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https://www.readbyqxmd.com/read/29036340/226ra-222rn-and-permeability-of-belgian-soils-in-relation-with-indoor-radon-risk
#1
C Licour, F Tondeur, I Gerardy, N Medaghri Alaoui, N Dubois, R Perreaux, N Gerardy, D Christiaens
Knowing the concentration of 226Ra in soil and of 222Rn in soil gas is important for the analysis of indoor radon data and the prediction of radon-prone areas. Except for soil Rn in Ardenne, the data concerning these two radionuclides in Belgian soils are very scarce. In the context of Master theses and international courses, students made 92 measurements of 226Ra in soil samples, 105 of 222Rn in soil gas, and 74 of soil permeability, a significant addition to the existing similar data. The data are analysed in relation with soil texture, geological units and indoor radon risk...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29035267/coastal-ocean-and-shelf-sea-biogeochemical-cycling-of-trace-elements-and-isotopes-lessons-learned-from-geotraces
#2
REVIEW
Matthew A Charette, Phoebe J Lam, Maeve C Lohan, Eun Young Kwon, Vanessa Hatje, Catherine Jeandel, Alan M Shiller, Gregory A Cutter, Alex Thomas, Philip W Boyd, William B Homoky, Angela Milne, Helmuth Thomas, Per S Andersson, Don Porcelli, Takahiro Tanaka, Walter Geibert, Frank Dehairs, Jordi Garcia-Orellana
Continental shelves and shelf seas play a central role in the global carbon cycle. However, their importance with respect to trace element and isotope (TEI) inputs to ocean basins is less well understood. Here, we present major findings on shelf TEI biogeochemistry from the GEOTRACES programme as well as a proof of concept for a new method to estimate shelf TEI fluxes. The case studies focus on advances in our understanding of TEI cycling in the Arctic, transformations within a major river estuary (Amazon), shelf sediment micronutrient fluxes and basin-scale estimates of submarine groundwater discharge...
November 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29027074/uptake-of-radium-223-dichloride-and-early-18-f-naf-pet-response-are-driven-by-baseline-18-f-naf-parameters-a-pilot-study-in-castration-resistant-prostate-cancer-patients
#3
Arthur Letellier, Alison C Johnson, Nicolas How Kit, Jean-François Savigny, Alain Batalla, Jean-Jacques Parienti, Nicolas Aide
PURPOSE: The purpose of this study is to identify predictive factors on baseline [(18)F]NaF positron emission tomography (PET)/computed tomography (CT) of early response to radium-223 dichloride after 3 cycles of treatment in metastatic castration-resistant prostate cancer patients. PROCEDURES: Analysis of 152 metastases was performed in six consecutive patients who underwent [(18)F]NaF PET/CT at baseline and for early monitoring after 3 cycles of radium-223 dichloride...
October 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29026946/psma-targeted-radioligandtherapy-in-metastatic-castration-resistant-prostate-cancer-after-chemotherapy-abiraterone-and-or-enzalutamide-a-retrospective-analysis-of-overall-survival
#4
K Rahbar, M Boegemann, A Yordanova, M Eveslage, M Schäfers, M Essler, H Ahmadzadehfar
AIM: Our aim was to evaluate overall survival and parameters prognosticating longer survival in a large and homogeneous group of patients treated with (177)Lu-PSMA-617 radioligand therapy with heavily pretreated advanced metastatic castration resistant prostate cancer. METHODS: A total of 104 patients were treated with 351 cycles of (177)Lu-PSMA-617. Prostate specific antigen (PSA) changes after the first cycle of therapy were documented prior to a second cycle...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29022046/-radium-223-dichloride-in-patients-with-castration-refractory-prostate-cancer
#5
REVIEW
B M Winter, F-C von Rundstedt, M-O Grimm
Since November 2013, the alpha emitter radium-223 dichloride (Alpharadin/Xofigo®) has been approved for the treatment of men with castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. In the ASYMPCA clinical trial, radium-223 was shown to improve overall survival and to reduce the time to the first symptomatic skeletal event. The use of radium-223 was associated with a reduction of pain and an improvement of health-related quality of life compared to the placebo arm...
October 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28982052/radionuclides-as-natural-tracers-of-the-interaction-between-groundwater-and-surface-water-in-the-river-andarax-spain
#6
Francisco Navarro-Martinez, Alejandro Salas Garcia, Francisco Sánchez-Martos, Antonio Baeza Espasa, Luis Molina Sánchez, Antonio Rodríguez Perulero
The identification of specific aquifers that supply water to river systems is fundamental to understanding the dynamics of the rivers' hydrochemistry, particularly in arid and semiarid environments where river flow may be discontinuous. There are multiple methods to identify the source of river water. In this study of the River Andarax, in the Southeast of Spain, an analysis of natural tracers (physico-chemical parameters, uranium, radium and radon) in surface water and groundwater indicates that chemical parameters and uranium clearly identify the areas where there is groundwater-surface water interaction...
October 2, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28981796/assessment-of-radium-activity-concentration-and-radon-exhalation-rates-in-iberian-peninsula-building-materials
#7
E Andrade, C Miró, M Reis, M Santos, M J Madruga
Radium (226Ra) is a natural radioactive element of the uranium decay series, which could also be present in building materials. Radon (222Rn) is continuously produced by the decay of 226Ra and its presence inside buildings can contribute to the increase of the population exposure to ionizing radiation. In this work, the amount of radium activity concentration and radon exhalation rates in several types of building materials that are commonly used in the Iberian Peninsula have been tested. The radium activity concentration was measured by gamma-ray spectrometry, whereas the radon exhalation rates were carried out using a continuous radon monitor (active measuring technique) and a solid state nuclear track detectors (passive measuring technique)...
September 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28981756/consequences-of-using-home-made-radon-sources-for-measuring-the-radon-diffusion-coefficient
#8
T Dobrovolný, M Jiránek
The applicability of home-made radon sources for determining the radon diffusion coefficient of waterproofing materials was studied for three representatives of materials with a high radium content: uraninite, slag concrete and filter sand. The results of our investigation confirmed that the radon production rate of home-made radon sources is significantly lower than the radon production rate of artificial sources. Consequently, home-made sources are usually unable to generate concentrations higher than 100 kBq/m3 in the source container...
September 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28975586/impact-of-treatment-delay-in-radium-223-therapy-of-metastatic-castration-resistant-prostate-cancer-patients
#9
Marie Øbro Fosbøl, Peter Meidahl Petersen, Gedske Daugaard, Søren Holm, Andreas Kjaer, Jann Mortensen
BACKGROUND: Radium-223-dichloride (Ra-223) is an alpha-emitting, bone seeking radionuclide therapy approved for patients with metastatic castration-resistant prostate cancer (mCRPC). In the fall of 2014, a global temporary shortage of Ra-223 occurred for 2 months due to production irregularities. The aim of this study was to assess whether prolonged interval between Ra-223 cycles to non-disease related causes had a negative impact on clinical outcome of therapy. MATERIALS AND METHODS: Retrospective single-center study of mCRPC patients who initiated Ra-223 therapy in the period from March 2014 to February 2015...
October 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28973919/unexpected-source-of-fukushima-derived-radiocesium-to-the-coastal-ocean-of-japan
#10
Virginie Sanial, Ken O Buesseler, Matthew A Charette, Seiya Nagao
There are 440 operational nuclear reactors in the world, with approximately one-half situated along the coastline. This includes the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), which experienced multiple reactor meltdowns in March 2011 followed by the release of radioactivity to the marine environment. While surface inputs to the ocean via atmospheric deposition and rivers are usually well monitored after a nuclear accident, no study has focused on subterranean pathways. During our study period, we found the highest cesium-137 ((137)Cs) levels (up to 23,000 Bq⋅m(-3)) outside of the FDNPP site not in the ocean, rivers, or potable groundwater, but in groundwater beneath sand beaches over tens of kilometers away from the FDNPP...
October 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28966451/usefulness-of-radium-223-in-patients-with-bone-metastases
#11
REVIEW
Nishant Gupta, Arushi Devgan, Itisha Bansal, Thomas D Olsavsky, Shuo Li, Ahmed Abdelbaki, Yogesh Kumar
Castration-resistant prostate osseous metastases can be challenging to treat. There is a new era of clinical advancement with the Food and Drug Administration approval of radium-223 for use in these patients. Radium-223 is the only clinically used therapeutic radiopharmaceutical that emits alpha particles, making it extremely safe for therapeutic purposes for the patient as well as close contacts. This review discusses radium-223's mechanism of action, pharmacokinetics, indications, and safety profile, as well as findings of concluded clinical trials...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28961839/re-treatment-with-radium-223-first-experience-from-an-international-open-label-phase-i-ii-study-in-patients-with-castration-resistant-prostate-cancer-and-bone-metastases
#12
O Sartor, D Heinrich, N Mariados, M J Méndez Vidal, D Keizman, C Thellenberg Karlsson, A Peer, G Procopio, S J Frank, K Pulkkanen, E Rosenbaum, S Severi, J M Trigo Perez, V Wagner, R Li, L T Nordquist
Background: Six radium-223 injections at 4-week intervals is indicated for patients with castration-resistant prostate cancer and symptomatic bone metastases. However, patients usually develop disease progression after initial treatment. This prospective phase I/II study assessed re-treatment safety and efficacy of up to six additional radium-223 injections. Patients and methods: Patients had castration-resistant prostate cancer and bone metastases and six initial radium-223 injections with no on-treatment bone progression; all had subsequent radiologic or clinical progression...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28949940/optimal-use-of-radium-223-in-patients-with-metastatic-castration-resistant-prostate-cancer
#13
Daniel J George
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28942327/influence-of-grain-size-on-radionuclide-activity-concentrations-and-radiological-hazard-of-building-material-samples
#14
Sahar Elnobi, S Harb, N K Ahmed
The knowledge of radioactivity content in various radionuclides in building materials plays an important role in health physics; therefore, we measured the amount of naturally occurring radionuclides in building material (sand, granite, marble, and limestone) samples of different grain sizes by using NaI (Tl) and MCA1024 gamma-ray spectrometers. Data analyses were performed to determine (226)Ra, (232)Th, and (4)°K activity concentrations. The results revealed an inverse relationship between activity concentration and grain size of the samples...
September 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28942321/geological-and-hydrogeochemical-controls-on-radium-isotopes-in-groundwater-of-the-sinai-peninsula-egypt
#15
Mahmoud I Sherif, Jiajia Lin, Armen Poghosyan, Abdou Abouelmagd, Mohamed I Sultan, Neil C Sturchio
Radium isotopes ((226)Ra and (228)Ra) were analyzed in 18 groundwater samples from the Nubian Sandstone Aquifer System (NSAS) and the shallow alluvial aquifers overlying the basement complex of the Sinai Peninsula, Egypt. Groundwater samples from deep Nubian aquifer wells (total depths 747 to 1250m) have (226)Ra and (228)Ra activities ranging from 0.168 to 0.802 and 0.056 to 1.032Bq/L, respectively. The shallower Nubian aquifer wells (63 to 366m) have (226)Ra and (228)Ra activities ranging from 0.033 to 0.191 and 0...
September 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28930600/line-1-as-a-therapeutic-target-for-castration-resistant-prostate-cancer
#16
Nadine Houede, Pier Vincenzo Piazza, Philippe Pourquier
Prostate cancer is the third leading cause of death by cancer in men. Surgery or hormone deprivation usually contains the progression of the local forms of the disease. In metastatic situations, chemotherapy or second generation hormone therapies are used with an overall survival that never exceeds 36 months when tumors become resistant to castration. In the search for new alternatives, clinical trials with various classes of anticancer drugs have been performed, including chemotherapies, targeted therapies with kinase inhibitors, radium-223, or immunotherapies with somehow limited efficacy...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28923125/why-we-write-nuclear-history
#17
David K Hecht
Nuclear history always compels. Scholars (and readers) can immerse themselves in the existential threat posed by the atomic bomb and its successor weapons, the tantalizing prospect of carbon-free energy, or the study of a natural phenomenon deeply at odds with our everyday experience of the world. There is thus always something profound at stake when we write nuclear history - be it physical, economic or intellectual. And while it may seem that the end of the Cold War should have diminished the academic attention accorded to the subject, it actually just allowed the historiography to evolve...
September 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28919714/radium-223-dichloride-for-prostate-cancer-treatment
#18
REVIEW
Emmanuel Deshayes, Mathieu Roumiguie, Constance Thibault, Philippe Beuzeboc, Florent Cachin, Christophe Hennequin, Damien Huglo, François Rozet, Diana Kassab-Chahmi, Xavier Rebillard, Nadine Houédé
Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo(®)) is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichloride has been approved for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases, without known visceral metastases...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28895676/maria-sk%C3%A5-odowska-curie-her-life-and-work-the-150-anniversary-of-her-birthday
#19
Małgorzata M. Dobrzyńska
Maria Skłodowska was born on November 7, 1867 in Warsaw (Poland). Her parents were teachers. Maria’s mother has died in 1878 of tuberculosis. In 1893 and 1894, respectively, Maria was awarded master’s degrees in physics and in mathematics from the Sorbonne University. In 1895 Maria married Pierre Curie. In 1897 their daughter Irene was born. Maria investigated rays emitted by uranium salts. She hypothesized that the radiation come from atom and called this phenomenon “radioactivity”. In 1898, Maria and Pierre discovered new radioactive elements polonium and radium...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28866822/dutch-economic-value-of-radium-223-in-metastatic-castration-resistant-prostate-cancer
#20
Michel L Peters, Claudine de Meijer, Dirk Wyndaele, Walter Noordzij, Annemarie M Leliveld-Kors, Joan van den Bosch, Pieter H van den Berg, Agni Baka, Jennifer G Gaultney
BACKGROUND: The treatment of metastatic castration-resistant prostate cancer has changed with the introduction of radium-223, cabazitaxel, abiraterone and enzalutamide. To assess value for money, their cost effectiveness in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel from the Dutch societal perspective was investigated. METHODS: A cost-effectiveness analysis was conducted using efficacy, symptomatic skeletal-related event and safety data obtained from indirect treatment comparisons...
September 2, 2017: Applied Health Economics and Health Policy
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