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Cervical dystonia

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https://www.readbyqxmd.com/read/29772695/botulinum-toxin-type-a-injection-for-cervical-dystonia-in-adults-with-dyskinetic-cerebral-palsy
#1
You Gyoung Yi, Keewon Kim, Youbin Yi, Young-Ah Choi, Ja-Ho Leigh, Moon Suk Bang
We aimed to evaluate the efficacy and safety of injecting botulinum toxin A (BoNT-A) into the neck muscles to treat cervical dystonia (CD) in patients with dyskinetic cerebral palsy (CP). This was a randomized, double-blinded, placebo-controlled trial with cross-over design. We prospectively enrolled adults with dyskinetic CP who were over 20 years old and had been clinically diagnosed with CD for more than one year. The primary outcome measure was the change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at four weeks from the baseline TWSTRS...
May 16, 2018: Toxins
https://www.readbyqxmd.com/read/29770609/whole-exome-sequencing-for-variant-discovery-in-blepharospasm
#2
Jun Tian, Satya R Vemula, Jianfeng Xiao, Enza Maria Valente, Giovanni Defazio, Simona Petrucci, Angelo Fabio Gigante, Monika Rudzińska-Bar, Zbigniew K Wszolek, Kathleen D Kennelly, Ryan J Uitti, Jay A van Gerpen, Peter Hedera, Elizabeth J Trimble, Mark S LeDoux
BACKGROUND: Blepharospasm (BSP) is a type of focal dystonia characterized by involuntary orbicularis oculi spasms that are usually bilateral, synchronous, and symmetrical. Despite strong evidence for genetic contributions to BSP, progress in the field has been constrained by small cohorts, incomplete penetrance, and late age of onset. Although several genetic etiologies for dystonia have been identified through whole-exome sequencing (WES), none of these are characteristically associated with BSP as a singular or predominant manifestation...
May 16, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29737565/pain-processing-in-functional-and-idiopathic-dystonia-an-exploratory-study
#3
Francesca Morgante, Angela Matinella, Elisa Andrenelli, Lucia Ricciardi, Cosimo Allegra, Carmen Terranova, Paolo Girlanda, Michele Tinazzi
BACKGROUND: Pain is often experienced by patients with functional dystonia and idiopathic cervical dystonia and is likely to be determined by different neural mechanisms. OBJECTIVE: In this exploratory study, we tested the sensory-discriminative and cognitive-emotional component of pain in patients with functional and idiopathic dystonia. METHODS: Ten patients with idiopathic cervical dystonia, 12 patients with functional dystonia, and 16 age- and sex-matched healthy controls underwent psychophysical testing of tactile and pain thresholds and pain tolerance...
May 8, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29731634/long-term-quality-of-life-in-cervical-dystonia-after-treatment-with-abobotulinum-toxin-a-a-2-year-prospective-study
#4
Subsai Kongsaengdao, Narong Maneeton, Benchalak Maneeton
Background: The short-term quality of life (QoL) in cervical dystonia (CD) after treating with abobotulinum toxin A (Abo-BTX A) and neubotulinum toxin A (Neu-BTX A) have been studied in Thai CD patients. However; the long-term study has not been published. Objective: The aim of the present study was to determine long-term improvement of the health-related quality of life (HRQoL) after eight injections of Abo-BTX A over 2 years in CD patients. Patients and methods: A 2-year prospective study on the QoL of CD patients, as measured by HRQoL, before and after receiving eight injections of Abo-BTX A at 3-month intervals over a 2-year treatment period was performed...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29724604/pain-in-focal-dystonias-a-focused-review-to-address-an-important-component-of-the-disease
#5
REVIEW
Micol Avenali, R De Icco, M Tinazzi, G Defazio, L Tronconi, G Sandrini, C Tassorelli
Focal dystonia is characterized by involuntary muscle contractions that cause abnormal postures and/or twisting movements in a segment of the body. Motor symptoms have a major impact on disability in this condition, but the presence of pain represents an additional source of impairment and poor quality of life. Notwithstanding that pain occurs in up to 70% of patients with cervical dystonia and in a relevant proportion of subjects with focal dystonia of the limbs, it has received very little attention from researchers and controlled trials are scant...
April 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29724603/high-prevalence-of-olfactory-dysfunction-in-cervical-dystonia
#6
Milena Marek, Susanne Linnepe, Christine Klein, Thomas Hummel, Sebastian Paus
INTRODUCTION: Olfactory dysfunction has been established as a frequent non-motor symptom in neurodegenerative and movement disorders such as Parkinson's disease, Alzheimer's disease, and hereditary ataxias. To expand knowledge of non-motor symptoms in dystonia, and to test for a potential endophenotype, we examined olfactory function in cervical dystonia (CD). METHODS: In patients with CD, and neurologically healthy controls, olfactory function was examined by "Sniffin' Sticks", a test of nasal chemosensory function based on pen-like odor dispensing devices...
April 25, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29716720/clinical-experience-with-patients-with-spasmodic-dysphonia-and-primary-meige-syndrome
#7
María Fernanda Pedrero-Escalas, Isabel García-López, Susana Santiago-Pérez, Francisco Vivancos, Javier Gavilán
INTRODUCTION: Meige syndrome (MS) is part of the group of segmental cranial dystonias, which affect more than two cranial muscle groups. Specifically, blepharospasm is associated with another cranial dystonia (oromandibular, cervical or laryngeal). The aim of this paper was to report our experience in patients with spasmodic dysphonia (SD) associated with primary MS. MATERIAL AND METHODS: A retrospective study involving 8 patients between May 2010 and June 2015...
April 28, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29704573/cortical-modulation-of-brainstem-circuits-is-abnormal-in-cervical-dystonia
#8
Oya Öztürk, Ayşegül Gündüz, Meral E Kızıltan
OBJECTIVE: In healthy subjects, magnitude of hand-evoked blink reflex (BR) is increased if the stimulated hand is positioned in the peripersonal space. Here, we aimed to investigate the modulation of hand-evoked BR in peripersonal space to understand alterations of cortical modulations of subcortical structures in cervical dystonia. PATIENTS AND METHOD: We recruited 23 patients with idiopathic cervical dystonia and 21 healthy subjects, all of whom had hand-evoked BR...
April 25, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29670567/gaba-a-receptor-availability-changes-underlie-symptoms-in-isolated-cervical-dystonia
#9
Brian D Berman, Rebecca Tran Pollard, Erika Shelton, Ramesh Karki, Peter M Smith-Jones, Yubin Miao
GABAA receptor availability changes within sensorimotor regions have been reported in some isolated forms of dystonia. Whether similar abnormalities underlie symptoms in cervical dystonia is not known. In the present study, a total of 15 cervical dystonia patients and 15 age- and sex-matched controls underwent 11 C-flumazenil PET/CT scanning. The density of available GABAA receptors was estimated using a Simplified Reference Tissue Model 2. Group differences were evaluated using a two-sample T -test, and correlations with dystonia severity, as measured by the Toronto Western Spasmodic Torticollis Rating Scale, and disease duration were evaluated using a regression analysis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29607887/pilot-study-of-a-device-to-induce-the-hanger-reflex-in-patients-with-cervical-dystonia
#10
Takashi Asahi, Michi Sato, Takuto Nakamura, Yuki Kon, Hiroyuki Kajimoto, Genko Oyama, Akito Hayashi, Kazunori Tanaka, Shunya Nakane, Takao Takeshima, Masami Fujii, Satoshi Kuroda
The hanger reflex (HR) is an involuntary head rotation that occurs in response to a clothes hanger encircling the head and compressing the unilateral fronto-temporal area. Here, we developed an elliptical device to induce the HR and examined its utility for the treatment of cervical dystonia (CD). The study included 19 patients with rotational-type CD. The device was applied to each subject's head for at least 30 min/day for 3 months. Severity scores on part 1 of the Toronto Western Spasmodic Torticollis Rating Scale were evaluated at baseline and after the 3-month trial...
March 31, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29569175/cervical-dystonia-and-substance-abuse
#11
Abhimanyu Mahajan, Joseph Jankovic, Laura Marsh, Achint Patel, H A Jinnah, Cynthia Comella, Richard Barbano, Joel Perlmutter, Neepa Patel
OBJECTIVE: To investigate the prevalence of substance abuse (SA) in patients with cervical dystonia (CD) and to correlate it with prevalence of psychiatric disorders. METHODS: Data on anxiety, depression, dystonia severity, and substance abuse were collected from ten sites participating in the Dystonia Coalition. Patients were divided into two groups according to the presence of SA, utilizing Structured Clinical Interview for DSM-4 criteria. Wilcoxon Rank-Sum test was used to analyze the difference in median scores on the questionnaires between the groups...
April 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29565281/sensory-trick-in-a-patient-with-cervical-dystonia-insights-from-magnetoencephalography
#12
Abhimanyu Mahajan, Andrew Zillgitt, Susan M Bowyer, Christos Sidiropoulos
BACKGROUND: The proposed mechanisms for the sensory trick include peripheral sensory feedback to aid in correcting abnormal posture or movement. CASE REPORT: A 53-year-old woman with cervical dystonia underwent magnetoencephalography pre- and post-botulinum toxin injection and sensory trick, which was described as yawning. Study revealed connectivity between the left frontal and inferior frontal gyrus before yawning, which changed to the visual cortex and right middle frontal gyrus with yawning...
March 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29557988/personalized-botulinum-toxin-type-a-therapy-for-cervical-dystonia-based-on-kinematic-guidance
#13
Olivia Samotus, Jack Lee, Mandar Jog
BACKGROUND: Botulinum toxin type A (BoNT-A) injections is the accepted first-line therapy for cervical dystonia (CD), however, numerous patients discontinue treatment early due to perceived sub-optimal relief. To improve BoNT-A therapy for CD, proper assessment of neck motion and selection of relevant muscles and dosing must be met. Kinematic technology may improve treatment outcomes by guiding physicians to better tailor muscle selection and BoNT-A dosing for CD therapy. METHODS: 28 CD participants were placed into either group: expert injector determined injection patterns by visual assessment ("vb") versus injection patterns based on kinematics interpreted by an expert injector ("kb")...
March 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29541052/relationships-between-serotonin-transporter-binding-in-the-raphe-nuclei-basal-ganglia-and-hippocampus-with-clinical-symptoms-in-cervical-dystonia-a-11-c-dasb-positron-emission-tomography-study
#14
Marenka Smit, David Vállez García, Bauke M de Jong, Evelien Zoons, Jan Booij, Rudi A Dierckx, Antoon T Willemsen, Erik F de Vries, Anna L Bartels, Marina A Tijssen
Purpose: Alterations of the central serotonergic system have been implicated in the pathophysiology of dystonia. In this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (SERT) binding contributes to the pathophysiology of cervical dystonia (CD), concerning both motor and non-motor symptoms (NMS). Methods: We assessed the non-displaceable binding potential (BPND ) using the selective SERT tracer [11 C]DASB and positron emission tomography (PET) in 14 CD patients and 12 age- and gender-matched controls...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29530726/minimal-clinically-important-change-in-the-toronto-western-spasmodic-torticollis-rating-scale
#15
Alberto J Espay, Richard Trosch, Gustavo Suarez, Jonathan Johnson, Dominic Marchese, Cynthia Comella
OBJECTIVES: To characterize the minimal clinically important change (MCIC) after treatment in cervical dystonia patients using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). METHODS: Changes in the TWSTRS from an observational study of abobotulinumtoxinA in the routine management of cervical dystonia (NCT01314365) were analyzed using the Patient Global Impression of Change (PGIC) as anchor. RESULTS: For the overall population (N = 304, baseline TWSTRS-Total score 43...
March 7, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29508906/pedunculopontine-nucleus-cholinergic-deficiency-in-cervical-dystonia
#16
Karin Mente, Nancy A Edwards, Demelio Urbano, Abhik Ray-Chaudhury, Diego Iacono, Ana Tereza Di Lorenzo Alho, Eduardo Joaquim Lopes Alho, Edson Amaro, Silvina G Horovitz, Mark Hallett
BACKGROUND: The etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in dystonia animal models and human imaging studies. Some animal models have cholinergic neuronal loss in the striatum and increased acetylcholinesterase activity in the pedunculopontine nucleus. OBJECTIVES: The objective of this study was to determine the presence of cholinergic abnormalities in the putamen and pedunculopontine nucleus in cervical dystonia human brain donors...
March 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29503330/botulinum-toxin-in-movement-disorders
#17
REVIEW
Priyanka Tater, Sanjay Pandey
Botulinum toxin has gained immense popularity since its introduction for therapeutic use. It is used in a variety of movement disorders like hemi-facial spasm, focal dystonias like blepharospasm, cervical dystonia, oromandibular dystonia, limb dystonias. It is also being used in patients with tremors, tics and for a variety of indications in Parkinson's disease as well. There are eight subtypes of toxins available, but type A and B are the ones used in movement disorder clinics. The toxin mainly acts by inhibiting the release of acetylcholine at the neuromuscular junction and causing weakness...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29488101/a-simplified-ultrasonography-guided-approach-for-neurotoxin-injection-into-the-obliquus-capitis-inferior-muscle-in-spasmodic-torticollis
#18
Uwe Walter, Ales Dudesek, Urban M Fietzek
The obliquus capitis inferior (OCI) muscle may be crucially involved in generating the tremulous component of spasmodic torticollis. This study was undertaken to evaluate the efficacy of a simplified ultrasonography-guided approach of botulinum neurotoxin injection into the OCI in the management of spasmodic torticollis. Here, a novel off-plane technique of ultrasonography-guided botulinum neurotoxin injection into the OCI is demonstrated on video. We investigated its effect in five patients with tremulous torticollis with only partial response to conventional injection technique not injecting OCI...
February 27, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29480513/-myths-and-evidence-on-the-use-of-botulinum-toxin-neuropharmacology-and-dystonia
#19
P J Garcia-Ruiz, P Sanz-Cartagena, J C Martinez-Castrillo, B Ares-Pensado, I Aviles-Olmos, M Blazquez-Estrada, S Fanjul-Arbos, J Garcia-Caldentey, J Gazulla, J Gutierrez-Garcia, B Huete-Anton, C Lucas-Rodenas, M R Luquin, I Martinez-Torres, P Medialdea-Natera, A Mendoza-Rodriguez, P Mir-Rivera, I J Posada, J Ruiz-Martinez, P Sanchez-Alonso, J M Trejo-Gabriel Y Galan, L Vela, J L Pena-Segura
INTRODUCTION: Botulinum toxin type A (BTA) is a bacterial endotoxin, whose therapeutic use has had a dramatic impact on different neurological disorders, such as dystonia and spasticity. AIM: To analyze and summarize different questions about the use of BTA in our clinical practice. DEVELOPMENT: A group of experts in neurology developed a list of topics related with the use of BTA. Two groups were considered: neuropharmacology and dystonia...
March 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29478149/botulinum-toxin-treatment-of-movement-disorders
#20
REVIEW
Yasaman Safarpour, Bahman Jabbari
Botulinum neurotoxins (BoNTs) are now among the most widely used therapeutic agents in clinical medicine with indications applied to the fields of movement disorders, pain disorders, and autonomic dysfunction. In this literature review, the efficacy and utility of BoNTs in the field of movement disorders are assessed using the criteria of the Guideline Development Subcommittee of the American Academy of Neurology. The literature supports a level A efficacy (established) for BoNT therapy in cervical dystonia and a level B efficacy (probably effective) for blepharospasm, hemifacial spasm, laryngeal dystonia (spasmodic dysphonia), task-specific dystonias, essential tremor, and Parkinson rest tremor...
February 24, 2018: Current Treatment Options in Neurology
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