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https://www.readbyqxmd.com/read/28938465/serum-insulin-bioassay-reflects-insulin-sensitivity-and-requirements-in-type-1-diabetes
#1
Joseph A M J L Janssen, Gemma Llauradó, Aimee J Varewijck, Per-Henrik Groop, Carol Forsblom, Sonia Fernández-Veledo, Elisabeth S R van den Dungen, Joan Vendrell, Leo J Hofland, Hannele Yki-Järvinen
Background: Insulin resistance could increase insulin requirements in type 1 diabetes (TD1). Current insulin immunoassays do not detect insulin analogues. Kinase Insulin Receptor Activation (KIRA) bioassays specific for human insulin receptor isoforms A and B (IR-A and IR-B) permit assessment of all circulating insulin bioactivity. We studied whether IR-A and IR-B KIRA assays are related to direct measures of insulin sensitivity or insulin doses in TD1. Methods: We evaluated 31 adult patients with TD1 (age 45...
August 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28916544/muscle-deficits-in-rheumatoid-arthritis-contribute-to-inferior-cortical-bone-structure-and-trabecular-bone-mineral-density
#2
Joshua F Baker, Jin Long, Sogol Mostoufi-Moab, Michele Denburg, Erik Jorgenson, Prerna Sharma, Babette S Zemel, Elena Taratuta, Said Ibrahim, Mary B Leonard
OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. METHODS: Participants, ages 18-75 years, completed whole-body dual-energy x-ray absorptiometry and peripheral quantitative computed tomography (pQCT) of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI), muscle density at the lower leg, trabecular bone density, and cortical bone thickness...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28880707/relationship-between-achievement-of-physical-activity-goal-and-characteristics-of-patients-with-rheumatoid-arthritis
#3
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Shigeki Momohara
OBJECTIVES: We aimed to identify the relationship between achievement of a physical activity goal and the characteristics of patients with rheumatoid arthritis (RA). METHODS: Overall, 137 patients with RA who performed physical activity were enrolled. Statistical analysis was performed to examine relationship between patient characteristics and achievement of physical activity goal by univariate analysis, multivariate logistic regression analysis and the receiver operating characteristic method...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28879052/obesity-is-a-strong-predictor-of-worse-clinical-outcomes-and-treatment-responses-in-early-rheumatoid-arthritis-results-from-the-swefot-trial
#4
Adrian Levitsky, Kerstin Brismar, Ingiäld Hafström, Karen Hambardzumyan, Cecilia Lourdudoss, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVES: The aim of this paper was to analyse the impact of obesity, in addition to known predictors, on disease outcome in early rheumatoid arthritis (RA). METHODS: Body mass index (BMI) was available in 260 patients from the Swedish pharmacotherapy trial (SWEFOT). Differences in disease activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese BMI >30, n=43; overweight BMI=25-29...
2017: RMD Open
https://www.readbyqxmd.com/read/28870033/-the-expression-and-clinical-significance-of-proprotein-convertase-subtilisin-kexin-9-in-rheumatoid-arthritis
#5
Q Du, X J Yu, H J Li, S Q Guan, Z Y Zhang, Y F Mei
Objective: To assess the expression and significance of proprotein convertase subtilisin kexin 9 (PCSK9) in patients with rheumatoid arthritis (RA). Methods: Sixty-five RA patients and forty-seven healthy controls were recruited in this study. The body mass index (BMI) and serum total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), lipoprotein a, low density lipoprotein(LDL), very low density lipoprotein(VLDL), apolipoprotein A(ApoA), apolipoprotein B(ApoB) and the ratio of LDL-C/HDL-C were tested...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#6
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28834907/prevalence-of-type-2-diabetes-and-impaired-fasting-glucose-in-patients-affected-by-rheumatoid-arthritis-results-from-a-cross-sectional-study
#7
Piero Ruscitti, Francesco Ursini, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Francesco Carubbi, Giuliana Guggino, Onorina Berardicurti, Rosadaniela Grembiale, Giovanni Triolo, Giovambattista De Sarro, Roberto Giacomelli
Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28822046/body-mass-index-and-clinical-response-to-intravenous-or-subcutaneous-abatacept-in-patients-with-rheumatoid-arthritis
#8
Maria-Antonietta D'Agostino, Rieke Alten, Eduardo Mysler, Manuela Le Bars, June Ye, Bindu Murthy, Julia Heitzmann, Radu Vadanici, Gianfranco Ferraccioli
This post hoc analysis of ACQUIRE (NCT00559585) explored the effect of baseline body mass index (BMI) on the pharmacokinetics of and clinical response to subcutaneous (SC) or intravenous (IV) abatacept in patients with rheumatoid arthritis (RA). ACQUIRE was a phase 3b, 6-month, double-blind, double-dummy study in which patients with RA were randomized (1:1) to SC (fixed - dose; 125 mg/week) or IV (weight-tiered; ~ 10 mg/kg/month) abatacept plus methotrexate. In this analysis, minimum abatacept plasma concentration (Cmin) was measured at 3 and 6 months, and clinical remission over 6 months was assessed by Disease Activity Score 28 (C-reactive protein; DAS28 [CRP], < 2...
August 18, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28796299/complement-c3-and-fatty-liver-disease-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#9
Francesco Ursini, Emilio Russo, Daniele Mauro, Ludovico Abenavoli, Giorgio Ammerata, Alfonso Serrao, Rosa Daniela Grembiale, Giovambattista De Sarro, Ignazio Olivieri, Salvatore D'Angelo
BACKGROUND: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of non-alcoholic fatty liver disease (NAFLD) in the general population. Aim of the present study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. MATERIALS AND METHODS: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28795508/occupation-and-risk-of-developing-rheumatoid-arthritis-results-from-a-population-based-case-control-study
#10
Anna Ilar, Lars Alfredsson, Pernilla Wiebert, Lars Klareskog, Camilla Bengtsson
OBJECTIVE: Environmental factors are of importance for the etiology of rheumatoid arthritis (RA), but much remains unknown concerning the contributions from distinct occupational hazards. We explored the association between occupation and the risk of anti-citrullinated protein antibody (ACPA) + RA or ACPA- RA. METHODS: We analyzed 3,522 cases and 5,580 controls from the Swedish population-based EIRA case-control study. A questionnaire was used to obtain information on work history and lifestyle factors...
August 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28758134/polymorphism-rs2073618-of-the-tnfrsf11b-opg-gene-and-bone-mineral-density-in-mexican-women-with-rheumatoid-arthritis
#11
C A Nava-Valdivia, A M Saldaña-Cruz, E G Corona-Sanchez, J D Murillo-Vazquez, M C Moran-Moguel, M Salazar-Paramo, E E Perez-Guerrero, M L Vazquez-Villegas, D Bonilla-Lara, A D Rocha-Muñoz, B T Martín-Marquez, F Sandoval-Garcia, E A Martínez-García, N S Fajardo-Robledo, J M Ponce-Guarneros, M Ramirez-Villafaña, M F Alcaraz-Lopez, L Gonzalez-Lopez, J I Gamez-Nava
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related to postmenopausal OP although, to date, no information has been described concerning whether this polymorphism is implied in abnormalities of bone mineral density (BMD) in RA. We evaluated, in a case-control study performed in Mexican-Mestizo women with RA, whether SNP rs2073618 in the TNFRSF11B gene is associated with a decrease in BMD...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28751150/prevalence-of-glucose-intolerance-in-rheumatoid-arthritis-patients-at-a-tertiary-care-centre-in-haryana
#12
Rajesh Rajput, Anoop Dangi, Harpreet Singh
AIMS: Recent studies have shown increasing prevalence of dysglycemia in rheumatoid arthritis (RA) patients. The present study was planned to study the prevalence of pre-diabetes and diabetes in RA patients from a tertiary care centre in Haryana, India. METHODS: 150 diagnosed cases of rheumatoid arthritis which were on follow up in Rheumatology clinic from last one year and equal number of age, sex matched controls were recruited for the study. FPG, 2h plasma glucose level after 75g oral glucose tolerance test and HbA1c were estimated in all the subjects...
July 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28748389/predisposing-factors-associated-with-atypical-femur-fracture-among-postmenopausal-korean-women-receiving-bisphosphonate-therapy-8%C3%A2-years-experience-in-a-single-center
#13
J H Koh, J P Myong, J Yoo, Y-W Lim, J Lee, S-K Kwok, S-H Park, J H Ju
The risk factors for atypical femur fracture in patients exposed to bisphosphonates for at least 1 year were examined. Prolonged and continuous use of bisphosphonates, long-term use of glucocorticoids, and a higher body mass index were associated with increased risk of atypical femur fracture. INTRODUCTION: The purpose of the present study is to determine whether rheumatoid arthritis (RA) and other clinical factors are associated with an increased risk of bisphosphonate (BP)-related atypical femur fracture (AFF)...
July 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28743353/which-is-the-best-cutoff-of-body-mass-index-to-identify-obesity-in-female-patients-with-rheumatoid-arthritis-a-study-using-dual-energy-x-ray-absorptiometry-body-composition
#14
Maria Fernanda B Resende Guimarães, Maria Raquel da Costa Pinto, Renata G Santos Couto Raid, Marcus Vinícius Melo de Andrade, Adriana Maria Kakehasi
INTRODUCTION: Standard anthropometric measures used to diagnose obesity in the general population may not have the same performance in patients with rheumatoid arthritis. OBJECTIVE: To determine cutoff points for body mass index (BMI) and waist circumference (WC) for detecting obesity in women with rheumatoid arthritis (RA) by comparing these standard anthropometric measures to a dual-energy X-ray absorptiometry (DXA)-based obesity criterion. PATIENTS AND METHOD: Adult female patients with more than six months of diagnosis of RA underwent clinical evaluation, with anthropometric measures and body composition with DXA...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28713554/growth-hormone-receptor-antagonism-with-pegvisomant-in-insulin-resistant-non-diabetic-men-a-phase-ii-pilot-study
#15
Ada P Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J Murphy, Ethan J Weiss
Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men.  Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m (2), with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily...
2017: F1000Research
https://www.readbyqxmd.com/read/28702765/association-between-serum-plasma-adiponectin-levels-and-immune-mediated-diseases-a-meta-analysis
#16
Ming-Yue Zhang, Ahmed Ali Dini, Xiao-Ke Yang, Lian-Ju Li, Guo-Cui Wu, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
Adiponectin plays an important role in the development of immune-mediated diseases. Currently published data regarding the relationship between serum/plasma levels of adiponectin and immune-mediated diseases are inconsistent. We therefore conducted this meta-analysis to explore the association of serum/plasma adiponectin levels with immune-mediated diseases in humans. Systematic literature search was conducted to identify all relevant studies. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis...
July 12, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28698901/circulating-osteoprotegerin-levels-are-elevated-in-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#17
Peng Wang, Si Li, Li-Na Liu, Tian-Tian Lv, Xiao-Mei Li, Xiang-Pei Li, Hai-Feng Pan
This study aimed to systemically review the evidence regarding the relationship between the circulating blood osteoprotegerin (OPG) level and rheumatoid arthritis (RA), as well as the potential influential factors. Research related to plasma/serum OPG levels in RA patients and healthy controls were gathered using PubMed, EMBASE, and The Cochrane Library database (up to Jan. 1, 2017). Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis...
July 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28679624/factors-regulating-subcutaneous-adipose-tissue-storage-fibrosis-and-inflammation-may-underlie-low-fatty-acid-mobilization-in-insulin-sensitive-obese-adults
#18
Douglas W Van Pelt, Lisa M Guth, Abigail Y Wang, Jeffrey F Horowitz
Although the rate of fatty acid release from adipose tissue into the systemic circulation is very high in most obese adults, some obese adults maintain relatively low rates of fatty acid release, which helps protect them against the development of systemic insulin resistance. The primary aim of this study was to identify factors in adipose tissue that may underlie low vs. high rates of fatty acid mobilization in a relatively homogeneous cohort of obese adults. We measured systemic fatty acid rate of appearance (FA Ra) via (13)C-palmitate isotope dilution, and we obtained subcutaneous abdominal adipose tissue samples from 30 obese adults (BMI: 38±1 kg/m(2), age: 30±2 yr) after an overnight fast...
July 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28666478/cardiovascular-risk-factors-predate-the-onset-of-symptoms-of-rheumatoid-arthritis-a-nested-case-control-study
#19
Heidi Kokkonen, Hans Stenlund, Solbritt Rantapää-Dahlqvist
BACKGROUND: Patients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular disease (CVD). Our aim was to evaluate the impact of factors related to CVD, such as smoking, lipid levels, hypertension, body mass index (BMI) and diabetes, in individuals prior to the onset of symptoms of RA. METHODS: A nested case-control study was performed including data from 547 pre-symptomatic individuals (i.e. individuals who had participated in population surveys in northern Sweden prior to onset of symptoms of RA, median time to symptom onset 5...
June 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28656048/evaluation-of-vitamin-d-status-in-rheumatoid-arthritis-and-its-association-with-disease-activity-across-15-countries-the-comora-study
#20
Najia Hajjaj-Hassouni, Nada Mawani, Fadoua Allali, Hanan Rkain, Kenza Hassouni, Ihsane Hmamouchi, Maxime Dougados
The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 [0.1-151]. Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients. 43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (p < 0...
2017: International Journal of Rheumatology
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