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https://www.readbyqxmd.com/read/28634017/the-over-time-conditional-survival-of-intravesical-recurrence-in-upper-tract-urothelial-carcinoma
#1
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
PURPOSE: Since a conditional survival (CS) analysis provides better estimates of survival times at each follow-up, we aimed to assess changes in conditional intravesical recurrence-free survival (IVRFS) rates after radical nephroureterectomy (RNU) and how the impact of well-known risk factors evolves over time, particularly in localized upper tract urothelial carcinoma (UTUC) patients. MATERIALS AND METHODS: We identified 364 patients with Ta-3N0M0 UTUC who underwent open or laparoscopic RNU at our three institutions...
June 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28604991/ureteroscopy-in-the-diagnosis-of-upper-tract-transitional-cell-cancer-a-10-year-experience-providing-outcome-data-for-informed-consent
#2
Luke Hanna, Vera Chung, Ahmed Ali, Robert Ritchie, Ann Rogers, Mark Sullivan, Stephen Keoghane
PURPOSE: The aim of the study was to assess the effectiveness of ureteroscopy and biopsy in the diagnosis and management of upper tract urothelial carcinoma. METHODS: We retrospectively collated data from pathology, radiology and operating theatre data sets from two large UK hospitals. During the 10-year period examined, 160 patients underwent ureteroscopy prior to nephro-ureterectomy (NU)/distal ureterectomy (DU). RESULTS: Of the 160 patients identified, 140 were ureteroscopically evaluated and biopsied, 104 (74...
June 7, 2017: Urologia
https://www.readbyqxmd.com/read/28601352/comprehensive-genomic-characterization-of-upper-tract-urothelial-carcinoma
#3
Tyler J Moss, Yuan Qi, Liu Xi, Bo Peng, Tae-Beom Kim, Nader E Ezzedine, Maribel E Mosqueda, Charles C Guo, Bogdan A Czerniak, Michael Ittmann, David A Wheeler, Seth P Lerner, Surena F Matin
BACKGROUND: Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer. OBJECTIVE: To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses. DESIGN, SETTING, AND PARTICIPANTS: We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome sequencing (WES) of DNA, RNA sequencing (RNAseq), and protein analysis...
June 7, 2017: European Urology
https://www.readbyqxmd.com/read/28583528/human-polyomavirus-is-associated-with-earlier-onset-of-upper-urinary-tract-urothelial-carcinoma-in-patients-after-kidney-transplantation
#4
H L Luo, Y T Chen, S C Huang, T C Chen, P H Chiang, S S Lin, Y T Cheng
OBJECTIVES: Polyomavirus has been reported to be oncogenic due to viral integration into the human genome. A relatively high prevalence of upper urinary tract urothelial carcinoma (UTUC) was noted after kidney transplantation (KT) in Taiwan. However, little was known about the impact of polyomavirus on the urothelial cancer behavior. Therefore, the aim of this study is to analyze the characteristics of polyomavirus-related UTUC after KT. METHODS: From 2005 to 2014, 27 patients were found to have UTUCs after KT...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28583527/using-hematuria-as-detection-of-post-kidney-transplantation-upper-urinary-tract-urothelial-carcinoma-is-associated-with-delayed-diagnosis-of-cancer-occurrence
#5
S H Lin, H L Luo, Y T Chen, Y T Cheng
OBJECTIVES: Kidney transplantation (KT) is an important renal replacement therapy for end-stage renal disease (ESRD). The incidence of upper urinary tract urothelial carcinoma (UTUC) is relatively higher in Taiwan. According to our institutional database, early onset of post-KT UTUC is not uncommon. Early detection of post-KT UTUC is an important issue to improve oncologic outcome. Because painless hematuria is a common symptom for UTUC, this study analyzes whether using hematuria as post-KT UTUC screening delayed cancer diagnosis or not...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28579283/optimizing-management-of-upper-tract-urothelial-carcinoma
#6
REVIEW
Matthew T Campbell, Amishi Y Shah, Surena F Matin, Arlene O Siefker-Radtke
Upper tract urothelial cancer (UTUC) is a rare cancer of the urothelium, comprising only a fraction of cases as compared to urothelial tumors of the bladder. As a result, systemic treatment approaches in bladder cancer are often applied to patients with UTUC. Given the anatomical location of these tumors, the age, the comorbid conditions of these patients with UTUC, and the need for radical nephroureterectomy for treatment, most patients have substantial impairment of renal reserve. There is growing evidence for the benefit of perioperative chemotherapy in this disease...
June 1, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28574835/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#7
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, A Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28552573/evaluation-of-the-clinical-utility-of-renin-angiotensin-system-inhibitors-in-patients-undergoing-radical-surgery-for-urothelial-carcinoma-of-the-upper-urinary-tract
#8
Takashi Yoshida, Tomoaki Matsuzaki, Takashi Murota, Gen Kawa, Tadashi Matsuda, Hidefumi Kinoshita
BACKGROUND: Renin-angiotensin system (RAS) inhibitors are effective for treating patients with cancer. The present study evaluated the impact of RAS inhibitors, including angiotensin-2 converting enzyme inhibitors and angiotensin 2 receptor blockers, after patients underwent radical surgery for upper urinary tract urothelial carcinoma (UTUC). METHODS: This retrospective study included 312 patients with nonmetastatic UTUC who underwent radical surgery. The oncological outcomes of patients treated or not treated with RAS inhibitors following surgery were evaluated...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28538387/prognostic-significance-of-urothelial-carcinoma-with-divergent-differentiation-in-upper-urinary-tract-after-radical-nephroureterectomy-without-metastatic-diseases-a-retrospective-cohort-study
#9
Chuan Qin, En-Li Liang, Zhi-Yong Du, Xiao-Yu Qiu, Gang Tang, Fei-Ran Chen, Bo Zhang, Da-Wei Tian, Hai-Long Hu, Chang-Li Wu
To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537436/utilization-and-outcomes-of-nephroureterectomy-for-upper-tract-urothelial-carcinoma-by-surgical-approach
#10
Joseph Rodriguez, Vignesh T Packiam, William R Boysen, Scott C Johnson, Zacharly L Smith, Norm D Smith, Arieh Shalhav, Gary D Steinberg
OBJECTIVES: To compare outcomes and survival of open, robotic, and laparoscopic nephroureterectomy (ONU, RNU, LNU) using population-based data. METHODS: Using the National Cancer Database, we identified patients who underwent nephroureterectomy for localized UTUC between 2010 and 2013. Demographic and clinicopathologic characteristics were compared among the three operative approaches. Multivariate regression analyses were used to determine the impact of approach on performance of lymphadenectomy (LND), positive surgical margins (PSM), and overall survival (OS)...
May 24, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28525382/sulfatase-1-overexpression-indicates-poor-prognosis-in-urothelial-carcinoma-of-the-urinary-bladder-and-upper-tract
#11
Hsiang-Ying Lee, Bi-Wen Yeh, Ti-Chun Chan, Kei-Fu Yang, Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Hsin-Chih Yeh, Peir-In Liang, Yow-Ling Shiue, Wen-Jeng Wu, Chien-Feng Li
Urothelial carcinoma (UC), arising from the urothelium of the urinary tract, can occur in the upper (UTUC) and the urinary bladder (UBUC). A representative molecular aberration for UC characteristics and prognosis remains unclear. Data mining of Gene Expression Omnibus focusing on UBUC, we identified sulfatase-1 (SULF1) upregulation is associated with UC progression. SULF1 controls the sulfation status of heparan sulfate proteoglycans and plays a role in tumor growth and metastasis, while its role is unexplored in UC...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523296/a-systematic-review-of-the-possible-carcinogenic-role-of-the-aristolochic-acid
#12
Tivadar Bara, Simona Gurzu, Haruhiko Sugimura, Tivadar Bara, Marius Alexandru Beleaua, Ioan Jung
Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28508102/role-of-lymph-node-dissection-during-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-cancer-multi-institutional-large-retrospective-study-jcog1110a
#13
Junichi Inokuchi, Kentaro Kuroiwa, Yoshiyuki Kakehi, Mikio Sugimoto, Toshiki Tanigawa, Hiroyuki Fujimoto, Momokazu Gotoh, Naoya Masumori, Osamu Ogawa, Masatoshi Eto, Chikara Ohyama, Akito Yamaguchi, Hideyasu Matsuyama, Tomohiko Ichikawa, Tomohiko Asano, Junki Mizusawa, Junko Eba, Seiji Naito
PURPOSE: To evaluate the impact of lymph node dissection (LND) on clinical outcome during radical nephroureterectomy (RNU) for patients with upper urinary tract urothelial cancer (UTUC). METHODS: We, the Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG), retrospectively collected data from patients with non-metastatic UTUC who underwent RNU in 30 centers in 1995-2009. Ineligible patients and patients with previous and/or synchronous bladder cancer were excluded, and the remaining 2037 patients were analyzed...
May 15, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28501481/effect-of-lymphadenectomy-during-radical-nephroureterectomy-in-locally-advanced-upper-tract-urothelial-carcinoma
#14
Masaomi Ikeda, Kazumasa Matsumoto, Kazushige Sakaguchi, Daisuke Ishii, Ken-Ichi Tabata, Kazuhiro Kurosawa, Shinji Urakami, Toshikazu Okaneya, Masatsugu Iwamura
BACKGROUND: The role of lymph node dissection (LND) for upper tract urothelial carcinoma (UTUC) patients remains controversial. The aim of this study was to evaluate the effect of LND on clinical outcomes during radical nephroureterectomy (RNU) and to determine prognostic factors of survival. PATIENTS AND METHODS: From 1985 to 2013, 404 patients with UTUC underwent RNU; 5 patients who received neoadjuvant chemotherapy were excluded. Among them, 182 (46%) were pathologically negative for lymph node metastasis (pN0), 177 (44%) were non-LND (pNx), and 40 (10%) were positive for lymph nodes metastasis (pN1/2)...
April 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28483476/prognostic-significance-of-erythrocyte-protein-band-4-1-like5-expression-in-upper-urinary-tract-urothelial-carcinoma
#15
Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto, Ryuichi Mizuno, Akira Miyajima, Yasunori Okada, Hisataka Sabe, Mototsugu Oya
OBJECTIVES: The erythrocyte protein band 4.1-like5 (EPB4.1L5) regulates E-cadherin in cancer invasion and metastasis inducing epithelial-to-mesenchymal transition. This study aimed to investigate the biological significance of EPB4.1L5 in upper urinary tract urothelial carcinoma (UTUC). METHODS: Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues...
May 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28480774/endoscopic-management-of-upper-tract-urothelial-carcinoma
#16
REVIEW
Jay D Raman, Rosa Park
Radical nephroureterectomy with an ipsilateral bladder cuff is the referent standard for management of muscle-invasive, high-grade, or bulky upper-tract urothelial carcinoma (UTUC). Nonetheless, certain patients with UTUC have imperative or elective indications for kidney preservation thereby lending to more conservative strategies for management of this disease. Areas covered: A review of the PubMED and Medline databases was performed to identify original scientific and review articles discussing retrograde ureteroscopic or percutaneous antegrade resection of UTUC tumors published between 1995 and 2016...
June 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28418183/evaluation-of-gender-based-disparities-from-initial-hematuria-presentation-to-upper-tract-urothelial-carcinoma-diagnosis-analysis-of-a-nationwide-insurance-claims-database
#17
Meera R Chappidi, Max Kates, Jeffrey J Tosoian, Michael H Johnson, Noah M Hahn, Trinity J Bivalacqua, Phillip M Pierorazio
OBJECTIVE: To investigate the duration from initial hematuria presentation to upper tract urothelial carcinoma (UTUC) diagnosis and the effect of gender on this duration. PATIENTS AND METHODS: Patients with hematuria claims in the year prior to UTUC diagnosis were identified in the MarketScan database (2010-2014). Delayed diagnosis was defined as >90 days from hematuria presentation to UTUC diagnosis. Multivariable Poisson regression models were used to determine factors associated with delayed UTUC diagnosis...
April 18, 2017: BJU International
https://www.readbyqxmd.com/read/28415778/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#18
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415648/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#19
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409437/prognostic-significance-of-pd-l1-expression-on-tumor-cells-and-tumor-infiltrating-mononuclear-cells-in-upper-tract-urothelial-carcinoma
#20
Bo Zhang, Wei Yu, Xueru Feng, Zheng Zhao, Yu Fan, Yisen Meng, Shuai Hu, Yun Cui, Qun He, Hong Zhang, Dong Li, Zhisong He, Liqun Zhou, Jie Jin, Wenke Han
Immunotherapy targeting the programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) pathway has shown promising results in several malignancies. However, the prognostic significance of PD-L1 expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study aimed to evaluate PD-L1 expression and its association with clinicopathological characteristics and oncological outcomes in UTUC patients. PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells (TIMCs), and E-cadherin and N-cadherin expression on tumor cells were assessed by immunohistochemistry in a cohort of 162 patients with UTUC...
May 2017: Medical Oncology
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