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Target volume delineation

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https://www.readbyqxmd.com/read/28725587/multi-parametric-mri-imaging-of-the-prostate-implications-for-focal-therapy
#1
REVIEW
James S Wysock, Herbert Lepor
The primary goal of a focal therapy treatment paradigm is to achieve cancer control through targeted tissue destruction while simultaneously limiting deleterious effects on peri-prostatic structures. Focal therapy approaches are employed in several oncologic treatment protocols, and have been shown to provide equivalent cancer control for malignancies such as breast cancer and renal cell carcinoma. Efforts to develop a focal therapy approach for prostate cancer have been challenged by several concepts including the multifocal nature of the disease and limited capability of prostate ultrasound and systematic biopsy to reliably localize the site(s) and aggressiveness of disease...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28713051/3d-visualization-and-pathological-characteristics-of-cartilage-and-subchondral-bone-changes-in-the-lumbar-facet-joint-of-an-ovariectomized-mouse-model
#2
Yong Cao, Shuangfei Ni, Tianding Wu, Chunyue Duan, Shenghui Liao, Jianzhong Hu
BACKGROUD CONTEXT: Low back pain (LBP) is more prevalent among postmenopausal women than men. Ovariectomy (OVX) is an established animal model that mimics the estrogen deficiency of postmenopausal women. Little is known about the morphological properties of cartilage and subchondral bone changes in the lumbar facet joint (LFJ) of an OVX mouse model. PURPOSE: The purpose of this study is to characterize the morphological change of cartilage and subchondral bone in LFJ of an OVX mouse model...
July 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28712277/moderate-hypofractionated-image-guided-thoracic-radiotherapy-for-locally-advanced-node-positive-non-small-cell-lung-cancer-patients-with-very-limited-lung-function-a-case-report
#3
Farkhad Manapov, Olarn Roengvoraphoj, Minglun Li, Chukwuka Eze
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28695316/interobserver-variability-in-target-volume-delineation-of-hepatocellular-carcinoma-an-analysis-of-the-working-group-stereotactic-radiotherapy-of-the-german-society-for-radiation-oncology-degro
#4
E Gkika, S Tanadini-Lang, S Kirste, P A Holzner, H P Neeff, H C Rischke, T Reese, F Lohaus, M N Duma, K Dieckmann, R Semrau, M Stockinger, D Imhoff, N Kremers, M F Häfner, N Andratschke, U Nestle, A L Grosu, M Guckenberger, T B Brunner
BACKGROUND: Definition of gross tumor volume (GTV) in hepatocellular carcinoma (HCC) requires dedicated imaging in multiple contrast medium phases. The aim of this study was to evaluate the interobserver agreement (IOA) in gross tumor delineation of HCC in a multicenter panel. METHODS: The analysis was performed within the "Stereotactic Radiotherapy" working group of the German Society for Radiation Oncology (DEGRO). The GTVs of three anonymized HCC cases were delineated by 16 physicians from nine centers using multiphasic CT scans...
July 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28673762/diffusion-weighted-mri-in-image-guided-adaptive-brachytherapy-tumor-delineation-feasibility-study-and-comparison-with-gec-estro-guidelines
#5
Antoine Schernberg, Corinne Balleyguier, Isabelle Dumas, Sébastien Gouy, Alexandre Escande, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To examine the feasibility of using diffusion-weighted images (DWIs) coregistered with T2-weighted (T2w) sequence in treatment planning system to improve target delineation for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer patients. METHODS AND MATERIALS: We retrospectively examined the records of consecutive patients who were referred to our institution for pulse-dose-rate IGABT between May and December 2015 after concurrent chemoradiation...
June 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28666905/triphasic-contrast-enhanced-ct-simulation-with-bolus-tracking-for-pancreas-sbrt-target-delineation
#6
Devon J Godfrey, Bhavik N Patel, Justus D Adamson, Ergys Subashi, Joseph K Salama, Manisha Palta
PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) delineation is unknown. This study evaluates the lesion conspicuity and consistency of pancreas stereotactic body radiation therapy (SBRT) GTVs contoured in the different contrast phases of triphasic CT simulation scans. METHODS AND MATERIALS: Triphasic, bolus-tracked planning CT simulation scans of 10 consecutive pancreas SBRT patients were acquired, yielding images of the pancreas during the late arterial (LA), portal venous (PV), and either the early arterial or delayed phase...
April 13, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28660217/a-prospective-study-comparing-functional-imaging-18-f-fdg-pet-versus-anatomical-imaging-contrast-enhanced-ct-in-dosimetric-planning-for-non-small-cell-lung-cancer
#7
Archana Prathipati, Ranadheer Gupta Manthri, Bala Venkat Subramanian, Pranabandhu Das, Swapna Jilla, Sangeetha Mani, Anitha Kumari J, Settipalli Sarala, Radhika Kottu, Tek Chand Kalawat, Kotiyala Venkata Jagannath Rao Naidu
OBJECTIVES: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET-CT) is a well-used and established technique for lung cancer staging. Radiation therapy requires accurate target volume delineation, which is difficult in most cases due to coexisting atelectasis. The present study was performed to compare the (18)F-FDG PET-CT with contrast enhanced computed tomography (CECT) in target volume delineation and investigate their impacts on radiotherapy planning...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28658110/the-clinical-outcome-correlations-between-radiation-dose-and-pretreatment-metabolic-tumor-volume-for-radiotherapy-in-head-and-neck-cancer-a-retrospective-analysis
#8
Shih-Neng Yang, Yu-Rou Chiou, Geoffrey G Zhang, Kuei-Ting Chou, Tzung-Chi Huang
This study was to investigate the clinical outcomes between radiation dose and pretreatment metabolic tumor volume (MTV) in patients with head and neck cancer treated with definitive chemoradiotherapy.Thirty-four patients received pretreatment F-fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT) were recruited for this study. The CT-based volume (gross tumor volume of the primary [GTVp]) and 4 types of MTVs were measured on the basis of either a maximal standardized uptake value (SUVmax) of 2...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28620579/delineation-of-the-prostate-bed-the-invisible-target-is-still-an-issue
#9
Igor Latorzeff, Paul Sargos, Geneviève Loos, Stéphane Supiot, Stéphane Guerif, Christian Carrie
For pathological high-risk prostate cancer, adjuvant irradiation has shown a survival benefit. Phase III studies have highlighted that half men would face biochemical relapse and would be candidate for radiotherapy at adjuvant or salvage times. Despite at least four published international contouring guidelines from different collaborative groups, discrepancies remain for volumes, delineation, and margins to be considered in order to optimize radiotherapy planning. This article from "Groupe d'Etude des Tumeurs UroGénitales (GETUG)" members will focus on controversies to help clinicians to create best volume delineation for adjuvant or salvage post prostatectomy radiotherapy...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28611300/consistency-mapping-of-16-lymph-node-stations-in-gastric-cancer-by-ct-based-vessel-guided-delineation-of-255-patients
#10
Shuhang Xu, Lingling Feng, Yongming Chen, Ying Sun, Yao Lu, Shaomin Huang, Yang Fu, Rongqin Zheng, Yujing Zhang, Rong Zhang
In order to refine the location and metastasis-risk density of 16 lymph node stations of gastric cancer for neoadjuvant radiotherapy, we retrospectively reviewed the initial images and pathological reports of 255 gastric cancer patients with lymphatic metastasis. Metastatic lymph nodes identified in the initial computed tomography images were investigated by two radiologists with gastrointestinal specialty. A circle with a diameter of 5 mm was used to identify the central position of each metastatic lymph node, defined as the LNc (the central position of the lymph node)...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608305/quality-assurance-of-the-preopanc-trial-2012-003181-40-for-preoperative-radiochemotherapy-in-pancreatic-cancer-the-dummy-run
#11
Eva Versteijne, Eelco Lens, Astrid van der Horst, Arjan Bel, Jorrit Visser, Cornelis J A Punt, Mustafa Suker, Casper H J van Eijck, Geertjan van Tienhoven
BACKGROUND: The Dutch Pancreatic Cancer Group initiated the national, multicentre, controlled PREOPANC trial, randomising between preoperative radiochemotherapy and direct explorative laparotomy for patients with (borderline) resectable pancreatic cancer. The aim of this dummy run is to evaluate compliance with the radiotherapy protocol of this trial, and the quality of delineation and radiation plans. METHODS: Eleven radiation oncology departments open for accrual of patients in the PREOPANC trial were provided with all necessary information of a selected 'dummy' patient...
June 12, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28602708/reduced-toxicity-with-equivalent-outcomes-using-three-dimensional-volumetric-3dv-image-based-versus-nonvolumetric-point-based-nv-brachytherapy-in-a-cervical-cancer-population
#12
Kimberly M Thomas, Genevieve Maquilan, Strahinja Stojadinovic, Paul Medin, Michael R Folkert, Kevin Albuquerque
PURPOSE: Brachytherapy (BT) techniques have historically used a two-dimensional nonvolumetric (NV) system involving dose prescribed to a point fixed in space. We compared dosimetric, toxicity, and oncologic outcomes for volumetric planning (3DV) versus CT point-based planning. METHODS AND MATERIALS: Patients treated with external beam radiation therapy and high dose rate (HDR) intracavitary BT were included (n = 71). Patients planned with NV BT treated from 2009 to 2011 (n = 37) were compared to patients planned with 3DV BT treated from 2012 to 2014 (n = 34)...
June 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28600139/change-of-target-volume-and-its-dosimetric-impact-during-the-course-of-accelerated-partial-breast-irradiation-using-intraoperative-multicatheter-interstitial-brachytherapy-after-open-cavity-surgery
#13
Ritu Raj Upreti, Ashwini Budrukkar, Udita Upreti, Shagun Misra, Tabassum Wadasadawala, Satish Kohle, Deepak D Deshpande
PURPOSE: To investigate the change of clinical target volume (CTV) and its dosimetric impact during the course of accelerated partial breast irradiation (APBI) using intraoperative multicatheter interstitial brachytherapy after open cavity surgery. METHODS AND MATERIALS: Twenty-two patients of APBI with intraoperative placement of catheters underwent computed tomography scans for the treatment planning before the first (CT1) and the last (CT2) treatment fraction...
June 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28600083/evaluation-of-clinical-target-volume-expansion-required-for-involved-site-neck-radiotherapy-for-lymphoma-to-account-for-the-absence-of-a-pre-chemotherapy-pet-ct-in-the-radiotherapy-treatment-position
#14
David Bird, Chirag Patel, Andrew F Scarsbrook, Viv Cosgrove, Emma Thomas, Di Gilson, Robin J D Prestwich
BACKGROUND AND PURPOSE: Involved site radiotherapy clinical target volume (CTV) for lymphoma requires an expansion to account for the absence of radiotherapy treatment-position pre-chemotherapy imaging, which is not widely implemented. This prospective imaging study aims to quantify CTV expansion required for neck radiotherapy. MATERIALS AND METHODS: 10 patients from a prospective single centre imaging study underwent a pre-chemotherapy FDG-PET-CT in both the diagnostic and radiotherapy treatment position, and subsequently received neck radiotherapy post-chemotherapy...
June 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28579419/the-effect-of-catheter-displacement-and-anatomical-variations-on-the-dose-distribution-in-mri-guided-focal-hdr-brachytherapy-for-prostate-cancer
#15
Metha Maenhout, Jochem R N van der Voort van Zyp, Maxence Borot de Battisti, Max Peters, Marco van Vulpen, Maurice van den Bosch, Marinus A Moerland
PURPOSE: The aim of this study was to analyze the effect of catheter displacement and anatomical variations of prostate and organs at risk on dose distribution in MRI-guided 19 Gy single fraction focal high-dose-rate brachytherapy (HDR-BT) of the prostate. METHODS AND MATERIALS: Seventeen patients with localized prostate cancer were enrolled in a prospective trial investigating focal HDR-BT in a 1.5 T MRI-HDR-BT facility. The diagnostic MRI delineations were registered with intraoperative MR scan, and a single fraction of 19 Gy was applied to the visible tumor...
June 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28573929/potential-for-interfraction-motion-to-increase-esophageal-toxicity-in-lung-sbrt
#16
Anthony Hoai-Nam Pham, Ellen Yorke, Andreas Rimner, Abraham Jing-Ching Wu
PURPOSE: To characterize the effect of the relative motion of esophagus and tumor on radiation doses to the esophagus in patients treated with stereotactic body radiation therapy for central lung tumors. METHODS AND MATERIALS: Fifty fractions of stereotactic body radiation therapy in 10 patients with lung tumors within 2.5 cm of the esophagus were reviewed. The esophagus was delineated on each treatment's cone-beam computed tomography scan and compared to its position on the planning scan...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28556781/supine-mri-for-regional-breast-radiotherapy-imaging-axillary-lymph-nodes-before-and-after-sentinel-node-biopsy
#17
Tristan C F van Heijst, Debora Eschbach-Zandbergen, Nienke Hoekstra, Bram van Asselen, Jan Lagendijk, Helena Verkooijen, Ruud Pijnappel, Stephanie de Waard, Arjen Witkamp, Thijs van Dalen, H J G van den Bongard, Marielle Philippens
Regional radiotherapy (RT) is increasingly used in breast-cancer treatment. Conventionally, computed tomography (CT) is performed for RT planning. Lymph node (LN) target levels are delineated according to anatomical boundaries. MRI could enable individual LN delineation. The purpose was to evaluate applicability of MRI for LN detection in supine treatment position, before and after sentinel-node biopsy (SNB). 23 female breast-cancer patients (cTis-3N0M0) underwent 1.5T MRI, before and after SNB, additional to CT...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28547592/impact-of-interim-progression-during-the-surgery-to-radiotherapy-interval-and-its-predictors-in-glioblastoma-treated-with-temozolomide-based-radiochemotherapy
#18
Chan Woo Wee, Eunji Kim, Tae Min Kim, Chul-Kee Park, Jin Wook Kim, Seung Hong Choi, Roh-Eul Yoo, Soon-Tae Lee, Il Han Kim
This study was designed to investigate the impact of interim progression of disease (PD) during the surgery-to-radiotherapy interval (SRI) and its predictors in glioblastoma based on MRIs. A total of 222 patients were planned for radiotherapy (RT) and 166 of them were evaluable for the presence of interim PD by 2 separate MRIs. The size criteria from the updated Response Assessment in Neuro-Oncology criteria was adopted to determine interim PD. 32 (19.3%) patients experienced interim PD, and their median survival (MS) was shorter than patients without PD in univariate (11...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28545588/patterns-of-local-regional-recurrence-after-conformal-and-intensity-modulated-radiotherapy-for-head-and-neck-cancer
#19
Safora Johansen, Mathilde H Norman, Einar Dale, Cecilie D Amdal, Torbjørn Furre, Eirik Malinen, Jan F Evensen
AIM: To evaluate the patterns of loco-regional recurrences in head and neck cancer patients METHODS: Twenty-six out of 112 patients treated with primary or postoperative 3D CRT or IMRT for their primary and recurrent disease between 2007 and 2013 were included. The CT images of recurrent disease were rigidly registered with the primary CT images for each patient. To assess overlaps and overlap localization, the recurrence volume overlapping with the primary target volume was identified...
May 25, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28543364/diffusion-weighted-mri-with-minimal-distortion-in-head-and-neck-radiotherapy-using-a-turbo-spin-echo-acquisition-method
#20
Tim Schakel, Johannes M Hoogduin, Chris H J Terhaard, Marielle E P Philippens
PURPOSE: Diffusion weighted (DW) MRI, showing high contrast between tumor and background tissue, is a promising technique in radiotherapy for tumor delineation. However, its use for head-and-neck patients is hampered by poor geometric accuracy in conventional echo planar imaging (EPI) DW-MRI. An alternative turbo spin echo sequence, DW-SPLICE, is implemented and demonstrated in patients. METHODS: The DW-SPLICE sequence was implemented on a 3.0T system and evaluated in 10 patients...
May 23, 2017: Medical Physics
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