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Integrated discrimination improvement

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https://www.readbyqxmd.com/read/28917730/direct-and-comprehensive-analysis-of-dyes-based-on-integrated-molecular-and-structural-information-via-laser-desorption-laser-postionization-mass-spectrometry
#1
Rong Liu, Zhibin Yin, Yixin Leng, Wei Hang, Benli Huang
Laser desorption laser postionization time-of-flight mass spectrometry (LDPI-TOFMS) was employed for direct analysis and determination of typical basic dyes. It was also used for the analysis and comprehensive understanding of complex materials such as blue ballpoint pen inks. Simultaneous emergences of fragmental and molecular information largely simplify and facilitate unambiguous identification of dyes via variable energy of 266nm postionization laser. More specifically, by optimizing postionization laser energy with the same energy of desorption laser, the structurally significant results show definite differences in the fragmentation patterns, which offer opportunities for discrimination of isomeric species with identical molecular weight...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916874/development-of-cacta-transposon-derived-scar-markers-and-their-use-in-population-structure-analysis-in-zea-mays
#2
Neha Samir Roy, Kyong-Cheul Park, Sung-Il Lee, Min-Ji Im, Rahul Vasudeo Ramekar, Nam-Soo Kim
Molecular marker technologies have proven to be an important breakthrough for genetic studies, construction of linkage maps and population genetics analysis. Transposable elements (TEs) constitute major fractions of repetitive sequences in plants and offer a wide range of possible areas to be explored as molecular markers. Sequence characterized amplified region (SCAR) marker development provides us with a simple and time saving alternative approach for marker development. We employed the CACTA-TD to develop SCARs and then integrated them into linkage map and used them for population structure and genetic diversity analysis of corn inbred population...
September 15, 2017: Genetica
https://www.readbyqxmd.com/read/28915810/does-one-workshop-on-respecting-cultural-differences-increase-health-professionals-confidence-to-improve-the-care-of-australian-aboriginal-patients-with-cancer-an-evaluation
#3
Angela Durey, Georgia Halkett, Melissa Berg, Leanne Lester, Marion Kickett
BACKGROUND: Aboriginal Australians have worse cancer survival rates than other Australians. Reasons include fear of a cancer diagnosis, reluctance to attend mainstream health services and discrimination from health professionals. Offering health professionals education in care focusing on Aboriginal patients' needs is important. The aim of this paper was to evaluate whether participating in a workshop improved the confidence of radiation oncology health professionals in their knowledge, communication and ability to offer culturally safe healthcare to Aboriginal Australians with cancer...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28912299/the-test-your-memory-for-mild-cognitive-impairment-tym-mci
#4
Jeremy M Brown, Claire J Lansdall, Julie Wiggins, Kate E Dawson, Kristina Hunter, James B Rowe, Richard A Parker
BACKGROUND: To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). METHODS: Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28904038/facilitated-access-to-an-integrated-model-of-care-for-arthritis-in-an-urban-aboriginal-population
#5
Cheryl Barnabe, Stacy Lockerbie, Elizabeth Erasmus, Lynden Crowshoe
OBJECTIVE: To evaluate a model of care to improve arthritis detection and treatment in an urban Aboriginal population. DESIGN: Cohort study. SETTING: The Elbow River Healing Lodge in Calgary, Alta. PARTICIPANTS: A total of 26 participants with noninflammatory arthritis and 12 with inflammatory arthritis. INTERVENTION: A monthly rheumatology clinic was embedded in the primary health care service and received referrals from primary care providers and allied health care professionals, or self-referrals...
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28900070/item-development-process-and-analysis-of-50-case-based-items-for-implementation-on-the-korean-nursing-licensing-examination
#6
In Sook Park, Yeon Ok Suh, Hae Sook Park, So Young Kang, Kwang Sung Kim, Gyung Hee Kim, Yeon-Hee Choi, Hyun-Ju Kim
Purpose: The purpose of this study was to improve the quality of items on the Korean Nursing Licensing Examination by developing and evaluating case-based items that reflect integrated nursing knowledge. Methods: We conducted a cross-sectional observational study to develop new case-based items. The methods for developing test items included expert workshops, brainstorming, and verification of content validity. After a mock examination of undergraduate nursing students using the newly developed case-based items, we evaluated the appropriateness of the items through classical test theory and item response theory...
September 11, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28894658/prioritization-for-plastic-surgery-procedures-aimed-to-improve-quality-of-life-moral-considerations
#7
Gennaro Selvaggi, Lars Kolby, Anna Elander
BACKGROUND: Different health conditions are treated in a Plastic Surgery unit, including those cases whose main goal is to enable patients to feel and integrate better within society and therefore improving quality of life, rather then physical functions. METHODS: We discuss moral principles that can be used as a guide for health professionals to revise and create policies for plastic surgery patients presenting with non-life-threatening conditions. RESULTS: A specific anatomical feature is not always an indicator of patient's well-being and quality of life, and therefore it cannot be used as the sole parameter to identify the worst-off and prioritize the provision of health care...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28889981/visual-vestibular-conflict-detection-depends-on-fixation
#8
Isabelle T Garzorz, Paul R MacNeilage
Visual and vestibular signals are the primary sources of sensory information for self-motion. Conflict among these signals can be seriously debilitating, resulting in vertigo [1], inappropriate postural responses [2], and motion, simulator, or cyber sickness [3-8]. Despite this significance, the mechanisms mediating conflict detection are poorly understood. Here we model conflict detection simply as crossmodal discrimination with benchmark performance limited by variabilities of the signals being compared. In a series of psychophysical experiments conducted in a virtual reality motion simulator, we measure these variabilities and assess conflict detection relative to this benchmark...
September 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28888270/soluble-endothelial-cell-selective-adhesion-molecule-and-incident-cardiovascular-events-in-a-multiethnic-population
#9
Hao-Yu Ren, Amit Khera, James A de Lemos, Colby R Ayers, Anand Rohatgi
BACKGROUND: Cell adhesion molecules are key regulators of atherosclerotic plaque development, but circulating levels of soluble fragments, such as intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1), have yielded conflicting associations with atherosclerotic cardiovascular disease (ASCVD). Endothelial cell-selective adhesion molecule (ESAM) is expressed exclusively in platelets and endothelial cells, and soluble ESAM (sESAM) levels have been associated with prevalent subclinical atherosclerosis...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28871544/calorespirometry-a-novel-tool-in-functional-hologenomics-to-select-green-holobionts-for-biomass-production
#10
Birgit Arnholdt-Schmitt, Vinod Kumar Patil
Endophytes can diversify temperature response and biomass production in plants and microalgae. Natural and inoculated endophytes that modify growth performance are increasingly considered in research and practical initiatives for sustainable agriculture. However, efficient, novel tools are required that are able to support identification of differential effects of native endophyte populations and for pre-selection of inocula.This protocol gives instructions for applying calorespirometry as a rapid means for identifying differential effects of endophytes on temperature response and predicted biomass productivity in microalgae and plant holobionts...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28862939/left-atrial-size-and-long-term-risk-of-recurrent-stroke-after-acute-ischemic-stroke-in-patients-with-nonvalvular-atrial-fibrillation
#11
Toshiyasu Ogata, Ryu Matsuo, Fumi Kiyuna, Jun Hata, Tetsuro Ago, Yoshio Tsuboi, Takanari Kitazono, Masahiro Kamouchi
BACKGROUND: Among patients with ischemic stroke and atrial fibrillation, which ones are at high risk of recurrent stroke is unclear. This study aimed to determine whether left atrial size was associated with long-term risk of stroke recurrence in patients with nonvalvular atrial fibrillation. METHODS AND RESULTS: In this multicenter prospective cohort study, nonvalvular atrial fibrillation patients hospitalized for acute ischemic stroke were enrolled and followed up after discharge...
August 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28860020/triplex-hrm-assay-for-the-simultaneous-assessment-of-il28b-rs12979860-abcb11-rs2287622-and-rnf7-rs16851720-genotypes-in-chronic-hepatitis-c-patients
#12
Elena Luminita Enache, Anca Sin, Liviu Sorin Enache, Ligia Bancu
Chronic hepatitis C (CHC) is a leading cause of liver disease. Despite the improved efficacy of new antivirals, their high costs preclude their adoption in resource-limited settings, where CHC prevalence is highest. We developed a triplex high resolution melting assay for the simultaneous assessment of three genetic polymorphisms related to the response to treatment and development of advanced fibrosis in CHC: IL28B rs12979860, ABCB11 rs2287622, and RNF7 rs16851720. We validated the assay in clinical samples from 130 CHC patients treated with classical therapy...
August 28, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28858802/structure-regularized-compressive-tracking-with-online-data-driven-sampling
#13
Qing Guo, Wei Feng, Ce Zhou, Chi-Man Pun, Bin Wu
Being a powerful appearance model, compressive random projection derives effective Haar-like features from nonrotated 4D-parameterized rectangles, thus supports fast and reliable object tracking. In this paper, we show that such successful fast compressive tracking (FCT) scheme can be further significantly improved by structural regularization and online data-driven sampling. Our major contribution is three-fold. First, we find that superpixel-guided compressive projection can generate more discriminative features by sufficiently capturing rich local structural information of images...
August 25, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28858220/a-hybrid-approach-to-detect-driver-drowsiness-utilizing-physiological-signals-to-improve-system-performance-and-wearability
#14
Muhammad Awais, Nasreen Badruddin, Micheal Drieberg
Driver drowsiness is a major cause of fatal accidents, injury, and property damage, and has become an area of substantial research attention in recent years. The present study proposes a method to detect drowsiness in drivers which integrates features of electrocardiography (ECG) and electroencephalography (EEG) to improve detection performance. The study measures differences between the alert and drowsy states from physiological data collected from 22 healthy subjects in a driving simulator-based study. A monotonous driving environment is used to induce drowsiness in the participants...
August 31, 2017: Sensors
https://www.readbyqxmd.com/read/28858153/attenuation-coefficients-from-sd-oct-data-structural-information-beyond-morphology-on-rnfl-integrity-in-glaucoma
#15
Gijs Thepass, Hans G Lemij, Koenraad A Vermeer
PURPOSE: To explore the attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL) in spectral domain optical coherence tomography (OCT) images, in healthy eyes and eyes affected by glaucoma. To assess the relation between RNLF AC, disease severity, RNFL thickness, visual field sensitivity threshold, spatial location and age. PATIENTS AND METHODS: We analyzed peripapillary circle scans of a clinical OCT device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) in 102 glaucoma patients and 90 healthy controls...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28856588/whole-blood-microrna-markers-are-associated-with-acute-respiratory-distress-syndrome
#16
Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A Baccarelli, Xi Zhu, Ednan K Bajwa, B Taylor Thompson, Guo-Ping Shi, David C Christiani
BACKGROUND: MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS. METHODS: This nested case-control study (N = 530) examined a cohort of ARDS patients and critically ill at-risk controls. Whole blood miRNA profiles and logistic regression analyses identified miRNAs correlated with ARDS...
August 30, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28855957/discrimination-of-boron-tolerance-in-pisum-sativum-l-genotypes-using-a-rapid-high-throughput-hydroponic-screen-and-precociously-germinated-seed-grown-under-far-red-enriched-light
#17
Richard G Bennett, Federico M Ribalta, Maria Pazos-Navarro, Antonio Leonforte, Janine S Croser
BACKGROUND: Boron (B) tolerance has been identified as a key target for field pea improvement. Screening for B tolerance in the field is problematic due to variability in space and time, and robust B molecular markers are currently unavailable in field pea. There has been recent progress in developing protocols that can accelerate the life cycle of plants to enable rapid generation turnover in single seed descent breeding programs. A robust B screening protocol that can be fully integrated within an accelerated single seed descent system could lead to rapid identification and introgression of B tolerance into field pea genotypes...
2017: Plant Methods
https://www.readbyqxmd.com/read/28851702/identification-of-novel-circulating-biomarkers-predicting-rapid-decline-in-renal-function-in-type-2-diabetes-the-fremantle-diabetes-study-phase-ii
#18
Kirsten E Peters, Wendy A Davis, Jun Ito, Kaye Winfield, Thomas Stoll, Scott D Bringans, Richard J Lipscombe, Timothy M E Davis
OBJECTIVE: To assess the ability of plasma apolipoprotein (apo) A-IV (apoA4), apo C-III, CD5 antigen-like (CD5L), complement C1q subcomponent subunit B (C1QB), complement factor H-related protein 2, and insulin-like growth factor binding protein 3 (IBP3) to predict rapid decline in estimated glomerular filtration rate (eGFR) in type 2 diabetes. RESEARCH DESIGN AND METHODS: Mass spectrometry was used to measure baseline biomarkers in 345 community-based patients (mean age 67...
August 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28844785/the-new-measuring-multimorbidity-index-predicted-mortality-better-than-charlson-and-elixhauser-indices-amongst-the-general-population
#19
James Stanley, Diana Sarfati
OBJECTIVE: To develop and validate an updated morbidity index for short-term mortality risk, using chronic conditions identified from routine hospital admission ICD-10 data. STUDY DESIGN AND SETTING: Retrospective cohort study of all adult New Zealand (NZ) residents at 1st Jan 2012. PARTICIPANTS: Adult NZ residents aged 18 and over, defined by enrolment with a Primary Healthcare Organisation or accessing public healthcare in preceding year...
August 24, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28844515/relation-of-carotid-intima-media-thickness-to-cardiovascular-events-in-black-americans-from-the-jackson-heart-study
#20
Todd C Villines, Lucy L Hsu, Chad Blackshear, Cheryl R Nelson, Michael Griswold
Although several prospective studies have reported independent relations between carotid intima-media thickness (CIMT) and risk of incident cardiovascular diseases (CVD) in primarily non-African-American (AA) cohorts, the utility of CIMT values for the prediction of incident coronary heart disease and stroke events in blacks remain unclear. At the baseline examination (2000 to 2004) of the Jackson Heart Study, AA adults 21 to 94 years of age (mean 54) underwent bilateral far-wall CIMT measurement (mean 0.76 mm)...
July 31, 2017: American Journal of Cardiology
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