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Dongfeng-Tongji cohort

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https://www.readbyqxmd.com/read/29696820/genetic-correction-of-serum-afp-level-improves-risk-prediction-of-primary-hepatocellular-carcinoma-in-the-dongfeng-tongji-cohort-study
#1
Ke Wang, Yansen Bai, Shi Chen, Jiao Huang, Jing Yuan, Weihong Chen, Ping Yao, Xiaoping Miao, Youjie Wang, Yuan Liang, Xiaomin Zhang, Meian He, Handong Yang, Huan Guo, Sheng Wei
Serum alpha-fetoprotein (AFP) is the most commonly used tumor biomarker for screening and diagnosis of primary hepatocellular carcinoma (HCC). However, the predictive effect for HCC risk is still unsatisfactory. The aim of this prospective study was to estimate whether the individual genetic correction could improve the prediction efficiency of AFP for HCC risk. A prospective analysis with 9819 baseline HCC-free individuals based on a large population-based Chinese cohort study was performed. Two single-nucleotide polymorphisms (SNPs) associated with serum AFP level were used to calculate the genetic corrected AFP level (rs12506899 and rs2251844)...
April 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29693425/metabolic-syndrome-is-associated-with-hearing-loss-among-a-middle-aged-and-older-chinese-population-a-cross-sectional-study
#2
Xu Han, Zhichao Wang, Jing Wang, Yaru Li, Hua Hu, Yujuan Hu, Xueyan Zhao, Yue Zhan, Jing Yuan, Sheng Wei, Yuan Liang, Xiaomin Zhang, Huan Guo, Handong Yang, Tangchun Wu, Weijia Kong, Meian He
BACKGROUND: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this association in a Chinese population. METHODS: A cross-sectional study including a total of 18,824 middle-aged and older participants from the Dongfeng-Tongji Cohort study was conducted. Hearing loss was defined as the pure-tone average (PTA) of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 decibels hearing level (dB HL) in the better ear and graded as mild (PTA 26-40 dB HL), moderate (PTA >40 to ≤60 dB HL), and severe (PTA >60 dB HL)...
April 25, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29651306/association-of-mean-platelet-volume-with-incident-type-2-diabetes-mellitus-risk-the-dongfeng-tongji-cohort-study
#3
Zhaoyang Li, Jing Wang, Xu Han, Jing Yuan, Huan Guo, Xiaomin Zhang, Dan Zheng, Yuhan Tang, Handong Yang, Meian He
Background: Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population. Methods: This prospective study included 14,009 individuals derived from the Dongfeng-Tongji cohort which was launched in 2008...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29625350/victims-of-chinese-famine-in-early-life-have-increased-risk-of-metabolic-syndrome-in-adulthood
#4
Caizheng Yu, Jing Wang, Fei Wang, Xu Han, Hua Hu, Jing Yuan, Xiaoping Miao, Ping Yao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Dan Zheng, Yuhan Tang, Handong Yang, Tangchun Wu, Meian He
OBJECTIVES: To investigate the association of exposure to the Chinese famine during early life with metabolic syndrome risk in adults. METHODS: There were 7,915 participants from Dongfeng-Tongji cohort were included in the present study. Participants were classified as non-exposed group, fetal exposed group, early childhood-, mid childhood-, and late childhood-exposed groups, respectively. Metabolic syndrome was defined according to International Diabetes Foundation criteria (2005)...
February 5, 2018: Nutrition
https://www.readbyqxmd.com/read/29546576/history-of-spontaneous-miscarriage-and-the-risk-of-diabetes-mellitus-among-middle-aged-and-older-chinese-women
#5
Bingqing Liu, Lulu Song, Hui Li, Xiaoxuan Zheng, Jing Yuan, Yuan Liang, Youjie Wang
AIMS: Epidemiological studies of the long-term maternal health outcomes of spontaneous miscarriages have been sparse and inconsistent. The objective of our study is to examine the association between spontaneous miscarriages and diabetes among middle-aged and older Chinese women. METHODS: A total of 19,539 women from the Dongfeng-Tongji cohort study who completed a questionnaire and had medical examinations performed on were included in the analysis. History of spontaneous miscarriage was obtained by self-reporting in the first follow-up questionnaire interview...
June 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29477559/hearing-loss-is-associated-with-increased-chd-risk-and-unfavorable-chd-related-biomarkers-in-the-dongfeng-tongji-cohort
#6
Qin Fang, Zhichao Wang, Yue Zhan, Dan Li, Kun Zhang, Tao Zhou, Handong Yang, Ce Zhang, Xiulou Li, Xinwen Min, Weihong Chen, Huan Guo, Mei-An He, Weijia Kong, Tangchun Wu, Xiaomin Zhang
BACKGROUND AND AIMS: The association between hearing loss and coronary heart disease (CHD) is inconsistent. We aimed to investigate the association of hearing loss with prevalent CHD and CHD-related biomarkers among a middle aged and elderly Chinese population. METHODS: We included 14,755 Chinese aged 64.6 years from the Dongfeng-Tongji Cohort in 2013. Hearing loss was classified into normal, mild, moderate or greater levels by the pure tone average (PTA) at low frequency and high frequency, respectively...
April 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29429611/associations-of-multiple-plasma-metals-with-incident-type-2-diabetes-in-chinese-adults-the-dongfeng-tongji-cohort
#7
Yu Yuan, Yang Xiao, Yanqiu Yu, Yiyi Liu, Wei Feng, Gaokun Qiu, Hao Wang, Bing Liu, Jing Wang, Lue Zhou, Kang Liu, Xuedan Xu, Handong Yang, Xiulou Li, Lu Qi, Xiaomin Zhang, Meian He, Frank B Hu, An Pan, Tangchun Wu
The long-term associations between multiple metals and incident diabetes are uncertain. We aimed to examine the relationship between plasma concentrations of 23 metals and the incidence of type 2 diabetes among Chinese senior adults. We quantified fasting plasma concentrations of 23 metals by inductively coupled plasma mass spectrometry among 1039 incident diabetes cases and 1039 controls (age and sex matched) nested in a prospective study, the Dongfeng-Tongji cohort. Both cases and controls were free of diabetes at baseline (2008-2010), incident diabetes were identified using the following criteria: fasting glucose ≥ 7...
June 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29337020/inverse-association-between-plasma-homocysteine-concentrations-and-type-2-diabetes-mellitus-among-a-middle-aged-and-elderly-chinese-population
#8
C Yu, J Wang, F Wang, X Han, H Hu, J Yuan, X Miao, P Yao, S Wei, Y Wang, Y Liang, W Chen, X Zhang, H Guo, H Yang, Y Tang, D Zheng, T Wu, M He
BACKGROUND AND AIMS: Plasma homocysteine concentrations have been reported to be associated with type 2 diabetes mellitus (T2DM) with controversial findings. The aim of the present study was to investigate the association between plasma homocysteine concentrations and T2DM. METHODS AND RESULTS: A cross-sectional study including 19,085 eligible participants derived from the Dongfeng-Tongji cohort was conducted. Plasma homocysteine concentrations were measured by Abbott Architect i2000 Automatic analyzer and T2DM was defined according to American Diabetes Association criteria...
March 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29221783/the-effect-of-sleep-duration-and-sleep-quality-on-hypertension-in-middle-aged-and-older-chinese-the-dongfeng-tongji-cohort-study
#9
Dongming Wang, Yun Zhou, Yanjun Guo, Runbo Zhang, Wenzhen Li, Meian He, Xiaomin Zhang, Huan Guo, Jing Yuan, Tangchun Wu, Weihong Chen
OBJECTIVE: To examine the independent and combined associations of sleep duration and sleep quality with hypertension in a middle-aged and older Chinese population. METHODS: We included 21,912 individuals aged 62.2 years at baseline from September 2008 to June 2010, and they were followed until October 2013. Sleep duration was self-reported and sleep quality was evaluated with questions designed according to the Pittsburgh Sleep Quality Index. Hypertension was defined as blood pressure ≥140/90 mmHg, or self-reported physician diagnosis of hypertension, or self-reported current use of antihypertensive medication...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29199092/occupational-noise-exposure-and-hypertension-the-dongfeng-tongji-cohort-study
#10
Dongming Wang, Min Zhou, Wenzhen Li, Weijia Kong, Zhichao Wang, Yanjun Guo, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen
The association between occupational noise exposure and hypertension is unclear. We aimed to explore the association in a Chinese population and to summarize our findings with previous published articles. The cross-sectional study included 22,450 participants from Dongfeng-Tongji Cohort Study. In a subsample of 10,636 subjects, we assessed the association between hearing loss and hypertension. For the meta-analysis, we searched PubMed and EMBASE until April 2017, and the pooled odds ratio (OR) was combined using a random effect model...
February 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29064788/plasma-metal-concentrations-and-incident-coronary-heart-disease-in-chinese-adults-the-dongfeng-tongji-cohort
#11
Yu Yuan, Yang Xiao, Wei Feng, Yiyi Liu, Yanqiu Yu, Lue Zhou, Gaokun Qiu, Hao Wang, Bing Liu, Kang Liu, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Chengwei Xu, Xiaomin Zhang, Meian He, Frank B Hu, An Pan, Tangchun Wu
BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex...
October 19, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29036996/-analysis-of-prevalence-and-related-factors-of-osteoporosis-in-retired-population-based-on-dongfeng-tongji-cohort
#12
H Yan, X Z Liu, Y Z Zhang, M A He, T C Wu
Objective: To investigate the prevalence and related factors of osteoporosis among retired population in Dongfeng-Tongji cohort. Methods: 27 009 retired participants were recruited from Dongfeng Motor Corporation in Hubei Province in 2008 and followed up from April to October in 2013. newly retired participants also were recruited. Data were collected by using questionnaire, physical examination, serum hepatase detection and bone densitometry. Totally, 30 916 participants were included for data analysis after excluding participants with severe bone metabolic diseases, taking hormone drugs, incomplete follow-up data and who were under 45 years old...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29036995/-association-of-alcohol-use-and-incidence-of-type-2-diabetes-mellitus-in-the-middle-aged-and-elderly-male-population-a-prospective-cohort-study
#13
Y Z Zhang, Y Q Yu, Y Yuan, M A He, T C Wu
Objective: To investigate the association between alcohol use and incidence of type 2 diabetes mellitus (T2DM) in the middle-aged and elderly male population. Methods: All participants were from Dongfeng-Tongji cohort, 27 009 retired employees from Dongfeng Motor Corporation in Hubei Province were enrolled in the Dongfeng-Tongji cohort baseline survey in 2008. In baseline study, information of alcohol use and other covariates were collected by semi-structured questionnaire and all participants completed physical examination including the test of fasting glucose and blood lipid levels...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29028277/associations-between-daily-cooking-duration-and-the-prevalence-of-diabetes-and-prediabetes-in-a-middle-aged-and-elderly-chinese-population-a-cross-sectional-study
#14
F Wang, J Wang, Y Li, X Han, H Hu, C Yu, J Yuan, P Yao, X Miao, S Wei, Y Wang, W Chen, Y Liang, H Guo, X Zhang, H Yang, T Wu, M He
Experimental and epidemiological studies indicated that ambient air pollution was positively associated with diabetes. Few studies investigated the associations between household air pollution, for example, daily cooking duration and diabetes or prediabetes. We conducted a cross-sectional study to investigate the associations of daily cooking duration with the prevalence of diabetes and prediabetes among a middle-aged and elderly population. A total of 26 089 individuals (11 250 males and 14 839 females) derived from the Dongfeng-Tongji cohort study were included...
March 2018: Indoor Air
https://www.readbyqxmd.com/read/29016533/age-at-natural-menopause-and-hypertension-among-middle-aged-and-older-chinese-women
#15
Lulu Song, Lijun Shen, Hui Li, Bingqing Liu, Xiaoxuan Zheng, Lina Zhang, Yuan Liang, Jing Yuan, Youjie Wang
OBJECTIVES: Earlier age at natural menopause has been associated with cardiovascular disease in several studies, but evidence of its association with hypertension is lacking. We aimed to examine the relationship between age at natural menopause and hypertension among middle-aged and older Chinese women. METHODS: A total of 13 406 postmenopausal women (mean age 63.5 years) were enrolled from the Dongfeng-Tongji cohort study in Hubei province, China. Age at natural menopause was self-reported and was categorized into three groups (≤45, 46-52, or ≥53 years)...
March 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/28918462/development-of-a-new-scoring-system-to-predict-5-year-incident-diabetes-risk-in-middle-aged-and-older-chinese
#16
Xu Han, Jing Wang, Yaru Li, Hua Hu, Xiulou Li, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Tangchun Wu, Meian He
AIMS: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population. METHODS: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Incident diabetes was defined as self-reported clinician diagnosed diabetes, fasting glucose ≥7.0 mmol/l, or the use of insulin or oral hypoglycemic agent...
January 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/28894203/the-combined-effect-of-cigarette-smoking-and-occupational-noise-exposure-on-hearing-loss-evidence-from-the-dongfeng-tongji-cohort-study
#17
Dongming Wang, Zhichao Wang, Min Zhou, Wenzhen Li, Meian He, Xiaomin Zhang, Huan Guo, Jing Yuan, Yue Zhan, Kun Zhang, Tao Zhou, Weijia Kong, Weihong Chen
Combined effect of cigarette smoking and occupational noise exposure on hearing loss has rarely been evaluated among Chinese population, especially among females. This cross-sectional study was conducted in 11196 participants of Dongfeng-Tongji cohort study. Smoking status was self-reported through questionnaire and occupational noise exposure was evaluated through workplace noise level and/or the job titles. Hearing loss was defined as a pure-tone mean of 25 dB or higher at 0.5, 1, 2, and 4 kHz in both ears...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879775/direct-indirect-and-total-bilirubin-and-risk-of-incident-coronary-heart-disease-in-the-dongfeng-tongji-cohort
#18
Xuefeng Lai, Qin Fang, Liangle Yang, Xuguang Chen, Hao Wang, Lin Ma, Wenting Guo, Miao Liu, Handong Yang, Ce Zhang, Xiulou Li, Xinwen Min, Jing Yuan, Mei-An He, Tangchun Wu, Xiaomin Zhang
BACKGROUND: Total bilirubin (TBIL) is known to be inversely associated with coronary heart disease (CHD) risk, however, whether this association is dose-response remains inconsistent and it is unclear which subtype of bilirubin is responsible for the potential protective effect. METHODS: We included 12,097 participants who were free of CHD, stroke, cancer and potential liver, biliary and renal diseases at baseline from September 2008 to June 2010 and were followed-up until October 2013...
February 2018: Annals of Medicine
https://www.readbyqxmd.com/read/28855533/associations-of-estimated-glomerular-filtration-rate-and-blood-urea-nitrogen-with-incident-coronary-heart-disease-the-dongfeng-tongji-cohort-study
#19
Haijing Jiang, Jun Li, Kuai Yu, Handong Yang, Xinwen Min, Huanqian Chen, Tangchun Wu
Estimated glomerular filtration rate (eGFR) has been reported to be associated with risk of incident coronary heart disease (CHD), and blood urea nitrogen (BUN) has been shown to be a strong predictor of mortality in patients with heart failure (HF). However, such epidemiological evidence from Chinese population was still limited. We used Cox proportional-hazards regression models to investigate the associations of eGFR and BUN with risk of incident CHD in the prospective Dongfeng-Tongji (DFTJ) cohort. After fully adjusted for potential confounders, a 10-unit decline in eGFR was associated with higher risk for CHD (hazard ratio [HR] 1...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852192/the-cross-sectional-and-longitudinal-effect-of-hyperlipidemia-on-knee-osteoarthritis-results-from-the-dongfeng-tongji-cohort-in-china
#20
Min Zhou, Yanjun Guo, Dongming Wang, Da Shi, Weijin Li, Yuewei Liu, Jing Yuan, Meian He, Xiaomin Zhang, Huan Guo, Tangchun Wu, Weihong Chen
To quantify the cross-sectional and longitudinal effects of hyperlipidemia on knee osteoarthritis (KOA), we studied 13,906 middle-aged or older participants from the Dongfeng-Tongji cohort. Physical examinations were performed at baseline and follow-up. Knee pain was diagnosed by self-reported pain or stiffness. Clinical KOA was diagnosed from knee pain complains and clinical X-ray radiographs. The prevalence of knee pain and clinical KOA was 39.0% and 6.7% at baseline, respectively. Hyperlipidemia was associated with knee pain (OR 1...
August 29, 2017: Scientific Reports
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