Karolina Ferenc, Michał Marcinkowski, Jarosław Olszewski, Paweł Kowalczyk, Tomaš Pilžys, Damian Garbicz, Naser Dib, Bianka Świderska, Piotr Matyba, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
To reveal the sources of obesity and type 2 diabetes (T2D) in humans, animal models, mainly rodents, have been used. Here, we propose a pig model of T2D. Weaned piglets were fed high fat/high sugar diet suppling 150% of metabolizable energy. Measurements of weight gain, blood morphology, glucose plasma levels, cholesterol, and triglycerides, as well as glucose tolerance (oral glucose tolerance test, OGTT) were employed to observe T2D development. The histology and mass spectrometry analyses were made post mortem...
May 3, 2024: Scientific Reports