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https://www.readbyqxmd.com/read/28096932/contemporary-agents-in-the-management-of-metastatic-castration-resistant-prostate-cancer
#1
REVIEW
Anil Kapoor, Christopher Wu, Bobby Shayegan, Adrian P Rybak
Docetaxel-based chemotherapy has been the standard of care for metastatic castration-resistant prostate cancer (mCRPC) since 2004. Over the past few years, there has been a significant paradigm shift in the treatment landscape of this disease. A deeper understanding of prostate cancer biology, along with the development of novel agents has created hope towards treating chemotherapy-naïve and resistant disease. Following the implementation of docetaxel as the first-line therapy for mCRPC, five novel therapies have demonstrated survival benefit in mCRPC...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28078234/radium-223-and-concomitant-therapies-prospects-and-prudence
#2
EDITORIAL
Oladapo Yeku, Susan F Slovin
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28074331/a-retrospective-analysis-of-the-first-41-mcrpc-patients-with-bone-pain-treated-with-radium-223-at-the-national-institute-of-oncology-in-hungary
#3
Zs Küronya, I Sinkovics, P Ágoston, K Bíró, I Bodrogi, I Böde, M Dank, F Gyergyay, T Vajdics, Zs Kolonics, K Nagyiványi, Á Rúzsa, L Géczi
Radium-223 dichloride is an alpha-emitting radiopharmaceutical which significantly prolongs overall survival in patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases. This was a retrospective analysis of the efficacy and safety of Radium-223 in the first 41 patients treated at a single center in Hungary. Radium-223 was given at a dose of 50 kBq/kg intravenously every 4 weeks for up to 6 cycles. Between 23rd July 2014 and 23rd February 2016, 41 patients were treated. Patient demographics, laboratory values, treatment outcomes and adverse events were collected from medical records...
January 10, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28071191/a-radium-compensator-for-ionization-measurements
#4
Rolf M Sievert
No abstract text is available yet for this article.
November 2016: Acta Radiologica
https://www.readbyqxmd.com/read/28063195/first-line-non-cytotoxic-therapy-in-chemotherapy-naive-patients-with-metastatic-castration-resistant-prostate-cancer-a-systematic-review-of-ten-randomised-clinical-trials
#5
REVIEW
Michiel H F Poorthuis, Robin W M Vernooij, R Jeroen A van Moorselaar, Theo M de Reijke
OBJECTIVE: To systematically evaluate all available treatment options in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: We systematically searched PubMed, EMBASE, and the Cochrane libraries up to March 1, 2016 for peer-reviewed publications on randomised clinical trials (RCTs). RCTs were included if progression-free survival (PFS), overall survival (OS), quality of life (QoL), or adverse events (AEs) were quantitatively evaluated...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058455/-bone-specific-therapy-with-radium-223-dichloride-castration-resistant-prostate-cancer-with-symptomatic-bone-metastases
#6
R Tauber, J Gschwend, K Scheidhauer, M Eiber, M Krönke
Radium-223 dichloride (Xofigo®, Alpharadin) is approved for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases and no known visceral metastases. As a calcium mimetic, it is integrated into osteoplastic bone lesions and emits alpha particles with high energy which leads to local destruction of tumor cells. In the 2013 published ALSYMPCA trial, a significant advantage for overall survival and quality of life in comparison to placebo was found. Recent data suggest an increased potential in combination with next generation hormonal treatment...
January 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28048765/su-f-t-57-delivered-activity-accuracy-of-radium-223-dichloride-injections-when-being-administrated-for-castration-resistant-prostate-cancer-symptomatic-bone-metastases-the-impact-of-residual-activity-in-the-spent-syringe-and-dispensing-accuracy-of-ra-223
#7
G Jennings
PURPOSE: To quantify the delivered activity accuracy of Radium 223 dichloride injections, when being administrated for castration - resistant prostate cancer, symptomatic bone metastases. The impact of residual activity in the spent syringe and dispensing accuracy of Ra 223. METHODS: The administration is by slow intravenous injection over 1 minute followed by double flushing of the 10 mL syringe and IV with saline. Eighty (80) procedures was used to investigate variations in the activity from the amount prescribed (µCi) = 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046816/su-f-p-24-radiological-disperse-device
#8
R Alam
PURPOSE: We are now living in a society of constant fear of terrorism. This topic is pertaining to give a general knowledge of what is a radiological dispersion device or RDD and in case of its detonation, what are the options open to public for a safe action in terms of reducing the exposure and knowing the proper steps. These RDD are also called dirty bombs. METHODS: Compared to nuclear weapons, dirty bombs are easy to make. In order for a terrorist organization to construct and detonate a dirty bomb, it must acquire radioactive material by stealing it or buying it through legal or illegal channels...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043005/nanozeolite-bioconjugates-labeled-with-223-ra-for-targeted-alpha-therapy
#9
Agata Piotrowska, Sylwia Męczyńska-Wielgosz, Agnieszka Majkowska-Pilip, Przemysław Koźmiński, Grzegorz Wójciuk, Edyta Cędrowska, Frank Bruchertseifer, Alfred Morgenstern, Marcin Kruszewski, Aleksander Bilewicz
INTRODUCTION: Alpha particle emitting isotopes are of considerable interest for radionuclide therapy because of their high cytotoxicity and short path length. Among the many α emitters, (223)Ra exhibits very attractive nuclear properties for application in radionuclide therapy. The decay of this radioisotope and its daughters is accompanied by the emission of four α-particles, releasing 27.9MeV of cumulative energy. Unfortunately the lack of an appropriate bifunctional ligand for radium has so far been a main obstacle for the application of (223)Ra in receptor targeted therapy...
November 17, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28034512/characterization-of-the-natural-radioactivity-of-the-first-deep-geothermal-doublet-in-flanders-belgium
#10
M Vasile, M Bruggeman, S Van Meensel, S Bos, B Laenen
Deep geothermal energy is a local energy resource that is based on the heat generated by the Earth. As the heat is continuously regenerated, geothermal exploitation can be considered as a renewable and, depending on the techniques used, a sustainable energy production system. In September 2015, the Flemish Institute for Technological Research (VITO) started drilling an exploration well targeting a hot water reservoir at a depth of about 3km on the Balmatt site near Mol. Geothermal hot water contains naturally occurring gases, chemicals and radionuclides at variable concentrations...
December 20, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28034291/radiopharmaceuticals-for-diagnosis-and-therapy-of-neuroendocrine-differentiated-prostate-cancer
#11
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
Neuroendocrine differentiation of prostate cancer (PCa) is a relatively frequent event, generally understudied, that carries important prognostic information. It is most frequently observed during the advanced stages of disease, when PCa has lost its sensitivity to androgen deprivation therapy or to chemotherapy, moderate to diffuse bone metastatic spread dominates the imaging scenario and it is responsible for painful clinical symptomatology. However, evidences indicate that neuroendocrine differentiation is a progressive phenomenon that starts at the very early part of the pathogenesis of cancer transformation contributing to it...
December 29, 2016: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28033572/persistent-organic-pollutants-heavy-metals-and-radioactivity-in-the-urban-soil-of-pri%C3%A5-tina-city-kosovo-and-metohija
#12
Ljiljana Gulan, Biljana Milenkovic, Tijana Zeremski, Gordana Milic, Biljana Vuckovic
Polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), heavy metals content and radioactivity levels were measured in 27 soil samples collected from Priština, the capital of Kosovo and Metohija. The sixteen PAHs, twelve OCPs and six PCBs congeners were determined by gas chromatography system with mass spectrometry detection. Although the use of PCBs and OCPs was prohibited decades ago residues of those compounds still existed in measurable concentrations in soils of Priština...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28024949/acute-myeloid-leukemia-after-radium-223-therapy-case-report
#13
Andreas Varkaris, Krishna Gunturu, Tarun Kewalramani, Christopher Tretter
No abstract text is available yet for this article.
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28024218/estimation-of-coastal-residence-time-of-submarine-groundwater-discharge-using-radium-progenies
#14
G Eleftheriou, C Tsabaris, D L Patiris, E G Androulakaki, R Vlastou
A methodology based on γ-spectrometry measurements of untreated coastal water samples is proposed for the direct estimation of coastal residence time of submarine discharged groundwater. The method was applied to a submarine spring at Stoupa Bay covering all seasons. The estimated residence time exhibited an annual mean of 4.6±1.7 d. An additional measurement using the in situ underwater γ-spectrometry technique was performed, in the same site. The in situ method yielded a value of 2.8±0.2 d that was found consistent with the corresponding value derived using the developed lab-based method (3...
December 18, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27990667/clinical-correlates-of-benefit-from-radium-223-therapy-in-metastatic-castration-resistant-prostate-cancer
#15
Ajjai Alva, Luke Nordquist, Stephanie Daignault, Saby George, Jorge Ramos, Costantine Albany, Sudhir Isharwal, Matthew McDonald, Gregory Campbell, Pongwut Danchaivijitr, Sarah Yentz, Aseem Anand, Evan Y Yu
BACKGROUND: We sought to identify potential clinical variables associated with outcomes after radium-223 therapy in routine practice. METHODS: Consecutive non-trial mCRPC patients who received ≥1 dose of radium dichloride-223 at four academic and one community urology-specific cancer centers from May 2013 to June 2014 were retrospectively identified. Association of baseline and on-therapy clinical variables with number of radium doses received and clinical outcomes including overall survival were analyzed using chi-square statistics, cox proportional hazards, and Kaplan-Meier methods...
December 19, 2016: Prostate
https://www.readbyqxmd.com/read/27987465/determination-of-low-level-radium-isotope-activities-in-fresh-waters-by-gamma-spectrometry
#16
Arnold Molina Porras, Michel Condomines, Jean Luc Seidel
A new portable sampling system was developed to extract Radium isotopes from large volumes (up to 300L) of fresh surface- and ground-waters of low Ra-activities (<5mBq/L). Ra is quantitatively adsorbed on a small amount (6.5g) of MnO2-coated acrylic fibers, which are then dried and burned at 600°C in the laboratory. The resulting Mn-oxide powder (about 2cm(3) when compacted) is then analyzed through gamma-ray spectrometry which allows measurement of the whole Ra quartet ((226)Ra, (228)Ra, (224)Ra and (223)Ra) in a single counting of a few days...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27984708/a-primary-standard-source-of-radon-222-based-on-the-hpge-detector
#17
M Y A Mostafa, M Vasyanovich, M Zhukovsky
The present paper describes the prototype of a calibration standard system for radon concentrations to be used in establishing the traceability of radon concentration measurements in dwellings. Radon gas was generated with a radium-226 solid source in a certified volume as a closed system. The activity of the radon that was released in the closed system was determined from the difference between the absolute activity of the standard radium solid source and the residual radon decay products ((214)Bi or (214)Pb)...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27965987/assessment-of-natural-radioactivity-levels-and-radiation-hazards-in-agricultural-and-virgin-soil-in-the-state-of-kedah-north-of-malaysia
#18
Ghazwa Alzubaidi, Fauziah B S Hamid, I Abdul Rahman
The activity concentrations of naturally occurring radionuclides (226)Ra, (232)Th, and (40)K were determined in 30 agricultural and virgin soil samples randomly collected from Kedah, north of Malaysia, at a fertile soil depth of 0-30 cm. Gamma-ray spectrometry was applied using high-purity germanium (HPGe) gamma-ray detector and a PC-based MCA. The mean radioactivity concentrations of (226)Ra, (232)Th, and (40)K were found to be 102.08 ± 3.96, 133.96 ± 2.92, and 325.87 ± 9.83 Bq kg(-1), respectively, in agricultural soils and 65...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27939081/environmental-signatures-and-effects-of-an-oil-and-gas-wastewater-spill-in-the-williston-basin-north-dakota
#19
I M Cozzarelli, K J Skalak, D B Kent, M A Engle, A Benthem, A C Mumford, K Haase, A Farag, D Harper, S C Nagel, L R Iwanowicz, W H Orem, D M Akob, J B Jaeschke, J Galloway, M Kohler, D L Stoliker, G D Jolly
Wastewaters from oil and gas development pose largely unknown risks to environmental resources. In January 2015, 11.4ML (million liters) of wastewater (300g/L TDS) from oil production in the Williston Basin was reported to have leaked from a pipeline, spilling into Blacktail Creek, North Dakota. Geochemical and biological samples were collected in February and June 2015 to identify geochemical signatures of spilled wastewaters as well as biological responses along a 44-km river reach. February water samples had elevated chloride (1030mg/L) and bromide (7...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27930924/effect-of-radium-223-dichloride-ra-223-on-hospitalisation-an-analysis-from-the-phase-3-randomised-alpharadin-in-symptomatic-prostate-cancer-patients-alsympca-trial
#20
Christopher Parker, Lin Zhan, Paul Cislo, Jonathan Reuning-Scherer, Nicholas J Vogelzang, Sten Nilsson, Oliver Sartor, Joe M O'Sullivan, Robert E Coleman
Symptomatic skeletal events (SSEs) commonly occur in patients with bone metastases, often leading to hospitalisations and decreased quality-of-life. In the ALSYMPCA trial, radium-223 significantly improved overall survival (hazard ratio 0.70, 95% confidence interval [CI] 0.58-0.83, P < 0.001) and prolonged time to first SSE (hazard ratio 0.66, 95% CI 0.52-0.83, P = 0.00037) and subsequent SSE (hazard ratio 0.65, 95% CI 0.51-0.83, P = 0.00039) versus placebo in patients with castration-resistant prostate cancer with symptomatic bone metastases and no known visceral metastases...
January 2017: European Journal of Cancer
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