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https://www.readbyqxmd.com/read/28796299/complement-c3-and-fatty-liver-disease-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#1
Francesco Ursini, Emilio Russo, Daniele Mauro, Ludovico Abenavoli, Giorgio Ammerata, Alfonso Serrao, Rosa Daniela Grembiale, Giovambattista De Sarro, Ignazio Olivieri, Salvatore D'Angelo
BACKGROUND: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of non-alcoholic fatty liver disease (NAFLD) in the general population. Aim of the present study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. MATERIALS AND METHODS: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28795508/occupation-and-risk-of-developing-rheumatoid-arthritis-results-from-a-population-based-case-control-study
#2
Anna Ilar, Lars Alfredsson, Pernilla Wiebert, Lars Klareskog, Camilla Bengtsson
OBJECTIVE: Environmental factors are of importance for the etiology of rheumatoid arthritis (RA), but much remains unknown concerning the contributions from distinct occupational hazards. We explored the association between occupation and the risk of anti-citrullinated protein antibody (ACPA) + RA or ACPA- RA. METHODS: We analyzed 3,522 cases and 5,580 controls from the Swedish population-based EIRA case-control study. A questionnaire was used to obtain information on work history and lifestyle factors...
August 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28758134/polymorphism-rs2073618-of-the-tnfrsf11b-opg-gene-and-bone-mineral-density-in-mexican-women-with-rheumatoid-arthritis
#3
C A Nava-Valdivia, A M Saldaña-Cruz, E G Corona-Sanchez, J D Murillo-Vazquez, M C Moran-Moguel, M Salazar-Paramo, E E Perez-Guerrero, M L Vazquez-Villegas, D Bonilla-Lara, A D Rocha-Muñoz, B T Martín-Marquez, F Sandoval-Garcia, E A Martínez-García, N S Fajardo-Robledo, J M Ponce-Guarneros, M Ramirez-Villafaña, M F Alcaraz-Lopez, L Gonzalez-Lopez, J I Gamez-Nava
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related to postmenopausal OP although, to date, no information has been described concerning whether this polymorphism is implied in abnormalities of bone mineral density (BMD) in RA. We evaluated, in a case-control study performed in Mexican-Mestizo women with RA, whether SNP rs2073618 in the TNFRSF11B gene is associated with a decrease in BMD...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28751150/prevalence-of-glucose-intolerance-in-rheumatoid-arthritis-patients-at-a-tertiary-care-centre-in-haryana
#4
Rajesh Rajput, Anoop Dangi, Harpreet Singh
AIMS: Recent studies have shown increasing prevalence of dysglycemia in rheumatoid arthritis (RA) patients. The present study was planned to study the prevalence of pre-diabetes and diabetes in RA patients from a tertiary care centre in Haryana, India. METHODS: 150 diagnosed cases of rheumatoid arthritis which were on follow up in Rheumatology clinic from last one year and equal number of age, sex matched controls were recruited for the study. FPG, 2h plasma glucose level after 75g oral glucose tolerance test and HbA1c were estimated in all the subjects...
July 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28748389/predisposing-factors-associated-with-atypical-femur-fracture-among-postmenopausal-korean-women-receiving-bisphosphonate-therapy-8%C3%A2-years-experience-in-a-single-center
#5
J H Koh, J P Myong, J Yoo, Y-W Lim, J Lee, S-K Kwok, S-H Park, J H Ju
The risk factors for atypical femur fracture in patients exposed to bisphosphonates for at least 1 year were examined. Prolonged and continuous use of bisphosphonates, long-term use of glucocorticoids, and a higher body mass index were associated with increased risk of atypical femur fracture. INTRODUCTION: The purpose of the present study is to determine whether rheumatoid arthritis (RA) and other clinical factors are associated with an increased risk of bisphosphonate (BP)-related atypical femur fracture (AFF)...
July 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28743353/which-is-the-best-cutoff-of-body-mass-index-to-identify-obesity-in-female-patients-with-rheumatoid-arthritis-a-study-using-dual-energy-x-ray-absorptiometry-body-composition
#6
Maria Fernanda B Resende Guimarães, Maria Raquel da Costa Pinto, Renata G Santos Couto Raid, Marcus Vinícius Melo de Andrade, Adriana Maria Kakehasi
INTRODUCTION: Standard anthropometric measures used to diagnose obesity in the general population may not have the same performance in patients with rheumatoid arthritis. OBJECTIVE: To determine cutoff points for body mass index (BMI) and waist circumference (WC) for detecting obesity in women with rheumatoid arthritis (RA) by comparing these standard anthropometric measures to a dual-energy X-ray absorptiometry (DXA)-based obesity criterion. PATIENTS AND METHOD: Adult female patients with more than six months of diagnosis of RA underwent clinical evaluation, with anthropometric measures and body composition with DXA...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28713554/growth-hormone-receptor-antagonism-with-pegvisomant-in-insulin-resistant-non-diabetic-men-a-phase-ii-pilot-study
#7
Ada P Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J Murphy, Ethan J Weiss
Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men.  Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m (2), with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily...
2017: F1000Research
https://www.readbyqxmd.com/read/28702765/association-between-serum-plasma-adiponectin-levels-and-immune-mediated-diseases-a-meta-analysis
#8
Ming-Yue Zhang, Ahmed Ali Dini, Xiao-Ke Yang, Lian-Ju Li, Guo-Cui Wu, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
Adiponectin plays an important role in the development of immune-mediated diseases. Currently published data regarding the relationship between serum/plasma levels of adiponectin and immune-mediated diseases are inconsistent. We therefore conducted this meta-analysis to explore the association of serum/plasma adiponectin levels with immune-mediated diseases in humans. Systematic literature search was conducted to identify all relevant studies. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis...
July 12, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28698901/circulating-osteoprotegerin-levels-are-elevated-in-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#9
Peng Wang, Si Li, Li-Na Liu, Tian-Tian Lv, Xiao-Mei Li, Xiang-Pei Li, Hai-Feng Pan
This study aimed to systemically review the evidence regarding the relationship between the circulating blood osteoprotegerin (OPG) level and rheumatoid arthritis (RA), as well as the potential influential factors. Research related to plasma/serum OPG levels in RA patients and healthy controls were gathered using PubMed, EMBASE, and The Cochrane Library database (up to Jan. 1, 2017). Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis...
July 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28679624/factors-regulating-subcutaneous-adipose-tissue-storage-fibrosis-and-inflammation-may-underlie-low-fatty-acid-mobilization-in-insulin-sensitive-obese-adults
#10
Douglas W Van Pelt, Lisa M Guth, Abigail Y Wang, Jeffrey F Horowitz
Although the rate of fatty acid release from adipose tissue into the systemic circulation is very high in most obese adults, some obese adults maintain relatively low rates of fatty acid release, which helps protect them against the development of systemic insulin resistance. The primary aim of this study was to identify factors in adipose tissue that may underlie low vs. high rates of fatty acid mobilization in a relatively homogeneous cohort of obese adults. We measured systemic fatty acid rate of appearance (FA Ra) via (13)C-palmitate isotope dilution, and we obtained subcutaneous abdominal adipose tissue samples from 30 obese adults (BMI: 38±1 kg/m(2), age: 30±2 yr) after an overnight fast...
July 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28666478/cardiovascular-risk-factors-predate-the-onset-of-symptoms-of-rheumatoid-arthritis-a-nested-case-control-study
#11
Heidi Kokkonen, Hans Stenlund, Solbritt Rantapää-Dahlqvist
BACKGROUND: Patients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular disease (CVD). Our aim was to evaluate the impact of factors related to CVD, such as smoking, lipid levels, hypertension, body mass index (BMI) and diabetes, in individuals prior to the onset of symptoms of RA. METHODS: A nested case-control study was performed including data from 547 pre-symptomatic individuals (i.e. individuals who had participated in population surveys in northern Sweden prior to onset of symptoms of RA, median time to symptom onset 5...
June 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28656048/evaluation-of-vitamin-d-status-in-rheumatoid-arthritis-and-its-association-with-disease-activity-across-15-countries-the-comora-study
#12
Najia Hajjaj-Hassouni, Nada Mawani, Fadoua Allali, Hanan Rkain, Kenza Hassouni, Ihsane Hmamouchi, Maxime Dougados
The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 [0.1-151]. Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients. 43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (p < 0...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28646162/associations-between-global-dna-methylation-and-telomere-length-in-healthy-adolescents
#13
Yutong Dong, Ying Huang, Bernard Gutin, Anas Raed, Yanbin Dong, Haidong Zhu
Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte telomere length (LTL) was defined as relative telomere to single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age, gender, ethnicity, Tanner stage, BMI, PA, and batch effect, revealed that %5 mC was associated with LTL (adjusted β = 0...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630578/are-change-of-direction-speed-and-reactive-agility-useful-for-determining-the-optimal-field-position-for-young-soccer-players
#14
Giovanni Fiorilli, Enzo Iuliano, Michalis Mitrotasios, Eugenio M Pistone, Giovanna Aquino, Giuseppe Calcagno, Alessandra di Cagno
Change Of Direction Speed (CODS) and Reactive Agility (RA) are two determining factors in the ability of young soccer players. We aimed to verify if CODS and RA could be useful in order to establish the best young soccer player field position. Ninety-two elite soccer players (15.18 ± 1.21 years, weight 59.18 ± 9.93, height 1.72 ± 0.08, BMI 19.76 ± 2.22), belonging to two youth categories from the Italian First and Second Divisions, volunteered in this study. The participants included 32 defenders (15.06 ± 0...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28594905/comparative-risk-of-hospitalized-infection-between-biological-agents-in-rheumatoid-arthritis-patients-a-multicenter-retrospective-cohort-study-in-japan
#15
Shunsuke Mori, Tamami Yoshitama, Toshihiko Hidaka, Fumikazu Sakai, Mizue Hasegawa, Yayoi Hashiba, Eiichi Suematsu, Hiroshi Tatsukawa, Akinari Mizokami, Shigeru Yoshizawa, Naoyuki Hirakata, Yukitaka Ueki
OBJECTIVE: Knowing the risk of hospitalized infection associated with individual biological agents is an important factor in selecting the best treatment option for patients with rheumatoid arthritis (RA). This study examined the comparative risk of hospitalized infection between biological agents in a routine care setting. METHODS: We used data for all RA patients who had first begun biological therapy at rheumatology divisions of participating community hospitals in Japan between January 2009 and December 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28569167/increased-serum-concentrations-of-il-1-beta-il-21-and-th17-cells-in-overweight-patients-with-rheumatoid-arthritis
#16
Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Keiichi Sakurai, Shuji Sumitomo, Keishi Fujio, Kazuhiko Yamamoto
BACKGROUNDS: Obesity is associated with worse disease activity and drug responses in patients with rheumatoid arthritis (RA). However, the immunological mechanisms responsible for the relationship between RA and obesity have not yet been clarified in detail. This study aimed to elucidate the immunological mechanisms contributing to the pathogenesis of RA in overweight patients. METHODS: The frequencies of CD4(+) T cell, B cell and monocyte subsets were analyzed in RA (n = 81) and healthy donors (n = 99) by flow cytometry, and were compared between three groups (body mass index (BMI) <20,  ≥20 to 25, >25)...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28549731/clinical-and-sonographic-biomarkers-of-structural-damage-progression-in-ra-patients-in-clinical-remission-a-prospective-study-with-12-months-follow-up
#17
Julio Ramírez, José Antonio Narváez, Virginia Ruiz-Esquide, Javier Hernández-Gañán, Andrea Cuervo, José Inciarte-Mundo, Maria Victoria Hernández, Miguel Sampayo-Cordero, José Luis Pablos, Raimon Sanmartí, Juan D Cañete
OBJECTIVE: To determine clinical and sonographic biomarkers predicting structural damage progression at 12 months of follow-up as measured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients in clinical remission. PATIENTS AND METHODS: We included patients with RA in clinical remission, defined as 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for >6 months. Ultrasound scans of both hands and knees and MRI of the dominant hand were performed at baseline and at 12 months...
May 1, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28486047/prevalence-of-metabolic-syndrome-in-rheumatoid-arthritis-patients-from-northeastern-brazil-association-with-disease-activity
#18
Kirla Wagner Poti Gomes, Ana Joicy Pinheiro Luz, Marcos Rainier de Brito Felipe, Lara Amorim Beltrão, André Xenofonte Cartaxo Sampaio, Carlos Ewerton Maia Rodrigues
OBJECTIVES: To determine the prevalence of metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) and controls from Northeastern Brazil and to verify its association with specific RA parameters and cardiovascular risk factors. METHODS: The prevalence of MetS was assessed cross-sectionally in 338 RA patients from a single center and 84 age and gender-matched controls from the local community. MetS was defined according to NCEP/ATPIII guidelines. Disease activity was assessed with CDAI, SDAI and DAS28 scores...
May 9, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28482146/skeletal-muscle-fat-and-its-association-with-physical-function-in-rheumatoid-arthritis
#19
Samannaaz S Khoja, Charity G Moore, Bret H Goodpaster, Anthony Delitto, Sara R Piva
OBJECTIVE: To characterize skeletal muscle fat (SMF), intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) in individuals with rheumatoid arthritis (RA), and assess the associations between these fat depots and physical function and physical activity. METHODS: Cross-sectional analysis from an RA cohort. SMF, IMAT and SAT were measured using computed tomography imaging of the mid-thigh cross-sectional region. Physical function was measured with the Health Assessment Questionnaire (HAQ) and a battery of performance-based tests that included quadriceps muscle strength, gait speed, repeated chair-stands, stair ascend, and single leg-stance...
May 8, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28426913/body-mass-index-weight-loss-and-cause-specific-mortality-in-rheumatoid-arthritis
#20
Bryant R England, Joshua F Baker, Harlan Sayles, Kaleb Michaud, Liron Caplan, Lisa A Davis, Grant W Cannon, Brian C Sauer, E Blair Solow, Andreas M Reimold, Gail S Kerr, Ted R Mikuls
OBJECTIVES: To examine associations of body mass index (BMI) and weight loss with cause-specific mortality in rheumatoid arthritis (RA). METHODS: A cohort of U.S. Veterans with RA were followed until death or through 2013. BMI was categorized as underweight, normal, overweight, and obese. Weight loss was calculated as the: 1) annualized rate of change over the preceding 13 months and 2) cumulative percent. Vital status and cause of death were obtained from the National Death Index...
April 20, 2017: Arthritis Care & Research
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