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https://www.readbyqxmd.com/read/28215054/semiparametric-modeling-and-analysis-of-longitudinal-method-comparison-data
#1
Lasitha N Rathnayake, Pankaj K Choudhary
Studies comparing two or more methods of measuring a continuous variable are routinely conducted in biomedical disciplines with the primary goal of measuring agreement between the methods. Often, the data are collected by following a cohort of subjects over a period of time. This gives rise to longitudinal method comparison data where there is one observation trajectory for each method on every subject. It is not required that observations from all methods be available at each observation time. The multiple trajectories on the same subjects are dependent...
February 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28215053/-the-first-intervention-is-leaving-home-reasons-for-electing-an-out-of-hospital-birth-among-minnesotan-mothers
#2
Helen Hazen
The Twin Cities, Minnesota has seen a recent increase in the number of mothers seeking an out-of-hospital birth. This research uses in-depth interviews with 24 mothers who intended an out-of-hospital birth in the previous two years, exploring their reasons for pursuing an alternative approach to birth. For many women an out-of-hospital birth fits within a philosophy that rejects the pathologizing of birth. Escaping rigid hospital protocols is seen as critical to avoiding what many mothers described as unnecessary interventions...
February 18, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/28215045/a-generalized-partially-linear-mean-covariance-regression-model-for-longitudinal-proportional-data-with-applications-to-the-analysis-of-quality-of-life-data-from-cancer-clinical-trials
#3
Xueying Zheng, Guoyou Qin, Dongsheng Tu
Motivated by the analysis of quality of life data from a clinical trial on early breast cancer, we propose in this paper a generalized partially linear mean-covariance regression model for longitudinal proportional data, which are bounded in a closed interval. Cholesky decomposition of the covariance matrix for within-subject responses and generalized estimation equations are used to estimate unknown parameters and the nonlinear function in the model. Simulation studies are performed to evaluate the performance of the proposed estimation procedures...
February 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28215038/variable-selection-and-prediction-in-biased-samples-with-censored-outcomes
#4
Ying Wu, Richard J Cook
With the increasing availability of large prospective disease registries, scientists studying the course of chronic conditions often have access to multiple data sources, with each source generated based on its own entry conditions. The different entry conditions of the various registries may be explicitly based on the response process of interest, in which case the statistical analysis must recognize the unique truncation schemes. Moreover, intermittent assessment of individuals in the registries can lead to interval-censored times of interest...
February 18, 2017: Lifetime Data Analysis
https://www.readbyqxmd.com/read/28215010/key-actions-towards-the-sustainable-management-of-european-geese
#5
David A Stroud, Jesper Madsen, Anthony D Fox
Increasing abundance of geese in North America and Europe constitutes a major conservation success, but has caused increasing conflicts with economic, health and safety interests, as well as ecosystem impacts. Potential conflict resolution through a single, 'one size fits all' policy is hindered by differences in species' ecology, behaviour, abundance and population status, and in contrasting political and socio-economic environments across the flyways. Effective goose management requires coordinated application of a suite of tools from the local level to strategic flyway management actions...
March 2017: Ambio
https://www.readbyqxmd.com/read/28215003/improved-electromagnetic-tracking-for-catheter-path-reconstruction-with-application-in-high-dose-rate-brachytherapy
#6
Elodie Lugez, Hossein Sadjadi, Chandra P Joshi, Selim G Akl, Gabor Fichtinger
PURPOSE: Electromagnetic (EM) catheter tracking has recently been introduced in order to enable prompt and uncomplicated reconstruction of catheter paths in various clinical interventions. However, EM tracking is prone to measurement errors which can compromise the outcome of the procedure. Minimizing catheter tracking errors is therefore paramount to improve the path reconstruction accuracy. METHODS: An extended Kalman filter (EKF) was employed to combine the nonlinear kinematic model of an EM sensor inside the catheter, with both its position and orientation measurements...
February 18, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28214995/development-and-characterization-of-monoclonal-antibody-against-human-il-37b
#7
Yu-Chi Gao, Yan Jia, De-Qian Xiao, Xin Wang, You-Chao Dai, Shi-Yan Yu, Chen Chen, Ze-Gang Zhuang, Xiao-Xia Fu, Jun-Ai Zhang, Bi-Ying Zheng, Zhi-Hong Chen, Ji-Xin Zhong, Zhang-Quan Chen, Jun-Fa Xu
IL-37 has been described as a natural inhibitor of immune responses. Monoclonal antibody (mAb) against human IL-37b with high affinity and specificity can serve as a molecular probe to detect IL-37 and study IL-37 functions, mechanisms and related signal pathways in inflammatory diseases. However, there are very few such mAbs against human IL-37 commercially available so far. In the current study, monoclonal antibodies against human IL-37b were developed by fusing splenocytes from immunized mouse with SP2/0 myeloma cells and polyethylene glycol...
February 18, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28214993/scaleus-semantic-web-services-integration-for-biomedical-applications
#8
Pedro Sernadela, Lorena González-Castro, José Luís Oliveira
In recent years, we have witnessed an explosion of biological data resulting largely from the demands of life science research. The vast majority of these data are freely available via diverse bioinformatics platforms, including relational databases and conventional keyword search applications. This type of approach has achieved great results in the last few years, but proved to be unfeasible when information needs to be combined or shared among different and scattered sources. During recent years, many of these data distribution challenges have been solved with the adoption of semantic web...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28214992/data-mining-in-hiv-aids-surveillance-system-application-to-portuguese-data
#9
Alexandra Oliveira, Brígida Mónica Faria, A Rita Gaio, Luís Paulo Reis
The Human Immunodeficiency Virus (HIV) is an infectious agent that attacks the immune system cells. Without a strong immune system, the body becomes very susceptible to serious life threatening opportunistic diseases. In spite of the great progresses on medication and prevention over the last years, HIV infection continues to be a major global public health issue, having claimed more than 36 million lives over the last 35 years since the recognition of the disease. Monitoring, through registries, of HIV-AIDS cases is vital to assess general health care needs and to support long-term health-policy control planning...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28214991/efficiency-analysis-of-an-interoperable-healthcare-operations-platform
#10
Thomas F Osborne, Reese H Clark, Jason Blackowiak, Patrick J Williamson, Shannon M Werb, Benjamin W Strong
(1) Develop an enterprise platform to unify isolated information, software applications and team members. (2) Assess the efficiency of one benefit of the platform through comparative testing of employee document retrieval times. (3) Evaluate the level of satisfaction among our target audience. We developed an infrastructure to integrate information throughout our practice and make it available on a unified, secure, and remotely accessible platform. We solicited our practice for volunteers to test the new system...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28214986/astrocyte-sodium-signalling-and-panglial-spread-of-sodium-signals-in-brain-white-matter
#11
Behrouz Moshrefi-Ravasdjani, Evelyn L Hammel, Karl W Kafitz, Christine R Rose
In brain grey matter, excitatory synaptic transmission activates glutamate uptake into astrocytes, inducing sodium signals which propagate into neighboring astrocytes through gap junctions. These sodium signals have been suggested to serve an important role in neuro-metabolic coupling. So far, it is unknown if astrocytes in white matter-that is in brain regions devoid of synapses-are also able to undergo such intra- and intercellular sodium signalling. In the present study, we have addressed this question by performing quantitative sodium imaging in acute tissue slices of mouse corpus callosum...
February 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28214935/promotive-role-of-5-aminolevulinic-acid-on-chromium-induced-morphological-photosynthetic-and-oxidative-changes-in-cauliflower-brassica-oleracea-botrytis-l
#12
Rehan Ahmad, Shafaqat Ali, Fakhir Hannan, Muhammad Rizwan, Muhammad Iqbal, Zaidul Hassan, Nudrat Aisha Akram, Saliha Maqbool, Farhat Abbas
Chromium (Cr) is among the most toxic pollutants in the environment that adversely affect the living organisms and physiological processes in different plants. The present study investigated the effect of 15 mg L(-1) of 5-aminolevulinic acid (ALA) on morpho-physiological attributes of cauliflower (Brassica oleracea botrytis L.) under different Cr concentrations (0, 10, 100, and 200 μM) in the growth medium. The results showed that Cr stress decreased the growth, biomass, photosynthetic, and gas exchange parameters...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214878/mirna-26a-contributes-to-the-acquisition-of-malignant-behaviors-of-doctaxel-resistant-lung-adenocarcinoma-cells-through-targeting-ezh2
#13
Jing Chen, Yuejuan Xu, Leilei Tao, Yan Pan, Kai Zhang, Rui Wang, Long-Bang Chen, Xiaoyuan Chu
BACKGROUND/AIMS: Accumulating evidence revealed that microRNAs (miRNAs) have been demonstrated as critical molecules in tumor development and progression. MiR-26a, located in a fragile chromosomal region associated with various human cancer, has been reported to be involved in regulating various cellular process, such as proliferation, apoptosis and invasion through targeting multiple oncogene. Docetaxel-mediated chemotherapy has been applied in improving the survival and prognosis of patients with advanced lung adenocarcinoma (LAD)...
February 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214848/human-birth-weight-and-reproductive-immunology-testing-for-interactions-between-maternal-and-offspring-kir-and-hla-c-genes
#14
Michelle M Clark, Olympe Chazara, Eric M Sobel, Håkon K Gjessing, Per Magnus, Ashley Moffett, Janet S Sinsheimer
BACKGROUND/AIMS: Maternal and offspring cell contact at the site of placentation presents a plausible setting for maternal-fetal genotype (MFG) interactions affecting fetal growth. We test hypotheses regarding killer cell immunoglobulin-like receptor (KIR) and HLA-C MFG effects on human birth weight by extending the quantitative MFG (QMFG) test. METHODS: Until recently, association testing for MFG interactions had limited applications. To improve the ability to test for these interactions, we developed the extended QMFG test, a linear mixed-effect model that can use multi-locus genotype data from families...
February 18, 2017: Human Heredity
https://www.readbyqxmd.com/read/28214784/cross-cultural-relevance-of-the-interpersonal-theory-of-suicide-across-korean-and-u-s-undergraduate-students
#15
Sooyeon Suh, Chad K Ebesutani, Christopher R Hagan, Megan L Rogers, Melanie A Hom, Fallon B Ringer, Rebecca A Bernert, Soohyun Kim, Thomas E Joiner
: This study investigated the cross-cultural relevance and validity of the Interpersonal Theory of Suicide (ITS) utilizing young adult samples from South Korea (n =554) and the United States (U.S.; n =390). To examine the ITS, all participants completed self-report questionnaires measuring Thwarted Belongingness, Perceived Burdensomeness, and Capability for Suicide. We examined whether each construct significantly predicted the severity of suicidal risk in both samples. We also determined whether the strength of the effects of Thwarted Belongingness and Perceived Burdensomeness on suicidal ideation differed between the two samples due to the greater degree of importance placed on interpersonal relationships in collectivistic cultures such as South Korea...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214775/role-of-c-di-gmp-in-anammox-aggregation-and-systematic-analysis-of-its-turnover-protein-in-candidatus-jettenia-caeni
#16
Yongzhao Guo, Sitong Liu, Xi Tang, Fenglin Yang
The anaerobic ammonium oxidation (anammox) process has been recognized as a promising sewage treatment approach. Considering the susceptibility, it is meaningful to study the behaviors of anammox bacteria under the unfavorable conditions. Here, we found that anammox bacteria more probably tended to aggregation by the regulation of c-di-GMP against the unfavorable environmental stresses (low temperature, aerobic condition and low pH). Further using multiple protein sequence alignment, we systematically examined the functionality of thirteen genes encoding putative c-di-GMP metabolic enzymes in anammox organism Candidatus Jettenia caeni, revealing most of the predicted enzymes were predicted to be active...
February 12, 2017: Water Research
https://www.readbyqxmd.com/read/28214756/multifarious-applications-of-atomic-force-microscopy-in-forensic-science-investigations
#17
REVIEW
Gaurav Pandey, Maithri Tharmavaram, Deepak Rawtani, Sumit Kumar, Y Agrawal
Forensic science is a wide field comprising of several subspecialties and uses methods derived from natural sciences for finding criminals and other evidence valid in a legal court. A relatively new area; Nano-forensics brings a new era of investigation in forensic science in which instantaneous results can be produced that determine various agents such as explosive gasses, biological agents and residues in different crime scenes and terrorist activity investigations. This can be achieved by applying Nanotechnology and its associated characterization techniques in forensic sciences...
February 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28214750/propagation-of-thickness-shear-waves-in-a-periodically-corrugated-quartz-crystal-plate-and-its-application-exploration-in-acoustic-wave-filters
#18
Peng Li, Li Cheng
The propagation of thickness shear waves in a periodically corrugated quartz crystal plate is investigated in the present paper using a power series expansion technique. In the proposed simulation model, an equivalent continuity of shear stress moment is introduced as an approximation to handle sectional interfaces with abrupt thickness changes. The Bloch theory is applied to simulate the band structures for three different thickness variation patterns. It is shown that the power series expansion method exhibits good convergence and accuracy, in agreement with results by finite element method (FEM)...
February 7, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28214745/rapid-detection-and-quantification-of-enterovirus-71-by-a-portable-surface-plasmon-resonance-biosensor
#19
Briliant Adhi Prabowo, Robert Y L Wang, Muhammad Khari Secario, Po-Ting Ou, Azharul Alom, Jia-Jung Liu, Kou-Chen Liu
This study presents the first report on a label-free detection and rapid quantification method for human enterovirus 71 (EV71) using a portable surface plasmon resonance (SPR) system. The SPR sensor instrument was configured to run on low power in a miniaturized platform to improve the device portability for a wider application both in laboratories and in the field. A color tunable organic light emitting diode in red spectrum was attached on a trapezoidal prism for the disposable light source module. The SPR signal processing using integration area under the reflectivity curve is applied for optimum signal to noise ratio (SNR) enhancement...
January 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28214733/flexible-camphor-diamond-like-carbon-coating-on-polyurethane-to-prevent-candida-albicans-biofilm-growth
#20
Thaisa B Santos, Angela A Vieira, Luciana O Paula, Everton D Santos, Polyana A Radi, Sônia Khouri, Homero S Maciel, Rodrigo S Pessoa, Lucia Vieira
Camphor was incorporated in diamond-like carbon (DLC) films to prevent the Candida albicans yeasts fouling on polyurethane substrates, which is a material commonly used for catheter manufacturing. The camphor:DLC and DLC film for this investigation was produced by plasma enhanced chemical vapor deposition (PECVD), using an apparatus based on the flash evaporation of organic liquid (hexane) containing diluted camphor for camphor:DLC and hexane/methane, mixture for DLC films. The film was deposited at a low temperature of less than 25°C...
February 16, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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