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https://www.readbyqxmd.com/read/29055288/osteoinductive-effects-of-cyplexinol-in-the-management-of-osteoporosis-a-case-series
#1
Daniel Tripodi
Aims • A case study was conducted on a subject with a history of documented bone loss and the observed outcome of bone mineral density (BMD) changes when utilizing supplementation with Cyplexinol, a natural bone morphogenetic protein complex. Method and Results • A case of osteoporosis was reviewed with pertinent medical history and dual energy X-ray absorptiometry history described both pre- and postsupplementation. Results demonstrated a significant change in bone density parameter for the individual when the bone support supplement, Cyplexinol, was used...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055281/application-of-wavelet-and-fuorier-transforms-as-powerful-alternatives-for-derivative-spectrophotometry-in-analysis-of-binary-mixtures-a-comparative-study
#2
Said A Hassan, Sherif A Abdel-Gawad
Two signal processing methods, namely, Continuous Wavelet Transform (CWT) and the second was Discrete Fourier Transform (DFT) were introduced as alternatives to the classical Derivative Spectrophotometry (DS) in analysis of binary mixtures. To show the advantages of these methods, a comparative study was performed on a binary mixture of Naltrexone (NTX) and Bupropion (BUP). The methods were compared by analyzing laboratory prepared mixtures of the two drugs. By comparing performance of the three methods, it was proved that CWT and DFT methods are more efficient and advantageous in analysis of mixtures with overlapped spectra than DS...
August 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055280/optical-limiting-properties-of-3-5-dipyrenylvinylenebodipy-dyes-at-532nm
#3
Gugu Kubheka, Kayode Sanusi, John Mack, Tebello Nyokong
The optical limiting (OL) properties of 3,5-dipyrenylvinyleneBODIPY dyes that contain both electron withdrawing and donating moieties have been investigated by using the z-scan technique at 532nm in the nanosecond pulse range. The extension of the π-conjugation at the 3,5-positions with pyrenylvinylene groups results in a ca. 200nm red shift of the main BODIPY spectral band to ca. 700nm, so there is relatively weak absorbance at 532nm under ambient light conditions. Reverse saturable absorbance (RSA) profiles are observed in response to incident pulsed laser light that is consistent with a two photon absorption-assisted excited state absorption (ESA) mechanism in CH2Cl2 solution and when the dyes are embedded in poly(bisphenol carbonate A) (PBC) polymer thin films...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055278/enhanced-sensitivity-to-detection-nanomolar-level-of-cu-2-compared-to-spectrophotometry-method-by-functionalized-gold-nanoparticles-design-of-sensor-assisted-by-exploiting-first-order-data-with-chemometrics
#4
Zolaikha Rasouli, Raouf Ghavami
A simple, sensitive and efficient colorimetric assay platform for the determination of Cu(2+) was proposed with the aim of developing sensitive detection based on the aggregation of AuNPs in presence of a histamine H2-receptor antagonist (famotidine, FAM) as recognition site. This study is the first to demonstrate that the molar extinction coefficients of the complexes formed by FAM and Cu(2+) are very low (by analyzing the chemometrics methods on the first order data arising from different metal to ligand ratio method), leading to the undesirable sensitivity of FAM-based assays...
October 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#5
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055235/a-traditional-american-indian-death-ritual-developing-nursing-knowledge-through-aesthetic-exposure
#6
Barbara K Charbonneau-Dahlen
The theoretical and practical application of Boykin and Schoenhofer's Nursing as Caring: A Model for Transforming Practice (2001) provided a framework for the exploration of an aesthetic project of quilting, which was undertaken in order to explain the death journey for a cherished mentor of American Indian nursing students. In particular, the nursing situation was used to guide the making of the quilt sampler. Aesthetics nested into the teaching-learning process became another way to help students solidify their professional self-identity as caring persons...
October 12, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29055230/development-and-evaluation-of-novel-biodegradable-chitosan-based-metformin-intrapocket-dental-film-for-the-management-of-periodontitis-and-alveolar-bone-loss-in-a-rat-model
#7
Deepak Kumar Khajuria, Omprakash Nandikamba Patil, David Karasik, Rema Razdan
OBJECTIVE: The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis. DESIGN: CMIDF inserts were fabricated by the solvent casting technique. The fabricated inserts were evaluated for physical characteristics such as folding endurance, surface pH, mucoadhesive strength, metformin content uniformity, and release. X-ray diffraction analysis indicates no crystallinity of metformin in presence of chitosan which confirmed successful entrapment of metformin into the CMIDF...
October 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29055227/generation-and-characterization-of-human-ipsc-lines-sani001-a-and-sani002-a-from-mobilized-peripheral-blood-derived-megakaryoblasts
#8
Marten Hansen, Eszter Varga, Tatjana Wüst, Clemens Mellink, Anne-Marie van der Kevie-Kersemaekers, Marieke von Lindern, Emile van den Akker
Mobilized peripheral blood (MPB) CD34+ cells were differentiated to CD34(+)/CD41(+) megakaryoblasts. Cells were sorted to obtain a pure megakaryoblast population which was reprogrammed with a hOKSM self-silencing polycistronic lentiviral vector. Resulting iPSC showed normal karyotype and expression of pluripotency associated markers and in vitro spontaneous differentiation towards the 3 germ layers confirmed pluripotency of iPSC lines. Besides normal iPSC applications, these lines can be used as a control line for other megakaryoid origin iPSC and could be applied for epigenetic based research...
October 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29055205/development-of-qsar-models-for-predicting-the-binding-affinity-of-endocrine-disrupting-chemicals-to-eight-fish-estrogen-receptor
#9
Junyi He, Tao Peng, Xianhai Yang, Huihui Liu
Endocrine disrupting effect has become a central point of concern, and various biological mechanisms involve in the disruption of endocrine system. Recently, we have explored the mechanism of disrupting hormonal transport protein, through the binding affinity of sex hormone-binding globulin in different fish species. This study, serving as a companion article, focused on the mechanism of activating/inhibiting hormone receptor, by investigating the binding interaction of chemicals with the estrogen receptor (ER) of different fish species...
October 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29055202/tio2-nanoparticles-in-seawater-aggregation-and-interactions-with-the-green-alga-dunaliella-tertiolecta
#10
Elisabetta Morelli, Edi Gabellieri, Alessandra Bonomini, Danika Tognotti, Giacomo Grassi, Ilaria Corsi
Titanium dioxide nanoparticles (TiO2 NPs) have been widely employed in industrial applications, thus rising concern about their impact in the aquatic environment. In this study we investigated the chemical behaviour of TiO2 NPs in the culture medium and its effect on the green alga Dunaliella tertiolecta, in terms of growth inhibition, oxidative stress, ROS (Reactive Oxygen Species) accumulation and chlorophyll content. In addition, the influence of exopolymeric substances (EPS) excreted by the microalgae on the stability of NPs has been evaluated...
October 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29055193/specific-bioanalytical-optical-and-photoelectrochemical-assays-for-detection-of-methanol-in-alcoholic-beverages
#11
Javier Barroso, Beatriz Díez-Buitrago, Laura Saa, Marco Möller, Nerea Briz, Valeri Pavlov
Methanol is a poison which is frequently discovered in alcoholic beverages. Innovative methods to detect methanol in alcoholic beverages are being constantly developed. We report for the first time a new strategy for the detection of methanol using fluorescence spectroscopy and photoelectrochemical (PEC) analysis. The analytical system is based on the oxidation of cysteine (CSH) with hydrogen peroxide (H2O2) enzymatically generated by alcohol oxidase (AOx). H2O2 oxidizes capping agent CSH, modulating the growth of CSH-stabilized cadmium sulphide quantum dots (CdS QDs)...
October 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055192/electrochemical-immunosensor-with-nanocellulose-au-composite-assisted-multiple-signal-amplification-for-detection-of-avian-leukosis-virus-subgroup-j
#12
Chao Liu, Jing Dong, Geoffrey I N Waterhouse, Ziqiang Cheng, Shiyun Ai
A sensitive sandwich-type electrochemical immunosensor was developed for the detection of avian leukosis virus subgroup J (ALV-J), which benefitted from multiple signal amplification involving graphene-perylene-3,4,9,10-tetracarboxylic acid nanocomposites (GR-PTCA), nanocellulose-Au NP composites (NC-Au) and the alkaline phosphatase (ALP) catalytic reaction. GR-PTCA nanocomposites on glassy carbon electrodes served as the immunosensor platform. Due to their excellent electrical conductivity and abundant polycarboxylic sites, the GR-PTCA nanocomposites allowed fast electron transfer and good immobilization of primary antibodies, thereby affording a strong immunosensor signal in the presence of ALV-J...
October 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055163/microbial-sensor-for-drug-susceptibility-testing-of-mycobacterium-tuberculosis
#13
Zhi-Tao Zhang, Dian-Bing Wang, Chuan-You Li, Jiao-Yu Deng, Ji-Bin Zhang, Li-Jun Bi, Xian-En Zhang
AIMS: Drug susceptibility testing (DST) of clinical isolates of Mycobacterium tuberculosis (M. tuberculosis) is critical in treating tuberculosis. We demonstrate the possibility of using a microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST. METHODS AND RESULTS: The sensor is made of an oxygen electrode with M. tuberculosis cells attached to its surface. This sensor monitors the residual oxygen consumption of M. tuberculosis cells after treatment with anti-TB drugs with glycerine as a carbon source...
October 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29055158/a-phase-2a-randomized-controlled-study-to-evaluate-the-pharmacokinetic-safety-tolerability-and-clinical-effect-of-topically-applied-umeclidinium-in-subjects-with-primary-axillary-hyperhidrosis
#14
A Nasir, R Bissonnette, C Maari, J DuBois, T Pene Dumitrescu, J Haddad, Y Yamaguchi, M Dalessandro
BACKGROUND: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long acting muscarinic antagonist (LAMA) developed as a dermal formulation. OBJECTIVES: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety, and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Clinical effect was a secondary objective, measured by gravimetry and the hyperhidrosis disease severity scale (HDSS)...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055137/reply-to-topical-ionic-contra-viral-therapy-comprised-of-digoxin-and-furosemide-as-a-potential-novel-treatment-approach-for-common-warts
#15
Ayman Abdelmaksoud
I read with great interest a preliminary study on new treatment for common warts conducted by Kolk et al.(1) The authors studied, for the first time, the clinical response of common warts to topical application of a fixed dose of 980 mg topical gel containing 0.125% (w/w) digoxin and 0.125% (w/w) furosemide for 7 consecutive days on the patients' lower back. Basically, topical therapy for a common dermatosis is generally welcomed particularly if showed a higher degree of safety profile and less potential off-target adverse effects...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055106/streptavidin-coated-surfaces-suppress-bacterial-colonisation-by-inhibiting-non-specific-protein-adsorption
#16
Volker Ettelt, Katharina Ekat, Peer W Kämmerer, Bernd Kreikemeyer, Matthias Epple, Michael Veith
Streptavidin is a 58 kDa tetrameric protein with the highest known affinity to biotin with a wide range of applications in bionanotechnology and molecular biology. Dissolved streptavidin is stable at a broad range of temperature, pH, proteolytic enzymes and exhibits low non-specific binding. In this study, a streptavidin monolayer was assembled directly on a biotinylated TiO2 -surface to investigate its stability against proteolytic digestion and its suppression of initial bacterial adsorption of Escherichia coli, Bacillus subtilis, and Streptococcus intermedius...
October 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29055100/optical-emission-of-223-radium-in-vitro-and-in-vivo-preclinical-applications
#17
Federico Boschi, Francesco De Sanctis, Antonello E Spinelli
(223) Radium ((223) Ra) is widely used in Nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice (223) Ra cannot be imaged directly, however gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work we show that (223) Ra and its short-lived daughter nuclides can be detected with optical imaging techniques. The light emission of (223) Ra was investigated in vitro using different setups in order to clarify the mechanism of light production...
October 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29055096/an-improved-method-for-bivariate-meta-analysis-when-within-study-correlations-are-unknown
#18
Chuan Hong, Richard D Riley, Yong Chen
Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the dependence between multiple estimates from the same study. However, standard inference procedures for multivariate meta-analysis require the knowledge of within-study correlations, which are usually unavailable. This limits standard inference approaches in practice...
October 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29055073/ppnac1-a-main-regulator-of-phenylalanine-biosynthesis-and-utilization-in-maritime-pine
#19
Mª Belén Pascual, María-Teresa Llebrés, Blanca Craven-Bartle, Rafael A Cañas, Francisco M Cánovas, Concepción Ávila
The transcriptional regulation of phenylalanine metabolism is particularly important in conifers, long-lived species that use large amounts of carbon in wood. Here, we show that the Pinus pinaster transcription factor, PpNAC1, is a main regulator of phenylalanine biosynthesis and utilization. A phylogenetic analysis classified PpNAC1 in the NST proteins group, and was selected for functional characterization. PpNAC1 is predominantly expressed in the secondary xylem and compression wood of adult trees. Silencing of PpNAC1 in P...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29055065/simultaneous-determination-of-usnic-diffractaic-evernic-and-barbatic-acids-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-quadrupole-exactive-orbitrap-mass-spectrometry-and-its-application-to-pharmacokinetic-studies
#20
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang
Usnea longissima Ach. (Usnea) has been used in pharmaceuticals, food, cosmetics. Evernic acid (EA), barbatic acid (BA), diffractaic acid (DA), and usnic acid (UA) are the most typical ingredients in U. longissima and exert a wide variety of biological functions. The study aim to develop a sensitive method for simultaneous analysis of EA, BA, DA, and UA in rat plasma and applied to pharmacokinetic studies after consumption of UA and ethanol extract from U. longissima (UE). The samples were separated on BEH C18 column by gradient elution with 0...
October 21, 2017: Biomedical Chromatography: BMC
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