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Cervical dystonia

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https://www.readbyqxmd.com/read/29151795/the-influence-of-occlusal-stabilization-appliances-on-cervical-dystonia-symptoms
#1
Camelia Navrotchi, Mîndra Eugenia Badea
Objectives: The aim of this study was to assess the therapeutic efficiency of the occlusal stabilization appliance (OSA) in patients with cervical dystonia (CD). Methods: The study included 11 patients aged between 29 and 80 years, 7 women and 4 men, diagnosed with primary CD. The patients underwent an extra- and intra-oral clinical examination, followed by para-clinical examinations, necessary for the specifications of the OSA. The following data were recorded: demographic parameters, CD duration, management of the disease, dental impression, recording of the centric relationship, recording of the position of the upper jaw with the facial bow...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29137852/dysarthria-in-pallidal-deep-brain-stimulation-in-dystonia-depends-on-the-posterior-location-of-active-electrode-contacts-a-pilot-study
#2
K A M Pauls, P J Bröckelmann, S Hammesfahr, J Becker, A Hellerbach, V Visser-Vandewalle, T A Dembek, I G Meister, L Timmermann
BACKGROUND: Pallidal Deep Brain Stimulation (GPi-DBS) is an efficient treatment for primary dystonia. We investigated stimulation-induced dysarthria, which is the most frequent side-effect of GPi-DBS. METHODS: Speech was recorded while reading a standard text, and performing rapid syllable repetitions ON and OFF DBS in ten dystonia patients (6 men; 3 cervical, 4 segmental, 3 generalized, unselected for DBS-related speech impairments). Speech and articulation rate, pauses, and syllable repetition rates were extracted via acoustic analysis...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29130551/a-localized-pallidal-physiomarker-in-cervical-dystonia
#3
Wolf-Julian Neumann, Andreas Horn, Siobhan Ewert, Julius Huebl, Christof Brücke, Colleen Slentz, Gerd-Helge Schneider, Andrea A Kühn
OBJECTIVE: Deep brain stimulation (DBS) allows for direct recordings of neuronal activity from the human basal ganglia. In Parkinson's disease, a disease-specific physiomarker was identified that is now used to investigate adaptive closed-loop stimulation in first studies. In dystonia such a physiomarker is missing. METHODS: Pallidal oscillations were recorded from 153 contact pairs in 27 patients. We investigated whether power amplitudes in theta and beta bands correlate with dystonic symptom severity across patients...
November 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29116410/botulinum-toxin-therapy-in-patients-with-oral-anticoagulation-is-it-safe
#4
Christoph Schrader, Markus Ebke, Fereshte Adib Saberi, Dirk Dressler
When used therapeutically, botulinum toxin (BT) has to be injected into its target tissues. All manufacturers warn not to do so in patients with oral anticoagulation to avoid haematoma. We wanted to study the haematoma frequency (HF) in patients with anticoagulation receiving BT therapy. 32 patients (16 females, 16 males, age 69.3 ± 10.0 years) with blepharospasm (n = 6), hemifacial spasm (n = 8), post-stroke spasticity (n = 16), and cervical dystonia (n = 2) received BT therapy (needle size 27G, post-injection tissue compression) whilst on anticoagulation (anticoagulation group, AG)...
November 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29114239/botulinumtoxin-improves-both-generic-and-disease-specific-quality-of-life-in-cervical-dystonia
#5
Daniel Weiss, Leonhard Hieber, Justine Sturm, Axel Börtlein, Ingo Mayr, Matthias Appy, Benedicta Kühnler, Joachim Buchthal, Christian Dippon, Guy Arnold, Tobias Wächter
Botulinumtoxin injection (BoNT) into affected muscles is effective to improve motor symptoms of cervical dystonia (CD) by reducing muscle contraction and involuntary dystonic movement and posturing. However, the understanding of the effect on health-related quality of life (HR-QoL) and patient referral under HR-QoL aspects is incomplete. In this open-label clinical prospective observational study, we characterized the outcomes in CD (n = 159) from botulinumtoxin on both generic HR-QoL (EuroQol; EQ-5D-5L) and disease-specific HR-QoL [craniocervical dystonia questionnaire (CDQ-24)]...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29111426/when-movement-disorders-hurt-addressing-pain-in-hyperkinetic-disorders
#6
Maja Relja, Vladimir Miletić
Pain is an important nonmotor symptom in movement disorders. Dystonia is a hyperkinetic movement disorder characterized by involuntary, sustained or intermittent muscle contractions causing abnormal movements, postures or both. Contrary to common views the nonmotor symptoms are present in dystonia patients. Pain is a prevailing feature of cervical dystonia (CD), the most common form of focal dystonia. The mechanism of pain in CD remains mostly unknown, but there are growing evidence that it could not be only the consequence of muscle hyperactivity...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29106650/selective-cervical-denervation-for-cervical-dystonia-modification-of-the-bertrand-procedure
#7
Thomas J Wilson, Robert J Spinner
BACKGROUND: Cervical dystonia, commonly referred to as spasmodic torticollis, is a neurological disorder characterized by aberrant, involuntary contraction of the muscles of the neck and shoulders. One surgical option that can be considered is selective cervical denervation. OBJECTIVE: To report our modification of the Bertrand procedure for selective cervical denervation. METHODS: Our modification of the Bertrand procedure for selective cervical denervation is reported with intraoperative photographs and schematic depictions of the operative steps...
July 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29101737/is-perception-of-visual-verticality-intact-in-patients-with-idiopathic-cervical-dystonia
#8
Joke De Pauw, Willem De Hertogh, Rudy Mercelis, Wim Saeys, Ann Hallemans, Sarah Michiels, Steven Truijen, Patrick Cras
Idiopathic cervical dystonia (CD) is a focal dystonia characterized by an abnormal tilted or twisted head position. This abnormal head position could lead to a distorted perception of the visual vertical and spatial orientation. The aim of this cross-sectional study was to investigate whether the perception of the visual vertical is impaired in patients with CD. The subjective visual vertical test (SVV) was measured in 24 patients with CD and 30 controls. The SVV test is conducted in a completely darkened room...
November 3, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29100066/neuronal-activity-patterns-in-the-ventral-thalamus-comparison-between-parkinson-s-disease-and-cervical-dystonia
#9
Dmitriy Devetiarov, Ulia Semenova, Svetlana Usova, Alexey Tomskiy, Vladimir Tyurnikov, Dinara Nizametdinova, Artem Gushcha, Elena Belova, Alexey Sedov
OBJECTIVE: The aim of this study was to distinguish neuronal activity patterns in the human ventral thalamus and reveal common and disease-specific features in patients with Parkinson's disease (PD) and cervical dystonia (CD). METHODS: Single unit activity of neurons was recorded during microelectrode-guided thalamotomies. We classified neurons of surgical target and surrounding area into patterns and compared their characteristics and responsiveness to voluntary movement between PD and CD patients...
December 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29089923/sensory-alterations-in-patients-with-isolated-idiopathic-dystonia-an-exploratory-quantitative-sensory-testing-analysis
#10
Lejla Paracka, Florian Wegner, Christian Blahak, Mahmoud Abdallat, Assel Saryyeva, Dirk Dressler, Matthias Karst, Joachim K Krauss
Abnormalities in the somatosensory system are increasingly being recognized in patients with dystonia. The aim of this study was to investigate whether sensory abnormalities are confined to the dystonic body segments or whether there is a wider involvement in patients with idiopathic dystonia. For this purpose, we recruited 20 patients, 8 had generalized, 5 had segmental dystonia with upper extremity involvement, and 7 had cervical dystonia. In total, there were 13 patients with upper extremity involvement...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29084148/neurophysiological-measures-of-efficacy-and-safety-for-botulinum-toxin-injection-in-facial-and-bulbar-muscles-special-considerations
#11
REVIEW
Mohammad Alimohammadi, Anna Rostedt Punga
Botulinum toxin (BoNT) injections into facial and bulbar muscles are widely and increasingly used as medical treatments for cervical and facial dystonia, facial hemispasm, correction of facial palsy, hyperhidrosis, as well as cosmetic treatment of glabellar lines associated with grief and anger. Although BoNT treatment is generally considered safe, the diffusion of the toxin to surrounding muscles may result in complications, including difficulties swallowing, in a dose-dependent manner. The sensitivity of clinical examination for detecting adverse events after BoNT treatment is limited...
October 30, 2017: Toxins
https://www.readbyqxmd.com/read/29071431/lower-serotonin-transporter-binding-in-patients-with-cervical-dystonia-is-associated-with-psychiatric-symptoms
#12
E Zoons, J Booij, J D Speelman, Y E M Dreissen, M Smit, M A J Tijssen
BACKGROUND: Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonergic and dopaminergic systems are closely related. As serotonin is involved in the pathophysiology of psychiatric symptoms and jerks, we expected an altered serotoninergic system in CD. We hypothesized that CD is associated with reduced serotonin transporter (SERT) binding, more specific that SERT binding is lower in CD patients with psychiatric symptoms and/or jerks/tremor compared to those without, and to controls...
October 25, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29066869/treatment-satisfaction-with-botulinum-toxin-a-comparison-between-blepharospasm-and-cervical-dystonia
#13
Bernd Leplow, Anna Eggebrecht, Johannes Pohl
BACKGROUND: Differential effects of botulinum toxin (BoNT) treatment in cervical dystonia (CD) and blepharospasm (BSP) treatment satisfaction and emotional responses to a life with a disabling condition were investigated. Special interest was drawn to the course within a BoNT treatment cycle and the effects of subjective well-being vs perceived intensity of motor symptoms and quality of life. METHODS: A questionnaire was distributed among 372 CD patients and 125 BSP patients, recruited from 13 BoNT centers throughout Germany...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29062576/does-the-somatosensory-temporal-discrimination-threshold-change-over-time-in-focal-dystonia
#14
Antonella Conte, Gina Ferrazzano, Daniele Belvisi, Nicoletta Manzo, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli
BACKGROUND: The somatosensory temporal discrimination threshold (STDT) is defined as the shortest interval at which an individual recognizes two stimuli as asynchronous. Some evidence suggests that STDT depends on cortical inhibitory interneurons in the basal ganglia and in primary somatosensory cortex. Several studies have reported that the STDT in patients with dystonia is abnormal. No longitudinal studies have yet investigated whether STDT values in different forms of focal dystonia change during the course of the disease...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29057844/functional-characterization-of-rare-rab12-variants-and-their-role-in-musician-s-and-other-dystonias
#15
REVIEW
Eva Hebert, Friederike Borngräber, Alexander Schmidt, Aleksandar Rakovic, Ingrid Brænne, Anne Weissbach, Jennie Hampf, Eva-Juliane Vollstedt, Leopold Größer, Susen Schaake, Michaela Müller, Humera Manzoor, Hans-Christian Jabusch, Daniel Alvarez-Fischer, Meike Kasten, Vladimir S Kostic, Thomas Gasser, Kirsten E Zeuner, Han-Joon Kim, Beomseok Jeon, Peter Bauer, Eckart Altenmüller, Christine Klein, Katja Lohmann
Mutations in RAB (member of the Ras superfamily) genes are increasingly recognized as cause of a variety of disorders including neurological conditions. While musician's dystonia (MD) and writer's dystonia (WD) are task-specific movement disorders, other dystonias persistently affect postures as in cervical dystonia. Little is known about the underlying etiology. Next-generation sequencing revealed a rare missense variant (c.586A>G; p.Ile196Val) in RAB12 in two of three MD/WD families. Next, we tested 916 additional dystonia patients; 512 Parkinson's disease patients; and 461 healthy controls for RAB12 variants and identified 10 additional carriers of rare missense changes among dystonia patients (1...
October 18, 2017: Genes
https://www.readbyqxmd.com/read/29030680/-modern-non-cosmetic-treatment-with-botulinum-toxins
#16
REVIEW
A Straube
Botulinum toxin has been known in medical history for a long time. The first scientific investigations and thoughts on possible indications in the treatment of muscular disorders were published by the German physician and poet Justinus Kerner in 1822. The physiological effect of botulinum toxin was identified in the middle of the twentieth century and the first clinical use was reported in 1977. It was first used in ophthalmology for the correction of strabismus and some years later the therapy of blepharospasm and cervical dystonia was established...
October 13, 2017: Der Internist
https://www.readbyqxmd.com/read/28983422/speech-language-pathology-evaluation-and-management-of-hyperkinetic-disorders-affecting-speech-and-swallowing-function
#17
REVIEW
Julie M Barkmeier-Kraemer, Heather M Clark
BACKGROUND: Hyperkinetic dysarthria is characterized by abnormal involuntary movements affecting respiratory, phonatory, and articulatory structures impacting speech and deglutition. Speech-language pathologists (SLPs) play an important role in the evaluation and management of dysarthria and dysphagia. This review describes the standard clinical evaluation and treatment approaches by SLPs for addressing impaired speech and deglutition in specific hyperkinetic dysarthria populations. METHODS: A literature review was conducted using the data sources of PubMed, Cochrane Library, and Google Scholar...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28961350/motor-cortical-plasticity-relates-to-symptom-severity-and-clinical-benefit-from-deep-brain-stimulation-in-cervical-dystonia
#18
Daniel Kroneberg, Philip Plettig, Gerd-Helge Schneider, Andrea A Kühn
OBJECTIVE: To investigate the relationship between motor cortical plasticity, intracortical inhibition, and clinical response to pallidal deep brain stimulation (DBS) in patients with cervical dystonia (CD). MATERIALS AND METHODS: Response to paired associative stimulation (PAS) and short interval intracortical inhibition (SICI) were assessed in patients with CD before and after three months of DBS and correlated with severity of dystonic symptoms as assessed by Toronto-Western-Spasmodic Torticollis Rating Scale (TWSTRS) severity score...
September 29, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28948067/cervical-sensorimotor-control-in-idiopathic-cervical-dystonia-a%C3%A2-cross-sectional-study
#19
Joke De Pauw, Rudy Mercelis, Ann Hallemans, Sarah Michiels, Steven Truijen, Patrick Cras, Willem De Hertogh
OBJECTIVES: Patients with idiopathic adult-onset cervical dystonia (CD) experience an abnormal head posture and involuntary muscle contractions. Although the exact areas affected in the central nervous system remain uncertain, impaired functions in systems stabilizing the head and neck are apparent such as the somatosensory and sensorimotor integration systems. The aim of the study is to investigate cervical sensorimotor control dysfunction in patients with CD. MATERIAL AND METHODS: Cervical sensorimotor control was assessed by a head repositioning task in 24 patients with CD and 70 asymptomatic controls...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28943258/adaptation-of-feedforward-movement-control-is-abnormal-in-patients-with-cervical-dystonia-and-tremor
#20
Laura Avanzino, Andrea Ravaschio, Giovanna Lagravinese, Gaia Bonassi, Giovanni Abbruzzese, Elisa Pelosin
OBJECTIVE: It is under debate whether the cerebellum plays a role in dystonia pathophysiology and in the expression of clinical phenotypes. We investigated a typical cerebellar function (anticipatory movement control) in patients with cervical dystonia (CD) with and without tremor. METHODS: Twenty patients with CD, with and without tremor, and 17 healthy controls were required to catch balls of different load: 15 trials with a light ball, 25 trials with a heavy ball (adaptation) and 15 trials with a light ball (post-adaptation)...
September 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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