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https://www.readbyqxmd.com/read/28318331/docetaxel-chemotherapy-in-metastatic-castration-resistant-prostate-cancer-cost-of-care-in-medicare-and-commercial-populations
#1
A Armstrong, C Bui, K Fitch, T Goss Sawhney, B Brown, S Flanders, M Balk, J Deangelis, J Chambers
OBJECTIVE: To estimate the healthcare costs and characteristics of docetaxel chemotherapy episodes of care for men with metastatic castration-resistant prostate cancer (mCRPC). METHODS: We used Medicare 5% sample and MarketScan® Commercial (2010 - 2013) claims data sets to identify men with mCRPC and initial episodes of docetaxel treatment. Docetaxel episodes included docetaxel claim costs from the first claim until 30 days after the last claim, with earlier termination for death, insurance disenrollment, or the end of a 24-month look-forward period from initial docetaxel index date...
March 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28297744/a-permanent-multilevel-monitoring-and-sampling-system-in-the-coastal-groundwater-mixing-zones
#2
Xin Luo, King Lun Kwok, Yi Liu, Jimmy Jiao
To study the spatial and temporal variability of water dynamics and chemical reactions within the coastal groundwater mixing zones (CGMZs), high-resolution periodical and spatial groundwater sampling within CGMZs is needed. However, current samplers and sampling systems may require heavy driving machines to install. There is also possible contamination from the metal materials for current samplers and sampling systems. Here, a permanent multilevel sampling system is designed to sample coastal groundwater within CGMZs...
March 15, 2017: Ground Water
https://www.readbyqxmd.com/read/28285086/rapid-determination-of-radium-224-226-in-seawater-sample-by-alpha-spectrometry
#3
Lijuan Song, Yonggang Yang, Maoyi Luo, Yan Ma, Xiongxin Dai
A new radiochemical separation method has been developed for rapid determination of alpha-emitting radium isotopes in seawater samples. This method can be applied for the measurement of (226)Ra in seawater samples when (224)Ra is used as tracer for chemical recovery correction. Likewise, (226)Ra can also be added as tracer for the determination of (224)Ra in seawater sample. In the method, radium is first pre-concentrated with hydrous titanium oxide (HTiO) and is purified by combined anion/cation exchange column chromatographic separation...
March 8, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28276897/computational-modeling-of-radiobiological-effects-in-bone-metastases-for-different-radionuclides
#4
Francisco D C Guerra Liberal, Adriana Alexandre S Tavares, João Manuel R S Tavares
PURPOSE: Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. METHODS: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 ((89)Sr), Samarium-153 ((153)Sm), Lutetium-177 ((177)Lu), and Radium-223 ((223)Ra)...
March 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28244493/imaging-response-during-therapy-with-radium-223-for-castration-resistant-prostate-cancer-with-bone-metastases-analysis-of-an-international-multicenter-database
#5
D Keizman, M O Fosboel, H Reichegger, A Peer, E Rosenbaum, M-C Desax, V Neiman, P M Petersen, J Mueller, R Cathomas, M Gottfried, H Dresler, D Sarid, W Mermershtain, K Rouvinov, J Mortensen, S Gillessen, G Daugaard, A Omlin
BACKGROUND: The imaging response to radium-223 therapy is at present poorly described. We aimed to describe the imaging response to radium-223 treatment. METHODS: We retrospectively evaluated the computed tomography (CT) and bone scintigraphy response of metastatic castration-resistant prostate cancer (CRPC) patients treated with radium-223, in eight centers in three countries. RESULTS: A total of 130 patients were included, the majority (n=84, 65%) received radium-223 post docetaxel...
February 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28240735/universal-expositions-physics-chemistry-and-new-occupational-diseases-the-case-of-marie-sklodowska-curie-and-radium-girls
#6
Silvana Salerno
BACKGROUND: Radium discovery by Marie and Pierre Curies caused previously unknown diseases. Marie Sklodowska Curie (1867-1934) suffered from radiations effects, as did girls in the radium dial watches factories. Therapeutic effects of radium were soon discovered, its unhealthy effects were as yet unheard of. OBJECTIVES: Analysis of Marie Sklodowska Curie (Marie) and radium girls occupational exposure, taking scientific debate on radium dangerous effects into account...
February 15, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28238171/using-a-relative-health-indicator-rhi-metric-to-estimate-health-risk-reductions-in-drinking-water
#7
Katherine A Alfredo, Chad Seidel, Amlan Ghosh, J Alan Roberson
When a new drinking water regulation is being developed, the USEPA conducts a health risk reduction and cost analysis to, in part, estimate quantifiable and non-quantifiable cost and benefits of the various regulatory alternatives. Numerous methodologies are available for cumulative risk assessment ranging from primarily qualitative to primarily quantitative. This research developed a summary metric of relative cumulative health impacts resulting from drinking water, the relative health indicator (RHI). An intermediate level of quantification and modeling was chosen, one which retains the concept of an aggregated metric of public health impact and hence allows for comparisons to be made across "cups of water," but avoids the need for development and use of complex models that are beyond the existing state of the science...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28235699/long-term-changes-in-the-concentration-of-radium-in-discharge-waters-of-coal-mines-and-upper-silesian-rivers
#8
Stanisław Chałupnik, Małgorzata Wysocka, Ewa Janson, Izabela Chmielewska, Marta Wiesner
According to the latest guidelines of the International Atomic Energy Agency (IAEA, 2016), coal mining is one of the most important contributors to occupational exposure. Coal mining contributes about 45% of the total annual collective dose obtained by workers due to the exposure at places of working. One of the sources of exposure in mining are formation brines with elevated concentrations of natural radionuclides, the most common are radium (226)Ra and (228)Ra. Radium isotopes often occur in formation waters in underground collieries in the Upper Silesian region (USCB) in Poland...
February 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28221966/annual-effective-dose-of-gamma-emitters-in-adults-and-children-for-some-types-of-rice-consumed-in-iraq
#9
Ali Abid Abojassim, Dahir Mohammad Dahir, Azhar S Alaboodi, Abbas H Abonasria
This work studies the activity concentration of natural radioactivity in 20 different types of rice, including imported rice and that produced locally. The rice samples were collected from markets and farms in Iraq, and then a natural radioactivity investigation was done in the environmental laboratory of the Kufa University, using gamma-ray spectrometer systems. The research focused on measuring the activity concentration of natural radioactivity ((238)U, (232)Th, and (40)K) to determine the level of the radium equivalent activity, internal hazard indices, and annual effective dose...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28211289/radium-and-the-secret-of-life
#10
Nestor Herran
No abstract text is available yet for this article.
November 2016: Ambix
https://www.readbyqxmd.com/read/28207026/an-exploratory-analysis-of-alkaline-phosphatase-lactate-dehydrogenase-and-prostate-specific-antigen-dynamics-in-the-phase-3-alsympca-trial-with-radium-223
#11
O Sartor, R E Coleman, S Nilsson, D Heinrich, S I Helle, J M O'Sullivan, N J Vogelzang, Ø Bruland, S Kobina, S Wilhelm, L Xu, M Shan, M W Kattan, C Parker
No abstract text is available yet for this article.
February 16, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28185462/-options-of-chemotherapy-in-the-treatment-of-prostate-cancer
#12
I Richter, J Dvořák, J Bartoš
BACKGROUND: Prostate cancer is one of the most common malignancies in men. Chemotherapy has an important role in the management of prostate cancer, especially for the treatment of castrate resistant prostate cancer (mCRPC). According to recently published studies, chemotherapy can also be used to treat advanced hormone sensitive disease. AIM: The aim of this report is to review the currently available options for chemotherapy of prostate cancer. RESULTS: Docetaxel is a chemotherapeutic agent used for standard treatment of mCRPC as 1st line therapy...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28169118/bone-health-and-bone-targeted-therapies-for-prostate-cancer-a-programme-in-evidence-based-care-cancer-care-ontario-clinical-practice-guideline
#13
S M H Alibhai, K Zukotynski, C Walker-Dilks, U Emmenegger, A Finelli, S C Morgan, S J Hotte, E Winquist
AIMS: To make recommendations with respect to bone health and bone-targeted therapies in men with prostate cancer. MATERIALS AND METHODS: A systematic review was carried out by searching MEDLINE, EMBASE and the Cochrane Library from inception to January 2016. Systematic reviews and randomised-controlled trials were considered for inclusion if they involved therapies directed at improving bone health or outcomes such as skeletal-related events, pain and quality of life in patients with prostate cancer either with or without metastases to bone...
February 3, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28161102/residual-radioactivity-of-treated-green-diamonds
#14
Philippe Cassette, Franck Notari, Marie-Christine Lépy, Candice Caplan, Sylvie Pierre, Thomas Hainschwang, Emmanuel Fritsch
Treated green diamonds can show residual radioactivity, generally due to immersion in radium salts. We report various activity measurements on two radioactive diamonds. The activity was characterized by alpha and gamma ray spectrometry, and the radon emanation was measured by alpha counting of a frozen source. Even when no residual radium contamination can be identified, measurable alpha and high-energy beta emissions could be detected. The potential health impact of radioactive diamonds and their status with regard to the regulatory policy for radioactive products are discussed...
January 29, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28156633/evaluation-of-the-palliative-benefit-and-toxicity-of-ra-223-treatment-of-men-with-hormone-refractory-prostate-cancer-in-a-community-setting
#15
Bide Xiong, Fang Liu, Elizabeth Garber, James Wheeler
225 Background: The ALSYMCA (Alpharadin in Symptomatic Prostate Cancer) trial was a phase III, placebo controlled, randomized trial in which 921 men with bone metastasis from hormone refractory prostate cancer (HRPC) were randomly assigned to receive radium-223 (Ra-223) or placebo. Ra-223 produced a 30% survival benefit, with a median survival of 14.9 months compared to 11.3 months for patients treated with a placebo, which led to FDA approval in 2013. METHODS: We identified through the nuclear medicine records 11 patients who started Ra-223 between March 15, 2013 and December 10, 2015...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28140788/100-years-of-radiation-research-in-the-footsteps-of-failla
#16
Eric J Hall
Gioacchino Failla was initially appointed to operate the radon plant at Memorial Hospital in 1916. What to most people would have been a part-time temporary position was to him a career. He was not satisfied to simply fabricate radon seeds, he wanted to understand the physics and biology of the radiation emitted by the progeny of radium. His was not the first medical physics group in the United States, though it was one of the earliest, but it was the first to put such emphasis on the biological effects. After more than 28 years at Memorial Hospital, Failla moved his research group to Columbia University Medical Center and his pioneering work, blending physics and biology, has continued to date at Columbia by those that he trained or inspired, under three directors that followed him...
January 31, 2017: Radiation Research
https://www.readbyqxmd.com/read/28134027/radiological-impact-assessment-to-the-environment-due-to-waste-from-disposal-of-porcelain
#17
Tarek Morsi, Rehab Hegazy, Wael Badawy
The present study aims to assess the radiological parameters from gamma rays due to the uncontrolled disposal of porcelain waste to the environment. Qualitative and quantitative identification of radionuclides in the investigated samples was carried out by means of High-Purity Germanium (HPGe) detector. The average activity concentrations of the local porcelain samples were measured as 208.28 Bq/kg for (226)Ra, 125.73 Bq/kg for (238)U, 84.94 Bq/kg for (232)Th and 1033.61 Bq/kg for (40)K, respectively...
January 30, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28131809/rapid-assessment-methodology-in-norm-measurements-from-building-materials-of-uzbekistan
#18
A A Safarov, A N Safarov, A N Azimov, I G Darby
Utilizing low cost NaI(Tl) scintillation detector systems we present methodology for the rapid screening of building material samples and the determination of their Radium Equivalent Activity (Raeq). Materials from Uzbekistan as a representative developing country have been measured and a correction coefficient for Radium activity is deduced. The use of the correction coefficient offers the possibility to decrease analysis times thus enabling the express measurement of a large quantity of samples. The reduction in time, cost and the use of inexpensive equipment can democratize the practice of screening NORM in building materials in the international community...
January 26, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28127143/focal-cutaneous-squamous-cell-carcinoma-following-radium-223-extravasation
#19
Katie E Benjegerdes, Shannon C Brown, Chad D Housewright
Long-term sequelae due to extravasation of intravenous radioisotopes resulting in radiation injuries are rarely reported. As the use of radioactive isotopes for the treatment of osteoblastic metastases increases, information regarding the prevention, treatment, and long-term monitoring of suspected extravasation injury will become increasingly important. We present a patient with no previous history of skin cancer who developed an aggressive cutaneous squamous cell carcinoma at the site of prior radium-223 extravasation...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28125362/duration-of-treatment-in-prostate-cancer-patients-treated-with-abiraterone-acetate-or-enzalutamide
#20
Dominic Pilon, Ajay S Behl, Lorie A Ellis, Bruno Emond, Patrick Lefebvre, Nancy A Dawson
BACKGROUND: Abiraterone acetate (AA) and enzalutamide (ENZ) are oral therapies offering survival benefit to metastatic castration-resistant prostate cancer (mCRPC) patients. Despite the availability of multiple treatment options for mCRPC, there is a lack of information on the effect that being initiated on AA or ENZ has on the combined prostate cancer treatment duration. OBJECTIVE: To compare the combined duration of prostate cancer treatments of patients initiated on AA with that of patients initiated on ENZ...
February 2017: Journal of Managed Care & Specialty Pharmacy
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