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Brendan M Patterson, Nathan D Orvets, Alexander W Aleem, Jay D Keener, Ryan P Calfee, Devon C Nixon, Aaron M Chamberlain
BACKGROUND: The Patient-Reported Outcomes Measurement Information System (PROMIS) is being used to assess outcomes in many patient populations despite limited validation. The purpose of this study was to investigate the relationship between American Shoulder and Elbow Surgeons (ASES) and Simple Shoulder Test (SST) scores and PROMIS Physical Function (PF) and Upper Extremity (UE) function scores collected preoperatively in patients undergoing rotator cuff repair. METHODS: This cross-sectional study analyzed 164 consecutive patients undergoing arthroscopic rotator cuff repair...
June 2018: Journal of Shoulder and Elbow Surgery
Samuel R Chamberlain, Jon E Grant
BACKGROUND: Disorders of impulsivity are common, functionally impairing, and highly relevant across different clinical and research settings. Few structured clinical interviews for the identification and diagnosis of impulse control disorders exist, and none have been validated in a community sample in terms of psychometric properties. METHODS: The Minnesota Impulse control disorders Interview (MIDI v2.0) was administered to an enriched sample of 293 non-treatment seeking adults aged 18-35 years, recruited using media advertisements in two large US cities...
May 8, 2018: Psychiatry Research
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
Jon E Grant, Samuel R Chamberlain
Trichotillomania is several times more common in women and has peak onset around puberty. The role of sex hormones, however, has received little research. 11 adolescent girls with trichotillomania, post-menarche and not taking birth control, were examined on a variety of clinical measures. Participants provided saliva samples for analysis of estradiol, progesterone, and testosterone levels. Lower progesterone was associated with more severe symptoms and lower levels of all hormones were associated with worse overall functioning...
May 5, 2018: Psychiatry Research
Lenore R Jarvis, Kristen A Breslin, Gia M Badolato, James M Chamberlain, Monika K Goyal
OBJECTIVES: The aim of this study was to determine the (1) proportion of screened postpartum depression (PPD)-positive mothers, (2) associated risk factors, and (3) impact of PPD screening in a pediatric emergency department (PED). STUDY DESIGN: We performed a pilot cohort study using a convenience sample of mothers (n = 209, all ages) of infant patients 6 months or younger presenting to a PED. Mothers completed a computerized survey that included the Edinburgh Postnatal Depression Scale...
May 5, 2018: Pediatric Emergency Care
Jon E Grant, Samuel R Chamberlain
No abstract text is available yet for this article.
May 7, 2018: CNS Spectrums
Kathryn A Chamberlain, Kenneth S Rankin, Adam Briscoe, David Deehan, Philip J Hyde
Poly-ether-ether-ketone (PEEK), having shown favorable biocompatibility in spinal applications is being considered as an alternative biomaterial in orthopaedics, either as part of an all-polymer bearing couple, or a replacement for the metallic component in hard-on-soft bearings. Throughout the literature ultra-high molecular weight polyethylene exhibits a range of wear behavior dependent upon the amount of cross shear (CS) present in the bearing motion; in comparison, the behavior of PEEK bearing combinations subject to cross shear conditions is less understood...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Samuel R Chamberlain, Jon E Grant
OBJECTIVE: Compulsivity refers to a tendency toward repetitive habitual behaviors. Multiple disorders have compulsive symptoms at their core, including substance use disorders, gambling disorder, and obsessive-compulsive disorder. The aim of this study was to validate a scale for the objective, transdiagnostic measurement of compulsivity. METHODS: The 15-item Cambridge-Chicago Compulsivity Trait Scale (CHI-T) was developed for the rapid but comprehensive measurement of compulsivity...
May 7, 2018: CNS Spectrums
Joseph W Hinton, John L Gittleman, Frank T van Manen, Michael J Chamberlain
Anthropogenic hybridization of historically isolated taxa has become a primary conservation challenge for many imperiled species. Indeed, hybridization between red wolves ( Canis rufus ) and coyotes ( Canis latrans ) poses a significant challenge to red wolf recovery. We considered seven hypotheses to assess factors influencing hybridization between red wolves and coyotes via pair-bonding between the two species. Because long-term monogamy and defense of all-purpose territories are core characteristics of both species, mate choice has long-term consequences...
April 2018: Ecology and Evolution
Samuel I Anyanwu, Akins Doherty, Michael D Powell, Chamberlain Obialo, Ming B Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W Newman
Background: Extracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. Our goal was to identify HIV and human proteins (HPs) in urinary EVs from HIV+ patients and compare them to HIV- samples. Methods: Urine samples were collected from HIV+ ( n = 35) and HIV- ( n = 12) individuals. EVs were isolated by ultrafiltration and characterized using transmission electron microscopy, tandem mass spectrometry (LC/MS/MS), and nanoparticle tracking analysis (NTA)...
2018: Advances in Virology
Margaret H Sibley, L Eugene Arnold, James M Swanson, Traci M Kennedy, Brooke S G Molina, Lily T Hechtman, Arunima Roy, John T Mitchell
No abstract text is available yet for this article.
May 1, 2018: American Journal of Psychiatry
Samuel R Chamberlain, Ulrich Müller
No abstract text is available yet for this article.
May 1, 2018: American Journal of Psychiatry
Yuto Suda, John Chamberlain, Stuart Dowall, Masayuki Saijo, Taisuke Horimoto, Roger Hewson, Masayuki Shimojima
Crimean-Congo haemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often called biosafety level 4 (BSL-4) or containment level 4 (CL-4) laboratories when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is time-consuming and awkward resulting in delays. We herein show that the serum neutralising activity against the virus can be measured in low-containment laboratories using a pseudotyped virus...
April 27, 2018: Japanese Journal of Infectious Diseases
Zachary S L Foster, Scott Chamberlain, Niklaus J Grünwald
The taxa R package provides a set of tools for defining and manipulating taxonomic data. The recent and widespread application of DNA sequencing to community composition studies is making large data sets with taxonomic information commonplace. However, compared to typical tabular data, this information is encoded in many different ways and the hierarchical nature of taxonomic classifications makes it difficult to work with. There are many R packages that use taxonomic data to varying degrees but there is currently no cross-package standard for how this information is encoded and manipulated...
2018: F1000Research
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Kleptomania (compulsive stealing) remains poorly understood, with limited data regarding its underlying pathophysiology and appropriate treatment choices. METHODS: Participants (N = 112) age 18 to 65 with a primary, current diagnosis of kleptomania were assessed for the severity of their stealing behavior and urges to steal, as well as related mental health symptoms. To identify clinical and demographic measures associated with variation in disease severity, we utilized the statistical technique of partial least squares...
May 2018: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
Sarah A Sullivan, Robert Carroll, Tim J Peters, Tim Amos, Peter B Jones, Max Marshall, Max Birchwood, David Fowler, Sonia Johnson, Helen L Fisher, Barnaby Major, Nikola Rahaman, John Joyce, Nick Chamberlain-Kent, Jo Lawrence, Paul Moran, Kate Tilling
AIM: Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have alternative explanations. METHODS: Data from 2 cohorts of patients with first episode psychosis were used (n = 2134). Measures of DUP were assessed at baseline and outcomes at 12 months. Regression models were used to investigate the associations between DUP and outcomes...
April 26, 2018: Early Intervention in Psychiatry
Alphonsus H C Ng, Ryan Fobel, Christian Fobel, Julian Lamanna, Darius G Rackus, Aimee Summers, Christopher Dixon, Michael D M Dryden, Charis Lam, Man Ho, Nooman S Mufti, Victor Lee, Mohd Afiq Mohd Asri, Edward A Sykes, M Dean Chamberlain, Rachael Joseph, Maurice Ope, Heather M Scobie, Alaine Knipes, Paul A Rota, Nina Marano, Paul M Chege, Mary Njuguna, Rosemary Nzunza, Ngina Kisangau, John Kiogora, Michael Karuingi, John Wagacha Burton, Peter Borus, Eugene Lam, Aaron R Wheeler
Serosurveys are useful for assessing population susceptibility to vaccine-preventable disease outbreaks. Although at-risk populations in remote areas could benefit from this type of information, they face several logistical barriers to implementation, such as lack of access to centralized laboratories, cold storage, and transport of samples. We describe a potential solution: a compact and portable, field-deployable, point-of-care system relying on digital microfluidics that can rapidly test a small volume of capillary blood for disease-specific antibodies...
April 25, 2018: Science Translational Medicine
Christiane Weirauch, Kyle Whorrall, Alexander Knyshov, Rochelle Hoey-Chamberlain
The Neotropical biodiversity of the cryptic and tiny minute litter bugs in the family Schizopteridae-although thought to be the best documented tropical fauna of Schizopteridae-is still poorly known. Sixteen species of Schizopteridae have been described from Costa Rica, 13 of which during the past few years, and the last new genus of Schizopteridae from that country was described more than half a century ago. We here describe and document a new monotypic genus of Schizopteridae from Costa Rica, Meganannus n...
January 9, 2018: Zootaxa
R Andersen, T H Borch, A Draghi, A Gokuldass, M A H Rana, M Pedersen, M Nielsen, P Kongsted, J W Kjeldsen, M C W Westergaard, H D Radic, C A Chamberlain, L R Hölmich, H W Hendel, M S Larsen, Ö Met, I M Svane, M Donia
Background: The majority of patients with metastatic melanoma obtain only short-term or no benefit at all from checkpoint inhibitor (CPI) immunotherapy. In this study, we investigated whether the immune system of patients progressing following CPI treatment was able to generate functional tumor-specific immune responses. Materials and methods: Tumor-infiltrating lymphocytes (TILs) were isolated and expanded from metastatic melanoma lesions which progressed during or after anti-PD-1 and anti-CTLA-4 treatment...
April 24, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Austin W Blum, Samuel R Chamberlain, Michael D Harries, Brian L Odlaug, Sarah A Redden, Jon E Grant
Excoriation (skin-picking) disorder (SPD) has similarities to obsessive-compulsive disorder (OCD) and is included within the obsessive-compulsive and related disorders (OCRD) diagnostic class in DSM-5. Separate neuroimaging and neurocognitive studies suggest that people affected by SPD find it difficult to inhibit dominant motor responses due to a failure of "top-down" control mechanisms. No study has examined the neural correlates of SPD in participants with varying degrees of impulsive motor behavior...
April 24, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
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