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https://www.readbyqxmd.com/read/29039894/ureteral-orifice-involvement-by-urothelial-carcinoma-long-term-oncologic-and-functional-outcomes
#1
Muammer Altok, Ali F Sahin, Mehmet I Gokce, Gokhan R Ekin, Rauf Taner Divrik
PURPOSE: Bladder cancer (BC) may involve the ureteral orifice, and the resection of the orifice has oncological and functional consequences such as development of upper tract urothelial carcinoma (UTUC), vesicoureteral reflux or ureteral stenosis. The aim of this study was to investigate the oncological and functional outcomes of the ureteral orifice resection in BC patients and determine the predictive factors for UTUC development. MATERIALS AND METHODS: A total of 1359 patients diagnosed with BC, between 1992 and 2012, were reviewed retrospectively...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29037861/biologic-behavior-and-long-term-outcomes-of-carcinoma-in-situ-in-upper-urinary-tract-managed-by-radical-nephroureterectomy
#2
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29032580/impact-of-ureteroscopy-before-radical-nephroureterectomy-for-upper-tract-urothelial-carcinomas-on-oncologic-outcomes-a-meta-analysis
#3
Run-Qi Guo, Peng Hong, Geng-Yan Xiong, Zhang Lei, Dong Fang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
OBJECTIVES: To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUC) has an impact on oncologic outcomes. MATERIALS AND METHODS: We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described URS performed on patients with UTUC and conducted a standard meta-analysis on survival outcomes. RESULTS: Our meta-analysis included eight eligible studies containing 3,975 patients...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032451/impact-of-body-mass-index-on-the-oncological-outcomes-of-patients-treated-with-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#4
Yohann Dabi, Mohammed El Mrini, Igor Duquesnes, Nicolas Barry Delongchamps, Mathilde Sibony, Marc Zerbib, Evanguelos Xylinas
PURPOSE: To evaluate the association between body mass index (BMI) and oncological outcomes in patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). METHODS: We retrospectively reviewed 237 consecutive patients treated with RNU for UTUC at our institution between 1990 and 2012. Univariable and multivariable cox regression models investigated the association of BMI with disease recurrence, cancer-specific mortality, and overall mortality...
October 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29031419/impact-of-surgical-waiting-time-on-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-national-cancer-database-study
#5
Leilei Xia, Benjamin L Taylor, Jose E Pulido, Thomas J Guzzo
PURPOSE: To evaluate the impact of surgical waiting time (SWT) on the survival outcome in patients with upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We identified patients with nonmetastatic UTUC who underwent radical nephroureterectomy (RNU) between 2004 and 2013 in the National Cancer Database. The association between SWT and overall survival (OS) was evaluated using Cox proportional hazards regression. SWT was categorized into 6 groups: SWT ≤ 7 days, SWT 8 to 30 days, SWT 31 to 60 days, SWT 61 to 90 days, SWT 91 to 120 days, and SWT 121 to 180 days...
October 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29029534/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#6
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029487/prognostic-factors-and-outcomes-of-primary-transitional-cell-carcinoma-of-the-ureter-a-population-based-study
#7
Tao Ding, Zhuojun Zheng, Renfang Xu, Cuixing Zhou
OBJECTIVE: This study investigated the prognostic factors and outcomes of a large observational cohort of patients with primary transitional cell carcinoma of the ureter, which was obtained from the Surveillance, Epidemiology, and End Results database. METHODS: We used the Surveillance, Epidemiology, and End Results program to identify 1910 patients who had available clinical and follow-up information and were diagnosed for primary transitional cell carcinoma of the ureter between 2004 and 2013...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28994829/bladder-cancer-benefit-of-adjuvant-chemotherapy-in-utuc-unclear
#8
Clemens Thoma
No abstract text is available yet for this article.
October 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28978171/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#9
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28972702/survival-outcomes-for-patients-with-localized-upper-tract-urothelial-carcinoma-managed-with-non-definitive-treatment
#10
Jamil S Syed, Kevin A Nguyen, Alfredo Suarez-Sarmiento, Katelyn Johnson, Michael S Leapman, Jay D Raman, Brian Shuch
OBJECTIVE: To investigate the outcomes of patients with upper tract urothelial carcinoma (UTUC) with non-definitive therapy, which currently remains unknown. SUBJECTS/PATIENTS AND METHODS: We utilized the Surveillance, Epidemiology, and End Results (SEER) database to identify individuals with a localized, histologically confirmed kidney/renal pelvis and ureteral urothelial carcinoma. Survival analysis using the Kaplan Meier method was performed. A competing risk model evaluated the cumulative incidence and predictors of cancer specific mortality (CSM)...
October 3, 2017: BJU International
https://www.readbyqxmd.com/read/28967037/loss-of-stromal-antigen-2-stag2-expression-in-upper-urinary-tract-carcinoma-differential-prognostic-effect-according-to-the-ki-67-proliferating-index
#11
Jimpei Miyakawa, Teppei Morikawa, Yu Miyama, Tohru Nakagawa, Taketo Kawai, Yukio Homma, Masashi Fukayama
BACKGROUND: Inactivating mutation and consequent expression loss of stromal antigen 2 (STAG2, also known as SA2), a component of the cohesion complex, is one of the most common genetic aberrations in urothelial carcinoma. However, the clinicopathologic or prognostic significance of STAG2 alterations in upper tract urothelial carcinoma (UTUC) is largely unknown. METHODS: This study immunohistochemically examined the expression of STAG2 in 171 patients with UTUC. The correlations of STAG2 loss with clinicopathologic features and patients' prognoses were examined...
October 2, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28940605/adjuvant-chemotherapy-after-radical-nephroureterectomy-does-not-improve-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-joint-study-by-the-european-association-of-urology-young-academic-urologists-and-the%C3%A2-upper-tract-urothelial-carcinoma-collaboration
#12
Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Marco Moschini, Kees Hendricksen, Michael Rink, Roman Sosnowski, Jakub Dobruch, Jay D Raman, Christopher G Wood, Vitaly Margulis, Morgan Roupret, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort of patients with upper tract urothelial carcinoma (UTUC) in order to clarify whether such patients benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU). PATIENTS AND METHODS: Data from 15 centres were collected for a total of 1544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2-4N0/x stage, or lymph node-positive disease, and prior RNU...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28881664/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#13
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, Ana Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28867446/european-association-of-urology-guidelines-on-upper-urinary-tract-urothelial-carcinoma-2017-update
#14
Morgan Rouprêt, Marko Babjuk, Eva Compérat, Richard Zigeuner, Richard J Sylvester, Maximilian Burger, Nigel C Cowan, Paolo Gontero, Bas W G Van Rhijn, A Hugh Mostafid, Joan Palou, Shahrokh F Shariat
CONTEXT: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice. OBJECTIVE: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians. EVIDENCE ACQUISITION: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline...
September 1, 2017: European Urology
https://www.readbyqxmd.com/read/28864222/upper-tract-urothelial-carcinomas-prognostic-factors-and-outcomes-in-patients-with-non-lymph-node-distant-metastasis
#15
Elena Sevillano, Lillian Werner, Dominick Bossé, Aly-Khan A Lalani, Stephanie A M Wankowicz, Guillermo de Velasco, Matthew Farina, Kevin Lundgren, Toni K Choueiri, Aranzazu González Del Alba, Joaquim Bellmunt
BACKGROUND: Upper tract urothelial carcinomas (UTUCs) are increasingly recognized as separate malignancies. Additional insight into clinical outcomes and key prognostic factors are needed. OBJECTIVES: To detail outcomes of patients with UTUCs recurring after radical nephroureterectomy (RNU) and to determine a risk score that predicts outcomes of patients with non-lymph node distant metastasis. DESIGN, SETTING, AND PARTICIPANTS: Chart review of all patients who had an extraurothelial recurrence after RNU for UTUC at Dana-Farber Cancer Institute between 2009 and 2014...
August 2, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28853106/prognostic-role-of-lymphovascular-invasion-in-patients-with-urothelial-carcinoma-of-the-upper-urinary-tract
#16
Manel Mellouli, Slim Charfi, Walid Smaoui, Rim Kallel, Abdelmajid Khabir, Mehdi Bouacida, Mohamed Nabil Mhiri, Tahya Sellami Boudawara
PURPOSE: To evaluate the impact of lymphovascular invasion on the prognosis of patients treated for upper urinary tract urothelial carcinomas. MATERIALS AND METHODS: Clinical records of 49 patients treated surgically at our institute for upper urinary tract urothelial carcinomas were reviewed retrospectively. LVI was defined as the presence of cancer cells within an endotheluim-lined space without underlying muscular walls. Actuarial survival curves were analysed by Kaplan-Meier method...
August 29, 2017: Urology Journal
https://www.readbyqxmd.com/read/28836549/validation-of-the-pretreatment-neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-in-a-large-cohort-of-chinese-patients-with-upper-tract-urothelial-carcinoma
#17
Zhen-Peng Cao, Bao Guan, Guang-Zhi Zhao, Dong Fang, Geng-Yan Xiong, Xue-Song Li, Li-Qun Zhou
BACKGROUND: The pretreatment neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor in various types of carcinomas. The aim of this study was to investigate the prognostic value of pretreatment NLR in a large cohort of Chinese patients with upper tract urothelial carcinoma (UTUC). METHODS: We retrospectively analyzed the medical data of 656 UTUC patients who underwent radical nephroureterectomy (RNU) from 2001 to 2011 at Peking University First Hospital...
September 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28829370/mir-30a-5p-inhibits-epithelial-to-mesenchymal-transition-and-upregulates-expression-of-tight-junction-protein-claudin-5-in-human-upper-tract-urothelial-carcinoma-cells
#18
Yueh-Hua Chung, Sung-Chou Li, Ying-Hsien Kao, Hao-Lun Luo, Yuan-Tso Cheng, Pey-Ru Lin, Ming-Hong Tai, Po-Hui Chiang
The involvement of microRNAs (miRNAs) in cancer development and their potential as prognostic biomarkers are becoming increasingly known. However, the signature of miRNAs and their regulatory roles in tumorigenesis of upper tract urothelial carcinoma (UTUC) remain to be elucidated. This study aimed to profile the miRNA expression pattern in UTUC tumor tissues and identify candidate miRNAs with prognostic and/or therapeutic functions. METHODS AND RESULTS: We collected 22 UTUC tissue and adjacent normal tissues samples from patients who underwent nephroureterectomy...
August 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28826702/preoperative-prognostic-nutritional-index-is-a-significant-predictor-of-survival-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#19
Jiwei Huang, Yichu Yuan, Yanqing Wang, YongHui Chen, Wen Kong, Wei Xue, Haige Chen, Jin Zhang, Yiran Huang
BACKGROUND: Patient's nutritional and immunological status have a potentially significant role in survival outcome in patients with malignant tumors. We investigated the prognostic value of preoperative prognostic nutritional index (PNI) in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephrouretectomy (RNU). PATIENTS AND METHODS: A total of 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent RNU were evaluated. PNI was calculated as 10 × serum albumin concentration (g/dl) + 0...
August 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28818526/which-patients-with-upper-tract-urothelial-carcinoma-can-be-safely-treated-with-conservative-treatment-by-flexible-ureteroscopy-with-holmium-yag-laser-photoablation-long-term-results-from-a-high-volume-institution
#20
Luca Villa, Mattieu Haddad, Umberto Capitanio, Bhaskar K Somani, Jonathan Cloutier, Steeve Doizi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Olivier Traxer
PURPOSE: We tested the effects of tumor size, distribution and grade on progression-free survival in patients with upper tract urothelial carcinoma treated with flexible ureteroscopy with Ho:YAG laser photoablation. MATERIALS AND METHODS: Included in analysis were data on 92 consecutive patients with upper tract urothelial carcinoma treated with Ho:YAG laser photoablation from 2003 to 2015 at a single tertiary care referral center. Stringent followup was offered according to EAU (European Association of Urology) guidelines...
August 15, 2017: Journal of Urology
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