Kelly Jin, Brianah M McCoy, Elisabeth A Goldman, Viktoria Usova, Victor Tkachev, Alex D Chitsazan, Anneke Kakebeen, Unity Jeffery, Kate E Creevy, Andrea Wills, Noah Snyder-Mackler, Daniel E L Promislow
Across mammals, the epigenome is highly predictive of chronological age. These "epigenetic clocks," most of which have been built using DNA methylation (DNAm) profiles, have gained traction as biomarkers of aging and organismal health. While the ability of DNAm to predict chronological age has been repeatedly demonstrated, the ability of other epigenetic features to predict age remains unclear. Here, we use two types of epigenetic information-DNAm, and chromatin accessibility as measured by ATAC-seq-to develop age predictors in peripheral blood mononuclear cells sampled from a population of domesticated dogs...
January 23, 2024: Aging Cell