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M Flisinski, E Wisniewska-Chudy, A Brymora, A Stefanska, P Strozecki, J Manitius
Hipoxia inducible factor-1 and HIF-2 are responsible for the adaptation of cell metabolism to hypoxia. Previously, a more severe capillary rarefaction was found in locomotor than in postural muscles of uremic animals. The aim of this study was to analyze the expression patterns of HIF and prolyl hydroxylases (PHDs) in functionally different skeletal muscles in uremic rats, an experimental model of chronic kidney disease (CKD). Rats were randomized to sham operation - CON, uninephrectomy - CKD1/2 or subtotal nephrectomy - CKD5/6...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Gozdem Kayki, Davut Bozkaya, Melek Buyukeren, Betul Tavil, Sule Yigit
Normoblasts may be seen in peripheral blood smear of newborns. The number of normoblasts per 100 white blood cells is generally in the range of 0-10.They can be seen more common than usual in hypoxic condition, because intrauterine hypoxia increases the production of red blood cells. However, multinucleated normoblasts in a newborn caused by hypoxia haven't been reported before. We present a newborn with multinucleated normoblasts secondary to intrauterine hypoxia. This case is important; because it is the first time multinucleated normoblasts in peripheral blood smear of a hypoxic newborn has been detected...
August 1, 2017: Archivos Argentinos de Pediatría
Petronio Generoso Thomaz, Leonel Adelino Moura, Giovana Muramoto, Renato Samy Assad
The clinical definition of cardiogenic shock is that of a low cardiac output and evidence of tissue hypoxia in the presence of adequate blood volume. Cardiogenic shock is the main cause of death related to acute myocardial infarction (AMI), with a mortality rate of 45-70% in the absence of aggressive and highly specialized technical care. The intra-aortic balloon pump (IABP) is one of the most widely used mechanical assisting devices. During the last two decades, about 42% of patients with AMI who evolved with cardiogenic shock received mechanical circulatory assistance with IABP...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
Guilherme Silva Julian, Renato Watanabe de Oliveira, Sergio Tufik, Jair Ribeiro Chagas
Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk. Quantitative real-time PCR is frequently employed to assess changes in gene expression in experimental models. In this study, we analyzed the effects of chronic intermittent hypoxia (an experimental model of OSA) on housekeeping gene expression in the left cardiac ventricle of rats. Analyses via four different approaches-use of the geNorm, BestKeeper, and NormFinder algorithms; and 2-ΔCt (threshold cycle) data analysis-produced similar results: all genes were found to be suitable for use, glyceraldehyde-3-phosphate dehydrogenase and 18S being classified as the most and the least stable, respectively...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Andrea Catalina Trompetero González, Edgar Cristancho Mejía, William Fernando Benavides Pinzón, Mauricio Serrato Roa, María Paula Landinez Macias, Joel Rojas
INTRODUCTION: the development of this research is base on the growing interest in understanding the adaptations to chronic hipoxia mainly in the range of intermediate altitudes (1 500-3 000 m.s.n.m) and the need to establish parameters of normality in the variables [Hb], Hct and SO2 for diagnostic and characterization of the population purposes. OBJECTIVE: to analyze the behavior of the [Hb], Hct and SaO2 at different intermediate altitudes (970 m.s.n.m, 1 520 m...
November 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Mustafa Guven, Tarik Akman, Ali Umit Yener, Muserref Hilal Sehitoglu, Yasemin Yuksel, Murat Cosar
OBJECTIVE: The main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of kefir on spinal cord ischemia injury in rats. METHODS: Rats were divided into three groups : 1) sham operated control rats; 2) spinal cord ischemia group fed on a standard diet without kefir pretreatment; and 3) spinal cord ischemia group fed on a standard diet plus kefir. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model...
May 2015: Journal of Korean Neurosurgical Society
Luis Torres-Ramírez, Jorge Ramírez-Quiñones, Miriam Vélez-Rojas, Martha Flores-Mendoza
Chorea is a movement disorder which is rarely caused by erythrocytosis. Erithrocytosis or polycythemia is the augmentation of the absolute erythrocytic mass and its most common primary cause is polycythemia vera. Some of the secondary causes are erythrocytosis by central hipoxia occurring in people who live in the highlands. Chore is a rare neurological manifestation of erythrocytosis occurring in 0.5 to 2% of these patients. There was a report of a 71 year-old male patient with generalized chorea of sudden onset predominant in mouth, tongue and face and lower limbs, secondary to acquired erythrocytosis, which improved after the number of erythrocytes decreased through successive sessions of phlebotomy...
October 2013: Revista Peruana de Medicina Experimental y Salud Pública
L Ratiani, G Parkosadze, M Cheishvili, G Ormotsadze, M Sulakvelidze, T Sanikidze
The aim of our study was to determine the influence of estrogen on the intensity of oxidative metabolism in women of reproductive and menopausal age. Two groups of women - less than 45 years old (reproductive age) and more than 45 years old (menopausal age) were investigated. In each group we investigated the estradiole, fibrinogen, ALT, oxygen (O(2)(-)) and lipid (LOO·) reactive spesies, NO content, antioxidant enzymes (SOD, catalase, GR) activity. It was reviealed nondirect corelation between development of inflammation, hypoxia and estrogen content in the blood of women without genetic predisponce to alterations of lipid metabolism...
February 2012: Georgian Medical News
Mary Carmen Pérez-Aguilar, Loredana Goncalves, Alba Ibarra, Rafael Bonfante-Cabarcas
Adenosine deaminase (ADA) is an enzyme of purine metabolism which has been the subject of much interest because the congenital defect of this enzyme causes severe combined immunodeficiency syndrome. One of the three isoforms of the enzyme (ecto-ADA) is capable of binding to the glycoprotein CD26 and adenosine receptors A1 and A2B. ADA-CD26 interaction produces a costimulatory signal in the events of T cell activation and secretion of IFN-gamma, TNF-alpha and IL-6. During this activation, the enzyme activity is regulated positively by IL-2 and IL-12 and negatively by IL-4, based on the mechanism of translocation...
December 2010: Investigación Clínica
Miguel S Guerra, Roberto Roncon-Albuquerque, André P Lourenço, Inês Falcão-Pires, Paulo Cibrão-Coutinho, Adelino F Leite-Moreira
The aim of the present study was to investigate how early the onset of ischaemia-induced changes in gene expression is in remote myocardium, and whether these changes would be different for left and right ventricles. Wistar rats (n=27) were randomly assigned to left coronary artery (LCA) ligation for 30 or 120 min and sham groups. Evans Blue infusion revealed antero-apical left ventricle (LV) and left intraventricular (IV) septal ischaemia (35.5+/-0.6% of LV mass). LCA ligation induced transient LV systolic dysfunction and sustained biventricular slowing of relaxation...
March 2006: Experimental Physiology
Li-fang Fan, Lu-ming Diao, De-ji Chen, Ming-qiu Liu, Li-qin Zhu, Hong-gang Li, Zhi-jiao Tang, Dong Xia, Xuan Liu, Hong-lei Chen
BACKGROUND & OBJECTIVES: Hipoxia-inducible factor-1 is a transcriptive factor that regulates genes involved in metabolism, angiogenesis, proliferation, and apoptosis. This study was designed to investigate the expression of hypoxia inducible facter-1 alpha(HIF-1 alpha) and its relationship to bcl-2, Bax, PCNA in lung cancer. METHOD: Immunohistochemical streptavidin/peroxidase(SP) was used to examine the expression of HIF-1a, bcl-2, Bax, and PCNA in 60 cases of lung cancer...
March 2002: Ai Zheng, Aizheng, Chinese Journal of Cancer
A J de Arruda, T R García
This is a descriptive study carried out at a public hospital in the city of João Pessoa--PB, with the objective of establishing a profile of nursing diagnoses related to the component oxygenation in trauma victims. Roy's Theory on physiologic mode of adaptation was used as theoretical reference. The study population was composed of trauma victims admitted to the Intensive Care Unit, after initial assistance in the emergency unit of the hospital. For sample organization, a "time setting" framework was determined during which time data from twenty-two patients was collected...
July 2000: Revista Brasileira de Enfermagem
P de Castro de Castro, I Pascual-Castroviejo
A study of mental development of 108 patients with craniosynostosis is performed. A serious mental retardation was evident in the majority of patients with "clover leaf" and in those with acrocephalosyndactily types Appert and Chotzen, and also when they had trigonocephaly. Oxicephaly, Crouzon's disease, plagiocephaly and Carpenter's and Pfeiffer's diseases show usually a moderate and/or middle retardation. Scaphocephaly has a mental evolution with a normal I.Q., but probability for presenting perinatal hipoxia because the size and aspect of the head is high...
November 1981: Anales Españoles de Pediatría
J A González-Hermosillo, E Lupi, M Cárdenas, J Vidal, D Huerta, E Olvera, L Hurtado
The role of hipoxia on A-V conduction was studied in the patients with severe respiratory insufficiency. Intervals of A-V conduction were measured under basal conditions, breathing room air and with increasing atrial rates. Results are compared with those obtained after the administration of 99% oxygen. A-V conduction times were normal in all the patients while breathing room air and in response to atrial pacing. With oxygen administration most patients had a decrease in A-V conduction at the expense of a prolonged A-H time, without significant alteration of the other time intervals...
March 1978: Archivos del Instituto de Cardiología de México
J Simón, S Mendizábal, I Zamora, F Escrivá
A long-term follow-up study of 27 survivors of acute renal failure in newborns was performed. A study of the evolution of renal function was possible in 20 cases, with follow-up periods ranging from 15 to 62 months (mean follow-up: 38 months). Renal function was determined by assessing glomerular filtration rate, free-water reabsorption, tubular reabsorption of phosphate and acidification ability. Results show a marked difference, according to the etiology of the acuete renal failure, between the two groups studied: 1) Most of those displaying renal failure following neonatal hipoxia, maintained persistent nephrological sequels...
October 1979: Anales Españoles de Pediatría
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