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https://www.readbyqxmd.com/read/28237420/long-term-therapy-with-intrathecal-baclofen-improves-quality-of-life-in-children-with-severe-spastic-cerebral-palsy
#1
Tanja Kraus, Kathrin Gegenleitner, Martin Svehlik, Michael Novak, Gerhardt Steinwender, Georg Singer
INTRODUCTION: Children with severe spastic cerebral palsy (CP) are highly limited in daily life activities causing a reduced quality of life (QoL). This is partly due to an increased muscle tone causing pain and contractures. Continuous intrathecal infusion of baclofen (ITB) reduces the spasticity of affected patients. The hypothesis of the present study was that ITB leads to a significant improvement of QoL in non-ambulant children with CP. PATIENTS AND METHODS: 13 patients (10 male, 3 female, mean age 14 years) were included...
February 11, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28237315/loss-of-spatacsin-function-alters-lysosomal-lipid-clearance-leading-to-upper-and-lower-motor-neuron-degeneration
#2
Julien Branchu, Maxime Boutry, Laura Sourd, Marine Depp, Céline Leone, Alexandrine Corriger, Maeva Vallucci, Typhaine Esteves, Raphaël Matusiak, Magali Dumont, Marie-Paule Muriel, Filippo M Santorelli, Alexis Brice, Khalid Hamid El Hachimi, Giovanni Stevanin, Frédéric Darios
Mutations in SPG11 account for the most common form of autosomal recessive hereditary spastic paraplegia (HSP), characterized by a gait disorder associated with various brain alterations. Mutations in the same gene are also responsible for rare forms of Charcot-Marie-Tooth (CMT) disease and progressive juvenile-onset amyotrophic lateral sclerosis (ALS). To elucidate the physiopathological mechanisms underlying these human pathologies, we disrupted the Spg11 gene in mice by inserting stop codons in exon 32, mimicking the most frequent mutations found in patients...
February 22, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28236096/-cannabis-induced-disorders
#3
M Soyka, U Preuss, E Hoch
Use and misuse of cannabis and marihuana are frequent. About 5% of the adult population are current users but only 1.2% are dependent. The medical use of cannabis is controversial but there is some evidence for improvement of chronic pain and spasticity. The somatic toxicity of cannabis is well proven but limited and psychiatric disorders induced by cannabis are of more relevance, e.g. cognitive disorders, amotivational syndrome, psychoses and delusional disorders as well as physical and psychological dependence...
February 24, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28236062/bone-mineral-density-and-insulin-like-growth-factor-1-in-children-with-spastic-cerebral-palsy
#4
H Nazif, R Shatla, R Elsayed, E Tawfik, N Osman, S Korra, A Ibrahim
BACKGROUND: Children with cerebral palsy (CP) have significant decrease linear growth rate and low bone mineral density (BMD). AIMS: This study is to evaluate BMD in children with CP and its relation to the levels of insulin-like growth factor-1 (IGF-1). SUBJECTS AND METHODS: This cross-sectional study was carried out on 58 children suffering from spastic CP with the age range 4-12 years compared to 19 controls. All assessed by dual energy x-ray absorptiometry (DXA) to measure BMD, serum level of IGF-1, and serum vitamin D...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28235424/comparative-analysis-of-curative-effect-of-bone-marrow-mesenchymal-stem-cell-and-bone-marrow-mononuclear-cell-transplantation-for-spastic-cerebral-palsy
#5
Xuebin Liu, Xiaojun Fu, Guanghui Dai, Xiaodong Wang, Zan Zhang, Hongbin Cheng, Pei Zheng, Yihua An
BACKGROUND: Bone marrow mesenchymal stem cells (BMMSCs) and bone marrow mononuclear cells (BMMNCs) are both used to treat spastic cerebral palsy. However, the differences in therapeutic effect remain unknown. METHODS: A total of 105 patients with spastic cerebral palsy were enrolled and randomly assigned to three groups: the BMMSC group, the BMMNC group and the control group. Patients in both transplantation groups received four intrathecal cell injections. Patients in the control group received Bobath therapy...
February 24, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28231063/bone-age-in-unilateral-spastic-cerebral-palsy-is-there-a-correlation-with-hand-function-and-limb-length
#6
Je-Sang Lee, Im Jeong Choi, Myung Jun Shin, Jin-A Yoon, Sung Hwa Ko, Yong Beom Shin
BACKGROUND: The purpose of this study was to analyze the bone age and the upper extremity segmental lengths between the affected and the unaffected side and to reveal the correlation between the difference of bone age and the upper limb length discrepancy in the unilateral spastic cerebral palsy (CP). We also evaluated the relationship between difference of bone age and hand function. METHODS: Seventy-eight patients participated in this study. The bone ages of hand-wrists of the patients were determined by the Greulich and Pyle atlas...
February 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28230569/procedure-oriented-torsional-anatomy-of-the-hand-for-spasticity-injection
#7
Joslyn John, John Cianca, Faye Chiou-Tan, Sindhu Pandit, Erin Furr-Stimming, Katherine H Taber
OBJECTIVES: To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. After a stroke, spasticity can result in anatomic distortion of the hand. Spasticity may require treatment with botulinum toxin or phenol injections. Anatomic distortion may decrease the accuracy of injections. Standard anatomic references are of limited utility because they are not in this spastic hemiparetic position. There presently is no anatomic reference in the literature for these spastic postures...
February 23, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28227902/impairment-of-muscle-force-transmission-in-spastic-paretic-muscles-of-stroke-survivors
#8
Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh, Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh, Xiaogang Hu, Babak Afsharipour, William Zev Rymer, Nina L Suresh
Hemispheric stroke survivors tend to have persistent motor impairments, with muscle weakness and muscle spasticity observed concurrently in the affected muscles. The objective of this preliminary study was to identify whether impairment of muscle force transmission could contribute to weakness in spastic-paretic muscles of chronic stroke survivors. To characterize the efficiency of the transmission of muscle forces to the tendon, we activated biceps brachii muscle electrically by stimulating the musculocutaneous nerve with maximum current...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227562/improving-modified-tardieu-scale-assessment-using-inertial-measurement-unit-with-visual-biofeedback
#9
Seoyoung Choi, Jonghyun Kim, Seoyoung Choi, Jonghyun Kim, Seoyoung Choi, Jonghyun Kim
Reliable spasticity assessment is important to provide appropriate intervention for spasticity. Modified Tardieu scale (MTS) assessment is simple and convenient enough to be used in clinical environment, but has poor or moderate reliability due to irregular passive stretch velocity and goniometric measurement. We proposed a novel inertial measurement unit (IMU)-based MTS assessment with gyroscope-based visual biofeedback to improve the reliability of MTS by providing regular passive stretch velocity. With five children with cerebral palsy and two raters, the IMU-based MTS assessment was compared with conventional MTS assessment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227340/mechanomyography-signals-in-spastic-muscle-and-the-correlation-with-the-modified-ashworth-scale
#10
E L Santos, M C Santos, E Krueger, G N Nogueira-Neto, P Nohama, E L Santos, M C Santos, E Krueger, G N Nogueira-Neto, P Nohama, G N Nogueira-Neto, M C Santos, E Krueger, E L Santos, P Nohama
The modified Ashworth scale (MAS) is the most widely used measurement technique to assess levels of spasticity. In MAS, the evaluator graduates spasticity considering his/her subjective analysis of the muscular endurance during passive stretching. Therefore, it is a subjective scale. Mechanomyography (MMG) allows registering the vibrations generated by muscle contraction and stretching events that propagate through the tissue until the surface of the skin. With this in mind, this study aimed to investigate possible correlations between MMG signal and muscle spasticity levels determined by MAS...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227301/an-adapted-double-threshold-protocol-for-spastic-muscles
#11
Pedro M Vieira, Joao F Ferreira, Pedro R Gomes, Carlos S Lima, Pedro M Vieira, Joao F Ferreira, Pedro R Gomes, Carlos S Lima, Pedro M Vieira, Joao F Ferreira, Pedro R Gomes, Carlos S Lima
The onset of muscle contraction has been an important element in the understanding of human motor control system as well as in the development of medical devices. This task is problematic in the study of spasticity using surface Electromyography (sEMG). In fact, spasticity is characterized by involuntary muscle contractions that can be seen as both, a non-stationary background if they are weak or a severe non-stationary EMG signal if they are strong. In other hand, these sEMG signals present a very low signal to noise ratio, beyond the added noise that contaminates this signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226846/quantification-of-a-single-score-1-in-the-modified-ashworth-scale-mas-a-clinical-assessment-of-spasticity
#12
Jourdan K Ewoldt, Emily C Lazzaro, Elliot J Roth, Nina L Suresh, Jourdan K Ewoldt, Emily C Lazzaro, Elliot J Roth, Nina L Suresh, Emily C Lazzaro, Elliot J Roth, Jourdan K Ewoldt, Nina L Suresh
The Modified Ashworth Scale (MAS) is an assessment that is often used by clinicians to grade spasticity in the affected limbs of stroke survivors. The MAS is a function of the angle at which the clinician perceives a resistance to stretch and/or a `catch' during a passive joint rotation. The qualitative nature of the assessment in combination with the low resolution of the scale could result in varied grouping of spastic patients, even for a single score. The objective of this pilot study was to develop a method for the quantification of the MAS, which could provide greater resolution and could eventually guide better informed therapeutic interventions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226844/estimation-of-gait-parameter-using-sonoelastography-in-children-with-cerebral-palsy
#13
M Mansouri, P M Birgani, M R Kharazi, M Lotfian, M Naeimipoor, M M Mirbagheri, M Mansouri, P M Birgani, M R Kharazi, M Lotfian, M Naeimipoor, M M Mirbagheri, M Naeimipoor, M Lotfian, M M Mirbagheri, M Mansouri, P M Birgani, M R Kharazi
We aimed to study the relationship between neuromuscular abnormalities associated with spasticity and gait impairments in spastic children with hemiplegia cerebral palsy (CP). Neuromuscular abnormalities of the tibialis anterior and medial gastrocnemius muscles of the spastic ankle were quantified using sonoelastography with two major features; i.e. entropy and histogram ratio of sonoelastography images. Gait impairments were evaluated in the gait laboratory using motion capture system, and the spatial and temporal features were extracted...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226839/pendulum-test-measure-correlates-with-gait-parameters-in-children-with-cerebral-palsy
#14
M Lotfian, M M Mirbagheri, M R Kharazi, F Dadashi, R Nourian, A Irani, A Mirbagheri, M Lotfian, M M Mirbagheri, M R Kharazi, F Dadashi, R Nourian, A Irani, A Mirbagheri, M Lotfian, R Nourian, M M Mirbagheri, A Mirbagheri, A Irani, F Dadashi, M R Kharazi
Individuals with cerebral palsy (CP) usually suffer from different impairments including gait impairment and spasticity. Spastic hypertonia is a defining feature of spasticity and manifests as a mechanical abnormality. The objective of this study was to determine the relationship between spastic hypertonia and gait impairments in spastic children with CP, addressing an important controversial issue. Spastic hypertonia was quantified using the pendulum test. The gait impairments were evaluated using the motion capture system in a gait laboratory...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226453/spatial-characterization-of-innervation-zones-under-electrically-elicited-m-wave
#15
C Zhang, Y Peng, S Li, P Zhou, A Munoz, D Tang, Y Zhang, C Zhang, Y Peng, S Li, P Zhou, A Munoz, D Tang, Y Zhang, C Zhang, P Zhou, D Tang, Y Zhang, S Li, A Munoz, Y Peng
The three dimensional (3D) innervation zone (IZ) imaging approach (3DIZI) has been developed in our group to localize the IZ of a particular motor unit (MU) from its motor unit action potentials decomposed from high-density surface electromyography (EMG) recordings. In this study, the developed 3DIZI approach was combined with electrical stimulation to investigate global distributions of IZs in muscles from electrically elicited M-wave recordings. Electrical stimulations were applied to the musculocutaneous nerve to activate supramaximal muscle response of the biceps brachii in one healthy subject, and high-density (128 channels) surface EMG signals of the biceps brachii muscles were recorded...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225648/safety-of-autologous-human-schwann-cell-transplantation-in-subacute-thoracic-spinal-cord-injury
#16
Kimberly D Anderson, James Guest, W Dalton Dietrich, Mary B Bunge, Rosie Curiel, Marine Dididze, Barth A Green, Aisha Khan, Damien D Pearse, Efrat Saraf-Lavi, Eva Widerstrom-Noga, Pat Wood, Allan D Levi
The rationale for implantation of autologous human Schwann cells (SCs) in people with subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are neuroprotective, support local axonal plasticity, and are capable of myelinating axons. A Phase I clinical trial was conducted to evaluate the safety of autologous human SC transplantation into the injury epicenter of six subjects with subacute SCI. The trial was an open-label, unblinded, non-randomized, non-placebo controlled study with a dose escalation design and standard medical rehabilitation...
February 18, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28225536/reliability-and-cross-cultural-adaptation-of-the-turkish-version-of-the-spinal-cord-injury-spasticity-evaluation-tool
#17
Pinar Akpinar, Arzu Atici, Kubra N Kurt, Feyza U Ozkan, Ilknur Aktas, Duygu G Kulcu
The Spinal Cord Injury Spasticity Evaluation Tool is a 7-day recall self-reported questionnaire that assesses the problematic and useful effects of spasticity on daily life in patients with spinal cord injury (SCI). We aimed to determine the reliability and cross-cultural validation of the Turkish translation of the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SETT). After translation and back translation of the Spinal Cord Injury Spasticity Evaluation Tool, 66 patients between the ages of 18 and 88 years with SCI, American Spinal Injury Association impairment scale grades from A to D with spasticity, and at least 6 months after injury were assessed...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28225535/treatment-diary-for-botulinum-toxin-spasticity-treatment-a-pilot-study
#18
Bo Biering-Sørensen, Helle K Iversen, Inge M S Frederiksen, Jeanet R Vilhelmsen, Fin Biering-Sørensen
The aim of this study is to develop a treatment diary for patients receiving spasticity treatment including botulinum toxin injection and physiotherapy and/or occupational therapy. The diary focuses on problems triggered by skeletal muscle overactivity; agreed goals for treatment and the patient's self-evaluation of achievement on the Goal Attainment Scale; which skeletal muscles were injected; physiotherapists' and occupational therapists' evaluation of the patients' achievement of objectives on the Goal Attainment Scale; and proposals for optimization of treatment and changing goals...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28224608/inter-and-intrarater-clinician-agreement-on-joint-motion-patterns-during-gait-in-children-with-cerebral-palsy
#19
Angela Nieuwenhuys, Eirini Papageorgiou, Guy Molenaers, Davide Monari, Tinne de Laet, Kaat Desloovere
AIM: This study aimed to quantify the inter- and intrarater clinician agreement on joint motion patterns in children with spastic cerebral palsy (CP), which were recently specified by a Delphi consensus study. It also examined whether experience with three-dimensional gait analysis (3DGA) is a prerequisite for using the patterns. METHOD: The experimental group consisted of 82 patients with CP (57 males, 25 females; uni-/bilateral CP [n=27/55]; Gross Motor Function Classification System levels I to III; mean age 9y 5mo [range 4y-18y])...
February 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28222565/carbon-modular-orthosis-ca-m-o-an%C3%A2-innovative-hybrid-modular-ankle-foot-orthosis-to-tune-the-variable-rehabilitation-needs-in-hemiplegic-cerebral-palsy
#20
E Tavernese, M Petrarca, G Rosellini, E Di Stanislao, A Pisano, G Di Rosa, E Castelli
BACKGROUND: Hemiplegic Celebral Palsy (CP) children commonly use AFO orthoses as walking aids. It is known that AFOs may have a detrimental effect on gait. To enhance mechanical properties of AFOs we developed an innovative, custom-made, carbon, ankle-foot orthosis (Ca.M.O) which offers the opportunity to tune its response to the patient's gait characteristics and/or functional maturity. OBJECTIVE: To assess the efficacy of Ca.M.O. in improving gait in a group of hemiplegic CP children and to compare its performances with those of commonly prescribed AFO...
February 10, 2017: NeuroRehabilitation
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