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https://www.readbyqxmd.com/read/28805173/latent-traits-of-impulsivity-and-compulsivity-toward-dimensional-psychiatry
#1
S R Chamberlain, J Stochl, S A Redden, J E Grant
BACKGROUND: The concepts of impulsivity and compulsivity are commonly used in psychiatry. Little is known about whether different manifest measures of impulsivity and compulsivity (behavior, personality, and cognition) map onto underlying latent traits; and if so, their inter-relationship. METHODS: A total of 576 adults were recruited using media advertisements. Psychopathological, personality, and cognitive measures of impulsivity and compulsivity were completed...
August 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28799558/intermittent-mydriasis-associated-with-carotid-vascular-occlusion
#2
P D Chamberlain, A Sadaka, S Berry, A G Lee
PurposeTo describe two cases of stereotyped, intermittent, neurologically isolated, unilateral mydriasis in patients with a history of acquired internal carotid artery (ICA) occlusive disease on the ipsilateral side.PatientsTwo patients with intermittent mydriasis.MethodsCase Series.ResultsCase one: A 78-year-old man experienced 10 episodes of intermittent, unilateral, and painless mydriasis in the left eye and had 100% occlusion of the left ICA artery due to atherosclerotic disease. Case two: A 26-year-old woman with history of migraine developed new painless, intermittent episodes of unilateral mydriasis after sustaining chest trauma and was diagnosed with subsequent dissection and 65% occlusion of the ipsilateral ICA...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28798863/pollination-success-following-loss-of-a-frequent-pollinator-the-role-of-compensatory-visitation-by-other-effective-pollinators
#3
Allysa C Hallett, Randall J Mitchell, Evan R Chamberlain, Jeffrey D Karron
Pollinator abundance is declining worldwide and may lower the quantity and quality of pollination services to flowering plant populations. Loss of an important pollinator is often assumed to reduce the amount of pollen received by stigmas of a focal species (pollination success), yet this assumption has rarely been tested experimentally. The magnitude of the effect, if any, may depend on the relative efficiency of the remaining pollinators, and on whether the loss of one pollinator leads to changes in visitation patterns by other pollinators...
May 2017: AoB Plants
https://www.readbyqxmd.com/read/28797723/left-ventricular-global-strain-analysis-by-two-dimensional-speckle-tracking-echocardiography-the-learning-curve
#4
Jonathan Chan, Kenji Shiino, Nchafatso G Obonyo, Joseph Hanna, Robert Chamberlain, Andrew Small, Isabel G Scalia, William Scalia, Akira Yamada, Christian R Hamilton-Craig, Gregory M Scalia, Jose Luis Zamorano
BACKGROUND: The application of left ventricular (LV) global strain by speckle-tracking is becoming more widespread, with the potential for incorporation into routine clinical echocardiography in selected patients. There are no guidelines or recommendations for the training requirements to achieve competency. The aim of this study was to determine the learning curve for global strain analysis and determine the number of studies that are required for independent reporting. METHODS: Three groups of novice observers (cardiology fellows, cardiac sonographers, medical students) received the same standardized training module prior to undertaking retrospective global strain analysis on 100 patients over a period of 3 months...
August 7, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28782060/impacts-of-interleukin-17-neutralization-on-the-inflammatory-response-in-a-healing-ligament
#5
Anna Eb Clements, Connie S Chamberlain, Ellen M Leiferman, William L Murphy, Ray Vanderby
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation...
May 2017: J Cytokine Biol
https://www.readbyqxmd.com/read/28780512/repeated-administration-of-dapirolizumab-pegol-in-a-randomised-phase-i-study-is-well-tolerated-and-accompanied-by-improvements-in-several-composite-measures-of-systemic-lupus-erythematosus-disease-activity-and-changes-in-whole-blood-transcriptomic-profiles
#6
Chris Chamberlain, Peter J Colman, Ann M Ranger, Linda C Burkly, Geoffrey I Johnston, Christian Otoul, Christian Stach, Miren Zamacona, Thomas Dörner, Murray Urowitz, Falk Hiepe
OBJECTIVES: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with diffuse immune cell dysfunction. CD40-CD40 ligand (CD40L) interaction activates B cells, antigen-presenting cells and platelets. CD40L blockade might provide an innovative treatment for systemic autoimmune disorders. We investigated the safety and clinical activity of dapirolizumab pegol, a polyethylene glycol conjugated anti-CD40L Fab' fragment, in patients with SLE. METHODS: This 32-week randomised, double-blind, multicentre study (NCT01764594) evaluated repeated intravenous administration of dapirolizumab pegol in patients with SLE who were positive for/had history of antidouble stranded DNA/antinuclear antibodies and were on stable doses of immunomodulatory therapies (if applicable)...
August 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28768144/the-c-terminal-domain-of-zdhhc2-contains-distinct-sorting-signals-that-regulate-intracellular-localisation-in-neurons-and-neuroendocrine-cells
#7
Christine Salaun, Louise Ritchie, Jennifer Greaves, Trevor J Bushell, Luke H Chamberlain
The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors. zDHHC2 is responsive to synaptic activity and catalyses the increased S-acylation of PSD95 that occurs following action potential blockade or application of ionotropic glutamate receptor antagonists. These treatments have been proposed to increase plasma membrane delivery of zDHHC2 via an endosomal cycling pathway, enhancing substrate accessibility. To generate an improved understanding of zDHHC2 trafficking and how this might be regulated by neuronal activity, we searched for intramolecular signals that regulate enzyme localisation...
July 30, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28765380/high-expenditure-pharmaceutical-use-among-children-in-medicaid
#8
Eyal Cohen, Matt Hall, Ruth Lopert, Brian Bruen, Lisa J Chamberlain, Naomi Bardach, Jennifer Gedney, Bonnie T Zima, Jay G Berry
BACKGROUND AND OBJECTIVES: Medication use may be a target for quality improvement, cost containment, and research. We aimed to identify medication classes associated with the highest expenditures among pediatric Medicaid enrollees and to characterize the demographic, clinical, and health service use of children prescribed these medications. METHODS: Retrospective, cross-sectional study of 3 271 081 Medicaid-enrolled children. Outpatient medication spending among high-expenditure medication classes, defined as the 10 most expensive among 261 mutually exclusive medication classes, was determined by using transaction prices paid to pharmacies by Medicaid agencies and managed care plans among prescriptions filled and dispensed in 2013...
August 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/28759559/ethambutol-optic-neuropathy
#9
Paul D Chamberlain, Ama Sadaka, Shauna Berry, Andrew G Lee
PURPOSE OF REVIEW: We provide a summary of the epidemiology, clinical findings, management and outcomes of ethambutol-induced optic neuropathy (EON). Ethambutol-induced optic neuropathy is a well-known, potentially irreversible, blinding but largely preventable disease. Clinicians should be aware of the importance of patient and physician education as well as timely and appropriate screening. RECENT FINDINGS: Two of the largest epidemiologic studies investigating EON to date showed the prevalence of EON in all patients taking ethambutol to be between 0...
July 28, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28746426/cranio-vertebral-transition-assessment-by-magnetic-resonance-imaging-in-a-sample-of-a-northeast-brazilian-population
#10
Heitor Cabral Frade, Caio César Nuto Leite França, José Jailson Costa do Nascimento, Maurus Marques de Almeida Holanda, Eulâmpio José da Silva, Severino Aires Araújo
Methods: Cross-sectional analysis of craniometric parameters from individuals submitted to magnetic resonance at an outpatient imaging center between 2011 and 2012. Results: Of 181 analyzed cases, the Welcker basal angle averaged 128.96º (SD 6.51), median distance between apex of the odontoid and Chamberlain's line was 2.27 mm (IQR -1.23-4.47) and the median clivus-canal angle was 150.5º (IQR 143.2-157.3). The Welcker basal angle was inversely correlated to the clivus-canal angle, and correlated to the distance between the apex of the odontoid and Chamberlain's line...
July 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28740422/preoperative-intravenous-ibuprofen-does-not-influence-postoperative-narcotic-use-in-patients-undergoing-elective-hernia-repair-a-randomized-double-blind-placebo-controlled-prospective-trial
#11
Lauren S Sparber, Christine Sm Lau, Tanya S Vialet, Ronald S Chamberlain
INTRODUCTION: Inguinal and umbilical hernia repairs are among the most common surgical procedures performed in the US. Optimal perioperative pain control regimens remain challenging and opioid analgesics are commonly used. Preoperative nonsteroidal anti-inflammatory drug (NSAID) administration has been shown to reduce postoperative narcotic requirements. This study sought to evaluate the efficacy of perioperative intravenous (IV) ibuprofen on postoperative pain level and narcotic use in patients undergoing open or laparoscopic inguinal and/or umbilical hernia repair...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28738097/impact-of-obsessive-compulsive-personality-disorder-symptoms-in-internet-users
#12
Samuel R Chamberlain, Sarah A Redden, Dan J Stein, Christine Lochner, Jon E Grant
BACKGROUND: Internet use is pervasive in many cultures. Little is known about the impact of obsessive-compulsive personality disorder (OCPD) symptoms on impulsive and compulsive psychopathologies in people who use the Internet. METHODS: Adult Internet users (N = 1,323) completed an online questionnaire quantifying OCPD symptoms, likely occurrence of select mental disorders (obsessive-compulsive disorder, attention-deficit/hyperactivity disorder [ADHD], problematic Internet use, generalized anxiety disorder), and personality questionnaires of impulsivity and compulsivity...
August 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28738096/the-placebo-effect-and-its-clinical-associations-in-gambling-disorder
#13
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Although gambling disorder is prevalent and functionally impairing, no FDA-approved medications exist for its treatment. The ability of clinical trials to detect the benefits of active treatment has been hindered by an unusually high placebo response. Virtually nothing is known about baseline clinical characteristics that might predict placebo response in those with gambling disorder. METHODS: Participants (N = 152) assigned to placebo were pooled from multiple double-blind trials of gambling disorder...
August 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28734718/shoulder-activity-level-and-progression-of-degenerative-cuff-disease
#14
Jay D Keener, Nathan W Skelley, Georgia Stobbs-Cucchi, Karen Steger-May, Aaron M Chamberlain, Alex W Aleem, Robert H Brophy
BACKGROUND: This study prospectively examined the relationship of direct and indirect measures of shoulder activity with the risks of tear progression and pain development in subjects with an asymptomatic degenerative rotator cuff tear. METHODS: A cohort of asymptomatic degenerative rotator cuff tears was prospectively monitored annually, documenting tear size progression with ultrasound imaging and potential shoulder pain development. Shoulder activity level, self-reported occupational and physical demand level, and hand dominance were compared with risks of tear enlargement and future pain development...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28725385/do-movement-behaviors-identify-reproductive-habitat-sampling-for-wild-turkeys
#15
Mason D Conley, Nathan A Yeldell, Michael J Chamberlain, Bret A Collier
Selection of habitats has regularly been suggested to influence species demography at both local and broad scales. The expectation is that selection behaviors have positive benefits via greater fitness or increased survival. The current paradigm of habitat selection theory suggests a hierarchical process, where an individual first selects where they choose to live (e.g., range) and then searches and selects locations within this range meeting life history needs. Using high-frequency GPS data collected from reproductively active Rio Grande (n = 21) and Eastern (n = 23) wild turkeys, we evaluated a long-standing theory for ground-nesting galliformes, in that movements during the prenesting period are behaviorally focused on sampling available habitats to optimize the selection of nesting sites...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28721034/readmission-after-copd-exacerbation-scale-determining-30-day-readmission-risk-for-copd-patients
#16
Christine Sm Lau, Brianna L Siracuse, Ronald S Chamberlain
BACKGROUND: COPD affects over 13 million Americans, and accounts for over half a million hospitalizations annually. The Hospital Readmission Reduction Program, established by the Affordable Care Act requires the Centers for Medicare and Medicaid Services to reduce payments to hospitals with excess readmissions for COPD as of 2015. This study sought to develop a predictive readmission scale to identify COPD patients at higher readmission risk. METHODS: Demographic and clinical data on 339,389 patients from New York and California (derivation cohort) and 258,113 patients from Washington and Florida (validation cohort) were abstracted from the State Inpatient Database (2006-2011), and the Readmission After COPD Exacerbation (RACE) Scale was developed to predict 30-day readmission risk...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28714432/paths-to-improving-care-of-australian-aboriginal-and-torres-strait-islander-women-following-gestational-diabetes
#17
Sandra Campbell, Nicolette Roux, Cilla Preece, Eileen Rafter, Bronwyn Davis, Jackie Mein, Jacqueline Boyle, Bronwyn Fredericks, Catherine Chamberlain
Aim To understand enablers and barriers influencing postpartum screening for type 2 diabetes following gestational diabetes in Australian Indigenous women and how screening might be improved. BACKGROUND: Australian Indigenous women with gestational diabetes mellitus (GDM) are less likely than other Australian women to receive postpartum diabetes screening. This is despite a fourfold higher risk of developing type 2 diabetes within eight years postpartum. METHODS: We conducted interviews with seven Indigenous women with previous GDM, focus groups with 20 Indigenous health workers and workshops with 24 other health professionals...
July 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28709794/performance-of-patient-reported-outcomes-measurement-information-system-promis-upper-extremity-ue-versus-physical-function-pf-computer-adaptive-tests-cats-in-upper-extremity-clinics
#18
Casey M Beleckas, Alex Padovano, Jason Guattery, Aaron M Chamberlain, Jay D Keener, Ryan P Calfee
PURPOSE: To examine the performance of the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) Function Computer Adaptive Test (CAT) relative to the PROMIS Physical Function (PF) CAT in patients seeking specialty care for upper extremity conditions. METHODS: This observational trial analyzed prospectively collected PROMIS UE and PF CAT scores from 5,202 adult patients with 10,344 outpatient clinic visits presenting to a tertiary orthopedic clinic...
July 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28709634/examining-the-role-of-the-pediatric-emergency-department-in-reducing-unintended-adolescent-pregnancy
#19
Michelle Solomon, Gia M Badolato, Lauren S Chernick, Maria E Trent, James M Chamberlain, Monika K Goyal
OBJECTIVES: To determine pregnancy risk and receptiveness to emergency department (ED)-based pregnancy prevention interventions among adolescents accessing care in the ED. STUDY DESIGN: Cross-sectional electronic survey of adolescent females in a pediatric ED used to calculate the Pregnancy Risk Index, a validated measure estimating the annual risk of becoming pregnant based on recent sexual activity, contraceptive method(s), method-specific contraceptive failure rates, and interest in receipt of ED-based contraceptive services...
July 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28700812/disparities-in-location-of-death-of-adolescents-and-young-adults-with-cancer-a-longitudinal-population-study-in-california
#20
Nitya Rajeshuni, Emily E Johnston, Olga Saynina, Lee M Sanders, Lisa J Chamberlain
BACKGROUND: Patients with a terminal illness should have access to their chosen location of death. Cancer is the leading cause of non-accidental death among adolescents and young adults (AYAs; those aged 15-39 years). Although surveys have suggested that a majority of these patients prefer a home death, to the authors' knowledge, little is known regarding their barriers to accessing their preferred location of death. As a first step, the authors sought to determine, across a large population, 20-year trends in the location of death among AYA patients with cancer...
July 12, 2017: Cancer
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