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https://www.readbyqxmd.com/read/29453893/cbct-guided-evolutive-library-for-cervical-adaptive-imrt
#1
Bastien Rigaud, Antoine Simon, Maxime Gobeli, Caroline Lafond, Julie Leseur, Anais Barateau, Nicolas Jaksic, Joël Castelli, Danièle Williaume, Pascal Haigron, Renaud De Crevoisier
PURPOSE: In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. MATERIAL AND METHODS: For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs (with empty [EB], intermediate [IB], and full [FB] bladder volumes), a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed...
February 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29436852/comparing-photon-and-proton-based-hypofractioned-sbrt-for-prostate-cancer-accounting-for-robustness-and-realistic-treatment-deliverability
#2
Lee Goddard, Nils P Brodin, William R Bodner, Madhur Garg, Wolfgang A Tomé
OBJECTIVE: To investigate whether photon or proton based SBRT is the preferred modality for high dose hypofractionation prostate cancer treatment. Achievable dose distributions were compared when uncertainties in target positioning and range uncertainties were appropriately accounted for. METHODS: Ten patients with prostate cancer previously treated at our institution with photon SBRT using volumetric modulated arc therapy (VMAT) were identified. MRI images fused to the treatment planning CT allowed for accurate target and organ-at-risk (OAR) delineation...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29419478/18f-fludarabine-pet-for-lymphoma-imaging-first-in-man-study-in-dlbcl-and-cll-patients
#3
Sylvain Chantepie, Narinée Hovhannisyan, Stéphane Guillouet, Jean-Pierre Pelage, Méziane Ibazizene, Caroline Bodet-Milin, Thomas Carlier, Anne-Claire Gac, Emilie Réboursière, Jean-Pierre Vilque, Françoise Kraeber-Bodéré, Alain Manrique, Gandhi Damaj, Michel Leporrier, Louisa Barré
This is the first in-man clinical study of 18F-fludarabine which is a radiopharmaceutical for PET imaging in lymphoma where many issues remain controversial with the standard radiotracer 18F-FDG. Methods:18F-Fludarabine-PET(/CT) was performed in 10 patients: five with diffuse large B-cell lymphoma (DLBCL) and five with chronic lymphocytic leukemia (CLL). The biodistribution, and radiation dosimetry of 18F-fludarabine have also been evaluated. Six successive partial body PET scans were acquired for 250 min after intravenous 4 MBq/kg bolus of 18F-fludarabine...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29416607/a-method-of-respiratory-phase-optimization-for-better-dose-sparing-of-organs-at-risks-a-validation-study-in-patients-with-lung-cancer
#4
Seong-Hee Kang, Siyong Kim, Dong-Su Kim, Tae-Ho Kim, So-Hyun Park, Dong-Seok Shin, Kyeong-Hyeon Kim, Min-Seok Cho, YeonSil Kim, Tae Suk Suh
Background: To propose an effective and simple cost value function to determine an optimal respiratory phase for lung treatment using either respiratory gating or breath-hold technique. Results: The optimized phase was obtained at a phase close to end inhalation in 11 out of 15 patients. For the rest of patients, the optimized phase was obtained at a phase close to end exhalation indicating that optimal phase can be patient specific. The mean doses of the Organs-at-risk (OARs) significantly decreased at the optimized phase without compromising the planning target volume (PTV) coverage (about 8% for all 3 OARs considered)...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29408780/role-of-radiotherapy-in-residual-pineal-parenchymal-tumors
#5
Narendra Kumar, Gulladamane Yogesh Srinivasa, Renu Madan, Pravin Salunke
OBJECTIVES: Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in residual PPT's. PATIENTS AND METHODS: Between 2006-2016, fourteen patients with residual PPT's were treated with adjuvant radiotherapy (12 with 3D conformal RT)...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29405123/prototype-volumetric-ultrasound-tomography-image-guidance-system-for-prone-stereotactic-partial-breast-irradiation-proof-of-concept
#6
Tsuicheng D Chiu, David Parsons, Yue Zhang, Brian Hrycushko, Bo Zhao, Rajiv Chopra, Nathan Kim, Ann Spangler, Asal Rahimi, Robert D Timmerman, Steve B Jiang, Weiguo Lu, Xuejun Gu
Accurate dose delivery in Stereotactic partial breast irradiation (S-PBI) is challenging because of the target position uncertainty caused by breast deformation, the target volume changes caused by lumpectomy cavity shrinkage, and target delineation uncertainty on simulation computed tomography (CT) images caused by poor soft tissue contrast. We have developed a volumetric ultrasound tomography (UST) image guidance system for prone position S-PBI. The system is composed of a novel 3D printed rotation water tank, a patient-specific resin breast immobilization cup, and a 1D array ultrasound transducer...
February 6, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29398127/carotid-dosimetry-and-the-risk-of-carotid-blowout-syndrome-after-reirradiation-with-head-and-neck-stereotactic-body-radiation-therapy
#7
Brian J Gebhardt, John A Vargo, Diane Ling, Brianna Jones, Mary Mohney, David A Clump, James P Ohr, Robert L Ferris, Dwight E Heron
PURPOSE: To correlate carotid dose and risk of carotid blowout syndrome (CBOS) after stereotactic body radiation therapy (SBRT), hypothesizing that carotid dose does not correlate with CBOS. METHODS AND MATERIALS: We retrospectively reviewed 186 patients with recurrent, previously irradiated head and neck cancer treated between January 2008 and March 2013. Patients treated early in our experience with incomplete dosimetry were excluded from analysis (n = 111). A total of 75 patients were identified, providing 150 carotid arteries for analysis...
December 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29397271/effectiveness-of-respiratory-gated-positron-emission-tomography-computed-tomography-for-radiotherapy-planning-in-patients-with-lung-carcinoma-a-systematic-review
#8
R Frood, R Prestwich, C Tsoumpas, P Murray, K Franks, A Scarsbrook
AIMS: A systematic review of the literature evaluating the clinical use of respiratory-gated (four-dimensional; 4D) fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) compared with non-gated (three-dimensional; 3D) PET/CT for radiotherapy planning in lung cancer. MATERIALS AND METHODS: A search of MEDLINE, Cochrane, Web of Science, SCOPUS and clinicaltrials.gov databases was undertaken for articles comparing 3D and 4D PET/CT tumour volume or 4D PET/CT for radiotherapy planning...
January 31, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29393179/irradiation-of-intracranial-gliomas-in-children
#9
Rolf-Dieter Kortmann, Clemens Seidel, Klaus Müller, Franz Wolfgang Hirsch
Attainment of local control is a cornerstone in the management of brain tumors in children. Treatment of progressive low-grade and all high-grade gliomas traditionally includes resection followed by fractionated radiotherapy (FRT) or FRT alone in neoplasms not amenable to surgical removal. While in younger children chemotherapy is typically used as a first-line non-surgical management option, FRT in such patients remains the standard of salvage therapy. Recent improvements in techniques for radiation treatment planning and delivery allow conformal and selective coverage of the target volume with a prescribed dose, sparing adjacent normal tissues to assure maximal tumor control and minimal toxicity...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29372876/the-impact-of-spine-disease-relative-to-cranial-disease-on-perception-of-health-and-care-experience-an-analysis-of-1484-patients-in-a-tertiary-center
#10
Panagiotis Kerezoudis, Mohammed Ali Alvi, Daniel S Ubl, Kristine T Hanson, William E Krauss, Fredric B Meyer, Robert J Spinner, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE Patient-reported outcomes have been increasingly mandated by regulators and payers to evaluate hospital and physician performance. The purpose of this study is to delineate the differences in patient-reported experience of hospital care for cranial and spinal operations. METHODS The authors selected all patients who underwent inpatient, elective cranial or spinal procedures and completed the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey at a single, high-volume, tertiary care institution between October 2012 and September 2015...
January 26, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29372873/a-novel-mesial-temporal-stereotactic-coordinate-system
#11
Kai J Miller, Casey H Halpern, Mark F Sedrak, John A Duncan, Gerald A Grant
OBJECTIVE Stereotactic laser ablation and neurostimulator placement represent an evolution in staged surgical intervention for epilepsy. As this practice evolves, optimal targeting will require standardized outcome measures that compare electrode lead or laser source with postprocedural changes in seizure frequency. The authors propose and present a novel stereotactic coordinate system based on mesial temporal anatomical landmarks to facilitate the planning and delineation of outcomes based on extent of ablation or region of stimulation within mesial temporal structures...
January 26, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29364211/pet-and-mri-guided-irradiation-of-a-glioblastoma-rat-model-using-a-micro-irradiator
#12
Julie Bolcaen, Benedicte Descamps, Tom Boterberg, Christian Vanhove, Ingeborg Goethals
For decades, small animal radiation research was mostly performed using fairly crude experimental setups applying simple single-beam techniques without the ability to target a specific or well-delineated tumor volume. The delivery of radiation was achieved using fixed radiation sources or linear accelerators producing megavoltage (MV) X-rays. These devices are unable to achieve sub-millimeter precision required for small animals. Furthermore, the high doses delivered to healthy surrounding tissue hamper response assessment...
December 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29351341/labeling-for-big-data-in-radiation-oncology-the-radiation-oncology-structures-ontology
#13
Jean-Emmanuel Bibault, Eric Zapletal, Bastien Rance, Philippe Giraud, Anita Burgun
PURPOSE: Leveraging Electronic Health Records (EHR) and Oncology Information Systems (OIS) has great potential to generate hypotheses for cancer treatment, since they directly provide medical data on a large scale. In order to gather a significant amount of patients with a high level of clinical details, multicenter studies are necessary. A challenge in creating high quality Big Data studies involving several treatment centers is the lack of semantic interoperability between data sources...
2018: PloS One
https://www.readbyqxmd.com/read/29348874/value-of-ct-mri-fusion-in-iodine-125-brachytherapy-for-high-grade-glioma
#14
Yang Gao, Yan Han, Guo Nan, Man Hu, Xiaobin Zhou, Xiaokun Hu
Purposes: To develop a fast, accurate and robust method of fusing Computed Tomography (CT) with pre-operative Magnetic Resonance Imaging (MRI) and evaluate the impact of using the fused data on the implantation of Iodine-125 (125I) seeds for brachytherapy of high-grade gliomas (HGG). Methods: A study was performed on a cohort of 10 consecutive patients with HGG were treated by 125I brachytherapy with CT-MRI fusion image guided (CMGB), and 10 patients treated with CT alone guided (CGB)...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29332453/mri-related-geometric-distortions-in-stereotactic-radiotherapy-treatment-planning-evaluation-and-dosimetric-impact
#15
Eleftherios P Pappas, Mukhtar Alshanqity, Argyris Moutsatsos, Hani Lababidi, Khalid Alsafi, Konstantinos Georgiou, Pantelis Karaiskos, Evangelos Georgiou
In view of their superior soft tissue contrast compared to computed tomography, magnetic resonance images are commonly involved in stereotactic radiosurgery/radiotherapy applications for target delineation purposes. It is known, however, that magnetic resonance images are geometrically distorted, thus deteriorating dose delivery accuracy. The present work focuses on the assessment of geometric distortion inherent in magnetic resonance images used in stereotactic radiosurgery/radiotherapy treatment planning and attempts to quantitively evaluate the consequent impact on dose delivery...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331573/deformable-image-registration-based-contour-propagation-yields-clinically-acceptable-plans-for-mri-based-cervical-cancer-brachytherapy-planning
#16
Christina Hunter Chapman, Daniel Polan, Karen Vineberg, Shruti Jolly, Katherine E Maturen, Kristy K Brock, Joann I Prisciandaro
PURPOSE: To study the dosimetric impact of deformable image registration-based contour propagation on MRI-based cervical cancer brachytherapy planning. METHODS AND MATERIALS: High-risk clinical target volume (HRCTV) and organ-at-risk (OAR) contours were delineated on MR images of 10 patients who underwent ring and tandem brachytherapy. A second set of contours were propagated using a commercially available deformable registration algorithm. "Manual-contour" and "propagated-contour" plans were optimized to achieve a maximum dose to the most minimally exposed 90% of the volume (D90) (%) of 6 Gy/fraction, respecting minimum dose to the most exposed 2cc of the volume (D2cc) OAR constraints of 5...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29330751/prospective-trial-evaluating-the-sensitivity-and-specificity-of-3-4-dihydroxy-6-18f-fluoro-l-phenylalanine-18f-dopa-pet-and-mri-in-patients-with-recurrent-gliomas
#17
Ryan S Youland, Deanna H Pafundi, Debra H Brinkmann, Val J Lowe, Jonathan M Morris, Bradley J Kemp, Christopher H Hunt, Caterina Giannini, Ian F Parney, Nadia N Laack
Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI in patients with recurrent glioma. Thirteen patients with MRI findings suspicious for recurrent glioma were prospectively enrolled and underwent 18F-DOPA-PET and MRI for neurosurgical planning. Stereotactic biopsies were obtained from regions of concordant and discordant PET and MRI CE, all within regions of T2/FLAIR signal hyperintensity...
January 13, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29306379/variation-assessment-of-deformable-registration-in-stereotactic-radiosurgery
#18
C-S Chang, R Shih, J-M Hwang, K-S Chuang
INTRODUCTION: The regular functions of CT-MRI registration include delineation of targets and organs-at-risk (OARs) in radiosurgery planning. The question of whether deformable image registration (DIR) could be applied to stereotactic radiosurgery (SRS) in its place remains a subject of debate. METHODS: This study collected data regarding 16 patients who had undergone single-fraction SRS treatment. All lesions were located close to the brainstem. CT and MRI two image sets were registered by both rigid image registration (RIR) and DIR algorithms...
February 2018: Radiography
https://www.readbyqxmd.com/read/29237965/investigating-different-computed-tomography-techniques-for-internal-target-volume-definition
#19
S A Yoganathan, K J Maria Das, V Siva Subramanian, D Gowtham Raj, Arpita Agarwal, Shaleen Kumar
PURPOSE: The aim of this work was to evaluate the various computed tomography (CT) techniques such as fast CT, slow CT, breath-hold (BH) CT, full-fan cone beam CT (FF-CBCT), half-fan CBCT (HF-CBCT), and average CT for delineation of internal target volume (ITV). In addition, these ITVs were compared against four-dimensional CT (4DCT) ITVs. MATERIALS AND METHODS: Three-dimensional target motion was simulated using dynamic thorax phantom with target insert of diameter 3 cm for ten respiration data...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#20
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
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