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https://www.readbyqxmd.com/read/29121263/high-prevalence-of-diabetes-in-patients-with-rheumatoid-arthritis-results-from-a-questionnaire-survey-linked-to-claims-data
#1
Katinka Albrecht, Andres Luque Ramos, Falk Hoffmann, Imke Redeker, Angela Zink
Objectives: To investigate the prevalence of diabetes in patients with RA and the impact of diabetes on self-reported outcomes and health care. Methods: RA patients between the ages of 18 and 79 years were randomly selected from a nationwide statutory health insurance fund and were surveyed about rheumatological care and disease burden. Comorbid diabetes (E10-14) was analysed regarding age, sex, BMI and socioeconomic status. Disease burden, comorbidity and prescriptions were compared in RA patients with and without diabetes...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29116541/a-cross-sectional-study-of-vitamin-d-levels-in-a-large-cohort-of-patients-with-rheumatic-diseases
#2
Elena Nikiphorou, Jaakko Uksila, Tuulikki Sokka
The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011-April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29106754/right-heart-function-in-impaired-left-ventricular-diastolic-function-2d-speckle-tracking-echocardiography-based-and-doppler-tissue-imaging-based-analysis-of-right-atrial-and-ventricular-function
#3
Anna Brand, Marny Bathe, Sabine Oertelt-Prigione, Ute Seeland, Mirjam Rücke, Vera Regitz-Zagrosek, Karl Stangl, Fabian Knebel, Verena Stangl, Henryk Dreger
AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD). METHODS AND RESULTS: In a cross-sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE...
November 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/29105287/gut-microbiota-interacts-with-markers-of-adipose-tissue-browning-insulin-action-and-plasma-acetate-in-morbid-obesity
#4
José María Moreno-Navarrete, Matteo Serino, Vincent Blasco-Baque, Vincent Azalbert, Richard H Barton, Marina Cardellini, Jèssica Latorre, Francisco Ortega, Mònica Sabater-Masdeu, Rémy Burcelin, Marc-Emmanuel Dumas, Wifredo Ricart, Massimo Federici, José Manuel Fernández-Real
SCOPE: To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota and insulin sensitivity in humans. METHODS AND RESULTS: Gut microbiota composition and gene markers of browning were analysed in subcutaneous (SAT) and visceral (VAT) adipose tissue from morbidly obese subjects (n = 34). Plasma acetate was measured through (1) H NMR and insulin sensitivity using euglycemic hyperinsulinemic clamp. Subjects with insulin resistance showed an increase in the relative abundance (RA) of the phyla Bacteroidetes and Proteobacteria while RA of Firmicutes was decreased...
November 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29104376/anti-tnf-alpha-adalimumab-therapy-had-time-lag-of-improvement-in-synovial-hypertrophy-compared-to-rapid-response-in-power-doppler-synovial-vascularity
#5
Ying-Chou Chen, Chi-Hua Ko, Jia-Feng Chen, Chung-Yuan Hsu, Wen-Chan Chiu, Tien-Tsai Cheng
Objectives: The quantification of synovitis is of great significance for follow-up in patients with rheumatoid arthritis (RA). This study aimed to validate the use of power Doppler ultrasonography (PDUS) for evaluating synovial vascularity and synovial hypertrophy for synovitis in patients with rheumatoid arthritis treated with adalimumab. Materials and Methods: The synovial disease activity and vascularity of RA on both wrists (radio-carpal joint) were assessed using GS and PDUS to derive the composite US scores based on abnormal counts and severity...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29075504/recipients-and-providers-perspectives-of-obesity-and-potential-barriers-to-weight-management-programmes-in-patients-with-rheumatoid-arthritis-ra-a-qualitative-study
#6
G Colligan, J Galloway, H Lempp
BACKGROUND: The UK rheumatology community serves an ageing and ethnically diverse population, with a growing public health concern about obesity. Overweight and obesity contribute to 2.8 million preventable deaths annually. A raised Body Mass Index (BMI) in those with Rheumatoid Arthritis (RA) can have a significant negative impact on clinical outcomes. The aim of the study was to examine patients' and providers' perceptions of obesity and potential barriers to participation in a future weight management programme to contribute to an appropriate intervention design...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29046962/comparison-of-posterior-retroperitoneal-and-transabdominal-lateral-approaches-in-robotic-adrenalectomy-an-analysis-of-200-cases
#7
Bora Kahramangil, Eren Berber
BACKGROUND: Although numerous studies have been published on robotic adrenalectomy (RA) in the literature, none has done a comparison of posterior retroperitoneal (PR) and transabdominal lateral (TL) approaches. The aim of this study was to compare the outcomes of robotic PR and TL adrenalectomy. METHODS: This is a retrospective analysis of a prospectively maintained database. Between September 2008 and January 2017, perioperative outcomes of patients undergoing RA through PR and TL approaches were recorded into an IRB-approved database...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29029250/actigraphy-derived-daily-rest-activity-patterns-and-body-mass-index-in-community-dwelling-adults
#8
Elizabeth M Cespedes Feliciano, Mirja Quante, Jia Weng, Jonathan A Mitchell, Peter James, Catherine R Marinac, Sara Mariani, Susan Redline, Jacqueline Kerr, Suneeta Godbole, Alicia Manteiga, Daniel Wang, J Aaron Hipp
Study Objectives: To examine associations between 24-hour rest-activity patterns and body mass index (BMI) among community-dwelling U.S. adults. Rest-activity patterns provide a field method to study exposures related to circadian rhythms. Methods: Adults (N=578) wore an actigraph on their non-dominant wrist for 7 days. Intradaily variability and interdaily stability, M10 (most active 10-hours), L5 (least active 5-hours) and relative amplitude (RA) were derived using non-parametric rhythm analysis...
October 4, 2017: Sleep
https://www.readbyqxmd.com/read/29016785/obstructive-sleep-apnea-is-associated-with-increased-rotor-burden-in-patients-undergoing-focal-impulse-and-rotor-modification-guided-atrial-fibrillation-ablation
#9
Daniel J Friedman, Peter Liu, Adam S Barnett, Kristen Bova Campbell, Kevin P Jackson, Tristram D Bahnson, James P Daubert, Jonathan P Piccini
Aims: To assess whether obstructive sleep apnea (OSA) was associated with increased rotor burden among atrial fibrillation (AF) patients. Methods and results: We studied 33 consecutive patients who were scheduled for focal impulse and rotor modulation (FIRM) ablation at our institution to describe the mapping, ablation, and outcomes, among patients with and without OSA. Patients underwent biatrial FIRM mapping in AF with ablation of stable rotors in addition to conventional ablation lesion sets...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28993870/serum-serotonin-levels-and-bone-in-rheumatoid-arthritis-patients
#10
Miguel Bernardes, Tiago Vieira, Raquel Lucas, Jorge Pereira, Lúcia Costa, Francisco Simões-Ventura, Maria João Martins
In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample of 205 RA patients and related these to anthropometric variables, disease parameters, serum bone biomarkers, and bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry at several sites (total proximal femur, lumbar spine, left hand, and left second proximal phalange)...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28973022/the-impact-of-cardiovascular-risk-factors-on-cardiac-structure-and-function-insights-from-the-uk-biobank-imaging-enhancement-study
#11
Steffen E Petersen, Mihir M Sanghvi, Nay Aung, Jackie A Cooper, José Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M Lee, Valentina Carapella, Young Jin Kim, Stefan K Piechnik, Stefan Neubauer
AIMS: The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular disease. METHODS: Age, sex, ethnicity (non-modifiable) and systolic blood pressure, diastolic blood pressure, smoking status, exercise, body mass index (BMI), high cholesterol, diabetes, alcohol intake (modifiable) were considered important cardiovascular risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28947312/influence-of-obesity-age-and-comorbidities-on-the-multi-biomarker-disease-activity-test-in-rheumatoid-arthritis
#12
Jeffrey R Curtis, Jeffrey D Greenberg, Leslie R Harrold, Joel M Kremer, J Lynn Palmer
INTRODUCTION: Traditional markers of inflammation are often required for inclusion in rheumatoid arthritis trials, yet patients with active disease may have normal lab tests. The potential use of the multi-biomarker disease activity (MBDA) test in this setting is unclear, as is understanding of whether it is influenced by patient characteristics (e.g., age, BMI, and comorbidities). METHODS: Using data from the Corrona registry, we conducted a cross-sectional analysis of RA patients with MBDA tests...
August 2, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28938465/serum-insulin-bioassay-reflects-insulin-sensitivity-and-requirements-in-type-1-diabetes
#13
Joseph A M J L Janssen, Gemma Llauradó, Aimee J Varewijck, Per-Henrik Groop, Carol Forsblom, Sonia Fernández-Veledo, Elisabeth S R van den Dungen, Joan Vendrell, Leo J Hofland, Hannele Yki-Järvinen
Context: Insulin resistance could increase insulin requirements in type 1 diabetes (T1D). Current insulin immunoassays do not detect insulin analogs. Kinase insulin receptor (IR) activation (KIRA) bioassays specific for human IR isoforms A (IR-A) and B (IR-B) permit assessment of all circulating insulin bioactivity. We studied whether IR-A and IR-B KIRA assays are related to direct measures of insulin sensitivity or insulin doses in T1D. Design: We evaluated 31 adult patients with T1D (age 45...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28916544/muscle-deficits-in-rheumatoid-arthritis-contribute-to-inferior-cortical-bone-structure-and-trabecular-bone-mineral-density
#14
Joshua F Baker, Jin Long, Sogol Mostoufi-Moab, Michele Denburg, Erik Jorgenson, Prerna Sharma, Babette S Zemel, Elena Taratuta, Said Ibrahim, Mary B Leonard
OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. METHODS: Participants, ages 18-75 years, completed whole-body dual-energy x-ray absorptiometry and peripheral quantitative computed tomography (pQCT) of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI), muscle density at the lower leg, trabecular bone density, and cortical bone thickness...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28880707/relationship-between-achievement-of-physical-activity-goal-and-characteristics-of-patients-with-rheumatoid-arthritis
#15
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Shigeki Momohara
OBJECTIVES: We aimed to identify the relationship between achievement of a physical activity goal and the characteristics of patients with rheumatoid arthritis (RA). METHODS: Overall, 137 patients with RA who performed physical activity were enrolled. Statistical analysis was performed to examine relationship between patient characteristics and achievement of physical activity goal by univariate analysis, multivariate logistic regression analysis and the receiver operating characteristic method...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28879052/obesity-is-a-strong-predictor-of-worse-clinical-outcomes-and-treatment-responses-in-early-rheumatoid-arthritis-results-from-the-swefot-trial
#16
Adrian Levitsky, Kerstin Brismar, Ingiäld Hafström, Karen Hambardzumyan, Cecilia Lourdudoss, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVES: The aim of this paper was to analyse the impact of obesity, in addition to known predictors, on disease outcome in early rheumatoid arthritis (RA). METHODS: Body mass index (BMI) was available in 260 patients from the Swedish pharmacotherapy trial (SWEFOT). Differences in disease activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese BMI >30, n=43; overweight BMI=25-29...
2017: RMD Open
https://www.readbyqxmd.com/read/28870033/-the-expression-and-clinical-significance-of-proprotein-convertase-subtilisin-kexin-9-in-rheumatoid-arthritis
#17
Q Du, X J Yu, H J Li, S Q Guan, Z Y Zhang, Y F Mei
Objective: To assess the expression and significance of proprotein convertase subtilisin kexin 9 (PCSK9) in patients with rheumatoid arthritis (RA). Methods: Sixty-five RA patients and forty-seven healthy controls were recruited in this study. The body mass index (BMI) and serum total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), lipoprotein a, low density lipoprotein(LDL), very low density lipoprotein(VLDL), apolipoprotein A(ApoA), apolipoprotein B(ApoB) and the ratio of LDL-C/HDL-C were tested...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#18
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28834907/prevalence-of-type-2-diabetes-and-impaired-fasting-glucose-in-patients-affected-by-rheumatoid-arthritis-results-from-a-cross-sectional-study
#19
Piero Ruscitti, Francesco Ursini, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Francesco Carubbi, Giuliana Guggino, Onorina Berardicurti, Rosadaniela Grembiale, Giovanni Triolo, Giovambattista De Sarro, Roberto Giacomelli
Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28822046/body-mass-index-and-clinical-response-to-intravenous-or-subcutaneous-abatacept-in-patients-with-rheumatoid-arthritis
#20
Maria-Antonietta D'Agostino, Rieke Alten, Eduardo Mysler, Manuela Le Bars, June Ye, Bindu Murthy, Julia Heitzmann, Radu Vadanici, Gianfranco Ferraccioli
This post hoc analysis of ACQUIRE (NCT00559585) explored the effect of baseline body mass index (BMI) on the pharmacokinetics of and clinical response to subcutaneous (SC) or intravenous (IV) abatacept in patients with rheumatoid arthritis (RA). ACQUIRE was a phase 3b, 6-month, double-blind, double-dummy study in which patients with RA were randomized (1:1) to SC (fixed - dose; 125 mg/week) or IV (weight-tiered; ~ 10 mg/kg/month) abatacept plus methotrexate. In this analysis, minimum abatacept plasma concentration (Cmin) was measured at 3 and 6 months, and clinical remission over 6 months was assessed by Disease Activity Score 28 (C-reactive protein; DAS28 [CRP], < 2...
August 18, 2017: Clinical Rheumatology
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