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https://www.readbyqxmd.com/read/29650142/endoscopic-approaches-to-upper-tract-urothelial-carcinoma
#1
REVIEW
Firas G Petros, Roger Li, Surena F Matin
A select group of patients with upper tract urothelial carcinoma (UTUC) may meet indications for endoscopic management. Strategies for disease management are provided, based on a comprehensive review of the data using PubMed and Medline databases and marrying this with our experience with endoscopic management of UTUC. Endoscopic management of UTUC via retrograde or antegrade approaches is a viable treatment option for appropriately selected patients with low-risk UTUC, including those with low-grade, low-volume, and solitary tumors...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29643716/brain-metastasis-from-renal-urothelial-carcinoma-successfully-treated-by-metastasectomy
#2
Wen-Kuei Fang, Yeong-Chin Jou, Yuan-Chang Dai, Pi-Chan Ko, Ya-Fang Huang
Upper tract urothelial cancer (UTUC) arises from the urothelial lining of the urinary tract. UTUC spreads in several different ways including direct invasion, lymphatic spread, and hematogeneous metastases. Regional lymph nodes are commonly the initial site of metastasis, followed by the liver, lung, and bone. Brain metastasis is uncommon in patients with urothelial carcinoma. Here, we report an uncommon case of kidney urothelial carcinoma with brain metastasis in a 55-year-old woman presenting with dysarthria with right side limb weakness...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29599356/prognostic-value-of-albumin-globulin-ratio-in-patients-with-upper-tract-urothelial-carcinoma-patients-treated-with-radical-nephroureterectomy
#3
Hiroshi Fukushima, Masaki Kobayashi, Keizo Kawano, Shinji Morimoto
BACKGROUND/AIM: We investigated the prognostic role of the albumin/globulin ratio (AGR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). PATIENTS AND METHODS: AGR was calculated as follows: AGR=serum albumin/(serum total protein-serum albumin). Associations of preoperative AGR with disease-free (DFS) and overall (OS) survival were assessed in 105 patients with UTUC undergoing RNU. RESULTS: Patients with preoperative AGR <1...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29587736/comparison-of-clinicopathologic-characteristics-epigenetic-biomarkers-and-prognosis-between-renal-pelvic-and-ureteral-tumors-in-upper-tract-urothelial-carcinoma
#4
Dong Fang, Shiming He, Gengyan Xiong, Nirmish Singla, Zhenpeng Cao, Lei Zhang, Xuesong Li, Liqun Zhou
BACKGROUND: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis. METHODS: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared...
March 27, 2018: BMC Urology
https://www.readbyqxmd.com/read/29581871/positive-urinary-fluorescence-in-situ-hybridization-indicates-poor-prognosis-in-patients-with-upper-tract-urothelial-carcinoma
#5
Bao Guan, Yicong Du, Xiaohong Su, Zhenpeng Cao, Yifan Li, Yonghao Zhan, Ding Peng, Gengyan Xiong, Dong Fang, Yi Ding, Shiming He, Yanqing Gong, Qun He, Xuesong Li, Liqun Zhou
Here, we evaluated the potential contribution of fluorescent in situ hybridization (FISH) as a prognostic risk factor of bladder recurrence and survival in patients with upper tract urothelial carcinoma (UTUC). A total of 159 UTUC patients were enrolled in this study from January 2012 to May 2016. The 159 voided urine samples before surgery were analyzed using the UroVysion® kit to detect the copy numbers of chromosomes 3, 7, 17 and 9p21 (p16). Patients were classified using an optimal cutoff value of chromosomes 3, 7, 17, and 9p21...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29572121/prognostic-significance-of-epithelial-mesenchymal-transition-phenotypes-in-upper-urinary-tract-urothelial-carcinoma
#6
Junhun Cho, Sang Yun Ha, Seok-Hyung Kim, Hyun Hwan Sung, Ghee Young Kwon
Epithelial-mesenchymal transition (EMT) is a process which epithelial cells gain mesenchymal phenotype such as motility and invasiveness. We investigated the role of EMT in upper urinary tract urothelial carcinoma (UTUC). The patient cohort included 93 cases of UTUC treated with radical nephroureterectomy. Tissue microarrays were constructed from formalin-fixed paraffin-embedded tissue blocks. Immunohistochemical staining was performed for E-cadherin, vimentin, and smooth muscle actin to evaluate the EMT status...
February 14, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29562765/comparison-of-flexible-ureterorenoscope-quality-of-vision-an-in-vitro-study
#7
Michele Talso, Silvia Proietti, Esteban Emiliani, Andrea Gallioli, Laurian Dragos, Andrea Orosa Andrada, Pol Servián, Aarón Barreiro, Guido Giusti, Emanuele Montanari, Bhaskar K Somani, Olivier Traxer
INTRODUCTION Flexible Ureterorenoscopy (fURS) is one of the best solution for treatment of renal calculi less than 2 cm and for upper tract urinary cancer (UTUC) conservative treatment. An adequate quality of vision is mandatory to help surgeon having better outcomes. No studies have been done, to our knowledge, about what fURS on the market has the best quality of vision. Material and Methods Seven different fURS were used to compare the image quality (Lithovue, OlympusV, OlympusV2, Storz FlexXC - in White Light and in ClaraChroma mode - , Wolf Cobra Vision, Olympus P6 and Storx Flex X2)...
March 21, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29551583/prognostic-factors-and-risk-stratification-in-invasive-upper-tract-urothelial-carcinoma
#8
Hamid Emamekhoo, Puneet Dhillon, Dharmesh Gopalakrishnan, Paul Elson, Andrew Stephenson, Cristina Magi-Galluzzi, Jesse McKenney, Holly Harper, Georges-Pascal Haber, Jihad Kaouk, Byron Lee, Amr Fergany, Ryan Berglund, Michael Gong, Robert Stein, Venkatesh Krishnamurthi, Timothy Gilligan, Moshe Ornstein, Brian Rini, Jorge Garcia, Petros Grivas
BACKGROUND: Upper tract urothelial carcinoma (UTUC) accounts for approximately 5% of all urothelial cancers. Because of similarities in morphology and histology between UTUC and urothelial carcinoma of the bladder, most treatment guidelines used for UTUC are extrapolated from the urothelial bladder carcinoma setting. With the emergence of new treatment modalities, such as immunotherapy, UTUC-specific prognostic and predictive models are needed. PATIENTS AND METHODS: A retrospective study of 454 UTUC patients who received surgery at Cleveland Clinic (1995-2014) was conducted...
February 6, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29551582/ki-67-as-a-prognostic-marker-in-upper-urinary-tract-urothelial-carcinoma-a-systematic-review-and-meta-analysis
#9
Chihyun Ahn, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Hyung Suk Kim, Ja Hyeon Ku
BACKGROUND: We systematically evaluated the prognostic significance of Ki-67 on survival outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). MATERIALS AND METHODS: We searched the Embase, Scopus, and PubMed databases for all articles published up to February 2017 by following the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. The outcomes of interest included intravesical recurrence (IVR)-free survival, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS)...
February 24, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29550201/effect-of-malnutrition-on-radical-nephroureterectomy-morbidity-and-mortality-opportunity-for-preoperative-optimization
#10
Matthew Katz, Daniel A Wollin, Nicholas M Donin, William Meeks, Scott Gulig, Lee C Zhao, James S Wysock, Samir S Taneja, William C Huang, Marc A Bjurlin
INTRODUCTION: Nutritional status has been increasingly recognized as an important predictor of prognosis and surgical outcomes for cancer patients. We evaluated the effect of preoperative malnutrition on the development of surgical complications and mortality after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: Using data from the American College of Surgeons National Surgical Quality Improvement Program, we evaluated the association of poor nutritional status with 30-day postoperative complications and overall mortality after RNU from 2005 to 2015...
February 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29550096/upper-tract-urothelial-carcinoma-following-intravesical-bacillus-calmette-gu%C3%A3-rin-therapy-for-nonmuscle-invasive-bladder-cancer-results-from-a-multi-institutional-retrospective-study
#11
Naotaka Nishiyama, Hiroshi Hotta, Atsushi Takahashi, Masahiro Yanase, Naoki Itoh, Hitoshi Tachiki, Noriomi Miyao, Masanori Matsukawa, Yasuharu Kunishima, Keisuke Taguchi, Hiroshi Kitamura, Naoya Masumori
OBJECTIVES: The aim of this study was to clarify the prognostic indicators for upper tract urothelial carcinoma (UTUC) following intravesical bacillus Calmette-Guérin (BCG) therapy for nonmuscle-invasive bladder cancer (NMIBC). METHODS: Data from 402 patients who received intravesical BCG therapy between January 1990 and November 2011 were collected from 10 institutes. The median follow-up interval from transurethral resection of the bladder tumor (TURBT) followed by BCG treatment was 50...
March 14, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29548907/the-impact-of-preoperative-severe-renal-insufficiency-on-poor-postsurgical-oncological-prognosis-in-patients-with-urothelial-carcinoma
#12
Masaki Momota, Shingo Hatakeyama, Noriko Tokui, Tendo Sato, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Satoshi Narita, Toshiaki Kawaguchi, Chikara Ohyama
BACKGROUND: The impact of preoperative renal impairment severity on prognosis in urothelial carcinoma remains unelucidated. OBJECTIVE: To evaluate the impact of severe preoperative renal insufficiency on oncological outcomes in patients with urothelial carcinoma who underwent radical cystectomy or nephroureterectomy. DESIGN, SETTING, AND PARTICIPANTS: A total of 1066 patients with urothelial carcinoma who underwent radical cystectomy or nephroureterectomy at six medical centres from February 1995 to November 2017 were retrospectively examined...
March 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29534418/-application-of-narrow-band-imaging-flexible-ureteroscopy-in-the-diagnosis-treatment-and-follow-up-of-upper-tract-urothelial-carcinomas
#13
Y C Hao, C L Xiao, K Liu, Y Q Liu, L L Ma
Objective: To investigate application value of narrow-band imaging (NBI) flexible ureteroscopy in the diagnosis, treatment and follow-up of upper urinary tract transitional carcinomas (UTUC). Methods: From June 2015 to June 2017, 16 patients of UTUC were treated by flexible ureteroscopy with white light (WLI) and NBI at Department of Urology, Peking University Third Hospital , including 10 females and 6 males. The age of patients ranged from 43 to 84 years (average 68.9 years). There were 54 cases, including 16 cases with first-suspicion of cancer, and 38 cases with known of UTUC as follow-up...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29525380/prognostic-effect-of-fgfr-mutations-or-gene-fusions-in-patients-with-metastatic-urothelial-carcinoma-receiving-first-line-platinum-based-chemotherapy-results-from-a-large-single-institution-cohort
#14
Andrea Necchi, Salvatore Lo Vullo, Daniele Raggi, Annunziata Gloghini, Patrizia Giannatempo, Maurizio Colecchia, Luigi Mariani
FGFR gene alterations represent a target for treatment in clinical trials of urothelial carcinoma (UC). Little is known about their prognostic effect in patients with metastatic UC. We analyzed data for 112 patients treated with platinum-based first-line chemotherapy at our center between October 2011 and March 2017 and who were screened for the presence of FGFR mutations or gene fusions within multiple clinical trials with pan-FGFR inhibitors. Centralized targeted exome sequencing analyses were performed to detect multiple FGFR mutations and fusions...
March 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29506950/an-analysis-of-staging-and-treatment-trends-for-upper-tract-urothelial-carcinoma-in-the-national-cancer-database
#15
Brendan M Browne, Kristian D Stensland, Matthew J Moynihan, David Canes
BACKGROUND: The purpose of this study was to analyze contemporary trends for diagnosis and treatment of upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: We identified all cases of UTUC in the National Cancer Database (NCDB) between 2004 and 2013. Data comprising tumor, patient, and facility factors were extracted. Treatment data for surgery and chemotherapy were also collected. Comparisons used χ2 testing. RESULTS: Over this 10-year period, the sex and age distribution of UTUC was stable at 60% male and median age of 72 years...
February 5, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29500709/how-do-organ-specific-metastases-affect-prognosis-and-surgical-treatment-for-patients-with-metastatic-upper-tract-urothelial-carcinoma-first-evidence-from-population-based-data
#16
Fan Dong, Hangcheng Fu, Xiao Shi, Yifan Shen, Tianyuan Xu, Fengbin Gao, Xianjin Wang, Shan Zhong, Qiang Ding, Zhoujun Shen, Shanwen Chen
To evaluate the prognostic roles of organ-specific metastases and analyze the impact of organ-specific metastases on surgical resection of the primary tumor for metastatic upper tract urothelial carcinoma (UTUC) patients. A population-based study using Surveillance, Epidemiology, and End Results database was carried out. Kaplan-Meier analysis were used for survival comparisons. Multivariate Cox regression model was employed to analyze the effect of distant metastatic organs on overall survival (OS) and cancer specific survival (CSS)...
March 2, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29468284/is-neutrophil-to-lymphocytes-ratio-a-clinical-relevant-preoperative-biomarker-in-upper-tract-urothelial-carcinoma-a-meta-analysis-of-4385-patients
#17
REVIEW
Mihai Dorin Vartolomei, Shoji Kimura, Matteo Ferro, Liliana Vartolomei, Beat Foerster, Mohammad Abufaraj, Shahrokh F Shariat
BACKGROUND: Preoperative blood-based inflammatory biomarkers have been suggested to improve staging and prognostication in patients with upper-tract urothelial carcinoma (UTUC). Neutrophil-to-lymphocyte ratio (NLR) is the most studied blood-based biomarker. NLR is an indicator of systemic inflammation and has been shown to be associated with a poor prognosis in various malignancies. The aim of this study was to analyze the current evidence regarding the prognostic significance of preoperative NLR in patients undergoing radical nephroureterectomy (RNU) for UTUC to assess its prognostic potential...
February 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29463251/kidney-autotransplantation-after-nephrectomy-and-work-bench-surgery-as-an-ultimate-approach-to-nephron-sparing-surgery
#18
Martin W W Janssen, Johannes Linxweiler, Ines Philipps, Zentia Bütow, Stefan Siemer, Michael Stöckle, Carsten-Henning Ohlmann
BACKGROUND: Kidney autotransplantation (KAT) is the ultimate approach for nephron-sparing surgery. It is a rarely used method in renal tumor surgery today as minimal invasive and open techniques for nephron-sparing surgery improve constantly. In this publication, the complication rate and the long-term functional and oncological outcome at a single center are analyzed. METHODS: A prospectively constructed database of patients with renal tumors who underwent renal surgery was retrospectively analyzed to identify patients with KAT and describe surgical and oncological outcomes and to obtain long-term follow-up...
February 20, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29454319/treatment-of-upper-tract-urothelial-carcinoma-with-ureteroscopy-and-thulium-laser-a-retrospective-single-center-study
#19
Jin Wen, Zhi G Ji, Han Z Li
BACKGROUND: Treatment with the combination of ureteroscopy and thulium laser ablation may provide an alternative to radical nephroureterectomy (RNU) for patients with upper tract urothelial carcinoma (UTUC). The purpose of this study was to investigate the efficacy and safety of this technique. METHODS: We performed a retrospective review of the data for patients who were treated surgically for upper tract urothelial carcinoma in a single center. It included 32 patients treated by endoscopic thulium laser resection and 107 patients treated by radical nephroureterectomy (RNU)...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29436164/investigation-of-estimated-glomerular-filtration-rate-and-its-perioperative-change-in-patients-with-upper-urinary-tract-urothelial-carcinoma-a-multi-institutional-retrospective-study
#20
Dai Koguchi, Kazumasa Matsumoto, Masaomi Ikeda, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
AIM: To investigate the association of perioperative estimated glomerular filtration rate (eGFR) with prognosis in patients with upper urinary tract urothoelial caicinoma (UTUC). METHODS: A total of 433 patients underwent radical nephroureterectomy with excision of the bladder cuff (RNU) at six hospitals affiliated with Kitasato University in Japan. Patients were divided into three groups each in terms of preoperative eGFR: normal eGFR (>60 mL/min/1.73 m 2 ; n = 172), moderately reduced eGFR (45-60 mL/min/1...
February 12, 2018: Asia-Pacific Journal of Clinical Oncology
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