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Target volume delineation

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https://www.readbyqxmd.com/read/27908181/defining-and-assessing-an-anisotropic-delineation-margin-for-modern-radiotherapy
#1
L R Bell, E M Pogson, P E Metcalfe, L C Holloway
PURPOSE: Uncertainty in target volume delineation for modern radiotherapy impacts dosimetry and patient outcomes. Delineation uncertainty is generally overlooked in practice as a source of error, potentially since historically, other uncertainties have been the main focus. This work defined and assessed an anisotropic delineation margin in both polar and spherical coordinate systems in order to account for the spatially varying nature of this uncertainty using a whole breast radiotherapy cohort as a proof of concept...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27904452/virtual-modelling-of-novel-applicator-prototypes-for-cervical-cancer-brachytherapy
#2
Primoz Petric, Robert Hudej, Noora Al-Hammadi, Barbara Segedin
BACKGROUND: Standard applicators for cervical cancer Brachytherapy (BT) do not always achieve acceptable balance between target volume and normal tissue irradiation. We aimed to develop an innovative method of Target-volume Density Mapping (TDM) for modelling of novel applicator prototypes with optimal coverage characteristics. Patients and methods. Development of Contour-Analysis Tool 2 (CAT-2) software for TDM generation was the core priority of our task group. Main requests regarding software functionalities were formulated and guided the coding process...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27895682/development-and-clinical-implementation-of-a-new-template-for-mri-based-intracavitary-interstitial-gynecologic-brachytherapy-for-locally-advanced-cervical-cancer-from-ct-based-mupit-to-the-mri-compatible-template-benidorm-ten-years-of-experience
#3
Silvia Rodríguez Villalba, Jose Richart Sancho, Antonio Otal Palacín, Jose Perez-Calatayud, Manuel Santos Ortega
PURPOSE: To study outcome and toxicity in 59 patients with locally advanced cervix carcinoma treated with computed tomography (CT)-based Martinez universal perineal interstitial template (MUPIT) and the new magnetic resonance imaging (MRI)-compatible template Benidorm (TB). MATERIAL AND METHODS: From December 2005 to October 2015, we retrospectively analyzed 34 patients treated with MUPIT and 25 treated with the TB. Six 4 Gy fractions were prescribed to the clinical target volume (CTV) combined with external beam radiotherapy (EBRT)...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27887643/distribution-of-fdg-avid-nodes-in-esophageal-cancer-implications-for-radiotherapy-target-delineation
#4
Brandon Garcia, Karyn A Goodman, Lajhem Cambridge, Mark Dunphy, Abraham J Wu
PURPOSE: Clinical target volumes (CTV) for radiotherapy (RT) in esophageal cancer (EC) are based on standard expansions of primary tumor volume. Data is needed to define regions at highest risk for occult disease, based on histology and location of the primary tumor. We therefore reviewed PET scans in EC patients to characterize the location of FDG-avid lymph node metastases (LNM). MATERIALS AND METHODS: We identified 473 EC patients with reviewable pre-treatment PET-CT scans...
November 25, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27875103/diffusion-weighted-imaging-as-a-treatment-response-biomarker-for-evaluating-bone-metastases-in-prostate-cancer-a-pilot-study
#5
Raquel Perez-Lopez, Joaquin Mateo, Helen Mossop, Matthew D Blackledge, David J Collins, Mihaela Rata, Veronica A Morgan, Alison Macdonald, Shahneen Sandhu, David Lorente, Pasquale Rescigno, Zafeiris Zafeiriou, Diletta Bianchini, Nuria Porta, Emma Hall, Martin O Leach, Johann S de Bono, Dow-Mu Koh, Nina Tunariu
Purpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods A phase II prospective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCRPC included a prospective magnetic resonance (MR) imaging substudy; the study was approved by the institutional research board, and written informed consent was obtained...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27867039/peritoneal-dialysis-effluent-mir-21-and-mir-589-levels-correlate-with-longitudinal-change-in-peritoneal-transport-characteristics
#6
Cheuk-Chun Szeto, Kai-Ming Chow, Bonnie Ching-Ha Kwan, Phyllis Mei-Shan Cheng, Cathy Choi-Wan Luk, Jack Kit-Chung Ng, Man-Ching Law, Chi-Bon Leung, Philip Kam-Tao Li
BACKGROUND: The role of microRNA (miRNA) in peritoneal fibrosis and longitudinal change in transport is uncertain. METHODS: We studied 80 new peritoneal dialysis (PD) patients. Peritoneal transport was determined by standard peritoneal equilibration test (PET) of creatinine at baseline. Based on published literature, PD effluent levels of 10 miRNA targets were quantified. PET and miRNA quantification were repeated one year later in 46 patients. RESULTS: Baseline PD effluent levels of all targets tested had modest but significant correlation with peritoneal transport parameters...
November 17, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27863962/understanding-the-impact-of-pelvic-organ-motion-on-dose-delivered-to-target-volumes-during-imrt-for-cervical-cancer
#7
Gemma Eminowicz, Vasilis Rompokos, Christopher Stacey, Lisa Hall, Mary McCormack
BACKGROUND: Advanced radiotherapy techniques reduce normal tissue dose by conforming closely to target volumes. In cervical cancer radiotherapy, organ filling affects clinical target volume (CTV; cervix, uterus) position. This study estimates the dosimetric effect of this primary CTV position variation during chemoradiation. METHODS/MATERIALS: Twice weekly cone-beam computed tomography (CBCT) images of ten patients undergoing cervical chemoradiation were retrospectively analysed...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27846378/tumor-delineation-and-quantitative-assessment-of-glucose-metabolic-rate-within-histologic-subtypes-of-non-small-cell-lung-cancer-by-using-dynamic-18-f-fluorodeoxyglucose-pet
#8
Tineke W H Meijer, Lioe-Fee de Geus-Oei, Eric P Visser, Wim J G Oyen, Monika G Looijen-Salamon, Dimitris Visvikis, Ad F T M Verhagen, Johan Bussink, Dennis Vriens
Purpose To assess whether dynamic fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) has added value over static (18)F-FDG PET for tumor delineation in non-small cell lung cancer (NSCLC) radiation therapy planning by using pathology volumes as the reference standard and to compare pharmacokinetic rate constants of (18)F-FDG metabolism, including regional variation, between NSCLC histologic subtypes. Materials and Methods The study was approved by the institutional review board. Patients gave written informed consent...
November 15, 2016: Radiology
https://www.readbyqxmd.com/read/27843735/interhemispheric-difference-images-from-postoperative-diffusion-tensor-imaging-of-gliomas
#9
Robert Kosztyla, Stefan A Reinsberg, Vitali Moiseenko, Brian Toyota, Alan Nichol
Introduction Determining the full extent of gliomas during radiotherapy planning can be challenging with conventional T1 and T2 magnetic resonance imaging (MRI). The purpose of this study was to develop a method to automatically calculate differences in the fractional anisotropy (FA) and mean diffusivity (MD) values in target volumes obtained with diffusion tensor imaging (DTI) by comparing with values from anatomically homologous voxels on the contralateral side of the brain. Methods Seven patients with a histologically confirmed glioma underwent postoperative radiotherapy planning with 1...
October 5, 2016: Curēus
https://www.readbyqxmd.com/read/27829431/radiomics-based-targeted-radiotherapy-planning-rad-trap-a-computational-framework-for-prostate-cancer-treatment-planning-with-mri
#10
Rakesh Shiradkar, Tarun K Podder, Ahmad Algohary, Satish Viswanath, Rodney J Ellis, Anant Madabhushi
BACKGROUND: Radiomics or computer - extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomics along with deformable co-registration tools can be used to develop a framework to generate targeted focal radiotherapy treatment plans. METHODS: The Rad-TRaP framework comprises three distinct modules. Firstly, a module for radiomics based detection of PCa lesions on mpMRI via a feature enabled machine learning classifier...
November 10, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27823640/impact-of-pet-ct-on-radiation-treatment-in-patients-with-esophageal-cancer-a-systematic-review
#11
REVIEW
Jing Lu, Xiang-Dong Sun, Xi Yang, Xin-Yu Tang, Qin Qin, Hong-Cheng Zhu, Hong-Yan Cheng, Xin-Chen Sun
PURPOSE: With the advances in radiotracers, positron emission tomography/computed tomography (PET/CT) is recognized as a useful adjunct to anatomic imaging with CT, MRI and endoscopic ultrasonography (EUS). The objective of this review was to comprehensively analyze the roles of PET/CT for the radiotherapy of esophageal cancer. METHODS: In this review, we focused on issues concerning the application of PET/CT in TNM staging, target volume delineation and response to therapy, both for the primary tumor and regional lymph nodes...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27816363/patterns-of-primary-tumor-invasion-and-regional-lymph-node-spread-based-on-magnetic-resonance-imaging-in-early-stage-nasal-nk-t-cell-lymphoma-implications-for-clinical-target-volume-definition-and-prognostic-significance
#12
Run-Ye Wu, Kang Liu, Wei-Hu Wang, Jing Jin, Yong-Wen Song, Shu-Lian Wang, Yue-Ping Liu, Hua Ren, Hui Fang, Qing-Feng Liu, Yong Yang, Bo Chen, Shu-Nan Qi, Ning-Ning Lu, Yu Tang, Yuan Tang, Ning Li, Han Ouyang, Ye-Xiong Li
PURPOSE: This study aimed to determine the pathways of primary tumor invasion (PTI) and regional lymph node (LN) spread based on magnetic resonance imaging (MRI) in early-stage nasal NK/T-cell lymphoma (NKTCL), to improve clinical target volume (CTV) delineation and evaluate the prognostic value of locoregional extension patterns. METHODS AND MATERIALS: A total of 105 patients with newly diagnosed early-stage nasal NKTCL who underwent pretreatment MRI were retrospectively reviewed...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816360/does-peer-review-of-radiation-plans-affect-clinical-care-a-systematic-review-of-the-literature
#13
Kelsey Brunskill, Timothy K Nguyen, R Gabriel Boldt, Alexander V Louie, Andrew Warner, Lawrence B Marks, David A Palma
PURPOSE: Peer review is a recommended component of quality assurance in radiation oncology; however, it is resource-intensive and its effect on patient care is not well understood. We conducted a systematic review of the published data to assess the reported clinical impact of peer review on radiation treatment plans. METHODS AND MATERIALS: A systematic review of published English studies was performed in accordance with the PRISMA guidelines using the MEDLINE and EMBASE databases and abstracts published from major radiation oncology scientific meeting proceedings...
September 20, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27815039/standardisation-of-target-volume-delineation-for-carotid-sparing-intensity-modulated-radiotherapy-in-early-glottis-cancer
#14
D M Gujral, M Long, J W G Roe, K J Harrington, C M Nutting
AIMS: Recently, carotid-sparing intensity-modulated radiotherapy (IMRT) for early laryngeal glottis (T1/T2N0M0) cancer has generated interest in the hope of avoiding long-term carotid toxicity, as well as concerns relating to geographical misses and long-term normal tissue toxicity. The aim of this review was to summarise the current literature on carotid-sparing IMRT for early glottis cancer, with particular focus on definitions of target volumes and the carotid arteries as organs at risk...
November 1, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27811130/impact-of-neuroradiology-based-peer-review-on-head-and-neck-radiotherapy-target-delineation
#15
S Braunstein, C M Glastonbury, J Chen, J M Quivey, S S Yom
BACKGROUND AND PURPOSE: While standard guidelines assist in target delineation for head and neck radiation therapy planning, the complex anatomy, varying patterns of spread, unusual or advanced presentations, and high risk of treatment-related toxicities produce continuous interpretive challenges. In 2007, we instituted weekly treatment planning quality assurance rounds as a joint enterprise of head and neck radiation oncology and neuroradiology. Here we describe its impact on head and neck radiation therapy target delineation...
November 3, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27806589/real-time-4d-dose-reconstruction-for-tracked-dynamic-mlc-deliveries-for-lung-sbrt
#16
Cornelis Ph Kamerling, Martin F Fast, Peter Ziegenhein, Martin J Menten, Simeon Nill, Uwe Oelfke
PURPOSE: This study provides a proof of concept for real-time 4D dose reconstruction for lung stereotactic body radiation therapy (SBRT) with multileaf collimator (MLC) tracking and assesses the impact of tumor tracking on the size of target margins. METHODS: The authors have implemented real-time 4D dose reconstruction by connecting their tracking and delivery software to an Agility MLC at an Elekta Synergy linac and to their in-house treatment planning software (TPS)...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27806121/fully-automated-enhanced-tumor-compartmentalization-man-vs-machine-reloaded
#17
Nicole Porz, Simon Habegger, Raphael Meier, Rajeev Verma, Astrid Jilch, Jens Fichtner, Urspeter Knecht, Christian Radina, Philippe Schucht, Jürgen Beck, Andreas Raabe, Johannes Slotboom, Mauricio Reyes, Roland Wiest
OBJECTIVE: Comparison of a fully-automated segmentation method that uses compartmental volume information to a semi-automatic user-guided and FDA-approved segmentation technique. METHODS: Nineteen patients with a recently diagnosed and histologically confirmed glioblastoma (GBM) were included and MR images were acquired with a 1.5 T MR scanner. Manual segmentation for volumetric analyses was performed using the open source software 3D Slicer version 4.2.2.3 (www...
2016: PloS One
https://www.readbyqxmd.com/read/27788960/comparison-of-magnetic-resonance-imaging-and-computed-tomography-for-breast-target-volume-delineation-in-prone-and-supine-positions
#18
Elise M Pogson, Geoff P Delaney, Verity Ahern, Miriam M Boxer, Christine Chan, Steven David, Marion Dimigen, Jennifer A Harvey, Eng-Siew Koh, Karen Lim, George Papadatos, Mei Ling Yap, Vikneswary Batumalai, Elizabeth Lazarus, Kylie Dundas, Jesmin Shafiq, Gary Liney, Catherine Moran, Peter Metcalfe, Lois Holloway
PURPOSE: To determine whether T2-weighted MRI improves seroma cavity (SC) and whole breast (WB) interobserver conformity for radiation therapy purposes, compared with the gold standard of CT, both in the prone and supine positions. METHODS AND MATERIALS: Eleven observers (2 radiologists and 9 radiation oncologists) delineated SC and WB clinical target volumes (CTVs) on T2-weighted MRI and CT supine and prone scans (4 scans per patient) for 33 patient datasets. Individual observer's volumes were compared using the Dice similarity coefficient, volume overlap index, center of mass shift, and Hausdorff distances...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27788952/comparison-of-computed-tomography-and-magnetic-resonance-imaging-based-clinical-target-volume-contours-at-brachytherapy-for%C3%A2-cervical-cancer
#19
Cameron W Swanick, Katherine O Castle, Sastry Vedam, Mark F Munsell, Lehendrick M Turner, Gaiane M Rauch, Anuja Jhingran, Patricia J Eifel, Ann H Klopp
PURPOSE: We prospectively compared computed tomography (CT)- and magnetic resonance imaging (MRI)-based high-risk clinical target volume (HR-CTV) contours at the time of brachytherapy for cervical cancer in an effort to identify patients who might benefit most from MRI-based planning. METHODS AND MATERIALS: Thirty-seven patients who had undergone a pretreatment diagnostic MRI scan were included in the analysis. We delineated the HR-CTV on the brachytherapy CT and brachytherapy MRI scans independently for each patient...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27788948/analysis-of-lung-tumor-motion-in-a-large-sample-patterns-and-factors-influencing-precise-delineation-of-internal-target-volume
#20
Lukas Knybel, Jakub Cvek, Lukas Molenda, Natalie Stieberova, David Feltl
PURPOSE/OBJECTIVE: To evaluate lung tumor motion during respiration and to describe factors affecting the range and variability of motion in patients treated with stereotactic ablative radiation therapy. METHODS AND MATERIALS: Log file analysis from online respiratory tumor tracking was performed in 145 patients. Geometric tumor location in the lungs, tumor volume and origin (primary or metastatic), sex, and tumor motion amplitudes in the superior-inferior (SI), latero-lateral (LL), and anterior-posterior (AP) directions were recorded...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
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