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https://www.readbyqxmd.com/read/27918351/pediatric-oncology-discharges-with-febrile-neutropenia-variation-in-location-of-care
#1
Elysia Alvarez, Lisa J Chamberlain, Catherine Aftandilian, Olga Saynina, Paul Wise
We examined the use of Pediatric Cancer Specialty Centers (PCSCs) over time and the length of stay (LOS) in pediatric oncology patients with a diagnosis of febrile neutropenia. PCSCs were defined as Children's Oncology Group and California Children's Services designated centers. We performed a retrospective analysis on all discharges of pediatric (0 to 18) oncology patients with febrile neutropenia in California (1983 to 2011) using the private Office of Statewide Health Planning and Development database. We examined influence of age, sex, race/ethnicity, payer, income, distance, tumor type, and complications on utilization of PCSCs and LOS (SAS 9...
December 1, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27906106/loss-of-niche-satellite-cell-interactions-in-syndecan-3-null-mice-alters-muscle-progenitor-cell-homeostasis-improving-muscle-regeneration
#2
Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, Bradley B Olwin
BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts...
October 4, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27901515/neurocognitive-and-clinical-correlates-of-gambling-behavior-based-on-mode-of-gambling
#3
Eric W Leppink, Austin W Blum, Samuel Chamberlain, Jon E Grant
BACKGROUND: Gambling opportunities have expanded greatly in recent years, with ever-increasing availability via the internet as well as land-based options (eg, casinos). Although some research suggests that internet gamblers have higher rates of disordered gambling than land-based only gamblers, the clinical and cognitive importance of these findings is unknown. METHODS: We recruited 542 young adults (age 18 to 29) and compared land- based only (n = 385 [70.8%]) and mixed internet/land-based gamblers (LBGs) (n = 157 [28...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27899165/cognitive-dysfunction-in-body-dysmorphic-disorder-new-implications-for-nosological-systems-and-neurobiological-models
#4
Kiri Jefferies-Sewell, Samuel R Chamberlain, Naomi A Fineberg, Keith R Laws
: Introduction Body dysmorphic disorder (BDD) is a debilitating disorder, characterized by obsessions and compulsions relating specifically to perceived appearance, and which has been newly classified within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Obsessive-Compulsive and Related Disorders grouping. Until now, little research has been conducted into the cognitive profile of this disorder. METHODS: Participants with BDD (n=12) and participants without BDD (n=16) were tested using a computerized neurocognitive battery investigating attentional set-shifting (Intra/Extra Dimensional Set Shift Task), decision-making (Cambridge Gamble Task), motor response-inhibition (Stop-Signal Reaction Time Task), and affective processing (Affective Go-No Go Task)...
November 30, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27894197/temporal-validation-of-a-simplified-blastocyst-grading-system
#5
Alison Richardson, Sophie Brearley, Saran Ahitan, Sarah Chamberlain, Tracey Davey, Lyndsey Zujovic, James Hopkisson, Bruce Campbell, Nick Raine-Fenning
We have recently established the clinical effectiveness and credibility of a simplified blastocyst grading system by demonstrating its prognostic potential and the inter- and intra-observer variability associated with it. To be considered clinically useful, however, the grading system also needs to be accurate (i.e. well calibrated with good discriminative ability). This study prospectively evaluates the performance of the grading system on subsequent patients from the same IVF unit in an attempt to temporally validate the model...
November 28, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27880643/highlights-from-the-literature
#6
David Schiff, Sean Lawler, Marc Chamberlain, Karen Wright, Krishna Bhat
No abstract text is available yet for this article.
December 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27869628/what-s-new-in-shoulder-and-elbow-surgery
#7
REVIEW
Aaron M Chamberlain, Surena Namdari, Jay D Keener
No abstract text is available yet for this article.
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27850852/1216-effects-of-implementing-delirium-screening-in-a-pediatric-intensive-care-unit
#8
Teia Brandenburg, Andrea Chamberlain, Ranjit Chima
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27844311/phase-ii-study-of-medi-575-an-anti-platelet-derived-growth-factor-%C3%AE-antibody-in-patients-with-recurrent-glioblastoma
#9
Surasak Phuphanich, Jeffrey Raizer, Marc Chamberlain, Paola Canelos, Rajesh Narwal, Shengyan Hong, Robert Miday, Minal Nade, Kevin Laubscher
MEDI-575, an immunoglobulin G2κ monoclonal antibody, selectively binds to platelet-derived growth factor-α receptor (PDGFR-α) with high specificity. This multicenter, single-arm, open-label, phase II study evaluated the efficacy and safety of MEDI-575 in patients with recurrent glioblastoma. Adults with first recurrence of glioblastoma following surgery, temozolomide, and radiation received MEDI-575 25 mg/kg intravenously over 60 min every 21 days until disease progression or unacceptable toxicity. Six-month progression-free survival rate (PFS-6) was the primary end point; secondary measures included response rate, overall survival (OS), and safety/tolerability...
November 14, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27826730/sub-clinical-alcohol-consumption-and-gambling-disorder
#10
Michael D Harries, Sarah A Redden, Eric W Leppink, Samuel R Chamberlain, Jon E Grant
While it is well established that gambling disorder is associated with alcohol use disorder, less is known regarding whether sub-clinical alcohol consumption increases gambling behavior. This study examined the effects of varying levels of alcohol consumption on clinical and cognitive measures. The sample consisted of 572 non-treatment seeking gamblers age 18-29 who were divided into three groups: non-current drinkers, current drinkers who did not qualify for an alcohol use disorder, and those with an alcohol use disorder (AUD)...
November 8, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27826610/identification-of-long-bone-fractures-in-radiology-reports-using-natural-language-processing-to-support-healthcare-quality-improvement
#11
Robert W Grundmeier, Aaron J Masino, T Charles Casper, Jonathan M Dean, Jamie Bell, Rene Enriquez, Sara Deakyne, James M Chamberlain, Elizabeth R Alpern
BACKGROUND: Important information to support healthcare quality improvement is often recorded in free text documents such as radiology reports. Natural language processing (NLP) methods may help extract this information, but these methods have rarely been applied outside the research laboratories where they were developed. OBJECTIVE: To implement and validate NLP tools to identify long bone fractures for pediatric emergency medicine quality improvement. METHODS: Using freely available statistical software packages, we implemented NLP methods to identify long bone fractures from radiology reports...
November 9, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27822725/enhanced-recovery-after-surgery-programs-improve-patient-outcomes-and-recovery-a-meta-analysis
#12
Christine S M Lau, Ronald S Chamberlain
INTRODUCTION: Enhanced recovery after surgery (ERAS) programs have been developed to improve patient outcomes, accelerate recovery after surgery, and reduce healthcare costs. ERAS programs are a multimodal approach, with interventions during all stages of care. This meta-analysis examines the impact of ERAS programs on patient outcomes and recovery. METHODS: A comprehensive search of all published randomized control trials (RCTs) assessing the use of ERAS programs in surgical patients was conducted...
November 7, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27822007/trends-in-incidence-survival-and-management-of-uveal-melanoma-a-population-based-study-of-7-516-patients-from-the-surveillance-epidemiology-and-end-results-database-1973-2012
#13
Krishnaraj Mahendraraj, Christine Sm Lau, Injoon Lee, Ronald S Chamberlain
INTRODUCTION: Uveal melanoma (UM) is the most common primary intraocular malignancy, despite comprising <5% of all melanomas. To date, relatively few case series of UM have been published. Moreover, the factors influencing survival remain largely unknown. This study sought to analyze the impact of demographics, histology, clinical presentation, and treatments on the clinical outcomes of UM in a large modern nationwide patient cohort. METHODS: Demographics and clinical data were abstracted on 277,120 histologically confirmed melanoma patients from the Surveillance, Epidemiology, and End Results database between 1973 and 2012...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27801599/is-v%C3%AC-o2-supressed-during-nonapnoeic-facial-submersion
#14
Sarah Anderson, Maggie R Chamberlain, Samantha Musgrove, Antonia Partusch, Keagan R J Tice, David B Thorp
The mammalian dive response (DR) is described as oxygen-conserving based on measures of bradycardia, peripheral vasoconstriction, and decreased ventilation (V̇E). Using a model of simulated diving, this study examined the effect of nonapnoeic facial submersions (NAFS) on oxygen consumption (V̇O2). 19 participants performed four 2-min NAFS with 8 min of rest between each. Two submersions were performed in 5 °C water, 2 in 25 °C water. Heart rate (HR) was collected using chest strap monitors. A tube connected to the inspired port of a non-rebreathing valve allowed participants to breathe during facial submersion...
August 4, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27798073/drugged-drivers-blood-concentrations-in-england-and-wales-prior-to-the-introduction-of-per-se-limits
#15
Brian Rooney, Goncalo Jorge Gouveia, Neville Isles, Lynda Lawrence, Tara Brodie, Zorana Grahovac, Mark Chamberlain, Gavin Trotter
This report details the blood concentration of drugs found in motorists suspected of driving under the influence of drugs from 2010 to 2012 in England and Wales. This study was carried out as new legislation has come into place, setting fixed blood concentration limits for drugs in motorists. These include a cannabis (Δ9-THC) blood concentration of 2 µg/L, amphetamine 250 µg/L, benzoylecgonine (BZE) 50 µg/L, cocaine 10 µg/L, 6-monoacetylmorphine 5 µg/L, morphine 80 µg/L, diazepam 550 µg/L and methadone 500 µg/L...
October 26, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27797811/il4i1-augments-cns-remyelination-and-axonal-protection-by-modulating-t-cell-driven-inflammation
#16
Konstantina Psachoulia, Kelly A Chamberlain, Dongeun Heo, Stephanie E Davis, Jeremiah D Paskus, Sonia E Nanescu, Jeffrey L Dupree, Thomas A Wynn, Jeffrey K Huang
SEE PLUCHINO AND PERUZZOTTI-JAMETTI DOI101093/AWW266 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Myelin regeneration (remyelination) is a spontaneous process that occurs following central nervous system demyelination. However, for reasons that remain poorly understood, remyelination fails in the progressive phase of multiple sclerosis. Emerging evidence indicates that alternatively activated macrophages in central nervous system lesions are required for oligodendrocyte progenitor differentiation into remyelinating oligodendrocytes...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27766464/calorie-intake-and-gambling-is-fat-and-sugar-consumption-impulsive
#17
Samuel R Chamberlain, Sarah A Redden, Jon E Grant
Excessive calorie intake constitutes a global public health concern, due to its associated range of untoward outcomes. Gambling is commonplace and gambling disorder is now considered a behavioral addiction in DSM-5. The relationships between calorie intake, gambling, and other types of putatively addictive and impulsive behaviors have received virtually no research attention. Two-hundred twenty-five young adults who gamble were recruited from two Mid-Western university communities in the United States using media advertisements...
October 20, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27766042/retaining-early-career-registered-nurses-a-case-study
#18
Jane Mills, Jennifer Chamberlain-Salaun, Helena Harrison, Karen Yates, Andrea O'Shea
BACKGROUND: A core objective of the Australian health system is to provide high quality, safe health care that meets the needs of all Australians. To achieve this, an adequate and effective workforce must support the delivery of care. With rapidly changing health care systems and consumer demographics, demand for care is increasing and retention of sufficient numbers of skilled staff is now a critical priority to meet current and future health care demands. Nurses are the largest cohort of professionals within the health workforce...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27765989/coronostoma-claireae-n-sp-nematoda-rhabditida-oxyuridomorpha-coronostomatidae-from-the-indigenous-milliped-narceus-gordanus-chamberlain-1943-diplopoda-spirobolida-in-ocala-national-forest-florida
#19
Gary Phillips, Ernest C Bernard, Robert J Pivar, John K Moulton, Rowland M Shelley
Twenty-four individuals of Narceus gordanus (Diplopoda: Spirobolidae) were collected in Ocala National Forest, FL, between November 2013 and July 2014. Each specimen was dissected to extract the intestine, which was removed and examined for parasitic nematodes. Coronostoma claireae n. sp. was collected from the hindgut and midgut of 10 specimens, and its morphology was examined with brightfield, differential interference contrast, phase contrast, and scanning electron microscopy. This species is separated from other Coronostoma spp...
September 2016: Journal of Nematology
https://www.readbyqxmd.com/read/27761195/impact-of-isometric-contraction-of-anterior-cervical-muscles-on-cervical-lordosis
#20
Curtis A Fedorchuk, Matthew McCoy, Douglas F Lightstone, David A Bak, Jacque Moser, Brett Kubricht, John Packer, Dustin Walton, Jose Binongo
OBJECTIVE: This study investigates the impact of isometric contraction of anterior cervical muscles on cervical lordosis. METHODS: 29 volunteers were randomly assigned to an anterior head translation (n=15) or anterior head flexion (n=14) group. Resting neutral lateral cervical x-rays were compared to x-rays of sustained isometric contraction of the anterior cervical muscles producing anterior head translation or anterior head flexion. RESULTS: Paired sample t-tests indicate no significant difference between pre and post anterior head translation or anterior head flexion...
September 2016: Journal of Radiology Case Reports
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