keyword
MENU ▼
Read by QxMD icon Read
search

Integrated discrimination improvement

keyword
https://www.readbyqxmd.com/read/28520844/fracture-risk-assessment-with-frax-using-real-world-data-a-population-based-cohort-from-israel
#1
Inbal Goldshtein, Yariv Gerber, Sophia Ish-Shalom, Moshe Leshno
The predictive value of the WHO fracture risk assessment tool was evaluated using real-world community data. A population-based cohort of 141,320 women aged 50-90 years old (median age 58, inter quartile range (IQR): 54-67) at the year 2004 was extracted from the central database of a large Israeli healthcare services provider and insurer. Retrospective FRAX scores were calculated using computerized health records and compared to actual incident major osteoporotic fractures (MOF) during the following 10 years...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28513919/functional-status-and-mortality-prediction-in-community-acquired-pneumonia
#2
Kyeongman Jeon, Hongseok Yoo, Byeong-Ho Jeong, Hye Yun Park, Won-Jung Koh, Gee Young Suh, Eliseo Guallar
BACKGROUND AND OBJECTIVE: Poor functional status (FS) has been suggested as a poor prognostic factor in both pneumonia and severe pneumonia in elderly patients. However, it is still unclear whether FS is associated with outcomes and improves survival prediction in community-acquired pneumonia (CAP) in the general population. METHODS: Data on hospitalized patients with CAP and FS, assessed by the Eastern Cooperative Oncology Group (ECOG) scale were prospectively collected between January 2008 and December 2012...
May 17, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28511690/development-of-a-clinical-prediction-algorithm-for-knee-osteoarthritis-structural-progression-in-a-cohort-study-value-of-adding-measurement-of-subchondral-bone-density
#3
Michael P LaValley, Grace H Lo, Lori Lyn Price, Jeffrey B Driban, Charles B Eaton, Timothy E McAlindon
BACKGROUND: Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of including periarticular bone mineral density (BMD) in the algorithm. METHODS: Participants were from the Osteoarthritis Initiative (OAI) Progression Cohort, with X-ray readings of medial joint space at 36- and 48-month visits, and a 30- or 36-month medial-to-lateral tibial BMD ratio (M:L BMD ratio) value...
May 16, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28508538/prognostic-value-of-predialysis-indices-for-technique-failure-and-mortality-in-peritoneal-dialysis-patients
#4
Masaru Matsui, Yasuhiro Akai, Ken-Ichi Samejima, Hideo Tsushima, Kaori Tanabe, Katsuhiko Morimoto, Miho Tagawa, Yoshihiko Saito
Technique failure remains a frequent cause of peritoneal dialysis (PD) withdrawal. Many post-commencement predictors of PD technique failure have been identified, while predialysis predictors have remained unclear. The aim of this study was to identify predialysis indices for technique failure in PD patients. We recruited 206 consecutive PD patients who were treated at Nara Medical University Hospital between 1 April 1997 and 31 December 2012. Forty-eight patients were excluded because of transition from hemodialysis (HD) or withdrawal from PD within 3 months, leaving 158 patients for analysis...
May 15, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28499358/can-we-predict-functional-decline-in-hospitalized-older-people-admitted-through-the-emergency-department-reanalysis-of-a-predictive-tool-ten-years-after-its-conception
#5
Isabelle De Brauwer, Pascale Cornette, Benoît Boland, Franck Verschuren, William D'Hoore
BACKGROUND: In the Emergency Department (ED), early and rapid identification of older people at risk of adverse outcomes, who could best benefit from complex geriatric intervention, would avoid wasting time, especially in terms of prevention of adverse outcomes, and ensure optimal orientation of vulnerable patients. We wanted to test the predictive ability of a screening tool assessing risk of functional decline (FD), named SHERPA, 10 years after its conception, and to assess the added value of other clinical or biological factors associated with FD...
May 12, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28491011/an-integrated-proteomic-and-glycoproteomic-approach-uncovers-differences-in-glycosylation-occupancy-from-benign-and-malignant-epithelial-ovarian-tumors
#6
Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B S Roden, Hui Zhang, Daniel W Chan
BACKGROUND: Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. These glycoproteins on cell surface or shed into the bloodstream could serve as therapeutic targets as well as surrogates of tumor. In addition to glycoprotein expressions, the analysis of protein glycosylation occupancy could be important for the understanding of cancer biology as well as the identification of potential glycoprotein changes in cancer...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28490621/plasma-7-ketocholesterol-levels-and-the-risk-of-incident-cardiovascular-events
#7
Min Wang, Weiqing Long, Di Li, Duan Wang, Yuan Zhong, Di Mu, Jiayi Song, Min Xia
OBJECTIVE: 7-Ketocholesterol (7-KC), a major oxidation product of cholesterol, is found in human atherosclerotic plaque and more atherogenic than cholesterol in animal models. This study was designed to investigate the association of plasma 7-KC level with the incident cardiovascular disease (CVD) events in general population. METHODS: We measured plasma 7-KC concentrations at baseline in 1944 participants free from CVD in a community-based cohort study. The primary endpoint was incident of a major adverse cardiovascular event...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28485407/lipocalin-2-regulates-adult-neurogenesis-and-contextual-discriminative-behaviours
#8
A C Ferreira, T Santos, B Sampaio-Marques, A Novais, S D Mesquita, P Ludovico, L Bernardino, M Correia-Neves, N Sousa, J A Palha, J C Sousa, F Marques
In the adult mammalian brain, newborn granule cells are continuously integrated into hippocampal circuits, and the fine-tuning of this process is important for hippocampal function. Thus, the identification of factors that control adult neural stem cells (NSCs) maintenance, differentiation and integration is essential. Here we show that the deletion of the iron trafficking protein lipocalin-2 (LCN2) induces deficits in NSCs proliferation and commitment, with impact on the hippocampal-dependent contextual fear discriminative task...
May 9, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28481840/age-shock-index-is-superior-to-shock-index-and-modified-shock-index-for-predicting-long-term-prognosis-in-acute-myocardial-infarction
#9
Tongtong Yu, Chunyang Tian, Jia Song, Dongxu He, Zhijun Sun, Zhaoqing Sun
BACKGROUND: Shock index (SI) has been reported to help us predict adverse prognosis in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). However, the prognostic value of age SI and modified shock index (MSI) in AMI undergoing PCI is unknown. Moreover, the prognostic performance of admission age SI is not compared with SI, MSI and the Global Registry of Acute Coronary Events (GRACE) risk score. METHODS: 1,864 AMI patients undergoing PCI were analyzed in a retrospective cohort study...
May 5, 2017: Shock
https://www.readbyqxmd.com/read/28481809/vessel-masked-perfusion-magnetic-resonance-imaging-with-histogram-analysis-improves-diagnostic-accuracy-for-the-grading-of-glioma
#10
Atsuko Arisawa, Yoshiyuki Watanabe, Hisashi Tanaka, Hiroto Takahashi, Chisato Matsuo, Takuya Fujiwara, Yasunori Fujimoto, Kouji Yamamoto, Noriyuki Tomiyama
OBJECTIVE: Dynamic susceptibility contrast magnetic resonance imaging is widely used to assess glioma grade; histogram analyses are used for precise tumor perfusion evaluations. We evaluated the effect of vessel contamination in normalized cerebral blood volume (nCBV) to differentiate high- and low-grade gliomas. METHODS: Thirty-four patients with gliomas underwent dynamic susceptibility contrast magnetic resonance imaging. Both traditional and vessel-masked nCBV maps were constructed...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28479094/integrating-genotypes-in-the-same-tt2r2-score-for-the-prediction-of-anticoagulation-control-in-chinese-patients-with-atrial-fibrillation-on-warfarin
#11
Jia Liu, Nina Wang, Liuan Qin, Jun Liu, Shaozhi Xi, Xuyun Wang, Xiaoqi Li, Yuxiao Zhang, Tong Yin
INTRODUCTION: The SAMe-TT2R2 score has been proposed to predict whether patients with atrial fibrillation (AF) would be well anti-coagulated with warfarin or not. However, it might over-estimate the number of patients under suboptimal warfarin treatment in non-Caucasians. This study was designed to modify the SAMe-TT2R2 score with genotypes and validate it in Chinese AF patients treated with warfarin. MATERIAL AND METHODS: Consented Chinese-Han patients (n=510) with AF under the treatment of warfarin for at least 3months were randomly divided into a derivation (n=310) and a validation cohort (n=200)...
April 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28470755/simoni-smart-integrated-monitoring-as-a-novel-bioanalytical-strategy-for-water-quality-assessment-part-i-model-design-and-effect-based-trigger-values
#12
Ron van der Oost, Giulia Sileno, Maria Suárez-Muñoz, Mai Thao Nguyen, Harrie Besselink, Bram Brouwer
It is virtually impossible to reliably assess water quality with target chemical analyses only. Therefore, a complementary effect-based risk assessment is proposed here by bioanalyses on mixtures of bioavailable micropollutants: the Smart Integrated Monitoring (SIMONI) strategy. The goal of this strategy is to obtain more reliable information on the water quality to select optimum measures for improvement. The SIMONI strategy is two-tiered. Tier 1 is a bioanalytical hazard identification of sites. A tier 2 ecological risk assessment is carried out only at a limited number of sites where increased hazards are detected in tier 1...
May 4, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28467691/quality-of-life-amongst-women-in-bangladesh-following-ileal-conduit-urinary-diversion-operations-for-irreparable-vesicovaginal-fistula-and-bladder-exstrophy-observational-study
#13
Sarah H Walker, Beatrice Ambauen-Berger, Stacy L Saha, Sayeba Akhter
OBJECTIVE: To determine the quality of life (QOL) amongst fistula patients in Bangladesh, who have undergone Ileal Conduit (IC) urinary diversion operations, and to assess whether the risks and ethical challenges involved outweigh the reality of leaving a woman with urinary incontinence for the rest of her life. DESIGN: Observational study. SETTING: LAMB Hospital, Bangladesh. POPULATION: 17 women who had undergone IC between February 2012 and March 2016...
May 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28461232/a-comprehensive-statistical-classifier-of-foci-in-the-cell-transformation-assay-for-carcinogenicity-testing
#14
Giulia Callegaro, Kasja Malkoc, Raffaella Corvi, Chiara Urani, Federico M Stefanini
The identification of the carcinogenic risk of chemicals is currently mainly based on animal studies. The in vitro Cell Transformation Assays (CTAs) are a promising alternative to be considered in an integrated approach. CTAs measure the induction of foci of transformed cells. CTAs model key stages of the in vivo neoplastic process and are able to detect both genotoxic and some non-genotoxic compounds, being the only in vitro method able to deal with the latter. Despite their favorable features, CTAs can be further improved, especially reducing the possible subjectivity arising from the last phase of the protocol, namely visual scoring of foci using coded morphological features...
April 28, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28456521/visual-integration-enhances-associative-memory-equally-for-young-and-older-adults-without-reducing-hippocampal-encoding-activation
#15
Molly Memel, Lee Ryan
The ability to remember associations between previously unrelated pieces of information is often impaired in older adults (Naveh-Benjamin, 2000). Unitization, the process of creating a perceptually or semantically integrated representation that includes both items in an associative pair, attenuates age-related associative deficits (Bastin et al., 2013; Ahmad et al., 2015; Zheng et al., 2015). Compared to non-unitized pairs, unitized pairs may rely less on hippocampally-mediated binding associated with recollection, and more on familiarity-based processes mediated by perirhinal cortex (PRC) and parahippocampal cortex (PHC)...
April 26, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28448775/exploring-electronic-medical-record-and-self-administered-medication-risk-screening-tools-in-a-primary-care-clinic
#16
Mark J Makowsky, Ken Cor, Tat Wong
BACKGROUND: Electronic medical record (EMR) screening for indicators of medication risk could improve efficiency in identifying primary care clinic patients in need of clinical pharmacist care compared with patient self-reporting. OBJECTIVES: To (a) compare the performance of an EMR medication risk assessment questionnaire (MRAQ) with a self-administered (SA) MRAQ and (b) explore each tool's ability to predict indicators of health behavior, health status, and health care utilization...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448159/the-centrality-of-the-response-process-in-construct-validity-an-illustration-via-the-rorschach-space-response
#17
Joni L Mihura, Nicolae Dumitrascu, Manali Roy, Gregory J Meyer
Recently, psychologists have emphasized the response process-that is, the psychological operations and behaviors that lead to test scores-when designing psychological tests, interpreting their results, and refining their validity. To illustrate the centrality of the response process in construct validity and test interpretation, we provide a historical, conceptual, and empirical review of the main uses of the background white space of the Rorschach cards, called space reversal (SR) and space integration (SI) in the Rorschach Performance Assessment System...
April 27, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28442234/impact-of-restrictive-lung-disorder-on-cardiovascular-mortality-in-a-general-population-the-yamagata-takahata-study
#18
Yuki Honda, Tetsu Watanabe, Yoko Shibata, Yoichiro Otaki, Shinpei Kadowaki, Taro Narumi, Tetsuya Takahashi, Daisuke Kinoshita, Miyuki Yokoyama, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Sumito Inoue, Takuya Miyamoto, Tsuneo Konta, Ryo Kawasaki, Makoto Daimon, Takeo Kato, Yoshiyuki Ueno, Takamasa Kayama, Isao Kubota
BACKGROUND: Obstructive lung disorder (OLD) is known to be associated with cardiovascular disease. However, the impact of restrictive lung disorder (RLD) on cardiovascular mortality has not been fully investigated in the apparently healthy general population. OBJECTIVES: To clarify whether RLD is associated with cardiovascular mortality in the general population. METHODS AND RESULTS: This community-based cohort study included 3247 subjects who participated in an annual health check in Takahata...
April 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28441698/ambulatory-arterial-stiffness-index-and-its-role-in-assessing-arterial-stiffness-in-dialysis-patients
#19
Wenjin Liu, Jiajun Zhou, Jianping Chen, Meijuan Meng, Xiurong Li, Chaoqing Gao, Jianmei Zhou, Liang Wang, Zhuxing Sun, Hong Chu, Wei Fan, Youwei Bai, Junwei Yang
OBJECTIVE: Ambulatory arterial stiffness index (AASI) is a parameter derived from ambulatory blood pressure (ABP) readings. It is calculated as 1 minus the linear slope of DBP on SBP. We tested its value in assessing arterial stiffness in dialysis patients. METHODS: We performed a cross-sectional analysis of the baseline data from a cohort study. A total of 344 patients on maintenance hemodialysis from six tertiary hospitals were included. All patients underwent ABP monitoring and carotid-femoral pulse wave velocity (cfPWV) measurement...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28440083/systems-metabolomics-for-prediction-of-metabolic-syndrome
#20
Estelle Pujos-Guillot, Marion Brandolini, Mélanie Pétéra, Dhouha Grissa, Charlotte Joly, Bernard Lyan, Éléonore Herquelot, Sébastien Czernichow, Marie Zins, Marcel Goldberg, Blandine Comte
The evolution of human health is a continuum of transitions, involving multifaceted processes at multiple levels, and there is an urgent need for integrative biomarkers that can characterize and predict progression toward disease development. The objective of this work was to perform a systems metabolomics approach to predict metabolic syndrome (MetS) development. A case-control design was used within the French occupational GAZEL cohort (n = 112 males: discovery study; n = 94: replication/validation study)...
May 4, 2017: Journal of Proteome Research
keyword
keyword
30804
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"