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Target volume delineation

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https://www.readbyqxmd.com/read/28089481/recommendations-for-mri-based-contouring-of-gross-tumor-volume-and-organs-at-risk-for-radiation-therapy-of-pancreatic-cancer
#1
H D Heerkens, W A Hall, X A Li, P Knechtges, E Dalah, E S Paulson, C A T van den Berg, G J Meijer, E J Koay, C H Crane, K Aitken, M van Vulpen, B A Erickson
PURPOSE: Local recurrence is a common and morbid event in patients with unresectable pancreatic adenocarcinoma. A more conformal and targeted radiation dose to the macroscopic tumor in nonmetastatic pancreatic cancer is likely to reduce acute toxicity and improve local control. Optimal soft tissue contrast is required to facilitate delineation of a target and creation of a planning target volume with margin reduction and motion management. Magnetic resonance imaging (MRI) offers considerable advantages in optimizing soft tissue delineation and is an ideal modality for imaging and delineating a gross tumor volume (GTV) within the pancreas, particularly as it relates to conformal radiation planning...
October 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28079816/a-comparison-study-between-gross-tumor-volumes-defined-by-preoperative-magnetic-resonance-imaging-postoperative-specimens-and-tumor-bed-for-radiotherapy-after-breast-conserving-surgery
#2
Aiping Zhang, Jianbin Li, Wei Wang, Yongsheng Wang, Dianbin Mu, Zhaoqiu Chen, Qian Shao, Fengxiang Li
BACKGROUND: The identification and contouring of target volume is important for breast-conserving therapy. The aim of the study was to compare preoperative magnetic resonance imaging (MRI), postoperative pathology, excised specimens' (ES) size, and tumor bed (TB) delineation as methods for determining the gross tumor volume (GTV) for radiotherapy after breast-conserving surgery (BCS). METHODS: Thirty-three patients with breast cancer who underwent preoperative MRI and radiotherapy after BCS were enrolled...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078638/-11-c-methionine-positron-emission-tomography-delineates-non-contrast-enhancing-tumor-regions-at-high-risk-for-recurrence-in-pediatric-high-grade-glioma
#3
John T Lucas, Nick Serrano, Hyun Kim, Xingyu Li, Scott E Snyder, Scott Hwang, Yimei Li, Chia-Ho Hua, Alberto Broniscer, Thomas E Merchant, Barry L Shulkin
We assessed the prognostic utility of (11)C-Methionine positron emission tomography (MET-PET) in pediatric high-grade glioma (HGG). Thirty-one children had 62 MET-PET studies. Segmented tumor volumes from co-registered magnetic resonance studies were assessed for concordance with MET-PET uptake using Boolean operations. The tumor volume at diagnosis and treatment failure was assessed relative to MET-PET avid volume. The prognostic impact of MET-PET-delineated non-contrast enhancing tumor (NCET) was assessed...
January 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28072693/comparative-evaluation-of-target-volumes-defined-by-deformable-and-rigid-registration-of-diagnostic-pet-ct-to-planning-ct-in-primary-esophageal-cancer
#4
Yanluan Guo, Jianbin Li, Peng Zhang, Qian Shao, Min Xu, Yankang Li
BACKGROUND: To evaluate the geometrical differences of target volumes propagated by deformable image registration (DIR) and rigid image registration (RIR) to assist target volume delineation between diagnostic Positron emission tomography/computed tomography (PET/CT) and planning CT for primary esophageal cancer (EC). METHODS: Twenty-five patients with EC sequentially underwent a diagnostic F-fluorodeoxyglucose (F-FDG) PET/CT scan and planning CT simulation. Only 19 patients with maximum standardized uptake value (SUVmax) ≥ 2...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28048927/mo-fg-bra-05-dosimetric-and-radiobiological-validation-of-respiratory-gating-in-conventional-and-hypofractionated-radiotherapy-of-the-lung-effect-of-dose-dose-rate-gating-window-and-breathing-pattern
#5
L Cervino, D Soultan, N Pettersson, A Yock, M Cornell, J Aguilera, J Murphy, B Gill, S Advani, V Moiseenko
PURPOSE: to evaluate the dosimetric and radiobiological consequences from having different gating windows, dose rates, and breathing patterns in gated VMAT lung radiotherapy. METHODS: A novel 3D-printed moving phantom with central high and peripheral low tracer uptake regions was 4D FDG-PET/CT-scanned using ideal, patient-specific regular, and irregular breathing patterns. A scan of the stationary phantom was obtained as a reference. Target volumes corresponding to different uptake regions were delineated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048901/su-f-t-627-a-conformity-index-study-of-sbrt-plans-for-lung-cancer-patient
#6
Dengsong Zhu, Guoqing Fan, Chong Peng, Carlos Austerlitz
PURPOSE: To evaluate the conformity index for SBRT lung plan in Eclipse (version 11) treatment planning system. METHODS: In the Eclipse treatment planning system the conformity index was defined as VRI/TV, where VRI is prescription isodose surface, and TV is the target volume. In 1997, Van't Riet et al introduced TVRI/TV × TVRI/VRI as a conformal index, where TVRI is the target volume closed by the prescription isodose surface. We chose a lung cancer patient who was assigned to be treated with SBRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048897/su-f-j-156-the-feasibility-of-mr-only-imrt-planning-for-prostate-anatomy
#7
R Vaitheeswaran, K R Sivaramakrishnan, Prashant Kumar, Raja Gattamaneni, Girish Kumar
PURPOSE: For prostate anatomy, previous investigations have shown that simulated CT (sCT) generated from MR images can be used for accurate dose computation. In this study, we demonstrate the feasibility of MR-only IMRT planning for prostate case. METHODS: Regular CT (rCT) and MR images of the same patient were acquired for prostate anatomy. Regions-of-interest (ROIs) i.e. target and risk structures are delineated on the rCT. A simulated CT (sCT) is generated from the MR image using the method described by Schadewaldt N et al...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048869/su-f-j-145-mri-guided-interventional-boost-radiotherapy-for-rectal-cancer-investigating-the-feasibility-of-adapting-the-anatomy
#8
J J E Kleijnen, A M Couwenberg, B van Asselen, J J W Lagendijk, M Intven, B W Raaymakers
PURPOSE: The recent development of an MRI-linac allows adaptation of treatments to the anatomy of the moment. This anatomy, in turn, could be altered into a more favorable situation for radiotherapy purposes. The purpose of this study is to investigate the potential dosimetric benefits of manipulating rectal anatomy in MRI-guided interventional external-beam radiotherapy for rectal cancer. METHODS: For this retrospective analysis, four patients (1M/3F) diagnosed with rectal cancer were included...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048809/mo-d-brc-01-memorial-lecture
#9
B Fraass
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048786/mo-d-brc-04-multiple-criteria-optimization-planning
#10
J Donaghue
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048777/mo-e-brb-00-panel-discussion-sbrt-srs-case-studies-lung
#11
Stanley Benedict
: In this interactive session, lung SBRT patient cases will be presented to highlight real-world considerations for ensuring safe and accurate treatment delivery. An expert panel of speakers will discuss challenges specific to lung SBRT including patient selection, patient immobilization techniques, 4D CT simulation and respiratory motion management, target delineation for treatment planning, online treatment alignment, and established prescription regimens and OAR dose limits. Practical examples of cases, including the patient flow thought the clinical process are presented and audience participation will be encouraged...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048768/su-f-i-03-correction-of-intra-fractional-set-up-errors-and-target-coverage-based-on-cone-beam-computed-tomography-for-cervical-cancer-patients
#12
J Y Zhang, D L Hong
PURPOSE: The purpose of this study is to investigate the patient set-up error and interfraction target coverage in cervical cancer using image-guided adaptive radiotherapy (IGART) with cone-beam computed tomography (CBCT). METHODS: Twenty cervical cancer patients undergoing intensity modulated radiotherapy (IMRT) were randomly selected. All patients were matched to the isocenter using laser with the skin markers. Three dimensional CBCT projections were acquired by the Varian Truebeam treatment system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048757/mo-e-brb-01-panel-member
#13
S Benedict
: In this interactive session, lung SBRT patient cases will be presented to highlight real-world considerations for ensuring safe and accurate treatment delivery. An expert panel of speakers will discuss challenges specific to lung SBRT including patient selection, patient immobilization techniques, 4D CT simulation and respiratory motion management, target delineation for treatment planning, online treatment alignment, and established prescription regimens and OAR dose limits. Practical examples of cases, including the patient flow thought the clinical process are presented and audience participation will be encouraged...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048524/su-f-t-356-dosimetriccomparison-of-vmat-vs-step-and-shoot-imrt-plans-for-stage-iii-lung-cancerpatients-with-mediastinal-involvement
#14
D Pearson, J Bogue
PURPOSE: For Stage III lung cancers that entail treatment of some or all of the mediastinum, anterior-posterior focused Step and Shoot IMRT (SS-IMRT) and VMAT plans have been clinically used to deliver the prescribed dose while working to minimize lung dose and avoid other critical structures. A comparison between the two planning methods was completed to see which treatment method is superior and minimizes dose to healthy lung tissue. METHODS: Ten patients who were recently treated with SS-IMRT or VMAT plans for Stage III lung cancer with mediastinal involvement were selected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048520/we-a-brc-03-lessons-learned-iroc-audits
#15
D Followill
: Quality and safety in healthcare are inextricably linked. There are compelling data that link poor quality radiation therapy to inferior patient survival. Radiation Oncology clinical trial protocol deviations often involve incorrect target volume delineation or dosing, akin to radiotherapy incidents which also often involve partial geometric miss or improper radiation dosing. When patients with radiation protocol variations are compared to those without significant protocol variations, clinical outcome is negatively impacted...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048331/su-f-j-110-mri-guided-single-session-simulation-online-adaptation-and-treatment
#16
P Hill, M Geurts, K Mittauer, J Bayouth
PURPOSE: To develop a combined simulation and treatment workflow for MRI-guided radiation therapy using the ViewRay treatment planning and delivery system. METHODS: Several features of the ViewRay MRIdian planning and treatment workflows are used to simulate and treat patients that require emergent radiotherapy. A simple "pre-plan" is created on diagnostic imaging retrieved from radiology PACS, where conformal fields are created to target a volume defined by a physician based on review of the diagnostic images and chart notes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048245/su-f-j-157-effect-of-contouring-uncertainty-in-post-implant-dosimetry-of-low-dose-rate-prostate-permanent-seed-brachytherapy
#17
S Mashouf, H Safigholi, T Merino, A Soliman, A Ravi, G Morton, W Song
PURPOSE: There is strong evidence relating post-implant dosimetry for low-dose-rate (LDR) prostate seed brachytherapy to local control rates. The delineation of the prostate on CT images, however, represents a challenge due to the lack of soft tissue contrast in order to identify the prostate borders. This study aims at quantifying the sensitivity of clinically relevant dosimetric parameters to uncertainty in the contouring of prostate. METHODS: CT images, post-op plans and contours of a cohort of patients (n=43) (low risk=55...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048184/su-f-j-95-impact-of-shape-complexity-on-the-accuracy-of-gradient-based-pet-volume-delineation
#18
M Dance, G Wu, Y Gao, S Pirozzi, A Nelson, S Das, J Lian
PURPOSE: Explore correlation of tumor complexity shape with PET target volume accuracy when delineated with gradient-based segmentation tool. METHODS: A total of 24 clinically realistic digital PET Monte Carlo (MC) phantoms of NSCLC were used in the study. The phantom simulated 29 thoracic lesions (lung primary and mediastinal lymph nodes) of varying size, shape, location, and (18) F-FDG activity. A program was developed to calculate a curvature vector along the outline and the standard deviation of this vector was used as a metric to quantify a shape's "complexity score"...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048157/mo-d-brc-02-auto-planning
#19
P Xia
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048133/su-f-j-113-multi-atlas-based-automatic-organ-segmentation-for-lung-radiotherapy-planning
#20
J Kim, J Han, S Ailawadi, J Baker, A Hsia, Z Xu, S Ryu
PURPOSE: Normal organ segmentation is one time-consuming and labor-intensive step for lung radiotherapy treatment planning. The aim of this study is to evaluate the performance of a multi-atlas based segmentation approach for automatic organs at risk (OAR) delineation. METHODS: Fifteen Lung stereotactic body radiation therapy patients were randomly selected. Planning CT images and OAR contours of the heart - HT, aorta - AO, vena cava - VC, pulmonary trunk - PT, and esophagus - ES were exported and used as reference and atlas sets...
June 2016: Medical Physics
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