assess the degree of luminal stenosis using coronary computed tomography angiography (CCTA). METHODS: A total of 130 patients consecutively received CCTA and coronary angiography (CAG). The average transluminal Hounsfield units (HU) of the regions of interest were consecutively measured at an interval of 5 mm from the ostium to the distal level, followed by the calculation of TAG...
March 1, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28239373/variations-of-soil-microbial-community-structures-beneath-broadleaved-forest-trees-in-temperate-and-subtropical-climate-zones
#16
Sihang Yang, Yuguang Zhang, Jing Cong, Mengmeng Wang, Mengxin Zhao, Hui Lu, Changyi Xie, Caiyun Yang, Tong Yuan, Diqiang Li, Jizhong Zhou, Baohua Gu, Yunfeng Yang
Global warming has shifted climate zones poleward or upward. However, understanding the responses and mechanism of microbial community structure and functions relevant to natural climate zone succession is challenged by the high complexity of microbial communities. Here, we examined soil microbial community in three broadleaved forests located in the Wulu Mountain (WLM, temperate climate), Funiu Mountain (FNM, at the border of temperate and subtropical climate zones), or Shennongjia Mountain (SNJ, subtropical climate)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28230181/dezocine-exhibits-antihypersensitivity-activities-in-neuropathy-through-spinal-%C3%AE-opioid-receptor-activation-and-norepinephrine-reuptake-inhibition
#17
Yong-Xiang Wang, Xiao-Fang Mao, Teng-Fei Li, Nian Gong, Ma-Zhong Zhang
Dezocine is the number one opioid painkiller prescribed and sold in China, occupying 44% of the nation's opioid analgesics market today and far ahead of the gold-standard morphine. We discovered the mechanisms underlying dezocine antihypersensitivity activity and assessed their implications to antihypersensitivity tolerance. Dezocine, given subcutaneously in spinal nerve-ligated neuropathic rats, time- and dose-dependently produced mechanical antiallodynia and thermal antihyperalgesia, significantly increased ipsilateral spinal norepinephrine and serotonin levels, and induced less antiallodynic tolerance than morphine...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28226683/preliminary-imaging-results-and-sar-analysis-of-a-microwave-imaging-system-for-early-breast-cancer-detection
#18
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ali Molaei, Ashkan Ghanbarzadeh Dagheyan, Jose Martinez-Lorenzo, Richard Obermeier
Currently X-ray-based imaging systems suffer from low contrast between malignant and healthy fibrous tissues in breast. Microwave Near-field Radar Imaging (NRI) shows a higher contrast between the aforementioned tissues and therefore can enhance tumor detection and diagnosis accuracy. In this work, we present the first imaging results of our developed NRI system that is equipped with a pair of Antipodal Vivaldi Antennas. We used a metal bearing ball immersed in oil as our object of interest, to keep the first measurement configuration simple...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220036/proposal-for-a-new-predictive-model-of-short-term-mortality-after-living-donor-liver-transplantation-due-to-acute-liver-failure
#19
COMPARATIVE STUDY
Hyun Sik Chung, Yu Jung Lee, Yun Sung Jo
BACKGROUND Acute liver failure (ALF) is known to be a rapidly progressive and fatal disease. Various models which could help to estimate the post-transplant outcome for ALF have been developed; however, none of them have been proved to be the definitive predictive model of accuracy. We suggest a new predictive model, and investigated which model has the highest predictive accuracy for the short-term outcome in patients who underwent living donor liver transplantation (LDLT) due to ALF. MATERIAL AND METHODS Data from a total 88 patients were collected retrospectively...
February 21, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28215493/comparison-of-nutritional-risk-scores-for-predicting-mortality-in-japanese-chronic-hemodialysis-patients
#20
Hiroshi Takahashi, Keiko Inoue, Kazue Shimizu, Keiko Hiraga, Erika Takahashi, Kaori Otaki, Taeko Yoshikawa, Kumiko Furuta, Chika Tokunaga, Tomoyo Sakakibara, Yasuhiko Ito
OBJECTIVE: Protein energy wasting (PEW) is consistently associated with poor prognosis in hemodialysis (HD) patients. We compared the predictability of PEW as diagnosed by The International Society of Renal Nutrition and Metabolism criteria (PEWISRNM) and geriatric nutritional risk index (GNRI) for all-cause mortality in Japanese HD patients. As cut-off values for body mass index (BMI) for PEW have not been established in PEWISRNM for Asian populations, these were also investigated. DESIGN AND SUBJECTS: The nutritional status from 409 HD patients was evaluated according to ISRNM and GNRI criteria...
May 2017: Journal of Renal Nutrition
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