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https://www.readbyqxmd.com/read/27910890/adjuvant-radiotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma
#1
Yun-Ching Huang, Ying-Hsu Chang, Kuo-Hsiung Chiu, Alan W Shindel, Chia-Hsuan Lai
There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively reviewed 198 patients treated with RNU between December 2001 and January 2015. Postoperative radiotherapy was administered in 40 (20.2%) of patients. Patients who received radiotherapy were younger than those that did not (65...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906675/preoperative-serum-pre-albumin-as-an-independent-prognostic-indicator-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#2
Jiwei Huang, Yanqing Wang, Yichu Yuan, Yong-Hui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang
PURPOSE: To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy. METHODS AND MATERIALS: Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level was defined as <20 mg/dl, while hypoalbuminemia was defined as albumin <35 g/L...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901490/prognostic-value-of-preoperative-plasma-fibrinogen-level-and-platelet-to-lymphocyte-ratio-f-plr-in-patients-with-localized-upper-tract-urothelial-carcinoma
#3
Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang
PURPOSE: Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887951/a-multi-institutional-comparison-of-clinicopathologic-characteristics-and-oncologic-outcomes-of-upper-tract-urothelial-carcinoma-in-china-and-the-united-states
#4
Nirmish Singla, Dong Fang, Xiaohong Su, Zhengqing Bao, Zhenpeng Cao, Syed M Jafri, Gengyan Xiong, Lei Zhang, Ryan Hutchinson, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Liqun Zhou, Jay D Raman, Vitaly Margulis
PURPOSE: To evaluate differences in clinicopathologic characteristics and oncologic outcomes between upper-tract urothelial carcinoma (UTUC) patients in China and the United States (U.S.). METHODS: Clinicopathologic and oncologic outcomes data of UTUC patients treated surgically at tertiary care medical facilities in the U.S. or China from 1998-2015 were retrospectively compiled. Baseline demographics, comorbidities, and pathologic features were evaluated. Oncologic endpoints including intravesical recurrence and cancer-specific survival (CSS) were obtained following exclusion of patients who received systemic chemotherapy...
November 22, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27885451/increased-nucleophosmin-expression-is-a-strong-predictor-of-recurrence-and-prognosis-in-patients-with-n0m0-upper-tract-urothelial-carcinoma-undergoing-radical-nephroureterectomy
#5
Harutake Sawazaki, Keiichi Ito, Takako Asano, Kenji Kuroda, Akinori Sato, Junichi Asakuma, Akio Horiguchi, Kenji Seguchi, Tomohiko Asano
PURPOSE: We aimed to evaluate whether increased nucleophosmin expression predicts recurrence and survival in upper tract urothelial carcinoma (UTUC). METHODS: Specimens from 101 patients with N0M0 UTUC undergoing radical nephroureterectomy were evaluated. Nucleophosmin expression was determined immunohistochemically and categorized into two groups according to nucleophosmin staining intensity. The association between nucleophosmin expression and various clinicopathological factors including Ki-67 expression was analyzed...
November 24, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27870887/epidermal-growth-factor-receptor-and-ki-67-as-predictive-biomarkers-identify-patients-who-will-be-more-sensitive-to-intravesical-instillations-for-the-prevention-of-bladder-cancer-recurrence-after-radical-nephroureterectomy
#6
Xingbo Long, Xiongbing Zu, Yuan Li, Wei He, Xiheng Hu, Shiyu Tong, Zhi Wang, Minfeng Chen, Lin Qi
BACKGROUND: To date, prophylactic intravesical chemotherapy after radical nephroureterectomy is one of the few available treatments that effectively prevent secondary bladder cancer. However, treating all patients with prophylactic intravesical chemotherapy is excessive for patients who are at a low risk or insensitive to the treatment. Thus, to guide individualized clinical treatment, in addition to identifying patients who are at risk of bladder cancer recurrence, it is equally necessary to identify the patients who will benefit the most from prophylactic, postoperative intravesical instillation therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27846934/-ccafu-french-national-guidelines-2016-2018-on-upper-tract-tumors
#7
M Rouprêt, P Colin, E Xylinas, E Compérat, F Dubosq, N Houédé, S Larré, A Masson-Lecomte, Y Neuzillet, G Pignot, P Puech, M Roumiguié, A Méjean
INTRODUCTION: The purpose was to propose an update of the french guidelines from the national committee CCAFU on upper tract urothelial carcinomas (UTUC). METHODS: A systematic Medline search was performed between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of UTUC, to evaluate different references with levels of evidence. RESULTS: The diagnosis of this rare pathology is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27830374/prognostic-role-of-expression-of-n-cadherin-in-patients-with-upper-tract-urothelial-carcinoma-a-multi-institutional-study
#8
Mohammad Abufaraj, Marco Moschini, Francesco Soria, Kilian Gust, Mehmet Özsoy, Romain Mathieu, Morgan Rouprêt, Vitaly Margulis, Jose A Karam, Christopher G Wood, Alberto Briganti, Karim Bensalah, Andrea Haitel, Shahrokh F Shariat
PURPOSE: To assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients. PATIENTS AND METHODS: Immunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The Kaplan-Meier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27785917/risk-of-intravesical-recurrence-after-ureteroscopic-biopsy-for-upper-tract-urothelial-carcinoma-does-the-location-matter
#9
Sangjun Yoo, Dalsan You, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong
INTRODUCTION: To investigate whether ureteroscopic biopsy (URS-Bx) for upper tract urothelial carcinoma (UTUC) before radical nephroureterectomy affects intravesical recurrence (IVR). PATIENTS AND METHODS: Of the 515 patients receiving radical nephroureterectomy for UTUC between 1998 and 2012, 387 patients were included for the analysis. URS-Bx was performed in 69 patients (17.8%). Patients were stratified according to tumor location, and the impact of URS-Bx on IVR was evaluated after adjusting for other clinicopathologic variables...
October 27, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27785429/predictive-models-and-prognostic-factors-for-upper-tract-urothelial-carcinoma-a-comprehensive-review-of-the-literature
#10
REVIEW
Aurélie Mbeutcha, Romain Mathieu, Morgan Rouprêt, Kilian M Gust, Alberto Briganti, Pierre I Karakiewicz, Shahrokh F Shariat
In the context of customized patient care for upper tract urothelial carcinoma (UTUC), decision-making could be facilitated by risk assessment and prediction tools. The aim of this study was to provide a critical overview of existing predictive models and to review emerging promising prognostic factors for UTUC. A literature search of articles published in English from January 2000 to June 2016 was performed using PubMed. Studies on risk group stratification models and predictive tools in UTUC were selected, together with studies on predictive factors and biomarkers associated with advanced-stage UTUC and oncological outcomes after surgery...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785428/risk-stratification-for-kidney-sparing-procedure-in-upper-tract-urothelial-carcinoma
#11
REVIEW
Zine-Eddine Khene, Romain Mathieu, Solène-Florence Kammerer-Jacquet, Thomas Seisen, Morgan Roupret, Shahrokh F Shariat, Benoit Peyronnet, Karim Bensalah
Risk stratification for kidney sparing procedures (KSP) to treat upper tract urothelial carcinoma (UTUC) is a major issue. A non-systematic Medline/PubMed literature search was performed using the terms "upper tract urothelial carcinoma" with different combinations of keywords to review the current knowledge on this topic. Original articles, reviews and editorials in English language were selected based on their clinical relevance. Available techniques for KSP include segmental ureterectomy and endoscopic resection through a percutaneous or flexible ureteroscopic access...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785421/lynch-syndrome-and-exposure-to-aristolochic-acid-in-upper-tract-urothelial-carcinoma-its-clinical-impact
#12
REVIEW
Pierre Colin, Thomas Seisen, Romain Mathieu, Sharohkh F Shariat, Morgan Rouprêt
The purpose of the current review was to describe the clinical risk for Lynch syndrome (LS) after exposure to aristolochic acid (AA) in cases of upper urinary-tract urothelial carcinoma (UTUC). A systematic review of the scientific literature was performed using the Medline database (National Library of Medicine, PubMed) using the following keywords: epidemiology, risk factor, AA, Balkan nephropathy (BNe), LS, hereditary cancer, hereditary non-polyposis colorectal cancer (HNPCC), mismatch repair genes, urothelial carcinomas, upper urinary tract, renal pelvis, ureter, Amsterdam criteria, genetic counselling, mismatch repair genes, genetic instability, microsatellite, and Bethesda guidelines...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785420/why-are-upper-tract-urothelial-carcinoma-two-different-diseases
#13
REVIEW
Tibor Szarvas, Orsolya Módos, András Horváth, Péter Nyirády
In the last few years growing evidence highlighted the differences between upper tract urothelial carcinoma (UTUC) and urothelial bladder carcinoma (UBC) which cannot be explained solely by their different anatomical location. The aim of this review was to summarize current progress in UTUC research and to underline the differences and similarities between UTUC and UBC by focusing on epidemiology, etiology, staging and risk factors as well as on surgical and medical management. UBC and UTUC sharing common risk factors such as smoking and aromatic amines, while aristolochic acid exposure or familiar Lynch syndrome are rather specific for UTUC...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27780919/mcm10-overexpression-implicates-adverse-prognosis-in-urothelial-carcinoma
#14
Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Yu-Ching Wei, Hsin-Chih Yeh, Lin-Li Chang, Chun-Hsiung Huang, Peir-In Liang, Bi-Wen Yeh, Ti-Chun Chan, Chien-Feng Li, Wen-Jeng Wu
Urothelial carcinoma (UC) occurs in the upper urinary tract (UTUC) and the urinary bladder (UBUC). The molecular pathogenesis of UC has not been fully elucidated. Through data mining of a published transcriptome of UBUC (GSE31684), we identified Minichromosome Maintenance Complex Component 2 (MCM2) and MCM10 as the two most significantly upregulated genes in UC progression among the MCM gene family, the key factors for the initiation of DNA replication. To validate the clinical significance of MCM2 and MCM10, immunohistochemistry, evaluated by H-score, was used in a pilot study of 50 UTUC and 50 UBUC samples...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27765584/long-term-bladder-and-upper-urinary-tract-follow-up-recurrence-and-progression-rates-of-g1-2-non-muscle-invasive-urothelial-carcinoma-of-the-bladder
#15
Thomas Golabesk, Joan Palou, Oscar Rodriguez, Ruben Parada, Sergio Skrobot, José Antonio Peña, Humberto Villavicencio
OBJECTIVE: To evaluate the risk of long-term tumour recurrence and progression in patients with low- and intermediate-risk NMIBCs, which could facilitate optimisation in the follow-up schedules. PATIENTS AND METHODS: A single-institution, retrospective analysis of 704 patients with primary TaG1, TaG2, T1G1, and T1G2 urothelial carcinomas of the bladder (UBS) without concomitant carcinoma in situ (CIS), treated with transurethral resection (TUR) was performed. Response was determined and monitored by routine periodic urine cytology, cystoscopy, and upper tract imaging...
October 17, 2016: Urology
https://www.readbyqxmd.com/read/27760608/-clinicopathologic-characteristics-and-prognosis-of-upper-tract-urothelial-carcinoma-an-analysis-of-368-radical-nephroureterectomy-specimens
#16
Y Wang, H Y He
Objective: To evaluate the epidemiology, clinicopathological features and prognosis in upper tract urothelial carcinoma (UTUC) patients. Methods: All archival 368 UTUC cases that underwent radical nephroureterectomy between September 1999 and October 2014 were reviewed, and their clinicopathological features were analyzed. Follow-up time was 1-216 months, with a mean follow-up of 41 month. Results: One hundred and twenty-eight male and 240 female patients were included, with a mean age of 68 years ranging from 31 to 88 years...
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27732981/validation-of-the-preoperative-platelet-to-lymphocyte-ratio-as-a-prognostic-factor-in-a-european-cohort-of-patients-with-upper-tract-urothelial-carcinoma
#17
Orietta Dalpiaz, Daniel Krieger, Georg C Ehrlich, Kristof Pohlmann, Tatjana Stojakovic, Karl Pummer, Richard Zigeuner, Martin Pichler, Georg C Hutterer
INTRODUCTION: This study is aimed at investigating the potential prognostic impact of the preoperatively assessed platelet-to-lymphocyte ratio (PLR) in a European cohort of patients with non-metastatic upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: Clinicopathological data from 180 consecutive non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic center, were evaluated retrospectively. The preoperative PLR was assessed one day before surgery...
October 13, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27730305/androgen-receptor-expression-is-associated-with-adverse-pathological-features-in-ureteral-but-not-in-pelvicalyceal-urothelial-carcinomas-of-the-upper-urinary-tract
#18
G J Wirth, A Haitel, M Moschini, F Soria, T Klatte, M R Hassler, K Bensalah, A Briganti, J A Karam, Y Lotan, V Margulis, J D Raman, M Remzi, N Rioux-Leclercq, B D Robinson, M Rouprêt, C G Wood, S F Shariat
PURPOSE: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). METHODS: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS)...
October 11, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27720772/sustained-release-formulation-of-mitomycin-c-to-the-upper-urinary-tract-using-a-thermosensitive-polymer-a-preclinical-study
#19
Nicholas M Donin, Sandra Duarte, Andrew T Lenis, Randy Caliliw, Cristobal Torres, Anthony Smithson, Dalit Strauss-Ayali, Yael Agmon-Gerstein, Nadav Malchi, Jonathan Said, Steven S Raman, Stuart Holden, Allan Pantuck, Arie S Belldegrun, Karim Chamie
OBJECTIVE: To evaluate the safety and feasibility of single and serial instillations of MitoGel™ into the upper urinary tract using a preclinical swine animal model. MitoGel™ is a novel sustained release formulation of MMC based on RTGel™, a proprietary thermosensitive hydrogel technology. MitoGel™ is liquid at cold temperatures and solidifies to gel state at body temperature. It is intended as a treatment for UTUC given its ability to provide sustained release of MMC in the upper urinary tract...
October 5, 2016: Urology
https://www.readbyqxmd.com/read/27692696/de-ritis-ratio-ast-alt-as-a-significant-prognostic-factor-in-patients-with-upper-tract-urothelial-cancer-treated-with-surgery
#20
Hakmin Lee, Young Hyo Choi, Hyun Hwan Sung, Deok Hyun Han, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi
INTRODUCTION: We investigated the clinical prognostic value of preoperative De Ritis ratio (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]) on postsurgical survival outcomes in patients with upper tract urothelial cancer (UTUC). PATIENTS AND METHODS: We retrospectively analyzed the data of 623 patients who underwent radical nephrouretectomy for UTUC. Multivariate regression tests were performed to identify possible associations between adverse pathologic events and AST/ALT...
September 7, 2016: Clinical Genitourinary Cancer
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