keyword
MENU ▼
Read by QxMD icon Read
search

Integrated discrimination improvement

keyword
https://www.readbyqxmd.com/read/27927629/central-haemodynamics-and-prediction-of-cardiovascular-events-in-patients-with-erectile-dysfunction
#1
Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Rokkas, Athanassios Angelis, Dimitrios Terentes-Printzios, Zisis Kratiras, Christos Georgakopoulos, Dimitrios Tousoulis
BACKGROUND: We investigated whether central hemodynamics predict major adverse cardiovascular events (MACEs) in erectile dysfunction (ED) patients beyond traditional risk factors. METHODS: MACEs in relation to aortic pressures and augmentation index (AIx) were analyzed in 398 patients (mean age, 56 years) with ED but without established cardiovascular (CV) disease. RESULTS: During the mean follow-up period of 6.5 years, a total of 29 (6.5%) MACEs occurred...
December 7, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27926629/the-informativity-of-sound-modulates-crossmodal-facilitation-of-visual-discrimination-a-fmri-study
#2
Qi Li, Hongtao Yu, Xiujun Li, Hongzan Sun, Jingjing Yang, Chunlin Li
Many studies have investigated behavioral crossmodal facilitation when a visual stimulus is accompanied by a concurrent task-irrelevant sound. Lippert and colleagues reported that a concurrent task-irrelevant sound reduced the uncertainty of the timing of the visual display and improved perceptional responses (informative sound). However, the neural mechanism by which the informativity of sound affected crossmodal facilitation of visual discrimination remained unclear. In this study, we used event-related functional MRI to investigate the neural mechanisms underlying the role of informativity of sound in crossmodal facilitation of visual discrimination...
December 6, 2016: Neuroreport
https://www.readbyqxmd.com/read/27924061/the-relationship-between-serum-fibrosis-markers-and-restrictive-ventricular-filling-in-patients-with-heart-failure-with-reduced-ejection-fraction-a-technetium-99m-radionuclide-ventriculography-study
#3
Yen-Tin Lin, Yen-Hung Lin, Xue-Ming Wu, Chi-Lun Ko, Ruoh-Fang Yen, Ying-Hsein Chen, Ron-Bin Hsu, Chi-Ming Lee, Shoei-Shen Wang, Ming-Fong Chen, Yen-Wen Wu
Myocardial fibrosis leads to a restrictive diastolic filling pattern of the left ventricle which is associated with a poor prognosis in patients with heart failure. We investigated the relationship between cardiac fibrosis and restrictive filling pattern of the left ventricle measured by Tc99m left ventriculography in patients with chronic symptomatic heart failure. Serum cardiac extracellular matrix markers including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2,9 (MMP-2,9), and tissue inhibitor of MMP-1 (TIMP-1) were analyzed...
December 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27920547/predictive-value-of-nt-probnp-for-30-day-mortality-in-patients-with-non-st-elevation-acute-coronary-syndromes-a-comparison-with-the-grace-and-timi-risk-scores
#4
Dirk Aam Schellings, Ahmet Adiyaman, Jan-Henk E Dambrink, At Marcel Gosselink, Elvin Kedhi, Vincent Roolvink, Jan Paul Ottervanger, Arnoud Wj Van't Hof
BACKGROUND: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. PURPOSE: To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores in patients with NSTE-ACS...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27918886/computational-principles-and-models-of-multisensory-integration
#5
REVIEW
Chandramouli Chandrasekaran
Combining information from multiple senses creates robust percepts, speeds up responses, enhances learning, and improves detection, discrimination, and recognition. In this review, I discuss computational models and principles that provide insight into how this process of multisensory integration occurs at the behavioral and neural level. My initial focus is on drift-diffusion and Bayesian models that can predict behavior in multisensory contexts. I then highlight how recent neurophysiological and perturbation experiments provide evidence for a distributed redundant network for multisensory integration...
December 2, 2016: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/27914696/additional-predictive-value-of-nutritional-status-in-the-prognostic-assessment-of-heart-failure-patients
#6
M T La Rovere, R Maestri, F Olmetti, V Paganini, G Riccardi, R Riccardi, G D Pinna, E Traversi
BACKGROUND AND AIMS: Nutritional status (NS) is not routinely assessed in HF. We sought to evaluate whether NS may be additive to a comprehensive pre-discharge evaluation based on a clinical score that includes BMI (MAGGIC) and on an index of functional capacity (six minute walking test, 6mWT) in HF patients. METHODS AND RESULTS: The CONUT (Controlling Nutritional Status) score (including serum albumin level, total cholesterol and lymphocyte count) was computed in 466 consecutive patients (mean age 61 ± 11 years, NYHA class 2...
September 23, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27911825/elucidating-the-druggable-interface-of-protein-protein-interactions-using-fragment-docking-and-coevolutionary-analysis
#7
Fang Bai, Faruck Morcos, Ryan R Cheng, Hualiang Jiang, José N Onuchic
Protein-protein interactions play a central role in cellular function. Improving the understanding of complex formation has many practical applications, including the rational design of new therapeutic agents and the mechanisms governing signal transduction networks. The generally large, flat, and relatively featureless binding sites of protein complexes pose many challenges for drug design. Fragment docking and direct coupling analysis are used in an integrated computational method to estimate druggable protein-protein interfaces...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27904903/prediction-of-severe-bleeding-after-coronary-surgery-the-will-bleed-risk-score
#8
Fausto Biancari, Debora Brascia, Francesco Onorati, Daniel Reichart, Andrea Perrotti, Vito G Ruggieri, Giuseppe Santarpino, Daniele Maselli, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Eeva-Maija Kinnunen, Juhani K E Airaksinen, Paola D'Errigo, Stefano Rosato, Francesco Nicolini
Severe perioperative bleeding after coronary artery bypass grafting (CABG) is associated with poor outcome. An additive score for prediction of severe bleeding was derived (n=2494) and validated (n=1250) in patients from the E-CABG registry. Severe bleeding was defined as E-CABG bleeding grades 2-3 (transfusion of >4 units of red blood cells or reoperation for bleeding). The overall incidence of severe bleeding was 6.4 %. Preoperative anaemia (3 points), female gender (2 points), eGFR <45 ml/min/1.73 m(2) (3 points), potent antiplatelet drugs discontinued less than five days (2 points), critical preoperative state (5 points), acute coronary syndrome (2 points), use of low-molecular-weight heparin/fondaparinux/unfractionated heparin (1 point) were independent predictors of severe bleeding...
December 1, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27903539/outcome-implication-of-aortic-valve-area-normalized-to-body-size-in-asymptomatic-aortic-stenosis
#9
Christophe Tribouilloy, Yohann Bohbot, Sylvestre Maréchaux, Nicolas Debry, Quentin Delpierre, Marcel Peltier, Momar Diouf, Michel Slama, David Messika-Zeitoun, Dan Rusinaru
BACKGROUND: Current guidelines define severe aortic stenosis in patients with aortic valve area normalized to body surface area (AVA/BSA) <0.6 cm(2)/m(2); yet, this cutoff has never been validated. Moreover, it is not known whether AVA normalization to other body size indexes allows improved outcome prediction. We aim to test the value of AVA normalized to body size for outcome prediction in asymptomatic aortic stenosis. METHODS AND RESULTS: We included 289 patients with asymptomatic aortic stenosis, preserved ejection fraction, and AVA<1...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27900999/evaluating-anti-smd1-amino-acid-83-119-peptide-reactivity-in-children-with-systemic-lupus-erythematosus-and-other-immunological-diseases
#10
Hai-Ou Yang, Xiao-Qing Zhang, Qi-Hua Fu
BACKGROUND: SmD1-amino-acid 83-119 peptide (SmD183-119) is the major epitope of Smith (Sm) antigen, which is specific for adult systemic lupus erythematosus (SLE). The anti-SmD183-119 antibody has exhibited higher sensitivity and specificity than anti-Sm antibody in diagnosing adult SLE. However, the utility of anti-SmD183-119antibodies remains unclear in children with SLE (cSLE). This study aimed to assess the characteristics of anti-SmD183-119antibody in the diagnosis of cSLE. METHODS: Samples from 242 children with different rheumatological and immunological disorders, including autoimmune diseases (SLE [n = 46] and ankylosing spondylitis [AS, n = 11]), nonautoimmune diseases (Henoch-Schonlein purpura [HSP, n = 60], idiopathic thrombocytopenia purpura [n = 27], hematuria [n = 59], and arthralgia [n = 39]) were collected from Shanghai Children's Medical Center from March 6, 2012 to February 27, 2014...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27888171/clinical-relevance-of-the-first-domomedicine-platform-securing-multidrug-chronotherapy-delivery-in-metastatic-cancer-patients-at-home-the-incasa-european-project
#11
Pasquale F Innominato, Sandra Komarzynski, Ali Mohammad-Djafari, Alexandre Arbaud, Ayhan Ulusakarya, Mohamed Bouchahda, Mazen Haydar, Rachel Bossevot-Desmaris, Virginie Plessis, Magali Mocquery, Davina Bouchoucha, Mehran Afshar, Jacques Beau, Abdoulaye Karaboué, Jean-François Morère, Joanna Fursse, Jordi Rovira Simon, Francis Levi
BACKGROUND: Telehealth solutions can improve the safety of ambulatory chemotherapy, contributing to the maintenance of patients at their home, hence improving their well-being, all the while reducing health care costs. There is, however, need for a practicable multilevel monitoring solution, encompassing relevant outputs involved in the pathophysiology of chemotherapy-induced toxicity. Domomedicine embraces the delivery of complex care and medical procedures at the patient's home based on modern technologies, and thus it offers an integrated approach for increasing the safety of cancer patients on chemotherapy...
November 25, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27881564/heart-failure-stages-among-older-adults-in-the-community-the-atherosclerosis-risk-in-communities-study
#12
Amil M Shah, Brian Claggett, Laura R Loehr, Patricia P Chang, Kunihiro Matsushita, Dalane Kitzman, Suma H Konety, Anna Kucharska-Newton, Carla A Sueta, Thomas H Mosley, Jacqueline D Wright, Josef Coresh, Gerardo Heiss, Aaron R Folsom, Scott D Solomon
BACKGROUND: -Although HF disproportionately affects older adults, little data exist regarding the prevalence of American College of Cardiology/American Heart Association heart failure (HF) stages among older individuals in the community. Additionally, the role of contemporary measures of longitudinal strain (LS) and diastolic dysfunction in defining HF stages is unclear. METHODS: -HF stages were classified in 6,118 participants in the Atherosclerosis Risk in Communities study (age 67 - 91 years) at the fifth study visit as follows: stage A (asymptomatic with HF risk factors but no cardiac structural or functional abnormalities), B (asymptomatic with structural abnormalities, defined as left ventricular hypertrophy, dilation or dysfunction, or significant valvular disease), C1 (clinical HF without prior hospitalization), and C2 (clinical HF with prior hospitalization)...
November 23, 2016: Circulation
https://www.readbyqxmd.com/read/27879323/issues-and-challenges-in-diagnostic-sequencing-for-inherited-cardiac-conditions
#13
REVIEW
Roddy Walsh, Stuart A Cook
BACKGROUND: Inherited cardiac conditions are a relatively common group of Mendelian diseases associated with ill health and death, often in the young. Research into the genetic causes of these conditions has enabled confirmatory and predictive diagnostic sequencing to become an integral part of the clinical management of inherited cardiomyopathies, arrhythmias, aortopathies, and dyslipidemias. CONTENT: Currently, the principle benefit of clinical genetic testing is the cascade screening of family members of patients with a pathogenic variant, enabling targeted follow up of presymptomatic genotype-positive individuals and discharge of genotype-negative individuals to health...
November 22, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27879297/addressing-the-mental-health-needs-of-latino-children-in-immigrant-families
#14
Tania Maria Caballero, Lisa Ross DeCamp, Rheanna E Platt, Harita Shah, Sara B Johnson, Erica M S Sibinga, Sarah Polk
Latino children in the United States, whether immigrants themselves or children in immigrant families, are at high risk for mental health disorders stemming from poverty, exposure to trauma, assimilation stressors, and discrimination. The timely identification and treatment of mental health disorders in Latino children are compromised by limited healthcare access and quality as well as the lack of routine mental health screening in pediatric primary care. Here we review Spanish-language validity and implementation studies of Bright Futures previsit mental health screening tools and models of care...
November 21, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27872790/kansas-city-cardiomyopathy-questionnaire-utility-in-prediction-of-30-day-readmission-rate-in-patients-with-chronic-heart-failure
#15
Shengchuan Dai, Manoucher Manoucheri, Junhong Gui, Xiang Zhu, Divyanshu Malhotra, Shenjing Li, Jason D'souza, Fnu Virkram, Aditya Chada, Haibing Jiang
Background. Heart failure (HF) is one of the most common diagnoses associated with hospital readmission. We designed this prospective study to evaluate whether Kansas City Cardiomyopathy Questionnaire (KCCQ) score is associated with 30-day readmission in patients hospitalized with decompensated HF. Methods and Results. We enrolled 240 patients who met the study criteria. Forty-eight (20%) patients were readmitted for decompensated HF within thirty days of hospital discharge, and 192 (80%) patients were not readmitted...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27867804/dfast-and-daga-web-based-integrated-genome-annotation-tools-and-resources
#16
Yasuhiro Tanizawa, Takatomo Fujisawa, Eli Kaminuma, Yasukazu Nakamura, Masanori Arita
Quality assurance and correct taxonomic affiliation of data submitted to public sequence databases have been an everlasting problem. The DDBJ Fast Annotation and Submission Tool (DFAST) is a newly developed genome annotation pipeline with quality and taxonomy assessment tools. To enable annotation of ready-to-submit quality, we also constructed curated reference protein databases tailored for lactic acid bacteria. DFAST was developed so that all the procedures required for DDBJ submission could be done seamlessly online...
2016: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/27851788/dietary-information-improves-model-performance-and-predictive-ability-of-a-noninvasive-type-2-diabetes-risk-model
#17
Tianshu Han, Shuang Tian, Li Wang, Xi Liang, Hongli Cui, Shanshan Du, Guanqiong Na, Lixin Na, Changhao Sun
There is no diabetes risk model that includes dietary predictors in Asia. We sought to develop a diet-containing noninvasive diabetes risk model in Northern China and to evaluate whether dietary predictors can improve model performance and predictive ability. Cross-sectional data for 9,734 adults aged 20-74 years old were used as the derivation data, and results obtained for a cohort of 4,515 adults with 4.2 years of follow-up were used as the validation data. We used a logistic regression model to develop a diet-containing noninvasive risk model...
2016: PloS One
https://www.readbyqxmd.com/read/27832202/helicobacter-pylori-seropositivity-in-patients-with-interleukin-1-polymorphisms-is-significantly-associated-with-st-segment-elevation-myocardial-infarction
#18
Noriaki Tabata, Daisuke Sueta, Tomonori Akasaka, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
BACKGROUND: Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome patients. METHODS: We recruited consecutive acute coronary syndrome patients, and 101 non-ST-segment elevation acute coronary syndrome patients and 103 ST-segment elevation myocardial infarction patients were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27829460/renal-function-estimation-and-cockroft-gault-formulas-for-predicting-cardiovascular-mortality-in-population-based-cardiovascular-risk-heart-failure-and-post-myocardial-infarction-cohorts-the-heart-omics-in-ageing-homage-and-the-high-risk-myocardial-infarction
#19
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A Pfeffer, John J V McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J Wouter Jukema, John G Cleland, Faiez Zannad, Patrick Rossignol
BACKGROUND: Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease Study (MDRD4), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The CKD-EPI is the most accurate eGFR estimator as compared to a "gold-standard"; however, which of the latter is the best formula to assess prognosis remains to be clarified...
November 10, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27829345/predicting-drug-target-interactions-with-neighbor-interaction-information-and-discriminative-low-rank-representation
#20
Lihong Peng, Bo Liao, Wen Zhu, Zejun Li
Inferring drug-target interaction (DTI) candidates for new drugs or targets without any interaction information is a critical challenge for modern drug design and discovery. A few approaches are applied to solve this problem. Results from these applications indicate that the existing DTI inference methods necessitate further improvement. The sparse, low-rank, and nonnegative properties of a known DTI matrix prompted us to design a novel DTI identification model ( i.e, PreNNDS ) by integrating known neighbor interaction profiles, nonnegative matrix factorization, discriminative low-rank representation, and sparse representation classification into a unified framework...
November 7, 2016: Current Protein & Peptide Science
keyword
keyword
30804
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"