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Guangzhou Biobank Cohort Study

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https://www.readbyqxmd.com/read/28477424/adiposity-and-incident-diabetes-within-4%C3%A2-years-of-follow-up-the-guangzhou-biobank-cohort-study
#1
L Xu, T H Lam, C Q Jiang, W S Zhang, Y L Jin, T Zhu, F Zhu, G N Thomas, K K Cheng
AIM: Whether different adiposity measures predict incident diabetes differentially in general Chinese populations is unclear. We investigated this in Chinese people aged 50+ years in the Guangzhou Biobank Cohort Study. METHODS: Waist circumference and BMI were measured at baseline, and fasting glucose was measured at both baseline and follow-up examinations. Incident diabetes was defined as fasting glucose ≥ 7.0 mmol/l, glucose after 2-h oral glucose tolerance test ≥ 11...
May 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28011924/childhood-secondhand-smoke-exposure-and-pregnancy-loss-in-never-smokers-the-guangzhou-biobank-cohort-study
#2
Shanshan Yang, Lin Xu, Yao He, Chaoqiang Jiang, Yali Jin, Kar Keung Cheng, Weisen Zhang, Tai Hing Lam
OBJECTIVE: Studies of secondhand smoke (SHS) exposure especially childhood SHS exposure and pregnancy loss are limited. We used baseline data of the Guangzhou Biobank Cohort Study (GBCS) to examine the association of childhood SHS exposure with a history of pregnancy loss. METHODS: Never smoking women aged 50 years or above in GBCS from 2003 to 2008 were included. Propensity score matching (PSM) was used to control for confounding. Negative binomial regression and logistic regression were used to examine the association of childhood SHS, assessed by number of smokers in childhood household and frequency of exposure, with past pregnancy loss...
December 23, 2016: Tobacco Control
https://www.readbyqxmd.com/read/28007909/mendelian-randomization-estimates-of-alanine-aminotransferase-with-cardiovascular-disease-guangzhou-biobank-cohort-study
#3
Lin Xu, Chao Qiang Jiang, Tai Hing Lam, Wei Sen Zhang, Feng Zhu, Ya Li Jin, G Neil Thomas, Kar Keung Cheng, C Mary Schooling
Observational studies of the association of alanine aminotransferase (ALT) levels with ischaemic heart disease (IHD) and cardiovascular disease (CVD) risk factors are inconsistent, probably because of confounding and reverse causality. Mendelian randomization (MR) provides less confounded results. We used MR analysis to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors. We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS)...
January 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27923538/liver-enzymes-as-mediators-of-association-between-obesity-and-diabetes-the-guangzhou-biobank-cohort-study
#4
Lin Xu, Chao Qiang Jiang, Catherine Mary Schooling, Wei Sen Zhang, Kar Keung Cheng, Tai Hing Lam
PURPOSE: To assess the proportion of the association between obesity and diabetes mediated by liver enzymes such as gamma-glutamyltransferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST). METHODS: Mediation analysis was used with adjustment for age, education, physical activity, smoking, and alcohol use. RESULTS: A total of 9748 participants from Phase III of the Guangzhou Biobank Cohort Study were recruited in 2006-2008...
November 20, 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27916142/alcohol-sensitivity-alcohol-use-and-high-sensitivity-c-reactive-protein-in-older-chinese-men-the-guangzhou-biobank-cohort-study
#5
Shao Jun Xu, Chao Qiang Jiang, Wei Sen Zhang, Kar Keung Cheng, Catherine Mary Schooling, Lin Xu, Bin Liu, Ya Li Jin, Kin Bong Hubert Lam, Tai Hing Lam
Compared to other ethnic groups Asians are more likely to be sensitive to alcohol, due to polymorphisms of alcohol-metabolizing enzymes. Although previous studies have found positive association between regular alcohol use and high-sensitivity C-reactive protein (HsCRP), whether this association is modified by alcohol sensitivity has not been clarified. We therefore sought to examined this potential effect modification in a cross-sectional community sample with high prevalence of alcohol sensitivity, using data from 2903 men aged ≥50years recruited during phase 1 of the Guangzhou Biobank Cohort Study...
December 2016: Alcohol
https://www.readbyqxmd.com/read/27770029/exposure-to-secondhand-smoke-and-risk-of-peripheral-arterial-disease-in-southern-chinese-non-smokers-the-guangzhou-biobank-cohort-study-cardiovascular-disease-sub-cohort
#6
Liya Lu, Chaoqiang Jiang, Danny F Mackay, Jill P Pell, Kar Keung Cheng, Tai Hing Lam, G Neil Thomas
Objectives We studied the association between secondhand smoke (SHS) exposure and peripheral arterial disease (PAD) in Chinese non-smokers. Methods We conducted a cross-sectional study using baseline data from the Guangzhou Biobank Cohort Study: Cardiovascular Disease Sub-cohort Study (GBCS-CVD). Guangzhou residents aged ≥ 50 years were recruited between 2003 and 2008. Baseline data included measurement of ankle brachial pressure index (ABPI) and self-reported smoking status and SHS exposure. Univariate and multivariate logistic regression analyses were used to analyze the association between SHS and PAD (defined as ABPI < 0...
June 2017: Vascular
https://www.readbyqxmd.com/read/27765122/-correlation-between-body-fat-percentage-and-general-obesity-indexes-in-middle-aged-and-old-people-in-guangzhou
#7
Q Hu, C Q Jiang, W S Zhang, J J Cheng, L Xu, Y L Jin, S L Rao, H Q Zheng, D Q Lam
Objective: To examine the correlation between body fat percentage (BFP) and general obesity indexes, including body mass index (BMI), waist circumference (WC) and waist to hip ratio (WHR) and calculate the corresponding BFP cutoff values in the middle aged and old people in Guangzhou. The corresponding cut-point of optimal body fat percentage for Guangzhou older population. Methods: Based on the Guangzhou Biobank Cohort Study (GBCS), 3 490 relatively healthy Guangzhou residents aged ≥50 years were selected and were randomly divided into 2 groups...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27502758/environment-wide-association-study-to-identify-factors-associated-with-hematocrit-evidence-from-the-guangzhou-biobank-cohort-study
#8
Yi Zhong, Chaoqiang Jiang, Kar Keung Cheng, Weisen Zhang, Yali Jin, Tai Hing Lam, Jean Woo, Gabriel Matthew Leung, C Mary Schooling
PURPOSE: In randomized controlled trials reducing high hematocrit (Hct) in patients with polycythemia vera protects against cardiovascular disease (CVD) events, whereas increasing Hct in anemia patients causes CVD events. Hct is influenced by environmental and lifestyle factors. Given limited knowledge concerning the drivers of Hct, we took an agnostic approach to identify drivers of Hct. METHODS: We used an environment-wide association study to identify environmental and lifestyle factors associated with Hct in 20443 older Chinese adults (mean age = 62...
September 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27474097/re-evaluation-of-moderate-alcohol-use-with-qt-interval-and-heart-rate-using-mendelian-randomization-analysis-among-older-southern-chinese-men-in-the-guangzhou-biobank-cohort-study
#9
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27338881/smoking-and-serum-vitamin-d-in-older-chinese-people-cross-sectional-analysis-based-on-the-guangzhou-biobank-cohort-study
#10
C Q Jiang, Y H Chan, L Xu, Y L Jin, T Zhu, W S Zhang, K K Cheng, T H Lam
OBJECTIVE: Studies on serum vitamin D in smokers showed conflicting results. We examined the association of smoking status with serum vitamin D in older Chinese men, taking advantage of a community-based sample with natural exposure to vitamin D. DESIGN: Cross-sectional study based on the Guangzhou Biobank Cohort Study (GBCS). SETTING: Community-based sample from the Guangzhou Biobank Cohort Study. PARTICIPANTS: 612 male participants aged 50+years recruited from 2009 to 2011...
2016: BMJ Open
https://www.readbyqxmd.com/read/27036929/genetically-predicted-17beta-estradiol-cognitive-function-and-depressive-symptoms-in-women-a-mendelian-randomization-in-the-guangzhou-biobank-cohort-study
#11
Shiu Lun Au Yeung, Chaoqiang Jiang, Kar Keung Cheng, Weisen Zhang, Tai Hing Lam, Gabriel Matthew Leung, C Mary Schooling
OBJECTIVE: The role of estrogen in cognitive function and depressive symptoms is controversial due to discrepancies between results from randomized controlled trials (RCT) and observational studies. Mendelian randomization analysis may provide further insights concerning the role of estrogen in these outcomes as it assesses the effect of lifelong endogenous exposure but is less vulnerable to confounding than observational studies. METHOD: We used separate sample instrumental variable analysis to estimate the association of log 17β estradiol with cognitive function (Delayed 10 word recall, and Mini Mental State Examination (MMSE)) and depressive symptoms (Geriatric Depression Scale (GDS)) in older Chinese women of the Guangzhou Biobank Cohort Study (GBCS, n=3086)...
July 2016: Preventive Medicine
https://www.readbyqxmd.com/read/26907540/genetically-predicted-17beta-estradiol-and-cardiovascular-risk-factors-in-women-a-mendelian-randomization-analysis-using-young-women-in-hong-kong-and-older-women-in-the-guangzhou-biobank-cohort-study
#12
Shiu Lun Au Yeung, Kar Keung Cheng, Jie Zhao, Weisen Zhang, Chaoqiang Jiang, Tai Hing Lam, Gabriel Matthew Leung, C Mary Schooling
PURPOSE: The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS: We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092)...
March 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/26864717/a-mendelian-randomization-study-of-testosterone-and-cognition-in-men
#13
Jie V Zhao, Tai Hing Lam, Chaoqiang Jiang, Stacey S Cherny, Bin Liu, Kar Keung Cheng, Weisen Zhang, Gabriel M Leung, C Mary Schooling
Testosterone replacement for older men is increasingly common, with some observations suggesting a protective effect on cognitive function. We examined the association of endogenous testosterone with cognitive function among older men in a Mendelian randomization study using a separate-sample instrumental variable (SSIV) analysis estimator to minimize confounding and reverse causality. A genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong, based on selected testosterone-related single nucleotide polymorphisms (rs10046, rs1008805 and rs1256031)...
February 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26520902/the-association-of-pulmonary-function-with-carotid-atherosclerosis-in-older-chinese-guangzhou-biobank-cohort-study-cvd-subcohort
#14
MULTICENTER STUDY
Jing Pan, Lin Xu, Shao Xi Cai, Chao Qiang Jiang, Kar Keung Cheng, Hai Jin Zhao, Wei Sen Zhang, Ya Li Jin, Jie Ming Lin, G Neil Thomas, Tai Hing Lam
BACKGROUND: Evidence describing the association between pulmonary function and carotid atherosclerosis has been inconclusive and the role of smoking in this association is unclear. We therefore examined this association in the Guangzhou Biobank Cohort Study-CVD Subcohort. METHODS: Common carotid artery (CCA) intima-media thickness (IMT) and carotid plaques were measured by B-mode ultrasonography and lung function by spirometry using a turbine flowmeter. Chronic obstructive pulmonary disease (COPD) was defined as the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) of less than 0...
December 2015: Atherosclerosis
https://www.readbyqxmd.com/read/26452069/stress-across-the-life-course-and-depression-in-a-rapidly-developing-population-the-guangzhou-biobank-cohort-study
#15
Michael Y Ni, Chaoqiang Jiang, Kar Keung Cheng, Weisen Zhang, Stephen E Gilman, Tai Hing Lam, Gabriel M Leung, C Mary Schooling
OBJECTIVE: The objective of this study was to examine the role of stress across the life course in the development of depression among older adults in a non-Western developing setting. METHODS: Multivariable linear and multinomial logistic regression were used in cross-sectional analyses of 9729 Chinese participants (mean age 60.2 years) from phase 3 of the Guangzhou Biobank Cohort Study (2006-2008) to investigate the association of childhood adversities and adulthood stressors with depression...
June 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26372789/liver-enzymes-and-incident-diabetes-in-china-a-prospective-analysis-of-10%C3%A2-764-participants-in-the-guangzhou-biobank-cohort-study
#16
COMMENT
S Goya Wannamethee
No abstract text is available yet for this article.
November 2015: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/26356841/alcohol-use-and-gamma-glutamyltransferase-using-a-mendelian-randomization-design-in-the-guangzhou-biobank-cohort-study
#17
Lin Xu, Chao Qiang Jiang, Kar Keung Cheng, Shiu Lun Ryan Au Yeung, Wei Sen Zhang, Tai Hing Lam, Catherine Mary Schooling
BACKGROUND: Observational studies and small intervention studies suggest alcohol raises gamma-glutamyltransferase (GGT). We used Mendelian randomization to assess the causal effect of alcohol use on GGT in older Chinese people. METHODS: An instrumental variable (IV) analysis in 2,321 men and 2,757 women aged 50+ years from phase 3 of the Guangzhou Biobank Cohort Study with ALDH2 (rs671) genotyped, alcohol use and GGT available was used to assess the causal effect of alcohol use on GGT...
2015: PloS One
https://www.readbyqxmd.com/read/26332759/nut-consumption-and-cardiovascular-risk-in-older-chinese-the-guangzhou-biobank-cohort-study
#18
Yangbo Sun, Chao Qiang Jiang, Kar Keung Cheng, Wei Sen Zhang, Gabriel M Leung, Tai Hing Lam, C Mary Schooling
OBJECTIVES: In Western contexts nut consumption is associated with better health. We examined the associations of nut consumption with cardiovascular disease risk in the non-Western setting of Southern China. METHODS: In the Guangzhou Biobank Cohort Study we used multivariable linear regression to examine the associations of baseline nut (mainly peanuts) consumption (none (n = 6688), <3 portions/week (n = 2596) and ≥3 portions/week (n = 2444)) with follow-up assessment of Framingham cardiovascular disease score (excluding smoking) and its components in older Chinese (≥50 years) (follow-up 57...
2015: PloS One
https://www.readbyqxmd.com/read/26258947/fruit-and-vegetable-consumption-and-cardiovascular-risk-factors-in-older-chinese-the-guangzhou-biobank-cohort-study
#19
Yangbo Sun, Chao Qiang Jiang, Kar Keung Cheng, Wei Sen Zhang, Gabriel M Leung, Tai Hing Lam, C Mary Schooling
OBJECTIVE: To examine the adjusted associations of fruit consumption and vegetable consumption with the Framingham score and its components in the non-Western setting of Southern China, considering health status. METHOD: Linear regression was used to assess the cross-sectional associations of fruit and vegetable consumption with the Framingham score and its components, among 19,518 older Chinese (≥50 years) from the Guangzhou Biobank Cohort Study in Southern China (2003-2006), and whether these differed by health status...
2015: PloS One
https://www.readbyqxmd.com/read/26186646/childhood-passive-smoking-exposure-and-age-at-menarche-in-chinese-women-who-had-never-smoked-the-guangzhou-biobank-cohort-study
#20
Shanshan Yang, Yali Jin, Yao He, Chaoqiang Jiang, Kar Keung Cheng, Weisen Zhang, Tai Hing Lam
OBJECTIVE: We examined the associations between childhood passive smoking exposure and age at menarche in women who had never smoked in southern China. METHODS: Among 30,518 participants in Guangzhou Biobank Cohort Study (GBCS) from 2003-2008, 20,061 women who had never smoked and had complete outcome data were included. Childhood passive smoking exposure was defined as living with 1 or more smokers in the same household during childhood. Data on the number of smokers in the household and frequency of exposure (density and frequency) were also obtained...
2015: PloS One
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