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Iron absorption

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https://www.readbyqxmd.com/read/28937756/direct-comparison-of-c-h-bond-amination-efficacy-through-manipulation-of-nitrogen-valence-centered-redox-imido-versus-iminyl
#1
Matthew J T Wilding, Diana A Iovan, Alexandra T Wrobel, James T Lukens, Samantha N MacMillan, Kyle M Lancaster, Theodore A Betley
Reduction of previously reported iminyl radical (ArL)FeCl(•N(C6H4-p-tBu)) (2) with potassium graphite furnished the corresponding high-spin (S = 5/2) imido (ArL)Fe(N(C6H4-p-tBu)) (3) (ArL = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin). Oxidation of the three-coordinate imido (ArL)Fe(NAd) (5) with chlorotriphenylmethane afforded (ArL)FeCl(•NAd) (6) with concomitant expulsion of Ph3C(C6H5)CPh2. The respective alkyl/aryl imido/iminyl pairs (3, 2; 5, 6) have been characterized by EPR, zero-field 57Fe Mössbauer, magnetometry, single crystal X-ray diffraction, XAS, and EXAFS for 6...
September 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28937159/duodenal-cytochrome-b-cybrd1-ferric-reductase-functional-studies-in-cells
#2
F Schlottmann, M Vera-Aviles, G O Latunde-Dada
Dietary non-heme ferric iron is reduced by the ferric reductase enzyme, duodenal cytochrome b (Dcytb), before absorption by the divalent metal transporter 1 (DMT1). A single nucleotide polymorphism (SNP rs10455 mutant) that is located in the last exon of the Dcytb gene was reported in C282Y haemochromatosis HFE subjects. The present work therefore investigated the phenotype of this mutant Dcytb in Chinese hamster ovary (CHO) cells. These cultured cells were transfected with either wild type (WT) or the SNP vector plasmids of Dcytb...
September 22, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28933158/first-principles-fe-l2-3-edge-and-o-k-edge-xanes-and-xmcd-spectra-for-iron-oxides
#3
Michel Sassi, Carolyn I Pearce, Paul S Bagus, Elke Arenholz, Kevin M Rosso
X-ray absorption near edge structure (XANES) and X-ray magnetic circular dichroism (XMCD) spectroscopies are tools in widespread use for providing detailed local atomic structure, oxidation state, and magnetic structure information for materials and organometallic complexes. Analysis of these spectra for transition metal L-edges is routinely performed on the basis of ligand-field multiplet theory because one- and two-particle mean field ab initio methods typically cannot describe the multiplet structure. Here we show that multireference configuration interaction (MRCI) calculations can satisfactorily reproduce measured XANES spectra for a range of complex iron oxide materials including hematite and magnetite...
September 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28928510/co-extrusion-of-food-grains-banana-pulp-for-nutritious-snacks-optimization-of-process-variables
#4
D Mridula, Swati Sethi, Surya Tushir, Sheetal Bhadwal, R K Gupta, S K Nanda
Present study was undertaken to optimize the process conditions for development of food grains (maize, defatted soy flour, sesame seed)-banana based nutritious expanded snacks using extrusion processing. Experiments were designed using Box-Behnken design with banana pulp (8-24 g), screw speed (300-350 rpm) and feed moisture (14-16% w.b.). Seven responses viz. expansion ratio (ER), bulk density (BD), water absorption index (WAI), protein, minerals, iron and sensory acceptability were considered for optimizing independent parameters...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28924039/matriptase-2-suppresses-hepcidin-expression-by-cleaving-multiple-components-of-the-hepcidin-induction-pathway
#5
Mastura Wahedi, Aaron W Wortham, Mark D Kleven, Ningning Zhao, Shall Jue, Caroline A Enns, An-Sheng Zhang
Systemic iron homeostasis is maintained by regulation of iron absorption in the duodenum, iron recycling from erythrocytes, and iron mobilization from the liver and is controlled by the hepatic hormone hepcidin. Hepcidin expression is induced via the bone morphogenetic protein (BMP) signaling pathway that preferentially uses two type-I (ALK2 and ALK3) and two type-II (ActRIIA and Bmpr2) BMP receptors. Hemojuvelin (HJV), HFE, and transferrin receptor-2 (TfR2) facilitate this process presumably by forming a plasma membrane complex with BMP receptors...
September 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28921771/iron-deficiency-stress-can-induce-mxnas1-protein-expression-to-facilitate-iron-redistribution-in-malus-xiaojinensis
#6
Chaohua Sun, Mudan Yuan, Longmei Zhai, Duyue Li, Xinzhong Zhang, Ting Wu, Xuefeng Xu, Yi Wang, Zhenhai Han
Iron (Fe) is a vital trace element in plants and deficiency of this element in apple trees can reduce fruit quality. Nicotianamine (NA) is known to play an important role in Fe transport and endogenous hormone balance. In the present study, we investigated the role of a nicotianamine synthase 1 gene (MxNas1) in an apple species, Malus xiaojinensis, that has an Fe-efficient genotype than other apple species and ecotypes. To characterize the response of M. xiaojinensis to Fe-deficiency, we used quantitative Q-PCR to determine the level of expression of MxNas1 and western blot to measure protein levels...
September 16, 2017: Plant Biology
https://www.readbyqxmd.com/read/28919740/low-toxic-maghemite-nanoparticles-for-theranostic-applications
#7
Elena A Kuchma, Peter V Zolotukhin, Anna A Belanova, Mikhail A Soldatov, Tatiana A Lastovina, Stanislav P Kubrin, Anatoliy V Nikolsky, Lidia I Mirmikova, Alexander V Soldatov
BACKGROUND: Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine. METHODS: Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919500/hydrogen-and-oxygen-trapping-at-the-h-cluster-of-fefe-%C3%A2-hydrogenase-revealed-by-site-selective-spectroscopy-and-qm-mm-calculations
#8
Stefan Mebs, Ramona Kositzki, Jifu Duan, Moritz Senger, Florian Wittkamp, Ulf-Peter Apfel, Thomas Happe, Sven T Stripp, Martin Winkler, Michael Haumann
[FeFe]‑hydrogenases are superior hydrogen conversion catalysts. They bind a cofactor (H-cluster) comprising a four‑iron and a diiron unit with three carbon monoxide (CO) and two cyanide (CN(-)) ligands. Hydrogen (H2) and oxygen (O2) binding at the H-cluster was studied in the C169A variant of [FeFe]‑hydrogenase HYDA1, in comparison to the active oxidized (Hox) and CO-inhibited (Hox-CO) species in wildtype enzyme. (57)Fe labeling of the diiron site was achieved by in vitro maturation with a synthetic cofactor analogue...
September 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28919419/binding-mode-of-metal-ions-to-the-bacterial-iron-import-protein-efeo
#9
Kanate Temtrirath, Kenji Okumura, Yukie Maruyama, Bunzo Mikami, Kousaku Murata, Wataru Hashimoto
The tripartite EfeUOB system functions as a low pH iron importer in Gram-negative bacteria. In the alginate-assimilating bacterium Sphingomonas sp. strain A1, an additional EfeO-like protein (Algp7) is encoded downstream of the efeUOB operon. Here we show the metal binding mode of Algp7, which carries a M_75 metallopeptidase motif. The Algp7 protein was purified from recombinant E. coli cells and was subsequently characterized using differential scanning fluorimetry, fluorescence spectrometry, atomic absorption spectroscopy, and X-ray crystallography...
September 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28914298/folic-acid-on-iron-oxide-nanoparticles-platform-with-high-potential-for-simultaneous-targeting-mri-detection-and-hyperthermia-treatment-of-lymph-node-metastases-of-prostate-cancer
#10
Debora Bonvin, Jessica A M Bastiaansen, Matthias Stuber, Heinrich Hofmann, Marijana Mionić Ebersold
The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, very little has been reported for the targeting of nanomedicines to lymph node metastases (LNMs) of prostate cancer. We here report the simple and aqueous coating of iron oxide nanoparticles (IONPs) with FA for theranostics of LNMs of prostate cancer. FA was directly bound to the IONPs' surface without the use of any linker, simultaneously playing the role of the coating molecule and targeting agent...
September 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28910529/metal-ion-distribution-and-oxygen-vacancies-determine-activity-of-magnetically-recoverable-catalysts-in-methanol-synthesis
#11
Troy Oracko, Rigel Jaquish, Yaroslav B Losovyj, David Gene Morgan, Maren Pink, Barry D Stein, Valentin Yu Doluda, Olga P Tkachenko, Zinaida B Shifrina, Maxim E Grigoriev, Alexander I Sidorov, Esther M Sulman, Lyudmila M Bronstein
Here, we report on the development of novel Zn-, Zn-Cr-, and Zn-Cu-containing catalysts using magnetic silica (Fe3O4-SiO2) as support. Transmission electron microscopy, X-ray powder diffraction, and X-ray photoelectron spectroscopy showed that the iron oxide nanoparticles (NPs) are located in mesoporous silica pores and the magnetite (spinel) structure remains virtually unchanged despite the incorporation of Zn and Cr. According to X-ray photoelectron spectroscopy data, the Zn and Cr species are intermixed within the magnetite structure...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28906436/development-and-evaluation-of-a-manganese-and-iron-food-frequency-questionnaire-for-pediatrics
#12
Frida B Zipkin, Grace A Falciglia, Pierce Kuhnell, Erin N Haynes
Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children's growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum...
September 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28905202/drug-interactions-in-users-of-tablet-vs-oral-liquid-levothyroxine-formulations-a-real-world-evidence-study-in-primary-care
#13
Valeria Guglielmi, Alfonso Bellia, Elisa Bianchini, Gerardo Medea, Iacopo Cricelli, Paolo Sbraccia, Davide Lauro, Claudio Cricelli, Francesco Lapi
PURPOSE: Several medications may interact with levothyroxine (LT4) intestinal absorption or metabolism, thus reducing its bioavailability. We investigated the variability of thyroid stimulating hormone (TSH) levels and prescribed daily dosages (PDDs) of LT4 before and during potential drug-drug interactions (DDIs) in users of tablets vs. oral liquid LT4 formulations. METHODS: By using the Italian general practice Health Search Database (HSD), we retrospectively selected adult patients with at least one LT4 prescription from 2012 to 2015 and at least 1 year of clinical history recorded...
September 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28904291/concentration-dependent-roles-of-dmt1-and-zip14-in-cadmium-absorption-in-caco-2-cells
#14
Hitomi Fujishiro, Satoko Hamao, Rina Tanaka, Taiho Kambe, Seiichiro Himeno
Intestinal absorption of cadmium (Cd) is considered to be mediated mainly by the ferrous iron transporter DMT1, or the calcium transporter CaT1. The roles of zinc transporters such as ZIP8 and ZIP14 remain unclear, and the roles of these four transporters in the intestinal uptake of Cd under physiological conditions have not been compared. Here, we used a trans-well cell culture system to investigate the effects of the down-regulation of these four transporters on the uptake of Cd from the apical side of enterocytes...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28902207/preparation-and-characterization-of-crfewtio2-photoanodes-and-their-photoelectrochemical-activities-for-water-splitting
#15
Mohamad Mohsen Momeni, Yousef Ghayeb, Mojgan Shafiei
The chemical bath deposition (CBD) method was successfully applied to prepare WTiO2 nanotube arrays co-deposited with chromium, iron and chromium-iron nanoparticles. Various methods have been used in the characterization of synthetic co-deposited nanostructures. WTiO2 nanotubes can keep the nanotubular structures at low iron concentration in the CBD solution, as indicated by our FESEM results. Iron and chromium can be applied to improve the absorption capability of the WTiO2 nanotubes for the visible-light, according to the UV-Vis results...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28902140/iron-absorption-from-three-commercially-available-supplements-in-gastrointestinal-cell-lines
#16
Francesca Uberti, Vera Morsanuto, Sabrina Ghirlanda, Claudio Molinari
This study compares the absorption characteristics of two iron-based dietary supplements and their biocompatibility to bisglycinate iron, a common chelated iron form. The Caco-2 cell line-a model of human intestinal absorption-and GTL-16 cell line-a model of gastric epithelial cells-were used to perform the experiments; in the first experiments, the kinetics of absorption have been evaluated analyzing the divalent metal transporter 1 (DMT1) expression. Three different iron combinations containing 50 µM iron (named Fisioeme(®), Sideral(®) and bisglycinate) were used for different stimulation times (1-24 h)...
September 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28900262/microwave-properties-of-the-single-layer-periodic-structure-composites-composed-of-ethylene-vinyl-acetate-and-polycrystalline-iron-fibers
#17
Zhibo Guo, Hailong Huang, Ding Xie, Hui Xia
A single-layer microwave absorbing structure composed of the ethylene-vinyl acetate (EVA) powders and polycrystalline iron fibers (PIFs) with thickness of 2 mm, which has a periodic array of circular hole, is designed and fabricated using the mechanical method. We show that the reflection loss (RL) can be easily adjusted by changing the geometric parameters. The maximum RL is 18.7 dB at 15 GHz, and the effective absorption bandwidth of 1.7 GHz for the diameter of circular hole is 10 mm, and enhanced to be 23...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889268/aluminum-and-alzheimer-s-disease
#18
Maria Teresa Colomina, Fiona Peris-Sampedro
Aluminum (Al) is one of the most extended metals in the Earth's crust. Its abundance, together with the widespread use by humans, makes Al-related toxicity particularly relevant for human health.Despite some factors influence individual bioavailability to this metal after oral, dermal, or inhalation exposures, humans are considered to be protected against Al toxicity because of its low absorption and efficient renal excretion. However, several factors can modify Al absorption and distribution through the body, which may in turn progressively contribute to the development of silent chronic exposures that may lately trigger undesirable consequences to health...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28884376/environmental-risk-assessment-of-lead-zinc-mining-a-case-study-of-adudu-metallogenic-province-middle-benue-trough-nigeria
#19
Ogbonnaya Igwe, Chuku Okoro Una, Ezekiel Abu, Ekundayo Joseph Adepehin
Assessment of the impacts of lead-zinc mining in Adudu-Imon metallogenic province was carried out. Reconnaissance and detailed field studies were done. Lithologies, stream sediments, farmland soils, mine tailings, artificial pond water, stream water, well water, and borehole water were collected and subjected to atomic absorption spectrometry (AAS) and X-ray fluorescence (XRF) analyses. Geochemical maps were generated using ArcGIS 10.1. Significant contamination with cadmium (Cd), iron (Fe), and lead (Pb) was recorded in the collected water samples...
September 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28884360/calcium-and-zinc-decrease-intracellular-iron-by-decreasing-transport-during-iron-repletion-in-an-in-vitro-model
#20
Andrews Mónica, Briones Lautaro, Pizarro Fernando, Arredondo Miguel
PURPOSE: Iron is an essential micronutrient that participates in a number of vital reactions and its absorption may be altered by various nutritional factors such as other micronutrients. Our hypothesis is that iron absorption is decreased because of the interactions with zinc and calcium. We evaluated the interaction between calcium and zinc on iron uptake and transport, intracellular Fe and Zn levels and mRNA expression of DMT1, ferroportin, Zip4 and ZnT1 in an in vitro model. METHODS: Caco-2 cells were cultivated with 1 mM Ca; 10 or 30 µM Zn and/or 10, 20 or 30 µM Fe for 24 h...
September 7, 2017: European Journal of Nutrition
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