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https://www.readbyqxmd.com/read/28074261/perioperative-chemotherapy-in-upper-tract-urothelial-carcinoma-a-comprehensive-review
#1
REVIEW
Atiqullah Aziz, Jakub Dobruch, Kees Hendricksen, Luis A Kluth, Andrea Necchi, Aidan Noon, Michael Rink, Florian Roghmann, Roland Seiler, Paolo Gontero, Wassim Kassouf, Shahrokh F Shariat, Evanguelos Xylinas
PURPOSE: To evaluate the role of neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). METHODS: A comprehensive review of the current literature was performed searching for all studies investigating NAC and AC in UTUC in MEDLINE and https://clinicaltrials.gov , prior to April 2016. The following keywords were used: "ureteral neoplasms," "urothelium," "ureter," "upper tract urothelial," "chemotherapy," "adjuvant," "neoadjuvant" and relevant variants...
January 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28049247/impact-of-the-asa-physical-status-score-on-adjuvant-chemotherapy-eligibility-and-survival-of-upper-tract-urothelial-carcinoma-patients-a-multicenter-study
#2
Ho Won Kang, Sung Pil Seo, Won Tae Kim, Yong June Kim, Seok Joong Yun, Sang Cheol Lee, Young Deuk Choi, Yun Sok Ha, Tae Hwan Kim, Tae Gyun Kwon, Seok Soo Byun, Seong Uk Jeh, Wun Jae Kim
The aim of the present multi-institutional study was to assess the influence of the American Society of Anesthesiologists Physical Status (ASA-PS) classification on adjuvant chemotherapy eligibility and survival in a multi-institutional cohort of patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). We retrospectively reviewed data from 416 patients who underwent RNU for UTUC at four Korean institutions between 2001 and 2013. The ASA-PS classification was obtained from the anesthesia chart...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28045620/effectiveness-of-adjuvant-chemotherapy-after-radical-nephroureterectomy-for-locally-advanced-and-or-positive-regional-lymph-node-upper-tract-urothelial-carcinoma
#3
Thomas Seisen, Ross E Krasnow, Joaquim Bellmunt, Morgan Rouprêt, Jeffrey J Leow, Stuart R Lipsitz, Malte W Vetterlein, Mark A Preston, Nawar Hanna, Adam S Kibel, Maxine Sun, Toni K Choueiri, Quoc-Dien Trinh, Steven L Chang
Purpose There is limited evidence to support the use of adjuvant chemotherapy (AC) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Against this backdrop, we hypothesized that such treatment is associated with overall survival (OS) benefit in patients with locally advanced and/or positive regional lymph node disease. Patients and Methods Within the National Cancer Database (2004 to 2012), we identified 3,253 individuals who received AC or observation after RNU for pT3/T4 and/or pN+ UTUC...
January 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28041996/utilizaton-of-perioperative-systemic-chemotherapy-in-upper-tract-urothelial-carcinoma
#4
Greg E Gin, Nora H Ruel, Steven V Kardos, John P Sfakianos, Edward Uchio, Clayton S Lau, Bertram E Yuh
INTRODUCTION: Evidence for the use of perioperative chemotherapy (PC) in upper tract urothelial carcinoma (UTUC) is largely derived from level I evidence for invasive urothelial carcinoma of the bladder (UCB). There has been an increase in PC for urothelial carcinoma of the bladder, as it has disseminated into clinical practice. Therefore, we sought to not only analyze trends in the utilization of PC in UTUC, but also assess factors associated with its use in a large cancer registry database...
December 29, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/28006766/is-overexpression-of-ki-67-a-prognostic-biomarker-of-upper-tract-urinary-carcinoma-a-retrospective-cohort-study-and-meta-analysis
#5
Bo Fan, Hongshuo Zhang, Huidan Jin, Yu Gai, Honglong Wang, Huafeng Zong, Mingyu Jin, Hao Yang, Shuping Wan, Jiabin Zhu, Siyao Xu, Jianbo Wang, Deyong Yang, Xishuang Song
BACKGROUND: Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. The Ki-67 antigen is a classic marker of cellular proliferation, but there is still controversy regarding the significance and importance of Ki-67 in tumor progression. METHODS: In this study, we first detected Ki-67 expression in UTUC patients by immunohistochemistry (IHC). Subsequently, we quantitatively combined the results with those from the published literature in a meta-analysis after searching several databases...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27994654/downregulation-of-rnf128-predicts-progression-and-poor-prognosis-in-patients-with-urothelial-carcinoma-of-the-upper-tract-and-urinary-bladder
#6
Yi-Ying Lee, Chieh-Tien Wang, Steven Kuan-Hua Huang, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Chien-Feng Li
Background: The TP53 tumor suppressor gene plays a crucial role in the carcinogenesis of many malignancies, including urothelial carcinoma (UC). Overexpression of p53 is associated with poor prognosis in UC. Recently, RING finger protein 128 (RNF128) was shown to be involved in p53-induced apoptosis, forming a negative feedback loop. However, the significance of RNF128 in patients with UC remains unknown. In this study, our aim was to evaluate the expression of RNF128 in UC and to assess its predictive and prognostic value in a well-established cohort...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27987509/-preoperative-prognostic-factors-and-preoperative-risk-stratification-of-upper-tract-urothelial-carcinoma
#7
Y C Xing, G Y Xiong, D Fang, Z Zhang, L Cai, L Zhang, Z S He, X S Li, L Q Zhou
OBJECTIVE: To identify the preoperative prognostic factors of upper tract urothelial carcinoma (UTUC) and construct preoperative risk stratification system. METHODS: A retrospective study including 686 patients who were diagnosed with UTUC and received radical nephroureterectomy or partial ureterectomy in Peking University First Hospital during 2003 and 2013. RESULTS: Of the 686 UTUC patients, 303 (44.2%) were male and 383 (55.8%) female. The postoperative pathological examination showed that 203 (29...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27958391/diagnostic-dilemmas-in-patients-with-upper-tract-urothelial-carcinoma
#8
REVIEW
Joyce Baard, Daniel M de Bruin, Patricia J Zondervan, Guido Kamphuis, Jean de la Rosette, M Pilar Laguna
Upper tract urothelial carcinoma (UTUC) is a rare condition and recommendations based on a high level of evidence for diagnosis, treatment and follow-up monitoring are lacking. Current decision-making is often based on evidence from trials investigating urothelial carcinoma of the lower tract. Radical nephroureterectomy has been the standard of care for UTUC but kidney-sparing treatment using endoscopic approaches has been established for a select patient group with low-grade and low-stage disease. Optimal treatment choice requires correct tumour characterization...
December 13, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27932270/prognostic-value-of-lymph-node-yield-during-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#9
Andrew G Winer, Emily A Vertosick, Mazyar Ghanaat, Renato B Corradi, Sigrid Carlsson, Daniel D Sjoberg, Alexander I Sankin, John P Sfakianos, Eugene K Cha, Guido Dalbagni, Jonathan A Coleman
INTRODUCTION: Lymph node dissection (LND) performed during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) remains controversial and difficult to evaluate. The aim of this study was to investigate whether removal of more lymph nodes during RNU is safe and improves oncologic outcomes. METHODS: We evaluated 422 patients who underwent RNU with concomitant LND for upper tract urothelial carcinoma between 1976 and 2015, assessing for an association between total nodes removed, recurrence-free survival, and cancer-specific survival using Cox proportional hazards models...
December 5, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27910890/adjuvant-radiotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma
#10
Yun-Ching Huang, Ying-Hsu Chang, Kuo-Hsiung Chiu, Alan W Shindel, Chia-Hsuan Lai
There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively reviewed 198 patients treated with RNU between December 2001 and January 2015. Postoperative radiotherapy was administered in 40 (20.2%) of patients. Patients who received radiotherapy were younger than those that did not (65...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906675/preoperative-serum-pre-albumin-as-an-independent-prognostic-indicator-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#11
Jiwei Huang, Yanqing Wang, Yichu Yuan, Yong-Hui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang
PURPOSE: To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy. METHODS AND MATERIALS: Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level was defined as <20 mg/dl, while hypoalbuminemia was defined as albumin <35 g/L...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901490/prognostic-value-of-preoperative-plasma-fibrinogen-level-and-platelet-to-lymphocyte-ratio-f-plr-in-patients-with-localized-upper-tract-urothelial-carcinoma
#12
Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang
PURPOSE: Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887951/a-multi-institutional-comparison-of-clinicopathologic-characteristics-and-oncologic-outcomes-of-upper-tract-urothelial-carcinoma-in-china-and-the-united-states
#13
Nirmish Singla, Dong Fang, Xiaohong Su, Zhengqing Bao, Zhenpeng Cao, Syed M Jafri, Gengyan Xiong, Lei Zhang, Ryan Hutchinson, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Liqun Zhou, Jay D Raman, Vitaly Margulis
PURPOSE: To evaluate differences in clinicopathologic characteristics and oncologic outcomes between upper-tract urothelial carcinoma (UTUC) patients in China and the United States (U.S.). METHODS: Clinicopathologic and oncologic outcomes data of UTUC patients treated surgically at tertiary care medical facilities in the U.S. or China from 1998-2015 were retrospectively compiled. Baseline demographics, comorbidities, and pathologic features were evaluated. Oncologic endpoints including intravesical recurrence and cancer-specific survival (CSS) were obtained following exclusion of patients who received systemic chemotherapy...
November 22, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27885451/increased-nucleophosmin-expression-is-a-strong-predictor-of-recurrence-and-prognosis-in-patients-with-n0m0-upper-tract-urothelial-carcinoma-undergoing-radical-nephroureterectomy
#14
Harutake Sawazaki, Keiichi Ito, Takako Asano, Kenji Kuroda, Akinori Sato, Junichi Asakuma, Akio Horiguchi, Kenji Seguchi, Tomohiko Asano
PURPOSE: We aimed to evaluate whether increased nucleophosmin expression predicts recurrence and survival in upper tract urothelial carcinoma (UTUC). METHODS: Specimens from 101 patients with N0M0 UTUC undergoing radical nephroureterectomy were evaluated. Nucleophosmin expression was determined immunohistochemically and categorized into two groups according to nucleophosmin staining intensity. The association between nucleophosmin expression and various clinicopathological factors including Ki-67 expression was analyzed...
November 24, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27870887/epidermal-growth-factor-receptor-and-ki-67-as-predictive-biomarkers-identify-patients-who-will-be-more-sensitive-to-intravesical-instillations-for-the-prevention-of-bladder-cancer-recurrence-after-radical-nephroureterectomy
#15
Xingbo Long, Xiongbing Zu, Yuan Li, Wei He, Xiheng Hu, Shiyu Tong, Zhi Wang, Minfeng Chen, Lin Qi
BACKGROUND: To date, prophylactic intravesical chemotherapy after radical nephroureterectomy is one of the few available treatments that effectively prevent secondary bladder cancer. However, treating all patients with prophylactic intravesical chemotherapy is excessive for patients who are at a low risk or insensitive to the treatment. Thus, to guide individualized clinical treatment, in addition to identifying patients who are at risk of bladder cancer recurrence, it is equally necessary to identify the patients who will benefit the most from prophylactic, postoperative intravesical instillation therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27846934/-ccafu-french-national-guidelines-2016-2018-on-upper-tract-tumors
#16
M Rouprêt, P Colin, E Xylinas, E Compérat, F Dubosq, N Houédé, S Larré, A Masson-Lecomte, Y Neuzillet, G Pignot, P Puech, M Roumiguié, A Méjean
INTRODUCTION: The purpose was to propose an update of the french guidelines from the national committee CCAFU on upper tract urothelial carcinomas (UTUC). METHODS: A systematic Medline search was performed between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of UTUC, to evaluate different references with levels of evidence. RESULTS: The diagnosis of this rare pathology is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27830374/prognostic-role-of-expression-of-n-cadherin-in-patients-with-upper-tract-urothelial-carcinoma-a-multi-institutional-study
#17
Mohammad Abufaraj, Marco Moschini, Francesco Soria, Kilian Gust, Mehmet Özsoy, Romain Mathieu, Morgan Rouprêt, Vitaly Margulis, Jose A Karam, Christopher G Wood, Alberto Briganti, Karim Bensalah, Andrea Haitel, Shahrokh F Shariat
PURPOSE: To assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients. PATIENTS AND METHODS: Immunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The Kaplan-Meier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27785917/risk-of-intravesical-recurrence-after-ureteroscopic-biopsy-for-upper-tract-urothelial-carcinoma-does-the-location-matter
#18
Sangjun Yoo, Dalsan You, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong
INTRODUCTION: To investigate whether ureteroscopic biopsy (URS-Bx) for upper tract urothelial carcinoma (UTUC) before radical nephroureterectomy affects intravesical recurrence (IVR). PATIENTS AND METHODS: Of the 515 patients receiving radical nephroureterectomy for UTUC between 1998 and 2012, 387 patients were included for the analysis. URS-Bx was performed in 69 patients (17.8%). Patients were stratified according to tumor location, and the impact of URS-Bx on IVR was evaluated after adjusting for other clinicopathologic variables...
November 29, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27785429/predictive-models-and-prognostic-factors-for-upper-tract-urothelial-carcinoma-a-comprehensive-review-of-the-literature
#19
REVIEW
Aurélie Mbeutcha, Romain Mathieu, Morgan Rouprêt, Kilian M Gust, Alberto Briganti, Pierre I Karakiewicz, Shahrokh F Shariat
In the context of customized patient care for upper tract urothelial carcinoma (UTUC), decision-making could be facilitated by risk assessment and prediction tools. The aim of this study was to provide a critical overview of existing predictive models and to review emerging promising prognostic factors for UTUC. A literature search of articles published in English from January 2000 to June 2016 was performed using PubMed. Studies on risk group stratification models and predictive tools in UTUC were selected, together with studies on predictive factors and biomarkers associated with advanced-stage UTUC and oncological outcomes after surgery...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785428/risk-stratification-for-kidney-sparing-procedure-in-upper-tract-urothelial-carcinoma
#20
REVIEW
Zine-Eddine Khene, Romain Mathieu, Solène-Florence Kammerer-Jacquet, Thomas Seisen, Morgan Roupret, Shahrokh F Shariat, Benoit Peyronnet, Karim Bensalah
Risk stratification for kidney sparing procedures (KSP) to treat upper tract urothelial carcinoma (UTUC) is a major issue. A non-systematic Medline/PubMed literature search was performed using the terms "upper tract urothelial carcinoma" with different combinations of keywords to review the current knowledge on this topic. Original articles, reviews and editorials in English language were selected based on their clinical relevance. Available techniques for KSP include segmental ureterectomy and endoscopic resection through a percutaneous or flexible ureteroscopic access...
October 2016: Translational Andrology and Urology
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