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https://www.readbyqxmd.com/read/28073685/obesity-is-the-main-determinant-of-insulin-resistance-more-than-the-circulating-pro-inflammatory-cytokines-levels-in-rheumatoid-arthritis-patients
#1
Jesus Castillo-Hernandez, Martha Imelda Maldonado-Cervantes, Juan Pablo Reyes, Nuria Patiño-Marin, Enrique Maldonado-Cervantes, Claudia Solorzano-Rodriguez, Esperanza de la Cruz Mendoza, Brenda Alvarado-Sanchez
BACKGROUND: Systemic blockade of TNF-α in Rheumatoid arthritis (RA) with insulin resistance (IR) seems to produce more improvement in insulin sensitivity in normal weight patients with RA than in obese patients with RA, suggesting that systemic-inflammation and obesity are independent risk factors for IR in RA patients. OBJECTIVES: To evaluate the insulin resistance in: normal weight patients with RA (RA NW), overweight patients with RA (RA OW), obese RA patients (RA OB), and matched control subjects with normal weight (NW) and obesity (OB); and its association with major cytokines involved in the pathogenesis of the disease...
December 20, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28049882/the-relationship-between-circulating-neutrophil-gelatinase-associated-lipocalin-and-early-alteration-of-metabolic-parameters-is-associated-with-dietary-saturated-fat-intake-in-non-diabetic-korean-women
#2
Ga Yoon Na, So Ra Yoon, Juhyun An, Rimkyo Yeo, Juhyun Song, Mi-Na Jo, Seongho Han, Oh Yoen Kim
Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF≥1]...
December 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/28043761/the-effect-of-body-mass-index-on-clinical-response-to-abatacept-as-a-first-line-biologic-for-rheumatoid-arthritis-6-month-results-from-the-2-year-observational-prospective-action-study
#3
Xavier Mariette, Rieke Alten, Hubert G Nüßlein, Mauro Galeazzi, Hanns-Martin Lorenz, Alain Cantagrel, Melanie Chartier, Coralie Poncet, Christiane Rauch, Manuela Le Bars
OBJECTIVE: To assess the impact of baseline body mass index (BMI) on the efficacy and retention of intravenous abatacept at 6 months in biologic-naïve patients with rheumatoid arthritis (RA). METHODS: This was a 6-month analysis of a 2-year, non-interventional, international, prospective study. Baseline characteristics, clinical response and retention rates were compared by BMI subgroup: underweight/normal, overweight and obese (<25, 25 to <30 and ≥30kg/m(2), respectively)...
December 30, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28028684/are-obesity-acpas-and-periodontitis-conditions-that-influence-the-risk-of-developing-rheumatoid-arthritis-in-first-degree-relatives
#4
Sonia Unriza-Puin, Wilson Bautista-Molano, Gloria I Lafaurie, Rafael Valle-Oñate, Philippe Chalem, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sánchez
The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P...
December 28, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27994266/secretory-activity-of-subcutaneous-abdominal-adipose-tissue-in-male-patients-with-rheumatoid-arthritis-and-osteoarthritis-association-with-clinical-and-laboratory-data
#5
Ewa Kontny, Agnieszka Zielińska, Krystyna Księżopolska-Orłowska, Piotr Głuszko
INTRODUCTION: Adipose tissue exerts widespread effects on the metabolism and immune system, but its activity differs between the genders. In the general population low-grade adipose tissue inflammation contributes to development of diseases of affluence. Little is known about the systemic impact of peripheral fat tissue in osteoarthritis (OA) and rheumatoid arthritis (RA), characterized by chronic, low- and high-grade systemic inflammation, respectively. To clarify this we evaluated the secretory activity of subcutaneous abdominal adipose tissue (SAAT) obtained from male patients affected with RA (n = 21) and OA (n = 13), and assessed its association with body mass and composition, demographic, clinical and laboratory data...
2016: Reumatologia
https://www.readbyqxmd.com/read/27981248/absence-of-a-positive-correlation-between-crp-and-leptin-in-rheumatoid-arthritis
#6
Seyed Reza Najafizadeh, Ghasem Farahmand, Ahmad Tahamoli Roudsari, Behnam Heidari, Mehrdad Larry, Arash Aghajani Nargesi, Atieh Pajouhi, Alireza Esteghamati, Manouchehr Nakhjavani
AIMS: Rheumatoid Arthritis (RA) is a model of chronic inflammatory disease. In this study we evaluated the correlation of leptin and CRP in patients with RA and normal controls. MAIN METHODS: A total of 75 patients with RA and 40 healthy adults were recruited in this case-control study. RA patients were categorized into high (DAS-28 > 3.2) and low activity (DAS ≤ 3.2) group according to their DAS-28 score. KEY FINDINGS: Leptin level was significantly correlated with CRP in healthy controls (r = 0...
December 2016: Heliyon
https://www.readbyqxmd.com/read/27966068/body-mass-does-not-impact-the-clinical-response-to-intravenous-abatacept-in-patients-with-rheumatoid-arthritis-analysis-from-the-pan-european-registry-collaboration-for-abatacept-panaba
#7
Florenzo Iannone, Delphine S Courvoisier, Jacques Eric Gottenberg, Maria Victoria Hernandez, Elisabeth Lie, Helena Canhão, Karel Pavelka, Merete Lund Hetland, Carl Turesson, Xavier Mariette, Denis Choquette, Axel Finckh
Some evidences suggest that obesity impairs the effectiveness of TNF inhibitors. We examined the impact of body mass index (BMI) on the clinical effectiveness of abatacept in rheumatoid arthritis (RA) patients. This is a pooled analysis of 10 prospective cohorts of RA patients. All patients with available BMI were included in this study. The primary endpoint was drug retention of abatacept in the different BMI categories. Multivariable Cox regression was used to estimate hazard ratios (HRs) for drug discontinuation...
December 14, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27939764/elevated-bmi-and-antibodies-to-citrullinated-proteins-interact-to-increase-rheumatoid-arthritis-risk-and-shorten-time-to-diagnosis-a-nested-case-control-study-of-women-in-the-nurses-health-studies
#8
Sara K Tedeschi, Jing Cui, Elizabeth V Arkema, William H Robinson, Jeremy Sokolove, Nithya Lingampalli, Jeffrey A Sparks, Elizabeth W Karlson, Karen H Costenbader
OBJECTIVE: Overweight/obesity and anti-citrullinated protein antibodies (ACPA) increase rheumatoid arthritis (RA) risk. We investigated the relationship between body mass index (BMI) and ACPA, tested for an interaction between BMI and ACPA for RA risk, and examined effects of BMI and ACPA on time to RA diagnosis. DESIGN: Within the Nurses' Health Studies, blood samples were collected before diagnosis from medical record-confirmed incident RA cases and matched controls...
September 13, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27922752/abnormal-glucose-metabolism-and-high-energy-expenditure-in-idiopathic-pulmonary-arterial-hypertension
#9
Gustavo A Heresi, Steven K Malin, Jarrod W Barnes, Liping Tian, John P Kirwan, Raed A Dweik
RATIONALE: Insulin resistance has emerged as a potential mechanism related to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). However, direct measurements of insulin and glucose metabolism have not been performed in IPAH patients to date. OBJECTIVES: To perform comprehensive metabolic phenotyping on humans with IPAH. METHODS: We assessed plasma insulin and glucose using an oral glucose tolerance test and estimated insulin resistance and beta-cell function in 14 IPAH patients and 14 controls matched for age, sex, blood pressure, and body mass index (BMI),...
December 6, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27913575/lowest-glucose-variability-and-hypoglycemia-are-observed-with-the-combination-of-a-glp-1-receptor-agonist-and-basal-insulin-variation-study
#10
Harpreet S Bajaj, Karri Venn, Chenglin Ye, Avril Patrick, Shivani Kalra, Hasnain Khandwala, Nadeem Aslam, David Twum-Barima, Ronnie Aronson
OBJECTIVE: There is a dearth of published literature comparing glucose variability (GV) between different insulin regimens in type 2 diabetes. This cohort study compares GV using continuous glucose monitoring (CGM) in patients with well-controlled type 2 diabetes using four common insulin regimens: basal insulin + oral drugs (BO), basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), premixed insulin (PM), and basal-bolus insulin (BB). RESEARCH DESIGN AND METHODS: Consecutive patients from three endocrinology clinics who met study criteria-type 2 diabetes, age 18 to 80 years, BMI ≤ 45 kg/m(2), stable insulin regimen for a minimum of 6 months, and stable A1C value ≤7...
December 2, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27908300/serum-complement-c3-strongly-correlates-with-whole-body-insulin-sensitivity-in-rheumatoid-arthritis
#11
Francesco Ursini, Salvatore D'Angelo, Emilio Russo, Franco Arturi, Lucia D'Antona, Caterina Bruno, Saverio Naty, Giovambattista De Sarro, Ignazio Olivieri, Rosa Daniela Grembiale
OBJECTIVES: Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammatory measures and insulin sensitivity in RA patients. METHODS: Forty non-diabetic RA patients (19 males) were recruited. All patients underwent anthropometric measurements, laboratory evaluation and oral glucose tolerance test (OGTT)...
October 27, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27894341/abdominal-obesity-gender-and-the-risk-of-rheumatoid-arthritis-a-nested-case-control-study
#12
Lotta Ljung, Solbritt Rantapää-Dahlqvist
BACKGROUND: The risk of development of rheumatoid arthritis (RA) could be affected by immune activation in obesity. Our objective was to evaluate the association between obesity in general, and abdominal obesity, and the risk for subsequent development of RA. METHODS: In two large population-based, prospective cohorts, 557 cases (mean age at RA symptom onset 58, SD 10 years, 68% women) who subsequently developed RA and 1671 matched controls were identified. From a health examination antedating symptom onset (median 5...
November 29, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27801338/-the-correlations-of-single-photon-emission-computed-tomography-joints-scan-and-bone-metabolic-markers-in-active-rheumatoid-arthritis
#13
H Y Gao, X F Li, B N Zhang, M H Ding, D S Zhao
Objective: To explore the correlation between quantitative value of joint bone scan by single photon emission computed tomography(SPECT) and serum bone metabolic markers in patients with active rheumatoid arthritis(RA). Method: Clinical data of 60 newly diagnosed RA patients were retrospectively collected in Department of Rheumatology and Immunology from May 2013 to December 2014, including 28 cases with medical history less than 6 months and 32 from 6 months to 2 years. Serum C-terminal telopeptide of type Ⅰ collgen(CTX-Ⅰ)and N-terminal propeptide of type Ⅰ collagen(PINP)were tested by chemiluminesence...
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27792120/factors-that-predict-risk-of-cervical-instability-in-rheumatoid-arthritis-patients
#14
Myung-Hoon Han, Je Il Ryu, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Koang Hum Bak, Hyoung Joon Chun, Hyeong-Joong Yi, Jae Bum Jun, Jae Woo Chung
STUDY DESIGN: Retrospective data analysis. OBJECTIVES: To identify factors affecting the atlantodental interval (ADI), the Ranawat value, and subaxial translation after rheumatoid arthritis (RA) diagnosis. In addition, factors predictive for Cervical spine instability (CSI) development after RA diagnosis were examined. SUMMARY OF BACKGROUND DATA: Development of CSI affects the prognosis and mortality of RA patients. Previous studies described that obesity is associated with reduced radiographic joint damage in RA patients...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27770823/body-mass-index-and-extent-of-mri-detected-inflammation-opposite-effects-in-rheumatoid-arthritis-versus-other-arthritides-and-asymptomatic-persons
#15
Lukas Mangnus, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Tom W J Huizinga, Monique Reijnierse, Annette H M van der Helm-van Mil
BACKGROUND: In the population a high body mass index (BMI) has been associated with slightly increased inflammatory markers. Within rheumatoid arthritis (RA), however, a high BMI has been associated with less radiographic progression; this phenomenon is unexplained. We hypothesized that the phenomenon is caused by an inverse relationship between BMI and inflammation in hand and foot joints with RA. To explore this hypothesis, local inflammation was measured using magnetic resonance imaging (MRI) in early arthritis patients presenting with RA or other arthritides and in asymptomatic volunteers...
October 22, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27749232/prevalence-of-vitamin-d-deficiency-in-rheumatoid-arthritis-and-association-with-disease-activity-and-cardiovascular-risk-factors-data-from-the-comedra-study
#16
Stella Cecchetti, Zuzana Tatar, Pilar Galan, Bruno Pereira, Céline Lambert, Gael Mouterde, Angela Sutton, Martin Soubrier, Maxime Dougados
OBJECTIVES: The relationship between vitamin D and rheumatoid arthritis (RA) activity remains controversial. RA is a cardiovascular risk factor. A low level of vitamin D may increase blood pressure (BP) and decrease HDL-cholesterol. We aimed to determine the prevalence of vitamin D deficiency in RA patients compared to controls, and also to investigate the relationship between vitamin D and RA activity, and between vitamin D and cardiovascular risk factors. METHODS: Patients in the COMEDRA study with established inactive RA (1987 ACR criteria) were matched with subjects from the NUTRINET-SANTE cohort (age, gender, latitude, sampling season)...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27744324/the-effect-of-obesity-on-survival-in-patients-undergoing-coronary-artery-bypass-graft-surgery-who-receive-a-radial-artery
#17
Umberto Benedetto, Massimo Caputo, Mustafa Zakkar, Alan Davies, Ben Gibbison, Alan Bryan, Gianni D Angelini
OBJECTIVES: The radial artery (RA) is often used as a second arterial conduit in preference to the right internal thoracic artery in obese patients undergoing coronary artery bypass grafting (CABG) to minimise the risk of sternal wound complication. However, obesity has been found to promote RA vasoreactivity and early atherosclerotic degeneration, which may compromise graft patency when used in patients having CABG. Therefore, we investigated the effect of the RA as a second conduit compared with the saphenous vein (SV) on long-term survival in obese and non-obese patients undergoing first-time CABG...
October 15, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27744013/use-of-healthcare-resources-and-costs-associated-to-the-start-of-treatment-with-injectable-drugs-in-patients-with-type-2-diabetes-mellitus
#18
Antoni Sicras-Mainar, Ruth Navarro-Artieda, Raúl Morano, Lucía Ruíz
OBJECTIVES: The main objective was to assess resource use and costs of starting treatment with insulin or injectable GLP-1 receptor analogues (GLP-1 RAs) in a Spanish population of patients with type 2 diabetes mellitus. Treatment adherence and persistence were also determined for both treatment groups. PATIENTS AND METHODS: A retrospective, non-interventional, observational study was conducted. Patients aged ≥20 years who started treatment with insulin or GLP-1 RAs in the 2010-2012 period were recruited...
December 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27736006/body-mass-index-and-response-to-abatacept-in-rheumatoid-arthritis
#19
Anais Gardette, Sébastien Ottaviani, Jérémie Sellam, Francis Berenbaum, Frédéric Lioté, Bruno Fautrel, Elisabeth Palazzo, Alain Meyer, Jean Sibilia, Philippe Dieudé
BACKGROUND: Previous studies suggested that obesity could negatively affect the response to antitumour necrosis factor-α (TNFα) agents in rheumatoid arthritis (RA). However, data are lacking on whether obesity affects the response to abatacept (ABA). We aimed to determine whether body mass index (BMI) affects the response to ABA in RA. MATERIALS AND METHODS: In this multicenter retrospective study, we included RA patients who received ABA. BMI was calculated at the initiation of treatment...
December 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27638812/improvement-in-insulin-resistance-is-greater-when-infliximab-is-added-to-methotrexate-during-intensive-treatment-of-early-rheumatoid-arthritis-results-from-the-idea-study
#20
Lesley-Anne Bissell, Elizabeth M A Hensor, Lukasz Kozera, Sarah L Mackie, Agata N Burska, Jacqueline L Nam, Helen Keen, Edith Villeneuve, Helena Donica, Maya H Buch, Philip G Conaghan, Jacqueline Andrews, Paul Emery, Ann W Morgan
OBJECTIVES: To determine the change in established biomarkers of cardiovascular (CV) risk, namely, total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP) and insulin resistance (IR) in patients with early RA treated with two different treat-to-target strategies. METHODS: Fasting glucose, lipids, insulin and NT-proBNP were measured at baseline, weeks 26 and 78 in 79 DMARD-naïve RA patients, free of CV disease, as part of a double-blind randomized controlled trial of MTX with either infliximab (IFX) or methylprednisolone as induction therapy...
December 2016: Rheumatology
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