Shimin Tao, Mingjun Yang, Bin Pan, Yuzhu Wang, Fang Tian, Dongyang Han, Wenpu Shao, Wenhui Yang, Yuanting Xie, Xinyi Fang, Minjie Xia, Jingying Hu, Haidong Kan, Weihua Li, Yanyi Xu
Epidemiological and animal studies have shown that maternal fine particulate matters (PM2.5 ) exposure correlates with various adverse pregnancy outcomes such as low birth weight (LBW) of offspring. However, the underlying biological mechanisms have not been fully understood. In this study, female C57Bl/6 J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) during pregestational and gestational periods, and metabolomics was performed to analyze the metabolic features in maternal serum and placenta by liquid chromatography-mass spectrometry (LC-MS)...
October 28, 2022: Environmental Research