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Iron absorption

Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
Binh T T Pham, Emily K Colvin, Nguyen T H Pham, Byung J Kim, Emily S Fuller, Elizabeth A Moon, Raphael Barbey, Samuel Yuen, Barry H Rickman, Nicole S Bryce, Stephanie Bickley, Marcel Tanudji, Stephen K Jones, Viive M Howell, Brian S Hawkett
Nanomedicine is an emerging field with great potential in disease theranostics. We generated sterically stabilized superparamagnetic iron oxide nanoparticles (s-SPIONs) with average core diameters of 10 and 25 nm and determined the in vivo biodistribution and clearance profiles. Healthy nude mice underwent an intraperitoneal injection of these s-SPIONs at a dose of 90 mg Fe/kg body weight. Tissue iron biodistribution was monitored by atomic absorption spectroscopy and Prussian blue staining. Histopathological examination was performed to assess tissue toxicity...
January 10, 2018: International Journal of Molecular Sciences
Yuko Tsutsui, Kazuo Kobayashi, Fusako Takeuchi, Motonari Tsubaki, Takahiro Kozawa
Nitric oxide synthase (NOS) is a cytochrome P450-type mono-oxygenase that catalyzes the oxidation of L-arginine (Arg) to nitric oxide (NO) through a reaction intermediate N-hydroxy-L-arginine (NHA). The mechanism underlying the reaction catalyzed by NOS from Deinococcus radiodurans was investigated using pulse radiolysis. Radiolytically-generated hydrated electrons reduced the heme iron of NOS within 2 μs. Subsequently, ferrous heme reacted with O2 to form a ferrous-dioxygen intermediated with a second-order rate constant of 2...
January 10, 2018: Biochemistry
P Guardia, S Nitti, M E Materia, G Pugliese, N Yaacoub, J-M Greneche, C Lefevre, L Manna, T Pellegrino
With the aim of producing Au-Fe x O y dimers with outstanding heating performances under magnetic hyperthermia conditions applicable to human patients, here we report two synthesis routes, a two-pot and a one-pot method. The addition of chloride ions and the absence of 1,2-hexadecanediol (HDDOL), a commonly used chemical in this synthesis, are the key factors that enable us to produce dimers at low temperature with crystalline iron oxide domains in the size range between 18-39 nm that is ideal for magnetic hyperthermia...
June 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Cecile S Bonifacio, Gautom Das, Ian M Kennedy, Klaus van Benthem
The reduction reactions and densification of nanochains assembled from γ-Fe2O3 nanoparticles were investigated using in situ transmission electron microscopy (TEM). Morphological changes and reduction of the metal oxide nanochains were observed during in situ TEM annealing through simultaneous imaging and quantitative analysis of the near-edge fine structures of Fe L2,3 absorption edges acquired by spatially resolved electron energy loss spectroscopy. A change in the oxidation states during annealing of the iron oxide nanochains was observed with phase transformations due to continuous reduction from Fe2O3 over Fe3O4, FeO to metallic Fe...
December 21, 2017: Journal of Applied Physics
Aparajita Chowdhury, Lora L Arnold, Zemin Wang, Karen L Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E Klaunig, Daniel Cros, Edmond E Creppy, Samuel M Cohen
Polyhexamethylene biguanide (PHMB), an amphiphilic polymeric biocide, increased liver tumor incidence in male and female rats at 1000 and 1500 mg/l in drinking water, but not at 500 mg/l in previous studies. In another study, PHMB administered in diet at 4000 mg/kg was negative for hepatocellular tumors. The present studies evaluated bioavailability and distribution of PHMB administered in drinking water and diet and possible modes of action (MOA). PHMB in drinking water was unpalatable during the first 3 days, resulting in markedly decreased food consumption and decreased body weight...
January 2, 2018: Toxicology Letters
Jinli Cui, Jingjing Du, Haixia Tian, Tingshan Chan, Chuanyong Jing
Microorganisms play a key role in the redox transformation of arsenic (As) in aquifers. In this study, the impact of indigenous bacteria, especially the prevailing nitrate respirers, on arsenite (As(III)) oxidation was explored during groundwater filtration using granular TiO2 and subsequent spent TiO2 anaerobic landfill. X-ray absorption near edge structure spectroscopy analysis showed As(III) oxidation (46% in 10 days) in the presence of nitrate in the simulated anaerobic landfills. Meanwhile, iron (Fe) species on the spent TiO2 were dominated by amorphous ferric arsenate, ferrihydrite and goethite...
December 27, 2017: Chemosphere
Maja Arsic, Peter R Teasdale, David Thomas Welsh, Scott G Johnston, Edward D Burton, Kerstin Hockmann, William Walpole Bennett
Antimony (Sb) and arsenic (As) are priority environmental contaminants that often co-occur at mining-impacted sites. Despite their chemical similarities, Sb mobility in waterlogged sediments is poorly understood in comparison to As, particularly across the sediment-water interface (SWI) where changes can occur at the millimetre scale. Combined diffusive gradients in thin films (DGT) and diffusive equilibration in thin films (DET) techniques provided a high resolution, in situ comparison between Sb, As and iron (Fe) speciation and mobility across the SWI in contaminated freshwater wetland sediment mesocosms under an oxic-anoxic-oxic transition...
January 5, 2018: Environmental Science & Technology
Paula Fernanda Silva Fonseca, Rodolfo Delfini Cançado, Flavio Augusto Naoum, Carla Luana Dinardo, Guilherme Henrique Hencklain Fonseca, Sandra Fatima Menosi Gualandro, José Eduardo Krieger, Alexandre Costa Pereira, Pierre Brissot, Paulo Caleb Junior Lima Santos
BACKGROUND: Hereditary hemochromatosis (HH) encompasses a group of autosomal recessive disorders mainly characterized by enhanced intestinal absorption of iron and its accumulation in parenchymal organs. HH diagnosis is based on iron biochemical and magnetic resonance imaging (MRI) assessment, and genetic testing. Questionnaires, such as SF-36 (short form health survey), have been increasingly used to assess the impact of diseases on the patient's quality of life (QL). In addition, different genotypes are identified as results of genetic tests in patients with suspected primary iron overload...
January 5, 2018: BMC Medical Genetics
Jun Wang, Gabor Radics, Michael Whelehan, Aoibhe OʼDriscoll, Anne Marie Healy, John F Gilmer, Mark Ledwidge
BACKGROUND: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. METHODS: We evaluated novel iron-denatured whey protein (Iron-WP) microspheres on reactive oxygen species (ROS) and viability in gut epithelial (HT29) cells. We compared iron absorption from Iron-WP versus equimolar-dose (25 mg elemental iron) ferrous sulphate (FeSO4) in a prospective, randomised, cross-over study in fasting volunteers (n = 21 per group) dependent on relative iron depletion (a ferritin level ≤/>30 ng/mL)...
January 5, 2018: Acta Haematologica
Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Zhen Guo, Haibao Wang, Qianwang Chen
Phothermal therapy has received increasing attention in recent years as a potentially effective way for treatment of cancer. In pursuit of a more biocompatible photothermal agent, we utilize bio-safe materials-ellagic acid (EA), polyvinyl pyrrolidone (PVP) and iron element as the building blocks, and successfully fabricate homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nano-agent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo...
January 4, 2018: ACS Applied Materials & Interfaces
Shiliang Wang, Bingbing Liang, Daitao Kuang, Lizhen Hou, Bowen Yu, Liang Wu Lin, Lianwen Deng, Han Huang, He Jun
FeCo-C core-shell nanoparticles with diameters of 10 - 50 nm have been fabricated on a large scale by one-step metal-organic chemical vapor deposition using the mixture of cobalt acetylacetonate and iron acetylacetonate as the precursor. The Fe/Co molar ratio of the alloy nanocores and graphitization degree of C shells, and thus the magnetic and electric properties of the core-shell nanoparticles, can be tuned by the deposition temperature ranged from 700 to 900 oC. Comparative tests reveal that a relatively high Fe/Co molar ratio and low graphitization degree benefit the microwave absorption performance of the core-shell nanoparticles...
January 4, 2018: Nanotechnology
Pavel Chabera, Kasper S Kjær, Om Prakash, Alireza Honarfar, Yizhu Liu, Lisa A Fredin, Tobias B Harlang, Sven Lidin, Jens Uhlig, Villy Sundstrom, Reiner Lomoth, Petter Persson, Kenneth Wärnmark
The iron carbene complex [FeII(btz)3]2+ (where btz = 3,3'-dimethyl-1,1'-bis(p-tolyl)-4,4'-bis(1,2,3-triazol-5-ylidene)) has been synthesized, isolated and characterized as a low-spin ferrous complex. It exhibits strong metal-to-ligand charge transfer (MLCT) absorption bands throughout the visible spectrum, and excitation of these bands gives rise to a 3MLCT state with a 528 ps excited state lifetime in CH3CN solution that is more than one order of magnitude longer compared to the MLCT lifetime of any previously reported FeII complex...
January 3, 2018: Journal of Physical Chemistry Letters
Caglar Doguer, Jung-Heun Ha, Sukru Gulec, Chris D Vulpe, Gregory J Anderson, James F Collins
Regulation of intestinal iron absorption is crucial to maintain body iron levels because humans have no regulated iron-excretory system. Elucidating molecular events that mediate intestinal iron transport is thus important for the development of therapeutic approaches to modify iron absorption in pathological states. The process of iron uptake into duodenal enterocytes is relatively well understood, but less is known about the functional coupling between the iron exporter ferroportin 1 and the basolateral membrane iron oxidase hephaestin (Heph)...
July 25, 2017: Blood Advances
Ganeshlenin Kandasamy, Atul Sudame, Piyush Bhati, Anindita Chakrabarty, S N Kale, Dipak Maity
We have systematically studied heating efficiencies (via specific absorption rate-SAR/intrinsic loss power-ILP) of carboxyl (terephthalic acid-TA) functionalized hydrophilic SPIONs based ferrofluids (with good biocompatibility/high magnetization) and influence of following key factors in magnetic fluid hyperthermia (MFH): (i) alternating magnetic fields (AMFs - H)/frequencies (f) - chosen below/above Hergt's biological safety limit, (ii) concentrations (0.5-8 mg/ml) and (iii) dispersion media (water, a cell-culture medium and triethylene glycol (TEG)) for in vitro cancer therapy...
December 24, 2017: Journal of Colloid and Interface Science
Rui Lei, Hongwei Ni, Rongsheng Chen, Huazhi Gu, Bowei Zhang, Weiting Zhan
As an n-type semiconductor with an excellent physicochemical properties, iron oxide (Fe2O3) has been extensively used in the fields of environmental pollution control and solar energy conversion. However, the high recombination rate of the photoinduced electron-hole pairs and poor charge mobility for Fe2O3 nanomaterial generally result in low photocatalytic efficiency. Herein, an uniform CdS nanorods grown directly on one-dimensional α-Fe2O3 nanotube arrays (NTAs) are successfully synthesized by a facile hydrothermal method and the constructed heterojunction can be a kind of efficient and recyclable photocatalysts...
December 24, 2017: Journal of Colloid and Interface Science
Young-Soo Han, Hye Jin Seong, Chul-Min Chon, Jin Hee Park, In-Hyun Nam, Kyoungkeun Yoo, Joo Sung Ahn
This study examined the reaction mechanism of arsenite, As(III), and antimonite, Sb(III), with iron sulfide and compared their pH-dependent reaction behaviors under strictly anoxic environments. The comparison of Sb(III) with As(III), based on their chemical similarity, may provide useful insight into understanding the geochemical behavior of the less studied Sb(III). The pH-dependent batch sorption studies revealed that As(III) and Sb(III) displayed similar removal trends with pH in terms of the removal efficiency...
December 26, 2017: Chemosphere
Owen M Wilkin, Neil Harris, John F Rooms, Emma L Dixon, Adam J Bridgeman, Nigel Andrew Young
The interaction of FeBr2, CoBr2, NiBr2 and ZnBr2 with Ne, Ar, Kr, Xe, CH4 and N2 matrices has been investigated using IR, electronic absorption and X-ray absorption spectroscopies, as well as DFT calculations. ZnBr2 is linear in all the matrices. NiBr2 is linear in all but N2 matrices where it is severely bent. For FeBr2 and CoBr2 there is a more gradual change, with evidence of non-linearity in Xe and CH4 matrices as well as N2. In the N2 matrices the presence of νNN modes blue shifted from the "free" N2 values indicates the presence of physisorbed species, and the magnitude of the blue-shift correlates with the shift in the ν3 mode of the metal dibromide...
December 28, 2017: Journal of Physical Chemistry. A
Charles R Pedlar, Carlo Brugnara, Georgie Bruinvels, Richard Burden
Maintaining a positive iron balance is essential for female athletes to avoid the effects of iron deficiency and anaemia and to maintain or improve performance. A major function of iron is in the production of the oxygen and carbon dioxide carrying molecule, haemoglobin, via erythropoiesis. Iron balance is under the control of a number of factors including the peptide hormone hepcidin, dietary iron intake and absorption, environmental stressors (e.g. altitude), exercise, menstrual blood loss and genetics. Menstruating females, particularly those with heavy menstrual bleeding are at an elevated risk of iron deficiency...
December 27, 2017: European Journal of Sport Science
Heidi M Staudacher, Matthew Kurien, Kevin Whelan
PURPOSE OF REVIEW: The aim of this review is to summarize some of the key dietary interventions recommended for common gastrointestinal disorders and to discuss recent evidence regarding their nutritional implications. RECENT FINDINGS: The gluten-free diet has been shown to negatively influence overall diet quality. The gluten-free diet is essential in celiac disease, although it is increasingly used for other perceived health benefits for which an analysis of perceived benefit should be weighed against any nutritional risks...
December 22, 2017: Current Opinion in Gastroenterology
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