Gozde Ozcelik, Mehmet Serdar Koca, Buket Sunbul, Fatma Yilmaz-Atay, Feride Demirhan, Busra Tiryaki, Kevser Cilenk, Saba Selvi, Nuri Ozturk
In this study, we investigate the intricate regulatory mechanisms underlying the circadian clock in Drosophila, focusing on the light-induced conformational changes in the cryptochrome (DmCry). Upon light exposure, DmCry undergoes conformational changes that prompt its binding to Timeless and Jetlag proteins, initiating a cascade crucial for the starting of a new circadian cycle. DmCry is subsequently degraded, contributing to the desensitization of the resetting mechanism. The transient and short-lived nature of DmCry protein-protein interactions (PPIs), leading to DmCry degradation within an hour of light exposure, presents a challenge for comprehensive exploration...
February 5, 2024: Photochemistry and Photobiology