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https://www.readbyqxmd.com/read/28818526/which-patients-with-upper-tract-urothelial-carcinoma-can-be-safely-treated-with-conservative-treatment-by-flexible-ureteroscopy-with-holmium-yag-laser-photoablation-long-term-results-from-a-high-volume-institution
#1
Luca Villa, Mattieu Haddad, Umberto Capitanio, Bhaskar K Somani, Jonathan Cloutier, Steeve Doizi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Olivier Traxer
PURPOSE: To test the effects of tumour size, tumour distribution and tumour grade on progression-free survival (PFS) in patients with upper tract urothelial carcinoma (UTUC) treated with flexible ureteroscopy with Holmium:YAG laser photoablation (FULP). MATERIALS AND METHODS: Data from 92 consecutive UTUC patients treated with FULP (2003-2015) at a single tertiary care referral center were included. A stringent follow-up was offered according to the European Association Urological guidelines...
August 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28816279/-ureteroscope-can-assist-risk-stratification-in-upper-tract-urothelial-carcinoma
#2
R Z Ma, M Qiu, W He, B Yang, H Z Xia, D Zou, M Lu, L L Ma, J Lu
OBJECTIVE: To analyze the efficiency of ureteroscope and biopsy in the diagnosis of tumor grade, muscle-invasiveness and multifocality in suspected upper tract urinary carcinoma (UTUC) patients in order to find out whether it can be used in the risk stratification of UTUC patients. METHODS: A retrospective study of 76 UTUC patients who underwent preoperative ureteroscope and/or biopsy and received radical nephroureterectomy in Peking University Third Hospital during January 2014 to December 2016 was undertaken...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28816273/-prognostic-factors-of-patients-with-t2n0m0-upper-tract-urothelial-carcinoma-a-single-center-retrospective-study-of-235-patients
#3
B Guan, Z P Cao, D Peng, Y F Li, Y H Zhan, L B Liu, S M He, G Y Xiong, X S Li, L Q Zhou
OBJECTIVE: To evaluate the impacts of the prognostic factors of T2N0M0 upper tract urothelial carcinoma (UTUC) for Chinese patients. METHODS: A retrospective study was conducted including 235 patients who were diagnosed with T2N0M0 UTUC in our hospital and received radical nephroureterectomy (RNU) or partial ureterectomy during January 2000 and December 2013. The 3 and 5-year cancer-specific survival rates and bladder recurrence-free survival rates of all the patients were valued using Kaplan-Meier method, and the survival curves with statistical significance between the two were compared using the Log-rank test...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28807244/endoscopic-management-of-upper-tract-urothelial-carcinoma-improved-prediction-of-invasive-cancer-using-a-ureteroscopic-scoring-model
#4
Seong Soo Jeon, Hyun Hwan Sung, Hwang Gyun Jeon, Deok Hyun Han, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han-Yong Choi
BACKGROUND: The aim of this study was to investigate clinical and ureteroscopic factors considered as important for the prediction of invasive upper tract urothelial carcinoma (UTUC) and establish a model using a new ureteroscopic scoring. METHODS: We analyzed tumor depth and grade from ureteroscopic biopsies in 172 patients who underwent imaging studies, urine cytology, and radical nephroureterectomy. Invasive UTUC was defined as muscle-invasive or non-organ confined tumors...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28799728/the-combined-application-of-urinary-liquid-based-cytology-with-fluorescence-in-situ-hybridization-and-p16-ki-67-dual-immunostaining-is-valuable-for-improving-the-early-diagnosis-of-upper-tract-urothelial-carcinomas
#5
Xueqi Sun, Xubin Liu, Meng Xia, Shicong Yang, Lingyan Fei, Mengqi Zhang, Hanyu Ma, Liantang Wang, Shangwu Chen, Li Yu
OBJECTIVES: To evaluate the diagnostic values of urine liquid-based cytology (LBC), fluorescence in situ hybridization (FISH), and p16/Ki-67 dual immunostaining in the detection of upper tract urothelial carcinomas (UTUCs). METHODS: Sixty-one patients with UTUCs were retrospectively analyzed. All patients were diagnosed both by urine cytology and by FISH, and histologically confirmed as UTUCs. Thirty-two patients had been stained with p16/Ki-67 dual labeling. RESULTS: The sensitivities for low-grade UTUCs (LGUTUCs) and high-grade UTUCs (HGUTUCs) were 33...
August 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28797715/universal-point-of-care-testing-for-lynch-syndrome-in-patients-with-upper-tract-urothelial-carcinoma
#6
Michael J Metcalfe, Firas G Petros, Priya Rao, Maureen E Mork, Lianchun Xiao, Russell R Broaddus, Surena F Matin
BACKGROUND: Patients with Lynch syndrome (LS) are at risk for upper tract urothelial carcinoma (UTUC). We aim to identify the most reliable means of point-of-care (POC) screening for LS in UTUC patients. METHODS: From January 2013 through July 2016, 115 consecutive UTUC patients without a history of LS were universally screened during their follow-up. We evaluated patient/family history (Amsterdam criteria I [AMS1] and II [AMS2]), tumor immunohistochemistry (IHC) for mismatch repair proteins (MMRP), and microsatellite instability (MSI)...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28762779/editorial-comment-on-end-2016-0871-or-r2-role-of-mitomycin-c-mmc-topical-treatment-for-upper-tract-urothelial-carcinoma-utuc
#7
Bhaskar K Somani
While adjuvant topical mitomycin C (MMC) is well established in realms of bladder cancer, its use in upper tract urothelial tumours (UTUC) is still somewhat limited with only few series reported worldwide. The authors present their series of 27 patients (28 renal units) on the role of adjuvant MMC after complete endoscopic control of UTUC with a median follow-up of 19 months (7-92 months). Their recurrence free survival of 62% at 3 years represents a medium term favourable result, especially in low-grade tumours...
August 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28762118/laparoscopic-and-robotic-nephroureterectomy-does-lymphadenectomy-have-an-impact-on-the-clinical-outcome
#8
Nessn H Azawi, Kasper Drimer Berg, Andreas Key Milan Thamsborg, Claus Dahl, Jan Viberg Jepsen, Bjarne Kroman-Andersen, Johan Poulsen, Helle Handler Petersen, L Henning Olsen, Jørgen Bjerggaard Jensen
PURPOSE: To evaluate the effect of lymphadenectomy (LND) in conjunction with nephroureterectomy on cancer-specific mortality (CSM) and overall survival (OS) for patients with muscle-invasive UTUC. METHODS: A retrospective, multicenter study of patients with UTUC, clinical stage N0M0, who underwent nephroureterectomy between January 2008 and December 2014 was conducted. Outcome measures were OS and CSM. RESULTS: In total, 298 patients underwent robot-assisted or laparoscopic radical nephroureterectomy with a final histological diagnosis of UTUC...
July 31, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28761589/the-role-of-urinary-cytology-when-diagnostic-workup-is-suspicious-for-upper-tract-urothelial-carcinoma-but-tumour-biopsy-is-nonconfirmatory
#9
David Horovitz, Yifan Meng, Jean V Joseph, Changyong Feng, Guan Wu, Hani Rashid, Edward M Messing
INTRODUCTION: We sought to determine the value of obtaining preoperative urinary cytology when diagnostic workup of an upper tract mass is suspicious for upper tract urothelial carcinoma (UTUC), but biopsy fails to confirm the diagnosis. METHODS: Using billing code data, 239 patients were identified as having undergone radical nephroureterectomy (RNU) by 16 urologists from September 29, 1998 to July 31, 2015. Of this group, 19 adult patients had a presumed preoperative diagnosis of UTUC in a native kidney, at least three months of followup, no history of concurrent radical cystectomy with RNU, and negative/non-diagnostic tissue biopsy...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28755093/her2-and-top2a-gene-amplification-and-protein-expression-in-upper-tract-urothelial-carcinomas
#10
Klaus Aumayr, Tobias Klatte, Barbara Neudert, Peter Birner, Shahrokh Shariat, Manuela Schmidinger, Martin Susani, Andrea Haitel
HER2, a potential target for therapy, has been described to be amplified in urothelial carcinomas. As the topoisomerase II alpha (TOP2A) gene is located close to the HER2 gene on chromosome 17q12-q21, it is frequently either co-amplified or deleted with HER2 amplification. The purpose of this study was to assess the impact HER2 and TOP2A gene amplification as well as protein expression on outcomes of upper tract urothelial carcinoma (UTUC). HER2 and TOP2A gene amplification and protein expression were assessed in 81 patients with radical nephroureterectomy for UTUC...
July 28, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28753881/platinum-based-neoadjuvant-chemotherapy-improves-oncological-outcomes-in-patients-with-locally-advanced-upper-tract-urothelial-carcinoma
#11
Shogo Hosogoe, Shingo Hatakeyama, Ayumu Kusaka, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
BACKGROUND: Neoadjuvant chemotherapy (NAC) use for patients with locally advanced upper tract urothelial carcinoma (UTUC) is debatable. OBJECTIVE: To investigate the efficacy and safety of platinum-based NAC for locally advanced UTUC. DESIGN, SETTINGS, AND PARTICIPANTS: Of 233 consecutive patients who underwent radical nephroureterectomy, 55 patients received NAC (NAC group) and 138 patients did not (Ctrl group). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The two arms (Ctrl vs NAC) were matched using propensity scores to minimize selection bias...
April 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753840/caveolin-1-expression-in-upper-tract-urothelial-carcinoma
#12
David D'Andrea, Marco Moschini, Beat Foerster, Mohammad Abufaraj, Vitaly Margulis, Jose Karam, Yair Lotan, Jay Raman, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Andrea Haitel, Sharhrokh F Shariat
BACKGROUND: Improvement in postoperative risk stratification of upper tract urothelial carcinoma (UTUC) is required to better predict outcomes and counsel patients on adjuvant treatment. OBJECTIVE: To validate the association between caveolin-1 and oncological outcomes in patients treated with radical nephroureterectomy (RNU) for UTUC. DESIGN, SETTING, AND PARTICIPANTS: Caveolin-1 expression was evaluated via immunochemistry on a tissue microarray from 621 patients...
July 1, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753826/programmed-death-ligand-1-expression-in-upper-tract-urothelial-carcinoma
#13
Stephanie L Skala, Tzu-Ying Liu, Aaron M Udager, Alon Z Weizer, Jeffrey S Montgomery, Ganesh S Palapattu, Javed Siddiqui, Xuhong Cao, Kristina Fields, Ahmed E Abugharib, Moaaz Soliman, Khaled S Hafez, David Miller, Cheryl T Lee, Ajjai Alva, Arul M Chinnaiyan, Todd M Morgan, Daniel E Spratt, Hui Jiang, Rohit Mehra
BACKGROUND: Urothelial carcinoma (UC) is the most common malignancy of the urinary tract. Upper tract (renal pelvis and ureter) urothelial carcinomas (UTUC) account for approximately 5% of UCs but a significant subset are invasive and associated with poor clinical outcomes. OBJECTIVE: To evaluate programmed death-ligand 1 (PD-L1) expression in UTUC. DESIGN, SETTING, AND PARTICIPANTS: UTUC cases from 1997-2016 were retrospectively identified from the surgical pathology database at a single large academic institution...
December 13, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753800/correlation-between-confocal-laser-endomicroscopy-cellvizio-%C3%A2-and-histological-grading-of-upper-tract-urothelial-carcinoma-a-step-forward-for-a-better-selection-of-patients-suitable-for-conservative-management
#14
Alberto Breda, Angelo Territo, Andrea Guttilla, Francesco Sanguedolce, Martina Manfredi, Luigi Quaresima, Jose M Gaya, Ferran Algaba, Joan Palou, Humberto Villavicencio
BACKGROUND: Despite the recent growing interest in the conservative management of upper tract urothelial carcinoma (UTUC), the diagnostic process is still a challenge for the risk of tumor undergrading. Real-time confocal laser endomicroscopy (CLE) provides in vivo microscopic images of tissues using a low-energy laser light source. OBJECTIVE: To describe our initial experience with CLE for the real-time characterization of UTUC. DESIGN, SETTING, AND PARTICIPANTS: Fourteen flexible ureteroscopies (f-URS) were performed at our center with CLE for UTUC...
June 4, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28751166/clinical-and-demographic-characteristics-among-patients-with-urothelial-carcinomas-of-the-upper-urinary-tract-and-bladder-in-taiwan
#15
Cheng-Huang Shen, Hung-Yi Chiou, Min-Che Tung, Chia-Chang Wu, Wei-Tang Kao, Yuan-Hung Wang, Guang-Dar Juang
BACKGROUND: Urothelial carcinoma (UC) is derived from the urothelium of the urinary tract, and includes cancers of the bladder, renal pelvis and ureter. The aim of this study was to investigate the clinical and demographic features among patients with bladder cancer and urothelial carcinoma of the upper urinary tract (UTUC) in Taiwan. METHODS: The present study recruited a total of 736 histopathologically confirmed UC cases, which consisted of 470 bladder cancer and 266 UTUC between September 1998 and December 2009...
July 24, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28731777/induction-and-maintenance-adjuvant-mitomycin-c-topical-therapy-for-upper-tract-urothelial-carcinoma-tolerability-and-intermediate-term-outcomes
#16
Michael Metcalfe, Gavin Wagenheim, Lianchun Xiao, John Papadopoulos, Neema Navai, John W Davis, Jose A Karam, Ashish M Kamat, Christopher G Wood, Colin P Dinney, Surena F Matin
PURPOSE: Endoscopic management of upper tract urothelial carcinoma (UTUC) is associated with higher recurrences, which could be reduced by application of topical therapy. Adjuvant induction Bacillus Calmette-Guerin has shown inferior outcomes for UTUC compared to bladder cancer, and maintenance regimens for UTUC are unexplored. We report on the efficacy, safety, and tolerability of Mitomycin C (MMC) induction and maintenance adjuvant topical therapy for UTUC. MATERIALS AND METHODS: Patients with UTUC who received adjuvant topical therapy after complete endoscopic control of Ta/T1 tumors were retrospectively reviewed...
July 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28720865/immunology-pd-1-and-pd-l1-prognostic-in-utuc
#17
Louise Stone
No abstract text is available yet for this article.
July 18, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28714362/impact-of-tumor-architecture-on-disease-recurrence-and-cancer-specific-mortality-of-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#18
Bo Fan, Bin Hu, Qingmin Yuan, Shuang Wen, Tianqing Liu, Shanshan Bai, Xiaofeng Qi, Xin Wang, Deyong Yang, Xiuzhen Sun, Xishuang Song
Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. Recent publications have assessed the prognostic significance of tumor architecture in UTUC, but there is still controversy regarding the significance and importance of tumor architecture on disease recurrence. We retrospectively reviewed the medical records of 101 patients with clinical UTUC who had undergone surgery. Univariate and multivariate analyses were conducted to identify factors associated with disease recurrence and cancer-specific mortality...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28709887/frequency-and-prognostic-value-of-pten-loss-in-patients-with-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#19
Malte Rieken, Shahrokh F Shariat, Jose A Karam, Beat Foerster, Francesca Khani, Kilian Gust, Mohammad Abufaraj, Christopher G Wood, Alon Z Weizer, Jay D Raman, Charles C Guo, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan, Alexander Bachmann, Angelo M De Marzo, Brian D Robinson, Vitaly Margulis
PURPOSE: The frequency and prognostic significance of phosphatase and tensin homolog (PTEN) protein expression in upper tract urothelial carcinoma (UTUC) have not been investigated yet in large studies. To analyze PTEN protein status and its association with disease recurrence and survival outcomes in a large, multi-institutional UTUC cohort. MATERIALS AND METHODS: Retrospective analysis of 611 patients with UTUC treated with radical nephroureterectomy (RNU) between 1991 and 2008 at seven institutions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28694147/predictive-and-prognostic-value-of-preoperative-thrombocytosis-in-upper-tract-urothelial-carcinoma
#20
Beat Foerster, Marco Moschini, Mohammad Abufaraj, Francesco Soria, Kilian M Gust, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Michael Rink, Luis Kluth, Romain Mathieu, Vitaly Margulis, Yair Lotan, Atiqullah Aziz, Hubert John, Shahrokh F Shariat
PURPOSE: The purpose of this study was to evaluate the predictive and prognostic role of preoperative thrombocytosis (TC) in upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU) in a large multi-institutional cohort of patients. METHODS: Records of 2492 patients undergoing RNU for non-metastatic UTUC between 1990 and 2008 were retrospectively analyzed. Preoperative TC was defined as a platelet count > 400 × 10(9)/L, irrespective of gender type...
June 19, 2017: Clinical Genitourinary Cancer
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