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https://www.readbyqxmd.com/read/29239844/selected-high-risk-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy-for-adjuvant-chemotherapy-a-multi-institutional-retrospective-study
#1
Masaomi Ikeda, Kazumasa Matsumoto, Takahiro Hirayama, Dai Koguchi, Yasukiyo Murakami, Daisuke Matsuda, Norihiko Okuno, Takuji Utsunomiya, Yoshinori Taoka, Akira Irie, Masatsugu Iwamura
BACKGROUND: No definitive evidence exists regarding use of adjuvant chemotherapy (AC) for high-risk cases after radical nephroureterectomy (RNU), and the benefit of AC remains controversial. The aims of this study were to evaluate the efficacy of AC in patients with upper tract urothelial carcinoma (UTUC) and to determine those who qualified for AC. PATIENTS AND METHODS: From 1990 to 2015, 449 patients with nonmetastatic UTUC underwent RNU at 6 Kitasato University-affiliated hospitals...
November 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29224014/diagnostic-ureteroscopy-prior-to-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-increased-the-risk-of-intravesical-recurrence
#2
Ping Tan, Nan Xie, Lu Yang, Liangren Liu, Zhuang Tang, Qiang Wei
OBJECTIVE: To assess the impact of diagnostic ureteroscopy (URS) prior to radical nephroureterectomy (RNU) on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A systematic literature search of the Medline, Embase, PubMed, and Cochrane library was performed in August 2017. Cumulative analyses of available hazard ratios (HRs) and their 95% CI were conducted using Stata version 12.0. RESULTS: Eleven studies including 4,057 participants were included, with a total of 1,403 patients diagnosed with IVR during the follow-up period...
December 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29200949/over-expression-of-activated-signal-transducer-and-activator-of-transcription-3-predicts-poor-prognosis-in-upper-tract-urothelial-carcinoma
#3
Wei-Ming Li, Chun-Nung Huang, Yi-Chen Lee, Szu-Han Chen, Hui-Hui Lin, Wen-Jeng Wu, Ching-Chia Li, Hsin-Chih Yeh, Lin-Li Chang, Wei-Chi Hsu, Hung-Lung Ke
Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29195499/adjuvant-chemotherapy-improves-survival-of-patients-with-high-risk-upper-urinary-tract-urothelial-carcinoma-a-propensity-score-matched-analysis
#4
Kazutoshi Fujita, Kei Taneishi, Teruo Inamoto, Yu Ishizuya, Shingo Takada, Masao Tsujihata, Go Tanigawa, Noriko Minato, Shigeaki Nakazawa, Tsuyoshi Takada, Toshichika Iwanishi, Motohide Uemura, Yasushi Okuno, Haruhito Azuma, Nonomura Norio
BACKGROUND: The purposes of this study were to determine whether adjuvant chemotherapy (AC) improved the prognosis of patients with high-risk upper urinary tract urothelial carcinoma (UTUC)and to identify the patients who benefited from AC. METHODS: Among a multi-center database of 1014 patients who underwent RNU for UTUC, 344 patients with ≥ pT3 or the presence of lymphovascular invasion (LVI) were included. Cancer-specific survival (CSS) estimates were calculated by the Kaplan-Meier method, and groups were compared by the log-rank test...
December 1, 2017: BMC Urology
https://www.readbyqxmd.com/read/29182602/utuc-in-2017-emerging-evidence-on-treating-upper-tract-urothelial-cancer
#5
Pietro Grande, Morgan Rouprêt
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29177431/significance-of-preoperative-butyrylcholinesterase-level-as-an-independent-predictor-of-survival-in-patients-with-upper-urinary-tract-urothelial-carcinoma-treated-with-nephroureterectomy
#6
Daisuke Noro, Takuya Koie, Yasuhiro Hashimoto, Toshikazu Tanaka, Chikara Ohyama, Yuki Tobisawa, Tohru Yoneyama, Atsushi Imai, Shingo Hatakeyama, Hayato Yamamoto, Masato Kitayama, Kazuyoshi Hirota
Objectives: Butyrylcholinesterase (BChE) is an alpha-glycoprotein synthesized in the liver. Its serum levels are reportedly correlated with disease activity in patients with cancer. The aim of this study was to estimate the potential prognostic significance of preoperative serum BChE levels in patients with upper urinary tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). Methods: Of the 220 patients with UTUC who underwent RNU between 1995 and 2016 at Hirosaki University Hospital, 149 patients with available laboratory data were included for analysis...
November 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29174945/preoperative-predictors-of-nonorgan-confined-disease-in-upper-tract-urothelial-carcinoma-differ-between-china-and-the-united-states
#7
Nirmish Singla, Dong Fang, Xiaohong Su, Zhengqing Bao, Zhenpeng Cao, Haley Robyak, Gengyan Xiong, Lei Zhang, Solomon Woldu, Ryan Hutchinson, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Liqun Zhou, Jay D Raman, Vitaly Margulis
OBJECTIVE: To compare preoperative predictors of nonorgan-confined (NOC) disease in patients with upper-tract urothelial carcinoma (UTUC) from the United States (US) and China. METHODS: Clinicopathologic data of patients with UTUC treated surgically at tertiary care facilities in the US or China from 1998 to 2015 were, retrospectively, compiled. Patient characteristics, preoperative imaging, cytology, ureteroscopic findings, and serum markers (neutrophil-to-lymphocyte ratio, estimated glomerular filtration rate, hemoglobin, and albumin) were evaluated...
November 23, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29161613/molecular-characterization-of-urothelial-carcinoma-of-the-bladder-and-upper-urinary-tract
#8
Ji Yun Lee, Kyung Kim, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han-Yong Choi, Ghee-Young Kwon, Kyoung-Mee Kim, Jeeyun Lee, Ho Yeong Lim, Se Hoon Park
PURPOSE: A better understanding of the molecular basis of urothelial carcinoma (UC) is needed to refine the clinical decision-making process. METHODS AND MATERIALS: We performed next-generation sequencing to investigate the mutational and transcriptional profiles of commonly mutated genes in UC using Ampliseq v2. Copy number variations (CNVs) were detected with nCounter assay. Genetic alterations between upper tract UC (UTUC) and urinary bladder UC (UBUC) were compared...
November 18, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29158173/standardized-and-simplified-retroperitoneal-lymph-node-dissection-during-retroperitoneal-laparoscopic-radical-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-ureter-or-renal-pelvis-en-bloc-resection-technique
#9
Toru Kanno, Go Kobori, Masashi Kubota, Satoshi Funada, Takao Haitani, Takashi Okada, Yoshihito Higashi, Seiji Moroi, Hitoshi Yamada
OBJECTIVE To describe our en-bloc technique of retroperitoneal lymph node dissection (RPLND) during retroperitoneal laparoscopic radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC) and evaluate perioperative outcomes. METHODS From 2002 to 2015, 114 patients with UTUC located at the pelvis and/or upper or middle ureter underwent retroperitoneal laparoscopic RNU at two institutions. Performance of RPLND began in February 2009. The template of RPLND included the renal hilar and para-aortic lymph nodes (left side) and the renal hilar, paracaval, retrocaval, and intra-aortocaval lymph nodes (right side)...
November 17, 2017: Urology
https://www.readbyqxmd.com/read/29158169/potential-benefit-of-lymph-node-dissection-during-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-a-systematic-review-by-the-european-association-of-urology-guidelines-panel-on-non-muscle-invasive-bladder-cancer
#10
REVIEW
Jose Luis Dominguez-Escrig, Benoit Peyronnet, Thomas Seisen, Harman M Bruins, Cathy Yuhong Yuan, Marko Babjuk, Andreas Böhle, Maximilian Burger, Eva M Compérat, Paolo Gontero, Thomas Lam, Steven MacLennan, Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Richard J Sylvester, Richard Zigeuner, Shahrokh F Shariat, Morgan Rouprêt
CONTEXT: The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial. OBJECTIVE: To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients. EVIDENCE ACQUISITION: Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND...
November 17, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29158104/impact-of-primary-tumor-location-on-survival-from-eortc-advanced-urothelial-cancer-studies
#11
Marco Moschini, Shahrokh F Shariat, Morgan Rouprêt, Maria De Santis, Joaquim Bellmunt, Cora N Sternberg, Bertrand Tombal, Laurence Collette
OBJECTIVE: The prognostic relevance of primary location of urothelial carcinoma (UC) on survival has been poorly investigated. METHODS: The prospectively collected data from three EORTC advanced UC studies 30924 (M-VAC versus high dose M-VAC), 30986 (MCAVI versus GC arm, among patients unfit for CDDP) and 30987 (GC-Paclitaxel versus GC, among patients fit for CDDP) were used. Patients were grouped by primary tumor location as bladder (BCa) versus upper tract urothelial carcinoma (UTUC)...
November 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154042/oncological-outcomes-of-laparoscopic-nephroureterectomy-versus-open-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-an-european-association-of-urology-guidelines-systematic-review
#12
REVIEW
Benoit Peyronnet, Thomas Seisen, Jose-Luis Dominguez-Escrig, Harman Max Bruins, Cathy Yuhong Yuan, Thomas Lam, Steven Maclennan, James N'dow, Marko Babjuk, Eva Comperat, Richard Zigeuner, Richard J Sylvester, Maximilian Burger, Hugh Mostafid, Bas W G van Rhijn, Paolo Gontero, Joan Palou, Sharokh F Shariat, Morgan Roupret
CONTEXT: Most series have suggested better perioperative outcomes of laparoscopic radical nephroureterectomy (RNU) over open RNU. However, the oncological safety of laparoscopic RNU remains controversial. OBJECTIVE: To systematically review all relevant literature comparing oncological outcomes of open versus laparoscopic RNU. EVIDENCE ACQUISITION: A systematic literature search using the Medline, Embase, and Cochrane databases and clinicaltrial...
November 15, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29152270/complete-remission-of-chemo-refractory-multiple-metastatic-upper-tract-urothelial-carcinoma-by-autologous-formalin-fixed-tumor-vaccine
#13
Tatsu Miyoshi, Takeshi Kashiwabara, Atsuko Asahi, Tatsuji Kataoka, Takashi Maruyama, Rika Okada, Yoji Uemae, Tadao Ohno
A patient with chemo-refractory multiple-metastatic upper tract urothelial carcinoma (UTUC) treated by monotherapy with autologous formalin-fixed tumor vaccine (AFTV) resulted in complete remission of the lung and para-aortic lymph node metastases (ongoing >3 years after AFTV). The tumor was immunohistologically negative for PD-L1. AFTV will be an attractive treatment option.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29136187/a-phase-iii-trial-of-a-single-early-intravesical-instillation-of-pirarubicin-to-prevent-bladder-recurrence-after-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-jcog1403-utuc-thp-phase-iii
#14
Kenichi Miyamoto, Akihiro Ito, Masashi Wakabayashi, Junko Eba, Yoichi Arai, Hiroyuki Nishiyama, Mikio Sugimoto, Ryo Yamashita, Yoshiyuki Kakehi
Observation is the current standard for managing cases of Stage 0a-III upper tract urothelial carcinoma after radical nephroureterectomy. A randomized Phase III trial commenced in Japan during October 2016. The trial is designed to investigate the superiority of a single early intravesical instillation of pirarubicin, compared with observation, in terms of relapse-free survival after radical nephroureterectomy for Stage 0a-III upper tract urothelial carcinoma. During a 5-year period, 310 patients will be recruited from 43 Japanese institutions...
November 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29135410/tissue-based-molecular-markers-in-upper-tract-urothelial-carcinoma-and-their-prognostic-implications
#15
Ricardo L Favaretto, Stênio C Zequi, Renato A R Oliveira, Thiago Santana, Walter H Costa, Isabela W Cunha, Gustavo C Guimarães
Upper tract urothelial carcinoma (UTUC) is a rare and aggressive disease that is associated with high rates of recurrence and death. Radical nephroureterectomy (RNU) with excision of the bladder cuff is considered the standard of care for high-risk UTUC, whereas kidney-sparing techniques can be indicated for select patients with low-risk disease. There is a significant lack of clinical and pathological prognostic factors for stratifying patients with regard to making treatment decisions. Incorporation of tissue-based molecular markers into prognostic tools could help accurately stratify patients for clinical decision-making in this heterogeneous disease...
November 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29108369/nephroureterectomy-increase-5-year-survival-in-patients-on-dialysis-with-upper-urinary-tract-urothelial-carcinoma
#16
Cih-En Huang, Yao-Hsu Yang, Wen-Cheng Chen, Kuo-Tsai Huang, Pau-Chung Chen, Ying-Huang Tsai, Wei-Yu Lin
Background: There is a high incidence rate of upper tract urothelial carcinoma (UTUC) in patients on dialysis. However, the studies about nephroureterectomy (NU) in this high surgical risk group are limited. The aim of this study is to investigate the outcomes of NU in this population. Results: There were total 931 patients enrolled and 218, 582, 131 patients were non-NU, unilateral and one-stage bilateral NU, respectively. NU provided better 5-year overall survival (66% versus 51% in non-NU, P = 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108329/risk-of-acute-myocardial-infarction-in-upper-tract-urothelial-carcinoma-patients-receiving-radical-nephroureterectomy-a-population-based-cohort-study
#17
Shih-Yi Lin, Cheng-Li Lin, Chao-Hsiang Chang, His-Chin Wu, I-Kuan Wang, Che-Yi Chou, Ji-An Liang
Background: The outcomes of upper tract urothelial carcinoma (UTUC) receiving radical nephroureterectomy were usually limited to small sample size, case-control studies, and often focused on cancer progression. Risk of acute myocardial infarction (AMI) in these patients was never investigated. Results: The overall incidences of AMI were 3.39, 1.44, and 1.70 per 10,000 person-years in the radical nephroureterectomy, nonnephroureterectomy, and non-UTUC cohorts, respectively...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102949/effect-of-preoperative-bacteriuria-and-pyuria-on-intravesical-recurrence-in-patients-with-upper-tract-urothelial-carcinoma-undergoing-radical-nephroureterectomy
#18
Hiroshi Fukushima, Masaki Kobayashi, Keizo Kawano, Shinji Morimoto
BACKGROUND/AIM: We investigated the effect of bacteriuria and pyuria on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). PATIENTS AND METHODS: Preoperative bacteriuria and pyuria were defined as urine containing ≥5 bacteria/high-power field (HPF) and >5 white blood cells/HPF, respectively. Their associations with IVR were evaluated in 97 patients with UTUC undergoing RNU. RESULTS: Preoperative bacteriuria [n=15 (15%)] was significantly associated with preoperative pyuria [n=42 (43%), p<0...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29090027/evaluation-of-multidetector-computed-tomography-in-haematuria
#19
Ranjan Kumar, Raj Kumar Airon, Amit Mittal, Rikki Singal, Kamal Sharma, Samita Singal
AIMS AND OBJECTIVES: (1) To study the role of multidetector computed tomography in patients with haematuria. (2) To correlate multidetector computed tomography findings with clinical outcome/laboratory findings/FNAC and/or operative findings (wherever performed). MATERIAL AND METHODS: The present study was carried out in the Department of Radiodiagnosis, M.M. Institute of Medical Sciences and Research, Mullana, Ambala, from April 2014 to 2016. Fifty patients with complaint of haematuria, referred from various wards and outpatient departments of this institution, were included...
June 2017: Mædica
https://www.readbyqxmd.com/read/29071155/risk-factors-and-prognosis-of-intravesical-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-30-year-single-centre-experience
#20
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Mohamed H Zahran, Samer El-Halwagy, Muftah El Garba, Ahmed M Harraz
OBJECTIVE: To review the incidence, predictors and prognosis of bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013. The tumours were categorised according to the 1997 Tumour-Node-Metastasis (TNM) staging and the three-tiered World Health Organization grading systems. The primary endpoint was the occurrence of any intravesical recurrence after treatment...
September 2017: Arab Journal of Urology
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