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Target volume delineation

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https://www.readbyqxmd.com/read/29681500/moving-toward-uniform-and-evidence-based-practice-of-radiotherapy-for-management-of-cervical-cancer-in-ontario-canada
#1
Negin Shahid, Timothy Craig, Mary Westerland, Allison Ashworth, Michelle Ang, David D'Souza, Raxa Sankreacha, Anthony Fyles, Michael Milosevic, Iwa Kong
PURPOSE: To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province. METHODS AND MATERIALS: An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care Ontario Gynecology Community of Practice (CoP) in 2013. The survey included 72 questions in four different categories: general/demographic, pretreatment assessment, external beam radiotherapy (EBRT), and brachytherapy (BT)...
April 19, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29676691/defining-the-lateral-limits-of-the-endoscopic-endonasal-transtuberculum-transplanum-approach-anatomical-study-with-pertinent-quantitative-analysis
#2
Alberto Di Somma, Jorge Torales, Luigi Maria Cavallo, Jose Pineda, Domenico Solari, Rosa Maria Gerardi, Federico Frio, Joaquim Enseñat, Alberto Prats-Galino, Paolo Cappabianca
OBJECTIVE The extended endoscopic endonasal transtuberculum transplanum approach is currently used for the surgical treatment of selected midline anterior skull base lesions. Nevertheless, the possibility of accessing the lateral aspects of the planum sphenoidale could represent a limitation for such an approach. To the authors' knowledge, a clear definition of the eventual anatomical boundaries has not been delineated. Hence, the present study aimed to detail and quantify the maximum amount of bone removal over the planum sphenoidale required via the endonasal pathway to achieve the most lateral extension of such a corridor and to evaluate the relative surgical freedom...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#3
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29652178/multi-modal-imaging-for-dose-planning-and-its-benefits-the-paradigm-of-head-and-neck-tumours
#4
V Grégoire
The ultimate goal of any radiotherapy is to eradicate the disease without inflicting damage on the normal tissues surrounding the tumours, which could be responsible for late treatment morbidity. To achieve this objective, the first step is to precisely select and delineate the target volumes to which a given dose will be prescribed. This step requires the use of multi-modal images from clinical examination to anatomical and molecular images. Imaging examination will be used not only to delineate the boundaries of the tumour volume, but also to assess tumour heterogeneity and, possibly, to guide a heterogeneous dose prescription (i...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29628205/dose-constraints-for-moderate-hypofractionated-radiotherapy-for-prostate-cancer-the-french-genito-urinary-group-getug-recommendations
#5
J Langrand-Escure, R de Crevoisier, C Llagostera, G Créhange, G Delaroche, C Lafond, C Bonin, F Bideault, P Sargos, S Belhomme, D Pasquier, I Latorzeff, S Supiot, C Hennequin
Considering recent phase III trials results, moderate hypofractionated radiotherapy can be considered as a standard treatment for low and intermediate risk prostate cancer management. This assessment call for a framework allowing homogeneous and reproducible practices in the different centers using this radiotherapy schedule. The French Genito-Urinary Group (GETUG) provides here recommendations for daily practice of moderate hypofractionated radiotherapy for prostate cancer, with indications, dose, fractionation, pre-treatment planning, volume of interest delineation (target volume and organs at risk) and margins, dose constraints and radiotherapy techniques...
April 5, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29628204/-evaluation-of-an-automatic-delineation-system-for-organs-at-risk-and-target-lymph-nodes-volumes-for-patients-treated-for-breast-cancer
#6
A Arsène-Henry, H-P Xu, M Robilliard, W El Amine, É Costa, Y M Kirova
PURPOSE: Intensity-modulated radiotherapy needs the strict delineation of target volumes as well as organs at risk and the time used for this procedure is long. The purpose of this study was to evaluate the Workflow Box system (Mirada Medical, UK) for automatic delineation and segmentation for everyday use of organs at risk and lymph nodes delineation in patients treated for early stage breast cancer. MATERIAL AND METHODS: Twenty patients' CT scans in treatment position for their breast cancer radiotherapy were delineated in respect of the ESTRO delineation guidelines to begin the creation of automatic delineation atlas...
April 5, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29623584/dosimetry-study-of-18-f-fmiso-pet-ct-hypoxia-imaging-guidance-on-intensity-modulated-radiation-therapy-for-non-small-cell-lung-cancer
#7
H Li, D Xu, X Han, Q Ruan, X Zhang, Y Mi, M Dong, S Guo, Y Lin, B Wang, G Li
OBJECTIVES: This study was to evaluate the feasibility of simultaneous integrated boost on tumor hypoxia area by studying the dosimetric change of hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer (NSCLC). METHODS: Five NSCLC patients with large hypoxic volume participated in this study. FDG PET/CT images were fused with CT localization images to delineate gross tumor volume. FMISO PET/CT images were fused with CT localization images to delineate hypoxic biological target volume (BTV) (tissue maximum ratio ≥ 1...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29621873/set-up-errors-in-head-and-neck-cancer-treated-with-imrt-technique-assessed-by-cone-beam-computed-tomography-a-feasible-protocol
#8
Durim Delishaj, Stefano Ursino, Francesco Pasqualetti, Fabrizio Matteucci, Agostino Cristaudo, Carlo Pietro Soatti, Amelia Barcellini, Fabiola Paiar
PURPOSE: To investigate set-up errors, suggest the adequate planning target volume (PTV) margin and image-guided radiotherapy frequency in head and neck (H&N) cancer treated with intensity-modulated radiotherapy (IMRT) assessed by kV cone-beam computed tomography (CBCT). METHODS: We analyzed 360 CBCTs in 60 patients with H&N cancer treated with IMRT. The target delineation was contoured according to ICRU62. PTVs were generated by adding a 3-5 mm margin in all directions to the respective clinical target volumes...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29609631/quantitative-analysis-of-respiration-induced-motion-of-each-liver-segment-with-helical-computed-tomography-and-4-dimensional-computed-tomography
#9
Yu-Lun Tsai, Ching-Jung Wu, Suzun Shaw, Pei-Chieh Yu, Hsin-Hua Nien, Louis Tak Lui
BACKGROUND: To analyze the respiratory-induced motion of each liver segment using helical computed tomography (helical CT) and 4-dimensional computed tomography (4DCT), and to establish the individual segment expansion margin of internal target volume (ITV) to facilitate target delineation of tumors in different liver segments. METHODS: Twenty patients who received radiotherapy with CT-simulation scanning of the whole liver in both helical CT and 10-phase-gated 4DCT were investigated, including 2 patients with esophagus cancer, 4 with lung cancer, 10 with breast cancer, 2 with liver cancer, 1 with thymoma, and 1 with gastric diffuse large B-cell lymphoma (DLBCL)...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29605476/estro-acrop-guidelines-for-target-volume-definition-in-the-treatment-of-locally-advanced-non-small-cell-lung-cancer
#10
Ursula Nestle, Dirk De Ruysscher, Umberto Ricardi, Xavier Geets, Jose Belderbos, Christoph Pöttgen, Rafal Dziadiuszko, Stephanie Peeters, Yolande Lievens, Coen Hurkmans, Ben Slotman, Sara Ramella, Corinne Faivre-Finn, Fiona McDonald, Farkhad Manapov, Paul Martin Putora, Cécile LePéchoux, Paul Van Houtte
Radiotherapy (RT) plays a major role in the curative treatment of locally advanced non-small cell lung cancer (NSCLC). Therefore, the ACROP committee was asked by the ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)radiotherapy (RT) and adjuvant RT for locally advanced NSCLC. The guidelines given here are a result of the evaluation of a structured questionnaire followed by a consensus discussion, voting and writing procedure within the committee...
March 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29603277/caliper-a-deformable-image-registration-algorithm-for-large-geometric-changes-during-radiotherapy-for-locally-advanced-non-small-cell-lung-cancer
#11
Christopher L Guy, Elisabeth Weiss, Gary E Christensen, Nuzhat Jan, Geoffrey D Hugo
PURPOSE: Locally-advanced non-small cell lung cancer (NSCLC) patients may experience dramatic changes in anatomy during radiotherapy and could benefit from adaptive radiotherapy (ART). Deformable image registration (DIR) is necessary to accurately accumulate dose during plan adaptation, but current algorithms perform poorly in the presence of large geometric changes, namely atelectasis resolution. The goal of this work is to develop a DIR framework, named Consistent Anatomy in Lung Parametric imagE Registration (CALIPER), to handle large geometric changes in the thorax...
March 30, 2018: Medical Physics
https://www.readbyqxmd.com/read/29598947/locoregional-extension-and-patterns-of-failure-for-nasopharyngeal-carcinoma-with-intracranial-extension
#12
Caineng Cao, Feng Jiang, Qifeng Jin, Ting Jin, Shuang Huang, Qiaoying Hu, Yuanyuan Chen, Yongfeng Piao, Yonghong Hua, Xinglai Feng, Xiaozhong Chen
OBJECTIVE: To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation. PATIENTS AND METHODS: A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed. RESULTS: According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10-35%), and low risk (<10%)...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594233/uptake-of-prostate-specific-membrane-antigen-psma-in-adenoid-cystic-carcinoma-is-psma-pet-ct-a-helpful-tool-in-radiation-oncology
#13
Laila König, Henrik Hauswald, Christa Flechtenmacher, Martina Heller, Jürgen Debus, Uwe Haberkorn, Clemens Kratochwil, Frederik Giesel
This case report shows the high PSMA-uptake in a patient with an adenoid cystic carcinoma of the maxillary sinus. Due to the intense ligand-uptake additional information for target volume delineation was obtained and the Treatment plan for bimodal radiotherapy with carbon ions was adapted accordingly.
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29580032/comparative-evaluation-of-a-6mv-flattened-beam-and-a-flattening-filter-free-beam-for-carcinoma-of-cervix-%C3%A2-imrt-planning-study
#14
Suresh Tamilarasu, Madeswaran Saminathan, S K Sharma, Anjali Pahuja, Abhinav Dewan
Purpose: Intensity modulated radiotherapy (IMRT) plan quality, beam on time and integral dose were compared using 6MV FB (Flattened Beam) and FFFB (Flattening filter free beam) for carcinoma of cervix. Materials and Methods: Ten patients with stage II–IIIB cervix cancer (Ca.Cx) were retrospectively identified from the department database. Target volume (TV) and organ at risk (OAR) were delineated as per Radiation Therapy Oncology Group (RTOG) cancer guidelines. Dose prescribed to planning target volume (PTV) was 50...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29578185/hypofractionated-postoperative-irradiation-in-localized-renal-cell-cancer-a-case-report-and-pertinent-literature-review
#15
Xiang-Rong Zhao, Guang-Lian Shan, Yong Zhang, Yong-Hua Yu
For localized the incidence of renal cell carcinoma (RCC), nephrectomy is the standard treatment. As RCC is generally regarded as a radiation-resistant tumor, the value of postoperative adjuvant radiotherapy is controversial. However, with new advance in radiotherapy (i.e., three-dimensional conformal radiation therapy [3DCRT] and intensity-modulated radiation therapy [IMRT]), target volume delineation, intensity modulation in treatment planning, and treatment delivery are more accurate with fewer adverse effect...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573194/long-term-outcomes-in-patients-with-nasopharyngeal-carcinoma-treated-with-reduced-volume-conformal-radiotherapy-a-retrospective-cohort-study
#16
Salem Billan, Veronique Bakouche, Egor Borzov, Ziv Gil, Roxolyana Abdah-Bortnyak
INTRODUCTION: While the optimal target volumes for primary nasopharyngeal tumour are still subject to debate, we evaluated primary tumour volumes in nasopharyngeal carcinoma (NPC) patients treated according to an institutional protocol with a reduced volume approach and compared them to those determined by Radiation Therapy Oncology Group (RTOG)-0615 guidelines. METHODS: This single-centre retrospective analysis included 36 NPC patients treated between 2/2007 and 3/2014...
March 23, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29559291/deep-learning-algorithm-for-auto-delineation-of-high-risk-oropharyngeal-clinical-target-volumes-with-built-in-dice-similarity-coefficient-parameter-optimization-function
#17
Carlos E Cardenas, Rachel E McCarroll, Laurence E Court, Baher A Elgohari, Hesham Elhalawani, Clifton D Fuller, Mona J Kamal, Mohamed A M Meheissen, Abdallah S R Mohamed, Arvind Rao, Bowman Williams, Andrew Wong, Jinzhong Yang, Michalis Aristophanous
PURPOSE: Automating and standardizing the contouring of clinical target volumes (CTVs) can reduce interphysician variability, which is one of the largest sources of uncertainty in head and neck radiation therapy. In addition to using uniform margin expansions to auto-delineate high-risk CTVs, very little work has been performed to provide patient- and disease-specific high-risk CTVs. The aim of the present study was to develop a deep neural network for the auto-delineation of high-risk CTVs...
February 7, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29556585/brachial-plexopathy-after-stereotactic-body-radiation-therapy-for-apical-lung-cancer-dosimetric-analysis-and-preliminary-clinical-outcomes
#18
Sumit S Sood, Christopher McClinton, Rajeev Badkul, Nathan Aguilera, Fen Wang, Allen M Chen
Purpose: The treatment of apical lung tumors with stereotactic body radiation therapy (SBRT) is challenging due to the proximity of the brachial plexus and the concern for nerve damage. Methods and materials: Between June 2009 and February 2017, a total of 75 consecutive patients underwent SBRT for T1-T3N0 non-small cell lung cancer involving the upper lobe of the lung. All patients were treated with 4-dimensional computed tomography (CT)-based image guided SBRT to a dose of 40 to 60 Gy in 3 to 5 fractions...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29545115/pre-and-postoperative-radiotherapy-for-extremity-soft-tissue-sarcoma-evaluation-of-inter-observer-target-volume-contouring-variability-among-french-sarcoma-group-radiation-oncologists
#19
P Sargos, T Charleux, R L Haas, A Michot, C Llacer, L Moureau-Zabotto, G Vogin, C Le Péchoux, C Verry, A Ducassou, M Delannes, A Mervoyer, N Wiazzane, J Thariat, M P Sunyach, M Benchalal, J D Laredo, M Kind, P Gillon, G Kantor
PURPOSE: The purpose of this study was to evaluate, during a national workshop, the inter-observer variability in target volume delineation for primary extremity soft tissue sarcoma radiation therapy. METHODS AND MATERIALS: Six expert sarcoma radiation oncologists (members of French Sarcoma Group) received two extremity soft tissue sarcoma radiation therapy cases 1: one preoperative and one postoperative. They were distributed with instructions for contouring gross tumour volume or reconstructed gross tumour volume, clinical target volume and to propose a planning target volume...
March 12, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29523410/an-atlas-to-aid-delineation-of-para-aortic-lymph-node-region-in-cervical-cancer-design-and-validation-of-contouring-guidelines
#20
Lorna G Keenan, Kathy Rock, Aini Azmi, Osama Salib, Charles Gillham, Orla McArdle
INTRODUCTION: Previous studies have investigated the anatomical distribution of para-aortic lymph nodes (PAN) in patients with cervical cancer. However, an atlas for accurate clinical target volume (CTV) delineation has yet to be defined. The purpose of this study was to design and verify a computerized tomography (CT) atlas to provide guidance for contouring the PAN CTV in patients with cervical cancer. MATERIALS AND METHODS: This prospective study included 21 cervical cancer patients (design cohort) with 39 pathological PAN identified on (18)F-FDG PET-CT...
March 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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