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https://www.readbyqxmd.com/read/29313574/a-study-of-genetic-markers-in-patients-of-rheumatoid-arthritis-and-their-co-relation-with-severity-of-the-disease
#1
Gauri Liyakat Ali, Suman Kapur, Sai Chinmayi, Qadir Fatima, Harshal Pise, Asim Khan, Ambreen Liyakat, V Jilova, Urvashi Dube
Introduction: Dyslipidemia has been reported to attribute to early death due to increased atherosclerosis leading to CVDs in patients with RA. Recent reports have suggested a role of adipocytokines in mediating joint damage rheumatoid arthritis (RA). RA has long been associated with increased cardiovascular risk as atherosclerosis is more prevalent in patients of RA than in the general population. Specific alleles of APOE gene have been reported to be associated with risk for atherosclerosis and LEP gene alleles have been associated with increased BMI...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29305946/a-whole-grain-diet-reduces-peripheral-insulin-resistance-and-improves-glucose-kinetics-in-obese-adults-a-randomized-controlled-trial
#2
Steven K Malin, Emily L Kullman, Amanda R Scelsi, Jacob M Haus, Julianne Filion, Mangesh R Pagadala, Jean-Philippe Godin, Sunil Kochhar, Alastair B Ross, John P Kirwan
BACKGROUND: Whole-grain intake is associated with lower risk of type 2 diabetes but mechanisms are unclear. PURPOSE: We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet. METHODS: A double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38±2 yrs.; BMI, 34.0±1.1kg/m2). Insulin resistance and glucose metabolism was assessed using an oral glucose tolerance test combined with isotopic tracers of [6,6-2H2]-glucose and [U-13C]-glucose, and indirect calorimetry...
January 3, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29249684/thyroid-hormones-lipid-profile-and-anthropometric-changes-after-programmed-weight-loss-in-palestinian-obese-adult-females
#3
Saleh Mwafy, Maged Yassin, Raed Mousa
OBJECTIVE: we aimed to investigate the changes in thyroid hormones, lipid profile and anthropometric measures after programmed weight loss in Palestinian obese adult females MATERIALS AND METHODS: This prospective study included 94 obese female (20-50 years old) as cases and 94 Non-obese of same age as controls for baseline comparisons. Obese female were assigned for low calorie diet (1200-1500 Kcal/day) in addition to a daily program of therapeutic exercise for six month. Parameters were measured, statistically analyzed and compared with control before and after study...
December 14, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29241640/association-of-anti-cyclic-citrullinated-protein-antibodies-erosions-and-rheumatoid-factor-with-disease-activity-and-work-productivity-a-patient-registry-study
#4
Evo Alemao, Zhenchao Guo, Michelle L Frits, Christine K Iannaccone, Nancy A Shadick, Michael E Weinblatt
OBJECTIVES: To evaluate associations between the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) and other outcomes, including joint erosions and both clinical and economic endpoints, in patients with rheumatoid arthritis (RA). METHODS: Data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS), a prospective registry of adult RA patients with established or recent-onset RA, were analyzed...
October 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29237149/association-of-antibodies-to-citrullinated-protein-antigens-with-blood-pressure-in-first-degree-relatives-of-rheumatoid-arthritis-patients-the-studies-of-the-etiology-of-rheumatoid-arthritis
#5
Jan M Hughes-Austin, Ryan W Gan, Kevin D Deane, Michael H Weisman, M Kristen Demoruelle, Jeremy Sokolove, William H Robinson, V Michael Holers, Jill M Norris, Joachim H Ix
BACKGROUND: Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications...
December 13, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29231278/are-obesity-and-rheumatoid-arthritis-interrelated
#6
Lior Dar, Shmuel Tiosano, Abdulla Watad, Nicola Luigi Bragazzi, Devi Zisman, Doron Comaneshter, Arnon Cohen, Howard Amital
OBJECTIVES: In recent years, both the prevalence of obesity and the incidence of RA have been rising. Our aim was to assess the association between overweight or obesity and rheumatoid arthritis (RA). DESIGN: Patients who were diagnosed with RA were compared with population-based controls, matched for age and sex (by a ratio of 1:5). Body measurements and smoking status were collected from medical records. Body mass index was classified in WHO categories of underweight, normal, overweight and obese (<18...
December 12, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29225253/an-analysis-of-the-neuropathic-pain-components-in-rheumatoid-arthritis-patients
#7
Satoshi Ito, Daisuke Kobayashi, Akira Murasawa, Ichiei Narita, Kiyoshi Nakazono
Objective To analyze the neuropathic pain (NeP) components in patients with rheumatoid arthritis (RA). Patients and Methods The pain DETECT questionnaire (PD-Q) was completed by 300 RA patients (79 men, 221 women). Results Nine patients (3.0%) were categorized as likely NeP, 33 (11.0%) were categorized as possible NeP, and 258 (86.0%) were categorized as unlikely NeP. When we excluded patients with diabetes mellitus, spinal diseases, neurological diseases, and herpes zoster infection (conditions associated with NeP), 5 of the patients (1...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29196084/characteristics-associated-with-the-choice-of-first-injectable-therapy-among-us-patients-with-type-2-diabetes
#8
Maria Yu, Reema Mody, Laura Fernández Landó, Amy Shui, Lee Kallenbach, Lukas Slipski, Carolina Piras de Oliveira
PURPOSE: The objective of this retrospective observational study was to describe and identify clinical and demographic characteristics associated with the choice of first injectable therapy (glucagon-like peptide-1 receptor agonist [GLP-1-RA] or basal insulin) among patients with type 2 diabetes mellitus (T2DM). METHODS: This analysis included adults naive to injectable therapy with T2DM who initiated a GLP-1-RA or basal insulin (index date) between November 2014 and February 2016 using data from the Practice Fusion Electronic Health Record database...
December 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29193840/overweight-and-obesity-reduce-the-likelihood-of-achieving-sustained-remission-in-early-rheumatoid-arthritis-results-from-the-canadian-early-arthritis-cohort-study
#9
Elizabeth Schulman, Susan J Bartlett, Orit Schieir, Kathleen M Andersen, Gilles Boire, Janet E Pope, Carol Hitchon, Shahin Jamal, Carter J Thorne, Diane Tin, Edward C Keystone, Boulos Haraoui, Susan M Goodman, Vivian P Bykerk, Catch Investigators
OBJECTIVE: Obesity is implicated in RA development, severity, outcomes and treatment response. We estimated the independent effects of overweight and obesity on ability to achieve sustained remission (sREM) in the three years following RA diagnosis. METHODS: Data were from the Canadian Early Arthritis Cohort, a multicenter observational trial of ERA patients treated by rheumatologists using guideline-based care. sREM was defined as DAS28 <2.6 for two consecutive visits...
November 30, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29121263/high-prevalence-of-diabetes-in-patients-with-rheumatoid-arthritis-results-from-a-questionnaire-survey-linked-to-claims-data
#10
Katinka Albrecht, Andres Luque Ramos, Falk Hoffmann, Imke Redeker, Angela Zink
Objectives: To investigate the prevalence of diabetes in patients with RA and the impact of diabetes on self-reported outcomes and health care. Methods: RA patients between the ages of 18 and 79 years were randomly selected from a nationwide statutory health insurance fund and were surveyed about rheumatological care and disease burden. Comorbid diabetes (E10-14) was analysed regarding age, sex, BMI and socioeconomic status. Disease burden, comorbidity and prescriptions were compared in RA patients with and without diabetes...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29116541/a-cross-sectional-study-of-vitamin-d-levels-in-a-large-cohort-of-patients-with-rheumatic-diseases
#11
Elena Nikiphorou, Jaakko Uksila, Tuulikki Sokka
The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011-April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29106754/right-heart-function-in-impaired-left-ventricular-diastolic-function-2d-speckle-tracking-echocardiography-based-and-doppler-tissue-imaging-based-analysis-of-right-atrial-and-ventricular-function
#12
Anna Brand, Marny Bathe, Sabine Oertelt-Prigione, Ute Seeland, Mirjam Rücke, Vera Regitz-Zagrosek, Karl Stangl, Fabian Knebel, Verena Stangl, Henryk Dreger
AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD). METHODS AND RESULTS: In a cross-sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE...
November 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/29105287/gut-microbiota-interacts-with-markers-of-adipose-tissue-browning-insulin-action-and-plasma-acetate-in-morbid-obesity
#13
José María Moreno-Navarrete, Matteo Serino, Vincent Blasco-Baque, Vincent Azalbert, Richard H Barton, Marina Cardellini, Jèssica Latorre, Francisco Ortega, Mònica Sabater-Masdeu, Rémy Burcelin, Marc-Emmanuel Dumas, Wifredo Ricart, Massimo Federici, José Manuel Fernández-Real
SCOPE: To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota and insulin sensitivity in humans. METHODS AND RESULTS: Gut microbiota composition and gene markers of browning were analysed in subcutaneous (SAT) and visceral (VAT) adipose tissue from morbidly obese subjects (n = 34). Plasma acetate was measured through (1) H NMR and insulin sensitivity using euglycemic hyperinsulinemic clamp. Subjects with insulin resistance showed an increase in the relative abundance (RA) of the phyla Bacteroidetes and Proteobacteria while RA of Firmicutes was decreased...
November 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29104376/anti-tnf-alpha-adalimumab-therapy-had-time-lag-of-improvement-in-synovial-hypertrophy-compared-to-rapid-response-in-power-doppler-synovial-vascularity
#14
Ying-Chou Chen, Chi-Hua Ko, Jia-Feng Chen, Chung-Yuan Hsu, Wen-Chan Chiu, Tien-Tsai Cheng
Objectives: The quantification of synovitis is of great significance for follow-up in patients with rheumatoid arthritis (RA). This study aimed to validate the use of power Doppler ultrasonography (PDUS) for evaluating synovial vascularity and synovial hypertrophy for synovitis in patients with rheumatoid arthritis treated with adalimumab. Materials and Methods: The synovial disease activity and vascularity of RA on both wrists (radio-carpal joint) were assessed using GS and PDUS to derive the composite US scores based on abnormal counts and severity...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29075504/recipients-and-providers-perspectives-of-obesity-and-potential-barriers-to-weight-management-programmes-in-patients-with-rheumatoid-arthritis-ra-a-qualitative-study
#15
G Colligan, J Galloway, H Lempp
BACKGROUND: The UK rheumatology community serves an ageing and ethnically diverse population, with a growing public health concern about obesity. Overweight and obesity contribute to 2.8 million preventable deaths annually. A raised Body Mass Index (BMI) in those with Rheumatoid Arthritis (RA) can have a significant negative impact on clinical outcomes. The aim of the study was to examine patients' and providers' perceptions of obesity and potential barriers to participation in a future weight management programme to contribute to an appropriate intervention design...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29046962/comparison-of-posterior-retroperitoneal-and-transabdominal-lateral-approaches-in-robotic-adrenalectomy-an-analysis-of-200-cases
#16
Bora Kahramangil, Eren Berber
BACKGROUND: Although numerous studies have been published on robotic adrenalectomy (RA) in the literature, none has done a comparison of posterior retroperitoneal (PR) and transabdominal lateral (TL) approaches. The aim of this study was to compare the outcomes of robotic PR and TL adrenalectomy. METHODS: This is a retrospective analysis of a prospectively maintained database. Between September 2008 and January 2017, perioperative outcomes of patients undergoing RA through PR and TL approaches were recorded into an IRB-approved database...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29029250/actigraphy-derived-daily-rest-activity-patterns-and-body-mass-index-in-community-dwelling-adults
#17
Elizabeth M Cespedes Feliciano, Mirja Quante, Jia Weng, Jonathan A Mitchell, Peter James, Catherine R Marinac, Sara Mariani, Susan Redline, Jacqueline Kerr, Suneeta Godbole, Alicia Manteiga, Daniel Wang, J Aaron Hipp
Study Objectives: To examine associations between 24-hour rest-activity patterns and body mass index (BMI) among community-dwelling U.S. adults. Rest-activity patterns provide a field method to study exposures related to circadian rhythms. Methods: Adults (N=578) wore an actigraph on their non-dominant wrist for 7 days. Intradaily variability and interdaily stability, M10 (most active 10-hours), L5 (least active 5-hours) and relative amplitude (RA) were derived using non-parametric rhythm analysis...
October 4, 2017: Sleep
https://www.readbyqxmd.com/read/29016785/obstructive-sleep-apnea-is-associated-with-increased-rotor-burden-in-patients-undergoing-focal-impulse-and-rotor-modification-guided-atrial-fibrillation-ablation
#18
Daniel J Friedman, Peter Liu, Adam S Barnett, Kristen Bova Campbell, Kevin P Jackson, Tristram D Bahnson, James P Daubert, Jonathan P Piccini
Aims: To assess whether obstructive sleep apnea (OSA) was associated with increased rotor burden among atrial fibrillation (AF) patients. Methods and results: We studied 33 consecutive patients who were scheduled for focal impulse and rotor modulation (FIRM) ablation at our institution to describe the mapping, ablation, and outcomes, among patients with and without OSA. Patients underwent biatrial FIRM mapping in AF with ablation of stable rotors in addition to conventional ablation lesion sets...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28993870/serum-serotonin-levels-and-bone-in-rheumatoid-arthritis-patients
#19
Miguel Bernardes, Tiago Vieira, Raquel Lucas, Jorge Pereira, Lúcia Costa, Francisco Simões-Ventura, Maria João Martins
In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample of 205 RA patients and related these to anthropometric variables, disease parameters, serum bone biomarkers, and bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry at several sites (total proximal femur, lumbar spine, left hand, and left second proximal phalange)...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28973022/the-impact-of-cardiovascular-risk-factors-on-cardiac-structure-and-function-insights-from-the-uk-biobank-imaging-enhancement-study
#20
Steffen E Petersen, Mihir M Sanghvi, Nay Aung, Jackie A Cooper, José Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M Lee, Valentina Carapella, Young Jin Kim, Stefan K Piechnik, Stefan Neubauer
AIMS: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. METHODS: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors...
2017: PloS One
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