keyword
MENU ▼
Read by QxMD icon Read
search

radium

keyword
https://www.readbyqxmd.com/read/28822315/applications-of-radon-and-radium-isotopes-to-determine-submarine-groundwater-discharge-and-flushing-times-in-todos-os-santos-bay-brazil
#1
Vanessa Hatje, Karina Kammer Attisano, Marcelo Friederichs Landim de Souza, Barbara Mazzilli, Joselene de Oliveira, Tamires de Araújo Mora, William C Burnett
Todos os Santos Bay (BTS) is the 2nd largest bay in Brazil and an important resource for the people of the State of Bahia. We made measurements of radon and radium in selected areas of the bay to evaluate if these tracers could provide estimates of submarine groundwater discharge (SGD) and flushing times of the Paraguaçu Estuary and BTS. We found that there were a few areas along the eastern and northeastern shorelines that displayed relatively high radon and low salinities, indicating possible sites of enhanced SGD...
August 16, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28812304/management-of-castration-resistant-taxane-resistant-prostate-cancer
#2
Tomasz M Beer
Metastatic castration-resistant prostate cancer that is progressing despite docetaxel chemotherapy is difficult to treat and often aggressive. If not previously used, modern androgen signaling inhibitors have established clinical activity in this setting. Cabazitaxel and radium-223 have also been shown to extend survival in appropriately selected patients. Carboplatin-containing chemotherapy regimens have not been studied in randomized trials with a survival endpoint, but they have demonstrated activity in phase II trials and are occasionally considered in the post-docetaxel setting...
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28811573/simultaneous-separation-of-actinium-and-radium-isotopes-from-a-proton-irradiated-thorium-matrix
#3
Tara Mastren, Valery Radchenko, Allison Owens, Roy Copping, Rose Boll, Justin R Griswold, Saed Mirzadeh, Lance E Wyant, Mark Brugh, Jonathan W Engle, Francois M Nortier, Eva R Birnbaum, Kevin D John, Michael E Fassbender
A new method has been developed for the isolation of (223,224,225)Ra, in high yield and purity, from a proton irradiated (232)Th matrix. Herein we report an all-aqueous process using multiple solid-supported adsorption steps including a citrate chelation method developed to remove >99.9% of the barium contaminants by activity from the final radium product. A procedure involving the use of three columns in succession was developed, and the separation of (223,224,225)Ra from the thorium matrix was obtained with an overall recovery yield of 91 ± 3%, average radiochemical purity of 99...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797482/-principles-modalities-and-indications-of-the-administration-of-radium-in-cancers-focus-on-metastatic-prostate-cancer-state-of-arts
#4
REVIEW
Pauline Bertolaso, Laura Leroy, Marine Gross-Goupil, Olivier Aupee, Alain Ravaud, Guilhem Roubaud, Anne-Laure Cazeau, Sylvestre Le Moulec
Prostate cancer is the first cancer in men and has a specific tropism to bones. This tropism provided the rationale to develop bone targeting radiopharmaceutical agents, such as strontium, samarium and more recently the Radium-223, an alpha-emitter. In a phase III trial, ALSYMPCA, Radium-223 not only improved pain relief, but also impacted on overall survival. Despite an approval by both FDA and EMA, prescription of this agent remains limited by the lack of refund, especially in France. Radium-223 is currently evaluated in several clinical trials (combination with chemotherapy, radiotherapy or hormone therapy) in order to optimize the therapeutic sequences in metastatic bone prostate cancer and argues for being incorporated into the current therapeutic arsenal...
August 7, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28793169/the-legacy-of-the-radium-girls
#5
David E Cohen, Randie H Kim
No abstract text is available yet for this article.
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28776193/calculating-the-radiological-parameters-used-in-non-human-biota-dose-assessment-tools-using-erica-tool-and-site-specific-data
#6
Maria Sotiropoulou, Heleny Florou, Georgios Kitis
The substantial complexity in ecosystem-radionuclide interactions is difficult to be represented in terms of radiological doses. Thus, radiological dose assessment tools use typical exposure situations for generalized organisms and ecosystems. In the present study, site-specific data and radioactivity measurements of terrestrial organisms (grass and herbivore mammals) and abiotic components (soil) are provided. The retrieved data are used in combination with the ERICA Assessment Tool for calculation of radiological parameters...
August 3, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28770408/phase-ii-study-of-radium-223-dichloride-in-japanese-patients-with-symptomatic-castration-resistant-prostate-cancer
#7
Nobuaki Matsubara, Satsohi Nagamori, Yoshiaki Wakumoto, Hirotsugu Uemura, Go Kimura, Akira Yokomizo, Hiroaki Kikukawa, Atsushi Mizokami, Takeo Kosaka, Naoya Masumori, Yoshihide Kawasaki, Junji Yonese, Yasutomo Nasu, Satoshi Fukasawa, Takayuki Sugiyama, Seigo Kinuya, Makoto Hosono, Iku Yamaguchi, Hirokazu Tsutsui, Hiroji Uemura
BACKGROUND: Radium-223 dichloride (radium-223) is the first targeted alpha therapy approved for the treatment of castration-resistant prostate cancer (CRPC) with bone metastases. This study investigated the efficacy and safety of radium-223 in Japanese patients with symptomatic CRPC and bone metastases. METHODS: In this open-label, multicenter, phase II study, patients with progressive, symptomatic CRPC and bone metastases were treated with radium-223 (55 kBq/kg, intravenously) in a 4-week cycle for six cycles...
August 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28760388/baseline-evaluation-for-natural-radioactivity-level-and-radiological-hazardous-parameters-associated-with-processing-of-high-grade-monazite
#8
E M El Afifi, A M Shahr El-Din, R F Aglan, E H Borai, M M Abo-Aly
Egyptian monazite is a promising resource and investment attractive for production of valuable metals of industrial or nuclear interest such as rare earth elements (REEs), thorium (Th) and uranium (U). The study was focused to establish a baseline framework in viewpoint of radiation protection for the workers in production of REEs from high-grade monazite treated by sodium hydroxide (NaOH) solutions. Radiological hazard indices (cancer, gonadal and other risks) were evaluated, due to emissions (α-, β- and γ-radiations) of radium-isotopes ((228)Ra, (226)Ra, (223)Ra) and lead ((210)Pb)...
July 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28756597/treatments-for-metastatic-prostate-cancer-mpc-a-review-of-costing-evidence
#9
REVIEW
Jan Norum, Carsten Nieder
BACKGROUND: Prostate cancer (PC) is the most common cancer in Western countries. More than one third of PC patients develop metastatic disease, and the 5-year expected survival in distant disease is about 35%. During the last few years, new treatments have been launched for metastatic castrate-resistant prostate cancer (mCRPC). OBJECTIVES: We aimed to review the current literature on health economic analysis on the treatment of metastatic prostate cancer (mPC), compare the studies, summarize the findings and make the results available to administrators and decision makers...
July 29, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28738252/radioactivity-analysis-of-soil-samples-taken-from-the-western-and-northern-shores-of-lake-van-turkey
#10
Halime Kayakökü, Mahmut Doğru
In this study, concentrations of the radioactive isotopes (226)Ra, (232)Th, (40)K and (137)Cs were measured in soil samples from the shores of Lake Van using a high purity germanium detector. Activity concentrations obtained for these nuclides were compared with world average values. The average (226)Ra, (232)Th and (4)(0)K activity concentrations calculated for the soil samples were higher than the world average values reported by UNSCEAR. The lowest (226)Ra, (232)Th and (4)(0)K activity concentrations were recorded in sample T-1 whereas the highest values were recorded in sample T-11...
July 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28724245/radioactively-hot-particles-detected-in-dusts-and-soils-from-northern-japan-by-combination-of-gamma-spectrometry-autoradiography-and-sem-eds-analysis-and-implications-in-radiation-risk-assessment
#11
Marco Kaltofen, Arnie Gundersen
After the March 11, 2011, nuclear reactor meltdowns at Fukushima Dai-ichi, 180 samples of Japanese particulate matter (dusts and surface soils) and 235 similar U.S. and Canadian samples were collected and analyzed sequentially by gamma spectrometry, autoradiography, and scanning electron microscopy with energy dispersive X-ray analysis. Samples were collected and analyzed over a five-year period, from 2011 to 2016. Detectable levels of (134)Cs and (137)Cs were found in 142 of 180 (80%) Japanese particulate matter samples...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28723476/charting-recent-progress-and-challenges-in-metastatic-castration-resistant-prostate-cancer-is-there-an-optimal-treatment-sequence
#12
REVIEW
Stéphane Oudard, Pablo Maroto, Gaston Demonty, Winald R Gerritsen
CONTEXT: Recent developments in the treatment of metastatic castration-resistant prostate cancer (mCRPC) have led to uncertainty about the optimal sequence of agents. OBJECTIVE: To review and assess treatment options and sequence in patients with mCRPC. EVIDENCE ACQUISITION: To identify data on the optimal use of approved treatments, we searched PubMed for studies on the use of recently approved agents for men with mCRPC published before March 2015...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28711312/radium-223-in-the-therapeutic-sequence-of-metastatic-castration-resistant-prostate-cancer
#13
M Unda-Urzaiz, R Sousa-Campo, A Rodríguez-Antolín, C Silva-Marins, A Juárez-Soto, B Miñana-López, A Figueiredo-de Castro, J M Cozar-Olmos
CONTEXT: Radium-223 is an □ -particle transmitter with specific action on bone metastases. The Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) study showed that radium-223 extended overall survival and delayed the onset of bone events in patients with symptomatic castration-resistant prostate cancer with bone metastases (mCRPC) and without visceral metastases, with a good safety profile. OBJECTIVE: To review the new scientific evidence on radium-223 based on prespecified and post-hoc analyses of the ALSYMPCA study and on early-access programs after the publication of the ALSYMPCA study, thereby providing new data on the management of patients with mCRPC...
July 12, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28705540/three-year-safety-of-radium-223-dichloride-in-patients-with-castration-resistant-prostate-cancer-and-symptomatic-bone-metastases-from-phase-3-randomized-alpharadin-in-symptomatic-prostate-cancer-trial
#14
Christopher C Parker, Robert E Coleman, Oliver Sartor, Nicholas J Vogelzang, David Bottomley, Daniel Heinrich, Svein I Helle, Joe M O'Sullivan, Sophie D Fosså, Aleš Chodacki, Paweł Wiechno, John Logue, Mihalj Seke, Anders Widmark, Dag Clement Johannessen, Peter Hoskin, Nicholas D James, Arne Solberg, Isabel Syndikus, Jan Kliment, Steffen Wedel, Sibylle Boehmer, Marcos Dall'Oglio, Lars Franzén, Øyvind S Bruland, Oana Petrenciuc, Karin Staudacher, Rui Li, Sten Nilsson
BACKGROUND: In Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial, radium-223 versus placebo prolonged overall survival with favorable safety in castration-resistant prostate cancer patients with symptomatic bone metastases. Long-term radium-223 monitoring underlies a comprehensive safety and risk/benefit assessment. OBJECTIVE: To report updated ALSYMPCA safety, including long-term safety up to 3 yr after the first injection. DESIGN, SETTING, AND PARTICIPANTS: Safety analyses from phase 3 randomized ALSYMPCA trial included patients receiving ≥1 study-drug injection (600 radium-223 and 301 placebo)...
July 10, 2017: European Urology
https://www.readbyqxmd.com/read/28700990/oncologic-response-and-hospitalization-rate-of-patients-receiving-cabazitaxel-in-the-fourth-line-and-beyond-in-castration-resistant-prostate-cancer-analysis-of-a-retrospective-cohort-and-a-structured-literature-review
#15
Jost von Hardenberg, Maike Schwartz, Thorsten Werner, Stefan Fuxius, Arne Strauss, Thomas Stefan Worst, Philipp Nuhn, Christian Bolenz, Elmar Heinrich
BACKGROUND: Limited data are available for the use of agents in metastatic castration-resistant prostate cancer (mCRPC) beyond the third-line. We provide data during treatment with cabazitaxel (CAB), helping to improve the informed-consent process. PATIENTS AND METHODS: We retrospectively reviewed patients treated with fourth-line or beyond CAB for mCRPC after failure of previous therapies with docetaxel, abiraterone acetate, enzalutamide and/or radium-223. The progression-free survival (PFS) and the overall survival (OS) were estimated using the Kaplan-Meier method and compared to published data based on a structured literature review...
July 13, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28689881/comparison-of-radium-228-determination-in-water-among-australian-laboratories
#16
Atun Zawadzki, Megan Cook, Brodie Cutmore, Fiona Evans, Daniela Fierro, Alicea Gedz, Jennifer J Harrison, Tom Loosz, Peter Medley, Lida Mokhber-Shahin, Sarah Mullins, Sandra Sdraulig
The National Health and Medical Research Council and Natural Resource Management Ministerial Council of Australia developed the current Australian Drinking Water Guidelines which recommend an annual radiation dose value of 1 mSv year(-1). One of the potential major contributors to the radiation dose from drinking water is radium-228, a naturally occurring radionuclide arising from the thorium decay series. Various methods of analysing for radium-228 in water have been established and adapted by analytical radiochemistry laboratories...
July 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28681295/is-high-indoor-radon-concentration-correlated-with-specific-activity-of-radium-in-nearby-soil-a-study-in-kosovo-and-metohija
#17
Ljiljana Gulan, Jelena M Stajic, Francesco Bochicchio, Carmela Carpentieri, Gordana Milic, Dragoslav Nikezic, Zora S Zunic
This paper presents indoor radon concentrations and specific activities of natural radionuclides measured in soils of Kosovo and Metohija. The measurements of radon concentration were performed during two consecutive 6-month periods in two rooms of 63 houses using CR-39 detectors. The annual radon concentration ranged from 30 to 810 Bq m(-3) with the average value of 128 Bq m(-3). Almost 15% of the houses had radon concentration higher than 200 Bq m(-3). The difference between radon concentrations measured in the two 6-month periods was analyzed, showing, as expected, a slightly higher radon concentration in the "winter period" than in the "summer period"...
July 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28677577/targeted-radionuclide-therapy-in-combined-modality-regimens
#18
REVIEW
Martin R Gill, Nadia Falzone, Yong Du, Katherine A Vallis
Targeted radionuclide therapy (TRT) is a branch of cancer medicine concerned with the use of radioisotopes, radiolabelled molecules, nanoparticles, or microparticles that either naturally accumulate in or are designed to target tumours. TRT combines the specificity of molecular and sometimes physical targeting with the potent cytotoxicity of ionising radiation. Targeting vectors for TRT include antibodies, antibody fragments, proteins, peptides, and small molecules. The diversity of available carrier molecules, together with the large panel of suitable radioisotopes with unique physicochemical properties, allows vector-radionuclide pairings to be matched to the molecular, pathological, and physical characteristics of a tumour...
July 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28663235/immunotherapy-of-prostate-cancer-facts-and-hopes
#19
Marijo Bilusic, Ravi A Madan, James L Gulley
In the last few years immunotherapy has become an important cancer treatment modality and while the principles of immunotherapy evolved over many decades, the FDA approvals of sipuleucel-T and ipilimumab began a new wave in immuno-oncology. Despite the current enthusiasm, it is unlikely that any of the immunotherapeutics alone can dramatically change prostate cancer outcomes, but combination strategies are more promising and provide a reason for optimism. Several completed and ongoing studies have shown that the combination of cancer vaccines or checkpoint inhibitors with different immunotherapeutic agents, hormonal therapy (enzalutamide), radiation therapy (radium 223), DNA-damaging agents (olaparib), or chemotherapy (docetaxel) can enhance immune responses and induce more dramatic, long-lasting clinical responses without significant toxicity...
June 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28654303/imaging-and-dosimetry-for-radium-223-the-potential-for-personalized-treatment
#20
Glenn D Flux
Radium-223 ((223)Ra) offers a new option for the treatment of bone metastases from prostate cancer. As cancer treatment progresses towards personalization, the potential for an individualized approach is exemplified in treatments with radiotherapeutics due to the unique ability to image in vivo the uptake and retention of the therapeutic agent. This is unmatched in any other field of medicine. Currently, (223)Ra is administered according to standard fixed administrations, modified according to patient weight...
June 27, 2017: British Journal of Radiology
keyword
keyword
30748
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"