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Integrated discrimination improvement

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https://www.readbyqxmd.com/read/28333038/detecting-colorectal-cancer-using-electrical-impedance-spectroscopy-an-ex-vivo-feasibility-study
#1
Angela Pathiraja, Paul Ziprin, Arsam Shiraz, Reza Mirnezami, Andrew Tizzard, Brian Brown, Andreas Demosthenous, Richard H Bayford
OBJECTIVE: Colorectal cancer is the fourth most common cancer worldwide, with a lifetime risk of around 20%. Current solutions do not allow clinicians to objectively assess tissue abnormality during endoscopy and perioperatively. A solution capable of objectively assessing samples in real time could greatly improve the treatment process. A solution that can be integrated in minimally invasive diagnostics and management strategies to provide real-time point-of-care information would be greatly transformative...
March 23, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28330665/quantitative-pericardial-delayed-hyperenhancement-informs-clinical-course-in-recurrent-pericarditis
#2
Arnav Kumar, Kimi Sato, Edlira Yzeiraj, Jorge Betancor, Lin Lin, Balaji K Tamarappoo, Deborah H Kwon, Rory Hachamovitch, Allan L Klein
OBJECTIVES: The aim of this study was to evaluate the prognostic value of quantitative assessment of pericardial delayed hyperenhancement (DHE) among patients with recurrent pericarditis (RP). BACKGROUND: Pericardial DHE on cardiac magnetic resonance may persist beyond the acute phase of pericarditis, suggesting continued pericardial inflammation. METHODS: This is a retrospective cohort study of 159 patients with RP who underwent DHE imaging and had a follow-up period of more than 6 months...
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28320663/iterative-re-constrained-group-sparse-face-recognition-with-adaptive-weights-learning
#3
Jianwei Zheng, Ping Yang, Shengyong Chen, Guojiang Shen, Wanliang Wang
In this paper, we consider the robust face recognition problem via iterative re-constrained group sparse classifier with adaptive weights learning (IRGSC). Specifically, we propose a group sparse representation classification (GSRC) approach in which weighted features and groups are collaboratively adopted to encode more structure information and discriminative information than other regression based methods. In addition, we derive an efficient algorithm to optimize the proposed objective function, and theoretically prove the convergence...
March 13, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28319004/updated-risk-factors-should-be-used-to-predict-development-of-diabetes
#4
Mary Angelyn Bethel, Kristen A Hyland, Antonio R Chacra, Prakash Deedwania, Gregory R Fulcher, Rury R Holman, Trond Jenssen, Naomi S Levitt, John J V McMurray, Eleni Boutati, Laine Thomas, Jie-Lena Sun, Steven M Haffner
AIMS: Predicting incident diabetes could inform treatment strategies for diabetes prevention, but the incremental benefit of recalculating risk using updated risk factors is unknown. We used baseline and 1-year data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial to compare diabetes risk prediction using historical or updated clinical information. METHODS: Among non-diabetic participants reaching 1year of follow-up in NAVIGATOR, we compared the performance of the published baseline diabetes risk model with a "landmark" model incorporating risk factors updated at the 1-year time point...
March 2, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28314798/insulin-like-growth-factor-binding-protein-4-fragments-provide-incremental-prognostic-information-on-cardiovascular-events-in-patients-with-st-segment-elevation-myocardial-infarction
#5
Rikke Hjortebjerg, Søren Lindberg, Sune Pedersen, Rasmus Mogelvang, Jan S Jensen, Claus Oxvig, Jan Frystyk, Mette Bjerre
BACKGROUND: Fragments of insulin-like growth factor binding protein 4 (IGFBP-4) are potential new biomarkers for cardiac risk assessment. The fragments are generated on specific cleavage by pregnancy-associated plasma protein-A, which exerts proatherogenic activity. This study investigated the prognostic value of IGFBP-4 fragments in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS: We prospectively included 656 patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention from September 2006 to December 2008...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28295386/an-integrated-segmentation-and-shape-based-classification-scheme-for-distinguishing-adenocarcinomas-from-granulomas-on-lung-ct
#6
Mehdi Alilou, Niha Beig, Mahdi Orooji, Anant Madabhushi, Prabhakar Rajiah, Michael Yang, Robert Gilkeson, Philip Linden, Vamsidhar Velcheti, Sagar Rakshit, Niyoti Reddy, Frank Jacono
PURPOSE: Distinguishing between benign granulmoas and adenocarcinomas is confounded by their similar visual appearance on routine CT scans. Unfortunately, owing to the inability to discriminate these lesions radigraphically, many patients with benign granulomas are subjected to unnecessary surgical wedge resections and biopsies for pathologic confirmation of cancer presence or absence. This suggests the need for improved computerized characterization of these nodules in order to distinguish between these two classes of lesions on CT scans...
March 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28284500/combined-baseline-and-one-month-changes-in-big-endothelin-1-and-brain-natriuretic-peptide-plasma-concentrations-predict-clinical-outcomes-in-patients-with-left-ventricular-dysfunction-after-acute-myocardial-infarction-insights-from-the-eplerenone-post-acute
#7
A Olivier, N Girerd, J B Michel, J M Ketelslegers, R Fay, J Vincent, P Bramlage, B Pitt, F Zannad, P Rossignol
OBJECTIVE: Increased levels of neuro-hormonal biomarkers predict poor prognosis in patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD). The predictive value of repeated (one-month interval) brain natriuretic peptides (BNP) and big-endothelin 1 (BigET-1) measurements were investigated in patients with LVSD after AMI. METHODS: In a sub-study of the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS trial), BNP and BigET-1 were measured at baseline and at 1month in 476 patients...
February 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28284134/development-and-validation-of-a-bacteria-based-index-of-biotic-integrity-for-assessing-the-ecological-status-of-urban-rivers-a-case-study-of-qinhuai-river-basin-in-nanjing-china
#8
Jie Li, Yi Li, Bao Qian, Lihua Niu, Wenlong Zhang, Wei Cai, Hainan Wu, Peifang Wang, Chao Wang
With the increasing human disturbance to urban rivers, the extinction and biodiversity losses of some macroorganism species decreased the accuracy of bioassessment. In this study, a novel index of biotic integrity based on bacteria (Ba-IBI) was first developed for Qinhuai River in Nanjing city, China. Thirty-two biofilm samples were collected along the river bank and the bacterial communities were identified by high-throughput sequencing. By the range, responsive, and redundancy tests, four core metrics were selected from the dataset of 78 candidate metrics, including Pielou's evenness index, proportion of Paenibacillus, proportion of OTUs tolerant to organic pollution and proportion of Nitrosomonas...
March 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28280088/radiomics-features-of-multiparametric-mri-as-novel-prognostic-factors-in-advanced-nasopharyngeal-carcinoma
#9
Shuixing Zhang, Bin Zhang, Jie Tian, Di Dong, Dong Sheng Gu, Yu Hao Dong, Lu Zhang, Zhou Yang Lian, Jing Liu, Xiao Ning Luo, Shu Fang Pei, Xiao Kai Mo, Wen Hui Huang, Fu Sheng Ouyang, Bao Liang Guo, Long Liang, Wenbo Chen, Chang H Liang
PURPOSE: To identify MRI-based radiomics as prognostic factors in patients with advanced nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN: One-hundred and eighteen patients (training cohort: n = 88; validation cohort: n = 30) with advanced NPC were enrolled. A total of 970 radiomics features were extracted from T2-weighted (T2-w) and contrast-enhanced T1-weighted (CET1-w) MRI. Least absolute shrinkage and selection operator (LASSO) regression was applied to select features for progression-free survival (PFS) nomograms...
March 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28280039/pathway-specific-aggregate-biomarker-risk-score-is-associated-with-burden-of-coronary-artery-disease-and-predicts-near-term-risk-of-myocardial-infarction-and-death
#10
Nima Ghasemzedah, Salim S Hayek, Yi-An Ko, Danny J Eapen, Riyaz S Patel, Pankaj Manocha, Hatem Al Kassem, Mohamed Khayata, Emir Veledar, Dimitrios Kremastinos, Christian W Thorball, Tomasz Pielak, Sergey Sikora, A Maziar Zafari, Stamatios Lerakis, Laurence Sperling, Viola Vaccarino, Stephen E Epstein, Arshed A Quyyumi
BACKGROUND: Inflammation, coagulation, and cell stress contribute to atherosclerosis and its adverse events. A biomarker risk score (BRS) based on the circulating levels of biomarkers C-reactive protein, fibrin degradation products, and heat shock protein-70 representing these 3 pathways was a strong predictor of future outcomes. We investigated whether soluble urokinase plasminogen activator receptor (suPAR), a marker of immune activation, is predictive of outcomes independent of the aforementioned markers and whether its addition to a 3-BRS improves risk reclassification...
March 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28273075/prediction-of-acute-coronary-syndromes-by-urinary-proteome-analysis
#11
Nay M Htun, Dianna J Magliano, Zhen-Yu Zhang, Jasmine Lyons, Thibault Petit, Esther Nkuipou-Kenfack, Adela Ramirez-Torres, Constantin von Zur Muhlen, David Maahs, Joost P Schanstra, Claudia Pontillo, Martin Pejchinovski, Janet K Snell-Bergeon, Christian Delles, Harald Mischak, Jan A Staessen, Jonathan E Shaw, Thomas Koeck, Karlheinz Peter
Identification of individuals who are at risk of suffering from acute coronary syndromes (ACS) may allow to introduce preventative measures. We aimed to identify ACS-related urinary peptides, that combined as a pattern can be used as prognostic biomarker. Proteomic data of 252 individuals enrolled in four prospective studies from Australia, Europe and North America were analyzed. 126 of these had suffered from ACS within a period of up to 5 years post urine sampling (cases). Proteomic analysis of 84 cases and 84 matched controls resulted in the discovery of 75 ACS-related urinary peptides...
2017: PloS One
https://www.readbyqxmd.com/read/28270965/clinical-characterization-of-in-vivo-inflammatory-bowel-disease-with-raman-spectroscopy
#12
Isaac J Pence, Dawn B Beaulieu, Sara N Horst, Xiaohong Bi, Alan J Herline, David A Schwartz, Anita Mahadevan-Jansen
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 1 million Americans and 2 million Europeans, and the incidence is increasing worldwide. While these diseases require unique medical care, the differentiation between UC and CD lacks a gold standard, and therefore relies on long term follow up, success or failure of existing treatment, and recurrence of the disease. Here, we present colonoscopy-coupled fiber optic probe-based Raman spectroscopy as a minimally-invasive diagnostic tool for IBD of the colon (UC and Crohn's colitis)...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28267756/a-stillbirth-calculator-development-and-internal-validation-of-a-clinical-prediction-model-to-quantify-stillbirth-risk
#13
Amanda S Trudell, Methodius G Tuuli, Graham A Colditz, George A Macones, Anthony O Odibo
OBJECTIVE: To generate a clinical prediction tool for stillbirth that combines maternal risk factors to provide an evidence based approach for the identification of women who will benefit most from antenatal testing for stillbirth prevention. DESIGN: Retrospective cohort study. SETTING: Midwestern United States quaternary referral center. POPULATION: Singleton pregnancies undergoing second trimester anatomic survey from 1999-2009...
2017: PloS One
https://www.readbyqxmd.com/read/28264567/microfluidic-impedance-cytometer-with-inertial-focusing-and-liquid-electrodes-for-high-throughput-cell-counting-and-discrimination
#14
Wenlai Tang, Dezhi Tang, Zhonghua Ni, Nan Xiang, Hong Yi
In this paper, we present a novel impedance microcytometer integrated with inertial focusing and liquid electrode techniques for high-throughput cell counting and discrimination. The inertial prefocusing unit orders cells into a determinate train to reduce the possibility of cell adhesions and ensure that only one cell passes through detection region at a time, which improves the accuracy of downstream detection. The liquid electrodes are constructed by inserting Ag/AgCl wires into the electrode chambers filled with flowing highly conductive electrolyte solutions, which have a high detection sensitivity while requiring a simple fabrication process...
March 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28259520/derivation-and-external-validation-of-the-plasmic-score-for-rapid-assessment-of-adults-with-thrombotic-microangiopathies-a-cohort-study
#15
Pavan K Bendapudi, Shelley Hurwitz, Ashley Fry, Marisa B Marques, Stephen W Waldo, Ang Li, Lova Sun, Vivek Upadhyay, Ayad Hamdan, Andrew M Brunner, John M Gansner, Srinivas Viswanathan, Richard M Kaufman, Lynne Uhl, Christopher P Stowell, Walter H Dzik, Robert S Makar
BACKGROUND: Among the syndromes characterised by thrombotic microangiopathy, thrombotic thrombocytopenic purpura is distinguished by a severe deficiency in the ADAMTS13 enzyme. Patients with this disorder need urgent treatment with plasma exchange. Because ADAMTS13 activity testing typically requires prolonged turnaround times and might be unavailable in resource-poor settings, a method to rapidly assess the likelihood of severe ADAMTS13 deficiency is needed. METHODS: All consecutive adult patients presenting to three large academic medical centres in Boston, MA, USA, with thrombotic microangiopathy and a possible diagnosis of thrombotic thrombocytopenic purpura between Jan 8, 2004, and Dec 6, 2015, were included in an ongoing multi-institutional registry (the Harvard TMA Research Collaborative)...
March 1, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28256254/an-enhanced-targeted-identification-strategy-for-the-selective-identification-of-flavonoid-o-glycosides-from-carthamus-tinctorius-by-integrating-offline-two-dimensional-liquid-chromatography-linear-ion-trap-orbitrap-mass-spectrometry-high-resolution-diagnostic
#16
Chang-Liang Yao, Wen-Zhi Yang, Wei Si, Yao Shen, Nai-Xia Zhang, Hua-Li Chen, Hui-Qin Pan, Min Yang, Wan-Ying Wu, De-An Guo
Targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. An enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid O-glycosides (FOGs) from Carthamus tinctorius. It consists of four steps: (i) enhanced separation and detection by offline two-dimensional liquid chromatography/LTQ-Orbitrap MS (offline 2D-LC/LTQ-Orbitrap MS) using collision-induced dissociation (CID) and high-energy C-trap dissociation (HCD); (ii) improved identification of the major aglycones by acid hydrolysis and LC-SPE-NMR; (iii) simplified spectral elucidation by high-resolution diagnostic product ions/neutral loss filtering; and (iv) more convincing structural identification by matching an in-house library...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28255559/urinary-sodium-concentration-is-an-independent-predictor-of-all-cause-and-cardiovascular-mortality-in-a-type-2-diabetes-cohort-population
#17
Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Lise Bankir, Xavier Piguel, Frédéric Fumeron, Vincent Rigalleau, Jean-Michel Halimi, Richard Marechaud, Ronan Roussel, Samy Hadjadj, Surdiagene Study Group
Objective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Methods. Patients were followed for all-cause death and cardiovascular death. Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28253564/incorporating-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-place-of-neutrophil-count-and-platelet-count-improves-prognostic-accuracy-of-the-international-metastatic-renal-cell-carcinoma-database-consortium-model
#18
Pawel Chrom, Rafal Stec, Lubomir Bodnar, Cezary Szczylik
Purpose: The study investigated whether a replacement of neutrophil count and platelet count by neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) within the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model would improve its prognostic accuracy. Materials and Methods: This retrospective analysis included consecutive patients with metastatic renal cell carcinoma treated with first-line tyrosine kinase inhibitors...
March 3, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28253222/phenotyping-of-myocardial-fibrosis-in-hypertensive-patients-with-heart-failure-influence-on-clinical-outcome
#19
Susana Ravassa, Begoña López, Ramón Querejeta, Kattalin Echegaray, Gorka San José, María U Moreno, Francisco J Beaumont, Arantxa González, Javier Díez
OBJECTIVE: Myocardial fibrosis is associated with alterations in the cross-linking and deposition of collagen type I (CCL and CD, respectively). We aimed to evaluate whether the combination of circulating biomarkers of CCL [the carboxy-terminal telopeptide of collagen type I to matrix metalloproteinase-1 ratio (CITP : MMP-1)] and CD [the carboxy-terminal propeptide of procollagen type I (PICP)] identifies myocardial fibrosis phenotypes with distinct clinical outcome in hypertensive patients with heart failure...
April 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28252107/serial-heart-rhythm-complexity-changes-in-patients-with-anterior-wall-st-segment-elevation-myocardial-infarction
#20
Hung-Chih Chiu, Hsi-Pin Ma, Chen Lin, Men-Tzung Lo, Lian-Yu Lin, Cho-Kai Wu, Jiun-Yang Chiang, Jen-Kuang Lee, Chi-Sheng Hung, Tzung-Dau Wang, Li-Yu Daisy Liu, Yi-Lwun Ho, Yen-Hung Lin, Chung-Kang Peng
Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI...
March 2, 2017: Scientific Reports
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