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abp 980

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https://www.readbyqxmd.com/read/28341959/a-randomized-single-blind-single-dose-study-evaluating-the-pharmacokinetic-equivalence-of-proposed-biosimilar-abp-980-and-trastuzumab-in-healthy-male-subjects
#1
RANDOMIZED CONTROLLED TRIAL
Vladimir Hanes, Vincent Chow, Nan Zhang, Richard Markus
PURPOSE: This study compared the pharmacokinetic (PK) profiles of the proposed biosimilar ABP 980 and trastuzumab in healthy males. METHODS: In this single-blind study, 157 healthy males were randomized 1:1:1 to a single 6 mg/kg intravenous infusion of ABP 980, FDA-licensed trastuzumab [trastuzumab (US)], or EU-authorized trastuzumab [trastuzumab (EU)]. Primary endpoints were area under the serum concentration-time curve from time 0 to infinity (AUCinf) and maximum observed serum concentration (C max)...
May 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/21243439/epworth-sleepiness-scale-may-be-an-indicator-for-blood-pressure-profile-and-prevalence-of-coronary-artery-disease-and-cerebrovascular-disease-in-patients-with-obstructive-sleep-apnea
#2
Jing Feng, Quan-ying He, Xi-long Zhang, Bao-yuan Chen
OBJECTIVE: This study seeks to determine whether scores of a short questionnaire assessing subjective daytime sleepiness (Epworth Sleepiness Scale [ESS]) are associated with blood pressure (BP) level, BP profile, and prevalence of related coronary artery disease (CAD) and cerebrovascular disease (CVD) in obstructive sleep apnea (OSA) patients diagnosed by polysomnography (PSG). METHODS: Twenty university hospital sleep centers in China mainland were organized by the Chinese Medical Association to participate in this study...
March 2012: Sleep & Breathing, Schlaf & Atmung
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