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Alfredo Sosa

Ana Calzada-Reyes, Alfredo Alvarez-Amador, Lídice Galán-García, Mitchell Valdés-Sosa
Background Few studies have investigated the impact of the psychopathic traits on the EEG of teenagers with conduct disorder (CD). To date, there is no other research studying low-resolution brain electromagnetic tomography (LORETA) technique using quantitative EEG (QEEG) analysis in adolescents with CD and psychopathic traits. Objective To find electrophysiological differences specifically related to the psychopathic traits. The current investigation compares the QEEG and the current source density measures between adolescents with CD and psychopathic traits and adolescents with CD without psychopathic traits...
June 7, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Gipsis Suárez-Román, Tammy Fernández-Romero, Alfredo J Perera-Calderín, Víctor M Rodríguez-Sosa, Celeste Arranz, Sonia Clapés Hernández
INTRODUCTION: Several epidemiologic studies in humans have shown a relationship between pregestational obesity and congenital malformations in offsprings. However, there are no experimental evidence in animal models of obesity and pregnancy that reproduce the teratogenesis induced by this pathological condition. OBJECTIVE: To evaluate the effect of monosodium glutamate-induced obesity on embryonic development. METHODS: Female rats received subcutaneously (4 mg/g body weight) monosodium glutamate (MSG) solution or saline solution 0...
September 2016: Reproductive Sciences
Ana Calzada-Reyes, Alfredo Alvarez-Amador, Lídice Galán-García, Mitchell Valdés-Sosa
No abstract text is available yet for this article.
December 2015: International Journal of Developmental Neuroscience
Alfredo Rodríguez, Leda Torres, Ulises Juárez, David Sosa, Eugenio Azpeitia, Benilde García-de Teresa, Edith Cortés, Rocío Ortíz, Ana M Salazar, Patricia Ostrosky-Wegman, Luis Mendoza, Sara Frías
BACKGROUND: The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damage, normal and FA cells inhibit the cell cycle progression, until the G2/M checkpoint is turned off by the checkpoint recovery, which becomes activated when the DNA damage has been repaired. Interestingly, highly damaged FA cells seem to override the G2/M checkpoint. In this study we explored with a Boolean network model and key experiments whether checkpoint recovery activation occurs in FA cells with extensive unrepaired DNA damage...
2015: Theoretical Biology & Medical Modelling
Juan Carlos Ramírez, Carolina Inés Cura, Otacilio da Cruz Moreira, Eliane Lages-Silva, Natalia Juiz, Elsa Velázquez, Juan David Ramírez, Anahí Alberti, Paula Pavia, María Delmans Flores-Chávez, Arturo Muñoz-Calderón, Deyanira Pérez-Morales, José Santalla, Paulo Marcos da Matta Guedes, Julie Peneau, Paula Marcet, Carlos Padilla, David Cruz-Robles, Edward Valencia, Gladys Elena Crisante, Gonzalo Greif, Inés Zulantay, Jaime Alfredo Costales, Miriam Alvarez-Martínez, Norma Edith Martínez, Rodrigo Villarroel, Sandro Villarroel, Zunilda Sánchez, Margarita Bisio, Rudy Parrado, Lúcia Maria da Cunha Galvão, Antonia Cláudia Jácome da Câmara, Bertha Espinoza, Belkisyole Alarcón de Noya, Concepción Puerta, Adelina Riarte, Patricio Diosque, Sergio Sosa-Estani, Felipe Guhl, Isabela Ribeiro, Christine Aznar, Constança Britto, Zaida Estela Yadón, Alejandro G Schijman
An international study was performed by 26 experienced PCR laboratories from 14 countries to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and quantification of parasitic loads in peripheral blood samples from Chagas disease patients. Two methods were studied: Satellite DNA (SatDNA) qPCR and kinetoplastid DNA (kDNA) qPCR. Both methods included an internal amplification control. Reportable range, analytical sensitivity, limits of detection and quantification, and precision were estimated according to international guidelines...
September 2015: Journal of Molecular Diagnostics: JMD
Pablo Colsa-Gutiérrez, Mahgol Kharazmi-Taghavi, Rocío Daniela Sosa-Medina, José Ignacio Berrío-Obregón, Alfredo Ingelmo-Setién
BACKGROUND: Ectopic gastric mucosa has been described in different locations of the digestive tract, but that of the rectum is the least frequent. CLINICAL CASE: The case is described of a 48 year-old woman being investigated by the gastrointestinal department due to rectal bleeding and rectal tenesmus. Colonoscopy showed a diverticular cavity 3 cm, which was reported by histology as fundic-type heterotopic gastric mucosa. Barium enema and abdominopelvic CT showed a diverticular image at level of the right posterolateral wall of the rectal ampulla...
March 2016: Cirugia y Cirujanos
Juan Carlos Esparza-García, David Santiago-Germán, María Guadalupe Valades-Mejía, Jesus Hernández-Juárez, Eberth Aguilar-Sosa, Alfredo Leaños-Miranda, Antonio Alvarado-Moreno, Abraham Majluf-Cruz, Irma Isordia-Salas
BACKGROUND: Polymorphisms in the endothelial nitric oxide synthase (eNOS) and in the plasminogen activator inhibitor -1 (PAI-1) genes have been implicated in stroke pathogenesis but results are still controversial. The aim of this study was to examine the possible contribution of Glu298Asp in the eNOS and 4G/5G in the PAI-1polymorphisms with ischemic stroke in a young Mexican population. MATERIALS AND METHODS: In a case-control study, conducted between January 2006 and June 2010, 204 patients ≤45 years of age with ischemic stroke and 204 controls matched by age and gender, were recruited...
September 2015: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Pablo Colsa-Gutiérrez, Mahgol Kharazmi-Taghavi, Rocío Daniela Sosa-Medina, José Manuel Gutiérrez-Cabezas, Alfredo Ingelmo-Setién
BACKGROUND: The incidence of splenic artery aneurysm is not well known because they are often asymptomatic. CLINICAL CASE: The case is presented of a 40 year-old woman diagnosed with a splenic artery aneurysm. She was clinically asymptomatic. A three-dimensional angiographic study was performed. The artery embolisation was rejected, according to the results of the study; thus it was decided to perform a laparoscopic splenic-aneurysmectomy. CONCLUSIONS: Splenic artery aneurysms may present with non-specific symptoms, such as abdominal pain or anorexia...
March 2015: Cirugia y Cirujanos
Pablo Colsa Gutiérrez, Mahgol Kharazmi Taghavi, Rocío Sosa Medina, José Manuel Gutiérrez Cabezas, Víctor Jacinto Ovejero Gómez, José Luis Ruiz, Alfredo Ingelmo Setién
INTRODUCTION: The aim of the study was to evaluate preoperative factors associated with remission of diabetes and weight loss after laparoscopic gastric band surgery. MATERIAL AND METHODS: A retrospective cohort of 95 patients who had an adjustable gastric band placed were included. A preliminary descriptive study of prognostic factors was performed using the logistic regression model with SPSS 17.0. The independent variables were age, sex, body mass index (BMI), diabetes status and degree of obesity; dependent variables were the proportion of weight loss, change in diabetes status score and percent changes in fasting sugar and glycosylated hemoglobin...
March 2015: Cirugía Española
Irma Isordia-Salas, María Eugenia Galván-Plata, Alfredo Leaños-Miranda, Eberth Aguilar-Sosa, Francisco Anaya-Gómez, Abraham Majluf-Cruz, David Santiago-Germán
BACKGROUND: Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis. AIM: To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose tolerance (NGT), prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease...
2014: Journal of Diabetes Research
Susana Aznar, Cristian Gallardo, Carmen Fiuza-Luces, Elena Santana-Sosa, Luis M López-Mojares, Alfredo Santalla, Gabriel Rodríguez-Romo, Margarita Pérez, Nuria Garatachea, Alejandro Lucia
BACKGROUND: Physical activity (PA) is recommended as part of the treatment regimen for cystic fibrosis (CF) although objective methods have been scarcely used to monitor achievement of PA guidelines. METHODS: PA was measured by accelerometer in outpatient CF children (n=47) and results were compared with those obtained in age- and gender-matched healthy controls (n=39). RESULTS: 2.1% of the outpatients fulfilled PA guidelines (i.e. ≥60min·day(-1) of moderate-to-vigorous PA (MVPA)) vs...
May 2014: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Ana Calzada-Reyes, Alfredo Alvarez-Amador, Lídice Galán-García, Mitchell Valdés-Sosa
UNLABELLED: Previous EEG studies attempted to examine violent behavior as homogeneous construct. Up to date, there is no other research studying Low-Resolution Brain Electromagnetic Tomography (LORETA) technique in psychopath offenders. OBJECTIVE: To find electrophysiological differences specifically related to the psychopathy construct and independent of the violent behavior. The current investigation compares the QEEG and the current source density measures of violent psychopath offenders to a non-psychopath violent group...
January 2013: Journal of Forensic and Legal Medicine
Joel Salazar-Flores, Luis A Torres-Reyes, Gabriela Martínez-Cortés, Rodrigo Rubi-Castellanos, Martha Sosa-Macías, José F Muñoz-Valle, César González-González, Angélica Ramírez, Raquel Román, José L Méndez, Andrés Barrera, Alfredo Torres, Rafael Medina, Héctor Rangel-Villalobos
BACKGROUND: The distribution of polymorphisms in the CYP2D6 and CYP2C19 genes allows inferring the potential risk for specific adverse drug reactions and lack of therapeutic effects in humans. This variability shows differences among human populations. The aim of this study was to analyze single-nucleotide polymorphisms related to a poor metabolizer (PM) phenotype in nonpreviously studied Amerindian groups and Mestizos (general admixed population) from Mexico. METHODS: We detected by SNaPshot(®) different polymorphisms located in CYP2D6 (*3, *4, *6, *7, and *8) and CYP2C19 (*2, *3, *4 and *5) in western Mestizos (n=145) and five Amerindian groups from Mexico: Tarahumaras from the North (n=88); Purépechas from the Center (n=101); and Tojolabales (n=68), Tzotziles (n=88), and Tzeltales (n=20) from the Southeast...
September 2012: Genetic Testing and Molecular Biomarkers
Paulo Sávio Angeiras de Goes, Nilcema Figueiredo, Jerlucia Cavalcanti das Neves, Fabiana Moura da Motta Silveira, José Felipe Riani Costa, Gilberto Alfredo Pucca Júnior, Maritza Sosa Rosales
This article discusses the evaluation of secondary care in the area of health surveillance. This was a descriptive and normative/evaluative study. Performance analysis drew on secondary data, based on a historical series of dental procedures conducted at the specialized dental clinics implemented in Brazil and recorded by the Outpatient Information System of the Unified National Health System (SIA/SUS) in 2007, as well as primary data from site visits to the clinics, based on questionnaires completed by clinic staff...
2012: Cadernos de Saúde Pública
Alfredo Rodríguez, David Sosa, Leda Torres, Bertha Molina, Sara Frías, Luis Mendoza
MOTIVATION: Fanconi anemia (FA) is a chromosomal instability syndrome originated by inherited mutations that impair the Fanconi Anemia/Breast Cancer (FA/BRCA) pathway, which is committed to the repair of DNA interstrand cross-links (ICLs). The disease displays increased spontaneous chromosomal aberrations and hypersensitivity to agents that create DNA interstrand cross-links. In spite of DNA damage, FA/BRCA-deficient cells are able to progress throughout the cell cycle, probably due to the activity of alternative DNA repair pathways, or due to defects in the checkpoints that monitor DNA integrity...
March 15, 2012: Bioinformatics
Ana Calzada-Reyes, Alfredo Alvarez-Amador, Lídice Galán-García, Mitchell Valdés-Sosa
The presence of brain dysfunction in violent offenders has been frequently examined with inconsistent results. The aim of the study was to assess the EEG of 84 violent offenders by visual inspection and frequency-domain quantitative analysis in 84 violent prisoners. Low-resolution electromagnetic tomography (LORETA) was also employed for theta band of the EEG spectra. Antisocial personality disorder (ASPD) was present in 50 of the offenders and it was absent in the remaining 34. The prevalence of EEG abnormalities, by visual inspection, was similar for both the ASPD group (82%) and non-ASPD group (79%)...
January 2012: Journal of Forensic and Legal Medicine
José Luis Beristain Hernández, Erick Servín Torres, Alejandro Sosa Caballero, José Arturo Velázquez García, Roger Pozzo Bobarín, Germán Delgadillo Teyer, Ignacio Serrano Galeana, Alfredo Márquez Hernández, Francisco Bevia Pérez, Marco Antonio Piscil Salazar, Daniel Ortiz De La Peña Salazar Ilarregui, Francisco Javier Sánchez González, Amilcar Espinoza Aguilar
BACKGROUND: 99mTc sestamibi scanning and aspiration biopsy can predict the histopathological result of a thyroid nodule fairly accurately. OBJECTIVE: To determine the accuracy of 99mTc sestamibi scanning in detecting malignancy in patients with thyroid nodule confirmed by definitive histopathological report after thyroidectomy. MATERIAL AND METHODS: A total of 69 patients with a solitary thyroid nodule were studied. In all patients, fine needle aspiration, total thyroidectomy for suspected thyroid cancer, and histological analysis of the surgical specimen were performed...
December 2010: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Sebastián Dupraz, Diego Grassi, María Eugenia Bernis, Lucas Sosa, Mariano Bisbal, Laura Gastaldi, Ignacio Jausoro, Alfredo Cáceres, Karl H Pfenninger, Santiago Quiroga
Axonal elongation is one of the hallmarks of neuronal polarization. This phenomenon requires axonal membrane growth by exocytosis of plasmalemmal precursor vesicles (PPVs) at the nerve growth cone, a process regulated by IGF-1 activation of the PI3K (phosphatidylinositol-3 kinase) pathway. Few details are known, however, about the targeting mechanisms for PPVs. Here, we show, in cultured hippocampal pyramidal neurons and growth cones isolated from fetal rat brain, that IGF-1 activates the GTP-binding protein TC10, which triggers translocation to the plasma membrane of the exocyst component exo70 in the distal axon and growth cone...
October 21, 2009: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Cinthya E Díaz-Benítez, Karla R Navarro-Fuentes, Jacqueline A Flores-Sosa, Janet Juárez-Díaz, Felipe J Uribe-Salas, Edgar Román-Basaure, Ludwig E González-Mena, Patricia Alonso de Ruíz, Guillermina López-Estrada, Alfredo Lagunas-Martínez, Victor H Bermúdez-Morales, Juan M Alcocer-González, Jesús Martínez-Barnetche, Rogelio Hernández-Pando, Yvonne Rosenstein, José Moreno, Vicente Madrid-Marina
INTRODUCTION: Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3zeta expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC). RESULTS AND DISCUSSION: T cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-gamma were observed in women with CC...
July 2009: Journal of Clinical Immunology
Juan Pablo Saucedo-Vázquez, Víctor Manuel Ugalde-Saldívar, Alfredo Rubén Toscano, Peter M H Kroneck, Martha Elena Sosa-Torres
Kinetic and structural data are presented for the iron-promoted dehydrogenation of the amine, [Fe(III)L3]3+ (1), L3 = 1,9-bis(2'-pyridyl)-5-[(ethoxy-2''-pyridyl)methyl]-2,5,8-triazanonane. Spectroscopic and electrochemical experiments under the exclusion of dioxygen helped to identify reaction intermediates and the final product, the Fe(II)-monoimine complex [Fe(II)L4]2+ (2), L4 = 1,9-bis(2'-pyridyl)-5-[(ethoxy-2''-pyridyl)methyl]-2,5,8-triazanon-1-ene. 2 is formed by disproportionation of the starting complex 1 by a three-step reaction mechanism, most likely via ligand-centered radical intermediates...
February 2, 2009: Inorganic Chemistry
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