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https://www.readbyqxmd.com/read/28540346/less-invasive-surfactant-administration-reduces-the-need-for-mechanical-ventilation-in-preterm-infants-a-meta-analysis
#1
Christine S M Lau, Ronald S Chamberlain, Shyan Sun
Neonatal respiratory distress syndrome due to surfactant deficiency is associated with high morbidity and mortality in preterm infants, and the use of less invasive surfactant administration (LISA) has been increasingly studied. This meta-analysis found that LISA via thin catheter significantly reduced the need for mechanical ventilation within the first 72 hours (relative risk [RR] = 0.677; P = .021), duration of mechanical ventilation (difference in means [MD] = -39.302 hours; P < .001), duration of supplemental oxygen (MD = -68...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28532939/guiding-flying-spot-laser-transepithelial-phototherapeutic-keratectomy-with-optical-coherence-tomography
#2
REVIEW
Yan Li, Hideaki Yokogawa, Maolong Tang, Winston Chamberlain, Xinbo Zhang, David Huang
PURPOSE: To analyze transepithelial phototherapeutic keratectomy (PTK) results using optical coherence tomography (OCT) and develop a model to guide the laser dioptric and depth settings. SETTING: Casey Eye Institute, Portland, Oregon, USA. DESIGN: Prospective nonrandomized case series. METHODS: Patients with superficial corneal opacities and irregularities had transepithelial PTK with a flying-spot excimer laser by combining wide-zone myopic and hyperopic astigmatic ablations...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28522685/correction-self-reactive-vh4-34-expressing-igg-b-cells-recognize-commensal-bacteria
#3
Jean-Nicolas Schickel, Salomé Glauzy, Yen-Shing Ng, Nicolas Chamberlain, Christopher Massad, Isabelle Isnardi, Nathan Katz, Gulbu Uzel, Steven M Holland, Capucine Picard, Anne Puel, Jean-Laurent Casanova, Eric Meffre
No abstract text is available yet for this article.
May 18, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28521019/a-whole-system-approach-to-improving-mortality-associated-with-acute-kidney-injury
#4
Thangavelu Chandrasekar, Asheesh Sharma, Lucinda Tennent, Christopher Wong, Peter Chamberlain, Kottarathil A Abraham
BACKGROUND: Acute kidney injury (AKI) is in the main managed by non-nephrologists, many who feel challenged by or lack awareness of the complexity that the renal element adds to their patients' care. National reports have raised major concerns about the quality of care and have predicted that mortality reductions of 30% are achievable with good medical practice. AIM: This quality improvement project evaluated whether a whole system approach could improve outcomes for patients with AKI...
May 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28514440/extreme-hydrothermal-conditions-at-an-active-plate-bounding-fault
#5
Rupert Sutherland, John Townend, Virginia Toy, Phaedra Upton, Jamie Coussens, Michael Allen, Laura-May Baratin, Nicolas Barth, Leeza Becroft, Carolin Boese, Austin Boles, Carolyn Boulton, Neil G R Broderick, Lucie Janku-Capova, Brett M Carpenter, Bernard Célérier, Calum Chamberlain, Alan Cooper, Ashley Coutts, Simon Cox, Lisa Craw, Mai-Linh Doan, Jennifer Eccles, Dan Faulkner, Jason Grieve, Julia Grochowski, Anton Gulley, Arthur Hartog, Jamie Howarth, Katrina Jacobs, Tamara Jeppson, Naoki Kato, Steven Keys, Martina Kirilova, Yusuke Kometani, Rob Langridge, Weiren Lin, Timothy Little, Adrienn Lukacs, Deirdre Mallyon, Elisabetta Mariani, Cécile Massiot, Loren Mathewson, Ben Melosh, Catriona Menzies, Jo Moore, Luiz Morales, Chance Morgan, Hiroshi Mori, Andre Niemeijer, Osamu Nishikawa, David Prior, Katrina Sauer, Martha Savage, Anja Schleicher, Douglas R Schmitt, Norio Shigematsu, Sam Taylor-Offord, Damon Teagle, Harold Tobin, Robert Valdez, Konrad Weaver, Thomas Wiersberg, Jack Williams, Nick Woodman, Martin Zimmer
Temperature and fluid pressure conditions control rock deformation and mineralization on geological faults, and hence the distribution of earthquakes. Typical intraplate continental crust has hydrostatic fluid pressure and a near-surface thermal gradient of 31 ± 15 degrees Celsius per kilometre. At temperatures above 300-450 degrees Celsius, usually found at depths greater than 10-15 kilometres, the intra-crystalline plasticity of quartz and feldspar relieves stress by aseismic creep and earthquakes are infrequent...
May 17, 2017: Nature
https://www.readbyqxmd.com/read/28509823/progression-of-fatty-muscle-degeneration-in-atraumatic-rotator-cuff-tears
#6
Jonah Hebert-Davies, Sharlene A Teefey, Karen Steger-May, Aaron M Chamberlain, William Middleton, Kathryn Robinson, Ken Yamaguchi, Jay D Keener
BACKGROUND: The purpose of this prospective study was to examine the progression of fatty muscle degeneration over time in asymptomatic shoulders with degenerative rotator cuff tears. METHODS: Subjects with an asymptomatic rotator cuff tear in 1 shoulder and pain due to rotator cuff disease in the contralateral shoulder were enrolled in a prospective cohort. Subjects were followed annually with shoulder ultrasonography, which evaluated tear size, location, and fatty muscle degeneration...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28501373/evaluating-appropriate-use-of-pediatric-echocardiograms-for-chest-pain-in-outpatient-clinics
#7
Reid C Chamberlain, Jonathan H Pelletier, Sarah Blanchard, Christoph P Hornik, Kevin D Hill, Michael J Campbell
BACKGROUND: Echocardiography is often used in the evaluation of pediatric chest pain, but the incidence of cardiac pathology is low. In 2014, the American College of Cardiology published appropriate use criteria (AUC) for echocardiography including recommendations for pediatric chest pain. We evaluated the frequency and diagnostic yield of echocardiograms performed for each AUC indication and cost associated with echocardiograms performed for indications meeting the "rarely appropriate" criteria...
May 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28500559/nivolumab-for-patients-with-recurrent-glioblastoma-progressing-on-bevacizumab-a-retrospective-case-series
#8
Marc C Chamberlain, Bryan T Kim
A single institution retrospective evaluation of nivolumab following disease progression on bevacizumab in adults with recurrent glioblastoma (GBM) with an objective of determining progression free survival (PFS). There is no accepted therapy for recurrent GBM after failure of bevacizumab. 16 adults, ages 52-72 years (median 62), with recurrent GBM were treated. All patients had previously been treated with surgery, concurrent radiotherapy and temozolomide, and post-radiotherapy temozolomide. Bevacizumab (with or without lomustine) was administered to all patients at first recurrence...
May 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28500047/self-reactive-vh4-34-expressing-igg-b-cells-recognize-commensal-bacteria
#9
Jean-Nicolas Schickel, Salomé Glauzy, Yen-Shing Ng, Nicolas Chamberlain, Christopher Massad, Isabelle Isnardi, Nathan Katz, Gulbu Uzel, Steven M Holland, Capucine Picard, Anne Puel, Jean-Laurent Casanova, Eric Meffre
The germline immunoglobulin (Ig) variable heavy chain 4-34 (VH4-34) gene segment encodes in humans intrinsically self-reactive antibodies that recognize I/i carbohydrates expressed by erythrocytes with a specific motif in their framework region 1 (FWR1). VH4-34-expressing clones are common in the naive B cell repertoire but are rarely found in IgG memory B cells from healthy individuals. In contrast, CD27(+)IgG(+) B cells from patients genetically deficient for IRAK4 or MYD88, which mediate the function of Toll-like receptors (TLRs) except TLR3, contained VH4-34-expressing clones and showed decreased somatic hypermutation frequencies...
May 12, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28496364/oligodendrogliomas-in-pediatric-and-adult-patients-an-outcome-based-study-from-the-surveillance-epidemiology-and-end-result-database
#10
Christine Sm Lau, Krishnaraj Mahendraraj, Ronald S Chamberlain
INTRODUCTION: Oligodendrogliomas (OGs) account for <20% of all intracranial tumors and 25% of gliomas. Despite improvements in imaging techniques allowing for earlier diagnosis, OG is rare among the pediatric population. This study examines a large cohort of OG patients in an effort to define the demographic, clinical, and pathologic factors associated with clinical and survival outcomes. METHODS: Data on 7,001 OG patients were abstracted from the Surveillance, Epidemiology, and End Result (SEER) database (1973-2013)...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28495335/50-years-of-prehospital-resuscitation-reflection-and-celebration
#11
EDITORIAL
Mickey S Eisenberg, Douglas Chamberlain
No abstract text is available yet for this article.
May 8, 2017: Resuscitation
https://www.readbyqxmd.com/read/28494481/enhanced-hip-fracture-management-use-of-statistical-methods-and-dataset-to-evaluate-a-fractured-neck-of-femur-fast-track-pathway-pilot-study
#12
Nigel Gilchrist, Kristian Dalzell, Scott Pearson, Gary Hooper, Kit Hoeben, Jeremy Hickling, John McKie, Ma Yi, Sandra Chamberlain, Caroline McCullough, Marc Gutenstein
The increasing elderly population and subsequent rise in total hip fracture(s) in this group means more effective management strategies are necessary to improve efficiency. We have changed our patient care strategy from the emergency department (ED), acute orthopaedic wards, operating theatre, post-operation and rehabilitation, and called it Fracture Neck of Femur Fast Track Pathway. All clinical data and actions were captured, integrated and displayed on a weekly basis using 'signalfromnoise' (SFN) software...
May 12, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28493324/level-specific-amputations-and-resulting-regenerative-outcomes-in-the-mouse-distal-phalanx
#13
Connie S Chamberlain, Justin J Jeffery, Ellen M Leiferman, Tugrul Yildirim, Xin Sun, Geoffrey S Baer, William L Murphy, Ray Vanderby
No abstract text is available yet for this article.
May 10, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28488262/estimating-the-incidence-of-traumatic-spinal-cord-injuries-in-switzerland-using-administrative-data-to-identify-potential-coverage-error-in-a-cohort-study
#14
Jonviea D Chamberlain, Elias Ronca, Martin Wg Brinkhof
INTRODUCTION: Inferences from population-based cohort studies may be inaccurate as a result of biased coverage of the target population. We investigated the presence of absolute coverage error and selection bias in the Swiss Spinal Cord Injury (SwiSCI) cohort study, using a secondary, nationally representative data source. The proposed methodology is applicable to future Swiss cohort studies aiming to assess their cover-age error. METHODS: ICD-10 codes relating to traumatic spinal cord injuries (TSI) (S14...
May 10, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28476053/transmission-of-donor-derived-breast-carcinoma-as-a-recurrent-mass-in-a-keratolimbal-allograft
#15
Audra K Miller, Jonathan W Young, David J Wilson, Jennifer Dunlap, Winston Chamberlain
PURPOSE: To report a case of local transmission of invasive lobular carcinoma from a donor to a recipient in a keratolimbal allograft after cessation of systemic immunosuppressive therapy. METHODS: This is a case report including the clinicopathologic findings. Sections of the donor breast tumor and recipient conjunctival lesions were stained with hematoxylin and eosin. Immunohistochemical studies were performed using pancytokeratin, CK7, CK20, CAM 5.2, CD138, TTF1, estrogen receptor, progesterone receptor, GATA-3, GCDFP-15, and mammaglobin...
June 2017: Cornea
https://www.readbyqxmd.com/read/28473034/perceived-discrimination-and-cardiovascular-outcomes-in-older-african-americans-insights-from-the-jackson-heart-study
#16
Shannon M Dunlay, Steven J Lippmann, Melissa A Greiner, Emily C O'Brien, Alanna M Chamberlain, Robert J Mentz, Mario Sims
OBJECTIVE: To assess the associations of perceived discrimination and cardiovascular (CV) outcomes in African Americans (AAs) in the Jackson Heart Study. PATIENTS AND METHODS: In 5085 AAs free of clinical CV disease at baseline enrolled in the Jackson Heart Study from September 26, 2000, through March 31, 2004, and followed through 2012, associations of everyday discrimination (frequency of occurrences of perceived unfair treatment) and lifetime discrimination (perceived unfair treatment in 9 life domains) with CV outcomes (all-cause mortality, incident coronary heart disease [CHD], incident stroke, and heart failure [HF] hospitalization) were examined using Cox proportional hazards regression models...
May 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28457924/surgical-intervention-for-unstable-craniovertebral-junction-anomalies-with-a-narrow-c2-pedicle
#17
Rami Darwazeh, Qiang Liu, Lei Deng, Jiajie Xia, Mohammed A Elzain, Mazhar Darwazeh, Piyush Sharma, Bo Zhang, Yi Yan
OBJECTIVE: To investigate and report a novel surgical technique of screws insertion and posterior surgical reduction as well as explore its clinical results. METHODS: From September 2008 to September 2012, 41 cases of unstable craniovertebral junction anomalies with a narrow C2 pedicle were treated at our department. All patients underwent "posterior reduction and internal fixation of the occipital bone with superior or inferior articular process of C2 and lateral mass of C3 on the narrowed C2 pedicle side -for non-narrowed C2 pedicle side, the screw was only inserted into C2 pedicle without extending the fixation to C3 vertebrae- using a titanium screw-rod (plate) fixation system"...
April 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28453751/the-neurologic-assessment-in-neuro-oncology-nano-scale-a-tool-to-assess-neurologic-function-for-integration-into-the-response-assessment-in-neuro-oncology-rano-criteria
#18
Lakshmi Nayak, Lisa M DeAngelis, Alba A Brandes, David M Peereboom, Evanthia Galanis, Nancy U Lin, Riccardo Soffietti, David R Macdonald, Marc Chamberlain, James Perry, Kurt Jaeckle, Minesh Mehta, Roger Stupp, Alona Muzikansky, Elena Pentsova, Timothy Cloughesy, Fabio M Iwamoto, Joerg-Christian Tonn, Michael A Vogelbaum, Patrick Y Wen, Martin J van den Bent, David A Reardon
Background.: The Macdonald criteria and the Response Assessment in Neuro-Oncology (RANO) criteria define radiologic parameters to classify therapeutic outcome among patients with malignant glioma and specify that clinical status must be incorporated and prioritized for overall assessment. But neither provides specific parameters to do so. We hypothesized that a standardized metric to measure neurologic function will permit more effective overall response assessment in neuro-oncology. Methods...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453615/do-patient-access-schemes-for-high-cost-cancer-drugs-deliver-value-to-society-lessons-from-the-nhs-cancer-drugs-fund
#19
A Aggarwal, T Fojo, C Chamberlain, C Davis, R Sullivan
Background: The NHS Cancer Drugs Fund (CDF) was established in 2010 to reduce delays and improve access to cancer drugs, including those that had been previously appraised but not approved by NICE (National Institute for Health and Care Excellence). After 1.3 billion GBP expenditure, a UK parliamentary review in 2016 rationalized the CDF back into NICE. Methods: This paper analyses the potential value delivered by the CDF according to six value criteria. This includes validated clinical benefits scales, cost-effectiveness criteria as defined by NICE and an assessment of real-world data...
April 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28449033/response-assessment-in-medulloblastoma-and-leptomeningeal-seeding-tumors-recommendations-from-the-response-assessment-in-pediatric-neuro-oncology-committee
#20
Katherine E Warren, Gilbert Vezina, Tina Y Poussaint, Monika Warmuth-Metz, Marc C Chamberlain, Roger J Packer, Alba A Brandes, Moshe Reiss, Stewart Goldman, Michael J Fisher, Ian F Pollack, Michael D Prados, Patrick Y Wen, Susan M Chang, Christelle Dufour, David Zurakowski, Rolf D Kortmann, Mark W Kieran
Lack of standard response criteria in clinical trials for medulloblastoma and other seeding tumors complicates assessment of therapeutic efficacy and comparisons across studies. An international working group was established to develop consensus recommendations for response assessment. The aim is that these recommendations be prospectively evaluated in clinical trials, with the goal of achieving more reliable risk stratification and uniformity across clinical trials. Current practices and literature review were performed to identify major confounding issues and justify subsequently developed recommendations; in areas lacking scientific investigations, recommendations were based on experience of committee members and consensus was reached after discussion...
April 25, 2017: Neuro-oncology
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