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https://www.readbyqxmd.com/read/29338014/value-of-adding-the-renal-pathological-score-to-the-kidney-failure-risk-equation-in-advanced-diabetic-nephropathy
#1
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Kiyoki Kitagawa, Miho Shimizu, Kengo Furuichi, Takashi Wada
BACKGROUND: There have been a limited number of biopsy-based studies on diabetic nephropathy, and therefore the clinical importance of renal biopsy in patients with diabetes in late-stage chronic kidney disease (CKD) is still debated. We aimed to clarify the renal prognostic value of pathological information to clinical information in patients with diabetes and advanced CKD. METHODS: We retrospectively assessed 493 type 2 diabetics with biopsy-proven diabetic nephropathy in four centers in Japan...
2018: PloS One
https://www.readbyqxmd.com/read/29336097/identification-of-dementia-using-standard-clinical-assessments-by-primary-care-physicians-in-japan
#2
Hiroyuki Noda, Kazumasa Yamagishi, Ai Ikeda, Takashi Asada, Hiroyasu Iso
AIM: The aim of the present study was to develop a way of identifying dementia using clinical assessments made by primary care physicians under the existing medical care system in Japan. METHODS: A total of 623 people aged ≥65 years underwent standard clinical assessments by primary care physicians under the long-term-care insurance program to determine their grade of activities of daily living related to dementia. To examine the validity of the diagnosis, neuropsychiatrists carried out further diagnosis of dementia for all the participants...
January 16, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29321335/serum-hepatocyte-growth-factor-is-probably-associated-with-3-month-prognosis-of-acute-ischemic-stroke
#3
Zhengbao Zhu, Tan Xu, Daoxia Guo, Xinfeng Huangfu, Chongke Zhong, Jingyuan Yang, Aili Wang, Chung-Shiuan Chen, Yanbo Peng, Tian Xu, Jinchao Wang, Yingxian Sun, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND PURPOSE: Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. The goal of this study was to investigate the association between serum HGF and prognosis of ischemic stroke. METHODS: A total of 3027 acute ischemic stroke patients were included in this post hoc analysis of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke)...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29315062/invasive-breast-cancer-prognostic-value-of-peritumoral-edema-identified-at-preoperative-mr-imaging
#4
Hyejin Cheon, Hye Jung Kim, Tae Hun Kim, Hun-Kyu Ryeom, Jongmin Lee, Gab Chul Kim, Jin-Sung Yuk, Won Hwa Kim
Purpose To determine the prognostic value of peritumoral edema identified at preoperative breast magnetic resonance (MR) imaging for disease recurrence in patients with invasive breast cancer. Materials and Methods Between January 2011 and December 2012, 353 women (median age, 49 years; range, 27-77 years) with invasive breast cancer who had undergone preoperative MR imaging and mastectomy or breast-conserving surgery were identified. Two radiologists independently reviewed peritumoral edema on the basis of the degree of the signal intensity surrounding the tumor on T2-weighted images...
January 9, 2018: Radiology
https://www.readbyqxmd.com/read/29311270/revised-framingham-stroke-risk-score-nontraditional-risk-markers-and-incident-stroke-in-a-multiethnic-cohort
#5
Peter Flueckiger, Will Longstreth, David Herrington, Joseph Yeboah
BACKGROUND AND PURPOSE: Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by nontraditional risk markers. METHODS: Six thousand seven hundred twelve of 6814 participants of the MESA (Multi-Ethnic Study of Atherosclerosis) were included...
January 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29306485/comparison-of-carbohydrate-antigen-125-and-n-terminal-pro-brain-natriuretic-peptide-for-risk-prediction-after-transcatheter-aortic-valve-implantation
#6
Tobias Rheude, Costanza Pellegrini, Hans Schmid, Teresa Trenkwalder, N Patrick Mayr, Michael Joner, Albert M Kasel, Stefan Holdenrieder, Julio Nunez, Juan Sanchis, Vicent Bodi, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic peptide (NTproBNP) have been associated with adverse outcome after transcatheter aortic valve implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after TAVI. The study includes 363 patients. The primary end point was all-cause death or readmission for worsening congestive heart failure within 1 year after TAVI, and this end point occurred in 16% of the population. The optimal cutoff to predict the primary end point was 18...
November 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29302179/where-public-health-meets-human-rights-integrating-human-rights-into-the-validation-of-the-elimination-of-mother-to-child-transmission-of-hiv-and-syphilis
#7
Eszter Kismödi, Karusa Kiragu, Olga Sawicki, Sally Smith, Sophie Brion, Aditi Sharma, Lilian Mworeko, Alexandrina Iovita
In 2014, the World Health Organization (WHO) initiated a process for validation of the elimination of mother-to-child transmission (EMTCT) of HIV and syphilis by countries. For the first time in such a process for the validation of disease elimination, WHO introduced norms and approaches that are grounded in human rights, gender equality, and community engagement. This human rights-based validation process can serve as a key opportunity to enhance accountability for human rights protection by evaluating EMTCT programs against human rights norms and standards, including in relation to gender equality and by ensuring the provision of discrimination-free quality services...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29288657/a-pragmatic-preoperative-prediction-score-for-non-home-discharge-after-cardiac-surgery
#8
Jenna Stuebe, Jessica Rydingsward, Heather Lander, Jillian Ng, Xinling Xu, Tsuyoshi Kaneko, Prem Shekar, Jochen D Muehlschlegel, Simon C Body
BACKGROUND: Targeted rehabilitation of patients at risk for non-home discharge (NHD) following surgery is an appealing area for quality improvement. We sought to identify the primary predictors of NHD following cardiac surgery in order to generate a robust preoperative prediction tool for those at greatest risk. METHODS: The medical records of 5,253 patients undergoing cardiac surgery between 1/1/2012 - 3/31/2016 were reviewed. Two models of NHD were created; a preoperative model using only preoperative predictors and a postoperative model using the same preoperative predictors, and including postoperative adverse outcomes and duration of hospital stay...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29287851/hearing-improvement-with-softband-and-implanted-bone-anchored-hearing-devices-and-modified-implantation-surgery-in-patients-with-bilateral-microtia-atresia
#9
Yibei Wang, Xinmiao Fan, Pu Wang, Yue Fan, Xiaowei Chen
OBJECTIVE: To evaluate auditory development and hearing improvement in patients with bilateral microtia-atresia using softband and implanted bone-anchored hearing devices and to modify the implantation surgery. METHODS: The subjects were divided into two groups: the softband group (40 infants, 3 months to 2 years old, Ponto softband) and the implanted group (6 patients, 6-28 years old, Ponto). The Infant-Toddler Meaning Auditory Integration Scale was used conducted to evaluate auditory development at baseline and after 3, 6, 12, and 24 months, and visual reinforcement audiometry was used to assess the auditory threshold in the softband group...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29280189/adiponectin-concentration-data-improve-the-estimation-of-atherosclerotic-risk-in-normal-and-in-overweight-subjects
#10
Adriana Bertolami, José C de Lima-Júnior, Riobaldo M Cintra, Luiz S Carvalho, Carolina de C Gonzaga, Martha L Sulzbach, Ana C G P Petisco, José E M Barbosa, André A Faludi, Jorge Plutzky, Marcelo C Bertolami, Andrei C Sposito
BACKGROUND: The combinations of adipokines and body mass parameters to estimate carotid atherosclerotic disease have not been completely delineated. OBJECTIVE: To test the combinations of well-established, easily accessible body mass indices and circulating biomarkers to identify increased carotid intima-media thickness (cIMT) in a primary prevention setting. DESIGN AND PATIENTS: In a cross-sectional analysis of 339 asymptomatic individuals with no history of cardiovascular events, inflammatory and insulin sensitivity biomarkers as well as adipokine levels were measured and combined with body mass parameters to evaluate the best marker for increased cIMT...
December 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29277058/the-ifst-an-instrumented-version-of-the-fukuda-stepping-test-for-balance-assessment
#11
Valeria Belluscio, Elena Bergamini, Marco Iosa, Marco Tramontano, Giovanni Morone, Giuseppe Vannozzi
The maintenance of the upright posture during dynamic balance requires the integration of sensory inputs regulated by the brain. After a neurological event, the assessment of balance control impairments is crucial for supporting health professionals in the design of personalized rehabilitation protocols. A commonly used test to assess balance ability is the Fukuda Stepping Test (FST). However, the clinical parameters traditionally considered are not fully representative of the patient's motor ability. The purpose of this study was to devise an instrumented version of the FST (iFST) that embodies inertial sensors and allows to obtain individual motor strategy information...
December 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29259038/one-hour-glucose-value-as-a-long-term-predictor-of-cardiovascular-morbidity-and-mortality-the-malm%C3%A3-preventive-project
#12
Mette Lundgren Nielsen, Manan Pareek, Margrét Leósdóttir, Karl-Fredrik Eriksson, Peter Nilsson, Michael Hecht Olsen
OBJECTIVE: To examine the predictive capability of a 1-hour versus 2-hour postload glucose value for cardiovascular morbidity and mortality. DESIGN: Prospective, population-based cohort study (Malmö Preventive Project) with subject inclusion 1974-1992. METHODS: 4934 men without known diabetes and cardiovascular disease, who had blood glucose (BG) measured at 0, 20, 40, 60, 90 and 120 min during an OGTT (30g glucose per m2 body surface area), were followed for 27 years...
December 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29243824/apoplastp-prediction-of-effectors-and-plant-proteins-in-the-apoplast-using-machine-learning
#13
Jana Sperschneider, Peter N Dodds, Karam B Singh, Jennifer M Taylor
The plant apoplast is integral to intercellular signalling, transport and plant-pathogen interactions. Plant pathogens deliver effectors both into the apoplast and inside host cells, but no computational method currently exists to discriminate between these localizations. We present ApoplastP, the first method for predicting whether an effector or plant protein localizes to the apoplast. ApoplastP uncovers features of apoplastic localization common to both effectors and plant proteins, namely depletion in glutamic acid, acidic amino acids and charged amino acids and enrichment in small amino acids...
December 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#14
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29239125/autofluorescence-and-white-light-imaging-guided-endoscopic-raman-and-diffuse-reflectance-spectroscopy-for-in-vivo-nasopharyngeal-cancer-detection
#15
Duo Lin, Sufang Qiu, Wei Huang, Jianji Pan, Zhihong Xu, Rong Chen, Shangyuan Feng, Guannan Chen, Yongzeng Li, Michael Short, Jianhua Zhao, Yasser Fawzy, Haishan Zeng
Nasopharyngeal cancer (NPC) is an endemic with high incidence in Southern China and Southeast Asia countries. Screening for NPC under conventional white light imaging (WLI) nasopharyngoscope examination remains a great clinical challenge due to its poor sensitivity. Here, we developed an integrated four-modality endoscopy system combining WLI, autofluorescence imaging (AFI), diffuse reflectance spectroscopy (DRS), and Raman spectroscopy (RS) technologies for in vivo endoscopic cancer detection for the first time...
December 14, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29237554/feature-based-attention-potentiates-recovery-of-fine-direction-discrimination-in-cortically-blind-patients
#16
Matthew R Cavanaugh, Antoine Barbot, Marisa Carrasco, Krystel R Huxlin
Training chronic, cortically-blind (CB) patients on a coarse [left-right] direction discrimination and integration (CDDI) task recovers performance on this task at trained, blind field locations. However, fine direction difference (FDD) thresholds remain elevated at these locations, limiting the usefulness of recovered vision in daily life. Here, we asked if this FDD impairment can be overcome by training CB subjects with endogenous, feature-based attention (FBA) cues. Ten CB subjects were recruited and trained on CDDI and FDD with an FBA cue or FDD with a neutral cue...
December 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29237416/a-network-based-predictive-gene-expression-signature-for-adjuvant-chemotherapy-benefit-in-stage-ii-colorectal-cancer
#17
Bangrong Cao, Liping Luo, Lin Feng, Shiqi Ma, Tingqing Chen, Yuan Ren, Xiao Zha, Shujun Cheng, Kaitai Zhang, Changmin Chen
BACKGROUND: The clinical benefit of adjuvant chemotherapy for stage II colorectal cancer (CRC) is controversial. This study aimed to explore novel gene signature to predict outcome benefit of postoperative 5-Fu-based therapy in stage II CRC. METHODS: Gene-expression profiles of stage II CRCs from two datasets with 5-Fu-based adjuvant chemotherapy (training dataset, n = 212; validation dataset, n = 85) were analyzed to identify the indicator. A systemic approach by integrating gene-expression and protein-protein interaction (PPI) network was implemented to develop the predictive signature...
December 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29229941/urinary-endotrophin-predicts-disease-progression-in-patients-with-chronic-kidney-disease
#18
Daniel Guldager Kring Rasmussen, Anthony Fenton, Mark Jesky, Charles Ferro, Peter Boor, Martin Tepel, Morten Asser Karsdal, Federica Genovese, Paul Cockwell
Renal fibrosis is the central pathogenic process in progression of chronic kidney disease (CKD). Collagen type VI (COL VI) is upregulated in renal fibrosis. Endotrophin is released from COL VI and promotes pleiotropic pro-fibrotic effects. Kidney disease severity varies considerably and accurate information regarding CKD progression may improve clinical decisions. We tested the hypothesis that urinary endotrophin derived during COL VI deposition in fibrotic human kidneys is a marker for progression of CKD in the Renal Impairment in Secondary Care (RIISC) cohort, a prospective observational study of 499 CKD patients...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229724/serum-galectin-3-and-poor-outcomes-among-patients-with-acute-ischemic-stroke
#19
Aili Wang, Chongke Zhong, Zhengbao Zhu, Tian Xu, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Jianhui Zhang, Xiaodong Yuan, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND PURPOSE: Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke. METHODS: Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29225686/prognostic-value-of-a-patient-reported-functional-score-versus-physician-reported-karnofsky-performance-status-score-in-brain-metastases
#20
Jai Prakash Agarwal, Santam Chakraborty, Sarbani Ghosh Laskar, Naveen Mummudi, Vijay M Patil, Kumar Prabhash, Vanita Noronha, Nilendu Purandare, Amit Joshi, Sandeep Tandon, Jitendra Arora, Rupali Badhe
Introduction: Our aim was to investigate the added prognostic value of a patient-reported functional outcome score over Karnofsky Performance Status (KPS) in patients with non-small-cell lung cancers (NSCLC) with brain metastases. Materials and methods: The baseline data are from a prospective cohort study involving 140 consecutive patients presenting at our institute. A patient reported performance status (PRPS) was obtained by summing the physical- and role-functioning scale scores of the EORTC QLQ C30 questionnaire...
2017: Ecancermedicalscience
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