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https://www.readbyqxmd.com/read/29345748/kudingcha-and-fuzhuan-brick-tea-prevent-obesity-and-modulate-gut-microbiota-in-high-fat-diet-fed-mice
#1
Guijie Chen, Minhao Xie, Zhuqing Dai, Peng Wan, Hong Ye, Xiaoxiong Zeng, Yi Sun
SCOPE: Kudingcha (KDC) from Ilex kudingcha and Fuzhuan brick tea (FBT) are popular beverages in China, and their preventive and therapeutic roles in metabolic disorders have been reported. However, the relationship between the gut microbiota modulatory effects of KDC and FBT and prevention of obesity is still not clearly understood. METHODS AND RESULTS: KDC and FBT were tested individually for their capacities to prevent obesity and modulate the gut microbiota in high-fat diet (HFD) fed C57BL/6J mice...
January 18, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29326761/prevalence-rate-of-adolescent-idiopathic-scoliosis-results-of-school-based-screening-in-surabaya-indonesia
#2
I S Komang-Agung, S B Dwi-Purnomo, A Susilowati
Introduction: Scoliosis is a lateral spinal deformity of 10 degrees or more, resulting in a C-shaped or S-shaped curve of the spine. Information about adolescent idiopathic scoliosis (AIS) prevalence rate is important not only for paediatric health care planning strategy but also for parent's awareness. This study aims to find the suitable inclination cut-off angle and the prevalence rate of AIS in Surabaya, Indonesia. Materials and Methods: This is a descriptive cross-sectional study conducted in 2010. We performed stratified random sampling of 784 Elementary and Junior High School students in Surabaya between 9-16 years of age...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29315853/stirring-up-acceptor-phase-and-controlling-morphology-via-choosing-appropriate-rigid-aryl-rings-as-lever-arms-in-symmetry-breaking-benzodithiophene-for-high-performance-fullerene-and-fullerene-free-polymer-solar-cells
#3
Deyu Liu, Junyi Wang, Chunyang Gu, Yonghai Li, Xichang Bao, Renqiang Yang
Two series of new polymers with medium and wide bandgaps to match fullerene (PC71 BM) and fullerene-free 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']dithiophene (ITIC) acceptors are designed and synthesized, respectively. For constructing the key donor building blocks, the effective symmetry-breaking strategy is employed. Two common aromatic rings (thiophene and benzene) are chosen as one side substituted groups in the asymmetric benzodithiophene (BDT) monomers...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29314160/are-parental-self-efficacy-and-family-flexibility-mediators-of-treatment-for-anorexia-nervosa
#4
Shiri Sadeh-Sharvit, Katherine D Arnow, Lilya Osipov, James D Lock, Booil Jo, Sarah Pajarito, Harry Brandt, Elizabeth Dodge, Katherine A Halmi, Craig Johnson, Walter Kaye, Denise Wilfley, W Stewart Agras
OBJECTIVE: Family-based treatment (FBT) for adolescent anorexia nervosa (AN) promotes faster weight restoration when compared to other treatments. However, the mechanisms through which this occurs are not clarified. This study explored the trajectories of parental self-efficacy and perceived family flexibility during FBT and systemic family therapy (SyFT). We also explored whether parental self-efficacy mediates the effects of treatment on weight gain early in treatment. METHOD: 158 adolescents (12-18 years old; 89% girls) and their parents were randomized to FBT or SyFT...
January 4, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29309954/impaired-theory-of-mind-in-chinese-children-and-adolescents-with-idiopathic-generalized-epilepsy-association-with-behavioral-manifestations-of-executive-dysfunction
#5
Ting Zhang, Lingyan Chen, Yu Wang, Mengmeng Zhang, Lanlan Wang, Xiangjun Xu, Gairong Xiao, Jing Chen, Yeru Shen, Nong Zhou
BACKGROUND: Epilepsy is a common neurological disorder with a core feature of cognitive impairments. Previous studies showed that patients with focal epilepsy have deficits in both theory of mind (ToM) and executive function (EF). However, there are few studies of ToM in patients with idiopathic generalized epilepsy (IGE), especially in populations with pediatric epilepsy. The aim of this study was to examine the characteristics of ToM and EF, including some of their subcomponents, and explore the relationship between them in Chinese children with IGE...
January 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29282801/augmentative-approaches-in-family-based-treatment-for-adolescents-with-restrictive-eating-disorders-a-systematic-review
#6
REVIEW
Imogen Lim Richards, Anni Subar, Stephen Touyz, Paul Rhodes
OBJECTIVE: To systematically review the literature reporting outcomes of augmentative family-based treatment (FBT) interventions for adolescents with restrictive eating disorders (EDs). METHOD: Articles were identified through a systematic search of five electronic databases (PsycINFO, MEDLINE, EMBASE, CINAHL, Cochrane Database). RESULTS: Thirty articles were included, reporting on FBT augmentations featuring adjunctive treatment components, modified treatment structure and/or content with adherence to FBT principles, and adaptations allowing FBT delivery in different settings...
December 28, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29218761/naturalistic-outcome-of-family-based-inpatient-treatment-for-adolescents-with-anorexia-nervosa
#7
Inger Halvorsen, Deborah Lynn Reas, Jan-Vegard Nilsen, Øyvind Rø
BACKGROUND: Outpatient family-based treatment (FBT) is the best-documented treatment for adolescent anorexia nervosa (AN), but research is scarce on FBT adapted to inpatient settings. AIM: The naturalistic outcome of inpatient FBT for adolescent AN was investigated. METHODS: Thirty-seven (65%) of 57 patients who received inpatient FBT at a tertiary adolescent eating disorders (ED) unit participated in a follow-up interview (mean 4.5 ± 1...
December 8, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29206936/birthweight-of-singletons-born-after-cleavage-stage-or-blastocyst-transfer-in-fresh-and-warming-cycles
#8
Anick De Vos, Samuel Santos-Ribeiro, Lisbet Van Landuyt, Hilde Van de Velde, Herman Tournaye, Greta Verheyen
STUDY QUESTION: Does extended culture to the blastocyst stage affect singleton birthweight after either fresh or vitrified-warmed embryo transfer? SUMMARY ANSWER: Singleton birthweight z-scores did not vary significantly after a fresh blastocyst transfer, whereas the additional effect of vitrification remains inconclusive. WHAT IS KNOWN ALREADY: Observational studies have associated extended culture with an increased risk of preterm birth and low birthweight...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29163941/exploring-the-effects-of-a-family-admissions-program-for-adolescents-with-anorexia-nervosa
#9
Keren Fink, Paul Rhodes, Jane Miskovic-Wheatley, Andrew Wallis, Stephen Touyz, Julian Baudinet, Sloane Madden
Background: This study investigated patient experience in a Family Admissions Program (FAP) - a pilot treatment program for adolescents with Anorexia Nervosa at the Children's Hospital, Westmead. Based on Maudsley Family Based Treatment (FBT), the FAP involves an adolescent and his/her family undergoing a two-week family-based hospital admission at the outset of treatment. The program aims to increase intensity and support to a level needed by some families struggling to engage with or access FBT...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29152825/feasibility-study-combining-art-therapy-or-cognitive-remediation-therapy-with-family-based-treatment-for-adolescent-anorexia-nervosa
#10
James Lock, Kathleen Kara Fitzpatrick, William S Agras, Noam Weinbach, Booil Jo
Adolescents with anorexia nervosa who have obsessive-compulsive (OC) features respond poorly to family-based treatment (FBT). This study evaluated the feasibility of combining FBT with either cognitive remediation therapy (CRT) or art therapy (AT) to improve treatment response in this at-risk group. Thirty adolescents with anorexia nervosa and OC features were randomized to 15 sessions of FBT + CRT or AT. Recruitment rate was 1 per month, and treatment attrition was 16.6% with no differences between groups...
November 20, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29105211/parental-expressed-emotion-during-two-forms-of-family-based-treatment-for-adolescent-anorexia-nervosa
#11
Erica Allan, Daniel Le Grange, Susan M Sawyer, Louise A McLean, Elizabeth K Hughes
High parental expressed emotion (EE), reflected by criticism or emotional over-involvement, has been related to poorer outcome in family-based treatment (FBT) for adolescent anorexia nervosa. This study assessed EE in 89 mothers and 64 fathers at baseline and end of treatment in a randomised trial comparing conjoint FBT to parent-focused FBT (PFT). Compared with conjoint FBT, PFT was associated with a decrease in maternal criticism, regardless of adolescent remission. Furthermore, an increase in maternal criticism was more likely to be observed in conjoint FBT (80%) than PFT (20%, p = 0...
November 3, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29084318/dose-content-and-mediators-of-family-based-treatment-for-childhood-obesity-a-multisite-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Denise E Wilfley, Brian E Saelens, Richard I Stein, John R Best, Rachel P Kolko, Kenneth B Schechtman, Michael Wallendorf, R Robinson Welch, Michael G Perri, Leonard H Epstein
Importance: Elucidation of optimal dosing and treatment content is critical for health care providers, payers, and policy makers, as well as mechanisms of change to inform intervention delivery and training initiatives for childhood obesity. Objectives: To evaluate effects, following a 4-month family-based behavioral weight loss treatment (FBT), of 2 doses (HIGH or LOW) of a weight-control intervention (enhanced social facilitation maintenance [SFM+]) vs a weight-control education condition (CONTROL; matched for dose with LOW), on child anthropometrics, and to explore putative mediators of weight loss outcomes...
December 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29079988/improving-solubility-and-oral-bioavailability-of-febuxostat-by-polymer-coated-nanomatrix
#13
Yi-Fan Yin, Yang Guo, Wen-Ding Song, Xiao-Chuan Duan, Xiu-Chai Zheng, Ting Zhong, Shuang Zhang, Xin Yao, Mei-Qi Xu, Qiang Zhang, Xuan Zhang
Here, the mesoporous silica (Sylysia 350) was selected as mesoporous material, hydroxypropyl methylcellulose (HPMC) was selected as crystallization inhibitor, and febuxostat (FBT) was selected as model drug, respectively. The FBT-Sylysia-HPMC nanomatrix (FBT@SHN) was prepared. The characteristics of FBT@SHN were investigated in vitro and in vivo. Our results indicated that the FBT in FBT@SHN was in amorphous form. The solubility and dissolution of FBT in FBT@SHN were significantly increased. The oral bioavailability of FBT in FBT@SHN was greatly improved 5...
October 27, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29077509/the-participation-of-mothers-fathers-and-siblings-in-family-based-treatment-for-adolescent-anorexia-nervosa
#14
Elizabeth K Hughes, Claire Burton, Daniel Le Grange, Susan M Sawyer
In family-based treatment (FBT) for adolescent anorexia nervosa, all family members are encouraged to attend sessions with the understanding that absences negatively impact treatment. There are, however, many obstacles to family members' attendance, and there is no research to indicate whether family member attendance improves treatment outcomes. We examined attendance patterns of 198 families who participated in FBT at a specialist pediatric eating disorders program and assessed the extent to which participation by mothers (n = 194), fathers (n = 175), and siblings (n = 165; 50% female) predicted outcome...
October 27, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29044637/the-modeled-cost-effectiveness-of-family-based-and-adolescent-focused-treatment-for-anorexia-nervosa
#15
Long Khanh-Dao Le, Jan J Barendregt, Phillipa Hay, Susan M Sawyer, Elizabeth K Hughes, Cathrine Mihalopoulos
BACKGROUND: Anorexia nervosa (AN) is a prevalent, serious mental disorder. We aimed to evaluate the cost-effectiveness of family-based treatment (FBT) compared to adolescent-focused individual therapy (AFT) or no intervention within the Australian healthcare system. METHOD: A Markov model was developed to estimate the cost and disability-adjusted life-year (DALY) averted of FBT relative to comparators over 6 years from the health system perspective. The target population was 11-18 year olds with AN of relatively short duration...
December 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29027301/challenges-of-post-authorization-safety-studies-lessons-learned-and-results-of-a-french-study-of-fentanyl-buccal-tablet
#16
REVIEW
Natalie Gavrielov-Yusim, Ilda Bidollari, Sigal Kaplan, Netta Bartov
PURPOSE: Recruiting and retaining participants in real-world studies that collect primary data are challenging. This article illustrates these challenges using a post-authorization safety study (PASS) to assess adverse events (AEs) experienced with fentanyl buccal tablet (FBT) over 3 months of treatment. METHODS: This was an observational, prospective, multicenter study in France conducted over 1 year. The study employed primary data collection in FBT-treated patients and their treating physicians via a site qualification questionnaire and patient log completed by physicians and a questionnaire and pain diary completed by patients...
October 13, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28984076/patterns-of-eating-disorder-pathology-are-associated-with-weight-change-in-family-based-behavioral-obesity-treatment
#17
Katherine N Balantekin, Jacqueline F Hayes, Daniel H Sheinbein, Rachel P Kolko, Richard I Stein, Brian E Saelens, Kelly Theim Hurst, R Robinson Welch, Michael G Perri, Kenneth B Schechtman, Leonard H Epstein, Denise E Wilfley
OBJECTIVE: Children with overweight or obesity have elevated eating disorder (ED) pathology, which may increase their risk for clinical EDs. The current study identified patterns of ED pathology in children with overweight or obesity entering family-based behavioral weight loss treatment (FBT) and examined whether children with distinct patterns differed in their ED pathology and BMI z score (zBMI) change across FBT. METHODS: Before participating in a 16-session FBT, children (N = 241) completed surveys or interviews assessing ED pathology (emotional eating, shape/weight/eating concerns, restraint, and loss of control [LOC])...
October 6, 2017: Obesity
https://www.readbyqxmd.com/read/28960173/family-behavior-therapy-for-alcohol-and-drug-problems-in-later-life
#18
Christopher P Plant, Jason M Holland
Alcohol and drug use problems among older individuals are a growing public health concern. However, few treatments have been developed for this population, despite an emerging body of literature suggesting that older substance users are more likely to benefit from interventions tailored to meet their specific needs. In particular, older adults with a history of substance abuse have expressed a preference for treatments that focus on financial problems, physical health, and mobility issues, and make attempts to prescriptively involve supportive others in treatment...
June 30, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28913833/symptom-trajectories-throughout-two-family-therapy-treatments-for-adolescent-anorexia-nervosa
#19
Stuart B Murray, Eva Pila, Daniel Le Grange, Susan M Sawyer, Elizabeth K Hughes
OBJECTIVE: This study aimed to examine the trajectory of symptom remission and affective functioning throughout the course of two family-based treatments for adolescent anorexia nervosa (AN): conjoint family-based treatment (FBT) and parent-focused treatment (PFT). METHOD: Participants were 107 adolescents (Mage  = 15.5 years, SD = 1.5) with a primary diagnosis of AN who participated in a randomized clinical trial comparing FBT (N = 55) and PFT (N = 51)...
September 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28886481/identifying-sleep-spindles-with-multichannel-eeg-and-classification-optimization
#20
Ning Mei, Michael D Grossberg, Kenneth Ng, Karen T Navarro, Timothy M Ellmore
Researchers classify critical neural events during sleep called spindles that are related to memory consolidation using the method of scalp electroencephalography (EEG). Manual classification is time consuming and is susceptible to low inter-rater agreement. This could be improved using an automated approach. This study presents an optimized filter based and thresholding (FBT) model to set up a baseline for comparison to evaluate machine learning models using naïve features, such as raw signals, peak frequency, and dominant power...
October 1, 2017: Computers in Biology and Medicine
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