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https://www.readbyqxmd.com/read/28538387/prognostic-significance-of-urothelial-carcinoma-with-divergent-differentiation-in-upper-urinary-tract-after-radical-nephroureterectomy-without-metastatic-diseases-a-retrospective-cohort-study
#1
Chuan Qin, En-Li Liang, Zhi-Yong Du, Xiao-Yu Qiu, Gang Tang, Fei-Ran Chen, Bo Zhang, Da-Wei Tian, Hai-Long Hu, Chang-Li Wu
To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537436/utilization-and-outcomes-of-nephroureterectomy-for-upper-tract-urothelial-carcinoma-by-surgical-approach
#2
Joseph Rodriguez, Vignesh T Packiam, William R Boysen, Scott C Johnson, Zacharly L Smith, Norm D Smith, Arieh Shalhav, Gary D Steinberg
OBJECTIVES: To compare outcomes and survival of open, robotic, and laparoscopic nephroureterectomy (ONU, RNU, LNU) using population-based data. METHODS: Using the National Cancer Database, we identified patients who underwent nephroureterectomy for localized UTUC between 2010 and 2013. Demographic and clinicopathologic characteristics were compared among the three operative approaches. Multivariate regression analyses were used to determine the impact of approach on performance of lymphadenectomy (LND), positive surgical margins (PSM), and overall survival (OS)...
May 24, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28525382/sulfatase-1-overexpression-indicates-poor-prognosis-in-urothelial-carcinoma-of-the-urinary-bladder-and-upper-tract
#3
Hsiang-Ying Lee, Bi-Wen Yeh, Ti-Chun Chan, Kei-Fu Yang, Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Hsin-Chih Yeh, Peir-In Liang, Yow-Ling Shiue, Wen-Jeng Wu, Chien-Feng Li
Urothelial carcinoma (UC), arising from the urothelium of the urinary tract, can occur in the upper (UTUC) and the urinary bladder (UBUC). A representative molecular aberration for UC characteristics and prognosis remains unclear. Data mining of Gene Expression Omnibus focusing on UBUC, we identified sulfatase-1 (SULF1) upregulation is associated with UC progression. SULF1 controls the sulfation status of heparan sulfate proteoglycans and plays a role in tumor growth and metastasis, while its role is unexplored in UC...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523296/a-systematic-review-of-the-possible-carcinogenic-role-of-the-aristolochic-acid
#4
Tivadar Bara, Simona Gurzu, Haruhiko Sugimura, Tivadar Bara, Marius Alexandru Beleaua, Ioan Jung
Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28508102/role-of-lymph-node-dissection-during-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-cancer-multi-institutional-large-retrospective-study-jcog1110a
#5
Junichi Inokuchi, Kentaro Kuroiwa, Yoshiyuki Kakehi, Mikio Sugimoto, Toshiki Tanigawa, Hiroyuki Fujimoto, Momokazu Gotoh, Naoya Masumori, Osamu Ogawa, Masatoshi Eto, Chikara Ohyama, Akito Yamaguchi, Hideyasu Matsuyama, Tomohiko Ichikawa, Tomohiko Asano, Junki Mizusawa, Junko Eba, Seiji Naito
PURPOSE: To evaluate the impact of lymph node dissection (LND) on clinical outcome during radical nephroureterectomy (RNU) for patients with upper urinary tract urothelial cancer (UTUC). METHODS: We, the Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG), retrospectively collected data from patients with non-metastatic UTUC who underwent RNU in 30 centers in 1995-2009. Ineligible patients and patients with previous and/or synchronous bladder cancer were excluded, and the remaining 2037 patients were analyzed...
May 15, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28501481/effect-of-lymphadenectomy-during-radical-nephroureterectomy-in-locally-advanced-upper-tract-urothelial-carcinoma
#6
Masaomi Ikeda, Kazumasa Matsumoto, Kazushige Sakaguchi, Daisuke Ishii, Ken-Ichi Tabata, Kazuhiro Kurosawa, Shinji Urakami, Toshikazu Okaneya, Masatsugu Iwamura
BACKGROUND: The role of lymph node dissection (LND) for upper tract urothelial carcinoma (UTUC) patients remains controversial. The aim of this study was to evaluate the effect of LND on clinical outcomes during radical nephroureterectomy (RNU) and to determine prognostic factors of survival. PATIENTS AND METHODS: From 1985 to 2013, 404 patients with UTUC underwent RNU; 5 patients who received neoadjuvant chemotherapy were excluded. Among them, 182 (46%) were pathologically negative for lymph node metastasis (pN0), 177 (44%) were non-LND (pNx), and 40 (10%) were positive for lymph nodes metastasis (pN1/2)...
April 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28483476/prognostic-significance-of-erythrocyte-protein-band-4-1-like5-expression-in-upper-urinary-tract-urothelial-carcinoma
#7
Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto, Ryuichi Mizuno, Akira Miyajima, Yasunori Okada, Hisataka Sabe, Mototsugu Oya
OBJECTIVES: The erythrocyte protein band 4.1-like5 (EPB4.1L5) regulates E-cadherin in cancer invasion and metastasis inducing epithelial-to-mesenchymal transition. This study aimed to investigate the biological significance of EPB4.1L5 in upper urinary tract urothelial carcinoma (UTUC). METHODS: Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues...
May 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28480774/endoscopic-management-of-upper-tract-urothelial-carcinoma
#8
Jay D Raman, Rosa Park
Radical nephroureterectomy with an ipsilateral bladder cuff is the referent standard for management of muscle-invasive, high-grade, or bulky upper-tract urothelial carcinoma (UTUC). Nonetheless, certain patients with UTUC have imperative or elective indications for kidney preservation thereby lending to more conservative strategies for management of this disease. Areas covered: A review of the PubMED and Medline databases was performed to identify original scientific and review articles discussing retrograde ureteroscopic or percutaneous antegrade resection of UTUC tumors published between 1995 and 2016...
May 15, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28418183/evaluation-of-gender-based-disparities-from-initial-hematuria-presentation-to-upper-tract-urothelial-carcinoma-diagnosis-analysis-of-a-nationwide-insurance-claims-database
#9
Meera R Chappidi, Max Kates, Jeffrey J Tosoian, Michael H Johnson, Noah M Hahn, Trinity J Bivalacqua, Phillip M Pierorazio
OBJECTIVE: To investigate the duration from initial hematuria presentation to upper tract urothelial carcinoma (UTUC) diagnosis and the effect of gender on this duration. PATIENTS AND METHODS: Patients with hematuria claims in the year prior to UTUC diagnosis were identified in the MarketScan database (2010-2014). Delayed diagnosis was defined as >90 days from hematuria presentation to UTUC diagnosis. Multivariable Poisson regression models were used to determine factors associated with delayed UTUC diagnosis...
April 18, 2017: BJU International
https://www.readbyqxmd.com/read/28415778/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#10
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415648/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#11
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409437/prognostic-significance-of-pd-l1-expression-on-tumor-cells-and-tumor-infiltrating-mononuclear-cells-in-upper-tract-urothelial-carcinoma
#12
Bo Zhang, Wei Yu, Xueru Feng, Zheng Zhao, Yu Fan, Yisen Meng, Shuai Hu, Yun Cui, Qun He, Hong Zhang, Dong Li, Zhisong He, Liqun Zhou, Jie Jin, Wenke Han
Immunotherapy targeting the programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) pathway has shown promising results in several malignancies. However, the prognostic significance of PD-L1 expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study aimed to evaluate PD-L1 expression and its association with clinicopathological characteristics and oncological outcomes in UTUC patients. PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells (TIMCs), and E-cadherin and N-cadherin expression on tumor cells were assessed by immunohistochemistry in a cohort of 162 patients with UTUC...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28398494/impact-of-lymph-node-dissection-on-clinical-outcomes-during-nephroureterectomy-in-patients-with-clinically-node-negative-upper-urinary-tract-urothelial-cancer-subanalysis-of-a-multi-institutional-nationwide-case-series-of-the-japanese-urological-association
#13
Junichi Inokuchi, Masatoshi Eto, Tomohiko Hara, Hiroyuki Fujimoto, Hiroyuki Nishiyama, Jun Miyazaki, Eiji Kikuchi, Shiro Hinotsu, Takuya Koie, Chikara Ohyama
Objective: To evaluate the impact of lymph node dissection (LND) on the clinical outcomes during radical nephroureterectomy (RNU) in patients with clinically node-negative upper urinary tract urothelial cancer (UTUC). Methods: Within the nationwide case series of the Japanese Urological Association, which comprises 1509 patients with UTUC diagnosed in 2005, we identified 823 patients with clinically node-negative UTUC who underwent RNU. The extent of limited LND was defined as the renal hilar region only for renal pelvic cancer and as either the pelvic region or para-aortic/paracaval region only for ureteral cancer, while the extent of wider LND was defined as at least one perilesional LND region in addition to limited LND...
April 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28397000/efficacy-of-post-nephroureterectomy-cisplatin-based-adjuvant-chemotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma-a-multi-institutional-retrospective-study
#14
Tohru Nakagawa, Yoshimitsu Komemushi, Taketo Kawai, Masafumi Otsuka, Jimpei Miyakawa, Yukari Uemura, Atsushi Kanatani, Satoru Taguchi, Akihiro Naito, Motofumi Suzuki, Hiroaki Nishimatsu, Yoshikazu Hirano, Yoshinori Tanaka, Akihiko Matsumoto, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013 at our four institutions. The patients were divided into two groups: those who received adjuvant chemotherapy (AC group) and those who did not (surgery-alone: SA group)...
April 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28374346/a-novel-technique-to-improve-the-processing-of-minute-ureteroscopic-biopsies
#15
Shay Golan, Glenn Gerber, David Margel, Lea Rath-Wolfson, Yaron Ehrlich, Rumelia Koren, David Lifshitz
To examine the ability of a new specimen handling technique to improve histopathological yield of ureteroscopic biopsies, performed in patients with suspected upper tract urothelial carcinoma (UTUC). In a bi-center retrospective study we compared the results of the new tissue handling technique (group 1) with the standard technique (group 2). In the new technique, to achieve maximal tissue preservation, the specimen is mounted on filter paper prior to embedding in paraffin. Multivariate analysis was performed to determine which factors are associated with optimal histological results...
April 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28373455/comparison-of-efficacy-of-adjuvant-mec-methotrexate-epirubicin-and-cisplatin-and-gc-gemcitabine-and-cisplatin-in-advanced-upper-tract-urothelial-carcinoma
#16
COMPARATIVE STUDY
Sheng-Chun Hung, Shian-Shiang Wang, Chun-Kuang Yang, Jian-Ri Li, Chen-Li Cheng, Yen-Chuan Ou, Hao-Chung Ho, Kun-Yuan Chiu, Chuan-Shu Chen
AIM: To evaluate the efficacy of methotrexate, epirubicin and cisplatin (MEC) or gemcitabine and cisplatin (GC) as adjuvant chemotherapy in advanced upper tract urothelium carcinoma (UTUC). PATIENTS AND METHODS: From 2002 January to 2008 December, a total of 70 patients with advanced UTUC received radical nephroureterctomy at our Institute with MEC and GC as adjuvant chemotherapy. Disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) among the two groups were evaluated...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28364670/alcohol-consumption-and-risk-of-upper-tract-urothelial-cancer
#17
Masayoshi Zaitsu, Ichiro Kawachi, Takumi Takeuchi, Yasuki Kobayashi
BACKGROUND: Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of alcohol consumption in UTUC remains unclear. This study aimed to determine whether alcohol consumption is an independent risk factor for UTUC. METHODS: The study was a case-control study which used the nationwide clinical inpatient database of the Rosai Hospital group in Japan...
March 29, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28355757/-concurrent-renal-cell-carcinoma-and-urothelial-carcinoma-long-term-follow-up-study-of-24-cases
#18
N N Qi, T Li, X H Ning, J C Chen, L Cai, K Gong
Objective: To investigate the clinical manifestation, diagnosis, treatment and outcome of simultaneous occurrence of renal cell carcinoma and urothelial carcinoma. Methods: Twenty-four consecutive patients with synchronous renal cell carcinoma and urothelial carcinoma treated in our center from March 2005 to December 2015 were retrospectively reviewed. Their clinical, pathological and prognostic features were evaluated. Kaplan-Meier curves were used to estimate overall survival. Results: Patient' age was range from 48 to 79 yrs (median 69...
March 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28347659/variant-histology-as-a-significant-predictor-of-survival-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#19
Jung Kwon Kim, Kyung Chul Moon, Chang Wook Jeong, Cheol Kwak, Hyun Hoe Kim, Ja Hyeon Ku
OBJECTIVES: To investigate the effect of variant histology (VH) on survival after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma (UTUC) and the effect of adjuvant chemotherapy on the survival of patients with UTUC with VH. MATERIALS AND METHODS: A total of 452 patients who underwent radical nephroureterectomy for UTUC without neoadjuvant chemotherapy in our institution between 1991 and 2012 were retrospectively analyzed. We performed a comparative analysis between pure UTUC and UTUC with VH groups...
March 24, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28317587/prolonged-pneumoperitoneum-time-is-an-independent-risk-factor-for-intravesical-recurrence-after-laparoscopic-radical-nephroureterectomy-in-upper-tract-urothelial-carcinoma
#20
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
OBJECTIVE: To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). PATIENTS AND METHODS: We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10-12 mmHg to extirpation of the kidney...
March 2017: Surgical Oncology
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