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Iron absorption

Laurence Britton, Lesley-Anne Jaskowski, Kim Bridle, Eriza Secondes, Daniel Wallace, Nishreen Santrampurwala, Janske Reiling, Gregory Miller, Salvatore Mangiafico, Sofianos Andrikopoulos, V Nathan Subramaniam, Darrell Crawford
Background & Aims: Iron has an increasingly recognized role in the regulation of adipose tissue function, including the expression of adipokines involved in the pathogenesis of nonalcoholic fatty liver disease. The cellular iron exporter, ferroportin, has been proposed as being a key determinant of adipocyte iron homeostasis. Methods: We studied an adipocyte-specific ferroportin ( Fpn1 ) knockout mouse model, using an Adipoq -Cre recombinase driven Fpn1 deletion and fed mice according to the fast food diet model of nonalcoholic steatohepatitis...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
Kalyani Raju, Srinivas Murthy Venkataramappa
Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance...
January 2018: International Journal of Applied and Basic Medical Research
Guillaume Dubeaux, Julie Neveu, Enric Zelazny, Grégory Vert
Plant roots forage the soil for iron, the concentration of which can be dramatically lower than those needed for growth. Soil iron uptake uses the broad metal spectrum IRT1 transporter that also transports zinc, manganese, cobalt, and cadmium. Sophisticated iron-dependent transcriptional regulatory mechanisms allow plants to tightly control the abundance of IRT1, ensuring optimal absorption of iron. Here, we uncover that IRT1 acts as a transporter and receptor (transceptor), directly sensing excess of its non-iron metal substrates in the cytoplasm, to regulate its own degradation...
March 15, 2018: Molecular Cell
Takahiko Kojima, Fumiya Ogishima, Takahisa Nishibu, Hiroaki Kotani, Tomoya Ishizuka, Toshihiro Okajima, Shunsuke Nozawa, Yoshihito Shiota, Kazunari Yoshizawa, Hiroyoshi Ohtsu, Masaki Kawano, Takuya Shiga, Hiroki Oshio
An iron(III) complex having a dibenzotetraethyltetraamido macrocyclic ligand (DTTM4- ), (NEt4 )2 [FeIII (DTTM)Cl] (1), was synthesized and characterized by crystallographic, spectroscopic, and electrochemical methods. Complex 1 has a square-pyramidal structure in the S =3 /2 spin state. The complex exhibited two reversible redox waves at +0.36 and +0.68 V (vs SCE) in the cyclic voltammogram measured in CH2 Cl2 at room temperature. The stepwise oxidation of 1 using chemical oxidants allowed us to observe clear and distinct spectral changes with distinct isosbestic points for each step, in which oxidation occurred at the phenylenediamido moiety rather than the iron center...
March 16, 2018: Inorganic Chemistry
Altair B Dos Santos, Kristi A Kohlmeier, Marcelo E Rocha, George E Barreto, Jeferson A Barreto, Ana Carla A de Souza, Marcos A Bezerra
Imbalances in metals have emerged as playing a role in the pathophysiology of Parkinson's Disease (PD). Monitoring of metal levels could serve as a biomarker of presence, or future development, of this disease. To this end, we evaluated the ability of flame atomic absorption spectrometry (FAAS) to assess the concentrations of Ca, Fe and Zn in hair of PD patients and to investigate if there was an association with age and disease duration. Hair samples were collected from 26 clinically-diagnosed PD patients, and 33 healthy individuals...
May 2018: Journal of Trace Elements in Medicine and Biology
A Charnukha, D Pröpper, N D Zhigadlo, M Naito, M Schmidt, Zhe Wang, J Deisenhofer, A Loidl, B Keimer, A V Boris, D N Basov
We report the first determination of the in-plane complex optical conductivity of 1111 high-T_{c} superconducting iron oxypnictide single crystals PrFeAs(O,F) and thin films SmFeAs(O,F) by means of conventional and microfocused infrared spectroscopy, ellipsometry, and time-domain THz transmission spectroscopy. A strong itinerant contribution is found to exhibit a dramatic difference in coherence between the crystal and the film. Using extensive temperature-dependent measurements of THz transmission, we identify a previously undetected 2...
February 23, 2018: Physical Review Letters
Elizabeth S Ryland, Ming-Fu Lin, Max A Verkamp, Kaili Zhang, Kristin Benke, Michaela Carlson, Josh Vura-Weis
Iron porphyrins are the active sites of many natural and artificial catalysts, and their photoinduced dynamics have been described as either relaxation into a vibrationally hot ground state or as a cascade through metal-centered states. In this work, we directly probe the metal center of iron(III) tetraphenyl porphyrin chloride (FeTPPCl) using femtosecond M2,3 -edge x-ray absorption near-edge structure (XANES) spectroscopy. Photoexcitation at 400 nm produces a (π, π*) state that evolves in 70 fs to an iron(II) ligand-to-metal charge transfer (LMCT) state...
March 14, 2018: Journal of the American Chemical Society
Jingsi Cheng, Ping Wang, Chao Hua, Yintang Yang, Zhiyong Zhang
The structural stability, electronic structure, and optical properties of an iron-adsorbed ZnO (0001) surface with three high-symmetry adsorption sites are investigated with first-principle calculations on the basis of density functional theory and the Hubbard-U method. It is found that the iron adatom in the H₃ adsorption site of ZnO (0001) surface has the lowest adsorption energy of -5.665 eV compared with T₄ and Top sites. For the Top site, compared with the pristine ZnO (0001) surface, the absorption peak located at 1...
March 12, 2018: Materials
Christopher R D'Adamo, James S Novick, Termeh M Feinberg, Valerie J Dawson, Larry E Miller
OBJECTIVE: Iron deficiency is the most common nutrient deficiency in the world. While deficiency can often be resolved through dietary supplementation with iron, adverse events are common and frequently preclude compliance. The objective of this study was to determine whether a food-derived dietary supplement containing a low dose of iron and nutrients that increase iron absorption could resolve iron deficiency with fewer adverse events than reported at higher doses. METHODS: A pilot clinical trial (NCT02683369) was conducted among premenopausal women with nonanemic iron deficiency that was verified by blood screening...
March 13, 2018: Journal of the American College of Nutrition
Dmitri V Konarev, Alexey V Kuzmin, Yoshiaki Nakano, Salavat S Khasanov, Akihiro Otsuka, Hideki Yamochi, Hiroshi Kitagawa, Rimma N Lyubovskaya
N-Methylimidazole (MeIm) solvates of vanadium(ii), chromium(ii) and iron(ii) phthalocyanines: [VII (MeIm)2 (Pc2- )]0 ·MeIm (1) and [MII (MeIm)2 (Pc2- )]0 ·2C6 H4 Cl2 (M = V (2), Cr (3), and Fe (4)) have been obtained and studied in a crystalline form. It has been shown that central metal atoms have the +2 oxidation state in 1-4 and dianionic Pc2- macrocycles are formed. Optical spectra of 1-3 (VII , CrII ) are different from that of 4 (FeII ) due to the appearance of intense absorption bands in the NIR range at 1187 nm for 1 and 2 and 1178 nm for 3 and manifestation of multiple bands in the visible range...
March 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Aline Maire du Poset, Adrien Lerbret, Andrea Zitolo, Fabrice Cousin, Ali Assifaoui
We designed stable and highly reproducible hydrogels by external unidirectional diffusion of Fe2+ ions into aqueous solutions of polygalacturonate (polyGal) chains. The Fe2+ ions act as cross-linkers between the Gal units in such a way that both the molar ratio R ([Fe2+ ]/[Gal units] = 0.25) and the mesh size of the polyGal network at the local scale (ξ = 75 ± 5 Å) have constant values within the whole gel, as respectively determined by titration and Small Angle Neutron Scattering. From macroscopic point of view, there is a progressive decrease of polyGal concentration from the part of the gel formed in the early stages of the gelation process, which is homogeneous, transparent and whose Young modulus has a high value of ∼105  Pa, up to the part of the gel formed in the late stages, which is heterogeneous, highly turbid and has a much lower Young modulus of ∼103  Pa...
May 15, 2018: Carbohydrate Polymers
Carla Casu, Elizabeta Nemeth, Stefano Rivella
Hepcidin agonists are a new class of compounds that regulate blood iron levels and limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders where disrupted iron homeostasis causes disease or contributes to it. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders...
March 9, 2018: Blood
Ziling Peng, Chunmei Xiong, Wei Wang, Fatang Tan, Xinyun Wang, Xueliang Qiao, Po Keung Wong
Usually, nanoscale zero-valent iron (NZVI) cannot float on water because of high density and hydrophilic surface. Herein, alkyltrimethoxysilanes with different carbon chain lengths (C1, C8 and C16) were used as "water-repellent legs" to graft onto NZVI, enduing NZVI with hydrophobic and floatable characteristics like a water strider. The hydrophobic performance of as-modified NZVI materials was found to be better when NZVI was modified by alkyltrimethoxysilane with longer carbon chain, and a large contact angle of 151...
February 27, 2018: Chemosphere
Vera Cuartero, Javier Blasco, Gloria Subías, Joaquín García, José A Rodríguez-Velamazán, Clemens Ritter
The effect of substituting iron and zinc for cobalt in CaBaCo4 O7 was investigated using neutron diffraction and X-ray absorption spectroscopy techniques. The orthorhombic distortion present in the parent compound CaBaCo4 O7 decreases with increasing the content of either Fe or Zn. The samples CaBaCo3 ZnO7 and CaBaCo4- x Fex O7 with x ≥ 1.5 are metrically hexagonal, but much better refinements in the neutron diffraction patterns are obtained using an orthorhombic unit cell. The two types of substitution have opposite effects on the structural and magnetic properties...
March 8, 2018: Inorganic Chemistry
Hayley Simon, Giannantonio Cibin, Phil Robbins, Sarah Day, Chiu Tang, Ian Freestone, Eleanor Schofield
Post-excavation iron corrosion may be accelerated by the presence of Cl- , leading to conservation methods designed to remove Cl. This study exploits a unique opportunity to assess 35 years of conservation applied to cast-iron cannon shot excavated from the Mary Rose. A combination of synchrotron X-ray powder diffraction (SXPD), absorption spectroscopy (XAS), and fluorescence (XRF) mapping have been used to characterise the impact of conservation on the crystalline corrosion products, chlorine distribution, and speciation...
March 8, 2018: Angewandte Chemie
Ari Dwi Nugraheni, Chunguang Ren, Yorifumi Matsumoto, Satoshi Nagao, Masaru Yamanaka, Shun Hirota
The Met80-heme iron bond of cytochrome c (cyt c) is cleaved by the interaction of cyt c with cardiolipin (CL) in membranes. The Met80 dissociation enhances the peroxidase activity of cyt c and triggers cyt c release from mitochondrion to the cytosol at the early stage of apoptosis. This paper demonstrates the selective oxidation of Met80 for the reaction of ferric cyt c with a peroxide, meta-chloroperbenzoic acid (mCPBA), in the presence of CL-containing liposomes by formation of a ferryl species (Compound I)...
February 24, 2018: Journal of Inorganic Biochemistry
Anla Hu, Li Li, Chuanlai Hu, Daoming Zhang, Chen Wang, Yan Jiang, Meng Zhang, Chunmei Liang, Wenjun Chen, Qingli Bo, Qihong Zhao
Helicobacter pylori (H. pylori) infection can interfere with the absorption of most elements, and the variations of some element levels are related to the incidence of gastric cancer. However, there have been conflicting results concerning the influence of H. pylori infection on serum element levels. The present study aimed to compare the serum element concentrations of H. pylori-infected local residents with uninfected residents from Lujiang County with high gastric cancer risk in Eastern China. We used data and serum samples from the H...
March 3, 2018: Biological Trace Element Research
Stéphane L Benoit, Ashley A Holland, Michael K Johnson, Robert J Maier
Helicobacter pylori is anomalous among non-nitrogen fixing bacteria in containing an incomplete NIF system for Fe-S cluster assembly comprising two essential proteins, NifS (cysteine desulfurase) and NifU (scaffold protein). Although nifU deletion strains cannot be obtained via the conventional gene replacement, a NifU-depleted strain was constructed and shown to be more sensitive to oxidative stress compared to wild-type (WT) strains. The hp1492 gene, encoding a putative Nfu-type Fe-S cluster carrier protein, was disrupted in three different H...
March 2, 2018: Molecular Microbiology
Pavel Kucheryavy, Nicole Lahanas, Jenny V Lockard
A systematic comparison of host-guest interactions in two iron porphyrin-based metal-organic frameworks (MOFs), FeCl-PCN222 and FeCl-PCN224, with drastically different pore sizes and geometries is reported in this fundamental spectroscopy study. Guest molecules (acetone, imidazole, and piperidine) of different sizes, axial binding strengths, and reactivity with the iron porphyrin centers are employed to demonstrate the range of possible interactions that occur at the porphyrin sites inside the pores of the MOF...
March 1, 2018: Inorganic Chemistry
Yukina Nishito, Taiho Kambe
Essential trace elements play pivotal roles in numerous structural and catalytic functions of proteins. Adequate intake of essential trace elements from the daily diet is indispensable to the maintenance of health, and their deficiency leads to a variety of conditions. However, excessive amounts of these trace elements may be highly toxic, and in some cases, may cause damage by the production of harmful reactive oxygen species. Homeostatic dysregulation of their metabolism increases the risk of developing diseases...
2018: Journal of Nutritional Science and Vitaminology
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