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Iron absorption

Sintayehu Ambachew, Belete Biadgo
The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin...
November 15, 2017: Acta Haematologica
Robert Seidel, Katrin Kraffert, Anke Kabelitz, Marvin N Pohl, Ralph Kraehnert, Franziska Emmerling, Bernd Winter
The nature of the small iron-oxo oligomers in iron-(iii) aqueous solutions has a determining effect on the chemical processes that govern the formation of nanoparticles in aqueous phase. Here we report on a liquid-jet photoelectron-spectroscopy experiment for the investigation of the electronic structure of the occurring iron-oxo oligomers in FeCl3 aqueous solutions. The only iron species in the as-prepared 0.75 M solution are Fe(3+) monomers. Addition of NaOH initiates Fe(3+) hydrolysis which is followed by the formation of iron-oxo oligomers...
November 13, 2017: Physical Chemistry Chemical Physics: PCCP
Mohsen Lashgari, Majid Ghanimati
H2S is a corrosive, flammable and noxious gas, which can be neutralized by dissolving in alkaline media and employed as H2-source by utilizing inside semiconductor-assisted/photochemical reactors. Herein, through a facile hydrothermal route, a ternary nanostructured solid-solution of iron, zinc and sulfur was synthesized in the absence and presence of Ag-dopant, and applied as efficient photocatalyst of hydrogen fuel production from H2S media. The effect of pH on the photocatalyst performance was scrutinized and the maximum activity was attained at pH=11, where HS(-) concentration is high...
November 6, 2017: Journal of Hazardous Materials
Wenhong Gao, Yangping Huang, Ruixue He, Xin-An Zeng
A new ion exchange column method was investigated to synthesize the soluble soybean polysaccharide-iron(III) complex (SSPS-FeIII(1)) using soluble soybean polysaccharides (SSPS). The feasibility of ion exchange column reaction was explored firstly. Results indicated the D730 anion macroporous adsorption resin could effectively absorb SSPS and the static adsorption saturation time was 20h. The iron content of the complex reached up to 15.07% when trisodium citrate concentration was 2mg/mL. The structure of SSPS-FeIII complex synthesized by this method (SSPS-FeIII1(2)) was compared with that prepared by trisodium citrate - ferric chloride method (SSPS-FeIII2(3))...
November 8, 2017: International Journal of Biological Macromolecules
Jin Liu, Jianjun Yang, Barbara J Cade-Menun, Yongfeng Hu, Jumei Li, Chang Peng, Yibing Ma
Soil legacy phosphorus (P) represents a substantial secondary P resource to postpone the global P crisis. To fully utilize this P reserve, the transformation of legacy P speciation in a black soil with and without P fertilization for 27 years was investigated by chemical fractionation, molecular-level bulk (P K-edge X-ray absorption near-edge, XANES; solution (31)P nuclear magnetic resonance) and microprobe (µ-X-ray fluorescence and µ-XANES) spectroscopy. Results from both fractionation and P bulk-XANES concordantly indicated that Ca2-P [Ca(H2PO4)2] acts as a reserve of labile P in response to soils with or without P fertilization...
November 10, 2017: Scientific Reports
Katica Prskalo, Eva Klarić Sever, Ivan Alerić, Tatjana Antonić Jelić, Ivona Žaja
The aim of the study was to show whether there is any influence of food, drink or drug intake on the formation of tooth discoloration. A total of 500 patients aged 15-25 years were examined to take part in the study. Of these, 60 patients were selected and divided into two groups of 30 patients each. Group 1 included patients with black pigmentation on vestibular/oral tooth surfaces. Group 2 included patients without discoloration (control). Data were recorded in a questionnaire. Atomic absorption spectrometry was used to determine elements in discoloration samples...
March 2017: Acta Clinica Croatica
Nsikak U Benson, Winifred U Anake, Adebusayo E Adedapo, Omowunmi H Fred-Ahmadu, Olusegun O Ayejuyo
This study evaluated the concentrations of cadmium (Cd), copper (Cu), iron (Fe), manganese (Mn), lead (Pb), and zinc (Zn) in 10 branded cigarettes commonly consumed in Nigeria. Chemical sequential extraction method and pseudo-total metal digestion procedure were used for extraction of metals from filler tobacco and filter samples. Samples were analyzed using flame atomic absorption spectrometry (FAAS). The filler tobacco of cigarettes had Cd, Cu, Fe, Mn, Pb, and Zn concentrations in the ranges of 5.90-7.94, 18...
November 8, 2017: Environmental Monitoring and Assessment
J López-Sánchez, A Muñoz-Noval, C Castellano, A Serrano, A Del Campo, M Cabero, M Varela, M Abuín, J de la Figuera, J F Marco, G R Castro, O Rodríguez de la Fuente, N Carmona
The current study unveils the structural origin of the magnetic transition of the ε-Fe2O3 polymorph from an incommensurate magnetic order to a collinear ferrimagnetic state at low temperature. The high crystallinity of the samples and the absence of other iron oxide polymorphs have allowed us to carry out temperature-dependent x-ray absorption fine structure spectroscopy experiments out. The deformation of the structure is followed by the Debye-Waller factor for each selected Fe-O and Fe-Fe sub-shell. For nanoparticle sizes between 7 and 15 nm, the structural distortions between the Fete and Fe-D1oc sites are localized in a temperature range before the magnetic transition starts...
November 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Babamale O Abdulkareem, Abdulkareem O Adam, Akande O Ahmed, Afolayan A Mariam, Ugbomoiko U Samuel
Interaction between malaria, anaemia and malnutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Saharan Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorption spectrophotometer respectively...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Song Tan, Peng Zhang, Wei Xiao, Bing Feng, Lan-You Chen, Shuang Li, Peng Li, Wei-Zhong Zhao, Xiao-Ting Qi, Li-Ping Yin
Iron is essential for most living organisms. The iron-regulated transporter1 (IRT1) plays a major role in iron uptake in roots, and its trafficking from endoplasmic reticulum (ER) to plasma membrane (PM) is tightly coordinated with changes in iron environment. However, studies on IRT1 response are limited. Here, we report that Malus xiaojinesis IRT1 (MxIRT1) associates with detergent-resistant membranes (DRMs, a biochemical counterpart of PM microdomains), whereas the PM microdomains are known platforms for signal transduction in the PM...
November 7, 2017: Traffic
Yi-Huang Hsueh, Ping-Han Tsai, Kuen-Song Lin, Wan-Ju Ke, Chao-Lung Chiang
BACKGROUND: Zero-valent iron nanoparticles (ZVI NPs) have been used extensively for the remediation of contaminated soil and groundwater. Owing to their large active surface area, they serve as strong and effective reductants. However, the ecotoxicity and bioavailability of ZVI NPs in diverse ecological media have not been evaluated in detail and most studies have focused on non-nano ZVI or Fe(0). In addition, the antimicrobial properties of ZVI NPs have rarely been investigated, and the underlying mechanism of their toxicity remains unknown...
November 3, 2017: Journal of Nanobiotechnology
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
November 2, 2017: Pharmacogenetics and Genomics
Gautam Rishi, V Nathan Subramaniam
Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone-hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis...
November 2, 2017: Bioscience Reports
Xiuting Chen, Qingnuan Li, Lester Andrews, Yu Gong
Mono and diisocyanide complexes of manganese and iron were prepared via the reactions of laser-ablated manganese and iron atoms with (CN)2 in an argon matrix. Product identifications were performed based on the characteristic infrared absorptions from isotopically labeled (CN)2 experiments as compared with computed values for both cyanides and isocyanides. Manganese atoms reacted with (CN)2 to produce Mn(NC)2 upon λ > 220 nm irradiation, during which MnNC was formed mainly as a result of the photoinduced decomposition of Mn(NC)2...
November 14, 2017: Journal of Physical Chemistry. A
Marianne S Morseth, Liv Elin Torheim, Ram K Chandyo, Manjeswori Ulak, Sanjaya K Shrestha, Binob Shrestha, Are Hugo Pripp, Sigrun Henjum
Prevalence of micronutrient deficiencies is high among infants and children in low- and middle income countries, but knowledge about nutrient adequacy across the complementary feeding period is limited. We investigated probability of adequacy (PA) of breast milk and complementary food combined and nutrient density adequacy (NDA) of complementary food and tracking of NDA over time among 229 children from 9-24 months of age in Bhaktapur, Nepal. Monthly, 24 h dietary recalls (16 in total) were performed and subgrouped into four 4-month time periods...
November 2, 2017: Maternal & Child Nutrition
Sangsul Lee, Ik Hwan Kwon, Jae Young Kim, Sung Sun Yang, Sechang Kang, Jun Lim
For spectral imaging of chemical distributions using X-ray absorption near-edge structure (XANES) spectra, a modified double-crystal monochromator, a focusing plane mirrors system and a newly developed fluorescence-type X-ray beam-position monitoring and feedback system have been implemented. This major hardware upgrade provides a sufficiently stable X-ray source during energy scanning of more than hundreds of eV for acquisition of reliable XANES spectra in two-dimensional and three-dimensional images. In recent pilot studies discussed in this paper, heavy-metal uptake by plant roots in vivo and iron's phase distribution in the lithium-iron-phosphate cathode of a lithium-ion battery have been imaged...
November 1, 2017: Journal of Synchrotron Radiation
José María Moreno-Navarrete, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Javier Salvador, Gema Frühbeck, José Manuel Fernández-Real
SCOPE: To investigate intestinal markers of iron absorption in morbidly obese subjects according to glucose tolerance. METHODS AND RESULTS: Gene expression of both non-heme [SLC40A1 (ferroportin), SLC11A2] and heme iron [SLC46A1 (HCP1), HMOX1] transporters were analysed in 38 small intestine tissue samples [11 with normal glucose tolerance, 14 with glucose intolerance (GI) and 13 with newly diagnosed type 2 diabetes (T2D)]. SLC40A1 (r = 0.43, p = 0.008) and SLC11A2 (r = 0...
October 29, 2017: Molecular Nutrition & Food Research
Marzia Bellei, Carlo Augusto Bortolotti, Giulia Di Rocco, Marco Borsari, Lidia Lancellotti, Antonio Ranieri, Marco Sola, Gianantonio Battistuzzi
Neuroglobin is a monomeric globin containing a six-coordinate heme b, expressed in the nervous system, which exerts an important neuroprotective role. In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of the CD loop that strengthens the bond between the heme iron and the distal histidine. Hence, it is conceivable that the intramolecular disulfide bridge modulates the functionality of human neuroglobin by controlling exogenous ligand binding...
October 16, 2017: Journal of Inorganic Biochemistry
Xiangjun Chen, Guilan Li, Qinghe Han, Xiliang Li, Lu Li, Tingting Wang, Chungang Wang
We report a facile and simple hydrogen reduction method to fabricate PEGylated branched gold (Au)-iron oxide (Fe3O4) Janus nanoparticles (JNPs). Note that, the hydrogen induces the formation of Fe3O4 during the synthesis process. Due to the strong absorption in the near-infrared range, branched Au-Fe3O4 JNPs showed a significant photothermal effect with a 40% calculated photothermal transduction efficiency under a laser irradiation of 808 nm in vitro. Owing to their excellent optical and magnetic properties, branched Au-Fe3O4 JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/photoacoustic imaging (PAI)/computed tomography (CT) in vitro...
October 26, 2017: Chemistry: a European Journal
Samie Salehi, Amir Sh Saljooghi, Somayeh Badiee, Mojtaba Mashmool Moqadam
Thallium and its compounds are a class of highly toxic chemicals that cause wide-ranging symptoms such as gastrointestinal disturbances; polyneuritis; encephalopathy; tachycardia; skin eruptions; hepatic, renal, cardiac, and neurological toxicities; and have mutagenic and genotoxic effects. The present research aimed to evaluate the efficacy of the chelating agents deferasirox (DFX) and deferiprone (L1) in reducing serum and tissue thallium levels after the administration of thallium (III), according to two different dosing regimens, to several groups of Wistar rats for 60 days...
October 2017: Toxicological Research
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