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Pulsed radiofrequency

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https://www.readbyqxmd.com/read/28811965/adjuvant-immunotherapy-with-autologous-dendritic-cells-for-hepatocellular-carcinoma-randomized-phase-ii-study
#1
Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Yong-Soo Bae, Yoon Jun Kim
Our previous phase I/IIA study showed that autologous dendritic cells (DCs) pulsed with tumor-associated antigens are well tolerated in patients with hepatocellular carcinoma (HCC). In this randomized, multicenter, open-label, phase II trial, we investigated the efficacy and safety of this DC-based adjuvant immunotherapy with 156 patients, who treated for HCC with no evidence of residual tumor after standard treatment modalities. Patients were randomly assigned to immunotherapy (n = 77; injection of 3 × 10(7) DC cells, six times over 14 weeks) or control (n = 79; no treatment)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28807449/non-invasive-intra-cardiac-pressure-measurements-using-subharmonic-aided-pressure-estimation-proof-of-concept-in-humans
#2
Jaydev K Dave, Sushmita V Kulkarni, Purva P Pangaonkar, Maria Stanczak, Maureen E McDonald, Ira S Cohen, Praveen Mehrotra, Michael P Savage, Paul Walinsky, Nicholas J Ruggiero, David L Fischman, David Ogilby, Carolyn VanWhy, Matthew Lombardi, Flemming Forsberg
This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28806322/reduced-field-of-view-diffusion-weighted-magnetic-resonance-imaging-of-the-prostate-at-3-tesla-comparison-with-standard-echo-planar-imaging-technique-for-image-quality-and-tumor-assessment
#3
Tsutomu Tamada, Justin M Ream, Ankur M Doshi, Samir S Taneja, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study was to compare image quality and tumor assessment at prostate magnetic resonance imaging (MRI) between reduced field-of-view diffusion-weighted imaging (rFOV-DWI) and standard DWI (st-DWI). METHODS: A total of 49 patients undergoing prostate MRI and MRI/ultrasound fusion-targeted biopsy were included. Examinations included st-DWI (field of view [FOV], 200 × 200 mm) and rFOV-DWI (FOV, 140 × 64 mm) using a 2-dimensional (2D) spatially-selective radiofrequency pulse and parallel transmission...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28802550/mr-coagulation-a-novel-minimally-invasive-approach-to-aneurysm-repair
#4
Ouri Cohen, Ming Zhao, Erez Nevo, Jerome L Ackerman
PURPOSE: To demonstrate a proof of concept of magnetic resonance (MR) coagulation, in which MR imaging scanner-induced radiofrequency (RF) heating at the end of an intracatheter long wire heats and coagulates a protein solution to effect a vascular repair by embolization. MATERIALS AND METHODS: MR coagulation was simulated by finite-element modeling of electromagnetic fields and specific absorption rate (SAR) in a phantom. A glass phantom consisting of a spherical cavity joined to the side of a tube was incorporated into a flow system to simulate an aneurysm and flowing blood with velocities of 0-1...
August 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28799210/whole-brain-arteriography-and-venography-using-improved-velocity-selective-saturation-pulse-trains
#5
Wenbo Li, Feng Xu, Michael Schär, Jing Liu, Taehoon Shin, Yansong Zhao, Peter C M van Zijl, Bruce A Wasserman, Ye Qiao, Qin Qin
PURPOSE: To develop velocity-selective (VS) MR angiography (MRA) protocols for arteriography and venography with whole-brain coverage. METHODS: Tissue suppression using velocity-selective saturation (VSS) pulse trains is sensitive to radiofrequency field (B1 +) inhomogeneity. To reduce its sensitivity, we replaced the low-flip-angle hard pulses in the VSS pulse train with optimal composite (OCP) pulses. Additionally, new pulse sequences for arteriography and venography were developed by placing spatially selective inversion pulses with a delay to null signals from either venous or arterial blood...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28795984/electrophoto-biomodulation-in-aesthetic-treatment-of-postburn-hypopigmentation-clinical-response-in-relation-to-histopathological-changes
#6
Nader Elmelegy, Dalia Mohamed Mofreh El Sakka
BACKGROUND: Hypopigmentation is a troublesome often-permanent sequelae after burn injury, particularly in dark races. A number of methods have been described to treat this phenomenon. In this work, we are going to study the effect of E light (intensive pulsed light+radiofrequency+cooling) in repigmentation of partial thickness and full thickness burn wounds in adult patients and light microscopic changes of biopsy material at various stages of repigmentation. PATIENTS AND METHODS: In this study, 24 patients with postburn hypopigmentation were selected and E light was used, using different filters, according to the skin color...
September 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28792646/clinical-applications-of-chemical-exchange-saturation-transfer-cest-mri
#7
Kyle M Jones, Alyssa C Pollard, Mark D Pagel
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym ) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development...
August 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28791989/treatment-of-resistant-idiopathic-hiccups-with-pulse-radio-frequency-on-phrenic-nerve-and-gabapentin-a-case-report
#8
O Ozturk, E Yavuz, B Yazicioglu, B Uzuner
Hiccups affect life quality, career and family life when they become persistent. We present here a 54-year-old man who worked as a mason and a blacksmith with hiccups complaint for nearly one and a half years. In this period, he was admitted to emergency service ten times with fainting or almost fainting, cold sweating and hand stretching complaints. The patient expressed that he frequently threw up when he had hiccups and his social life was negatively affected. He reported that he was treated with baclofen, esomeprazole and hyoscine-n-butyl bromur without relief...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28783160/measurement-of-the-spin-temperature-of-optically-cooled-nuclei-and-gaas-hyperfine-constants-in-gaas-algaas-quantum-dots
#9
E A Chekhovich, A Ulhaq, E Zallo, F Ding, O G Schmidt, M S Skolnick
Deep cooling of electron and nuclear spins is equivalent to achieving polarization degrees close to 100% and is a key requirement in solid-state quantum information technologies. While polarization of individual nuclear spins in diamond and SiC (ref. ) reaches 99% and beyond, it has been limited to 50-65% for the nuclei in quantum dots. Theoretical models have attributed this limit to formation of coherent 'dark' nuclear spin states but experimental verification is lacking, especially due to the poor accuracy of polarization degree measurements...
August 7, 2017: Nature Materials
https://www.readbyqxmd.com/read/28782173/silent-navigator-triggered-silent-mri-of-the-abdomen
#10
Yuji Iwadate, Atsushi Nozaki, Yoshinobu Nunokawa, Shigeo Okuda, Masahiro Jinzaki, Hiroyuki Kabasawa
PURPOSE: To develop and demonstrate the feasibility of a silent respiratory navigator technique for prospective triggering, which was incorporated into a three-dimensional radial zero-echo-time sequence for respiratory navigated silent abdominal imaging. METHODS: A nonselective hard excitation radiofrequency pulse was used for the navigator sequence with a derated readout gradient, to avoid generation of high levels of acoustic noise. The acquired navigator signals were processed in real time and used for prospective triggering of the zero-echo-time sequence...
August 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28771792/diaphragm-position-can-be-accurately-estimated-from-the-scattering-of-a-parallel-transmit-rf-coil-at-7-t
#11
Aaron T Hess, Elizabeth M Tunnicliffe, Christopher T Rodgers, Matthew D Robson
PURPOSE: To evaluate the use of radiofrequency scattering of a parallel transmit coil to track diaphragm motion. METHODS: Measurements made during radiofrequency excitation on an 8-channel parallel transmit coil by the directional couplers of the radiofrequency safety monitor were combined and converted into diaphragm position. A 30-s subject-specific calibration with an MRI navigator was used to determine a diaphragm estimate from each directional-coupler measure...
August 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28768538/pulsed-radiofrequency-or-anterior-neurectomy-for-anterior-cutaneous-nerve-entrapment-syndrome-acnes-the-pulse-trial-study-protocol-of-a-randomized-controlled-trial
#12
Robbert C Maatman, Monique A H Steegers, Oliver B A Boelens, Toine C Lim, Hans J van den Berg, Sandra A S van den Heuvel, Marc R M Scheltinga, Rudi M H Roumen
BACKGROUND: Some patients with chronic abdominal pain suffer from an anterior cutaneous nerve entrapment syndrome (ACNES). This somewhat illusive syndrome is thought to be caused by the entrapment of end branches of the intercostal nerves residing in the abdominal wall. If ACNES is suspected, a local injection of an anesthetic agent may offer relief. If pain is recurrent following multiple-injection therapy, an anterior neurectomy entailing removal of the entrapped nerve endings may be considered...
August 2, 2017: Trials
https://www.readbyqxmd.com/read/28761432/effects-of-pulsed-radiofrequency-on-spasticity-in-patients-with-spinal-cord-injury-a-report-of-two-cases
#13
Min Cheol Chang, Yun Woo Cho
Spasticity following spinal cord injury (SCI) results in functional deterioration and reduced quality of life. Herein, we report two SCI patients who presented with good response to pulsed radiofrequency (PRF) for the management of spasticity in the lower extremities. Patient 1 (a 47-year-old man) had complete thoracic cord injury and showed a phasic spasticity on the extensor of both knees (3-4 beats clonus per every 30 seconds) and tonic spasticity (Modified Ashworth Scale: 3) on both hip adductors. Patient 2 (a 64-year-old man) had incomplete cervical cord injury and showed a right ankle clonus (approximately 20 beats) when he walked...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28759949/is-saphenous-nerve-radio-frequency-an-effective-treatment-for-advanced-gonarthrosis-in-elders-with-cardiac-comorbidity
#14
Pınar Karaca Baysal, Özgür Baysal, Atakan Erkılınç, Mustafa Emre Gürcü, Ayşe Nur Yeksan, Birzat Emre Gölboyu, Mürsel Ekinci
BACKGROUND: Pulsed radiofrequency (PRF) used for knee pain originating from osteoarthritis is one of these methods. OBJECTIVES: The aim of the study was to evaluate the knee functional status and pain palliation following the application of pulse radiofrequency in patients with cardiac comorbid disease who were diagnosed with advanced stage osteoarthritis. METHODS: Thirty-eight patients with high surgical risk having cardiac comorbidities with grade 3-4 gonarthrosis according to the Kellgren-Lawrence classification were retrospectively analyzed...
July 14, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28747522/pet-imaging-stability-measurements-during-simultaneous-pulsing-of-aggressive-mr-sequences-on-the-ge-signa-pet-mr
#15
Timothy W Deller, Mohammad Mehdi Khalighi, Floris P Jansen, Gary H Glover
The recent introduction of simultaneous whole-body PET/MR scanners has enabled new research taking advantage of the complementary information obtainable with PET and MR imaging. One such application is kinetic modeling, which requires high levels of PET quantitative stability. This challenges the task of isolating the two imaging subsystems from mutual interference. Performance measurements have previously been published demonstrating sufficient PET stability in the presence of MR pulsing for typical clinical use; however, PET stability during radiofrequency (RF)-intensive and gradient-intensive sequences has not previously been evaluated for a clinical whole-body scanner...
July 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28736982/understanding-the-influence-of-flow-velocity-wall-motion-filter-pulse-repetition-frequency-and-aliasing-on-power-doppler-image-quantification
#16
Maricy R Martins, Wellington P Martins, Carlos A M Soares, Andre H Miyague, Marek J Kudla, Theo Z Pavan
OBJECTIVES: Although power Doppler imaging has been used to quantify tissue and organ vascularity, many studies showed that limitations in defining adequate ultrasound machine settings and attenuation make such measurements complex to be achieved. However, most of these studies were conducted by using the output of proprietary software, such as Virtual Organ computer-aided analysis (GE Healthcare, Kretz, Zipf, Austria); therefore, many conclusions may not be generalizable because of unknown settings and parameters used by the software...
July 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28736949/simultaneous-measurement-of-brain-perfusion-and-labeling-efficiency-in-a-single-pseudo-continuous-arterial-spin-labeling-scan
#17
Zhensen Chen, Xihai Zhao, Xingxing Zhang, Rui Guo, Wouter M Teeuwisse, Bida Zhang, Peter Koken, Jouke Smink, Chun Yuan, Matthias J P van Osch
PURPOSE: The aim of this study was to propose, optimize, and validate a pseudo-continuous arterial spin labeling (pCASL) sequence for simultaneous measurement of brain perfusion and labeling efficiency. METHODS: The proposed sequence incorporates the labeling efficiency measurement into the postlabeling delay period of a conventional perfusion pCASL sequence by using the time-encoding approach. In vivo validation experiments were performed on nine young subjects by comparing it to separate perfusion and labeling efficiency sequences...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28721494/a-comprehensive-characterization-of-parameters-affecting-high-frequency-irreversible-electroporation-lesions
#18
Tyler Miklovic, Eduardo L Latouche, Matthew R DeWitt, Rafael V Davalos, Michael B Sano
Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. A series of short electric pulses create nanoscale defects in the cell membrane, eventually leading to cell death. Typical IRE protocols deliver a series of 50-100 µs monopolar pulses...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28717987/interventions-for-refractory-trigeminal-neuralgia-a-bayesian-mixed-treatment-comparison-network-meta-analysis-of-randomized-controlled-clinical-trials
#19
Kannan Sridharan, Gowri Sivaramakrishnan
INTRODUCTION: Patients with trigeminal neuralgia (TN) are often refractory to recommended first-line agents. Due to the absence of a systematic review, we undertook a network meta-analysis to assess various interventions that can be used to manage refractory TN. METHODS: Electronic databases were searched using appropriate strategies to identify randomized controlled clinical trials in patients with refractory TN, evaluating the proportion of patients with a minimum of 50% reduction in pain or a minimum of 2 cm reduction in score in an appropriate pain scale or complete pain relief by subjective pain scales...
July 17, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28700369/pulsed-radiofrequency-in-chronic-pain
#20
Thibaut Vanneste, Astrid Van Lantschoot, Koen Van Boxem, Jan Van Zundert
PURPOSE OF REVIEW: The increasing number of publications on pulsed radiofrequency (PRF) treatment of chronic pain reflects the interest for this technique. We summarize the literature for PRF in five indications: radicular pain, trigeminal neuralgia (TN), occipital neuralgia, shoulder and knee pain. RECENT FINDINGS: The efficacy and safety of PRF adjacent to the dorsal root ganglion was documented on cervical and on lumbar level.PRF has been used for the treatment of TN...
July 11, 2017: Current Opinion in Anaesthesiology
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